Soniya Pinto is currently working at
the St. Jude Children’s Research Hospital, Diagnostic Imaging Department,
Comprehensive Cancer Center. Her research is interested in the imaging of
neurologic complications of CAR-T cells; investigating the use of the Apparent
Diffusion Coefficient as a predictive marker for neurotoxicity in CAR-T cell
patients; and applications of proton MR spectroscopy in non-oncologic CNS
diseases. She was awarded the 2022 CHLA core pilot research award.
Giedre Krenciute is a faculty member in the Department of Bone Marrow
Transplantation and Cellular Therapy at St Jude
Children’s Research
Hospital. She received her Ph.D. in Biochemistry and Molecular Biology at
Baylor College of Medicine (BCM), followed by post-doctoral training in the
Center for Cell and Gene Therapy at BCM. The major focus of her laboratory is
to develop an effective immunotherapy for pediatric brain tumors using
genetically modified T cells. Research areas include generating and optimizing
CAR T-cells to
target brain tumor-associated antigens, enhancing CAR T-cell effector functions
by
different next-generation genetic manipulations, and understanding tumor
escape mechanisms to design superior immunotherapy-based treatments.