Functional Class PI3K

URN urn:agi-aopfc:0000447
Total Entities 4
Connectivity 12167
Name PI3K
Description phosphatidylinositol 3-kinase
Notes This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
ObjectType Functional Class

ChildConcepts class II PI3K
class III PI3K complex
class IA PI3K complex
class IB PI3K complex

Pathway Osteoarthritis
Androgen Deficiency in Male Obesity
Oncogene Induced Cellular Senescence
MTHFR Activity Regulation
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Leptin and CCK8 Activate Nodose Ganglia Neuron
Insulin Influence on Protein Synthesis
Insulin Influence on Glycogenesis
Insulin Influence on Lipogenesis
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Insulin Signaling
Prolactin Production
Thrombopoietin Receptors Signaling in Platelet Maturation
Androgens in Adipocyte Activation
LH and FSH Signaling and Steroidogenesis
Toll-like Receptors Act through MYD88-TIRAP Signaling
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Inhibitory Receptor Signaling
Natural Killer Cell Activation through ITSM-Containing Receptors
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
Peripheral T-Cell Tolerance
T-Cell Positive Selection and Neglect Induced Death
T-Cell Central Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
TAM Receptors in Platelet Aggregation
Platelet Activation via Adhesion Molecules
Scavenger Receptors in Platelet Aggregation
Proplatelet Maturation
Bradykinin Effects in Inflammation
Platelet Activation via GPCR Signaling
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Annexins in Inflammation Resolution
Eat me Signal: Apoptotic Cell Induces Phagocytosis
Eicosanoids in Myeloid Cell Activation
Histamine Receptor H3 Signaling in Neurons
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
VEGFA/NOTCH1/WNT Cross-talk in Blood Vessel Sprouting and Branching in Cancer
Vascular Endothelial Cell Activation by NO
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
Lipogenesis Regulation in Adipocyte
Synaptic Potentiation by PKMZ in LTP Maintenance - Active State
Potassium Flux Regulation
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
Sodium Flux Regulation
Vascular Motility
Ca2+ Flux Regulation
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
BDKRB1/2 -> Vasodilation
BDKRB1/2 -> Interleukins Production
CNR1/2 -> Membrane Transport
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD2 -> TRPC1 Transcription
DRD2/4 -> Membrane Transport
GALR1/2/3 -> POMC/NPY Production
CHRM1 -> IL2 Production
CHRM1/2/3/5 -> Ion Channels
PTGER2/3 -> Vascular Motility
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
TACR1 -> TNF/IL6/IL8 Production
Leptin -> NO Production/Vasodilation
CHRNA7 -> NOS1 Production
NTRK1/2/3 -> Acetylcholine Production
EPHB -> NMDA Receptor Activation
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
G0/G1 Phase Transition
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
BMP2 and WNT Signaling in Pulmonary Artery Smooth Muscle Cells
Lymphocyte Mediated Myocardial Injury in Myocarditis
Myocarditis, Acute Viral Overiew
Vascular Reactivity in Raynaud Disease
NO Synthesis in Early Vasospasm
Neurons Necrosis Caused by Energy Deficiency
Contraction Due Vasospasm
Hyperseborrhea in Acne Vulgaris
Androgen Induced Sebocyte Hyperfunction
Androgens in Sebocyte Maturation
Atopic Dermatitis Onset
Acute Phase in Atopic Dermatitis
Atopic Dermatitis
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
Dedifferentiation and Metastatic Progression in Melanoma
MITF as a Regulator of Melanoma Cell Development
Proteins Involved in Melanoma
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Oxidative Stress in Vitiligo
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
Natural Killer Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Glucocorticoids in Insulin Resistance in Skeletal Muscles
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
AGE Related Insulin Resistance in Skeletal Muscles
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Leptin in Insulin Synthesis and Secretion
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Mass Regulation
beta-Cell Function Inhibition by Ciclosporine and Tacrolimus (Rodent Model)
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
RET1 Mutation in Hyperparathyroidism
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Graves Ophthalmopathy
Immune System Activation in Hyperthyroidism
Myocyte Dysfunction in Hypoparathyroidism
Hypoparathyroidism, Primary
Hypothyroidism, Secondary (Central)
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Thymic Follicular Hyperplasia
SOCS3 and PTPN1 in Hypothalamic Neuron Insensitivity to Insulin and Leptin
Fatty Acids in Hypertension and Atherosclerosis Development
Adipocyte Hypertrophy and Hyperplasia
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
CD4+T-Cell Response in Celiac Disease
