Protein MAPK1

URN urn:agi-llid:5594
Total Entities 0
Connectivity 21005
Name MAPK1
Description mitogen-activated protein kinase 1
Notes This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Alzheimer's Disease
Osteoarthritis
Skin Aging
Oncogene Induced Cellular Senescence
Melatonin Effects on Circadian Cycle
mTOR Signaling
mTOR Signaling Hyperfunction
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Leptin and CCK8 Activate Nodose Ganglia Neuron
Insulin Influence on Glycogenesis
Insulin Synthesis in beta-Cell
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Norepinephrine Release Regulation
CRH Secretion Regulation
Insulin Signaling
Prolactin Production
POMC Secretion in adenohypophysis
Thrombopoietin Receptors Signaling in Platelet Maturation
Mineralcorticoids Secretion Regulation
Toll-like Receptors Act through MYD88-TIRAP Signaling
TLR4 Signaling in Leukocytes
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
V(D)J Recombination Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
MC1R in anti-Inflammatory Signaling
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Potassium Flux Regulation
Nociception Expression Targets Signaling
Vascular Motility
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA2C/ADRB2 -> Vasoconstriction
ADRA2C/ADRB2 -> Synaptic Endocytosis
ADRB1 -> Prostaglandin Generation
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD1/5 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR7 -> IL6 Production
HTR5 -> TNF Production
HTR4/6/7 -> Cation Channels
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
CHRNA7 -> NOS1 Production
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
P2RY11/13/14 -> IL8/10 Production
Luteinizing Hormone in Oocyte Meiotic Resumption
Melatonin in Cell Survival and Antioxidant Response
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Vitamine D Deficite and Dentin Formation
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
Cell Cycle Overiew
G0/G1 Phase Transition
Gap Junction Assembly
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Endothelial Cell Dysfunction in Arterial Hypertension
Aldosterone Synthesis Chronic Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Endothelial Cell Dysfunction in Pulmonary Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
BMP2 and Canonical WNT Signaling in Pulmonary Artery Endothelial Cells
Myocardial Remodeling
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Contraction Due Vasospasm
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Proteins with Altered Expression in Melanoma
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
Proteins Involved in Melanoma
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
AGE Related Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hyperparathyroidism, Neonatal Severe
RET1 Mutation in Hyperparathyroidism
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
Graves Ophthalmopathy
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Hypoparathyroidism, Primary
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Proteins Involved in Obesity
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
GUCY2C Signaling in Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Dendritic Cell Function in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Follicular Lymphoma
Proteins Involved in Follicular Lymphoma
Hodgkin Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TRPM7/8 in Pancreatic Adenocarcinoma
TGFBR Signaling in Pancreatic Neoplasms
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
Eosinophil Activation and Degranulation in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Neutrophil Degranulation via FPR1/IL8
Antigen-Presenting Cell Role in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Airway Epithelial Cell Dysfunction
Osteoclast Activation in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Ovulation Block
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Dendritic Cell Dysfunction in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
WHIM Syndrome
Dentin Formation Disruption
CCR5 Signaling in Macrophages
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Majeed Syndrome
Cowden Syndrome
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
Gluten Impact on Neuronal System (Hypothesis)
Proteins Involved in Autistic Disorder and Aggression
Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
Proteins Involved in Epilepsy
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Glioblastoma, Primary
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Medulloblastoma
Postsynaptic Neuron Activation
Prostaglandin E2 Synthesis Activation via Glutamate in Familial Hemiplegic Migraine
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in Female Infertility
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
MIF Role in Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
HPV E4 Contribution to Life Cycle of Virus and Cell
Fatty Acid Synthase (FASN) Signaling
Androgen Receptor/FKBP5 Signaling
Prostate Cancer
RNase L Signaling in Prostate Cancer
TRPM8 Effects in Prostate Cancer (Hypothesis)
Proteins Involved in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Proteins Involved in Glaucoma
PGF2-alpha Effect on Treatment
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
Proteins Involved in Hearing Loss
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Polycystins Mutation Effects in Cystic Kidney Disease
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Sertoli Cells Dysfunction Causes Male Infertility
Proteins Involved in Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
GLP1R -> ARRB1 Signaling
IGF1R -> ARRB1/ERK1/3 Signaling
AGTR1 -> ARRB1/ARRB2 Signaling
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CHRNA7 -> CREB Signaling
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
GCG Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
Elevated Receptors -> Expression Targets in Liver
EGFR -> Expression Targets in Colon
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
MTOR/TORC in Cancer Cell Motility and Invasion
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Lactate as a Signaling Molecule in Cancer Cells
Treg Cells Promote Immunosuppression in Cancer Immune Escape
EZH2 Methyltransferase Role in Cancer
HCAR1/HCAR2 -> MAPK Signaling
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
AGER -> CREB/SP1 Signaling
NCAM1 -> CREB/ELK/SRF/MYC Signaling
CD19 -> JUN/ELK Signaling
PECAM -> SP1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
InsulinR -> ELK/SRF/SREBF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
IL6R -> CEBP/ELK/SRF Signaling
IL2R -> ELK/SRF/MYC Signaling
IL1R -> NF-kB Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL16 -> AP-1 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
S1P Expression Targets
PGE1 Expression Targets
EGFR-> Expression Targets in Lymphoid System and Blood
MTNR1 Signaling
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
Adenosine Expression Targets
OR1A1 -> GNAS Signaling
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> NFATC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
MERTK Signaling
Ras Signaling
TGF-beta Signaling
AMPK Signaling
AXL Receptor Tyrosine Kinase Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
ERK/MAPK Canonical Signaling
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pathway 3
e
ace2
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Inflammation in keratinocytes in the pathology of acne
2_Hyperseborrhea in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Osteoblast-mediated bone demineralization
1_Formation of cysts in polycystic kidney disease
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
3_Human papilloma virus E4 and E5 proteins in viral reproduction
1_1_Insulin synthesis and secretion: insulin processing and storage
4_1_Insulin resistance: insulin signaling
3_Islet beta-cell destruction in T1D
1_Microangiopathy in diabetic neuropathy
2_1_General pathways of thyroid hormone signaling
drug-target molsynthesis
Model of PPARG signaling in psoriais (tested)
public list
New Pathway
HRAS->RAF->MAPK1/3
KRAS->RAFs->MAPK1/3
NRAS->RAFs->MAPK1/3
Other RASs-RAFs-MAPK1/3
mapk1
New Pathway
mapk1 direct regulators
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes Associated with Systemic Lupus Erythematosus
Proteins Involved in Cowden Syndrome

