Protein TNFSF10

URN urn:agi-llid:8743
Total Entities 0
Connectivity 4117
Name TNFSF10
Description tumor necrosis factor (ligand) superfamily, member 10
Notes The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway Cortisol in Resolving Inflammation
Toll-like Receptors Act through MYD88-TIRAP Signaling
TLR4 Signaling in Leukocytes
Natural Killer Cell Activation
Peripheral T-Cell Tolerance
T-Cell Central Tolerance
T-Cell Cytotoxic Mediated Cell Death
Toll-like Receptors in Sterile Inflammation
Megakaryocyte -> Platelet Precursor Cell Surface Expression Markers
T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers
Myoblast -> Neutrophil Surface Expression Markers
Apoptosis
Proteins Involved in Atherosclerosis
Apoptosis of Myocyte
Proteins Involved in Melanoma
Dendritic Cells Function in Psoriasis
Proteins Involved in Systemic Lupus Erythematosus
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Colorectal Neoplasms
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Proteins Involved in Multiple Myeloma
Proteins Involved in Pancreatic Cancer
Apoptosis Block in Synovial Fibroblast
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in HIV Type 1 Infection
Neurofibrillary Tangle Formation
Proteins Involved in Glioblastoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Medulloblastoma
Proteins Involved in Neuroblastoma
Proteins Involved in Multiple Sclerosis
Breast Cancer
Proteins Involved in Prostate Cancer
CXCL12 Expression Targets
Clozapine Induced Granulocytopenia
EGF -> FOXO3A Expression Targets
Erythropoietin -> FOXO3A Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
IFNA1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL13 Expression Targets
IL15 Expression Targets
IL2 Expression Targets
Morphine Expression Targets
IFNA1/Gq Expression Targets
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNFSF10 Expression Targets
TNF -> AP-1 Expression Targets
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
TNFR -> NF-kB Signaling
TLR1 -> 2/6 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of bone mineral density
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of vascular reactivity
Neighbors of cancer incidence
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of antimetastatic activity
Neighbors of glucose level
Neighbors of radiosensitivity
Neighbors of pregnancy outcome
Neighbors of fertility
Neighbors of monocyte count
Neighbors of metabolic response
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of bone mineral density
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of vascular reactivity
Neighbors of cancer incidence
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of antimetastatic activity
Neighbors of glucose level
Neighbors of radiosensitivity
Neighbors of pregnancy outcome
Neighbors of fertility
Neighbors of monocyte count
Neighbors of metabolic response
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of neutrophil infiltration
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of neointima
Neighbors of vasculitis
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of coronary artery disease
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of microglia
Neighbors of trophoblast
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of activated T-cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of podocyte
Neighbors of antigen-presenting cell
Neighbors of phagocyte
Neighbors of lymphocyte
Neighbors of lymphoid cell
Neighbors of lung
Neighbors of liver
Neighbors of carotid artery
Neighbors of blood vessel wall
Neighbors of islets of Langerhans
Neighbors of lymphatic system
Neighbors of spleen
Neighbors of alveolus
Neighbors of hip region
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of growth factor
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of inflammatory cytokine
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of IL12
Neighbors of lectin
Neighbors of interleukin-35
Neighbors of proteasome endopeptidase complex
Neighbors of histone H3
Neighbors of WNT
Neighbors of PP2B
Neighbors of ITG
Neighbors of CD3 complex
Neighbors of histone
Neighbors of deacetylase
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
dsRNA induces innate immunity and INFs in alveolar cells
4_2_Genes with mutations currently associated with ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
2_HIV - induced depletion of CD4+ T-cells
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
drug-target moltransport