Enterocyte Mediated Mucosal Damage in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Cetuximab Resistance in Colorectal Cancer
Metastatic Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Proteins Involved in Acute Myeloid Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
Antiphospholipid Antibodies in Platelets and Coagulation Cascade
B-Cell Acute Lymphoblastic Leukemia
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Lymphoma, GCB Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in Multiple Myeloma
Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
T-Cell Acute Lymphoblastic Leukemia
Il17 Signaling Related Neutrophilia in Asthma
Eosinophil Activation and Degranulation in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Exocytosis in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
B-Cell Mediated IgE Production in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Ovulation Block
SHBG and IGFBP1 Synthesis Decline in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
WHIM Syndrome
CD4+ T-Cell Function Decline in HIV
Macrophage Survival through CCR5 and CXCR4 Mediated Signaling
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Mevalonate Kinase Deficiency
Blau Syndrome
Familial Cold Autoinflammatory Syndrome 2
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
BDNF Upregulation Triggered by Seizures
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Astrocytoma
Glioma Invasion Signaling
Proteins Involved in Glioma
Glioma Stem Cell Program Activation
Ependymoma
Medulloblastoma
Vascular Endothelial Cell Vasodilation in Brain
Dopamine Action in CSD Progression
Postsynaptic Neuron Activation
nNOS (NOS1) and iNOS (NOS2) Activation via Glutamate
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
Sonic Hedgehog Signaling in Neuroblastoma
Glutamate Role in Parkinson's Disease
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
MIR155 Role in Th17-Cell in Multiple Sclerosis
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
Brain Cell Necrosis in Vascular Dementia
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
LH and FSH Signaling Impairment in Primary Ovarian Insufficiency
FOXO3 and PTEN Inactivation in Premature Ovarian Failure (Mouse Model)
MIF Role in Cholesteatoma
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
Prostate Cancer
Androgen Receptor/SGK1 Signaling
EPHA2 Mutations in Cataract
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
Glucocorticoid Resistance
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Penile Detumescense Augmentation Mechanisms
Penile Erection Impairment
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Ammonia Effects on Brain Cells
CD157/ITGB2 Signaling in Myeloid Cell
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
AREG -> FOXO3A Expression Target
Noradrenaline/Gs Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
B-Cell Receptor -> NFATC Signaling
B-Cell Receptor -> AP-1 Signaling
B-Cell Receptor -> NF-kB Signaling
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
AGTR1 -> ARRB1/ARRB2 Signaling
Hedgehog Family -> ARRB1/ARRB2 Canonical Signaling
ARRB1/ARRB2 non-CanonicalSignaling and HedgehogFamily
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD22 -> NF-kB Expression Targets
CD19/CR2 Expression Targets
CD8 -> AP-1 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD72 -> NF-kB Expression Targets
CD72 -> STAT Expression Target
CD80 -> STAT Expression Targets
CD81 Expression Targets
CD80 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD86 -> NFATC Expression Targets
CD86 -> STAT Expression Targets
CD86-> NFATC Expression Targets
CD86 -> NF-kB Expression Targets
CHRNA7 -> CREB Signaling
Inositol Phosphate Metabolism
Tamoxifen Induced Endometrial Cancer
Dexamethasone Induced Diabetes
Doxorubicin Induced Cardiotoxicity
Ritonavir Induced Diabetes
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> FOXO3A Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> FOXO3A Expression Target
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> FOXO3A Expression Targets
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> FOXO3A Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> FOXO3A Expression Target
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF10 -> FOXO3A Expression Target
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FPR1 -> Cytoskeleton Signaling
FSHR Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> FOXO3A Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> FOXO3A Signaling
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
Hedgehog Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
Hedgehog Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
Hippo/YAP1 Signaling Deregulation in Cancer
Hypoxia-Induced Cell Death Evasion in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
Inhibition of THBS1 Activates Angiogenesis in Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
