Protein TICAM1

URN urn:agi-llid:10532
Total Entities 0
Connectivity 1168
Name TICAM1
Description toll-like receptor adaptor molecule 1
Notes This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Primary Cell Localization Cytoplasm
ObjectType Protein

Pathway Cortisol in Resolving Inflammation
NOD-like Receptors
Antiviral Signaling through Pattern Recognition Receptors
TLR4 Signaling in Leukocytes
T-Cell Independent B-Cell Activation
Toll-like Receptors in Sterile Inflammation
Necrosis
MC1R in anti-Inflammatory Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Dendritic Cells Function in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Myocardial Infarction
MAVS in Antiviral Innate Immune Response in Myocarditis
Proteins Involved in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
Celiac Disease
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Antiphospholipid Syndrome
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Club-Cell Role in Asthma
Antigen-Presenting Cell Role in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Airway Epithelial Cell Dysfunction
Monocytes Function in Gout
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Toll-like Receptors (TLR) in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
HMGB1 and IL1B in Neuroinflammation
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
TLR3 Role in Retinal Pigment Epithelial Cell
Proteins Involved in Otitis Media
Alveolar Macrophages Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
NFKB Canonical Signaling Activation in Cancer
NF-kB Canonical Signaling
TLR3 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR4 -> IRF Signaling
TLR3 -> IRF Signaling
TLR3 -> NF-kB Signaling
pathway 4
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
dsRNA induces innate immunity and INFs in alveolar cells
Dendritic Cell Activation in COVID19
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Neuron and Schwann cell death
Model of PPARG signaling in psoriais (tested)

MedScan ID 10532

LocusLink ID 10532
148022
106759
363328

Alias TICAM I
OTTMUSP00000017974
TIR domain-containing adaptor protein inducing IFN-beta
toll interleukin 1 receptor domain containing adaptor inducing interferon beta
LOC148021
LOC224899
AW547018
PRVTIRB
IIAE6
TICAM1
PRVTIRBs
CL24751
proline-rich, vinculin and TIR domain-containing protein B
AW046014
toll-like receptor adaptor molecule 1
LOC193797
TRIF
toll/interleukin-1 receptor domain-containing adaptor protein 1
LOC363328
TIR domain-containing adaptor molecule 1
MGC35334
TIR domain containing adaptor inducing interferon-beta
MyD88-3
TICAM-1
TIR domain-containing adapter protein inducing IFN-beta
putative NF-kappa-B-activating protein 502H
toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
TIR domain-containing adapter molecule 1
TIR domain-containing adaptor inducing interferon-beta
toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
TIR domain containing adapter inducing interferon-beta
toll-like receptor adapter molecule 1
toll/interleukin-1 receptor domain-containing adapter protein 1

GO ID 0019901
0007249
0002756
0035666
0097190
0071222
0140052
0051607
0006954
0045087
0031663
0002281
0070266
0034128
0030890
0043123
0051092
0010508
0045080
1900017
0010628
0045359
0032755
0002735
0032816
0045429
0032092
0031398
0032760
0043496
0043330
0034138
0016032
0005776
0005829
0010008
0005739
0097342
0006915
0002376
0050871
0032481
0032496
0005737
0031410
0034142
0007165
0008624
0005515
0008063
0004871
0002224
0002755
0034130
0034134
0005886
0009615

KEGG ID hsa:148022
mmu:106759

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 17

OMIM ID 607601
614850

Rat chromosome position 9q12
9

Hugo ID 18348
HGNC:18348

Human chromosome position 19p13.3

Swiss-Prot Accession Q8IUC6
Q8IUC6.1
Q80UF7
Q80UF7.1
B3Y691
O75532
Q86XP8
Q96GA0
Q3UDB7
Q3UP66
Q6P6J2
Q8CIB7
Q8JZV0

GenBank ID NC_000019
NM_182919
NP_891549
NG_031998
AC027319
CQ871232
CAH56797
AB086380
BAC55579
AB093555
BAC44839
AB097023
BAC77376
AB446484
BAG55261
AF070530
AAC28630
AF492646
AAO85488
BC009860
AAH09860
BC035331
BC136556
AAI36557
BC136557
AAI36558
BX349282
CA308725
DR000002
Q8IUC6
NC_000083
NM_174989
NP_778154
AC026385
AB091053
BAC55581
AK054219
AK083836
AK086237
AK089679
AK143766
BAE25531
AK150150
BAE29344
AK155245
BAE33144
AK155906
AK171578
AK205957
AK217234
BC033406
AAH33406
BC037048
AAH37048
BC062191
AAH62191
BC094338
AAH94338
Q80UF7
NC_005108
XM_008766802
XP_008765024
XM_017596709
XP_017452198
AC_000077
XM_008757917
XP_008756139
XM_017603789
XP_017459278
AABR07066529
AAHX01058012
NC_018930
ABBA01056040
ABBA01056041
AMYH02035304
AMYH02035305
AC_000151
NT_011255
NW_927173
NW_001838477
AC_000062
CR592986
NT_039649

Swiss-Prot ID TCAM1_HUMAN
TCAM1_MOUSE
B3Y691_HUMAN

Cell Localization Cytoplasmic vesicle
Autophagosome
Cytoplasm
Cytosol
Mitochondrion
Cytoplasmic vesicle, autophagosome

Ensembl ID ENSG00000127666
ENSP00000248244.4
ENST00000248244.5
ENSMUSG00000047123
ENSMUSP00000055104.8
ENSMUST00000058136.8
ENST00000248244
ENSP00000248244
ENSMUSP00000055104
ENSMUST00000058136

MGI ID MGI:2147032
2147032

RGD ID 1590868

Unigene ID Hs.29344
Mm.203952

Homologene ID 8605

IPI ID IPI00170381
IPI00216715
IPI00398285