Protein TYK2

URN urn:agi-llid:7297
Total Entities 0
Connectivity 4875
Name TYK2
Description tyrosine kinase 2
Notes This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Thrombopoietin Receptors Signaling in Platelet Maturation
CD8+ T-Cell Activation
Th1-Cell Differentiation
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
Plasmin Effects in Inflammation
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
Mast-Cell Activation without Degranulation
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
IL6 Expression Targets -> Nociception
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Toll-like Receptors in beta-Cell
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Genes with Susceptibility for Crohn's Disease and Ulcerative Colitis
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
Periostin (POSTN) Production by Airway Epithelium in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
B-Cells Function in Systemic Scleroderma
Th17-Cell Numbers Reduction in HIV
Diabetes Induced Periodontitis
Genes with Mutations Associated with Psoriatic Arthritis
Glioma Invasion Signaling
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Proteins Involved in Endometriosis
IL6/JAK/STAT3 Signaling in Cholesteatoma
Cholesteatoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Cytokines Trigger Otitis Media
Mucin Hyperproduction in Goblet and Mucous Cells
CLCF1 Expression Targets
CTF1 Expression Targets
CSF3 Expression Targets
LIF Expression Targets
CNTF Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> STAT1/NF-kB Expression Targets
GH2/GHR Expression Target
GH1/GHR -> STAT Expression Targets
CSH1/GHR Expression Targets
Receptors and Adaptor Proteins Activated in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
IL12 Antitumor Effect is Blocked in Cancer
IL13/STAT6/ZEB1 Signalling Promotes Cancer Metastatic Progression
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
IDO1 in Cancer Immune Escape
IFNLR1-> STAT/NFKB Signaling
IFNW1/IFNR Expression Target
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
IL22R -> STAT3 Signaling
IL10R -> STAT Signaling
IL13R -> STAT Signaling
IL6R -> STAT Signaling
IL12R -> STAT Signaling
IL12R -> NF-kB/NFATC Signaling
IL13 Expression Targets
IL12B Expression Targets
IL6 Expression Targets
IL10 Expression Targets
IL22 Expression Targets
UrokinaseR -> ELK/SRF Signaling
UrokinaseR -> STAT Signaling
OSM/IL6ST/LIFR Expression Targets
CSF2 -> STAT Signaling
PRL/GHR -> STAT Expression Targets
CSF1 -> STAT Expression Targets
PAF Expression Targets
Thrombopoietin -> STAT Expression Targets
PLAU -> STAT1 Expression Targets
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> STAT Expression Targets
VEGFR -> STAT Signaling
PPAR Psoriasis
Model of PPARG signaling in psoriasis
New Pathway (3)
dsRNA induces innate immunity and INFs in alveolar cells
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
1_Differentiation of psoriatic T cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_The role of endothelial cells in pyelonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Defective tolerance of autoreactive T-cell in T1D
Differentiation of psoriatic T cells
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Inflammatory Bowel Diseases
Genes with Mutations Associated with Psoriatic Arthritis
Genes with Mutations Associated with Endometriosis

Source curated
GO component

MedScan ID 7297
650588
298706

LocusLink ID 7297
54721
100361294
298706
512484

Alias Non-receptor tyrosine-protein kinase TYK2
protein-tyrosine kinase tyk2
JTK1
JTK I
TYK2 kinase
tyrosine kinase II
LOC115716
protein kinase TYK2
LOC100361294
tyrosine kinase 2
TYK2_HUMAN
TYK2
IMD35
tyrosine kinase TYK2
protein-tyrosine kinase tyk2

EC Number 2.7.10.2
2.7.10.1
2.7.1.112

GO ID 0005524
0005131
0004715
0004713
0031702
0019221
0035722
0038155
0070106
0035556
0018108
0006468
0060337
0005737
0005856
0005829
0070062
0016020
0005634
0016301
0000166
0004672
0016740
0016310
0045087
0051427
0031234
0016477
0016772
0038083
0007243
0007169
0005102
0030154
0060338
0042127
0004718
0005515
0007242
0004674

KEGG ID hsa:7297
mmu:54721
rno:100361294

MedLine Reference 10409622
10502458
10531356
10542297
10673353
10899310
10933219
10995743
11399767
11430697
12477932
12554654
12719789
12960323
1386289
14500680
15489334
15883164
15944400
16239216
16551269
17011030
17384181
17548050
2156206
2216457
2247464
7526154
7579387
7589562
7629131
8125298
8432525
8550573
8702790
8780698
9108397
9196040
9305869
9342324
9373149
9374471
9388212
9519782
9633884
9733772
9822675
10349636
11042159
11070173
11070174
11076861
11217851
11313413
11313414
11437454
11877284
12391177
12466851
12517976
12594853
12679810
14500783
14617019
14662340
14768057
15226272
15254900
15488705
15491990
15578097
15782199
16141072
16141073
16148148
16601124
16751369
16982690
17048270
17078929
17372006
17395783

