Protein CCL2

URN urn:agi-llid:6347
Total Entities 0
Connectivity 11154
Name CCL2
Description chemokine (C-C motif) ligand 2
Notes This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Proplatelet Maturation
Toll-like Receptor Independent Sterile Inflammation
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
CCR1 Expression Targets
IL1B Expression Targets -> Nociception
Proteins Involved in Atherosclerosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Low-Density Lipoproteins and Chemokines in Atherosclerosis
Chemokines Signaling in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Arterial Hypertension
Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
IL17 Signaling in Psoriasis
Proteins Involved in Systemic Lupus Erythematosus
Toll-like Receptors in beta-Cell
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proteins Involved in Insulin Resistance
Adipose Tissue Inflammation Provokes Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
Fatty Acids in Hypertension and Atherosclerosis Development
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Proteins Involved in Inflammatory Bowel Diseases
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Eosinophil Survival in Asthma
Mast-Cell Activation in Asthma
Neutrophil Recruitment in Sinovium in Gout
Proteins Involved in Polycystic Ovary Syndrome
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
Proteins with Altered Expression in Systemic Scleroderma
Proteins Involved in HIV Type 1 Infection
CCR5 Signaling in Macrophages
Estrogen Effects on Pregnancy Gingivitis
Majeed Syndrome
NF-kB Signaling Activation in Huntington Disease
Proteins Involved in Alzheimer's Disease
Proteins Involved in Epilepsy
Blood-Brain Barrier Disruption in Epileptiform Disorders
HMGB1 and IL1B in Neuroinflammation
ADK Expression Downregulation after Acute Seizures
Proteins Involved in Glioma
CCL2 Role in CGRP Expression and Release
Proteins with Altered Expression in Migraine
Proteins Involved in Neuroblastoma
Proteins Involved in Amyotrophic Lateral Sclerosis
Neuroinflammation in Amyotrophic Lateral Sclerosis
Proteins Involved in Multiple Sclerosis
Proteins Involved in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Proteins Involved in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
Proteins Involved in Glaucoma
Cochlear Inflammation (Noise-Induced)
Cytokines Trigger Otitis Media
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Polycystic Kidney Disease
Proteins Involved in Glomerulonephritis
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
S100B Expression Targets
Noradrenaline/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Serotonin/Gq Expression Targets
BMP7/BMPR2/ACVR2 Expression Targets
Elevated Receptors -> Expression Targets in Adipose Tissue
GPCR Family -> Expression Targets in Adipose Tissue
CTF1 Expression Targets
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Myocardium
Elevated Receptors -> Expression Targets in Blood Vessel
CXCL2 Expression Targets
CXCL5 Expression Targets
CCL3 Expression Targets
CCL16 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
Cyclosporine Induced Nephrotoxicity
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> STAT Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
Glutamate/Gq Expression Targets
Elevated Receptors -> Expression Targets in Liver
Elevated Receptors -> Expression Targets in Mouth
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
HIF1A as Master Regulator of Angiogenesis in Cancer
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
INHBA/ACVR2/BMPR Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
Fibrinogen Expression Targets
Elevated Receptors -> Expression Targets in Skin
IFNG/IFNR Expression Targets
IL13 Expression Targets
IL6 Expression Targets
IL2 Expression Targets
PTPRC -> BCL6 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Receptor Tyrosine Kinase Family -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Blood
CD40 -> Expression Targets in Thymus
P2RX7 -> Expression Targets in Nerve Tissue
Elevated Receptors -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
Adenosine Expression Targets
OSM/OSMR Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
NTS Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
CSF1 -> STAT Expression Targets
MDK/PTN Expression Targets
Collagen -> NF-kB Expression Targets
PAF Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
TGFB2-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR7 Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
ROS in Triggering Vascular Inflammation
Elevated Receptors -> Expression Targets in Kidney
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFA -> STAT Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
pathway 3
e
pathway 4
New Pathway (2)
cypa
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of muscle mass
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of breast cancer risk
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of recurrence rate
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of muscle mass
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of breast cancer risk
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of recurrence rate
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of aortic smooth muscle cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of peripheral lymphocyte
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of lymph node
Neighbors of colon
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of alveolus
Neighbors of coronary artery
Neighbors of uterine cervix
Neighbors of omentum
Neighbors of vein
Neighbors of arteriole
Neighbors of bronchus
Neighbors of nose
Neighbors of cornea
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of lymph node of mesentery
Neighbors of vagina
Neighbors of vitreous body
Neighbors of cerebral cortex
Neighbors of brain blood vessel
Neighbors of bladder
Neighbors of nervous system
Neighbors of retina blood vessel
Neighbors of cervical lymph node group
Neighbors of periodontal ligament
Neighbors of corpus luteum of ovary
Neighbors of nerve
Neighbors of globus pallidus
Neighbors of amniotic cavity
Neighbors of knee joint
Neighbors of lymphatic vessels
Neighbors of reproductive system
Neighbors of pleura
Neighbors of choroid plexus
Neighbors of hair follicle
Neighbors of artery wall
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of heat shock protein 90
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of endothelin
Neighbors of NOS
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of alpha2 adrenoceptor
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of gonadotropins
Neighbors of immunoglobulin
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of endostatins
Neighbors of relaxin
Neighbors of TORC1
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of adrenoceptor
Neighbors of phosphodiesterase
Neighbors of caspase
Neighbors of phosphoinositide phospholipase C
Neighbors of deacetylase
Neighbors of TLR4/Myd88
Neighbors of TNF-alpha receptor
comon ps_pos, pprarg_neg targets
IFN signaling in alveolar cells
Overview. Diseases of circulatory system (chapter 8)
Overview. Diseases of the nervous system (chapter 5)
Overview. Diseases of the genitourinary system (chapter 13)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_Low-density lipoprotein internalization and the accumulation of lipids in atherosclerosis
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_1_Polymorphisms associated with inflammatory bowel diseases
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
1_Microangiopathy in diabetic neuropathy
drug-target pairs direct regulation
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Atherosclerosis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Crohn's Disease
Genes with Mutations Associated with Systemic Scleroderma

