Protein IL1RAP

URN urn:agi-llid:3556
Total Entities 0
Connectivity 402
Name IL1RAP
Description interleukin 1 receptor accessory protein
Notes This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Osteoarthritis
Th17-Cell Differentiation
Bradykinin Effects in Inflammation
Toll-like Receptor Independent Sterile Inflammation
Mast-Cell Activation without Degranulation
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
IL1B Expression Targets -> Nociception
Lymphocyte Mediated Myocardial Injury in Myocarditis
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
beta-Cell Destruction through Cytokines in Diabetes Mellitus
CD4+T-Cell Response in Celiac Disease
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Th17-Cell Differentiation in Asthma
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Th17-Cell Numbers Reduction in HIV
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
HMGB1 and IL1B in Neuroinflammation
HMGB1 and IL1B in Neuronal Hyperexcitation
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cytokines Trigger Otitis Media
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
NF-kB Canonical Signaling
IL1B Expression Targets
IL1A Expression Targets
PPAR Psoriasis
Model of PPARG signaling in psoriasis
1_Inflammation in keratinocytes in the pathology of acne
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
2_The role of endothelial cells in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
drug-target moltransport
Differentiation of psoriatic T cells

MedScan ID 3556

LocusLink ID 3556
16180
25466

Alias interleukin IL1R3
6430709H04Rik
IL-1RACP
OTTHUMP00000209490
interleukin IL1 receptor accessory protein beta
interleukin IL-1RACP
OTTHUMP00000209488
OTTHUMP00000209486
interleukin IL1 receptor accessory protein
Il1racpb
interleukin-1 receptor 3
FLJ37788
MGC114349
interleukin IL-1R AcP
AI255955
AV239853
interleukin IL1 RAP
OTTHUMP00000209492
OTTHUMP00000209491
IL-1R AcP
interleukin-1 receptor accessory protein beta
IL-1 receptor accessory protein
OTTHUMP00000209487
C3orf13
RIKEN cDNA 6430709H04 gene
interleukin 1 receptor accessory protein
IL1 RAP
IL1R3
OTTHUMP00000209489
interleukin-33 receptot beta chain
interleukin-1 receptor accessory protein
IL-1R3
IL-1R-3

GO ID 0004908
0005149
0002114
0019221
0006955
0006954
0045087
0070498
0042094
0038172
0072602
0051092
0032736
0032754
2000778
0051965
0065003
0099151
1905606
0099560
0099545
0005576
0098978
0005887
0016020
0005886
1990782
0002376
1900006
0007165
0005737
0005615
0016021
0032991
0019966
0030674
0004871
0006461
0043234
0005622
0004888
0031224
0004872

KEGG ID rno:25466
hsa:3556
mmu:16180

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 16

OMIM ID 602626

Rat chromosome position 11q22

Hugo ID 5995
HGNC:5995

Human chromosome position 3q28

Swiss-Prot Accession A8K6K4
Q9NPH3
Q9NPH3.2
E9Q6I2
Q3V2X3
Q61730
Q3UEL3
Q61730.1
D1M8S3
Q63621
Q63621.1
B1NLD0
D3DNW0
O14915
Q86WJ7
Q3UVZ1
Q8VCB9
Q8N9C1
Q4V8K9
Q76LI3

