Protein TNF

URN urn:agi-llid:7124
Total Entities 0
Connectivity 30357
Name TNF
Description tumor necrosis factor
Notes This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway Longevity Related Drugs
Proteins with Altered Expression in Aging
Alzheimer's Disease
Osteoarthritis
Skin Aging
Androgen Deficiency in Male Obesity
MTHFR Activity Regulation
mTOR Signaling Hyperfunction
Prolactin Production
Somatostatin Receptors Signaling
Cortisol in Resolving Inflammation
Toll-like Receptors Act through MYD88-TIRAP Signaling
Antiviral Signaling through Pattern Recognition Receptors
DCIR1 (CLEC4A) Signaling
TLR4 Signaling in Leukocytes
Dectin-2 (CLEC6A)/Mincle (CLEC4E)/BDCA2 (CLEC4C) Signaling
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Peripheral T-Cell Tolerance
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Necrosis
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
MC1R in anti-Inflammatory Signaling
Lipoxins and Resolvins in Inflammation Resolution
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Leukotriene Effect on Vascular Endothelial Cell Response
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage Related Iron Uptake and Release
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
CCR1 Expression Targets
HTR5 -> TNF Production
TACR1 -> TNF/IL6/IL8 Production
IL1B Expression Targets -> Nociception
Monoblast -> Promonocyte Surface Expression Markers
Apoptosis
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
Dilated Cardiomyopathy
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Apoptosis of Myocyte
SOCS in Negative Feedback Regulation in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Proteins Involved in Vasospasm
Proteins Involved in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Mast-Cells Activation in Atopic Dermatitis
Proteins Involved in Atopic Dermatitis
Proteins Involved in Psoriasis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Dendritic Cells Function in Psoriasis
Proteins Involved in Photoaging
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Proteins Involved in Systemic Lupus Erythematosus
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Proteins Involved in Vitiligo
Oxidative Stress in Vitiligo
Genes with Mutations Associated with Vitiligo
Vitiligo
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 1
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Neuropathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Adipose Tissue Inflammation Provokes Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
Proteins Involved in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
Apoptosis of Thyroid Cell in Hashimoto's Thyroiditis
Proteins Involved in Graves Disease
Proteins Involved in Hypothyroidism
Thymic Follicular Hyperplasia
Fatty Acids in Hypertension and Atherosclerosis Development
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Proteins Involved in Celiac Disease
Proteins Involved in Colorectal Neoplasms
Crohn's Disease
Macrophage Dysfunction
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
Proteins Involved in Helicobacter Infections
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Proteins Involved in Antiphospholipid Syndrome
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
Hodgkin and Reed-Sternberg Cells in Hodgkin Lymphoma
Proteins Involved in Hodgkin Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Splenic Marginal Zone Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in Multiple Myeloma
TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
Proteins Involved in Thrombophilia
Proteins Involved in alpha 1-Antitrypsin Deficiency
Proteins Involved in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
TRPM7/8 in Pancreatic Adenocarcinoma
Goblet-Cell Related Mucus Secretion in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Proteins Involved in Cystic Fibrosis
Airway Epithelial Cell Dysfunction
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
Proteins Involved in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
Proteins Involved in Osteoarthritis
Proteins Involved in Polycystic Ovary Syndrome
Dendritic Cell Dysfunction in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
FAS Mediated Apoptosis in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
Proteins Involved in Dental Caries
Dentin and Enamel Dysruprion in Bloch-Sulzberger Syndrome
Proteins Involved in HIV Type 1 Infection
Apoptosis Block in Infected Cells
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
Proteins Involved in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
NF-kB Signaling Activation in Huntington Disease
Proteins Involved in Retinitis Pigmentosa
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
Gluten Impact on Neuronal System (Hypothesis)
beta-Casomorphins/Opioid Receptors Affect Brain Function (Hypothesis)
Muscular Dystrophies
Proteins with Altered Expression in Osteoarthritis
Proteins Involved in Osteoporosis
Bone Loss in Osteoporosis
Proteins with Altered Expression in Osteoporosis
Osteoclast Activation in Postmenopause
