Pathway
|
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
|
|
T-Cell Dependent B-Cell Activation
|
|
V(D)J Recombination Activation
|
|
Immunoglobulin Class-Switch Recombination Activation
|
|
Immunoglobulin Genes Transcriptional Activation
|
|
T-Cell Maturation (Hypothesis)
|
|
Natural Killer Cell Activation
|
|
CD8+ T-Cell Activation
|
|
T-Cell Cytotoxic Mediated Cell Death
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
AHR Signaling in Treg and Dendritic Cells Function
|
|
AHR Signaling in Th17 Cells Function
|
|
Th17-Cell Differentiation
|
|
AHR Signaling in Tr1 Cells Function
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Plasmin Effects in Inflammation
|
|
Proplatelet Maturation
|
|
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Mast-Cell Activation without Degranulation through CXCR4 Signaling
|
|
Mast-Cell Activation without Degranulation
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
Macrophage M1 Lineage
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
AHR Signaling in M1 Macrophages Function
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
|
|
Neutrophil Recruitment and Priming
|
|
Negative Acute Phase Proteins Synthesis
|
|
Positive Acute Phase Proteins Synthesis
|
|
Vascular Endothelial Cell Activation by Cytokines
|
|
Adipokines Production by Adipocyte
|
|
Nociception Expression Targets Signaling
|
|
CCR1 Expression Targets
|
|
IL6 Expression Targets -> Nociception
|
|
Proteins Involved in Atherosclerosis
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
|
|
Preconditioning Ischemia
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
SOCS in Negative Feedback Regulation in Myocarditis
|
|
Hair Follicle Keratinocyte Apoptosis
|
|
Acute Phase in Atopic Dermatitis
|
|
Atopic Dermatitis
|
|
Melanoma
|
|
Apoptosis Block in Melanoma Cell
|
|
T-Cells Differentiation Block in Psoriasis
|
|
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
|
|
IL22 Induces Keratinocyte Proliferation in Psoriasis
|
|
Dendritic Cell Activation in Systemic Lupus Erythematosis
|
|
Th17-Cell Function in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Oxidative Stress in Vitiligo
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Toll-like Receptors in beta-Cell
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Donohue Syndrome Progression (Hypothesis)
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Proteins Involved in Diabetic Nephropathy
|
|
Proliferative Diabetic Retinopathy
|
|
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
|
|
Proteins Involved in Insulin Resistance
|
|
Adiponectin Synthesis Declines in Insulin Resistance
|
|
Insulin Resistance in Hepatocytes
|
|
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Destruction in Diabetes Mellitus Type 1
|
|
Hashimoto's Thyroiditis
|
|
Thyroid Hormones in Adipose Tissue Metabolism
|
|
Thyroid Dysfunction
|
|
Graves Ophthalmopathy
|
|
Immune System Activation in Hyperthyroidism
|
|
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
|
|
Overt Hypothyroidism, Primary
|
|
Thyrotropin Releasing Hormone (TRH) Hypothalamic Release in non-Autoimmune Hypothyroidism
|
|
Central Hypothyroidism
|
|
Tertiary Hypothyroidism
|
|
Adipokines Production by Adipocyte Impaired in Obesity
|
|
CD4+T-Cell Response in Celiac Disease
|
|
CD8+ T-Cell Response in Celiac Disease
|
|
Metastatic Colorectal Cancer
|
|
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
FLT3/KIT/MLL Signaling in Leukemia
|
|
Apoptosis Block in Acute Myeloid Leukemia Cell
|
|
RARA Signaling in Acute Myeloid Leukemia (M3)
