URN | urn:agi-llid:7249 |
---|---|
Total Entities | 0 |
Connectivity | 2180 |
Name | TSC2 |
Description | tuberous sclerosis 2 |
Notes | Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
ObjectType | Protein |
Pathway | Oncogene Induced Cellular Senescence |
---|---|
DNA Persistent Repair Inhibits mTOR Signaling | |
mTOR Signaling Activation by Fatty Acids and Glucose | |
mTOR Signaling Activation by Amino Acids | |
mTOR Signaling | |
mTOR Signaling Hyperfunction | |
Hypoxia Inhibits mTOR Signaling | |
SIRT1 Signaling in Aging | |
Insulin Influence on Protein Synthesis | |
Insulin Signaling | |
Preconditioning Ischemia | |
Proteins Involved in Diabetes Mellitus Type 2 | |
Glucocorticoids in Insulin Resistance in Skeletal Muscles | |
Proteins Involved in non-Alcoholic Fatty Liver Disease | |
Peutz-Jeghers Syndrome | |
Proteins Involved in Peutz-Jeghers Syndrome | |
Proteins Involved in Pancreatic Cancer | |
Proteins Involved in Epilepsy | |
Ketogenic Diet Mechanism (Hypothesis) | |
Blood-Brain Barrier Disruption in Epileptiform Disorders | |
mTOR Hyperactivation after Status Epilepticus | |
Angiogenesis in Endometriosis | |
Androgen Receptor/SGK1 Signaling | |
Polycystins Mutation Effects in Cystic Kidney Disease | |
Proteins Involved in Polycystic Kidney Disease | |
AREG -> HIF1A Expression Targets | |
EGF -> HIF1A Expression Targets | |
EGFR/ERBB2 -> HIF1A Signaling | |
EREG -> HIF1A Expression Target | |
HBEGF -> HIF1A Expression Targets | |
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression | |
TGFB Signaling activation by Blocking of Tumor Suppressors | |
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors | |
HIF1A as Master Regulator of Angiogenesis in Cancer | |
MTOR/TORC in Cancer Cell Motility and Invasion | |
TGFB Family in Epithelial to Mesenchymal Transition in Cancer | |
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells | |
Genes with Mutations in Cancer Metabolic Reprogramming | |
Proteins with Altered Expression in Cancer Metabolic Reprogramming | |
NRG1 -> HIF1A Expression Target | |
Androgen Receptor non-Genomic Signaling | |
TGF-beta Signaling | |
AMPK Signaling | |
mTOR Signaling | |
VEGF Signaling | |
EGFR Signaling | |
TGFA -> HIF1A Expression Targets | |
Model of PPARG signaling in psoriasis | |
PPARG negative regulators and targets | |
Model of PPARG related pathways in psoriasis (short version) | |
1_Formation of cysts in polycystic kidney disease | |
3_Enhanced angiogenesis in endometriosis | |
2_Neuron and Schwann cell death | |
Model of PPARG signaling in psoriais (tested) |
Group | Genes with Mutations Associated with Pancreatic Cancer |
---|---|
Proteins Involved in Cowden Syndrome | |
Genes Associated with Syndromic Epilepsy | |
Genes Associated with Mental Retardation and Brain Malformations in Epilepsy |
MedScan ID | 7249 |
---|
LocusLink ID | 7249 |
---|---|
22084 | |
24855 |
Alias | tuberin isoform III |
---|---|
Tuberins | |
tuberin isoform II | |
tuberous sclerosis complex 2 protein | |
tuberous sclerosis-II | |
PPP1R160 | |
FLJ43106 | |
OTTHUMP00000198394 | |
tuberous sclerosis 2 | |
Tuberous sclerosis 2, (renal carcinoma) | |
tumor suppressor protein tuberous sclerosis complex 2 | |
TSC complex subunit 2 | |
tuberin isoform I | |
tuberin isoform 2 | |
TCS2 | |
TSC4 | |
tuberin isoform 3 | |
LOC124054 | |
Tuberin | |
tuberous sclerosis-2 | |
tuberin isoform 1 | |
protein phosphatase 1, regulatory subunit 160 | |
tuberous sclerosis 2 homolog protein | |
