URN | urn:agi-llid:246778 |
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Total Entities | 0 |
Connectivity | 1939 |
Name | IL27 |
Description | interleukin 27 |
Notes | The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Extracellular |
Class | Ligand |
Pathway | Th1-Cell Differentiation |
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AHR Signaling in Tr1 Cells Function | |
Eosinophil Survival by Cytokine Signaling | |
Dendritic Cells Function in Atherosclerosis | |
Th1-Cells Activation and Proliferation in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Atopic Dermatitis | |
Proteins Involved in Psoriasis | |
T-Cells Differentiation Block in Psoriasis | |
Dendritic Cells Function in Psoriasis | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
CD4+T-Cell Response in Celiac Disease | |
Th1-Cell Activation in Crohn's Disease | |
Genes with Susceptibility for Crohn's Disease and Ulcerative Colitis | |
Proteins Involved in Rheumatoid Arthritis | |
Proteins Involved in Chronic Obstructive Pulmonary Disease | |
Proteins Involved in Glomerulonephritis | |
IL27R -> STAT Signaling | |
C5AR1 -> Expression Targets in Lymphoid System and Blood | |
Elevated Receptors -> Expression Targets in Spleen | |
Elevated Receptors -> Expression Targets in Thymus | |
TLR4 -> NF-kB/IRF Expression Targets | |
PPAR Psoriasis | |
1_Differentiation of psoriatic T cells | |
4_1_Polymorphisms associated with inflammatory bowel diseases | |
Differentiation of psoriatic T cells |
Group | Genes with Mutations Associated with Inflammatory Bowel Diseases |
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MedScan ID | 246778 |
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LocusLink ID | 246778 |
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246779 | |
365368 |
Alias | interleukin 27 |
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IL-27 p28 subunit | |
interleukin-12p35-related protein p28 | |
interleukin-27 receptor ligand activity | |
interleukin IL30 | |
RGD1561420 | |
IL30 | |
IL-27 subunit alpha | |
interleukin-27 subunit alpha | |
interleukin-27 receptor ligand | |
IL27 | |
interleukin IL27p28 | |
IL-12p35-related protein p28 | |
interleukin IL27 | |
interleukin IL-27 subunit | |
interleukin-27 receptor ligands | |
IL27p28 | |
IL-27A | |
interleukin IL-27 p28 subunit | |
interleukin 27A | |
IL-27 subunit | |
MGC71873 | |
interleukin 30 | |
interleukin IL-27A | |
OTTHUMP00000122516 | |
p28 | |
IL-27 | |
IL27A | |
IL-27-A | |
IL27-A | |
interleukin-30 | |
IL-27p28 |
GO ID | 0005125 |
---|---|
0045523 | |
0005102 | |
0006954 | |
0045087 | |
0070106 | |
0002230 | |
0045078 | |
0042129 | |
0045625 | |
0009617 | |
0005829 | |
0005788 | |
0005576 | |
0005615 | |
0002376 | |
0010469 | |
0050688 |
KEGG ID | hsa:246778 |
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mmu:246779 | |
rno:365368 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 7 |
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OMIM ID | 608273 |
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Rat chromosome position | 1q36 |
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Hugo ID | 19157 |
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HGNC:19157 |
Human chromosome position | 16p12.1-p11.2 |
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16p11 |
Swiss-Prot Accession | Q8NEV9 |
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Q8NEV9.2 | |
Q8K3I6 | |
Q8K3I6.1 | |
A0N0L2 | |
Q6P676 | |
D3ZPW3 |
Swiss-Prot ID | IL27A_HUMAN |
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IL27A_MOUSE | |
D3ZPW3_RAT |
Cell Localization | Secreted |
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Extracellular |
Ensembl ID | ENSG00000197272 |
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ENSP00000349365.1 | |
ENST00000356897.1 | |
ENSMUSG00000044701 | |
ENSMUSP00000054637.5 | |
ENSMUST00000058429.5 | |
ENSP00000349365 | |
ENST00000356897 | |
ENSMUSP00000054637 | |
ENSMUST00000058429 |
MGI ID | MGI:2384409 |
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2384409 |
RGD ID | 1561420 |
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Unigene ID | Hs.528111 |
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Mm.222632 |
Homologene ID | 17087 |
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Shape | Rhomb |
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IPI ID | IPI00302598 |
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IPI00170089 | |
IPI00766159 | |
IPI00361203 |