Source curated
GO component

MedScan ID 6347
658850

LocusLink ID 6347
20293
287562
24770
103680
20296
793193
281043
282062

Alias C-C motif chemokine 12-like
HSMCR30
Ccl12
Monocyte chemoattractant protein-1
chemokine (C-C motif) ligand 12
Small inducible cytokine A2
SY02_HUMAN
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
MGC9434
Monocyte chemotactic protein I
small inducible cytokine A2 (monocyte chemotactic protein 1)
monocyte chemotactic and activating factor
chemokine (C-C motif) ligand 2
C-C motif chemokine ligand 2
monocyte chemo-attractant protein-1
chemokine (C-C motif) ligand II
GDCF II
Monocyte chemoattractant protein MCP-1
small inducible cytokine A12
LOC100504977
Ccl-2
Monocyte secretory protein JE
MCP-I
MCP-1/MCAF
MCP-1-related chemokine
CCL2
SMC-CF
monocyte chemotactic protein 5
small inducible cytokine subfamily A (Cys-Cys), member II
MCAF/MCP-1
monocyte chemoattractant protein 5
OTTMUSP00000000792
MCP-1
GDCF-2
monocyte chemotactic protein 1, homologous to Sig-je
small inducible cytokine subfamily A (Cys-Cys), member 2
SY02
SCYA2
MCP-5
Monocyte chemotactic protein 1
C-C motif chemokine 2
C-C motif chemokine 12
GDCF-2 HC11
Scya12
monocyte chemotactic protein 1, homologous to mouse Sig-je
GDCF IIs
LOC100048556
Monocyte chemoattractant protein I
HC11
MCAF
MCP1
small-inducible cytokine A2
small-inducible cytokine A12
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to
AI323594
monocyte chemoattractant protein 1
Small inducible cytokine A2 (monocyte chemotactic protein, homologous to mo
monocyte chemotactic protein
Sigje
Ccl12_predicted
Monocyte chemotactic and activating factor
HC 11
monocyte chemotactic protein 1, homologous to Sig-je
HC11 protein
HC(11)
HC-11
expressed sequence AI323594
chemokine (C-C motif) ligand 12 (predicted)
LOC793193
chromosome
hypothetical protein LOC793193
scaffold
rp23-350g1.3
small inducible gene je
homologous to mouse sig-je

