Protein TLR4

URN urn:agi-llid:7099
Total Entities 0
Connectivity 9293
Name TLR4
Description toll-like receptor 4
Notes The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Cortisol in Resolving Inflammation
Antiviral Signaling through Pattern Recognition Receptors
DC-SIGN (CD209) Signaling
DCIR1 (CLEC4A) Signaling
TLR4 Signaling in Leukocytes
T-Cell Independent B-Cell Activation
Toll-like Receptors in Sterile Inflammation
Necrosis
MC1R in anti-Inflammatory Signaling
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Monoblast -> Promonocyte Surface Expression Markers
Myeloblast -> Neutrophil Surface Expression Markers
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Low-Density Lipoproteins and Chemokines in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Pulmonary Hypertension
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Proteins Involved in Acne Vulgaris
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Proteins Involved in Systemic Lupus Erythematosus
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
Proteins Involved in Diabetes Mellitus Type 1
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Diabetic Neuropathy
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
Thymic Follicular Hyperplasia
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Proteins Involved in Celiac Disease
Celiac Disease
Proteins Involved in Colorectal Neoplasms
Crohn's Disease
Paneth-Cell Function in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
Proteins Involved in Helicobacter Infections
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
Proteins Involved in Antiphospholipid Syndrome
B-Cell Chronic Lymphocytic Leukemia
Proteins Involved in Marginal Zone Lymphoma
Antiphospholipid Antibodies and Endothelial Cell Interaction
Club-Cell Role in Asthma
Antigen-Presenting Cell Role in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Proteins Involved in Cystic Fibrosis
Airway Epithelial Cell Dysfunction
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
Proteins Involved in Gout
Monocytes Function in Gout
Proteins Involved in Osteoarthritis
Dendritic Cell Dysfunction in Psoriatic Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in HIV Type 1 Infection
Toll-like Receptors (TLR) in Periodontitis
Proteins Involved in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Microglia Activation in Alzheimer's Disease
Metals and Amyloid beta Toxicity in Alzheimer's Disease
HMGB1 and IL1B in Neuroinflammation
HMGB1 and IL1B in Neuronal Hyperexcitation
Microglia Activation in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Proteins Involved in Amyotrophic Lateral Sclerosis
Proteins Involved in Endometriosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Cholesteatoma
Cholesteatoma
Proteins Involved in HPV Infection
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Proteins Involved in Age-Related Macular Degeneration
Genes with Mutations Associated with Age-Related Macular Degeneration
Proteins Involved in Hearing Loss
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Proteins with Altered Expression in Chronic Obstructive Pulmonary Disease
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Proteins Involved in Pulmonary Emphysema
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins Involved in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Toll-like Receptors in Pyelonephritis
CSF2 -> NF-kB Expression Targets
NFKB Canonical Signaling Activation in Cancer
NFKB Signaling Activation by Blocking of Tumor Suppressors
IDO1 in Cancer Immune Escape
IFNG/IFNR Expression Targets
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Brain
AGT -> CREB Expression Targets
NF-kB Canonical Signaling
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR9 Expression Targets
TLR4 -> IRF Signaling
TLR4/5/7/9 -> NF-kB Signaling
TLR -> AP-1 Signaling
pathway 4
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative regulators
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of vascular density
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of pregnancy outcome
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of fibroblast phenotype
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of vascular density
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of pregnancy outcome
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of fibroblast phenotype
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of monocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of microglia
Neighbors of hepatocyte
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of stem cell
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of mast cell
Neighbors of neuroglia
Neighbors of podocyte
Neighbors of conventional dendritic cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of heart
Neighbors of gastrointestinal tract
Neighbors of placenta
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of immune system
Neighbors of left ventricle
Neighbors of uterine cervix
Neighbors of omentum
Neighbors of arteriole
Neighbors of bronchus
Neighbors of glands
Neighbors of eye
Neighbors of mammary gland
Neighbors of thymus gland
Neighbors of nasopharynx
Neighbors of lower extremity
Neighbors of small intestine
Neighbors of amniotic cavity
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of ERK1/2
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of adipokine
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of inflammatory cytokine
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of Ang II receptor
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of retinoid-X receptor subfamily
Neighbors of immunoglobulin
Neighbors of TLR1/2 heterodimer
Neighbors of angiotensin receptor
Neighbors of histone
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of phosphoinositide phospholipase C
Neighbors of TLR4/Myd88
Neighbors of TNF-alpha receptor
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
Vg9Vd2 cells-|SARS
AGER feed forward loop in innate immunity
Dendritic Cell Activation in COVID19
Overview. Diseases of the digestive system (chapter 10)
Overview. Diseases of the eye (chapter 6)
Overview. Diseases of the ear (chapter 7)
Overview. Endocrine and metabolic diseases (chapter 4)
1_Inflammation in keratinocytes in the pathology of acne
1_The role of Toll-like receptors in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
1_Low-density lipoprotein internalization and the accumulation of lipids in atherosclerosis
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
1_2_Feedback relations between coagulation and fibrinolysis
4_3_Insulin resistance: FFA-related insulin resistance
2_Ion channel CFTR failure in cystic fibrosis airway epithelium (class III-IV mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
drug-target pairs direct regulation
Model of PPARG signaling in psoriais (tested)

