Protein MMP12

URN urn:agi-llid:4321
Total Entities 0
Connectivity 3590
Name MMP12
Description matrix metallopeptidase 12 (macrophage elastase)
Notes This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Primary Cell Localization Extracellular

Pathway Proteins Involved in Atherosclerosis
Proteins Involved in Arterial Hypertension
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Proteins Involved in Ulcerative Colitis
Proteins Involved in Rheumatoid Arthritis
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Pulmonary Emphysema
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
BMP7/BMPR2/ACVR2 Expression Targets
CSF2 -> STAT Expression Targets
Integrins in Cancer Cell Motility, Invasion and Survival
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IL13 Expression Targets
CSF1 -> STAT Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
TLR4 -> AP-1 Expression Targets
IL1B Expression Targets
WNT7A Expression Targets
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of body weight gain
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of neutrophil count
Neighbors of mortality rate
Neighbors of lesion area
Neighbors of tumor grade
Neighbors of vascular leakage
Neighbors of vascular density
Neighbors of functional status
Neighbors of infarct area
Neighbors of carotid intima-media thickness
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of body weight gain
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of neutrophil count
Neighbors of mortality rate
Neighbors of lesion area
Neighbors of tumor grade
Neighbors of vascular leakage
Neighbors of vascular density
Neighbors of functional status
Neighbors of infarct area
Neighbors of carotid intima-media thickness
Neighbors of cell development
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of SMC proliferation
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of phagocytosis
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of hemopoiesis
Neighbors of lung development
Neighbors of transcription activation
Neighbors of senescence
Neighbors of hepatocyte proliferation
Neighbors of neuroprotection
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cell differentiation
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of asthma
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of airway inflammation
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of macrophage infiltration
Neighbors of neuroinflammation
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of melanoma
Neighbors of cartilage degeneration
Neighbors of neoplasm invasion
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of neoplasm
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of hypertension
Neighbors of epithelial cell
Neighbors of vascular smooth muscle cell
Neighbors of monocyte
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of mononuclear cell
Neighbors of dendritic cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of activated T-cell
Neighbors of granulocyte
Neighbors of myeloid cell
Neighbors of cytotrophoblast
Neighbors of tumor infiltrating macrophage
Neighbors of B-cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of adipose macrophage
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of lung
Neighbors of skin
Neighbors of airway
Neighbors of blood vessel
Neighbors of aorta
Neighbors of esophagus
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of coronary artery
Neighbors of vitreous body
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of transforming growth factor
Neighbors of cytokine
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NAD(P)H oxidase
Neighbors of SMAD subfamily
Neighbors of inflammatory cytokine
Neighbors of PDGF-BB
Neighbors of GPCR
Neighbors of proteasome endopeptidase complex
Neighbors of STAT5
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of ITG
Neighbors of pancreatic elastase
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 4321

LocusLink ID 4321
17381
117033

Alias matrix metallopeptidase 12
matrix metallopeptidase 12 (macrophage elastase)
Macrophage metalloelastase
human macrophage metalloelastase
matrix metalloprotease 12 (macrophage elastase)
metalloelastase
matrix metalloprotease 12
macrophage elastase
MGC138506
MMP-12
matrix metalloproteinase 12 (macrophage elastase)
AV378681
Matrix metalloproteinase XII
Matrix metalloprotease XII
Mmel
matrix metallopeptidase XII
human macrophage metalloelastases
metalloelastases
OTTMUSP00000034110
matrix metalloproteinase 12
ME
HME
MME
matrix metalloproteinase-12
macrophage-metalloelastase
Mmp12

EC Number 3.4.24.65

GO ID 0005509
0005518
0001047
0004175
0004222
0043565
0008270
0098586
0030574
0060309
0022617
0030198
1904905
0000122
0060339
0060054
1902741
0045944
0060340
0006606
0006508
0050691
1904645
0035313
0005737
0031012
0005576
0005615
0005634
0016787
0046872
0008237
0008233
0010628
1901163
0042060
0050679
0042493
0001666
0014070
0004252
0005578
0008152
0042221