Source GO component
ResNet
curated

MedScan ID 5594

LocusLink ID 5594
26413
116590
19093
106324
360144
326413
98012
327672
106103
74546

Alias ERK
MAP kinase 1
extracellular signal-related kinase
Extracellular signal-regulated kinase II
extracellular signaling-regulated kinase
mitogen activated protein kinase 1
AA407128
protein kinase, mitogen activated kinase 1
AU018647
protein kinase ERK2
MAP kinase isoform p42
MAP kinase ERK2
protein tyrosine kinase ERK2
ERK2 protein kinase
Extracellular regulated kinase II
p42 MAP kinase
MAP kinase II
p42 ERK
extracellular signaling-related kinase 2
PRKM1
extracellular signal-related kinase 2
ERK2 MAP kinase
extra-cellular signal-regulated kinase
pERK
PRKM2
9030612K14Rik
extracellular signal-regulated kinase (ERK) 2
mitogen activated protein kinase p42
ERK2
p42 mitogen activated protein kinase 1
RIKEN cDNA 9030612K14 gene
extracellular signal-regulated kinase
MK01_HUMAN
Mitogen-activated protein kinase 2
extra-cellular signal-regulated kinase (ERK) 2
Mitogen-activated protein kinase II
9030612K14
MAPK2
p41 MAPK
Extracellular regulated kinase 2
extracellular signaling-regulated kinase 2
p42 mitogen activated protein kinase
p42(mapk) kinase
ERT I
Extracellular regulated kinase
P42MAPK
OTTMUSP00000022009
C78273
MAP kinase 2
mitogen activated protein kinase ERK2
PRKM I
ERT1
Extracellular signal-regulated kinase 2
OTTHUMP00000174492
OTTMUSP00000021888
MAPK1
MAP kinase I
extracellular signaling-related kinase
OTTMUSP00000022010
mitogen activated protein kinase I
MAPK I
p38
p40
p41
ERK-2
p41mapk
p42-MAPK
MAPK 2
mitogen-activated protein kinase 1
MAPK 1
extracellular-signal-regulated kinase 2
MK01
extracellular signal-regulated kinase-2
MAP kinase I
MAP kinase 1
C78273s
Niddm5s
scaffold
Extracellular signal- regulated kinase 2
Non-insulin-dependent diabetes mellitus QTL 5
chromosome
MAPK p42
Rsk-1
expressed sequence c78273
expressed sequence au018647
zERK2
Niddm5
expressed sequence aa407128
Non-insulin-dependent diabetes mellitus QTL V
protein kinase, mitogen-activated I
Extracellular signal- regulated kinase II
ERK2 (MAPK1)
p40-ARC
p41-ARC
extracellular-signal-regulated kinase 1
protein kinase, mitogen-activated 1