GO ID 0048020
0031727
0008009
0004672
0005102
0007186
0007187
0007259
0000165
0036499
0001525
0009887
0043615
0007155
0007166
0019725
0044344
0071346
0071347
0071222
0071407
0071356
0070098
0006935
0019221
0007010
0048245
0035684
0006959
0006954
0031663
0048247
0048246
0002548
2000134
0034351
2000502
0043524
1905563
0030593
0070374
0043547
1904783
0050870
2000427
0090280
2000353
0051770
0051968
0043491
0006468
0008360
0009617
0019233
0007165
0019079
0005623
0005576
0005615
0005125
0006955
0070664
0002687
0016004
0061844
0006816
0007267
0006874
0006887
0031640
0044828
0010469
0005622
0048471
0032967
0030425
0036006
0036120
0042493
0043066
0001666
0030139
0031100
0071403
0016525
0002523
0010759
0002693
0009408
0048010
0043085
0051384
0071549
0090314
0050729
0044299
0005737
0071300
0001938
0060137
0008201
0060135
0007568
0006916
0032760
0010574
0010332
0045202
0043025
0014823
0090026
0071318
0043679
0001912
0090265
0005791
0007179
0032869
0030968
0033552
0071354
0035690
0050806
0043200
0046677
0043204
0006987
0045471
0032570
0044267
0009612
0009611
0004871
0043277
0001664
0032496
0016020
0009618
0005515
0007600
0042466

KEGG ID hsa:6347
mmu:20293
mmu:105242482
rno:287562

MedLine Reference 10331005
11751160
12029068
12071442
12080327
12133987
12135683
12196270
12370537
12372783
12377739
12390882
12409843
12540575
12540607
12761250
12870648
12899200
12950323
14505427
14638441
14684844
14693680
14967845
14978197
15178559
15183841
15205118
15240134
15308783
15504940
15627719
15742444
15829559
15880558
15917991
15930146
15978006
16102724
16116069
16127145
16132691
16164699
16174730
16196033
16265704
16282363
16697654
16799229
16886721
1704226
10079097
10349636
10395330
10397169
10438970
10570305
10746730
10790402
10995569
11042159
11076861
11130978
11217851
11257138
11485904
11714821
11716961
11735217
11756151
11756344
11918087
11937571
11971015
12011011
12080938
12085314
12098066
12106688
12126650
12131093
12151080
12165826
12355436
12388376
12466851
12477932
12525571
12594253
12623845
12682245
12707348
12734374
12756299
12847259
12850812
12925209
13129912
1347470
1406651
1448065
14500652
14516793
14520519
14527928
14532907
14550294
14576355
14615370
14633605
14635040
14662884
14670305
14679181
14688348
14709405
14739122
15019295
15020650
15033992
15063799
15075201
15081318
15095371
15153515
15163738
15210789
15240672
15358037
15377395
15381731
15518805
15528472
15539456
15579457
15579460
15597153
15611273
15661915
15705791
15712606
15718500
15748167
15774854
15829914
15855647
15886005
15928200
16014038
16105698
16115031
16129712
16141072
16141073
16166627
16166738
16177325
16239969
16243300
16278381
16299331
16337133
16339568
16339576
16397233
16443645
16462739
16678847
16691201
16691291
16728728
16809344
16825596
16882009
16888027
16960104
16982835
16990567
16997857
17047515
17074847
17112893
17142777
1794049
1969921
2004761
2065676
2071154
2513477
2576529
2910858
3108379
3287374
6872001
7528168
7579889
7590247
7594550
7601457
7622488
7642742