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus
Bos taurus

Mouse chromosome position 9
9 A3

OMIM ID 176941
611521

Rat chromosome position 8q13
8

Hugo ID 12440
HGNC:12440

Human chromosome position 19p13.2

Swiss-Prot Accession A0A024R7E4
P29597
P29597.3
E9QJS1
Q9R117
Q9R117.3
D3ZD03
Q6QB10
Q96CH0
O88431
Q3TXE3
Q52KQ2
Q8VE41
Q9R117.2
Q53HA9
Q2M4G5
Q3TDN4
Q3TIS9
Q3U447
TYK2_HUMAN
INGR1_HUMAN

PIR ID S12127

GenBank ID NC_000019
XR_002958353
XR_001753750
XR_001753751
XR_001753752
XM_011528245
XP_011526547
XM_011528246
XP_011526548
XM_011528247
XP_011526549
XM_011528251
XP_011526553
XM_011528249
XP_011526551
NM_003331
NP_003322
NG_007872
AC011557
AY549314
AAS37680
CH471106
EAW84099
EAW84100
KT584692
AK222672
BAD96392
AK303627
BAG64635
AK308360
AK308379
BC014243
AAH14243
CR995139
DA864169
X54637
CAA38449
P29597
NC_000075
NM_018793
NP_061263
NM_001205312
NP_001192241
XR_001778942
XM_006510492
XP_006510555
XM_011242579
XP_011240881
XM_006510493
XP_006510556
XM_006510494
XP_006510557
AC163637
AF052607
AAC34580
AY902350
AAY21060
CH466522
EDL25159
EDL25160
AF173032
AAD49423
AK134154
AK154438
BAE32587
AK155923
AK159303
BAE34973
AK165483
AK167726
BAE39767
AK170107
BAE41567
AK170940
AK171609
AK195177
AK195939
AK199641
AK199646
AK206451
AK206664
AK217061
BC019789
AAH19789
BC053021
BC094240
AAH94240
Q9R117
NC_005107
XR_593758
XR_593759
XM_006242586
XP_006242648
XM_006242585
XP_006242647
NM_001257347
NP_001244276
XR_001839127
AC_000076
AABR07069438
AAHX01053581
XP_005260106
ABM83618
XM_005260049
XR_356112
XR_356114
XR_356113
AAHY01076444
XM_006242588
XM_006242587
XM_006510495
AABR06053665
AC_000151
AC_000031
NC_018930
ABBA01029934
ABBA01029932
ABBA01029933
XP_011526554
XP_006510558
XP_011526550
AMYH02035492
XP_006242649
XP_011526552
AMYH02035491
ABM86881
XM_011528248
DQ892692
XM_011528252
XM_011528250
DQ895955
XP_006242650
NT_011295
NW_001838483
NW_927195
AC_000062
Q53HA9
NT_039472
NW_001030907
Q2M4G5
Q3TDN4
Q3TIS9
Q3TXE3
Q3U447
Q52KQ2
119604505
119604506
123984545
123998559
15559784
37504
42716354
56405328
62896903
74726316
123779493
123789998
123790567
123790886
123793140
148693212
148693213
18044031
23328874
33860233
5733095
62740256
62910180
74181753
74192938
74198577
74206622
81882293
AI452085
NW_000351
NT_086897
XP_233741
XM_233741
NW_047798
NC_007305
NW_001495323
XM_590006
XP_590006
XM_002729874
XP_002729920
NW_001084867
XM_002726995
XP_002727041
AABR03062309
AABR03062407
AABR03065697
AABR03066411
AAHX01053580

Swiss-Prot ID TYK2_HUMAN
TYK2_MOUSE
Q52KQ2_MOUSE
Q3TXE3_MOUSE
D3ZD03_RAT

Cell Localization Cytoplasm

Ensembl ID ENSG00000105397
ENSP00000431885.1
ENST00000525621.5
ENSP00000264818.6
ENST00000264818.10
ENSP00000433203.1
ENST00000524462.5
ENSMUSG00000032175
ENSMUSP00000150354.1
ENSMUST00000216874.1
ENSMUSP00000150214.1
ENSMUST00000214454.1
ENSMUST00000213717.1
ENSRNOG00000032948
ENSRNOP00000048018.3
ENSRNOT00000041678.5
ENSMUSP00000001036
ENSRNOT00000041678
ENST00000525621
ENST00000524462
ENSP00000264818
ENSRNOP00000048018
ENST00000264818
ENSMUST00000001036
ENSP00000431885
ENSP00000433203

MGI ID MGI:1929470
1929470

RGD ID 2320469
1307164

Unigene ID Mm.450004
Hs.75516
Rn.38688
Mm.20249
Rn.140313
Bt.23803
Rn.202161

Homologene ID 20712

Shape Sickle-vertex

IPI ID IPI00022353
IPI00653270
IPI00359820

Microarray ID 97573_at

Homo sapiens Chromosome position 19p13.2

Ensembl Transcript ID ENST00000264818
ENST00000525621

FunctionalClass ATP binding
Janus kinase
non-membrane spanning protein tyrosine kinase
nucleotide binding
transferase
kinase
protein kinase
protein-tyrosine kinase
protein serine/threonine kinase

Bos taurus Chromosome position 7

Mus musculus Chromosome position 9 A3

KEGG pathway Adipocytokine signaling pathway
Jak-STAT signaling pathway

Rattus norvegicus Chromosome position 8q13

Ensembl Gene ID ENSG00000105397