Protein IL17F

URN urn:agi-llid:112744
Total Entities 0
Connectivity 1228
Name IL17F
Description interleukin 17F
Notes The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand

Pathway AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Th17-Cell Activation in Crohn's Disease
Il17 Signaling Related Neutrophilia in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
Proteins Involved in Endometriosis
Cytokines Trigger Otitis Media
Proteins with Altered Expression in Asthma
IL21 Expression Targets
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of bacterial load
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of microvessel density
Neighbors of neutrophil count
Neighbors of bone mineral density
Neighbors of cancer risk
Neighbors of gastric cancer risk
Neighbors of insulin level
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of bacterial load
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of microvessel density
Neighbors of neutrophil count
Neighbors of bone mineral density
Neighbors of cancer risk
Neighbors of gastric cancer risk
Neighbors of insulin level
Neighbors of cell development
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of osteoclast differentiation
Neighbors of tissue remodeling
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of tissue repair
Neighbors of cell infiltration
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of adipogenesis
Neighbors of pregnancy
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of neutrophil recruitment
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of immune system function
Neighbors of autophagy
Neighbors of cell transdifferentiation
Neighbors of cell growth
Neighbors of sensitization
Neighbors of cellular immune response
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of airway inflammation
Neighbors of infection
Neighbors of renal injury
Neighbors of macrophage infiltration
Neighbors of sepsis
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of diabetic nephropathy
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of kidney disease
Neighbors of lung disease
Neighbors of cancer
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of respiratory hypersensitivity
Neighbors of synovitis
Neighbors of hypertrophy
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of monocyte
Neighbors of macrophage
Neighbors of PBMC
Neighbors of pneumocyte
Neighbors of mononuclear cell
Neighbors of inflammatory cell
Neighbors of neutrophil
Neighbors of activated T-cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of mast cell
Neighbors of spleen cell
Neighbors of hematopoietic cell
Neighbors of lymphocyte
Neighbors of thymic epithelial cell
Neighbors of lymphoid cell
Neighbors of blood cell
Neighbors of lymph node cell
Neighbors of kidney
Neighbors of colon
Neighbors of synovial membrane
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of peritoneum
Neighbors of NF-kB family
Neighbors of IL1 family
Neighbors of PI3K
Neighbors of STAT family
Neighbors of IFNAR ligand
Neighbors of interleukin
Neighbors of JAK
Neighbors of IL23
Neighbors of IL1R
Neighbors of IL12
Neighbors of STAT5
Neighbors of retinoid-X receptor subfamily
Neighbors of RA receptor
Neighbors of TLR4/Myd88
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway (3)
1_Differentiation of psoriatic T cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
3_2_Regulation of airway surface liquid (ASL) thickness
2_3_Eosinophilia and neutrophilia in asthma: Neutrophil chemotaxis and activation
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
4_1_Polymorphisms associated with inflammatory bowel diseases
Model of PPARG signaling in psoriais (tested)
Differentiation of psoriatic T cells
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 112744

LocusLink ID 112744
257630
301291

Alias cytokine ML I
interleukin IL17F
interleukin 17F
MGC114402
cytokine ML-1
IL17F
CANDF6
ML-1
C87042
ML1
IL-17F
interleukin-17F

GO ID 0005125
0019955
0005126
0042803
0051216
0042089
0019221
0006954
0097400
0042109
0016525
1900017
2000778
0045944
0045423
0045076
0045408
0045414
0017015
0005576
0005615
0010469
0007166
0006029

KEGG ID hsa:112744
mmu:257630
rno:301291

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 1

OMIM ID 606496
613956

Rat chromosome position 9q13

Hugo ID 16404
HGNC:16404

Human chromosome position 6p12.2
6p12

Swiss-Prot Accession Q96PD4
Q96PD4.3
Q7TNI7
Q7TNI7.1
Q5BJ95
Q5BJ95.2
Q6NSI0
Q7Z6P4
Q96PI8
Q9NUE6
Q8K4C3

GenBank ID NC_000006
XM_011514276
XP_011512578
NM_052872
NP_443104
NG_031869
AL034343
CH471081
EAX04363
EAX04364
CS399130
CAL44888
GM832011
CAV28581
JA104581
CCA63960
JA381711
CCB07362
AF332389
AAL14427
AF384857
AAK83350
BC070124
AAH70124
JF305974
ADY18335
Q96PD4
NC_000067
NM_145856
NP_665855
XM_006495523
XP_006495586
AC159614
CH466536
EDL14379
GM832044
CAV28592
AB116259
BAC81535
AF458064
AAM77568
AK157101
BAE33962
AY380822
AAQ88439
BC145977
Q7TNI7
NC_005108
NM_001015011
NP_001015011
AC_000077
AABR07067030
AAHX01058668
CH473987
EDM18651
BC091568
AAH91568
Q5BJ95
NC_018917
AMYH02013730
XM_006495522
XP_006495585
AC_000023
AAHY01004447
BC160259
AAI60259
AC_000138
ABBA01050558

Swiss-Prot ID IL17F_HUMAN
IL17F_MOUSE
IL17F_RAT

Cell Localization Secreted

Ensembl ID ENSG00000112116
ENSP00000337432.4
ENST00000336123.4
ENSMUSG00000041872
ENSMUSP00000046960.3
ENSMUST00000039046.9
ENSMUSP00000140122.1
ENSMUST00000189301.1
ENSRNOG00000012509
ENSRNOP00000016717.6
ENSRNOT00000016717.5
ENSP00000337432
ENST00000336123
ENSMUSP00000046960
ENSMUST00000039046
ENSMUSP00000140122
ENSMUST00000189301
ENSRNOP00000016717
ENSRNOT00000016717

MGI ID MGI:2676631

RGD ID 1311398

Unigene ID Hs.272295
Mm.222807
Rn.34022

Homologene ID 17115

Shape Rhomb