tuberous sclerosis II | |
TSC2 | |
LAM | |
tuberous sclerosis 2 protein | |
Nafld | |
tuberous sclerosis 2 protein homolog | |
Rc | |
renal carcinoma |
GO ID | 0005096 |
---|---|
0051879 | |
0019902 | |
0042803 | |
0031267 | |
0043276 | |
0006897 | |
0007507 | |
0048009 | |
0032007 | |
0030178 | |
0008285 | |
0046627 | |
1901525 | |
0014067 | |
0051898 | |
0006469 | |
0001843 | |
0050918 | |
0043547 | |
0016239 | |
0006606 | |
0043491 | |
0008104 | |
0051726 | |
0030100 | |
0046626 | |
0051056 | |
0016192 | |
0016032 | |
0005794 | |
0033596 | |
0005737 | |
0005829 | |
0005764 | |
0016020 | |
0005634 | |
0048471 | |
0014069 | |
0071889 | |
0047485 | |
0046982 | |
0007568 | |
0030030 | |
0032869 | |
0030010 | |
0045184 | |
0046323 | |
0043407 | |
1904262 | |
0050771 | |
0045792 | |
0050680 | |
0010719 | |
0048147 | |
0016242 | |
0048550 | |
0001933 | |
1905563 | |
0014065 | |
0010508 | |
0045785 | |
0060999 | |
0010763 | |
0010976 | |
0045944 | |
0051291 | |
0051260 | |
0034394 | |
0044861 | |
0099175 | |
0001666 | |
0007165 | |
0035176 | |
0005901 | |
0042995 | |
0005856 | |
0030425 | |
0098978 | |
0030426 | |
0043231 | |
0045121 | |
0043005 | |
0043025 | |
0032991 | |
0045202 | |
0007050 | |
0071500 | |
0043234 | |
0038095 | |
0006953 | |
0007173 | |
0008543 | |
0045087 | |
0008286 | |
0048011 | |
0048015 | |
0032320 | |
0005623 | |
0005622 | |
0005097 | |
0032851 |
KEGG ID | hsa:7249 |
---|---|
rno:24855 | |
mmu:22084 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 17 12.41 cM |
---|
OMIM ID | 191092 |
---|---|
607341 | |
606690 | |
613254 |
Rat chromosome position | 10q12 |
---|
Hugo ID | 12363 |
---|---|
HGNC:12363 |
Human chromosome position | 16p13.3 |
---|
Swiss-Prot Accession | P49815 |
---|---|
X5D7Q2 | |
B3KWH7 | |
Q5HYF7 | |
H3BMQ0 | |
P49815.2 | |
Q3UGI8 | |
Q7TT21 | |
Q3UHB2 | |
Q3UG88 | |
Q3TQ10 | |
Q61037.1 | |
P49816 | |
A0A0G2JSL4 | |
P49816.1 | |
A7E2E2 | |
B4DIL8 | |
B4DIQ7 | |
B4DRN2 | |
B7Z2B8 | |
C9J378 | |
O75275 | |
Q4LE71 | |
Q8TAZ1 | |
X5D2U8 | |
Q61037 |
PIR ID | A49420 |
---|---|
S57329 |
Swiss-Prot ID | TSC2_HUMAN |
---|---|
TSC2_RAT |
Cell Localization | Cytoplasm |
---|---|
Membrane | |
Nucleus |
Ensembl ID | ENSG00000103197 |
---|---|
ENSP00000219476.3 | |
ENST00000219476.9 | |
ENSP00000384468.2 | |
ENST00000401874.7 | |
ENSP00000344383.4 | |
ENST00000350773.9 | |
ENSP00000399232.2 | |
ENST00000439673.6 | |
ENSP00000371978.6 | |
ENST00000382538.10 | |
ENSP00000454487.1 | |
ENST00000568454.6 | |
ENSP00000495459.1 | |
ENST00000642365.1 | |
ENSP00000496611.1 | |
ENST00000644329.1 | |
ENSMUSG00000002496 | |
ENSMUSP00000094986.1 | |
ENSMUST00000097373.1 | |
ENSMUSP00000154338.1 | |
ENSMUST00000227745.1 | |
ENSMUSP00000153792.1 | |
ENSMUST00000226398.1 | |
ENSMUSP00000154706.1 | |
ENSMUST00000228412.1 | |
ENSMUSP00000153869.1 | |
ENSMUST00000226284.1 | |
ENSMUSP00000153758.1 | |
ENSMUST00000227607.1 | |
ENSRNOG00000011375 | |
ENSRNOP00000016221.1 | |
ENSRNOT00000016221.3 | |
ENSRNOP00000039381.5 | |
ENSRNOT00000052138.6 | |
ENSP00000219476 | |
ENST00000219476 | |
ENSP00000384468 | |
ENST00000401874 | |
ENSP00000344383 | |
ENST00000350773 | |
ENSP00000399232 | |
ENST00000439673 | |
ENSP00000371978 | |
ENST00000382538 | |
ENSMUSP00000094986 | |
ENSMUST00000097373 | |
ENSRNOP00000016221 | |
ENSRNOT00000016221 |
MGI ID | MGI:102548 |
---|---|
102548 |
RGD ID | 3908 |
---|
Unigene ID | Hs.90303 |
---|---|
Mm.30435 | |
Rn.5875 |
Homologene ID | 462 |
---|