Group Genes with Mutations Associated with Atherosclerosis
Genes Associated with Ulcerative Colitis
Genes with Polymorphisms Associated with Migraine
Genes with Susceptibility Loci Associated with Age-Related Macular Degeneration

MedScan ID 7099

LocusLink ID 7099
21898
29260

Alias hToll
age-related macular degeneration 10
homolog of toll
Ly87
toll-like receptor 4
RP24-209H15.1
Ran/M I
Ran/M1
CD284 antigen
homologue of toll
CD284
OTTHUMP00000022807
antigen CD284
homolog of Drosophila toll
TLR4
toll4
homologue of Drosophila toll
toll-like receptor IV
OTTMUSP00000000296
ARMD10
TOLL
TLR-4
toll like receptor 4 protein
Lps
Rasl2-8
Toll like receptor 4
lipopolysaccharide response
homolog of toll
Ran/M1s

GO ID 0001540
0001530
0001875
0046982
0038023
0005102
0004888
0002322
0007249
0007252
0002755
0002756
0042088
0035666
0000187
0097190
0014002
1904646
0071346
0071222
0071223
0071260
0140052
0050829
0042742
0016046
0032497
0006955
0006954
0045087
0032609
0050702
0060729
0031663
0042116
0070266
0070373
0034128
0120163
0032689
0032700
0032707
0032715
0045671
0032720
0002537
0006909
0030890
0070374
0043123
0046330
0045348
0051092
1901224
1900227
1903974
0032722
1900017
0010628
0050729
0032727
0045359
0032728
0032729
0050718
0032732
0032733
0045084
0032735
0032755
0045416
0032757
0043032
0060907
0045429
0051770
0070430
0070434
1903223
0010572
1903428
0045944
0042535
0032760
0002730
0032496
0034142
0002224
0009986
0005737
0005769
0010008
0009897
0005887
0031226
0046696
0048471
0001891
0005886
0043235
0043548
0007250
0002218
0050966
0050965
0002376
0002758
0006691
0045576
0001774
0043388
0051091
0043065
0045362
0045368
0045410
0050671
0050731
0032874
0050727
0051930
1904467
0009617
0045471
0070542
0006979
0007165
0005768
0016021
0016020
0045121
0071300
0016064
0014823
0051384
1990268
0001666
0032868
0043278
0032570
0032526
0009636
0003009
0005622
0050707
0005515
0008063
0038123
0038124
0004872
0002282
0034134
0034138
0034130
0042346
0052033
0010552
0031224
0070391
0003824
0008152
0016045

KEGG ID hsa:7099
mmu:21898
rno:29260

MedLine Reference 10359581
10426995
10524757
10734131
10835634
10952994
11081518
11104518
11254600
11466383
11477091
11490012
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11728442
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11782555
11836257
11841848
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11877429
11893689
11912201
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11964313
11970998
11976338
12045108
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12124407
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12411706
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12495941
12525572
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12630564
12717385
12724322
12730365
12734376
12738639
12742999
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12773319
12777373
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12794153
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12810071
12832426
12846053
12855579
12865424
12874320
12897738
12923493
12925853
12941697
12942028
12957699
12960171
12964127
14517278
14519765
14556004
14557267
14563652
14565959
14578307
14597728
14600154
14610481
14638766
14693986
14699116
14699155
14706103
14709406
14764599
15016407
15022344
15039334
15041961
15044215
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12616494
14599981
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15060019
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16879219
16954392
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17446308
17512285
17560208