EC Number 2.7.11.24
2.7.1.-
2.7.1.37

GO ID 0005524
0004707
0004708
0008353
0003690
0016301
0031435
0019902
0001784
0004674
0008134
0050853
0060020
0038127
0070371
0038095
0038096
0000165
0050852
0000187
0000186
0007568
0006915
0007411
0061308
0072584
0007049
0006974
0034198
0071276
1903351
0097011
0071310
0034614
0071356
0007268
0006935
0019858
0046697
0015966
0060324
0008543
0035556
0060716
0007611
0031663
0060291
0060425
0033598
0045596
0043312
0042473
0018105
0018107
0030168
0060045
0030335
0010628
0010800
0042307
0051973
1904355
0032212
0045893
0045727
0006468
0051090
0090170
0030641
1900034
0051493
2000641
0010468
0030278
0014066
0031647
0032872
0070849
0043627
0043330
0035094
0019233
0007165
0051403
0048538
0030878
0060440
0016032
0005794
0030424
0035578
0005901
0005737
0005856
0005829
0032839
0005769
0005576
1904813
0005925
0005770
0005815
0005739
0072686
0005654
0005634
0043204
0005886
0014069
0032991
0031143
0000166
0004672
0019901
0016740
0009887
0007507
0014032
0016310
0032496
0009636
0006351
0016020
0008284
0003677
0060397
0000189
0006950
0070062
0015630
0043234
0002755
0002756
0007265
0035666
0007596
0034605
0007173
0045087
0008286
0048011
0007264
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0048010
0016772
0019048
0005730
0005819
0008063
0006917
0034130
0033267
0042221
0023014
0005622
0007243
0044419
0005626
0005625
0030528
0008152
0016908
0045941
0023034
0005515
0003700
0007242
0004682
0004713
0004691
0007166
0033160