HIF1A as Master Regulator of Angiogenesis in Cancer
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
CDH1 Down regulation Promotes Cancer Cell Migration and Metastases
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
EZH2 Methyltransferase Role in Cancer
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> CEBPA/FOXO1A Expression Targets
IGF2 -> CEBPA/FOXO1A Expression Targets
IGF2/MEF/MYOD Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
CD19 -> NF-kB Signaling
AGER -> NF-kB Signaling
AGER -> CREB/SP1 Signaling
CD19 -> JUN/ELK Signaling
ICAM2 -> CTNNB/FOXO/STAT3 Signaling
FcIgER -> ELK-SRF Signaling
InsulinR -> CTNNB/FOXA/FOXO Signaling
InsulinR -> ELK/SRF/SREBF Signaling
IGF1R -> CEBPA/FOXO1A Signaling
IGF1R -> MEF/MYOD/MYOG Signaling
FibronectinR -> CTNNB Signaling
FibronectinR -> NF-kB Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
MacrophageR -> CEBPB -> NF-kB Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> FOXO3A Expression Target
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
Fibrinogen Expression Targets
IL7R -> FOXO/NF-kB Signaling
IL15R -> NF-kB/NFATC Signaling
IL2R -> ELK/SRF/MYC Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL7 Expression Targets
IL15 Expression Targets
IL12B Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
PAF/Gq -> NF-kB Expression Targets
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> FOXO3A Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> NF-kB Signaling
DLL4 Expression Targets
ADAM17 Expression Targets
JAG1 Expression Targets
DLL1 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFB -> FOXO3A Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> FOXO3A Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
PDGFR -> FOXO3A Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
NTS Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
NPY Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
PDCD1 -> NF-kB Expression Targets
PDCD1 -> NFATC Expression Targets
PDCD1 -> AP-1 Expression Targets
AngiopoietinR -> AP-1 Signaling
AngiopoietinR -> FOXO Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> FOXO/MYCN Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> FOXO3A Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
FOXO1 Signaling
MERTK Signaling
Ras Signaling
TGF-beta Signaling
AXL Receptor Tyrosine Kinase Signaling
mTOR Signaling
TNF-alpha/TNFRSF1B Signaling
KRAS Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
HRAS Signaling
ERK/MAPK Canonical Signaling
Hedgehog Family Signaling
T-Cell Receptor -> NF-kB Signaling
TGFA -> FOXO3A Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13B Expression Targets
TNFRSF5/13B -> NFATC1 Signaling
Thrombopoietin -> SPI1 Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> FOXO3A Expression Target
TLR1 -> 2/6 Expression Targets
TLR1/2/6 -> NF-kB Signaling
ROS in Neutrophil Mediated Cell Damage
ROS in Triggering Vascular Inflammation
Glutamate Mediated Neurotoxicity
ROS and RNS in Vasoconstriction and Vasodilation Regulation
Ca2+ Cytosolic Overload
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFC -> CTNNB Expression Target
VEGFA -> FOXO3A Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> CTNNB Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> FOXO3A Signaling
n
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Neighbors of PI3K
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
H2A-K120, H2A-K119 and H3-K4
Epigenetic Modifications of H2A-K120, H2A-K119 and H3-K4
3_Increased proliferation of sebocytes in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Osteoblast-mediated bone demineralization
1_Formation of cysts in polycystic kidney disease
2_The role of endothelial cells in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
2_Cardiomyocyte hypertrophy
4_Endothelial cells repress vasoconstriction in hypertension
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Triglyceride storage in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
4_Tax-induced disruption of the G1/S transition in HTLV-1 infected T-cell
3_1_Beta-cell proliferation and compensation: proliferation
1_2_Insulin synthesis and secretion: insulin secretion
1_1_Insulin synthesis and secretion: insulin processing and storage
3_3_Beta-cell proliferation and compensation: recovery
4_2_Insulin resistance: inflammation-related insulin resistance
4_1_Insulin resistance: insulin signaling
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
1_Microangiopathy in diabetic neuropathy
1_Glutamate and calcium excitotoxicity of motor neurons in ALS
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
2_1_General pathways of thyroid hormone signaling
1_cd_Amyloid-beta in Alzheimer's disease
Model of PPARG signaling in psoriais (tested)
DIPG overview_1 (histones)
HRAS->RAF->MAPK1/3
Interleukin-17 and interleukin-22 signaling in psoriasis

