Protein CXCR3

URN urn:agi-llid:2833
Total Entities 0
Connectivity 5816
Name CXCR3
Description chemokine (C-X-C motif) receptor 3
Notes This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway CXC Chemokine Receptor Signaling
Proplatelet Maturation
Find me Signal: Apoptotic Cell Attracts Phagocyte
Neutrophil Recruitment and Priming
Neutrophil Chemotaxis
Natural Killer Cell Precursor -> Natural Killer Cell Surface Expression Markers
CD8+ Naive T-cell -> CD4+ Naive T-cell Surface Expression Markers
Proteins Involved in Atherosclerosis
Chemokines Signaling in Atherosclerosis
Proteins Involved in Myocarditis
Proteins Involved in Melanoma
Hashimoto's Thyroiditis
Enterocyte Mediated Mucosal Damage in Celiac Disease
Celiac Disease
Th1-Cell Activation in Crohn's Disease
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
B-Cell Chronic Lymphocytic Leukemia
Osteoclast Activation in Multiple Myeloma
Mast-Cell Related Chemokines Signaling in Asthma
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Multiple Sclerosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Glomerulonephritis
IL15 Expression Targets
CD Markers -> Expression Targets in Lymphoid System and Blood
Model of PPARG signaling in psoriasis
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
4_1_Polymorphisms associated with inflammatory bowel diseases
1_CD4+ T cell and epithelial cell response in celiac disease
drug-target pairs direct regulation

MedScan ID 2833

LocusLink ID 2833
12766
84475

Alias chemokine receptor CXCR3
chemokine (C-X-C) receptor III
IFN-inducible protein 10 receptor
IP-10/mig receptor
interferon-inducible protein 10 receptor
CD183 antigen
HuMig receptor
Mig-R
C-X-C chemokine receptor type 3
Mig receptor
CXCR3 receptors
CXCR3 receptor
C-X-C chemokine receptor type III
chemokine receptors CXCR3
GPR9
MigR
interferon-gamma-inducible protein-10 receptor
IFN-gamma-inducible protein 10 receptor
CKR-L2
CD183
CCR3_HUMAN
CMKAR3
IFNG-inducible protein 10 receptor
CXC-R3
IP-10/CXCL10 receptor
chemokine (C-X-C) receptor 3
RP23-49C8.4
CXCR3
CXCL10 receptor
G protein-coupled receptor 9
IP10 receptor
OTTHUMP00000070257
C-X-C motif chemokine receptor 3
IP-10/CXCL10 receptors
chemokine (C-X-C motif) receptor 3
IP10 receptors
Mig receptors
chemokine (C-X-C motif) receptor III
antigen CD183
chemokine receptor 3
IP10-Rs
OTTMUSP00000019734
IP10-R
CD182
IP-10 receptor
CXCR-3

GO ID 0019957
0016493
0016494
0019956
0004950
0007186
0010818
0001525
0006915
0019722
0007155
0060326
0007166
0070098
0006935
0006955
0006954
0007204
0030155
0002685
0005737
0009897
0005887
0005886
0019958
0004930
0038023
0007189
0071954
0016525
0001937
1900118
0045766
0008284
0050921
1900119
0051281
0045944
0007165
0009986
0016021
0016020
0004872
0006928
0030816
0043950
0005829
0004871
0005622
0019233

KEGG ID hsa:2833
mmu:12766
rno:84475

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position X 44.58 cM
X 41.0 cM

OMIM ID 300574

Rat chromosome position Xq22
Xq31

Hugo ID 4540
HGNC:4540

Human chromosome position Xq13.1
Xq13

Swiss-Prot Accession P49682
P49682.2
O88410
O88410.2
Q9JII9
Q9JII9.1
B2R982
O15185
Q7Z710
Q9P2T4
Q9P2T5
Q4V9Y6
Q9QWN6
A2ALY0

PIR ID JE0349

GenBank ID NC_000023
XM_017029436
XP_016884925
XM_005262257
XP_005262314
XM_005262256
XP_005262313
XM_017029435
XP_016884924
NM_001504
NP_001495
NM_001142797
NP_001136269
NG_029076
AB032735
BAA92297
AB032736
BAA92298
AB032737
BAA92299
AB032738
BAA92300
AL590763
CH471132
EAX05283
CQ834242
CAH05336
HI574346
CBX47662
U32674
AAC50505
Z79783
CAB02143
AF469635
AAP55851
AK313679
BAG36429
AY242128
AAO92295
BC034403
AAH34403
KU178101
ALQ33559
KU178102
ALQ33560
X95876
CAA65126
P49682
NC_000086
NM_009910
NP_034040
AL805980
CH466564
EDL14135
AB003174
BAA34045
AF045146
AAC40163
BC096626
AAH96626
O88410
NC_005120
NM_053415
NP_445867
AC_000089
AABR07039203
AAHX01111638
CH473966
EDL95884
AF223642
AAF76982
BC091136
AAH91136
Q9JII9
NC_018934
AMYH02039677
DQ892460
ABM83386
DQ895673
ABM86599
AC_000042
AAHY01215118
AC_000155
ABBA01067767
ABBA01067768
CAM25746
NT_011669
NW_001842373
NW_927711
AC_000066
NT_039706
NW_001035176
NW_001091918
NW_048043

Swiss-Prot ID CXCR3_HUMAN
CXCR3_MOUSE
CXCR3_RAT
A2ALY0_MOUSE

Cell Localization Cell membrane
Plasma membrane

Ensembl ID ENSG00000186810
ENSP00000362795.4
ENST00000373691.4
ENSP00000362797.3
ENST00000373693.4
ENSMUSG00000050232
ENSMUSP00000052444.6
ENSMUST00000056614.6
ENSRNOG00000003305
ENSRNOP00000004406.3
ENSRNOT00000004406.5
ENSP00000362795
ENST00000373691
ENSP00000362797
ENST00000373693
ENSMUSP00000052444
ENSMUST00000056614
ENSRNOP00000004406
ENSRNOT00000004406

MGI ID MGI:1277207
1277207

RGD ID 621528

Unigene ID Hs.198252
Mm.12876
Rn.24787

Homologene ID 1153

Shape Stick-vertex

IPI ID IPI00027754
IPI00640020
IPI00651732
IPI00200582
IPI00314938