KEGG ID hsa:5594
mmu:26413
rno:116590

MedLine Reference 9261178
12783880
17161379
12478298
11306815
7816602
15314156
16616413
16368546
7876160
15247297
15494312
15778391
17164422
12218048
12444202
17615382
12218045
16294323
12408764
11994544
17128418
9325171
12792650
12466851
14764702
12637525
12730054
16510265
9430688
15721302
16950125
12076252
8618896
12562867
14551213
14966273
15861134
15033452
17131384
11884401
14620918
17297454
15923189
15240686
15574735
12629153
16943367
14675480
17337702
14741752
9872331
1648701
8221888
15033443
11544199
16321971
16729973
8960373
14568551
12538595
15836771
11805112
12727216
16278291
16047735
14744933
14654779
17050000
10725249
11739747
15489642
15899886
10330152
16278684
17105191
16272159
9199504
10706702
14551204
16291755
17522155
11914583
14636584
16865246
15588985
15632082
15632084
16906226
15937334
17038630
15128788
16538383
11920199
11841548
17142261
17237147
10194762
15607907
11961297
1712480
14511403
15249224
17267664
11042159
11878930
11952164
9841865
16141211
14742298
17317777
16116448
16980614
12592337
14688221
16139272
16282323
16980607
15595556
11805108
15691764
12505790
8631994
16280323
17574041
14576154
16617096
12837289
12774925
17363453
9621077
12049732
15616583
17149612
15991247
11937539
12773577
14605008
15664191
11937531
17309799
17624368
14702039
1330687
17410437
14499647
12800247
16887830
14729955
9030579
11205744
12584202
16514068
16287813
14670631
15327774
9060415
10942774
11788583
12175859
16988247
10737616
15030409
12477973
12603851
15030407
16794828
12661038
10206983
15731359
12637339
14997206
16081426
16635502
16914058
11226163
16730415
11702783
12718435
12482669
16887817
14587029
15563472
12538349
15247230
8290275
15030400
12388422
12388423
11260070
17088403
17417601
15128760
16687572
12529294
16707097
12393542
11889128
9013873
16239230
16106045
12039864
17113581
16795048
15292252
16399079
9632734
15273746
16237170
12811826
17068135
12058028
12508271
17396120
16198290
12960100
12095140
14762791
8626447
12754301
17068339
17507094
17371162
14597424
12894225
10949032
11726647
15778365
12592382
14963006
10915800
17442737
12223545
15930378
15305288
12095152
17215072
7535768
17068343
11943771
12612072
12091386
16774848
7797459
16616009
12081893
15655348
12477932
12081892
12925581
15292226
11923300
16926156
15355986
10405182
16670094
16395709
12556561
9592082
11866440
10993892
10762698
8626452
12637502
14501944
10617468
14605001
12032311
16226508
17543571
15157810
15654082
10996427
17499702
15975921
11830463
16305822
12077112
14575703
12093745
17583675
14766231
12832467
12473660
9779826
17709754
15383658
17496918
11748628
16322063
17016429
15728359
9774969
11408587
15121188
15569927
14500714
10635328
17303384
10224087
8552640
17303382
9149902
15226823
12881410
9558095
14672918
15081531
8675207
9725910
12930843
15757891
17525735
15746430
8816480
15253667
9771888
12351702
12097495
15282307
15069082
15016620
15537893
9528769
12183542
16644735
17192257
17081988
16912315
16641100
15020650
14502223
15928662
17081983
14512869
16283431
11744690
17294242
15544353
9535909
12169734
12937895
12536241
9535905
15284227
12149268
17105770
17149706
11668049
15537896
12826588
8407983
12391149
14534235
14593093
12759139
16820791
15851480
10521505
16207820
11789669
15545519
14715940
1649458
8900182
15116093
16273204
15072963
12177807
11861509
12972619
10567572
15951569
16198352
16614081
16973750
11896055
12167619
12223406
8506364
16414009
12794156
15351692
14580718
12955074
15882975
12441075
11279280
8615903
11044099
15203192
11741541
14741046
12435482
11971971
15782199
12972603
11352917
12491158
14592976
10347142
15542607
12871576
9223324
7939721
12663469
16504549
8248197
14517212
12883725
16288922
12849998
16972271
12663671
17560563
17265428
12837293
11266467
10958679
12149432
12487375
12149431
16820947
15242988
17183546
15054132
16569214
11776327
17469127
9199329
15037631
10757792
16045329
16581800
9535927
12880367
12618431
14676843
15542825
15322023
10558995
17284251
14701865
16044092
14701866
14718391
10627507
12206715
12952860
12006497
15860728
15169786
12618428
12057008
14676217
15963972
15031289
17510316
14570886
14638694
9155017
16813525
11684667
16934944
15485655
14691575
15782123
14506249
12676937
15358203
11781324
15064239
16781693
15173174
17308007
17198696
11840343
8896447
17600551
14744867
15897893
9565682
10197981
9353295
15546878
14622137
16253958
10509564
15322069
12167697
15572037
