Protein IL6R

URN urn:agi-llid:3570
Total Entities 0
Connectivity 2773
Name IL6R
Description interleukin 6 receptor
Notes This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Adipokines Production by Adipocyte
IL6 Expression Targets -> Nociception
Megakaryocyte -> Platelet Precursor Cell Surface Expression Markers
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Pulmonary Hypertension
Lymphocyte Mediated Myocardial Injury in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Vitiligo
Humoral Immunity in Vitiligo
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Proteins Involved in non-Alcoholic Fatty Liver Disease
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
Thyroid Hormones in Adipose Tissue Metabolism
Graves Ophthalmopathy
Adipokines Production by Adipocyte Impaired in Obesity
Metastatic Colorectal Cancer
Th17-Cell Activation in Crohn's Disease
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Mantle Cell Lymphoma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in Multiple Myeloma
Airway Smooth Muscle Cell High Rate Proliferation
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
Th17-Cell Numbers Reduction in HIV
Diabetes Induced Periodontitis
Drugs Targets in Autistic Disoreder (Hypothesis)
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
Bone Loss in Osteoporosis
Genes with Mutations Associated with Rheumatoid Arthritis
Proteins Involved in Glioma
Glioma Stem Cell Program Activation
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Proteins Involved in Endometriosis
IL6/JAK/STAT3 Signaling in Cholesteatoma
Cholesteatoma
Prostate Cancer
Proteins Involved in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
Cytokines Trigger Otitis Media
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
Epithelial to Mesenchymal Transition in Cancer: Overview
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
IL6R -> CEBP/ELK/SRF Signaling
IL6R -> STAT Signaling
IL6 Expression Targets
FOXO1 Signaling
PPAR Psoriasis
Model of PPARG signaling in psoriasis
1_Differentiation of psoriatic T cells
2_The role of endothelial cells in pyelonephritis
2_Cardiomyocyte hypertrophy
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
1_Inflammatory mediators increase the production of hepcidin (HAMP)
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Obesity
Genes with Mutations in GWA Studies of Asthma

MedScan ID 3570

LocusLink ID 3570
16194
24499

Alias interleukin IL6 receptor subunit gp80
interleukin IL6R alpha
IL-6 receptor subunit alpha
IL6R
interleukin IL-6R I
interleukin IL6 receptor, alpha subunit
IL-6R 1
interleukin IL6 receptors
interleukin 6 receptor, alpha
IL6A_HUMAN
IL-6R subunit alpha
interleukin-6 receptor subunit alpha
gp80 subunit IL6 receptor
MGC104991
IL6RA
PIR:I53394
sIL-6R gp80
IL6RQ
IL6R alpha
Soluble interleukin-6 receptors
interleukin IL6A_HUMAN
sIL-6Rs
interleukin IL6 receptor
interleukin IL6RA
MGC30256
membrane glycoprotein 80
IL6A
IL6 receptors
interleukin IL6R
interleukin 6 receptor alpha subunit
interleukin IL-6R 1
Soluble interleukin-6 receptor
IL6 receptor
IL6Q
IL6 receptor subunit gp80
interleukin 6 receptors
interleukin IL6 receptor gp80 subunit
gp80 subunit IL6 receptors
sIL-6R
IL6 receptor gp80 subunit
CD126
interleukin IL6A
CD126 antigen
IL-6R I
interleukin IL6 Receptor alpha
OTTHUMP00000034320
IL6 Receptor alpha
interleukin 6 receptor
gp80
IL-6RA
IL-6R-1
IL-6R
IL-6R-alpha
IL-6 receptor alpha chain
IL6R1
OTTHUMP00000217870
interleukin 6 receptor, alpha subunit
Interleukin-6 receptor alpha

GO ID 0070119
0004897
0019955
0004896
0019899
0008083
0042164
0005143
0045519
0019981
0004915
0005138
0042803
0006953
0070120
0019221
0050829
0031018
0097191
0002384
0070102
0002548
0051135
0002827
0042104
0010536
0008284
0032722
0072126
0032729
0032755
0002690
0050671
0032816
0045669
0050731
0048661
0042531
0034097
0016324
0016323
0070110
0009897
0005576
0043514
0070743
0005896
0005886
0043235
0048589
0032966
0043410
0009986
0005615
0016021
0016020
0032809
0051092
0010469
0051591
0045471
0010332
0051384
0032496
0043434
0050830
0032717
0002446
0042517
0016049
0046427
0042981
0045768
0004872
0007165
0005102
0008283
0007166
0006955
0007275
0004907
0005887

KEGG ID hsa:3570
mmu:16194
rno:24499

MedLine Reference 10331011
10631556
11306811
12604335
2174054
9870869
10066782
10462375
10785334
10982829
11884403
12002769
12008038
12079407
12372336
12412787
12414855
12419823
12445803
12461182
12472176
12477932
12553038
12553555
12574959
12633863
12643274
12748171
12748876
12789531
1281789
12829785
12832423
12857602
1381187
14557255
14592826
14718574
15041717
15063602
15100312
15166129
15213442
15297310
15456942
15561970
15562008
15579373
15641051
15816827
15837717
15895091
16034137
16127269
16372246
16557588
16794539
16912152
16973585
1872801
1889804
2112585
2157217
2261637
2788034
3136546
8056053
8265649
8428753
8467812
9169421
9373149
9927325
11017875
15284182
15489334
16270750
16710414
17310346
17357077
2529343
8125298
10349636
10521784
11042159
11073809
11076861
11197687
11217851
11275690
11937300
12370259
12413742
12429018
12466851
12643284
1312474
14960573
15073037
15191552
15457342
16141072
16141073
16435023
17202339
2051018
7621883
8392875
8477802
8499630
8676083
8770556
8797792
8836549
9034153
9324354
9659221
9708822
9743535
9874564
11171594
11448096
14751512
15084893
7814800

