Protein TIRAP

URN urn:agi-llid:114609
Total Entities 0
Connectivity 418
Name TIRAP
Description toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Notes The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
ObjectType Protein

Pathway I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Toll-like Receptors Act through MYD88-TIRAP Signaling
TLR4 Signaling in Leukocytes
Toll-like Receptors in Sterile Inflammation
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Adipokines Production by Adipocyte
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Inflammatory Reaction in Acne Vulgaris
Dendritic Cells Function in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Insulin Resistance in Myocytes Induced by Obesity
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Adipokines Production by Adipocyte Impaired in Obesity
Celiac Disease
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Club-Cell Role in Asthma
Antigen-Presenting Cell Role in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
Monocytes Function in Gout
Dendritic Cell Dysfunction in Psoriatic Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Toll-like Receptors (TLR) in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
HMGB1 and IL1B in Neuroinflammation
HMGB1 and IL1B in Neuronal Hyperexcitation
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Toll-like Receptors in Pyelonephritis
NFKB Canonical Signaling Activation in Cancer
NFKB Signaling Activation by Blocking of Tumor Suppressors
NF-kB Canonical Signaling
TLR4 -> AP-1 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR4 -> IRF Signaling
TLR4/5/7/9 -> NF-kB Signaling
TLR -> AP-1 Signaling
pathway 4
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
sars-cov no binding
AGER feed forward loop in innate immunity
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
1_The role of Toll-like receptors in pyelonephritis
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
4_3_Insulin resistance: FFA-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell

Group other partners for SARS

MedScan ID 114609

LocusLink ID 114609
117149
680127

Alias C130027E04
adapter Mal
FLJ42305
Tlr4ap
wyatt
adaptor protein Wyatt
BACTS1
toll-like receptor 4 adaptor protein
MAL/TIRAP
C130027E04Rik
Toll/IL-1 receptor-associated protein
Toll/IL1 receptor associated protein
MyD88-2
TIRAP/MAL
TIR domain containing adaptor protein
OTTHUMP00000179130
LOC681662
LOC115469
AA407980
RIKEN cDNA C130027E04 gene
Toll/IL-1 receptor associated protein
Toll/IL1 receptor-associated protein
TIRAP
OTTHUMP00000179132
Mal
MyD88 adapter-like protein
Toll-like receptor adaptor protein
adapter protein wyatt
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
toll/interleukin-1 receptor domain-containing adapter protein
TIR domain-containing adapter protein
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
toll-like receptor 4 adapter protein

GO ID 0035663
0035662
0005546
0030674
0046982
0042803
0005080
0070935
0002755
0035665
0007250
0007166
0071221
0071223
0050830
0006954
0045087
0030099
0044130
0030890
0070374
0043123
0046330
0051092
2000340
2000343
0032735
0032738
0045410
0032757
0090023
0090073
0034137
0034141
0034145
0032760
0045088
0032648
0032496
0005737
0005829
0030139
0005886
0032587
0007249
0007257
0002376
0070498
0045089
0032658
0009617
0007165
0034146
0016020
0005777
0005622
0034142
0045171
0034134
0038123
0038124
0005654
0002224
0008063
0034130
0072568
0004888
0031224
0032722

KEGG ID hsa:114609
mmu:117149
rno:680127

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 9

OMIM ID 606252
614382
610799
607948
611162

Rat chromosome position 8q21

Hugo ID 17192
HGNC:17192

Human chromosome position 11q24.2

Swiss-Prot Accession A0A024R3M4
P58753
P58753.2
H3BKL1
Q542S6
Q3UB38
Q99JY1
Q99JY1.1
D3ZXA5
B3KW65
Q56UH9
Q56UI0
Q8N5E5
Q91ZW0

GenBank ID NC_000011
NM_001039661
NP_001034750
NM_001318777
NP_001305706
NM_148910
NP_683708
NM_001318776
NP_001305705
NG_011523
AP001318
AY282416
AAP31973
CH471065
EAW67687
EAW67688
EAW67689
GU646880
AB446477
BAG55254
AF378129
AAL05627
AF406652
AAL01160
AF410783
AAL05036
AK124298
BAG54027
AK313147
BAG35965
AY576785
AAT90417
AY576786
AAT90418
AY576787
AAT90419
BC032474
AAH32474
P58753
NC_000075
NM_001177845
NP_001171316
NM_001177846
NP_001171317
NM_054096
NP_473437
NM_001177847
NP_001171318
AC140448
CH466522
EDL25378
EDL25379
EDL25380
AF378130
AAL05628
AF410784
AAL05037
AK036431
BAC29426
AK080135
BAC37831
AK081514
AK151117
BAE30126
AK168494
BAE40381
BC005584
AAH05584
BY507516
BY740695
BY743490
Q99JY1
NC_005107
XR_001839296
XM_017596001
XP_017451490
XM_017596002
XP_017451491
XM_001055833
XP_001055833
XM_017596003
XP_017451492
XM_017596000
XP_017451489
AC_000076
XR_001844589
XM_017603603
XP_017459092
XM_017603604
XP_017459093
XM_002727021
XP_002727067
XM_017603605
XP_017459094
XM_017603602
XP_017459091
AAHX01054041
AAHX01054042
AC111781
CH474007
EDL83279
EDL83280
XR_356167
AABR06054057
XR_356166
DQ894164
ABM85090
XP_005271456
XR_428968
XP_006226425
DQ890988
XM_005271399
XP_006242856
AC_000031
ABBA01031224
XM_006226363
XM_011542576
XM_011542577
XM_011542578
XM_011542579
AC_000143
XM_011542580
XM_011542581
NC_018922
XM_011542582
AAHY01077101
ABM81914
XM_006242794
XP_011540884
XP_011540881
XP_011540880
XP_011540883
XP_011540882
XR_348402
XR_348403
XP_011540878
AMYH02025746
XP_011540879
NT_033899
NW_001838043
NW_925173
AC_000054
Q56UH9
NT_039472
NW_001030907
Q3UB38
Q542S6
NW_001084868
NW_047799

Swiss-Prot ID TIRAP_HUMAN
TIRAP_MOUSE
Q3UB38_MOUSE
Q56UH9_HUMAN
Q542S6_MOUSE

Cell Localization Cytoplasm
Cell membrane
Membrane

Ensembl ID ENSG00000150455
ENSP00000376447.2
ENST00000392680.6
ENSP00000376446.1
ENST00000392679.5
ENSP00000376445.3
ENST00000392678.7
ENSMUSG00000032041
ENSMUSP00000135435.1
ENSMUST00000175765.7
ENSMUSP00000135876.1
ENSMUST00000176685.7
ENSMUSP00000135462.1
ENSMUST00000177129.7
ENSMUSP00000135224.1
ENSMUST00000176531.7
ENSRNOG00000021420
ENSRNOP00000032025.5
ENSRNOT00000038312.5
ENSMUSP00000135435
ENSMUSP00000135876
ENSMUST00000176685
ENSP00000436967
ENST00000392680
ENST00000479770
ENSMUSP00000135462
ENSMUST00000177129
ENSMUST00000176531
ENSMUSP00000135224
ENSMUST00000175765
ENSRNOT00000038312
ENST00000392678
ENST00000392679
ENSP00000376445
ENSP00000376446
ENSP00000376447
ENSRNOP00000032025

MGI ID MGI:2152213
2152213

RGD ID 1595496

Unigene ID Mm.23987
Hs.537126

Homologene ID 14285

IPI ID IPI00104143
IPI00171090
IPI00718966
IPI00320042
IPI00606468
IPI00370462
IPI00388057

Ensembl Gene ID ENSG00000150455