Bone Resorption by Osteoclasts in Osteoporosis
Genes with Mutations Associated with Psoriatic Arthritis
Proteins with Altered Expression in Psoriatic Arthritis
Proteins with Altered Expression in Rheumatoid Arthritis
Microglia Activation in Alzheimer's Disease
Proteins Involved in Alzheimer's Disease
Proteins Involved in Epilepsy
Ketogenic Diet Mechanism (Hypothesis)
HMGB1 and IL1B in Neuroinflammation
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Proteins Involved in Glioblastoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Migraine
Proteins Involved in Neuroblastoma
Microglia Activation in Parkinson's Disease
Proteins with Altered Expression in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Proteins with Altered Expression in Amyotrophic Lateral Sclerosis
Proteins Involved in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
Neuroinflammation in Amyotrophic Lateral Sclerosis
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
MBP/MOG/PLP in Immune System Activation
Proteins Involved in Multiple Sclerosis
Proteins Involved in Sleep Disorders
Proteins Involved in Vascular Dementia
Proteins Involved in Adhesion, Migration and Invasion of Endometriotic Cell
Proteins Involved in Endometriosis
Proteins with Altered Expression in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV Infection and Cancer
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Androgen Receptor/NKX3-1 Signaling
Androgen Receptor/Protein Kinase C-delta Signaling
Proteins Involved in Age-Related Macular Degeneration
OPTN Effects on NF-kB Signaling in Glaucoma
Proteins Involved in Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
Proteins Involved in Noise-Induced Hearing Loss
Proteins Involved in Presbycusis
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
Proteins Involved in Hearing Loss
Cochlear Inflammation (Noise-Induced)
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Immune System Role in Otitis Media
Genes with Mutations Associated with Asthma
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Epithelial Cell Apoptosis in COPD
Alveolar Macrophages Dysfunction in COPD
Glucocorticoid Resistance
Proteins Involved in Chronic Obstructive Pulmonary Disease
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Proteins Involved in Pulmonary Emphysema
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins Involved in Chronic Bronchitis
Proteins Involved in Polycystic Kidney Disease
Proteins Involved in Erectile Dysfunction
Proteins Involved in Glomerulonephritis
Proteins with Altered Expression in Glomerulonephritis
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
Proteins Involved in Pyelonephritis
Proteins with Altered Expression in Pyelonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
HMGB1 Expression Targets
S100B Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
Elevated Receptors -> Expression Targets in Adipose Tissue
GPCR Family -> Expression Targets in Adipose Tissue
GPCRs Family -> Expression Targets in Bone
CD2 Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD8 -> NF-kB Expression Targets
CD8 -> NFATC Expression Targets
CD8 -> STAT Expression Targets
CD80 -> AP-1 Expression Targets
CTF1 Expression Targets
CXCL12 Expression Targets
CCL16 Expression Targets
CCL5 Expression Targets
CCL2 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
GCG Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
NFKB Canonical Signaling Activation in Cancer
NFKB Non-Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
Proteins with Altered Expression in Tumor-Promoting Inflammation
NFKB Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
VEGFA Dependent Angiogenesis in Cancer
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
Proteins with Altered Expression in Cancer Metabolic Reprogramming
IDO1 in Cancer Immune Escape
Proteins with Altered Expression in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
HCAR1/HCAR2 -> MAPK Signaling
Fibronectin Expression Targets
IFNG/IFNR Expression Targets
IL7 Expression Targets
IL13 Expression Targets
IL21 Expression Targets
IL15 Expression Targets
IL16 -> AP-1 Expression Targets
IL3 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Thromboxane A2 Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymph Node
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
CD40 -> Expression Targets in Thymus
C5AR1 -> Expression Targets in Lymphoid System and Blood
IgE Receptors -> Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Thymus
P2RX7 -> Expression Targets in Nerve Tissue
Elevated Receptors -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
ADAM17 Expression Targets
Adenosine Expression Targets
NTS Expression Targets
POMC Expression Targets
AGT -> CREB Expression Targets
IFNA1/Gq Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
GAS6 -> AP-1/CREB Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
Collagen -> NF-kB Expression Targets
PAF Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
Elevated Receptors -> Expression Targets in Lung
TNF-alpha/TNFRSF1A Signaling
MERTK Signaling
Ras-GAP Regulation Signaling
