URN | urn:agi-llid:10532 |
---|---|
Total Entities | 0 |
Connectivity | 1168 |
Name | TICAM1 |
Description | toll-like receptor adaptor molecule 1 |
Notes | This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012] |
Primary Cell Localization | Cytoplasm |
ObjectType | Protein |
Pathway | Cortisol in Resolving Inflammation |
---|---|
NOD-like Receptors | |
Antiviral Signaling through Pattern Recognition Receptors | |
TLR4 Signaling in Leukocytes | |
T-Cell Independent B-Cell Activation | |
Toll-like Receptors in Sterile Inflammation | |
Necrosis | |
MC1R in anti-Inflammatory Signaling | |
Macrophage M1 Lineage | |
CD16/CD14 Proinflammatory Monocyte Activation | |
AXL Receptor Inhibits Macrophages and Dendritic Cells Function | |
Dendritic Cells Function in Atherosclerosis | |
Proteins Involved in Dilated Cardiomyopathy | |
Myocardial Infarction | |
MAVS in Antiviral Innate Immune Response in Myocarditis | |
Proteins Involved in Myocarditis | |
Toll-like Receptors (TLR) in Antiviral Innate Immune Response | |
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus | |
Dendritic Cell Activation in Systemic Lupus Erythematosis | |
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1 | |
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model) | |
Toll-like Receptors in beta-Cell | |
Celiac Disease | |
Crohn's Disease | |
Dendritic Cell Dysfunction in Crohn's disease | |
Dendritic Cell Function in Ulcerative Colitis | |
Nicotine anti-Inflammatory Effect in Ulcerative Colitis | |
Proteins Involved in Antiphospholipid Syndrome | |
TSLP Signaling in Bronchial Epithelial Cell in Asthma | |
Club-Cell Role in Asthma | |
Antigen-Presenting Cell Role in Asthma | |
Mucin Production in Goblet Airway Epithelial Cells | |
Airway Epithelial Cell Dysfunction | |
Monocytes Function in Gout | |
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis | |
Toll-like Receptors (TLR) in Periodontitis | |
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA) | |
PAPA Syndrome | |
TNF Receptor Associated Periodic Syndrome | |
Mevalonate Kinase Deficiency | |
Blau Syndrome | |
Cryopyrin (NLPR3) Associated Periodic Syndromes | |
Familial Cold Autoinflammatory Syndrome 2 | |
Familial Mediterranean Fever | |
Majeed Syndrome | |
Gluten Impact on Neuronal System (Hypothesis) | |
HMGB1 and IL1B in Neuroinflammation | |
Cholesteatoma | |
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes | |
TLR3 Role in Retinal Pigment Epithelial Cell | |
Proteins Involved in Otitis Media | |
Alveolar Macrophages Dysfunction in COPD | |
Mucin Hyperproduction in Goblet and Mucous Cells | |
NFKB Canonical Signaling Activation in Cancer | |
NF-kB Canonical Signaling | |
TLR3 Expression Targets | |
TLR4 -> NF-kB/IRF Expression Targets | |
TLR4 -> IRF Signaling | |
TLR3 -> IRF Signaling | |
TLR3 -> NF-kB Signaling | |
pathway 4 | |
Model of PPARG signaling in psoriasis | |
Model of PPARG related pathways in psoriasis (short version) | |
dsRNA induces innate immunity and INFs in alveolar cells | |
Dendritic Cell Activation in COVID19 | |
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media | |
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD | |
1_Th2 cell response in asthma | |
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease | |
2_Intestine epithelial cells drive immunological responses in ulcerative colitis | |
1_Intestine epithelial cell dysfunction in ulcerative colitis | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