8639570
16691571
12576423
12048211
12387894
8389479
15625301
10230405
1659995
16434965
15225643
10779345
16039615
12963735
12464620
15356145
11756441
9405468
11114188
15249196
17388789
17581212
12161424
7878028
14676207
9298898
12971962
9343414
12821670
16806079
10780709
14655753
11278335
11823456
17577579
12200131
12220517
12540369
15671028
8806671
11579140
11714707
16873684
7566346
11493009
12805214
11481231
12697810
12130649
11549292
14769808
15890751
11217851
15021912
12540563
16286470
15210734
11751611
12947325
17046812
16492667
17005865
8994038
17464174
12226093
17427197
12349907
14636891
11134045
11994045
11844932
15917991
16944316
16251435
12460991
15582777
12665801
14983993
15041276
15243131
11904305
12801888
15880942
15502830
12082091
14622970
17464186
12140374
15985432
16954218
17548467
11847101
12935895
15964695
15899793
17458890
9832145
15347670
15078890
1319925
12239215
11409876
14671106
14714552
9440696
10733581
16177070
12393899
12529330
16763222
10866661
9388255
17317670
12611773
16621802
15721486
14522949
14988413
12151396
16156666
12220502
12469121
15777705
16373414
11307167
14970210
8083223
10660621
16979915
11409852
14970219
12081562
14985505
12917419
15469737
15118098
16420578
11489891
8384717
16131083
17244536
15184391
9649500
15739119
16149052
16897432
15071597
17333127
12050114
15078886
15040022
16888810
8444355
17015703
12379481
15967790
15371543
15967991
12072567
16805921
8208531
11832339
17582742
15128676
16857343
16978658
15187168
12356731
7619503
15229233
10051431
12832284
16686604
12038794
8794306
15753041
17145771
8626571
16432225
16941494
12606501
16705745
17074386
16714296
16837555
9915826
8889548
17107998
12623863
8626561
1849075
7569900
11583024
11606045
15489334
17212589
17513610
10337614
16814421
9335504
15489336
15865443
12356755
15772134
10187842
15811423
15102471
15241487
10490027
16049186
15187147
12700162
15155723
12087100
12419216
15592455
12705474
12555071
9792705
11839761
12763138
12535947
16611738
7499190
12456688
17172448
12736212
12079429
17369402
17382881
15647743
12943720
16808899
15379552
14960303
11350735
16867183
17107949
14673008
10675333
12947314
12032872
12161450
11923482
11891214
15975997
11013076
10349636
16467359
8107865
16476765
12699904
17522999
11825889
11181841
12438317
11866540
11741894
15583728
10692442
12821662
15051723
11350938
16242072
17442811
12042309
11278799
17418417
14715628
8939914
17658891
17504381
16848763
16094384
12957654
15557324
12446729
12937136
15851026
12594221
11416124
1540184
17418118
17512500
15059773
17341442
15928037
15617763
12097372
16051177
17068198
15748847
16020276
15125795
17443665
16641227
16624816
11076861
15258148
11799072
17314319
15729360
15026121
16153436
11773377
12663502
17026958
16893669
16081808
14566055
14602725
12072413
12727980
12920127
15107845
17351113
12840032
9788880
11867630
9415407
15068691
16998804
7768935
15257182
15529758
12871860
17628608
12594266
12082107
17175230
12556484
15052686
8586671
12872135
12435397
11840291
10446219
16319118
8607977
15132979
14634061
12362243
10982368
14552884
16735500
16820883
17035635
15498890
9211903
14634064
12388473
15695173
16173113
15304367
15728253
16595703
10922068
16126730
17583725
17695723
9029147
14711824
14532121
12794004
16890158
17397260
16897752
15537391
14763996
8157000
11930938
12531514
16786433
8386592
14749824
11581251
15269220
17482686
1378617
12105188
16135819
12217325
15908120
12808090
9087672
16556602
12647296
12121974
16217033
10074203
12121979
17631144
12213812
17467311
16368932
9852579
15358166
11687663
9604935
12643788
16831126
9687510
16627622
9092573
12665511
17502994
12665513
14984009
15456767
15572149
16027724
11226259
11557582
16332685
17662006
9857190
15616014
15569628
16574793
10702794
2032290
15735702
11883936
15143154
14597699
7777512
15907834
15952796
17114285
9177225
12006386
7636214
12975377
15087455
11786537
15143165
10825211
16406609
16753021
16141073
16141072
16723731
15653762
14707138
16995340
12151316
15169891
17065231
16796978
17531530
15653554
11960991
12030372
12645629
14970190
12794087
14694183
10799874
16148006
16723512
16723511
15809051
12576315
15814736
12068299
70317
10910078
12624094
12810719
16533805
17620366
16723503
15173068
16209712
15629424
12921749
14985328
11876253
16242327
15713638
12450322
12810726
12897243
15610077
17641779
10706854
11875120
15964902
17022980
12682854
9628874
12690112
12690113
16877348
15669185
12054624
15184064
10419510