Source curated
KEGG mapped on proteins

MedScan ID 12811969
12900011
12001028
12116303

LocusLink ID 8651
5144
25467
3480
10657
140635
74769
16367
25513
361632
104709
18708
362046
18709
18704
18705
85243
18706
3643
18707
155871
25
5286
5287
27
5288
5289
4233
3815
26377
2321
5159
16337
289021
5294
5295
5296
24408
20848
5290
5291
5293
29496
3667
27071
18576
298947
29741
384783
558
20662
13857
26362
57317
116720
320207
14388
65052
18710
24954
1436
12978
2885
140694
1398
613
8503
1956
6461
20401
3190
14083
6464
9610
71233
2260
12747
366508
30955
5925
26060

Alias phosphatidyl-inositide 3-kinases
phosphatidyl-inositol (PI) 3-kinase
phosphoinositide 3-kinase complexes
phosphatidylinositol (PI) 3-kinase
phosphoinositide 3-kinase complex
phospho-inositol 3 kinases
phosphoinositide (PI) 3 kinases
phosphatidylinositol (PtdIns) 3-kinase
phosphatidyl inositol kinase
PI3K complexes
phosphatidylinositide 3-kinases
PI3-kinases
phosphatidylinositol kinase
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
1-phosphatidylinositol 3-kinase
PI3K complex
phosphatidylinositol 3-kinases
phosphoinositide 3 (PI-3)-kinase
phosphoinositide (PI) 3 kinase
phospho inositide 3-kinases
1-phosphatidyl inositol 3-kinase
PtdIns-3-kinase
PI3Ks
phosphatidylinositol 3-kinase
phosphoinositide 3-kinase
phosphatidylinositol kinases
phosphoinositide 3-OH kinases
phosphatidyl inositol kinases
phosphatidylinositol-3-OH (PI-3) kinase
phospho-inositol 3 kinase
1-phosphatidylinositol 3-kinase complexes
phospho inositide 3-kinase
phosphatidyl-inositide 3-kinase
1-phosphatidylinositol 3-kinases
PI3K
phosphatidylinositide 3-kinase
phosphatidylinositol-3-OH kinase
phosphatidyl inositol 3-kinases
PtdIns-3'-kinase
1-phosphatidylinositol 3-kinase complex
phosphatidyl inositol 3-kinase
PI3-kinase
phosphoinositide 3-kinases
phosphatidylinositol 3 (PI3) kinase
phosphoinositide 3-OH kinase
PtdIns-3-kinases
PtdIns 3-kinase type 3
phosphatidil inositol 3-kinase
PI3-K
class III phosphatidylinositol 3-kinases
phosphatidyl- inositol (PI) 3-kinases
phosphoinositide (PI)-kinases
phosphatidylinositol 3 kinase class 3
phosphatidylinositol 3-kinase, class IIIs
phosphotidylinositol 3-kinase
phosphatidylinositol 3-kinase, class I, catalysts
PI 4-kinase
phosphoinositide (PI) 3 kinase
phosphatidylinositol 4-kinase
phosphoinositide-3-kinases, class 3
class III PI3-kinases
ATP:1-phosphatidyl-1D-myo-inositol 3-phospho-transferases
phospho-inositol 3 (PI-3) kinase
PtdIns-3-kinase type 3
phosphoinositide (PI) 3 kinases
phosphatidylinositol 3-kinase activity
phosphatidylinositol 3-kinase, class III
class III PI3-kinase
phosphatidylinositol 3-kinase, class I
phosphatidyl inositol (PI) kinase
phospho-inositol 3 (PI-3) kinases
phosphatidylinositol-3 (PI) kinase
phophatidylinositol-3 (PI-3) kinases
PI kinase
phospatidylinositol-3-kinases
phosphatidyl-3-inositol (PI-3) kinases
phospho-inositol 3 (PI-3) kinases
phosphatidylinositol kinase (|phosphorylating)
class I PI3 kinases
phosphoinositide (PI)-kinase
phosphatidylinositol (PtdIns) 3-kinases
phophatidylinositol-3 (PI-3) kinases
type II phosphatidylinositol kinase
