Protein SMAD4

URN urn:agi-llid:4089
Total Entities 0
Connectivity 3771
Name SMAD4
Description SMAD family member 4
Notes This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Immunoglobulin Class-Switch Recombination Activation
AHR Signaling in Treg and Dendritic Cells Function
anti-Inflammatory Function of Macrophage M2 Lineage
Vascular Smooth Muscle Cell/Pericyte Differentiation and Proliferation
PRL Expression Regulation by BMP4 and TGFB1
Activin, Inhibin and Follistatin Action on Pituitary Gland
G1/S Damage Checkpoint
Cell Cycle Overiew
Cardiomyocyte Dysfunction
Dilated Cardiomyopathy
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension
BMP2 and Non-Canonical WNT Signaling in Pulmonary Artery Endothelial Cells
Endothelial Cell Dysfunction in Pulmonary Hypertension
Androgens in Sebocyte Maturation
TGF-beta Signaling in Skin Aging
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Bone Resorption in Hyperparathyroidism
Bone Remodeling in Hyperthyroidism
Prolactinoma Overiew
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
Neurogenic Transcription Factors Role in Hirschsprung Disease
Peutz-Jeghers Syndrome
Proteins Involved in Peutz-Jeghers Syndrome
Chronic Myeloid Leukemia
Vascularization in Hepatocellular Carcinoma
NOTCH Signaling in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
STK11 Signaling in Pancreatic Neoplasms
TGFBR Signaling in Pancreatic Neoplasms
Osteoblast Function Decline in Gout
TGFB2 Signaling Impairement in Osteoarthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Enamel Formation Disruption
Dentin Formation Disruption
Hereditary Hemorrhagic Telangiectasia
Proteins Involved in Hereditary Hemorrhagic Telangiectasia
Myostatin in Skeletal Muscles in Muscular Dystrophies
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Bone Loss in Osteoporosis
Hyperparathyroidism, Secondary Effect
Glioma Stem Cell Program Activation
Medulloblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to NOTCH Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
NOTCH1 Signaling in Breast Cancer
Proteins Involved in Female Infertility
Ovarian Cancer
INHA Gene Mutations in Granulosa Cell Proliferation
FSH Hyperproduction Due to INHA Mutation in Primary Ovarian Insufficiency
BMP Signaling Impairment in Granulosa Cell in POF
Prostate Cancer
Proteins Involved in Prostate Cancer
Proteins Involved in Cataract
Cytokines Trigger Otitis Media
Podocyte Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
BMP6/ACVR2A Expression Targets
BMP2/BMPR2 Expression Targets
BMP7/ACVR2 Expression Targets
BMP4/BMPR2 Expression Targets
BMP15/BMPR2 Expression Targets
BMP7/BMPR2/ACVR2 Expression Targets
Ethanol Induced Hepatotoxicity
Dexamethasone Induced Osteoporosis
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
DNA Damage Checkpoint Impairment in Cancer
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Skeletal Muscle Wasting in Cancer Cachexia
INHBA/ACVR2/BMPR Expression Targets
INHBB/ACVR2 Expression Target
INHBA/ACVR2/ACVR1 Expression Targets
ActivinR/BMPR -> SMAD1/5/9 Signaling
TGFBR/BMPR -> SMAD2/3 Signaling
ActivinR -> SMAD2/3 Signaling
TGFBR -> SMAD1/5/9 Signaling
TGFBR -> MEF/MYOD/MYOG Signaling
TGFBR1/AP-1 Signaling
TDGF1/ACVR2B Expression Targets
MSTN/ACVR2/ACVR1 Expression Targets
AMH/AMHR2 Expression Targets
GDF5/BMPR2/ACVR2 Expression Targets
MSTN/ACVR2/BMPR Expression Targets
NODAL/ACVR2B Expression Targets
TGF-beta Signaling
BMPR2 Signaling
TGFB2-TGFBR1 Expression Targets
TGFB3-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
sars-cov no binding
1_Differentiation of psoriatic T cells
3_TGFB signaling provokes endochondral ossification with osteophyte formation
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
2_Podocyte dysfunction in glomerulonephritis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
3_Arterial wall inflammation and calcification in atherosclerosis
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
1_Inflammatory mediators increase the production of hepcidin (HAMP)
DIPG non histone mutations
DIPG overview_2
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Colorectal Cancer
Genes with Mutations Associated with Pancreatic Cancer
Proteins Involved in Cowden Syndrome
other partners for SARS

MedScan ID 4089

LocusLink ID 4089
17128
50554

Alias transcription factor DPC4
deleted in pancreatic carcinoma protein 4
hSMAD4
MAD (mothers against decapentaplegic, Drosophila) homolog IV
Mothers against decapentaplegic homolog 4
Mothers against decapentaplegic, Drosophila, homolog of, IV
transcription factor Smad4
Smad4 transcription factor
MAD homolog 4
MAD homolog 4 (Drosophila)
DPC4
OTTHUMP00000163548
D18Wsu70e
Madh4
Mothers against DPP homolog 4
SMAD, mothers against DPP homolog 4
OTTMUSP00000023201
Smad 4
OTTMUSP00000023202
JIP
Sma and Mad related protein 4
homolog of Drosophila Mothers against decapentaplegic,, 4
Mothers against DPP homolog IV
SMAD, mothers against DPP homolog IV
MAD, mothers against decapentaplegic homolog 4 (Drosophila)
deletion target in pancreatic carcinoma 4 homolog
MAD (mothers against decapentaplegic Drosophila) homolog 4
MAD (mothers against decapentaplegic homolog IV
Mothers against decapentaplegic, Drosophila, homolog of, 4
MAD homolog IV
Deletion target in pancreatic carcinoma IV
MYHRS gene
AW743858
DNA segment, Chr 18, Wayne State University 70, expressed
deleted in pancreatic carcinoma locus 4
Mothers against decapentaplegic homolog IV
MAD (mothers against decapentaplegic homolog 4
homolog of Drosophila Mothers against decapentaplegic,, IV
Deletion target in pancreatic carcinoma 4
MYHRS
MAD, mothers against decapentaplegic homolog 4
SMAD family member 4
Mothers against DPP homolog 4
SMAD4
MAD (mothers against decapentaplegic, Drosophila) homolog 4
Mothers against DPP homolog IV
hSMAD4s