KEGG ID hsa:4321
mmu:17381
rno:117033

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 9 2.46 cM
9 1.0 cM

OMIM ID 601046

Rat chromosome position 8q11

Hugo ID 7158
HGNC:7158

Human chromosome position 11q22.2
11q22.3

Swiss-Prot Accession P39900
P39900.1
P34960
Q3TCW6
P34960.3
Q63341
R9PXT7
Q63341.1
B2R9X8
B7ZLF6
Q2M1L9
Q3TB28
Q3TBV6
Q3TBV9
Q3TD61
Q3U1S8
Q3U1S9
Q3U2R8
Q3UBC5
Q4FJM7
Q8BJ92
Q8BJB3
Q8BJB6
Q8BJB8
Q8BJB9
Q8VED6
Q5I0P0
Q13165
Q99745
Q6GX99
Q8BJC0

PIR ID A49499
A42401

GenBank ID NC_000011
NM_002426
NP_002417
NG_032936
AP000789
AY856072
AAW29944
CH471065
EAW67033
FP885831
U25346
AAB06314
U78045
AAB36943
AI343504
AI352562
AK313959
BAG36675
AW172994
BC112301
AAI12302
BC143773
AAI43774
BE440047
BE813419
BG206655
L23808
AAA58658
P39900
NC_000075
NM_001320077
NP_001307006
XM_017313160
XP_017168649
NM_001320076
NP_001307005
NM_008605
NP_032631
AC169512
CH466522
EDL24933
AK089295
BAC40832
AK089309
BAC40836
AK089335
BAC40846
AK089452
BAC40889
AK089509
BAC40909
AK089523
BAC40913
AK090051
BAC41067
AK150596
BAE29689
AK151021
BAE30039
AK151273
BAE30260
AK151933
BAE30809
AK155139
BAE33072
AK155743
BAE33411
AK155747
BAE33414
AK155748
BAE33415
AK155841
AK155865
BAE33469
AK170360
BAE41743
AK170364
BAE41746
AK170500
BAE41839
AK170667
AK170798
BAE42035
AK170804
BAE42039
AK170976
BAE42154
AK171006
BAE42177
AK171032
BAE42198
AK171036
BAE42201
AK171176
BAE42294
AK171428
BAE42446
AK171435
AK171447
BAE42457
AK171448
BAE42458
AK171449
BAE42459
AK171450
BAE42460
AK171466
BAE42472
AK171468
BAE42474
AK171470
BAE42476
AK171472
BAE42478
AK171485
BAE42486
AK171518
BAE42502
AK171542
BAE42516
AK171570
BAE42531
AY622972
AAT46403
BC019135
AAH19135
BY195619
BY539785
CT010377
CAJ18584
M82831
AAA39526
P34960
NC_005107
XM_017595420
XP_017450909
NM_053963
NP_446415
AC_000076
AAHX01053075
AC120947
CH473993
EDL78537
BC088120
AAH88120
CB791502
X98517
CAA67142
Q63341
NC_018922
AMYH02025489
HQ258263
ADR83017
XM_011242358
XP_011240660
XM_011242357
XP_011240659
AC_000031
AAHY01075863
AC_000143
ABBA01039930
XM_006509847
XP_006509910
NW_003871077
NT_033899
NW_001838042
NW_925173
AC_000054
CR594246
CR603756
Q13165
Q99745
NT_039471
NW_001030907
Q3TCW6
Q6GX99
Q8BJC0
NW_001084867
NW_047798

Swiss-Prot ID MMP12_HUMAN
MMP12_MOUSE
MMP12_RAT
B2R9X8_HUMAN

Cell Localization Secreted
Extracellular space
Extracellular matrix
Secreted, extracellular space, extracellular matrix
Extracellular

Ensembl ID ENSG00000262406
ENSP00000458585.1
ENST00000571244.2
ENSMUSG00000049723
ENSMUSP00000114129.1
ENSMUST00000120655.7
ENSMUSP00000005950.5
ENSMUST00000005950.11
ENSRNOG00000030187
ENSRNOP00000011727.6
ENSRNOT00000011727.6
ENSP00000458585
ENST00000571244
ENSMUSP00000005950
ENSMUST00000005950
ENSMUSP00000114129
ENSMUST00000120655
ENSRNOP00000011727
ENSRNOT00000011727

MGI ID MGI:97005
97005

RGD ID 620195

Unigene ID Hs.1695
Hs.709832
Mm.2055
Rn.33193

Homologene ID 20547

IPI ID IPI00298246
IPI00475653
IPI00321648
IPI00881760
IPI00881624
IPI00403307
IPI00882065
IPI00199747