|
|
Acute Myeloid Leukemia
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Diffuse Large-B-Cell Lymphoma ABC Subtype
|
|
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
|
|
Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
Hodgkin and Reed-Sternberg Cells Reprogramming
|
|
Mantle Cell Lymphoma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Pancreatic Ductal Carcinoma
|
|
Growth Factor Signaling in Pancreatic Neoplasms
|
|
TRPM7/8 in Pancreatic Adenocarcinoma
|
|
Eosinophil Survival in Asthma
|
|
TSLP Signaling in Bronchial Epithelial Cell in Asthma
|
|
Periostin (POSTN) Production by Airway Epithelium in Asthma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
Goblet-Cell Exocytosis in Asthma
|
|
Goblet-Cell Related Mucus Secretion in Asthma
|
|
Club-Cell Role in Asthma
|
|
Basophil Activation in Asthma
|
|
B-Cell Mediated IgE Production in Asthma
|
|
Th17-Cell Differentiation in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
Osteoclast Activation in Gout
|
|
Neutrophil Recruitment in Sinovium in Gout
|
|
Dendritic Cell Dysfunction in Psoriatic Arthritis
|
|
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
|
|
Osteoclast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
CCR5 Signaling in Macrophages
|
|
Th17-Cell Numbers Reduction in HIV
|
|
CD4+ T-Cell Function Decline in HIV
|
|
CD4+ T-Cell Death in HIV
|
|
Diabetes Induced Periodontitis
|
|
Cowden Syndrome
|
|
Gluten Impact on Neuronal System (Hypothesis)
|
|
Bone Loss in Osteoporosis
|
|
BDNF Upregulation Triggered by Seizures
|
|
Glioma Invasion Signaling
|
|
Glioma Stem Cell Program Activation
|
|
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Breast Cancer
|
|
ESR1 Signaling in Breast Cancer
|
|
Endometrial Cancer
|
|
Endometrioid Endometrial Cancer
|
|
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
|
|
Endometrioid Ovarian Carcinoma
|
|
Clear Cell Ovarian Carcinoma
|
|
High-Grade Serous Ovarian Carcinoma
|
|
Low-Grade Serous Ovarian Carcinoma
|
|
Ovarian Cancer
|
|
Mucinous Ovarian Carcinoma
|
|
IL6/JAK/STAT3 Signaling in Cholesteatoma
|
|
Cholesteatoma
|
|
Prostate Cancer
|
|
IL10/STAT3 Signaling in M2 Macrophage and Retinal Angiogenesis
|
|
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
|
|
Cytokines Trigger Otitis Media
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Endothelial Cell Dysfunction in Pyelonephritis
|
|
IFNG -> ARRB1/STAT1 Signaling
|
|
CLCF1 Expression Targets
|
|
CTF1 Expression Targets
|
|
CXCL12 Expression Targets
|
|
CCL3 Expression Targets
|
|
CCL3L1 Expression Target
|
|
CCL16 Expression Targets
|
|
CCL5 Expression Targets
|
|
CCL7 Expression Target
|
|
CCL7 Expression Targets
|
|
CCL8 Expression Targets
|
|
CCL2 Expression Targets
|
|
CSF3 Expression Targets
|
|
CSF2 -> STAT Expression Targets
|
|
LIF Expression Targets
|
|
CNTF Expression Targets
|
|
Clozapine Induced Granulocytopenia
|
|
GH2/GHR Expression Target
|
|
GH1/GHR -> STAT Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
Receptors and Adaptor Proteins Activated in Cancer
|
|
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
|
|
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
|
|
IL23A and IL17A Provoke Cancer-Associated Inflammation
|
|
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
|
|
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
|
|
IL13/STAT6/ZEB1 Signalling Promotes Cancer Metastatic Progression
|
|
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
|
|
VEGFA Dependent Angiogenesis in Cancer
|
|
Epithelial to Mesenchymal Transition in Cancer: Overview