phosphoinositide-3-kinase, class III
phospatidylinositol-3-kinase
2.7.1.137
type I phosphatidylinositol kinases
PI3-Ks
ATP:1-phosphatidyl-1D-myo-inositol 3-phospho-transferase
PI3 kinase
phophatidylinositol-3 (PI-3) kinase
C2-domain-containing phosphoinositide 3-kinases
phosphatidylinositol 3-kinase, class II
phosphatidylinositol 3-kinase activity, class I
phosphatidylinositol 3 kinase
phosphatidylinositol (PI) 3-kinases
PI3 kinase type 3
phosphatidyl inositol (PI) kinases
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
phosphatidylinositol-3 (PI) kinases
phosphatidylinositol-3-OH (PI-3) kinases
phosphoinositide 3 (PI-3)-kinases
PI3kss
phosphatidylinositol 3 (PtdIns-3) kinase
phosphatidylinositol 3-kinase, class I, catalyst
phosphatidylinositol 3-kinase activity, class II
phosphoinositide (PI)-kinase
phosphatidyl-3-inositol (PI-3) kinase
phosphatidylinositol-3-OH (PI-3) kinases
phosphoinositide (PI)-kinases
phosphatidylinositol-4-phosphate 3-kinases
type III phosphoinositide 3-kinases
phosphatidylinositol-3-OH (PI-3) kinase
phosphotidyl inositol 3-kinases
PI3K type 3
phosphatidyl-3-inositol (PI-3) kinase
phosphatidyl- inositol (PI) 3-kinase
phosphatidyl inositol (PI) kinase
phosphatidylinositol 3 (PI3) kinases
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferases
PtdIns-3 kinase type 3
class I phosphatidylinositol 3-kinase
phospho-inositol 3 (PI-3) kinase
phosphatidyl inositol (PI) kinases
1-phosphatidyl inositol 3-kinases
phosphatidyl-3-inositol (PI-3) kinases
class III PI3Ks
phosphatidylinositol-3 (PI) kinases
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferases
C2-domain-containing phosphoinositide 3-kinase
phophatidylinositol-3 (PI-3) kinase
phosphatidylinositol-4-phosphate 3-kinase
phosphatidylinositol 3 (PtdIns-3) kinases
phosphatidil inositol 3-kinases
class I PI3K
1-phosphatidylinositol 4-kinase
class III PI3K
2.7.1.153
type I phosphoinositide 3-kinases
Vps34p
type I phosphoinositide 3-kinase
phosphatidylinositol 3-kinase activity, class III
class I phosphatidylinositol 3-kinases
Type II phosphoinositide 3-kinase
type III phosphoinositide 3-kinase
class II phosphatidylinositol 3-kinase
2.7.1.154
phosphoinositide-3-kinase
PIK3C3
PI3 kinases
phosphotidylinositol 3-kinases
phosphoinositide 3 (PI-3)-kinase
class I PI3Ks
phosphatidylinositol-4,5-bisphosphate 3-kinase
phosphoinositide-3-kinase, class 3
class I PI3 kinase
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
phosphatidylinositol-4,5-bisphosphate 3-kinases
phosphatidyl-inositol (PI) 3-kinases
class II phosphatidylinositol 3-kinases
class III phosphatidylinositol 3-kinase
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferases
phosphatidylinositol-3 (PI) kinase
PI3-kinase type 3
phosphatidylinositol 3 kinases
type I phosphatidylinositol kinase
phosphotidyl inositol 3-kinase
phosphoinositide 3 (PI-3)-kinases

CAS ID 37205-54-2
141176-94-5
103843-30-7

EC Number 2.7.1.154
2.7.1.67
2.7.1.137
2.7.1.153

GO ID 0005942
0016303
0004429

Cell Localization Cytoplasm

LocatorString pmquery:curcumin prostate cancer
pmquery:egfr+transactivation

EC Number ID 2.7.1.137