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Bos taurus
Human

Mouse chromosome position 16 10.53 cM
16 9.82 cM

OMIM ID 176948
61404
OMIM:176948

Rat chromosome position 11q23

Hugo ID 6871
HGNC:6871

Human chromosome position 22q11.22
22q11.21
22q11.2

Swiss-Prot Accession P28482
Q1HBJ4
Q499G7
P28482.3
P63085
P63085.3
P63086
P63086.3
A8CZ64
P27703
Q3V1U6
O35558
Q3UF82
Q922X7
MK01_MOUSE
MK01_HUMAN
Q1HBJ4_HUMAN
MK01_RAT

PIR ID JQ1400
S16444
A40033

GenBank ID NC_000022
NM_002745
NP_002736
NM_138957
NP_620407
NG_023054
AC245452
AP000553
AP000554
AP000555
CH471095
EAW59479
EAW59480
EAW59481
EAW59482
DQ508104
ABF47102
EU332852
ABY87541
HC462822
CBK51146
JX512449
AGC09596
AI004470
AK055080
AK057143
AK090869
AK295188
BAG58192
AK307615
BC017832
AAH17832
BC099905
AAH99905
BQ774391
DQ399292
ABD60303
EF565108
Z11694
CAA77752
Z11695
CAA77753
P28482
NC_000082
XM_006522147
XP_006522210
NM_011949
NP_036079
NM_001038663
NP_001033752
NM_001357115
AC154667
AC166346
AC166832
CH466521
EDK97435
EDK97436
EDK97437
D87271
BAA22620
AK013699
AK018549
AK035386
BAC29053
AK043621
AK048127
BAC33251
AK048159
AK087925
BAC40044
AK132241
BAE21053
AK148853
BAE28679
AK163692
AK192793
AK193161
AK193200
AK205643
AK209313
AK210736
AK211534
AK216848
AK218813
BB648734
BC006708
AAH06708
BC058258
AAH58258
D10939
BAA01733
X58712
CAA41548
P63085
NC_005110
XM_008768848
XP_008767070
NM_053842
NP_446294
XM_006248658
XP_006248720
XM_006248659
XP_006248721
AC_000079
AAHX01070431
AC110316
AC128500
CH473999
EDL77868
FQ211642
FQ222797
M64300
AAA41124
P63086
NC_018933
AMYH02038121
EU176323
ABW03774
EU831429
ACE87116
EU831522
ACE86441
AC_000038
AAHY01126102
AAHY01126103
AAHY01126104
AC_000154
ABBA01055067
ABBA01055068
ABBA01055069
ABBA01055070
ABBA01055071
XM_006248660
XP_006248722
AABR06069584
NT_011520
NW_001838745
NW_927628
AC_000065
CR621660
Q1HBJ4
Q499G7
NT_039624
NW_001030584
O35558
Q3UF82
Q922X7
NW_047358
NW_001084663
204056
BC133588
204055
94717602
337
BAB31269
82241457
33090821
149019720
20986528
20986529
74205494
Q6P023
20986531
20986530
40254655
40254654
AAI33589
53002
121945923
53001
NW_001513353
Q9D319
6754632
Dr.10452
AY922320
121945589
34869997
81879934
AAY57805
119554
NW_001493558
26330645
Q7ZW72
29477123
BM209765
26330646
51477137
51476066
AAH65868
71533985
123787871
23880
BC050169,BC065868
81881305
126010804
CAA78467
26339159
C78273
82247164
AAH50169
26339160
81908358
BG064270
23881
12858306
286076
52001075
52001076
23878
23879
2506067
2506068
2506069
NM_182888
AAA58459
2506065
2506066
NC_007315
ZDB-GENE-030722-2
Q4VH14
38080525
P46196
12858307
M84489
82226562
2506072
2506073
2506070
2506071
26089849
74221963
AA407128
Z14089
41351062
dre:360144
AI450767
17389605
17389606
12851161
27370563
82237383
220994
NP_878308
148665021
148665020
NT_086921
126007510
360144
BAB11813
66866303
NP_786987
AB030903
Q9DGR5
9836512
NM_175793
21749111
1169551
119579886
119579883
119579885
119579884
AL157438
16758698
16758697
13879457
NW_042725
148665019
BC065868
NT_082355
AU018647
87397
NW_000107
26092687
NC_007116
D87270
34849481
34849482
32168816
BX005237
51830781
D87264
26352828
D87265
26352827
D87266
D87268
D87267
D87269
BC050169