7650394
7717454
7737353
7767000
7789623
7836768
7945333
7947467
7954525
8051420
8132324
8144933
8216854
8268655
8342023
8423056
8449498
8455595
8631787
8661152
8662231
8683100
8757628
8759763
8827514
8835527
8920881
8981365
8996246
9098403
9177770
9192769
9196007
9321482
9365109
9366570
9405660
9463410
9480983
9653646
9734366
9779377
9786242
9990422
10068657
10198043
10453044
10477718
10529171
10542238
10623817
10644332
10706668
10734104
10751368
10770925
10942204
10982368
10985244
11083865
11145723
11154208
11750041
11751881
11776402
11912219
11989790
11999660
12009356
12022754
12067898
12078856
12082252
12093796
12117737
12127997
12149192
12183528
12186702
12195705
12204371
12234797
12239249
12351486
12372466
12374865
12391099
12391196
12393171
12397639
12399623
12408680
12410798
12413001
12419245
12443832
12460032
12470469
12473373
12485413
12488502
12505750
12520153
12520365
12540965
12632067
12665582
12724308
12753088
12758167
12787135
12805068
12826189
12826377
12846738
12946945
12957789
12960255
13679391
14517168
14517792
14550782
14576080
14597108
14602575
14620921
14660607
14687706
14733721
15016614
15022320
15034225
15041705
15077296
15082170
15110609
15123743
15167690
15188361
15191525
15191888
15191916
15203564
15226634
15257681
15280531
15312962
15349727
15389752
15466648
15492853
15529362
15545821
15599324
15602730
15611878
15654958
15677312
15722361
15745922
15780578
15832427
15866653
15880317
15883814
15900302
15919935
15976326
15979992
16003740
16004967
16009177
16009638
16020745
16095529
16105652
16129702
16195477
16204411
16206198
16213182
16214031
16230097
16249002
16280328
16280979
16307829
16309586
16318581
16351713
16352737
16358960
16359995
16362156
16415174
16427785
16436595
16439461
16445900
16474202
16479072
16504689
16516290
16518346
16597919
16609683
1661560
16631114
16636247
16636603
16672419
16697212
16705739
16712788
16730843
16733654
16751386
16781696
16795034
16802342
16825597
16828028
16867220
16873204
16939660
16980310
16997300
17052731
17082648
17098977
17187019
17202846
2357211
2465924
2501656
2518726
2923622
7651403
8051410
8107690
8195247
8639605
8989326
9287323
9364936
9405404
9501225
9548499
9558113
9670957
9789057
9792375
9973507
10587439
10918580
15489334
16814297
16835702
17008880
17032917
17065190
17091019
17138827
17169533
17218539
17262819
17280738
17283105
17284607
17307163
17322498
17364892
17379849
17384985
17390372
17395051
17404035
17407231
17424890
17458901
17465499
17485071
17495598
17522215
17525255
17530707
17596666
1857712
2322286
2648385
8627182
8898111
9792674
9837883
11980865
14662900
16543609
16873893
17003237
17088347
17125873
17126305
17135576
17160673
17220320
17258864
17283277
17307812
17329566
17347584
17364026
17371458
17409491
17433708
17452470
17456776
17473219
17507908
17549399
17575105
17589343
17640882
17652758
17662241
17710158
9884336
16758320
16968890
17164575
17180354
17191078
17303665
17460389
17530714
17581219
17632282
2106664
1543494
15659710
1721821
8060303