AXL Receptor Tyrosine Kinase Signaling
NF-kB non-Canonical Signaling
TNF-alpha/TNFRSF1B Signaling
NF-kB Canonical Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NFAT Expression Targets
TCR -> AP-1 Expression Targets
TGFA -> STAT Expression Targets
TGFA -> FOXO3A Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB2-TGFBR1 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> STAT Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> STAT Expression Targets
TNF -> TP53/ATF Expression Targets
TNFRSF1A -> STAT Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
TNFR -> NF-kB Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
TLR3 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
IL1B -> NO Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
ROS in Triggering Vascular Inflammation
Elevated Receptors -> Expression Targets in Kidney
pathway 4
PPAR Psoriasis
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative regulators
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of aortic smooth muscle cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of carotid artery
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of lymphatic system
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of allantois
Neighbors of alveolus
Neighbors of coronary artery
Neighbors of left ventricle
Neighbors of uterine cervix
Neighbors of omentum
Neighbors of vein
Neighbors of villus
Neighbors of bronchus
Neighbors of glands
Neighbors of eye
Neighbors of cornea
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of lymph node of mesentery
Neighbors of mammary gland
Neighbors of vagina
Neighbors of ankle joint
Neighbors of thymus gland
Neighbors of cerebral cortex
Neighbors of brain blood vessel
Neighbors of myelin sheath
Neighbors of bladder
Neighbors of draining lymph node
Neighbors of nervous system
Neighbors of retina blood vessel
Neighbors of mesentery
Neighbors of nasopharynx
Neighbors of salivary gland
Neighbors of trachea
Neighbors of corpus luteum of ovary
Neighbors of sympathetic nervous system
Neighbors of nerve
Neighbors of ileum
Neighbors of endocrine system
Neighbors of lower extremity
Neighbors of small intestine
Neighbors of aggregated lymphoid follicle of small intestine
Neighbors of globus pallidus
Neighbors of amniotic cavity
Neighbors of lumbar spine
Neighbors of knee joint
Neighbors of pleura
Neighbors of left atrium
Neighbors of Fallopian tube
Neighbors of hypothalamus
Neighbors of hair follicle
Neighbors of artery wall
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of endothelin
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of alpha2 adrenoceptor
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of immunoglobulin
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of relaxin
Neighbors of TLR1/2 heterodimer
Neighbors of FSH
Neighbors of TORC1
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of histone acetyltransferase
Neighbors of adrenoceptor
Neighbors of phosphodiesterase
Neighbors of caspase
Neighbors of phosphoinositide phospholipase C
Neighbors of deacetylase
Neighbors of TLR4/Myd88
Neighbors of TNF-alpha receptor
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
PPARs and anxiety common targets
Amygdaloid expressed genes
PPARs and neuroinflamation
sars-cov no binding
New Pathway (4)
dsRNA induces innate immunity and INFs in alveolar cells
Dendritic Cell Activation in COVID19
Overview. Diseases of the skin (chapter 11)
Overview. Diseases of the digestive system (chapter 10)
Overview. Diseases of the nervous system (chapter 5)
Overview. Diseases of the eye (chapter 6)
Overview. Diseases of the respiratory (chapter 9)
Overview. Diseases of the genitourinary system (chapter 13)
Overview. Endocrine and metabolic diseases (chapter 4)
Overview. Infectious and parasitic diseases (chapter 2)
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
2_Podocyte dysfunction in glomerulonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
2_Cardiomyocyte hypertrophy
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
2_HIV - induced depletion of CD4+ T-cells
3_Impairment of iron release from splenic macrophages
5_The rationale for the treatment of anemia of chronic disease with erythropoietin
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
drug-target pairs binding
drug-target pairs direct regulation
drug-target moltransport
drug-target molsynthesis
New Combined Pathway
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atherosclerosis
Genes with Mutations Associated with Psoriasis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Vitiligo
Proteins Involved in Graves Ophthalmopathy
Genes with Mutations Associated with Obesity
Genes Associated with Ulcerative Colitis
Genes with Mutations Associated with Asthma
Genes with Mutations Associated with Psoriatic Arthritis
Genes with Mutations Associated with Systemic Scleroderma
Genes with Polymorphisms Associated with Migraine
Genes with Mutations Associated with Multiple Sclerosis
Genes with Mutations Associated with Endometriosis
other partners for SARS

