Protein GAB1

URN urn:agi-llid:2549
Total Entities 0
Connectivity 945
Name GAB1
Description GRB2 associated binding protein 1
Notes The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Pathway Prolactin Production
Nociception Expression Targets Signaling
NTSR1 Expression Targets
DRD2 Expression Targets
DRD2 -> TRPC1 Transcription
NTRK1/2/3 -> Acetylcholine Production
Endothelial Cell Dysfunction in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
IL22 Induces Keratinocyte Proliferation in Psoriasis
Insulin Resistance in Hepatocytes
Prolactinoma Overiew
Hodgkin Lymphoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
IL6 Promotes Inflammation in Muscular Dystrophies
Medulloblastoma
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Ovarian Cancer
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Steroids Induced Cataract
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Cytokines Trigger Otitis Media
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
AREG -> FOXO3A Expression Target
Dopamine/Gi Expression Targets
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
Tamoxifen Induced Endometrial Cancer
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> FOXO3A Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> FOXO3A Expression Target
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
VEGF Independent Angiogenesis in Cancer
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
LPA Expression Targets
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> FOXO3A Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
NTS Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
NTRK -> FOXO/MYCN Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
FOXO1 Signaling
PI3K/RAC1 Signaling
ERK5/MAPK7 Signaling
ERK/MAPK Canonical Signaling
TGFA -> FOXO3A Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
2_Interleukin-17 and interleukin-22 signaling in psoriasis
3_Mesangial cell dysfunction in glomerulonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations in GWA Studies of Asthma

MedScan ID 2549

LocusLink ID 2549
14388
361388

Alias Gab1
GRB2-associated binder 1
growth factor receptor bound protein 2-associated protein 1
GRB2-associated binding protein 1
GRB2-associated binding protein 1 long isoform
AA408973
growth factor receptor bound protein 2-associated protein I
AW107238
GRB2-associated binding protein I
Gab I
DFNB26
GRB2-associated-binding protein 1

GO ID 0005070
0038128
0031532
0001525
0007411
0090668
0007173
0008286
0045766
0038089
0014068
0051897
0035728
0038084
0005911
0005829
0007257
0000187
0035924
0008544
0007507
0070102
0060711
0048008
0043410
0030334
0006979
0007165
0005737
0016303
0046934
0004871
0008283
0046854
0036092
0048015
0014066
0038095
0008543
0045087
0048011

KEGG ID hsa:2549
mmu:14388

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 8

OMIM ID 604439
605428

Rat chromosome position 19q11

Hugo ID 4066
HGNC:4066

Human chromosome position 4q31.21

Swiss-Prot Accession Q13480
Q9HA84
Q13480.2
A0A1B0GS41
Q505A4
Q9QYY0
Q9QYY0.2
A8K152
Q4W5G2
Q6P1W2
Q91VW7

PIR ID S68442

GenBank ID NC_000004
NM_207123
NP_997006
NM_002039
NP_002030
XM_017007969
XP_016863458
XM_017007970
XP_016863459
XM_017007971
XP_016863460
XM_006714168
XP_006714231
XM_006714167
XP_006714230
XM_017007966
XP_016863455
XM_017007968
XP_016863457
XM_017007967
XP_016863456
AC097658
AC104685
AAY40964
CH471056
EAX05072
EAX05073
DQ021880
AAY26398
JA780910
CCH22599
JA780912
CCH22600
AK022142
BAB13970
AK074381
BAB85065
AK289767
BAF82456
AK295684
BAH12155
AK314635
AL049449
BC030115
BC030751
BC064848
AAH64848
DA109618
DA249555
U43885
AAC50380
Q13480
NC_000074
NM_001301298
NP_001288227
XM_006530677
XP_006530740
XM_006530676
XP_006530739
XM_017312576
XP_017168065
XM_011248309
XP_011246611
XM_011248310
XP_011246612
XM_006530674
XP_006530737
XM_017312575
XP_017168064
NM_021356
NP_067331
AC116800
AC132606
CH466525
EDL10884
EDL10885
HM571518
HM571519
HM571520
HM571521
HM571522
HM571523
HM571524
HM571525
HM571526
HM571527
HM571528
HM571529
HM571530
HM571531
HM571532
HM571533
AJ250669
CAB59832
AK045352
AK050935
AK132176
AK155423
BC007483
AAH07483
BC094659
AAH94659
BX523462
CT010264
CAJ18472
Q9QYY0
NC_005118
NM_001108444
NP_001101914
AC_000087
AABR07043601
AAHX01097889
AAHX01097890
AAHX01097891
AAHX01097892
AAHX01097893
AAHX01097894
CH473972
EDL92297
EDL92298
GQ140625
ACS34829
XM_005262881
XP_005262938
XM_005262882
XP_005262939
NC_018915
AMYH02010234
AMYH02010235
XM_011248308
XP_011246610
AC_000030
AAHY01072438
AAHY01072439
AAHY01072440
AAHY01072441
AAHY01072442
AAHY01072443
AAHY01072444
AAHY01072445
AAHY01072446
AC_000136
ABBA01070001
ABBA01070002
ABBA01070003
XM_006530675
XP_006530738

Swiss-Prot ID GAB1_HUMAN
GAB1_MOUSE

Ensembl ID ENSG00000109458
ENSP00000262994.4
ENST00000262994.8
ENSP00000262995.4
ENST00000262995.8
ENSP00000424554.1
ENST00000505913.5
ENSMUSG00000031714
ENSMUSP00000147784.1
ENSMUST00000210676.1
ENSMUSP00000034150.8
ENSMUST00000034150.9
ENSRNOG00000017879
ENSRNOP00000024390.3
ENSRNOT00000024390.5
ENSP00000262994
ENST00000262994
ENSP00000262995
ENST00000262995
ENSP00000424554
ENST00000505913
ENSMUSP00000034150
ENSMUST00000034150
ENSRNOP00000024390
ENSRNOT00000024390

MGI ID MGI:108088

RGD ID 1311085

Unigene ID Hs.80720
Hs.618456
Mm.277409
Rn.1725

Homologene ID 1542