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 4 34.66 cM
4 33.0 cM

OMIM ID 603030
611488
114500
152430

Rat chromosome position 5q24

Hugo ID 11850
HGNC:11850

Human chromosome position 9q33.1
9q32-q33

Swiss-Prot Accession O00206
O00206.2
L0CL36
Q9QUK6
Q9QUK6.1
Q9QX05
Q9QX05.1
A8K1Y8
A9XLP9
A9XLQ0
A9XLQ1
B4E194
D1CS52
D1CS53
Q5VZI8
Q5VZI9
Q9UK78
Q9UM57
Q9D691
Q9QZF5
Q9Z203
Q3U4D4
Q8K2T5

GenBank ID NC_000009
NM_003266
NP_003257
NM_138554
NP_612564
NM_138557
NP_612567
NG_011475
AF177765
AAF05316
AF177766
AAF07823
AH009665
AAF89753
AL160272
CH471090
EAW87448
EAW87449
EAW87451
DQ018107
AAY82267
DQ018108
AAY82268
DQ018109
AAY82269
DQ018110
AAY82270
EF535829
EF535830
EF535831
ABU41662
EF535832
ABU41663
EF535833
ABU41664
FB700885
CAS02255
GM869034
CAT16978
GQ903698
ACX46980
GQ903699
ACX46981
GQ903700
ACX46982
GQ903701
ACX46983
GQ903702
ACX46984
GU071276
GU143417
ACZ69536
GU143418
GU143419
ACZ69537
GU143420
ACZ69538
GU143421
ACZ69539
GU143423
GU143424
ACZ69540
GU143425
ACZ69541
GU143426
ACZ69542
GU143427
ACZ69543
JQ480853
AFX71929
JQ480854
AFX71930
JQ480855
AFX71931
JQ480856
AFX71932
JQ480857
AFX71933
JQ480858
AFX71934
JQ480859
AFX71935
JQ480860
AFX71936
JQ480861
AFX71937
JQ480862
AFX71938
JQ480863
AFX71939
JQ480864
AFX71940
JQ480865
AFX71941
JQ480866
AFX71942
JQ480867
AFX71943
JQ480868
AFX71944
JQ480869
AFX71945
JQ480870
AFX71946
JQ480871
AFX71947
JQ480872
AFX71948
JQ480873
AFX71949
JQ480874
AFX71950
JQ480875
AFX71951
JQ480876
AFX71952
JQ480877
AFX71953
JQ480878
AFX71954
JQ480879
AFX71955
JQ480880
AFX71956
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AFX71958
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AFX71962
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AFX71975
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AFX71976
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AFX71980
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AFX71981
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AFX71989
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AFX71992
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AFX71999
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AFX72000
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AFX72005
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AFX72021
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AFX72125
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AFX72188
JQ481113
AFX72189
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AFX72190
JQ481115
AFX72191
JQ481116
AFX72192
JQ481117
AFX72193
JQ481118
AFX72194
JQ481119
AFX72195
JQ481120
AFX72196
JQ481121
AFX72197
JQ481122
AFX72198
JQ481123
AFX72199
JQ481124
AFX72200
JQ481125
AFX72201
JQ481126
AFX72202
JQ481127
AFX72203
JQ481128
AFX72204
JQ481129
AFX72205
JQ481130
AFX72206
JQ481131
AFX72207
JQ481132
AFX72208
JQ481133
AFX72209
JQ481134
AFX72210
JQ481135
AFX72211
JQ481136
AFX72212
JQ481137
AFX72213
JQ481138
AFX72214
JQ481139
AFX72215
JQ481140
AFX72216
JQ481141
AFX72217
JQ481142
AFX72218
JQ481143
AFX72219
JQ481144
AFX72220
JQ481145
AFX72221
JQ481146
AFX72222
JQ481147
AFX72223
JQ481148
AFX72224
JQ481149
AFX72225
JQ481150
AFX72226
JQ481151
AFX72227
JQ481152
AFX72228
JQ481153
AFX72229
JQ481154
AFX72230
JQ481155
AFX72231
JQ481156
AFX72232
JQ481157
AFX72233
JQ481158
AFX72234
JQ481159
AFX72235
JQ481160
AFX72236
JQ481161
AFX72237
JQ481162
AFX72238
JQ481163
AFX72239
JQ481164
AFX72240
JQ481165
AFX72241
JQ481166
AFX72242
JQ481167
AFX72243
JQ481168
AFX72244
JQ481169
AFX72245
JQ481170
AFX72246
JQ481171
AFX72247
JQ481172
AFX72248
JQ481173
AFX72249
JQ481174
AFX72250
JQ481175
AFX72251
JQ481176
AFX72252
JQ481177
AFX72253
JQ481178
AFX72254
JQ481179
AFX72255
JQ481180
AFX72256
JQ481181
AFX72257
JQ481182
AFX72258
JQ481183
AFX72259
JQ481184
AFX72260
JQ481185
AFX72261
JQ481186
AFX72262
JQ481187
AFX72263
JQ481188
AFX72264
JQ481189
AFX72265
JQ481190
AFX72266
JQ481191
AFX72267
JQ481192
AFX72268
JQ481193
AFX72269
JQ481194
AFX72270
JQ481195
AFX72271
JQ481196
AFX72272
JQ481197
AFX72273
JQ481198
AFX72274
