Pathway
|
Osteoarthritis
|
|
Cortisol in Resolving Inflammation
|
|
Immunoglobulin Class-Switch Recombination Activation
|
|
Treg-Cell Differentiation
|
|
AHR Signaling in Treg and Dendritic Cells Function
|
|
AHR Signaling in Th17 Cells Function
|
|
Th17-Cell Differentiation
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Vascular Smooth Muscle Cell/Pericyte Differentiation and Proliferation
|
|
PRL Expression Regulation by BMP4 and TGFB1
|
|
Activin, Inhibin and Follistatin Action on Pituitary Gland
|
|
G1/S Damage Checkpoint
|
|
Cell Cycle Overiew
|
|
Cardiomyocyte Dysfunction
|
|
Dilated Cardiomyopathy
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Proteins Involved in Arterial Hypertension
|
|
Proteins Involved in Pulmonary Hypertension
|
|
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension
|
|
BMP2 and Non-Canonical WNT Signaling in Pulmonary Artery Endothelial Cells
|
|
Endothelial Cell Dysfunction in Pulmonary Hypertension
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
Androgens in Sebocyte Maturation
|
|
Androgens Promote Scalp Dermal Papilla Regression
|
|
T-Cells Differentiation Block in Psoriasis
|
|
TGF-beta Signaling in Skin Aging
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Proteins Involved in Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
NKX2-1 in Thyroid Dysgenesis (Hypothesis)
|
|
GLIS3 Targets in Thyroid Dysgenesis (Hypothesis)
|
|
PAX8 Targets in Thyroid Dysgenesis (Hypothesis)
|
|
Proteins Involved in Obesity
|
|
Prolactinoma Overiew
|
|
Metastatic Colorectal Cancer
|
|
GUCY2C Signaling in Colorectal Cancer
|
|
Peutz-Jeghers Syndrome
|
|
Chronic Myeloid Leukemia
|
|
Vascularization in Hepatocellular Carcinoma
|
|
NOTCH Signaling in Hepatocellular Carcinoma
|
|
Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Pancreatic Ductal Carcinoma
|
|
Pancreatic Neuroendocrine Tumors
|
|
STK11 Signaling in Pancreatic Neoplasms
|
|
TGFBR Signaling in Pancreatic Neoplasms
|
|
Th17-Cell Differentiation in Asthma
|
|
Osteoblast Function Decline in Gout
|
|
Proteins Involved in Osteoarthritis
|
|
TGFB2 Signaling Impairement in Osteoarthritis
|
|
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
|
|
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
|
|
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
Th17-Cell Numbers Reduction in HIV
|
|
Hereditary Hemorrhagic Telangiectasia
|
|
Myostatin in Skeletal Muscles in Muscular Dystrophies
|
|
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
|
|
Genes with Mutations Associated with Osteoarthritis
|
|
Bone Loss in Osteoporosis
|
|
Hyperparathyroidism, Secondary Effect
|
|
Glioma Stem Cell Program Activation
|
|
Medulloblastoma
|
|
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to NOTCH Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
|
|
Breast Cancer
|
|
NOTCH1 Signaling in Breast Cancer
|
|
Proteins Involved in Female Infertility
|
|
Ovarian Cancer
|
|
INHA Gene Mutations in Granulosa Cell Proliferation
|
|
FSH Hyperproduction Due to INHA Mutation in Primary Ovarian Insufficiency
|
|
BMP Signaling Impairment in Granulosa Cell in POF
|
|
Prostate Cancer
|
|
Cytokines Trigger Otitis Media
|
|
Proteins Involved in Pulmonary Emphysema
|
|
Podocyte Dysfunction in Glomerulonephritis
|
|
Mesangial Cell Dysfunction in Glomerulonephritis
|
|
Interstitial Fibroblasts in Pyelonephritis
|
|
BMP6/ACVR2A Expression Targets
|
|
BMP7/ACVR2 Expression Targets
