Protein S100A8

URN urn:agi-llid:6279
Total Entities 0
Connectivity 2034
Name S100A8
Description S100 calcium binding protein A8
Notes The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
ObjectType Protein

Pathway AHR in Intestinal Cell Antimicrobial Barrier Maintenance
Proteins Involved in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Proteins Involved in Myocarditis
Proteins Involved in Atopic Dermatitis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Dendritic Cells Function in Psoriasis
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Proteins Involved in Cystic Fibrosis
Dendritic Cell Dysfunction in Psoriatic Arthritis
Proteins Involved in Amyotrophic Lateral Sclerosis
Immune System Role in Otitis Media
Proteins Involved in Bronchiectasis
Proteins Involved in Chronic Obstructive Pulmonary Disease
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IFNG/IFNR Expression Targets
IL10 Expression Targets
IL22 Expression Targets
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Bone Marrow
IL1A Expression Targets
VEGFA -> STAT Expression Targets
pprarg neg, uknown targets, ps-positive
dsRNA induces innate immunity and INFs in alveolar cells
AGER feed forward loop in innate immunity
2_Interleukin-17 and interleukin-22 signaling in psoriasis
3_Arterial wall inflammation and calcification in atherosclerosis
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 6279

LocusLink ID 6279
20201
116547

Alias 60B8AG
Leukocyte L1 complex light chain
Cystic fibrosis antigen
B8Ag
Migration inhibitory factor-related protein 8
MRP8
CGLA
urinary stone protein band A
chemotactic cytokine CP-10
OTTHUMP00000015329
L1Ag
S108_HUMAN
CP X
pro-inflammatory S100 cytokine
S100 calcium binding protein A8
Migration inhibitory factor-related protein VIII
OTTHUMP00000015330
chemotactic s100 protein
S100a8
CP-10
AI323541
CAGA protein
S100 calcium binding protein A8 (calgranulin A)
calprotectin L1L subunit
CAGA mRNA
CP10
calgranulin A
CFAG
MA387
P8
MIF
NIF
CAGA
protein S100-A8
MRP-8
S100 calcium-binding protein A8
calgranulin-A
S108
S100 calcium-binding protein A8 (calgranulin A)

GO ID 0050786
0035662
0050544
0005509
0008017
0008270
0006919
0002526
0019730
0006915
0014002
0035425
0006914
0032602
0002544
0001816
0042742
0050832
0006954
0045087
0002523
0070488
0030593
0043312
0018119
0051092
0030307
0050729
2001244
0002793
0051493
0045471
0032496
0010043
0032119
0002224
0042060
0062023
0005856
0005829
0070062
0005576
0005615
0045111
0005634
0005886
0034774
0016209
0046872
0006935
0002376
0050727
0005737
0016020
0098869
0006917
0005515

KEGG ID hsa:6279
mmu:20201
rno:116547

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 3 39.9 cM
3 43.6 cM

OMIM ID 123885

Rat chromosome position 2q34

Hugo ID 10498
HGNC:10498

Human chromosome position 1q21.3
1q21

Swiss-Prot Accession P05109
P05109.1
P27005
Q53X15
P27005.3
P50115
P50115.3
A8K5L3
D3DV37
Q5SY70
Q9UC84
Q9UC92
Q9UCJ0
Q9UCM6
P31724

PIR ID A31848
I56163
JN0685

GenBank ID NC_000001
NM_001319198
NP_001306127
NM_001319197
NP_001306126
NM_001319196
NP_001306125
NM_002964
NP_002955
NM_001319201
NP_001306130
A12027
CAA01001
AL591704
CH471121
EAW53330
EAW53331
M21005
AAA36327
AA401538
AA903259
AI126134
AK291328
BAF84017
BC005928
AAH05928
BP209293
BP226540
BT007378
AAP36042
BU935536
CR407674
CAG28602
X06234
CAA29580
Y00278
CAA68390
P05109
NC_000069
NM_013650
NP_038678
AC122425
CH466547
EDL15111
L76381
AAL40132
X87966
CAA61204
AK157837
BAE34219
AV007095
BC078629
AAH78629
M83218
AAB07229
S57123
AAB25840
Y09039
P27005
NC_005101
XM_006232565
XP_006232627
NM_053822
NP_446274
AC_000070
AAHX01018654
AC097705
CH473976
EDM00536
L18891
AAA41637
P50115
AAHY01029034
ABM87366
CAI19497
XP_011508163
ABBA01049433
XM_005245432
ABM84421
AABR06018860
AC_000133
NC_018912
XP_005245489
AC_000025
AMYH02001902
XM_011509861
DQ893495
DQ896367

Swiss-Prot ID S10A8_HUMAN
S10A8_MOUSE
S10A8_RAT

Cell Localization Secreted
Cytoplasm
Cytoskeleton
Cell membrane
Cytoplasm, cytoskeleton

Ensembl ID ENSG00000143546
ENSP00000357721.1
ENST00000368732.5
ENSP00000357722.3
ENST00000368733.4
ENSMUSG00000056054
ENSMUSP00000064385.8
ENSMUST00000069927.9
ENSRNOG00000011557
ENSRNOP00000015473.1
ENSRNOT00000015473.3
ENSRNOT00000015473
ENSMUST00000069927
ENSP00000357722
ENST00000368733.3
ENSMUSP00000064385
ENSRNOP00000015473
ENST00000368733

MGI ID MGI:88244
88244

RGD ID 620265

Unigene ID Mm.21567
Hs.416073
Rn.31839

Homologene ID 2225

IPI ID IPI00230768
IPI00007047
IPI00231370