Protein RIPK2

URN urn:agi-llid:8767
Total Entities 0
Connectivity 956
Name RIPK2
Description receptor interacting serine/threonine kinase 2
Notes This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway NOD-like Receptors
Crohn's Disease
Paneth-Cell Function in Crohn's Disease
Macrophage Dysfunction
Dendritic Cell Dysfunction in Crohn's disease
CagA Phosphorylation Independent Signaling
Dendritic Cell Function in Ulcerative Colitis
Blau Syndrome
Proteins Involved in Huntington Disease
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Autophagy dysfunction in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
mapk1 protein modificators

MedScan ID 8767

LocusLink ID 8767
192656
362491

Alias CARDIAK,CCK,RICK,RIP
RIKEN cDNA 2210420D18 gene
receptor interacting protein 2
receptor interactive protein II
receptor-interactive serine-threonine kinase 2
RIP-like-interacting CLARP kinase
DNA segment, Chr 4, Brigham & Women's Genetics 0615 expressed
RP23-378L22.1
CARD-containing IL-1 beta ICE-kinase
receptor (TNFRSF)-interactive serine-threonine kinase 2
CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
tyrosine-protein kinase RIPK2
CARD3
2210420D18Rik
growth-inhibiting gene 30
GIG30
receptor-interacting serine-threonine kinase 2
RICK
OTTMUSP00000004983
CARD-carrying kinase
CARDIAKs
WUGSC:H_RG437L15.1
receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
D4Bwg0615e
CARDIAK
receptor (TNFRSF)-interacting serine-threonine kinase II
receptor-interactive serine-threonine kinase II
(CARD)-containing serine/threonine kinase Rip2
receptor (TNFRSF)-interacting serine-threonine kinase 2
receptor interacting protein II
receptor (TNFRSF)-interactive serine-threonine kinase II
receptor interactive protein 2
CARD-containing interleukin-1 beta-converting enzyme-associated kinase
2210420D18
RIP serine threonine kinase 2
RIPK2
RIP2
receptor-interacting serine-threonine kinase II
CCK
RIP-2
receptor-interacting protein 2
receptor-interacting serine/threonine-protein kinase 2

EC Number 2.7.10.2
2.7.11.1

GO ID 0005524
0050700
0004706
0030274
0089720
0004715
0042803
0004674
0005102
0007249
0007254
0000165
0042098
0050852
0007256
0007257
0000187
0097202
0002250
0006915
0071223
0071225
0071224
0050830
0006954
0045087
0070498
0031663
0043066
0070427
0070431
0070423
0018108
0070374
0043123
0051092
0045627
0046641
0043065
0010942
0032722
0001961
0033091
0032727
0032728
0032729
0050718
0032735
0032743
0032755
0033138
0010800
0050731
0032092
0031398
0045944
0032760
1904417
0043330
0070671
0070673
0007165
0034134
0034142
0005737
0005856
0005829
0032991
0031982
0016301
0000166
0004672
0016740
0071222
0002376
0016310
0046330
0002827
0032874
0006468
0042981
0043281
0070555
0004871
0043234
0002755
0002756
0035666
0008063
0048011
0035872
0051403
0034130
0034138
0002224
0016772
0005622
0006916
0004872
0034166
0034146
0034162
0038123
0038124

KEGG ID hsa:8767
mmu:192656
rno:362491

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 4 6.7 cM
4 5.4 cM

OMIM ID 603455

Rat chromosome position 5q13

Hugo ID 10020
HGNC:10020

Human chromosome position 8q21.3
8q21

Swiss-Prot Accession A0A0S2Z4Z8
O43353
O43353.2
P58801
Q547H1
P58801.1
G3V783
B7Z748
Q6UWF0
Q2TU65
Q6Q322
Q3B7U0

GenBank ID NC_000008
XM_005251092
XP_005251149
NM_003821
NP_003812
XM_011517357
XP_011515659
NG_033016
AC004003
AAC24561
AF117829
CH471060
EAW91655
EAW91656
KC877257
AF027706
AAC34970
AF064824
AAC25668
AF078530
AAC27722
AI824070
AK075213
BAG52085
AK301448
BAH13484
AY358813
AAQ89172
AY358814
AAQ89173
AY524045
AAS94254
AY562996
AAS75586
BC004553
AAH04553
DA040898
KU178437
ALQ33895
KU178438
ALQ33896
O43353
NC_000070
XM_006537677
XP_006537740
XM_006537679
XP_006537742
XR_390315
XM_006537678
XP_006537741
NM_138952
NP_620402
NM_001329751
NR_138102
AL807379
CH466538
EDL05589
EDL05590
AF461040
AAL96436
AF487539
AAM76919
AK159593
BAE35213
AK172319
BAE42942
AK172417
BAE42997
AK192973
AK217339
BC050845
BC058088
BC069878
AAH69878
P58801
NC_005104
XM_017593470
XP_017448959
NM_001191865
NP_001178794
AC_000073
AABR07047366
AAHX01035130
AAHX01035131
CH473962
EDL98485
BC107468
AAI07469
FQ230093
NC_018919
AMYH02018389
AC_000026
AAHY01033792
AAHY01033793
AAHY01033794
BC025611
AAH25611
AC_000140
CAM22557
NT_008046
NW_001839136
NW_923984
AC_000051
CR592019
CR596906
Q2TU65
Q6Q322
NT_039258
NW_001030740
Q547H1
XM_342810
XP_342811
NW_047711
NW_001084836
XM_001056736
XP_001056736
Q3B7U0
ABBA01037399
ABBA01037400

Swiss-Prot ID RIPK2_HUMAN
RIPK2_MOUSE
Q547H1_MOUSE

Cell Localization Cytoplasm

Ensembl ID ENSG00000104312
ENSP00000220751.4
ENST00000220751.5
ENSMUSG00000041135
ENSMUSP00000038833.5
ENSMUST00000037035.11
ENSMUST00000183871.1
ENSRNOG00000009389
ENSRNOP00000012963.2
ENSRNOT00000012963.5
ENSP00000220751
ENST00000220751
ENSMUSP00000038833
ENSMUST00000037035
ENSMUST00000183871
ENSRNOP00000012963
ENSRNOT00000012963

MGI ID MGI:1891456
1891456

RGD ID 1309167

Unigene ID Hs.103755
Mm.112765
Rn.102179

Homologene ID 37856

Shape Sickle-vertex

IPI ID IPI00139382
IPI00021917
IPI00554774
IPI00816174
IPI00207880
IPI00766118