MedScan ID 7124

LocusLink ID 7124
21926
24835
257601
257551

Alias TNF alfa
DADB-70P7.1
TNF superfamily, member 2
Tnlg1f
TNF, macrophage-derived
OTTHUMP00000037669
tumor necrotizing factor alpha
pre-tumor necrosis factor
MGC124630
pro-tumor necrosis factor
TNFA_HUMAN
TNFA
TNF-a
LOC257551
Tnfsf1a
tumor necrosis alpha
tumor necrosis factor alfa
tumor necrosis factor ligand superfamily member 2
TNFSF2
TNF-alpha
proTNF-alpha
tumor necrosis factor II
MGC151434
tumor necrosis factor 2
tumor necrosis factor
TNF
OTTHUMP00000029281
tumor necrosis factor superfamily member 2
tumor necrosis factor alpha
pro-TNF-alpha
RATTNF
protumour necrosis factor
cachectin
TNF superfamily, member II
TNF, monocyte-derived
protumor necrosis factor
TNF precursor
cachectin-tumor necrosis factor propeptide
tumor necrosis factor ligand 1f
APC1 gene
LOC257601
DIF
APC1 protein
tumor necrosis factor-alpha
TNFalpha
tumor necrosis factor (TNF superfamily, member 2)
tumour necrosis factor 2
tumour necrosis factor II
tumour necrosis factor ligand superfamily member 2
tumour necrosis factor superfamily member 2
cachectin-tumour necrosis factor propeptide
tumour necrosis factor
tumour necrosis factor alpha
tumour necrotizing factor alpha
pre-tumour necrosis factor
tumour necrosis factor alfa
tumour necrosis factor (TNF superfamily, member 2)
TNF alpha
tumor necrosis factor, alpha (cachectin)
tumor necrosis factor, alpha (cachetin)
tumour necrosis factor, alpha (cachectin)
tumour necrosis factor, alpha (cachetin)
tumor necrosis factor superfamily, member 2
tumor necrosis factor superfamily, member 2
tumor necrosis factor superfamily member 2
TNFSF2s
tumor necrosis factor, alpha
tnf superfamily
DASS-280D8.2
Tumor necrosis factor alpha (cachetin)
similar to tumor necrosis factor (tnf superfamily
similar to tumor necrosis factor (tnf superfamily, member 2)
alpha (cachetin)
tumor necrosis factor superfamily member II

GO ID 0005125
0002020
0044212
0005164
0007249
0007254
0000165
0000187
0000185
0006919
0048143
0071230
0071316
0071407
0002439
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0002740
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0043242
0000122
0045892
0045071
0030316
0051091
0070374
0043123
0046427
0043507
0043406
0051092
1901224
1902004
0043065
2000334
0060559
0070886
0045785
2000304
2000343
0045080
0032722
0090197
0002876
0043280
0001819
0050715
0031622
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0010628
0060252
0051798
0034116
0002925
0050729
0032729
0045410
0032755
2000778
0045416
0032757
1904999
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0051044
0071677
0150078
0043525
0045429
0051000
0051173
0045672
0033138
0050766
0014068
0071803
0043068
0045732
0031334
0043243
0051897
0045860
2000010
1903078
0001934
0051222
0048661
1901671
0050806
0045944
0045893
0045994
0042531
1904707
0060557
0043491
0072659
0032800
0043122
0060693
2000351
1903140
0045598
0051023
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0051966
0006357
0010803
0051384
0009651
0009615
0030730
0033209
0009986
0009897
0005576
0005615
0005887
0045121
0001891
0005886
0055037
0009887
0006915
0097190
0019722
0001775
0045123
0071222
0006952
0042742
0050966
0006955
0050900
0007275
0002037
0008285
0031642
0046330
0045760
0008284
0032741
0045840
0042127
0050727
0045670
0001932
0050708
2000377
0032496
0010033
0007165
0034138
0042311
0005737
0016021
0016020
0043025
0030141
0002526
1904646
0071300
0007623
2000353
2000866
0010469
0014823
0042493
1990268
0001666
0009612
0009314
0003009
0005622
0000060
0008283
0090002
0042346
0051533
0006927
0070265
0010940
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0060555
0043066
0006916
0008624
0010843
0016563
0016564
0032582
0043193
0010552
0042802
0016481
0045941
0005515
0007159
0005625
0009611
0006355
0006968
0004871
0050875
0007267

