Protein IL12RB2

URN urn:agi-llid:3595
Total Entities 0
Connectivity 478
Name IL12RB2
Description interleukin 12 receptor, beta 2
Notes The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway CD8+ T-Cell Activation
Th1-Cell Differentiation
Th17-Cell Differentiation
T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Follicular Lymphoma
Il17 Signaling Related Neutrophilia in Asthma
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
IL12R -> STAT Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL12B Expression Targets
CD40 -> Expression Targets in Thymus
PPAR Psoriasis
1_Differentiation of psoriatic T cells
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
Differentiation of psoriatic T cells

Group Genes Frequently Hypermethylated in Follicular Lymphoma

MedScan ID 3595

LocusLink ID 3595
16162
171334

Alias interleukin IL-12 receptor beta 2
interleukin 12 receptor, beta II
interleukin-12 receptor subunit beta-2
IL12rb2
IL-12 receptor beta II
interleukin IL12rb2
OTTHUMP00000010662
Ifnm
interleukin 12 receptor beta 2 subunit
interleukin IL-12 receptor beta II
IL-12 receptor beta 2
IL-12R subunit beta-2
interferon response to microorganisms
RP11-102M16.1
A930027I18Rik
A930027I18
IL-12 receptor subunit beta-2
RIKEN cDNA A930027I18 gene
I12S_HUMAN
interleukin 12 receptor, beta 2
interleukin IL-12R-beta2
IL-12R-beta2
interleukin-12 receptor beta-2 chain
IL-12RB2
IL-12R-beta-2

GO ID 0019955
0004896
0019901
0007166
0032609
0035722
0070757
0018108
0008284
0032729
0032496
0009897
0005887
0005886
0043235
0034097
0016021
0016020
0019221
0045622
0004872
0007165

KEGG ID hsa:3595
mmu:16162
rno:171334

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 6 30.81 cM
6 30.1 cM

OMIM ID 601642

Rat chromosome position 4q31

Hugo ID 5972
HGNC:5972

Human chromosome position 1p31.3
1p31.3-p31.2

Swiss-Prot Accession B4DGA4
Q99665
A0A0A0MTN7
B7ZB60
Q99665.1
D3Z6H5
P97378
P97378.1
F1LRH7
B1AN98
B7ZKL9
F5H7L6
Q2M3V3
B9EHD9
Q9Z0Z1

GenBank ID NC_000001
NR_047584
NR_047583
XM_005270825
XP_005270882
XM_011541384
XP_011539686
XM_006710617
XP_006710680
XM_005270827
XP_005270884
XM_017001203
XP_016856692
XM_005270828
XP_005270885
XM_017001204
XP_016856693
NM_001258214
NP_001245143
NM_001319233
NP_001306162
NM_001559
NP_001550
NM_001258216
NP_001245145
NM_001258215
NP_001245144
XM_011541383
XP_011539685
NG_032977
AF349574
AL358512
AL389925
AY640177
AAT45456
CH471059
EAX06499
EAX06500
AK294494
BAG57715
AK300020
BAG61833
AK310837
AK316525
BAH14896
BC104772
AAI04773
BC104774
AAI04775
BC143248
BC143249
AAI43250
BC143250
BC143252
DA223630
DB126833
U64198
AAB36675
Q99665
NC_000072
XM_006505617
XP_006505680
NM_008354
NP_032380
NM_001311141
NP_001298070
AC130822
CH466523
EDK98805
AK040072
BC137745
AAI37746
U64199
AAB36676
P97378
NC_005103
XM_006236614
XP_006236676
XM_006236613
XP_006236675
NM_001191750
NP_001178679
XM_008762975
XP_008761197
XM_008762974
XP_008761196
XM_017592423
XP_017447912
AC_000072
AABR07060865
AAHX01030712
AAHX01030713
AAHX01030714
CH474042
EDL91574
DQ399740
DQ399741
DQ399742
AF083329
AAD16040
XM_011541385
XP_011539687
NC_018912
AMYH02001201
AMYH02001202
AMYH02001203
AMYH02001204
AMYH02001205
XM_011241226
XP_011239528
AC_000028
AAHY01053978
AAHY01053979
AAHY01053980
AAHY01053981
AAHY01053982
AAHY01053983
AAHY01053984
AAHY01053985
AC_000133
ABBA01074518
ABBA01074519
CAH69960
CAH70407
CAH70409
NT_032977
NW_921351
NW_001838579
AC_000044
NT_039353
NW_001030811
XM_231873
XP_231873
NW_047693
NW_001084829
XM_001067506
XP_001067506
Q9Z0Z1

Swiss-Prot ID I12R2_HUMAN
I12R2_MOUSE
B1AN98_HUMAN
B9EHD9_MOUSE

Cell Localization Membrane
Plasma membrane

Ensembl ID ENSG00000081985
ENSP00000360039.1
ENST00000371000.5
ENSP00000442443.1
ENST00000544434.5
ENSP00000445276.2
ENST00000541374.5
ENSP00000262345.1
ENST00000262345.5
ENSP00000497959.1
ENST00000648487.1
ENSMUSG00000018341
ENSMUSP00000113267.1
ENSMUST00000117441.7
ENSMUSP00000010605.3
ENSMUST00000018485.3
ENSRNOG00000007270
ENSRNOP00000009883.5
ENSRNOT00000009883.6
ENSP00000360039
ENST00000371000
ENSP00000442443
ENST00000544434
ENSP00000445276
ENST00000541374
ENSP00000262345
ENST00000262345
ENSMUSP00000010605
ENSMUST00000018485
ENSMUSP00000113267
ENSMUST00000117441
ENSRNOP00000009883
ENSRNOT00000009883

MGI ID MGI:1270861
1270861

RGD ID 620026

Unigene ID Hs.479347
Rn.207395
Mm.188337

Homologene ID 1197

Shape Stick-vertex

IPI ID IPI00438855
IPI00438856
IPI00124243
IPI00479253
IPI00881142
IPI00358054