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 3 39.19 cM
3 42.1 cM

OMIM ID 147880
614752
614689

Rat chromosome position 2q34

Hugo ID 6019
HGNC:6019

Human chromosome position 1q21.3
1q21

Swiss-Prot Accession A0N0L5
P08887
A0A087WTB5
P08887.1
A0A0G2JGF1
Q3URV7
P22272
P22272.2
P22273.2
A8KAE8
B2R6V4
Q16202
Q53EQ7
Q5FWG2
Q5VZ23
G3V8T6
P22273
IL6RA_HUMAN
IL6RA_MOUSE
A0N0L5_HUMAN
A8KAE8_HUMAN
Q3URV7_MOUSE

PIR ID A41242
JL0144
JL0145

GenBank ID NC_000001
NM_001206866
NP_001193795
XM_017001199
XP_016856688
XM_006711298
XP_006711361
XM_017001200
XP_016856689
NM_000565
NP_000556
NM_181359
NP_852004
XM_005245139
XP_005245196
XM_017001201
XP_016856690
XM_005245140
XP_005245197
XM_006711299
XP_006711362
NG_012087
AF104230
AL162591
CH471121
EAW53199
EAW53200
EAW53201
CS068586
CAI84624
EF064723
ABK41906
AA035377
AK223582
BAD97302
AK293013
BAF85702
AK312730
BAG35601
BC035327
BC089410
AAH89410
BC132684
AAI32685
BC132686
AAI32687
BM911928
S72848
AAC60635
X12830
CAA31312
X58298
CAA41231
P08887
NC_000069
NM_001310676
NP_001297605
NM_010559
NP_034689
AC102392
CH466547
EDL15180
AK020663
BAB32168
AK046337
AK082270
AK141197
BAE24580
BC038306
BQ033304
X51975
CAA36237
X51976
CAA36238
X53802
CAA37810
P22272
NC_005101
XM_006232588
XP_006232650
XM_006232587
XP_006232649
XM_008761127
XP_008759349
NM_017020
NP_058716
XM_017590628
XP_017446117
AC_000070
AABR07012144
AABR07072754
AAHX01018614
AAHX01018615
AAHX01018616
AAHX01018617
AC094121
AC128343
CH473976
EDM00609
CB778659
M58587
AAA41431
P22273
NC_018912
AMYH02001924
AMYH02001925
HQ258435
ADR83189
HQ258616
ADR83368
XM_006501045
XP_006501108
AC_000025
AAHY01028983
AAHY01028984
AAHY01028985
AAHY01028986
AAHY01028987
AAHY01028988
AAHY01028989
BC019388
BC148583
AAI48584
AC_000133
ABBA01049484
ABBA01049485
ABBA01049486
ABBA01049487
XM_005245138
XP_005245195
XM_006232586
XP_006232648
XM_006232585
XP_006232647
XM_006232589
XP_006232651
AABR06018833
AABR06018834
CAH72853
NT_004487
NW_001838529
NW_925683
AC_000044
NT_039240
NW_001030721
Q3URV7
NW_047626
NW_001084805
Q5FWG2
NW_000191
Q5VZ23
Q53EQ7
204922
729832
119573584
119573585
124343
124375838
124375840
32581
33846
55663065
58476958
62820287
62898896
633863
119573586
123788393
124344
12861314
148683233
151555267
49726
52693
53549
74189907
149048033

Swiss-Prot ID IL6RA_HUMAN
IL6RA_MOUSE
Q3URV7_MOUSE
A0N0L5_HUMAN
A8KAE8_HUMAN

Cell Localization Basolateral cell membrane
Secreted
Membrane
Plasma membrane

Ensembl ID ENSG00000160712
ENSP00000357470.3
ENST00000368485.8
ENSP00000477739.1
ENST00000622330.4
ENSP00000340589.4
ENST00000344086.8
ENSMUSG00000027947
ENSMUSP00000143541.1
ENSMUST00000197679.4
ENSMUSP00000029559.6
ENSMUST00000029559.6
ENSRNOG00000020811
ENSRNOP00000028234.5
ENSRNOT00000028234.7
ENST00000368485.7
ENSP00000357470
ENST00000368485
ENSP00000477739
ENST00000622330
ENSP00000340589
ENST00000344086
ENSMUSP00000029559
ENSMUST00000029559
ENSMUSP00000143541
ENSMUST00000197679
ENSRNOP00000028234
ENSRNOT00000028234

MGI ID MGI:105304
105304

RGD ID 2902

Unigene ID Hs.135087
Mm.2856
Rn.1716
Hs.709210
Hs.591492
Hs.695954

Homologene ID 474

Shape Stick-vertex

IPI ID IPI00031171
IPI00413309
IPI00126188
IPI00205182
IPI00206288

Homo sapiens Chromosome position 1q21

Ensembl Transcript ID ENST00000368485
ENST00000344086

FunctionalClass enzyme binding
interleukin-6 receptor
hematopoietin/interferon-class (D200-domain) cytokine receptor
receptor
interleukin receptor

Mus musculus Chromosome position 3 42.1 cM

KEGG pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Jak-STAT signaling pathway

Rattus norvegicus Chromosome position 2q34

Ensembl Gene ID ENSG00000160712