KEGG ID hsa:7124
mmu:21926
rno:24835

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2848815
2995927
3001529
3031624
3464978
3552045
3555974
3856324
3883195
3932069
6392892
7494249
7523444
7526541
7693046
7695626
7818827
7859743
7935762
8336080
8590321
8597870
8724035
8852605
9110146
9269771
9278385
9334723
9378998
9438495
9449720
9552007
9639071
9651389
9670843
9730685
9828130
10202016
10205166
14656967
15489334
16133992
16473522
16707968
16730227
16814297
16820934
16859780
16897113
16916598
16930761
16953332
16980557
16988194
17014432
17057944
17063315
17087739
17090647
17101499
17114809
17133355
17141882
17143972
17164537
17166738
17171665
17185628
17192953
17194482
17208210
17208287
17208993
17209781
17213876
17216494
17221211
17227768
17234183
17234379
17238853
17268200
17272816
17277048
17277102
17298451
17298885
17303559
17304101
17304103
17305696
17307728
17328044
17330135
17335072
17343250
17346438
17347550
17349210
17356374
17356550
17359518
17373637
17380115
17382880
17389591
17395331
17397790
17397798
17397847
17401435
17405915
17408448
17412556
17416344
17426528
17428673
17431682
17434489
17439892
17442953
17445540
17449468
17450233
17452160
17452460
17452777
17454170
17458901
17460948
17475896
17477779
17479109
17482757
17483581
17493155
17493863
17495957
17498265
17498268
17499233
17505301
17509552
17513605
17515611
17516296
17530646
17530706
17532302
17543146
17550423
17560079
17562931
17564320
17579071
17583675
17587429
17589947
17592115
17592300
17592954
17593951
17597660
17599062
17599736
17600229
17624216
17631138
17631734
17631742
17635596
17635597
17641010
17657677
17665457
17674321
17785317
1964681
2009860
2551905
2922050
8499947
9442056
9488135
10089307
10411942
10415052
10515827
10799877
10878371
10914503
11005868
11298355
12093867
12471131
12551985
12771125
12855817
12872135
14691292
14764707
15111301
15207270
16054986
16129814
16210607
16237096
16275384
16285964
16751399
16923852
16935850
16958667
17015619
17046971
17095513
17098824
17101148
17107717
17123788
17151142
17171644
17198884
17202326
17203472
17210619
17218256
17222972
17228359
17229673
17234424
17236235
17237440
17242187
17266742
17276429
17277081
17301687
17301950
17304113
17307724
17336618
17341609
17353445
17360740
17361131
17372191
17379643
17380205
17384464
17391979
17395890
17409491
17416608
17416740
17416966
17428547
17436232
17438029
17449582
17451964
17464333
17467668
17467814
17475837
17482668
17485113
17485464
17485824
17487773
17500068
17512902
17513720
17513784
17517868
17537727
17543594
17548042
17572011
17576366
17579033
17591872
17606866
17618911
17638882
17640882
17692539
17713535
2268312
2777790
3349526
8039702
9551933
9874572
15060004
15935297
16705482
17158358
17161388
17166735
17170233
17170234
17278014
17336456
17337591
17346684
17380194
17405916
17416605
17433709
17531209
17582939
17592532
17659374

