Protein IL27RA

URN urn:agi-llid:9466
Total Entities 0
Connectivity 291
Name IL27RA
Description interleukin 27 receptor, alpha
Notes In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Class Receptor

Pathway Th1-Cell Differentiation
AHR Signaling in Tr1 Cells Function
Eosinophil Survival by Cytokine Signaling
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
IL27R -> STAT Signaling
PPAR Psoriasis
1_Differentiation of psoriatic T cells
Differentiation of psoriatic T cells

MedScan ID 9466

LocusLink ID 9466
50931
288905

Alias T-cell cytokine receptor
type I T-cell cytokine receptor
IL27RA
WSX I
IL-27 receptor subunit alpha
cytokine receptor WSX-1
interleukin IL27RA
TCCR
IL-27R subunit alpha
cytokine receptor-like 1
WSX1
UNQ296/PRO336
LOC234540
interleukin-27 receptor subunit alpha
WSX1/IL-27R
cytokine receptor family, class 1 (WSXWS), member 1
wsxws
IL-27R-alpha
IL-27R/WSX1
zcytor1
T-cell cytokine receptor type 1
interleukin 27 receptor, alpha
CRL1
IL27R
IL-27RA
class I cytokine receptor
WSX-1
IL-27R
T cell cytokine receptor
T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
interleukin IL27R
CRL I
Il27ra_predicted

GO ID 0019955
0004896
0045509
0004888
0007166
0050830
0006955
0070106
0070757
2000408
2000317
1905077
1900165
1904468
0002829
0002827
0032729
0048302
0009897
0005887
0005886
0043235
0002692
0016021
0016020
0004872
0007165

KEGG ID hsa:9466
mmu:50931
rno:288905

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 8

OMIM ID 605350

Rat chromosome position 19q11

Hugo ID 17290
HGNC:17290

Human chromosome position 19p13.12
19p13.11

Swiss-Prot Accession Q6UWB1
Q6UWB1.2
O70394
Q3UZN3
O70394.2
D4A6K5
A0A0G2JW79
A0N0L1
O60624
E9QNY4

PIR ID JW0047

GenBank ID NC_000019
NM_004843
NP_004834
NW_021160022
AC022098
CH471106
EAW84389
EAW84390
EF064719
ABK41902
FB507086
CAV32862
HH829741
CBX32720
AF053004
AAC39755
AF106912
AAG26090
AF265242
AAG27297
AI983115
AW298502
AY358876
AAQ89235
BC028003
AAH28003
Q6UWB1
NC_000074
NM_016671
NP_057880
XM_011248437
XP_011246739
XR_001778452
XM_011248438
XP_011246740
AC156028
CH466525
EDL10927
EDL10928
AF053005
AAC40121
AF265243
AAG27298
AK040457
AK133753
BAE21823
BC032878
AAH32878
BF019826
O70394
NC_005118
XM_006255227
XP_006255289
XM_017601191
XP_017456680
XM_006255228
XP_006255290
NM_001105943
NP_001099413
AC_000087
AABR07043168
AABR07043169
AAHX01097744
CH473972
EDL92242
NC_018930
AMYH02035597
AMYH02035598
DQ891051
ABM81977
DQ894230
ABM85156
AC_000030
AAHY01072702
AAHY01072703
AC_000151
ABBA01029695
ABBA01029696
ABBA01029697
XR_387757
XM_006531181
XP_006531244
XM_006531180
XP_006531243
NT_011295
NW_001838483
NW_927195
AC_000062
NT_078575
NW_001030904
Q3UZN3
NW_047534
NW_001084744

Swiss-Prot ID I27RA_HUMAN
I27RA_MOUSE
D4A6K5_RAT
E9QNY4_MOUSE
Q3UZN3_MOUSE
A0N0L1_HUMAN

Cell Localization Membrane

Ensembl ID ENSG00000104998
ENSP00000263379.1
ENST00000263379.4
ENSMUSG00000005465
ENSMUSP00000005601.7
ENSMUST00000005601.8
ENSRNOG00000005747
ENSRNOP00000007726.5
ENSRNOT00000007726.5
ENSRNOP00000069777.1
ENSRNOT00000085630.1
ENST00000263379.3
ENSP00000263379
ENST00000263379
ENSMUSP00000005601
ENSMUST00000005601
ENSRNOP00000007726
ENSRNOT00000007726
ENSRNOP00000069777
ENSRNOT00000085630

MGI ID MGI:1355318
1355318

RGD ID 1305029

Unigene ID Mm.38386
Hs.352155
Rn.47680
Hs.132781

Homologene ID 3562

Shape Stick-vertex

IPI ID IPI00006774
IPI00117451
IPI00371645
IPI00988016