Swiss-Prot ID MK01_HUMAN
MK01_MOUSE
MK01_RAT
Q1HBJ4_HUMAN
Q499G7_HUMAN

Cell Localization Cytoplasm
Cytoskeleton
Spindle
Nucleus
Microtubule organizing center
Centrosome
Membrane
Caveola
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Extracellular
Intracellular

Ensembl ID ENSG00000100030
ENSP00000215832.6
ENST00000215832.10
ENSP00000381803.3
ENST00000398822.7
ENSMUSG00000063358
ENSMUSP00000111396.1
ENSMUST00000115731.9
ENSMUSP00000065983.7
ENSMUST00000069107.13
ENSMUSP00000156154.1
ENSMUST00000232611.1
ENSRNOG00000001849
ENSRNOP00000002533.6
ENSRNOT00000002533.7
ENSP00000215832
ENST00000215832
ENSP00000381803
ENST00000398822
ENSMUSP00000111396
ENSMUST00000115731
ENSMUSP00000065983
ENSMUST00000069107
ENSMUSP00000023462
ENSMUST00000023462
ENSRNOP00000002533
ENSRNOT00000002533
ENSMUST00000115731.8

MGI ID MGI:1346858
1346858
2146551
1921796
2146330
2146700
105919

RGD ID 70500
61404

Unigene ID Hs.431850
Mm.196581
Rn.34914
Hs.458104
Mm.456119
Dr.10452
Hs.324473
Bt.167
Mm.432724

Homologene ID 37670

Shape Sickle-vertex

IPI ID IPI00119663
IPI00199688
IPI00003479
IPI00474243
IPI00830966
IPI00780313

Chromosome position 11q23
22q11.2
16 9.82 cM

Microarray ID A_32_P746027
A_51_P263503
T119
I_961154
d10939_s_at
229847_at
A_14_P115905
1552263_at
A_65_P07849
A_52_P100088
C0177G06-3
aa242333_s_at
X58712.1
45715_at
A_23_P257895
224620_at
RC_F10496_f_at
A_43_P12954
208351_s_at
Z11695_at
msa.11014.0_f_at
976_s_at
1369078_at
55528_at
1453104_at
OH7884
NM_011949
212271_at
NM_053842
96438_at
A_51_P481788
93253_at
A_14_P105425
OR0839
727
A_65_P02960
1426585_s_at
M64300_at
Msa.52.0_at
Z11695
1419568_at
H38727_at
93254_at
H3074G02-3
A_24_P237265
226060_at
1552264_a_at
A_65_P03330
161583_at
R676
224621_at
AA120886_at
A_14_P114522

Homo sapiens Chromosome position 22q11.2

Ensembl Transcript ID ENST00000398822
ENST00000215832

ENSEMBL ENSG00000100030

FunctionalClass kinase
protein kinase
MAP kinase
protein binding
protein-tyrosine kinase
protein kinase CK2
phosphotyrosine binding
nucleotide binding
protein serine/threonine kinase
transferase
ATP binding
cAMP-dependent protein kinase