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 17 18.59 cM
17 19.06 cM

OMIM ID 191160
600807
157300
611162
248310

Rat chromosome position 20p12

Hugo ID 11892
HGNC:11892

Human chromosome position 6p21.33
6p21.3

Swiss-Prot Accession P01375
Q5STB3
P01375.1
A0A0R4J210
P06804
Q3U593
P06804.2
P16599
P16599.1
O43647
Q9P1Q2
Q9UIV3
O35853
Q62326
Q91VF3
Q6EE11
Q9JI26
Q9JI27
C1K3N5
Q5RT83
Q9UBM5
Q0X0E6
Q3U4I6
Q6TDG3
TNFA_HUMAN
TNFA_MOUSE
TNFA_RAT
Q5STB3_HUMAN
Q3U593_MOUSE

PIR ID A93585
A22908
JU0029

GenBank ID NC_000006
NM_000594
NP_000585
NT_167244
NT_113891
NT_167245
NT_167246
NT_167247
NT_167248
NT_167249
NG_007462
AB088112
BAC54944
AB103618
BAF31279
AB202113
BAE78639
AF129756
AAD18091
AJ249755
AJ270944
CAB65595
AL662801
AL662847
AL929587
AY066019
AAL47581
AY214167
AAO21132
AY274889
AY274890
AY274891
AY274892
AY274893
AY274894
AY274895
AY274896
AY274897
AY274898
AY274899
AY274900
AY274901
AY274902
AY799806
AAV63951
BA000025
BAB63396
BX248519
BX927320
CH471081
EAX03424
CR753892
CR759886
CR942185
CS081473
CAI95946
EF471114
EF471115
EF540585
EF540586
EU338455
KF887965
AHJ25918
KF887966
AHJ25919
KF887967
AHJ25920
KF887968
AHJ25921
KF887969
AHJ25922
KF887970
AHJ25923
KF887971
AHJ25924
KF887972
AHJ25925
KF934400
KF934401
KP339511
KP339512
AKI85808
KX953765
KY500676
AQY77148
KY500677
AQY77149
KY500678
AQY77150
LT546440
M16441
AAA61200
M26331
AAA36758
MH287061
QAY29141
U42625
AAB01765
X02910
CAA26669
Y14768
CAA75070
Z15026
CAA78745
AB451492
BAG70306
AF043342
AAC03542
AF098751
AAF71992
AJ227911
AJ251878
CAB63904
AJ251879
CAB63905
AK314960
BAG37464
BC028148
AAH28148
BI908079
BP215875
CA306559
FJ795028
ACO37640
HQ201306
ADV31546
LN874317
CTQ86082
M10988
AAA61198
X01394
CAA25650
P01375
NC_000083
NM_001278601
NP_001265530
NM_013693
NP_038721
NT_039662
NT_187027
NT_187004
AB039224
BAB68748
AB039226
BAB68750
AB039227
BAB68751
AB039228
BAB68752
AB039229
BAB68753
AB039230
BAB68754
AB039231
BAB68755
AB039232
BAB68756
AB062426
BAB78397
AB185894
BAF02298
AB185895
BAF02299
AB185896
BAF02300
AF109719
AAC82484
CH466666
EDL26631
EDL26632
CR974444
CU407309
CU466548
D84196
BAA19512
D84199
BAA19513
L22359
L22360
L22361
L22362
L22363
L22364
L22365
M20155
AAA40462
M38296
AAA40459
U06950
AAA18594
U68414
AAB65593
Y00467
CAA68530
AK153319
BAE31899
AK153800
BAE32187
AK154223
BAE32445
AK155964
BAE33525
AY423855
AAR00346
BC117057
AAI17058
BC137720
AAI37721
BY167004
LN874395
CTQ86160
M11731
AAA40458
M13049
AAA40457
X02611
CAA26457
P06804
NC_005119
NM_012675
NP_036807
AC_000088
AAHX01099608
AC094348
AF329982
AAK53568
AF329983
AAK53569
AF329984
AAK53570
AF329985
AAK53571
AF329986
AAK53572
AF329987
AAK53573
AY427673
AAR91624
AY427674
AAR91625
AY427675
AAR91626
BX883046
CAE84003
CH474121
EDL83547
EDL83548
D00475
BAA00367
L00981
AAA16275
L19123
AAA42255
AF269159
AAF82567
AF269160
AAF82568
AJ002278
CAA05290
BC107671
AAI07672
X66539
CAA47146
P16599
NC_018917
AMYH02013452
DQ891662
ABM82588
DQ894849
ABM85775
M35592
AAC42098
AC_000039
AAHY01132219
AC_000138
ABBA01038081
AB039225
BAB68749
AABR06099883
CAI18649
CAI41940
CAQ09993
CAQ06935
CAQ07711
NT_007592
NW_001838980
NW_923073
NG_012010
AC_000049
CAI18292
CAI17678
Q5RT83
Q5STB3
Q9UBM5
NT_039649
NW_001030616
Q0X0E6
Q3U4I6
Q3U593
Q6TDG3
NW_001084782
NW_047597
NT_113894
CH473975
EDL95526
NW_000124
135938
14091045
14091047
14091049
14091051
14091053
14091055
205254
220921
2570070
310232
395370
40795923
40795925
40795927
46237626
78070805
81886213
9049959
9049961
Q6EE11
109734296
111036530
111036532
111036534
123784221
123796047
123796993
135935
15823194
15823196
15823198
15823200
15823202
15823204
15823206
15823208
15823210
1944348
1944350
202083
202085
202087
202093
2304957
37695630
3941741
495468
54832
54845
74142271
74149062
74178356
74215095
81870785
114306801
119623829
123996347
135934
15277268
17978883
20381342
209486
27544420
27802685
2905634
339738
339741
339764
37210
37212
37220
3805811
4337115
55740339
55961541
55961700
56207432
57209823
6624926
6624928
66348790
6688232
74720074
74727307
74756060
8090602
86197995
123981518
148694684
148694685
149028096
149028097