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Bos taurus

Mouse chromosome position 11 49.9 cM
11 47.0 cM

OMIM ID 158105
609423
607948
182940

Rat chromosome position 10q26

Hugo ID 10618
HGNC:10618

Human chromosome position 17q12
17q11.2-q12

Swiss-Prot Accession P13500
P13500.1
Q545B5
Q62401
Q62401.1
D4ABS1
B2R4V3
Q9UDF3
Q9QYD6
Q6UZ82
Q5SVB4
Q545B5_MOUSE
CCL12_MOUSE
CCL2_HUMAN
B2R4V3_HUMAN

PIR ID A35474

GenBank ID NC_000017
NM_002982
NP_002973
NG_012123
AC005549
AF519531
AAM54046
AH001509
AAA36330
AH002970
AAA60308
AY357296
AAQ75526
CH471147
EAW80211
EAW80212
D26087
BAA05080
M37719
AAA18102
X60001
Y18933
CAC14049
AK311960
BAG34900
AV733621
BC009716
AAH09716
BG530064
BT007329
AAP35993
M24545
AAA18164
M26683
AAA96708
M28226
AAA60309
S69738
AAB29926
S71513
AAB20651
X14768
CAA32876
P13500
NC_000077
NM_011331
NP_035461
AL645596
DS033261
EDL01207
DS033265
EDL01219
AF065934
AAF15384
AF065935
AAF15385
AF065936
AAF15386
AF065937
AAF15387
AF065938
AAF15388
AK012356
BAB28185
BC027520
AAH27520
U50712
AAB50053
U66670
AAB49424
Q62401
NC_005109
NM_001105822
NP_001099292
AC_000078
AAHX01065149
AC114440
CH473948
EDM05440
ABM84651
ABW03626
EU176175
AAHY01094593
AAHY01094594
AC_000149
CAI25041
AC_000033
DQ893725
AMYH02033336
AABR06064880
ABBA01011212
NC_018928
M31625
M31626
M30816
M28225
M28224
M28223
NT_010799
NW_001838432
NW_926772
AC_000060
Q6UZ82
NT_096135
NW_001030484
NW_001084656
NW_047336
NW_001030485
XM_001480891
XP_001480941
XM_001480892
XP_001480942
XM_001480893
XP_001480943
XM_001081016
XP_213425
XM_213425
XP_001081016
Q5SVB4
BAE29972
J04467
CAA34901
BAE30690
AF065929
BAE21250
BAE31998
M19681
CAJ18395
AAA37684
NP_035463
NW_001030424
NM_011333
BC055070
CAI25305
BAE32062
NW_000039
P10148
CT010187
BAE32019
126846
205334
3091141
55531
81873033
AAA63496
AAC15187
AF058786
AF079313
M57441
NM_031530
NP_113718
P14844
Q549R5
X17053
123790955
123797015
126844
32822882
387168
387169
56205230
6531363
6531365
6531367
6531369
6531371
71059703
74142494
74151961
74152056
74181396
74198942
74201832
81870303
81885950
AAA37685
AAF15379
AAF15380
AAF15381
AAF15382
AAF15383
AAH55070
AF065930
AF065931
AF065932
AF065933
AJ238892
AK132590
AK150937
AK151789
AK153443
AK153468
AK153520
AL626807
Q3U5L6
Q3U5S8
Q5SVU3
Q7TMS1
AI323594
10933861
119600618
123994099
126842
16307255
184642
21435977
240868
30583497
307163
338007
338009
34514
34559720
386961
487124
545465
74738319
992947
NT_086870
NT_110624
240867
51828859
6755429
6755430
17902508
193488
193486
6531362
6531364
6531366
6531368
6531370
34873416
13928713
13928714
3388147
55530
3091140
205333
34513
37544509
56119169
4506841
51474487
21435976
34559719
516772
338005
188701
187447
34001
10933860
55950752
16307254
30583496
187434
184641
338008
545464
NC_007131
NW_001512140
XM_001332867
XP_001332903
119600617
148683709
148683710
148877642
148877899
AAI45868
AAI45870
BC145867
BC145869
CH466556
EDL15656
EDL15657
149053620
EDM05437
126841
148743988
163395
624394
AAA30651
AAA60956
AAI42094
BC142093
L32659
M84602
NC_007317
NM_174006
NP_776431
NW_001493657
P28291
125846719
126007383
793193
Dr.139901
dre:793193

Swiss-Prot ID CCL2_HUMAN
CCL12_MOUSE
D4ABS1_RAT
Q545B5_MOUSE
B2R4V3_HUMAN

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000108691
ENSP00000225831.4
ENST00000225831.4
ENSMUSG00000035352
ENSMUSP00000000194.3
ENSMUST00000000194.3
ENSRNOG00000029768
ENSRNOP00000038407.4
ENSRNOT00000031626.5
ENST00000225831
ENSP00000225831
ENSMUST00000000194
ENSRNOT00000031626
ENSRNOP00000038407
ENSMUSP00000000194

MGI ID MGI:108224
108224
98259
2144120

RGD ID 1309255
3645

Unigene ID Hs.303649
Mm.867
Rn.137780
Rn.4772
Mm.290320
Dr.139901
Bt.2408

Homologene ID 2245

Shape Rhomb

IPI ID IPI00009308
IPI00369956
IPI00788881
IPI00125860
IPI00850699
IPI00850528

Chromosome position 10q26
17q11.2-q21.1
11 46.5 cM

Microarray ID 1367973_at
x17053cds_s_at
A_42_P695401
102736_at
1420380_at
m19681_s_at
A_51_P286737
M26683
M37719
M24545
216598_s_at
34375_at
875_g_at
M26683_at
A_23_P89431
A_14_P125482
OR2485
202
OH3487A
MA418
AH1405
SC169
x17053mrna_s_at
93717_at

Homo sapiens Chromosome position 17q11.2-q12

Ensembl Transcript ID ENST00000225831

FunctionalClass CCR2 chemokine receptor binding
G-protein-coupled receptor binding
chemokine
protein binding
protein kinase
cytokine
signal transducer

Hugo Symbol CCL2

Bos taurus Chromosome position 19

Mus musculus Chromosome position 11 46.5 cM
11

KEGG pathway Cytokine-cytokine receptor interaction

Rattus norvegicus Chromosome position 10q26

Ensembl Gene ID ENSG00000108691