PIR ID A57535

GenBank ID NC_000003
NR_157352
NR_157353
NM_001167931
NP_001161403
NM_001364879
NP_001351808
NM_001167928
NP_001161400
NM_001364881
NP_001351810
NM_002182
NP_002173
NM_001167929
NP_001161401
NM_001364880
NP_001351809
NM_134470
NP_608273
NM_001167930
NP_001161402
XM_017006348
XP_016861837
NG_029105
AC008249
AC108747
AF016261
AAC39609
AH009309
AAF71688
AAF71689
CH471052
EAW78100
EAW78101
EAW78102
EAW78103
AB006537
BAA25421
AF029213
AAB84059
AF167343
AAF71687
AF487335
AAO49451
AF538730
AAQ01755
AF538731
AAQ01756
AF538732
AAQ01757
AF538733
AAQ01758
AF538734
AAQ01759
AK095107
BAC04487
AK291669
BAF84358
BC016141
BC053621
AAH53621
BG032519
BM194193
BM760155
BM973472
DA024801
DN990628
EF591790
ABU90811
FJ998418
ACR82488
HY121126
Q9NPH3
NC_000082
XR_875736
XR_384528
NM_001159318
NP_001152790
NM_001159317
NP_001152789
NM_008364
NP_032390
NM_134103
NP_598864
NR_152416
AC154234
AC154601
CH466521
EDK97690
EDK97691
EDK97692
CT009561
AK032620
AK033972
AK034269
AK039582
BAC30392
AK045686
BAC32457
AK083209
BAE43382
AK136782
BAE23128
AK149467
BAE28898
BC021159
AAH21159
BU526001
X85999
CAA59991
Q61730
NC_005110
XR_001840406
XM_006248504
XP_006248566
NM_001167840
NP_001161312
NM_012968
NP_037100
AC_000079
AABR07072255
AAHX01070037
AAHX01070038
CH473999
EDL78120
AB079119
BAD15354
BC097339
AAH97339
GU123169
ACY68959
U48592
AAB03502
Q63621
XP_024309279
XM_017006347
XP_016861836
XM_024453511
AF167333
AF167334
XM_005247433
XP_005247490
XM_011512794
XP_011511096
XM_005247434
XP_005247491
NC_018914
AF167335
AF167336
AF167337
AF167338
AF167339
AF167340
AF167341
AF167342
AMYH02008408
AMYH02008409
HQ448120
ADQ32601
AC_000038
AAHY01126468
AAHY01126469
AAHY01126470
AC_000135
ABBA01058325
ABBA01058326
ABBA01058327
ABBA01058328
NT_005612
NW_001838884
NW_921807
AC_000046
CR591396
Q8N9C1
NT_039624
NW_001030584
Q3UEL3
Q3UVZ1
Q3V2X3
NW_047356
NW_001084663
Q4V8K9
Q76LI3

Swiss-Prot ID IL1AP_RAT
IL1AP_HUMAN
IL1AP_MOUSE
D1M8S3_RAT
A8K6K4_HUMAN
Q3UEL3_MOUSE
E9Q6I2_MOUSE
Q3V2X3_MOUSE
Q3UVZ1_MOUSE

Cell Localization Membrane
Cell membrane
Secreted
Plasma membrane

Ensembl ID ENSG00000196083
ENSP00000401132.1
ENST00000439062.6
ENSP00000072516.3
ENST00000072516.7
ENSP00000387371.1
ENST00000422940.5
ENSP00000314807.3
ENST00000317757.7
ENSP00000390541.1
ENST00000447382.6
ENSP00000409352.1
ENST00000422485.5
ENSMUSG00000022514
ENSMUSP00000128100.2
ENSMUST00000166294.8
ENSMUSP00000093843.2
ENSMUST00000096129.8
ENSMUSP00000023156.6
ENSMUST00000023156.12
ENSMUSP00000134202.1
ENSMUST00000174202.7
ENSRNOG00000001928
ENSRNOP00000051260.4
ENSRNOT00000043498.6
ENSRNOP00000002645.3
ENSRNOT00000002645.4
ENST00000447382.5
ENST00000439062.5
ENSP00000401132
ENST00000439062
ENSP00000072516
ENST00000072516
ENSP00000387371
ENST00000422940
ENSP00000314807
ENST00000317757
ENSP00000390541
ENST00000447382
ENSP00000409352
ENST00000422485
ENSP00000408893
ENST00000443369
ENSMUSP00000128100
ENSMUST00000166294
ENSMUSP00000093843
ENSMUST00000096129
ENSMUSP00000023156
ENSMUST00000023156
ENSMUSP00000134202
ENSMUST00000174202
ENSRNOP00000051260
ENSRNOT00000043498
ENSRNOP00000002645
ENSRNOT00000002645

MGI ID MGI:104975
104975

RGD ID 2893

Unigene ID Rn.10511
Hs.478673
Mm.253424

Homologene ID 1643

Shape Stick-vertex

IPI ID IPI00031789
IPI00107619
IPI00337687
IPI00925621
IPI00211004
IPI00113879
IPI00124823
IPI00563608
IPI00653610
IPI00929886
IPI00337688
IPI00167680