Swiss-Prot ID TNFA_HUMAN
TNFA_MOUSE
TNFA_RAT
Q5STB3_HUMAN
C1K3N5_HUMAN
Q3U593_MOUSE

Cell Localization Cell membrane
Membrane
Secreted
Extracellular

Ensembl ID ENSG00000232810
ENSP00000398698.2
ENST00000449264.3
ENSMUSG00000024401
ENSMUSP00000126122.1
ENSMUST00000167924.1
ENSMUSP00000025263.8
ENSMUST00000025263.14
ENSRNOG00000055156
ENSRNOP00000074520.1
ENSRNOT00000079677.1
ENST00000449264.2
ENSP00000398698
ENST00000449264
ENSMUSP00000126122
ENSMUST00000167924
ENSMUSP00000025263
ENSMUST00000025263
ENSRNOG00000000837
ENSRNOP00000074520
ENSRNOT00000079677
ENSRNOT00000001110
ENSRNOP00000001110

MGI ID MGI:104798
104798

RGD ID 3876

Unigene ID Rn.2275
Mm.1293
Hs.241570

Homologene ID 496

Shape Rhomb

IPI ID IPI00128861
IPI00001671
IPI00213948
IPI00894294

Homo sapiens Chromosome position 6p21.3
6

Ensembl Transcript ID ENST00000383302
ENST00000383496
ENST00000376122

FunctionalClass cytokine
tumor necrosis factor receptor binding
protein binding

Mus musculus Chromosome position 17 19.06 cM

KEGG pathway Hematopoietic cell lineage
Type II diabetes mellitus
Type I diabetes mellitus
Apoptosis
Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
MAPK signaling pathway
TGF-beta signaling pathway
T cell receptor signaling pathway
Adipocytokine signaling pathway
Fc epsilon RI signaling pathway
Natural killer cell mediated cytotoxicity

Rattus norvegicus Chromosome position 20p12

Ensembl Gene ID ENSG00000206328
ENSG00000206439
ENSG00000204490

LocatorString pmquery:prevacid, prilosec (omeprazole) 2002:2010[PDAT]
digtext:C:\Users\Ariadne\Customers\Elan\Elan weekly report from literature condensed.txt
pmquery:sepsis+OR+blood+poisoning+OR+Septicemia+OR+systemic+inflammatory+response+syndrome
pmquery:curcumin prostate cancer