Molecular Function Kinase

Hugo Symbol MAPK1

Bos taurus Chromosome position 17

Mus musculus Chromosome position 16 A2
16
16 9.82 cM

KEGG pathway Chronic myeloid leukemia
Gap junction
Colorectal cancer
Melanoma
Melanogenesis
Natural killer cell mediated cytotoxicity
Focal adhesion
Long-term potentiation
Dorso-ventral axis formation
ErbB signaling pathway
Endometrial cancer
Glioma
GnRH signaling pathway
Long-term depression
Renal cell carcinoma
Non-small cell lung cancer
Axon guidance
Pancreatic cancer
MAPK signaling pathway
TGF-beta signaling pathway
mTOR signaling pathway
VEGF signaling pathway
Adherens junction
Thyroid cancer
Insulin signaling pathway
Type II diabetes mellitus
Regulation of actin cytoskeleton
Fc epsilon RI signaling pathway

ProteinAtlas SubcellularLocation Main location: Nucleus but not nucleoli; Other location: Cytoskeleton (Microtubules); Expression type: Staining; Reliability: Uncertain

State p

Rattus norvegicus Chromosome position 11q23

Ensembl Gene ID ENSG00000100030

Keyword cyclase
MEK
nuclei
ERK activator kinase
RAS small monomeric GTPase
kinase inhibitor
PKC
choline phosphatase
MAP kinase activity
3',5'-cyclic AMP synthetase
map kinase
cell matrix contact
cell-matrix contact
cytoplasm
map kinase kinase
protein serine/threonine kinase
SAP kinase
Adenylyl cyclase
nucleus
map kinases
JNK

ProteinAtlas NormalTissue Tissue: cerebellum; Cell type: cells in molecular layer; Level: Low; Expression type: APE; Reliability: Medium
Tissue: cervix
uterine; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: stomach
upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: tonsil; Cell type: non-germinal center cells; Level: High; Expression type: APE; Reliability: Medium
lower; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: adrenal gland; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: appendix; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: appendix; Cell type: lymphoid tissue; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: breast; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: cerebellum; Cell type: cells in granular layer; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cerebellum; Cell type: Purkinje cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: cerebral cortex; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cerebral cortex; Cell type: neuronal cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: cervix, uterine; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: colon; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: duodenum; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: epididymis; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: fallopian tube; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: gall bladder; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: heart muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: hippocampus; Cell type: glial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: hippocampus; Cell type: neuronal cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: kidney; Cell type: cells in glomeruli; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: kidney; Cell type: cells in tubules; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lateral ventricle; Cell type: glial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: lateral ventricle; Cell type: neuronal cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: liver; Cell type: bile duct cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: liver; Cell type: hepatocytes; Level: Low; Expression type: APE; Reliability: Medium
Tissue: lung; Cell type: macrophages; Level: High; Expression type: APE; Reliability: Medium
Tissue: lung; Cell type: pneumocytes; Level: High; Expression type: APE; Reliability: Medium
Tissue: lymph node; Cell type: germinal center cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lymph node; Cell type: non-germinal center cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: ovary; Cell type: follicle cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: ovary; Cell type: ovarian stroma cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: pancreas; Cell type: exocrine glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: pancreas; Cell type: islets of Langerhans; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: parathyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: placenta; Cell type: decidual cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: placenta; Cell type: trophoblastic cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: prostate; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: rectum; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: salivary gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: seminal vesicle; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: skeletal muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: small intestine; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: spleen; Cell type: cells in red pulp; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: spleen; Cell type: cells in white pulp; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: stomach, lower; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: stomach, upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: testis; Cell type: cells in seminiferus ducts; Level: High; Expression type: APE; Reliability: Medium
Tissue: testis; Cell type: Leydig cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: thyroid gland; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: tonsil; Cell type: germinal center cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: urinary bladder; Cell type: urothelial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: vagina; Cell type: squamous epithelial cells; Level: High; Expression type: APE; Reliability: Medium

LocatorString pmquery:egfr+transactivation
pmquery:curcumin prostate cancer
pmftq:achondroplasia
gscquery:achondroplasia
pmquery:prevacid, prilosec (omeprazole) 2002:2010[PDAT]

State Description Transcript Variant: This variant (2) contains a different 3' UTR region, however, encodes the same protein as compared to variant 1.
Transcript Variant: This variant (1) contains a different 3' UTR region, however, encodes the same protein as compared to variant 2.