Protein FOXO1

URN urn:agi-llid:2308
Total Entities 0
Connectivity 4482
Name FOXO1
Description forkhead box O1
Notes This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Androgen Deficiency in Male Obesity
SIRT2 Signaling in Aging
SIRT7 Signaling in Aging
SIRT1 Signaling in Aging
MTOR/TP53 Regulates Cell Metabolism
Insulin Influence on Protein Synthesis
Insulin Signaling
Androgens in Adipocyte Activation
LH and FSH Signaling and Steroidogenesis
V(D)J Recombination Activation
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
SCF/SKP2 Complex
Proteins Involved in Hypertrophic Cardiomyopathy
Proteins Involved in Acne Vulgaris
Hyperseborrhea in Acne Vulgaris
Androgen Induced Sebocyte Hyperfunction
Androgens in Sebocyte Maturation
Proteins Involved in Diabetes Mellitus Type 2
Donohue Syndrome Progression (Hypothesis)
Proteins Involved in Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
PNPLA3 in non-Alcoholic Fatty Liver Disease
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Myocyte Dysfunction in Hypoparathyroidism
Adipocyte Hypertrophy and Hyperplasia
Adipokines Production by Adipocyte Impaired in Obesity
Peutz-Jeghers Syndrome
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Ovulation Block
SHBG and IGFBP1 Synthesis Decline in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
TNF Receptor Associated Periodic Syndrome
Cowden Syndrome
ER Stress in Huntington Disease
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Proteins Involved in Medulloblastoma
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins with Altered Expression in Endometriosis
Progesterone Resistance in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
Proteins Involved in Primary Ovarian Insufficiency
LH and FSH Signaling Impairment in Primary Ovarian Insufficiency
Androgen Receptor/Akt Signaling
Alveolar Epithelial Cell Autophagy in COPD
FSHR Expression Targets
PI3K/AKT/MTOR Signaling Activation in Cancer
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
Skeletal Muscle Wasting in Cancer Cachexia
IGF1 -> CEBPA/FOXO1A Expression Targets
IGF2 -> CEBPA/FOXO1A Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
ICAM2 -> CTNNB/FOXO/STAT3 Signaling
InsulinR -> CTNNB/FOXA/FOXO Signaling
IGF1R -> CEBPA/FOXO1A Signaling
IL7R -> FOXO/NF-kB Signaling
IL7 Expression Targets
Leptin -> STAT Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
AngiopoietinR -> FOXO Signaling
NTRK -> FOXO/MYCN Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
AMPK Signaling
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of graft survival
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of long-term survival
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of glucose tolerance
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of muscle mass
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of blood glucose
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of left ventricular ejection fraction
Neighbors of proliferation index
Neighbors of fertility
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of graft survival
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of long-term survival
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of glucose tolerance
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of muscle mass
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of blood glucose
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of left ventricular ejection fraction
Neighbors of proliferation index
Neighbors of fertility
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of heart function
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of reperfusion injury
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of myocardial fibrosis
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of proteinuria
Neighbors of monocyte
Neighbors of macrophage
Neighbors of hepatocyte
Neighbors of endothelial cell
Neighbors of peritoneal macrophage
Neighbors of stem cell
Neighbors of insulin-secreting cell
Neighbors of T-cell
Neighbors of liver
Neighbors of skin
Neighbors of intestine
Neighbors of blood vessel
Neighbors of heart
Neighbors of microvessel
Neighbors of uterus
Neighbors of esophagus
Neighbors of central nervous system
Neighbors of lymphatic system
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of PI3K
Neighbors of STAT family
Neighbors of PDGF
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of AMPK
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of HIF-1
Neighbors of IL12
Neighbors of TSH
Neighbors of proteasome endopeptidase complex
Neighbors of non-coding RNA
Neighbors of STAT5
Neighbors of gonadotropins
Neighbors of FSH
Neighbors of histone
Neighbors of histone acetyltransferase
Neighbors of deacetylase
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
H2A-K119 and H3-K27
New Pathway
3_Increased proliferation of sebocytes in acne vulgaris
2_Progesterone resistance stimulates endometriotic cell survival
2_Impaired steroidogenesis in PCOS
2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD
1_1_Insulin synthesis and secretion: insulin processing and storage
3_3_Beta-cell proliferation and compensation: recovery
4_1_Insulin resistance: insulin signaling
4_3_Insulin resistance: FFA-related insulin resistance

Group Genes with Mutations Associated with Ageing (non-Mammalian Animal Model)
Proteins Involved in Cowden Syndrome