JQ481199
AFX72275
JQ481200
AFX72276
JQ481201
AFX72277
JQ481202
AFX72278
JQ481203
AFX72279
JQ481204
AFX72280
JQ481205
AFX72281
JQ481206
AFX72282
JQ481207
AFX72283
JQ481208
AFX72284
JQ481209
AFX72285
JQ481210
AFX72286
JQ481211
AFX72287
JQ481212
AFX72288
JQ481213
AFX72289
JQ481214
AFX72290
JQ481215
AFX72291
JQ481216
AFX72292
JQ481217
AFX72293
JQ481218
AFX72294
JQ481219
AFX72295
JQ481220
AFX72296
JQ481221
AFX72297
JQ481222
AFX72298
JQ481223
AFX72299
JQ481224
AFX72300
JQ481225
AFX72301
JQ481226
AFX72302
JQ481227
AFX72303
JQ481228
AFX72304
JQ481229
AFX72305
JQ481230
AFX72306
JQ481231
AFX72307
JQ481232
AFX72308
JQ481233
AFX72309
JQ481234
AFX72310
JQ481235
AFX72311
JQ481236
AFX72312
JQ481237
AFX72313
JQ481238
AFX72314
JQ481239
AFX72315
JQ481240
AFX72316
JQ481241
AFX72317
MG385628
AZI70866
AA598398
AB445638
BAG55035
AK226155
AK290053
BAF82742
AK293068
BAF85757
AK303730
BAG64706
AL710219
BC025294
BC117422
AAI17423
BC143841
BG622357
DA126770
DA187988
DA218006
U69193
U88880
AAC34135
U93091
AAC80227
O00206
NC_000070
NM_021297
NP_067272
AF177767
AAF05317
AL805946
CAD83014
BX649609
CH466527
EDL31078
KC811649
AGX25444
KC811650
AGX25445
KC811651
AGX25446
KC811652
AGX25447
KC811653
AGX25448
KC811654
AGX25449
KC811655
AGX25450
KC811656
AGX25451
KC811657
AGX25452
KF696867
AGY29656
KF696868
AGY29657
KF696869
AGY29658
KF696870
AGY29659
KF696871
AGY29660
KF696872
AGY29661
KF696873
AGY29662
KF696874
AGY29663
KF696875
AGY29664
KF696876
AGY29665
KF696877
AGY29666
KF696878
AGY29667
KF696879
AGY29668
KF696880
AGY29669
KF696881
AGY29670
KF696882
AGY29671
KF696883
AGY29672
KF696884
AGY29673
KF696885
AGY29674
KF696886
AGY29675
KF696887
AGY29676
KF696888
AGY29677
KF696889
AGY29678
KF696890
AGY29679
KF696891
AGY29680
KF696892
AGY29681
KF696893
AGY29682
KF696894
AGY29683
KF696895
AGY29684
KF696896
AGY29685
KF696897
AGY29686
KF696898
AGY29687
KF696899
AGY29688
KF696900
AGY29689
KF696901
AGY29690
KF696902
AGY29691
KF696903
AGY29692
KF696904
AGY29693
KF696905
AGY29694
KF696906
AGY29695
KF696907
AGY29696
KF696908
AGY29697
KF696909
AGY29698
KF696910
AGY29699
KF696911
AGY29700
KF696912
AGY29701
KF696913
AGY29702
KF696914
AGY29703
KF696915
AGY29704
KF696916
AGY29705
KF696917
AGY29706
KF696918
AGY29707
KF696919
AGY29708
KF696920
AGY29709
KF696921
AGY29710
KF696922
AGY29711
KF696923
AGY29712
KF696924
AGY29713
KF696925
AGY29714
KF696926
AGY29715
KF696927
AGY29716
KF696928
AGY29717
KF696929
AGY29718
KF696930
AGY29719
KF696931
AGY29720
KF696932
AGY29721
KF696933
AGY29722
KF696934
AGY29723
KF696935
AGY29724
KF696936
AGY29725
KF696937
AGY29726
KF696938
AGY29727
KF696939
AGY29728
KF696940
AGY29729
KF696941
AGY29730
KF696942
AGY29731
KF696943
AGY29732
KF696944
AGY29733
KF696945
AGY29734
KF696946
AGY29735
KF696947
AGY29736
KF696948
AGY29737
KF696949
AGY29738
KF696950
AGY29739
KF696951
AGY29740
KF696952
AGY29741
KF696953
AGY29742
KF696954
AGY29743
KF696955
AGY29744
KF696956
AGY29745
KF696957
AGY29746
KF696958
AGY29747
KF696959
AGY29748
KF696960
AGY29749
KF696961
AGY29750
KF696962
AGY29751
KF696963
AGY29752
KF696964
AGY29753
KF696965
AGY29754
KF696966
AGY29755
KF696967
AGY29756
AF095353
AAC99411
AF110133
AAD29272
AF185285
AAF04278
AI450864
AK014533
AK030348
AK154297
BAE32498
AK170566
BC029856
AAH29856
BX514079
CD544295
JX878358
AGA16685
JX878359
AGA16686
Q9QUK6
NC_005104
NM_019178
NP_062051
AC_000073
AABR07048553
AAHX01037335
CH473978
EDM10505
AF057025
AAC13313
EU929065
ACI15385
FQ233814
GQ175880
ACS45118
Q9QX05
AF172171
XP_005252239
CAH72619
CAH72618
AC_000141
XM_005252182
AMYH02021544
CAI26152
AABR06037636
AAHY01036550
CAM27682
AC_000026
NC_018920
ABBA01016273
NR_024168
NR_024169
NT_008470
NW_001839237
NW_924573
AC_000052
NT_039260
NW_001030747
Q3U4D4
Q8K2T5
NW_001084840
NW_047714
NT_039288
109659094
119607857
20140413
2429103
2459628
55662033
55662034
6175873
6403467
74747809
74747810
74747811
9622357
Q5VZI7
Q5VZI8
Q5VZI9
123784217
148699131
20140894
20988279
4092077
4761197
56238167
6120054
6175875
74178484
81870258
81878581
AV230010
Q5RGT4
149059567
20140357
3044208

