Protein IFNAR2

URN urn:agi-llid:3455
Total Entities 0
Connectivity 336
Name IFNAR2
Description interferon alpha and beta receptor subunit 2
Notes The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway AXL Receptor Inhibits Macrophages and Dendritic Cells Function
SOCS in Negative Feedback Regulation in Myocarditis
T-Cells Differentiation Block in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Dendritic Cell Dysfunction in Psoriatic Arthritis
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
IFNW1/IFNR Expression Target
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
AXL Receptor Tyrosine Kinase Signaling
PPAR Psoriasis
New Pathway (3)
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
1_Differentiation of psoriatic T cells
drug-target pairs binding
drug-target pairs direct regulation
Differentiation of psoriatic T cells

MedScan ID 3455

LocusLink ID 3455
15976
686326

Alias IFN-R-2
interferon alpha/beta receptor 2
INR2
OTTHUMP00000067675
IMD45 locus
interferon (alpha and beta) receptor II
IFNABR
interferon receptor JFNAR 2 II
OTTHUMP00000067676
LOC194555
INR2_HUMAN
type I interferon receptor 2
LOC686326
Interferon alpha/beta receptor II
interferon (alpha, beta and omega) receptor 2
interferon alpha and beta receptor subunit 2
interferon (alpha and beta) receptor 2
type I interferon receptor soluble isoform
interferon receptor 2c
type I interferon alpha/beta receptor 2a
AI747302
OTTMUSP00000046708
IFNARB
human interferon alpha/beta receptor
IFNAR2
interferon-alpha/beta receptor beta chain
OTTHUMP00000206687
OTTHUMP00000067674
interferon receptor 2a'
OTTMUSP00000033777
interferon receptor JFNAR 2-2
IFN-alpha/beta receptor 2
OTTMUSP00000046710
interferon receptor 2
interferon (alpha, beta and omega) receptor II
IFN-R
IMD45
IFN-alpha-REC
interferon alpha binding protein
interferon receptor
Ifnar-2
IFN-alpha binding protein
interferon-alpha/beta receptor 2

GO ID 0004896
0019901
0004905
0007259
0007166
0019221
0051607
0060338
0035455
0035456
0009615
0060337
0005576
0005887
0005886
0019962
0008283
0006357
0005615
0016021
0016020
0005622
0005515
0042015

KEGG ID hsa:3455
mmu:15976

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 16 52.82 cM
16 63.1 cM

OMIM ID 602376
610424
616669

Rat chromosome position 11q11
11

Hugo ID 5433
HGNC:5433

Human chromosome position 21q22.11

Swiss-Prot Accession P48551
Q9BUA0
P48551.1
O35664
Q9D1R7
Q923Z6
O35664.2
M0R8H7
A8KAJ4
D3DSE8
D3DSE9
Q15467
Q6FHD7
O35238
O35663
O35983
Q923Z5

PIR ID I39073
S59501

GenBank ID NC_000021
NM_001289125
NP_001276054
NM_001289128
NP_001276057
NM_207585
NP_997468
NM_001289126
NP_001276055
NM_000874
NP_000865
NM_207584
NP_997467
NG_016003
AF039905
AH004970
AAB46417
AAB46418
AAB46419
AP000292
AP000293
AP000294
AP000295
AP001716
AY740397
AAU21038
CH471079
EAX09842
EAX09843
EAX09844
EAX09845
EAX09846
KF457225
AK293059
BAF85748
BC002793
AAH02793
BC013156
BG715143
BI520056
BM677386
CD110317
CR541817
CAG46616
HG380509
CDG37809
HY104613
L41942
AAB46413
L41943
AAB46414
L41944
AAB46415
U29584
AAC50202
X77722
CAA54785
X89772
CAA61914
X89814
CAA61940
P48551
NC_000082
NM_010509
NP_034639
NM_001110498
NP_001103968
XM_006522923
XP_006522986
XM_011246100
XP_011244402
XM_017316882
XP_017172371
NM_001347258
AC152503
AF367979
AAK73022
AAK73023
AAK73024
AF440786
AAL40944
AAL40945
CH466602
EDL03831
EDL03832
AF013274
AAC53351
AF013486
AAC53352
AK003185
BAB22628
AK010952
BAB27287
AK139169
BAE23909
AK150386
BAE29516
AK150597
BAE29690
AK151474
BAE30430
AK151493
BAE30446
AK151777
AK152878
BAE31563
AK153317
BAE31897
AK181436
AK195915
AK199902
AK201656
AK205320
AK209089
AK210331
AK212415
AK218073
AV351897
BC003743
AAH03743
BC071225
AAH71225
BE691178
BE993108
BX515017
Y09813
CAA70943
Y09864
CAA70991
Y09865
CAA70992
O35664
NC_005110
XM_006248107
XP_006248169
XM_017598091
XP_017453580
AC_000079
XM_006221074
XP_006221136
XM_017604280
XP_017459769
AABR07033629
AABR07033630
AAHX01068276
AAHX01068277
AAHX01068278
CH473989
EDM10714
L42323
AMYH02037734
AMYH02037733
AMYH02037735
ABM87259
XP_005261024
XP_005261023
XP_005261022
XP_005261025
AAHY01130185
AC_000038
XM_005260965
XM_005260967
XM_005260966
XM_005260968
AC_000153
L42240
L42241
L42242
L42243
NC_018932
L42237
L42238
L42239
DQ896260
ABBA01057336
ABBA01057335
ABBA01057334
ABM83941
DQ893015

Swiss-Prot ID INAR2_HUMAN
INAR2_MOUSE

Cell Localization Cell membrane
Secreted
Membrane
Plasma membrane

Ensembl ID ENSG00000159110
ENSG00000249624
ENSP00000384309.2
ENST00000404220.7
ENSP00000343957.4
ENST00000342136.8
ENSP00000343289.3
ENST00000342101.7
ENSP00000371699.3
ENST00000382264.7
ENSP00000496248.1
ENST00000646150.1
ENSMUSG00000022971
ENSMUSP00000113358.1
ENSMUST00000117836.7
ENSMUSP00000023693.7
ENSMUST00000023693.13
ENSMUSP00000086443.6
ENSMUST00000089042.6
ENSRNOG00000045668
ENSRNOP00000065773.2
ENSRNOT00000072856.2
ENSP00000343957
ENST00000382264
ENST00000382241
ENST00000404220
ENSRNOT00000072856
ENST00000342101
ENSMUST00000023693
ENSP00000384309
ENSMUSP00000023693
ENSMUSP00000113358
ENSMUST00000089042
ENSP00000371676
ENSP00000371699
ENSRNOP00000065773
ENSMUST00000117836
ENSMUSP00000086443
ENSP00000343289
ENST00000342136

MGI ID MGI:1098243
1098243

RGD ID 1583177

Unigene ID Mm.6834
Hs.708195

Homologene ID 49242

Shape Stick-vertex

IPI ID IPI00220690
IPI00395208
IPI00395209
IPI00220691
IPI00010193
IPI00312295