GO ID 0003677
0001228
0003700
0000981
0070411
0070412
0000978
0001085
0003682
0005518
0046872
0098772
0046982
0042803
0000987
0043565
0043199
0003712
0044212
0030616
0030509
0007183
0060395
0036302
0003190
0007411
0003360
0001658
0008283
0006879
0071773
0048589
0042733
0060956
0042118
0003198
0061040
0048859
0001702
0001701
0070102
0035556
0003220
0048382
0072133
0070373
0010614
1905305
0060548
0030308
0008285
0000122
0045892
0072134
0014033
0048663
0003148
0001541
0030513
0060391
0003251
0010718
0046881
0051571
2000617
0033686
0010862
0045944
1901522
0045893
0030511
0061614
0016579
0070207
0051098
0051797
0017015
0032909
0001666
0071559
0048733
0062009
0072520
0007338
0035019
0032525
0007283
0007179
0060065
0060412
0071141
0032444
0005813
0005737
0005829
0000790
0005654
0005634
0005667
0000977
0046332
0031005
0070371
0009653
0009952
0003279
0030154
0071333
0007492
0008585
0007369
0001822
0008584
0007498
0042177
0001649
0010666
0042127
0006357
0006355
0048729
0042060
0090575
0032991
0030325
0007568
0001076
0000988
0001077
0060021
0006366
0006351
0005622
0043234
0010467
0006367
0005730
0010843
0016563
0045941
0001657
0045449
0006350
0005515
0000976
0000989
0001223
0042802
1902895

KEGG ID hsa:4089
mmu:17128
rno:50554

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 18 49.51 cM
18 48.0 cM

OMIM ID 600993
260350
174900
175050
139210
603391
187300

Rat chromosome position 18q12.2
18q12.3

Hugo ID 6770
HGNC:6770

Human chromosome position 18q21.2
18q21.1

Swiss-Prot Accession A0A024R274
Q13485
Q13485.1
P97471
E3SRG7
P97471.2
O70437
O70437.1
A8K405
Q6GTP6
Q9CW56
Q9BYG6
Q811W8

PIR ID S71811

GenBank ID NC_000018
NM_005359
NP_005350
NG_013013
AB043547
BAB40977
AC091551
AH005874
AAC03051
CH471096
EAW62985
EAW62986
EAW62987
DQ660374
KF572431
AHA34184
KF572432
AHA34185
KF572433
AHA34186
AK290770
BAF83459
AU120224
BC002379
AAH02379
BM701399
BX647129
KU178168
ALQ33626
KU178169
ALQ33627
U44378
AAA91041
Q13485
NC_000084
XM_006525701
XP_006525764
XM_006525702
XP_006525765
XM_011246855
XP_011245157
NM_008540
NP_032566
NM_001364967
NM_001364968
NR_157374
AC132418
AC134447
AY119788
AAM74472
CH466528
EDL09559
EDL09560
EDL09561
AB221585
AK004804
BAB23576
AK170255
AY493561
AAR85497
BC046584
AAH46584
BY742922
GU072917
ADO32891
GU072918
ADO32892
GU072919
ADO32893
GU072920
ADO32894
U79748
AAB57905
P97471
NC_005117
NM_019275
NP_062148
AC_000086
AABR07032518
AAHX01095919
AAHX01095920
AAHX01095921
CH473971
EDM14795
EDM14796
EDM14797
AB010954
BAA83092
AF056002
AAC12781
FQ221613
FQ234113
FQ235244
O70437
NC_018929
AF045438
AF045439
AF045440
AF045441
AF045442
AF045443
AF045444
AF045445
AF045446
AF045447
AMYH02034710
AMYH02034711
AMYH02034712
DQ891840
ABM82766
DQ895028
ABM85954
AC_000040
AAHY01140128
AC_000150
ABBA01018682
ABBA01018683
ABBA01018684
XR_243850
AABR06095872
AABR06095873
AABR06095874
NT_010966
NW_001838468
NW_927106
AC_000061
Q9BYG6
NT_039674
NW_001030635
Q6GTP6
Q811W8
NW_001084736
NW_047516
AK303027
BAG64153
NP_001351896
NP_001351897

Swiss-Prot ID SMAD4_HUMAN
SMAD4_MOUSE
SMAD4_RAT
Q6GTP6_MOUSE
A8K405_HUMAN

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000141646
ENSP00000341551.3
ENST00000342988.7
ENSMUSG00000024515
ENSMUSP00000025393.7
ENSMUST00000025393.13
ENSRNOG00000051965
ENSRNOP00000074882.1
ENSRNOT00000082484.1
ENSP00000341551
ENST00000342988
ENSMUSP00000025393
ENSMUST00000025393
ENSRNOP00000074882
ENSRNOT00000082484
ENSRNOG00000015634
ENSRNOP00000021113
ENSRNOT00000021113
ENST00000342988.8

MGI ID MGI:894293
894293

RGD ID 3033

Unigene ID Hs.75862
Mm.100399
Rn.9774

Homologene ID 31310

Shape O-vertex

IPI ID IPI00013404
IPI00198545
IPI00125567
IPI00556778
IPI00646338
IPI00644112
IPI00644586