MedScan ID 2308

LocusLink ID 2308
56458
84482

Alias forkhead homologue in rhabdomyosarcoma
FOXO1A
forkhead homolog in rhabdomyosarcoma
forkhead box O1A
forkhead homolog I
Forkhead in rhabdomyosarcoma
transcription factor FKHR
FKH I
transcription factor FOXO 1A
forkhead protein FKHR
forkhead transcription factor FKHR
AI876417
forkhead, Drosophila, homolog of, in rhabdomyosarcoma
transcription factor FOXO 1
FKHR
Fkhr1
forkhead (Drosophila) homolog 1 (rhabdomyosarcoma)
homolog of Drosophila forkhead
forkhead homolog 1 (rhabdomyosarcoma)
OTTHUMP00000018301
forkhead protein I
Forkhead related transcription factor
Foxo I
forkhead box O1
forkhead protein 1
forkhead box O1A (rhabdomyosarcoma)
OTTMUSP00000023486
FKH1
forkhead homolog 1
Fkhr I
Foxo1
FOX O1A
forkhead box protein O1A
forkhead box protein O1
Afxh

GO ID 0003700
0000981
0001227
0008013
0003682
0051721
0043565
0001223
0008134
0031625
0006915
0006914
0001568
0001678
0006974
0070417
0071549
0070301
0071455
0032869
0071732
0034599
0009267
0019221
0070166
0031018
0097009
0045444
0042593
0008286
0043066
0090090
1903243
0045599
0032873
0000122
0045892
0097150
0043065
0010508
0045722
0045732
0045944
0045893
0006473
0035947
2000177
2000377
1902617
0001659
0005737
0005829
0005739
0005654
0005634
0003677
0030154
0042127
0006357
0006355
0010629
0018105
0018107
1903661
0032868
0005667
0045087
0006916
0006351
0048513
0005515
0019901
0000989
0007173
0009790
0003690
0038095
0006366
0008543
0051090
0008301
0001078
0048011
0003705
2001141
0048015
0007389
0009888
1903506
2000505
0044429
0010843
0003704
0016566
0016563
0010553
0006350
0045941
0005575

KEGG ID hsa:2308
mmu:56458
rno:84482

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 3 23.19 cM
3 22.5 cM

OMIM ID 136533
268220

Rat chromosome position 2q26

Hugo ID 3819
HGNC:3819

Human chromosome position 13q14.11
13q14.1

Swiss-Prot Accession Q12778
Q12778.2
Q9R1E0
Q9R1E0.2
G3V7R4
G3V7R4.1
O43523
Q5VYC7
Q6NSK6
Q9JJW4
Q8BPP2
Q8BRS7
Q8CA93
Q9WVH5
Q9ES26

PIR ID S40521

GenBank ID NC_000013
NM_002015
NP_002006
XM_011535008
XP_011533310
XM_011535010
XP_011533312
NG_023244
AL133318
AL355132
AL592167
CH471075
EAX08627
AF032885
AAC39591
AK310511
BC021981
AAH21981
BC070065
AAH70065
BT007455
AAP36123
BX648278
U02310
AAA03629
U36922
Q12778
NC_000069
NM_019739
NP_062713
AC104932
AC163092
CH466530
EDL35224
AF114258
AAD42106
AF126056
AAD40636
AJ252157
CAB86873
AK029013
AK030304
AK039265
BAC30298
AK043583
BAC31588
AK053633
BAC35455
AK054289
AK137629
BAE23437
AK154041
BAE32333
AK185432
AK192846
AK211466
AK211487
AK212278
AK212379
Q9R1E0
NC_005101
NM_001191846
NP_001178775
AC_000070
AABR07010584
AABR07010585
AAHX01016972
AAHX01016973
AAHX01016974
CH474003
EDM14970
AF247812
AAG09779
G3V7R4
CAI16970
ABBA01021295
ABBA01021296
AABR06016643
AABR06016644
ABBA01021294
AABR06016645
U37335
XR_941536
U37334
AC_000025
XM_011535009
AAI52909
AAHY01026720
AAHY01026724
AAHY01026723
AC_000145
AAHY01026722
AAHY01026721
NC_018924
CAH70978
AAHY01026719
AMYH02027907
XP_011533311
BC152908
NT_024524
NW_925473
NW_001838073
AC_000056
NT_039240
NW_001030719
Q8BPP2
Q8BRS7
Q8CA93
Q9JJW4
Q9WVH5
XM_342244
XP_342245
NW_047625
NW_001084804
XM_001056726
XP_001056726
Q9ES26

Swiss-Prot ID FOXO1_HUMAN
FOXO1_MOUSE
FOXO1_RAT
Q9JJW4_MOUSE

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000150907
ENSP00000368880.4
ENST00000379561.6
ENSMUSG00000044167
ENSMUSP00000055308.5
ENSMUST00000053764.6
ENSRNOG00000013397
ENSRNOP00000018244.3
ENSRNOT00000018244.5
ENST00000379561
ENSRNOP00000018244
ENSMUSP00000055308
ENSRNOT00000018244
ENSP00000368880
ENST00000379561.5
ENSMUST00000053764

MGI ID MGI:1890077
1890077

RGD ID 620283

Unigene ID Mm.29891
Rn.116108
Hs.370666

Homologene ID 1527

Shape O-vertex

IPI ID IPI00289866
IPI00314283
IPI00311101
IPI00194593