|
|
Cancer Cells Inhibit Adipocyte Differentiation
|
|
Skeletal Muscle Wasting in Cancer Cachexia
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
Myeloid Derived Suppressor Cells in Cancer Immune Escape
|
|
IDO1 in Cancer Immune Escape
|
|
IGF2 -> STAT Expression Targets
|
|
IGF1 -> STAT Expression Targets
|
|
Insulin -> STAT Expression Targets
|
|
IGF1R -> STAT Signaling
|
|
IFNLR1-> STAT/NFKB Signaling
|
|
IFNW1/IFNR Expression Target
|
|
IFNA1/IFNR Expression Targets
|
|
IFNB1/IFNR Expression Targets
|
|
IFNG/IFNR Expression Targets
|
|
IL22R -> STAT3 Signaling
|
|
IL13R -> STAT6 Signaling
|
|
IL31R -> STAT Signaling
|
|
IL15R -> STAT Signaling
|
|
IL7R -> FOXO/NF-kB Signaling
|
|
IL15R -> NF-kB/NFATC Signaling
|
|
IL2R -> ELK/SRF/MYC Signaling
|
|
IL10R -> STAT Signaling
|
|
IL13R -> STAT Signaling
|
|
IL3R -> STAT Signaling
|
|
IL27R -> STAT Signaling
|
|
IL7R -> STAT Signaling
|
|
IL9R -> STAT Signaling
|
|
IL5R -> STAT Signaling
|
|
IL11R -> STAT3 Signaling
|
|
IL6R -> STAT Signaling
|
|
IL2R -> STAT Signaling
|
|
IL6ST -> STAT5B Signaling
|
|
IL4R -> STAT Signaling
|
|
IL23R -> STAT3/NF-kB Signaling
|
|
IL21R -> STAT Signaling
|
|
IL4R -> ELK/SRF/HMGY Signaling
|
|
IL7 Expression Targets
|
|
IL13 Expression Targets
|
|
IL21 Expression Targets
|
|
IL15 Expression Targets
|
|
IL3 Expression Targets
|
|
IL6 Expression Targets
|
|
IL10 Expression Targets
|
|
IL5 Expression Targets
|
|
IL22 Expression Targets
|
|
IL11 Expression Targets
|
|
IL9 Expression Targets
|
|
IL31 Expression Targets
|
|
IL4 Expression Targets
|
|
IL2 Expression Targets
|
|
UrokinaseR -> ELK/SRF Signaling
|
|
UrokinaseR -> STAT Signaling
|
|
PTPRC -> STAT6 Expression Targets
|
|
OSM/OSMR Expression Targets
|
|
OSM/IL6ST/LIFR Expression Targets
|
|
PRL/GHR -> STAT Expression Targets
|
|
PTPRC -> STAT6 Signaling
|
|
FOXO1 Signaling
|
|
Ras-GAP Regulation Signaling
|
|
LTA Expression Targets
|
|
TNF -> STAT Expression Targets
|
|
TNFRSF1A -> STAT Signaling
|
|
B-Cell Differentiation Inhibition by Dioxin
|
|
PLAU -> STAT1 Expression Targets
|
|
PLAU -> ELK-SRF/AP-1 Expression Targets
|
|
PPAR Psoriasis
|
|
pprarg neg, uknown targets, ps-positive
|
|
Model of PPARG signaling in psoriasis
|
|
New Pathway (3)
|
|
dsRNA induces innate immunity and INFs in alveolar cells
|
|
IFN signaling in alveolar cells
|
|
Dendritic Cell Activation in COVID19
|
|
2_Acute phase initiation in atopic dermatitis
|
|
1_Differentiation of psoriatic T cells
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
2_The role of endothelial cells in pyelonephritis
|
|
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
|
|
2_Cardiomyocyte hypertrophy
|
|
3_2_Regulation of airway surface liquid (ASL) thickness
|
|
3_1_Mucus accumulation in asthma
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
|
|
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
|
|
2_CD8+ T-cell response and mucosal damage in celiac disease
|
|
5_Tax-mediated dysregulation of NF-kB signaling in HTLV-1 infection
|
|
1_Inflammatory mediators increase the production of hepcidin (HAMP)
|
|
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
|
|
4_2_Insulin resistance: inflammation-related insulin resistance
|
|
4_3_Insulin resistance: FFA-related insulin resistance
|
|
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
|
|
3_Islet beta-cell destruction in T1D
|
|
2_Defective tolerance of autoreactive T-cell in T1D
|
|
1_Decreased secretion of thyroid hormones
|
|
Differentiation of psoriatic T cells
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|