MedScan ID 8743

LocusLink ID 8743
22035
246775

Alias tumor necrosis factor-related apoptosis-inducing ligand
tumor necrosis factor superfamily member 10
TN10
TL2
Ly81
Tnfsf10
A330042I21Rik
A330042I21
TN10_HUMAN
GNB:1149558
tumor necrosis factor (ligand) family, member 10
trail/apo2l
CD253 antigen
TNF superfamily member 10
Tnlg6a
TRAIL
TNF-related apoptosis inducing ligand TRAIL
APO2L
APO-2Ls
tumor necrosis factor apoptosis-inducing ligand splice variant delta
RIKEN cDNA A330042I21 gene
antigen CD253
tumor necrosis factor (ligand) superfamily, member 10
CD253
AI448571
Apo-2 ligand
tumor necrosis factor ligand 6a
TNF-related apoptosis inducing ligand
chemokine tumor necrosis factor ligand superfamily member 10
Apo-2L
tumor necrosis factor ligand superfamily member 10
TNF-related apoptosis-inducing ligand
tumour necrosis factor (ligand) family, member 10
tumor necrosis factor (ligand) superfamily member 10
tumour necrosis factor apoptosis-inducing ligand splice variant delta
tumour necrosis factor superfamily member 10
tumour necrosis factor-related apoptosis-inducing ligand
chemokine tumour necrosis factor ligand superfamily member 10
tumour necrosis factor (ligand) superfamily, member 10

GO ID 0045569
0005125
0005102
0005164
0008270
0006919
0006915
0007166
0007267
0006955
0008584
1902042
0043123
0043065
0043280
2001238
0090200
1902041
0032868
0007165
0070062
0005576
0005887
0046872
0032813
0005615
0016021
0016020
0005886
0010469
0006917
0008633
0097296
2001239
0008624
0005515
0097190

KEGG ID hsa:8743
mmu:22035
rno:246775

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 3

OMIM ID 603598

Rat chromosome position 2q24

Hugo ID 11925
HGNC:11925

Human chromosome position 3q26.31
3q26

Swiss-Prot Accession P50591
Q6IBA9
P50591.1
P50592
Q3U5H0
P50592.1
E9PU84
A1Y9B3
Q8K3G0

GenBank ID NC_000003
NR_033994
NM_001190942
NP_001177871
NM_003810
NP_003801
NM_001190943
NP_001177872
AC007919
AC016938
AF178756
CH471052
EAW78465
EAW78466
EAW78467
CQ892411
CAH68809
CS276168
CAL33971
EF064708
ABK41891
HA637646
CAZ39545
JA362607
CCA94584
KT258720
AK296085
BAG58840
AK309200
AK312742
BAG35612
AY312579
AAR16184
BC009795
BC020220
BC032722
AAH32722
BT019564
AAV38371
CR456895
CAG33176
DA041872
DA969653
DQ848564
ABI24016
EU183231
ABW24658
LN874323
CTQ86088
U37518
AAC50332
U57059
AAB01233
P50591
NC_000069
NM_009425
NP_033451
AB052771
BAB19680
AC116585
AC157919
AF470537
AAM91908
CH466530
EDL34926
AK039433
AK142960
BAE25231
AK144931
AK153581
BAE32108
AK157633
BAE34141
BC011469
BC138807
AAI38808
BC138808
AAI38809
BY734631
LN874399
CTQ86164
U37522
AAC52345
P50592
NC_005101
XM_017590632
XP_017446121
XM_017590634
XP_017446123
XM_017590633
XP_017446122
NM_145681
NP_663714
AC_000070
AABR07009804
AABR07009805
AAHX01015916
AAHX01015917
AAHX01015918
CH473961
EDM01114
AY115578
AAM49797
EF030546
ABK32522
FQ225256
FQ234188
LN874413
CTQ86178
ABM81799
AAHY01024976
AAHY01024975
DQ890873
ABM84955
DQ894029
AC_000025
AABR06015456
AMYH02008147
AABR06015457
AABR06015458
ABBA01058648
AC_000135
NC_018914

Swiss-Prot ID TNF10_HUMAN
TNF10_MOUSE

Cell Localization Cell membrane
Secreted
Membrane
Extracellular

Ensembl ID ENSG00000121858
ENSP00000389931.2
ENST00000420541.6
ENSP00000241261.2
ENST00000241261.7
ENSMUSG00000039304
ENSMUSP00000040271.5
ENSMUST00000046383.11
ENSRNOG00000013269
ENSRNOP00000017758.5
ENSRNOT00000017758.5
ENST00000241261
ENSP00000389931
ENST00000420541
ENSRNOP00000017758
ENSRNOT00000017758
ENSP00000241261
ENST00000241261.6
ENSMUSP00000040271
ENSMUST00000046383

MGI ID MGI:107414
107414

RGD ID 628734

Unigene ID Mm.1062
Rn.83627
Rn.133346
Hs.478275

Homologene ID 2824

Shape Rhomb

IPI ID IPI00000049
IPI00119330
IPI00790933