URN | urn:agi-llid:3594 |
---|---|
Total Entities | 0 |
Connectivity | 418 |
Name | IL12RB1 |
Description | interleukin 12 receptor subunit beta 1 |
Notes | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
Pathway | CD8+ T-Cell Activation |
---|---|
Th1-Cell Differentiation | |
Th17-Cell Differentiation | |
Th1-Cells Activation and Proliferation in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Proteins Involved in Myocarditis | |
Atopic Dermatitis | |
T-Cells Differentiation Block in Psoriasis | |
Th17-Cell Function in Systemic Lupus Erythematosus | |
Th1-Cell Function in Systemic Lupus Erythematosus | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
Toll-like Receptors in beta-Cell | |
CD4+T-Cell Response in Celiac Disease | |
Th1-Cell Activation in Crohn's Disease | |
Th17-Cell Activation in Crohn's Disease | |
Follicular Lymphoma | |
Il17 Signaling Related Neutrophilia in Asthma | |
Th17-Cell Differentiation in Asthma | |
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis | |
Th17-Cell Numbers Reduction in HIV | |
IL23A and IL17A Provoke Cancer-Associated Inflammation | |
IL12R -> STAT Signaling | |
IL23R -> STAT3/NF-kB Signaling | |
IL12R -> NF-kB/NFATC Signaling | |
IL12B Expression Targets | |
PPAR Psoriasis | |
1_Differentiation of psoriatic T cells | |
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
Differentiation of psoriatic T cells |
MedScan ID | 3594 |
---|---|
171333 |
LocusLink ID | 3594 |
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16161 | |
171333 |
Alias | IL-12 receptor beta component |
---|---|
IL12RB | |
interleukin-12 receptor subunit beta-1 | |
LOC270057 | |
interleukin IL-12R-beta1 | |
IL-12 receptor subunit beta-1 | |
interleukin IL-12 receptor beta | |
interleukin IL-12 receptor beta component | |
IL-12R subunit beta-1 | |
IL-12R[b] | |
Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) | |
interleukin IL12rb I | |
Interleukin-12 receptor beta | |
IL-12 receptor beta | |
I12R | |
interleukin 12 receptor beta 1 subunit | |
IL12rb I | |
MGC34454 | |
IL12 receptor component | |
IL-12R(b) | |
interleukin IL-12R-beta I | |
interleukin IL12 receptor component | |
I12R_HUMAN | |
LOC234387 | |
IL-12R-beta1 | |
interleukin IL-12R(b) | |
CD212 antigen | |
IL12rb1 | |
interleukin IL12rb1 | |
interleukin IL12 receptor, beta 1 | |
antigen CD212 | |
interleukin IL-12R[b] | |
interleukin 12 receptor, beta 1 | |
CD212 | |
interleukin IL12RB | |
cluster of differentiation 212 | |
IL-12R-beta I | |
IMD30 | |
interleukin-12 receptor beta-1 chain | |
IL-12R-beta-1 | |
IL-12RB1 |
GO ID | 0019955 |
---|---|
0004896 | |
0016517 | |
0005143 | |
0042019 | |
0042020 | |
0071346 | |
0019221 | |
0035722 | |
0038155 | |
0001916 | |
0002827 | |
2000330 | |
2000318 | |
0042104 | |
0002230 | |
0032729 | |
0043382 | |
0007165 | |
0009897 | |
0042022 | |
0072536 | |
0005886 | |
0043235 | |
0018108 | |
0016021 | |
0016020 | |
0004872 |
KEGG ID | hsa:3594 |
---|---|
mmu:16161 | |
rno:171333 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 8 34.21 cM |
---|---|
8 33.5 cM |
OMIM ID | 601604 |
---|---|
614891 | |
209950 |
Rat chromosome position | 16p14 |
---|
Hugo ID | 5971 |
---|---|
HGNC:5971 |
Human chromosome position | 19p13.11 |
---|---|
19p13.1 |
Swiss-Prot Accession | P42701 |
---|---|
P42701.1 | |
Q60837 | |
A0A1D5RL98 | |
Q60837.2 | |
E9PSU7 | |
A8K308 | |
B2RPF1 | |
B7ZKK3 | |
Q8N6Q7 | |
Q3UV59 | |
Q3TAD0 | |
Q6PG56 |
PIR ID | I37892 |
---|---|
I49295 |
Swiss-Prot ID | I12R1_HUMAN |
---|---|
I12R1_MOUSE | |
Q3UV59_MOUSE |
Cell Localization | Membrane |
---|---|
Plasma membrane |
Ensembl ID | ENSG00000096996 |
---|---|
ENSP00000472165.2 | |
ENST00000593993.6 | |
ENSP00000314425.5 | |
ENST00000322153.11 | |
ENSMUSG00000000791 | |
ENSMUSP00000000808.7 | |
ENSMUST00000000808.7 | |
ENSMUSP00000148279.1 | |
ENSMUST00000212657.1 | |
ENSRNOG00000019216 | |
ENSRNOP00000025977.6 | |
ENSRNOT00000025977.6 | |
ENSP00000472165 | |
ENST00000593993 | |
ENSP00000314425 | |
ENST00000322153 | |
ENSMUSP00000000808 | |
ENSMUST00000000808 | |
ENSRNOP00000025977 | |
ENSRNOT00000025977 |
MGI ID | MGI:104579 |
---|---|
104579 |
RGD ID | 620025 |
---|
Unigene ID | Hs.567294 |
---|---|
Mm.731 | |
Rn.162266 | |
Rn.233637 |
Homologene ID | 4042 |
---|
Shape | Stick-vertex |
---|
IPI ID | IPI00121384 |
---|---|
IPI00001400 | |
IPI00218703 | |
IPI00297449 | |
IPI00877269 | |
IPI00795120 | |
IPI00461866 |