Swiss-Prot ID TLR4_HUMAN
TLR4_MOUSE
TLR4_RAT
D1CS53_HUMAN

Cell Localization Cell membrane
Early endosome
Membrane
Plasma membrane

Ensembl ID ENSG00000136869
ENSP00000377997.4
ENST00000394487.5
ENSP00000494590.1
ENST00000645071.1
ENSMUSG00000039005
ENSMUSP00000045770.5
ENSMUST00000048096.11
ENSRNOG00000010522
ENSRNOP00000014020.2
ENSRNOT00000014020.3
ENSRNOT00000014020
ENSP00000363089
ENSP00000363089.5
ENST00000355622
ENSP00000377997
ENSMUST00000048096
ENST00000355622.7
ENST00000394487
ENSRNOP00000014020
ENSMUSP00000045770

MGI ID MGI:96824
96824

RGD ID 3870

TCDB ID 8.A.43.1.9

Unigene ID Rn.14534
Hs.174312
Mm.38049

Homologene ID 41317

Shape Stick-vertex

IPI ID IPI00212570
IPI00131730
IPI00914904
IPI00008673
IPI00374265
IPI00649472

Homo sapiens Chromosome position 9q32-q33

Ensembl Transcript ID ENST00000355622

FunctionalClass lipopolysaccharide binding
protein binding
transmembrane receptor
catalytic
receptor
phosphoinositide 3-kinase binding

Mus musculus Chromosome position 4 33.0 cM

KEGG pathway Toll-like receptor signaling pathway

Rattus norvegicus Chromosome position 5q24

Ensembl Gene ID ENSG00000136869