2_Neuron and Schwann cell death | |
Model of PPARG signaling in psoriais (tested) |
MedScan ID | 10532 |
---|
LocusLink ID | 10532 |
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148022 | |
106759 | |
363328 |
Alias | TICAM I |
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OTTMUSP00000017974 | |
TIR domain-containing adaptor protein inducing IFN-beta | |
toll interleukin 1 receptor domain containing adaptor inducing interferon beta | |
LOC148021 | |
LOC224899 | |
AW547018 | |
PRVTIRB | |
IIAE6 | |
TICAM1 | |
PRVTIRBs | |
CL24751 | |
proline-rich, vinculin and TIR domain-containing protein B | |
AW046014 | |
toll-like receptor adaptor molecule 1 | |
LOC193797 | |
TRIF | |
toll/interleukin-1 receptor domain-containing adaptor protein 1 | |
LOC363328 | |
TIR domain-containing adaptor molecule 1 | |
MGC35334 | |
TIR domain containing adaptor inducing interferon-beta | |
MyD88-3 | |
TICAM-1 | |
TIR domain-containing adapter protein inducing IFN-beta | |
putative NF-kappa-B-activating protein 502H | |
toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta | |
TIR domain-containing adapter molecule 1 | |
TIR domain-containing adaptor inducing interferon-beta | |
toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta | |
TIR domain containing adapter inducing interferon-beta | |
toll-like receptor adapter molecule 1 | |
toll/interleukin-1 receptor domain-containing adapter protein 1 |
GO ID | 0019901 |
---|---|
0007249 | |
0002756 | |
0035666 | |
0097190 | |
0071222 | |
0140052 | |
0051607 | |
0006954 | |
0045087 | |
0031663 | |
0002281 | |
0070266 | |
0034128 | |
0030890 | |
0043123 | |
0051092 | |
0010508 | |
0045080 | |
1900017 | |
0010628 | |
0045359 | |
0032755 | |
0002735 | |
0032816 | |
0045429 | |
0032092 | |
0031398 | |
0032760 | |
0043496 | |
0043330 | |
0034138 | |
0016032 | |
0005776 | |
0005829 | |
0010008 | |
0005739 | |
0097342 | |
0006915 | |
0002376 | |
0050871 | |
0032481 | |
0032496 | |
0005737 | |
0031410 | |
0034142 | |
0007165 | |
0008624 | |
0005515 | |
0008063 | |
0004871 | |
0002224 | |
0002755 | |
0034130 | |
0034134 | |
0005886 | |
0009615 |
KEGG ID | hsa:148022 |
---|---|
mmu:106759 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 17 |
---|
OMIM ID | 607601 |
---|---|
614850 |
Rat chromosome position | 9q12 |
---|---|
9 |
Hugo ID | 18348 |
---|---|
HGNC:18348 |
Human chromosome position | 19p13.3 |
---|
Swiss-Prot Accession | Q8IUC6 |
---|---|
Q8IUC6.1 | |
Q80UF7 | |
Q80UF7.1 | |
B3Y691 | |
O75532 | |
Q86XP8 | |
Q96GA0 | |
Q3UDB7 | |
Q3UP66 | |
Q6P6J2 | |
Q8CIB7 | |
Q8JZV0 |
Swiss-Prot ID | TCAM1_HUMAN |
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TCAM1_MOUSE | |
B3Y691_HUMAN |
Cell Localization | Cytoplasmic vesicle |
---|---|
Autophagosome | |
Cytoplasm | |
Cytosol | |
Mitochondrion | |
Cytoplasmic vesicle, autophagosome |
Ensembl ID | ENSG00000127666 |
---|---|
ENSP00000248244.4 | |
ENST00000248244.5 | |
ENSMUSG00000047123 | |
ENSMUSP00000055104.8 | |
ENSMUST00000058136.8 | |
ENST00000248244 | |
ENSP00000248244 | |
ENSMUSP00000055104 | |
ENSMUST00000058136 |
MGI ID | MGI:2147032 |
---|---|
2147032 |
RGD ID | 1590868 |
---|
Unigene ID | Hs.29344 |
---|---|
Mm.203952 |
Homologene ID | 8605 |
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IPI ID | IPI00170381 |
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IPI00216715 | |
IPI00398285 |