|
|
Elevated Receptors -> Expression Targets in Bone
|
|
Dexamethasone Induced Osteoporosis
|
|
EGF -> CTNN Expression Targets
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> STAT Expression Targets
|
|
FGF2 -> STAT Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
|
|
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
|
|
DNA Damage Checkpoint Impairment in Cancer
|
|
IL23A and IL17A Provoke Cancer-Associated Inflammation
|
|
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
|
|
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
|
|
HIF1A in Vasculogenic Mimicry of Cancer
|
|
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
|
|
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
|
|
Skeletal Muscle Wasting in Cancer Cachexia
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
INHBB/ACVR2 Expression Target
|
|
INHBA/ACVR2/ACVR1 Expression Targets
|
|
NOTCH -> Expression Targets in Skin
|
|
NOTCH -> Expression Targets in Thymus
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
NOTCH -> SMAD3 Signaling
|
|
ADAM17 Expression Targets
|
|
NOTCH Expression Targets
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
TGFBR/BMPR -> SMAD2/3 Signaling
|
|
ActivinR -> SMAD2/3 Signaling
|
|
TGFBR -> MEF/MYOD/MYOG Signaling
|
|
TGFBR1/AP-1 Signaling
|
|
MSTN/ACVR2/ACVR1 Expression Targets
|
|
NODAL/ACVR2B Expression Targets
|
|
NOTCH Receptors -> Receptors Expression Targets in Lung
|
|
JNK/MAPK Signaling
|
|
TGF-beta Signaling
|
|
TGFB2-TGFBR1 Expression Targets
|
|
TGFB3-TGFBR1 Expression Targets
|
|
TGFB1-TGFBR1 Expression Targets
|
|
TGFB1-TGFBR1/AP-1 Expression Targets
|
|
TGFB1-ACVRL1 Expression Targets
|
|
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
|
|
n
|
|
New Pathway (2)
|
|
PPAR Psoriasis
|
|
prarg negative regulators, ps-positive
|
|
pprarg neg, uknown targets, ps-positive
|
|
prarg neg,ukn expres targets, ps-positive
|
|
PPARG negative regulators
|
|
PPARG negative targets
|
|
pparg expr target_regulators
|
|
Neighbors of disease exacerbation
|
|
Neighbors of tumor progression
|
|
Neighbors of cancer progression
|
|
Neighbors of overall survival
|
|
Neighbors of disease severity
|
|
Neighbors of mortality
|
|
Neighbors of survival rate
|
|
Neighbors of infarct size
|
|
Neighbors of survival time
|
|
Neighbors of insulin sensitivity
|
|
Neighbors of clinical stage
|
|
Neighbors of lethality
|
|
Neighbors of recurrence-free survival
|
|
Neighbors of disease-free survival
|
|
Neighbors of tumor response
|
|
Neighbors of macrophage count
|
|
Neighbors of bone mass
|
|
Neighbors of body weight
|
|
Neighbors of body weight gain
|
|
Neighbors of cardiovascular risk
|
|
Neighbors of microvessel density
|
|
Neighbors of tumor promotion
|
|
Neighbors of neutrophil count
|
|
Neighbors of glucose tolerance
|
|
Neighbors of fibrosis progression
|
|
Neighbors of mortality rate
|
|
Neighbors of bone mineral density
|
|
Neighbors of adverse outcome
|
|
Neighbors of cell density
|
|
Neighbors of apoptosis rate
|
|
Neighbors of blood pressure
|
|
Neighbors of vascular reactivity
|
|
Neighbors of muscle mass
|
|
Neighbors of cancer risk
|
|
Neighbors of systolic blood pressure
|
|
Neighbors of tumor resistance
|
|
Neighbors of blood glucose
|
|
Neighbors of renal hypertrophy
|
|
Neighbors of energy expenditure
|
|
Neighbors of radiosensitivity
|
|
Neighbors of left ventricular ejection fraction
|
|
Neighbors of fertility
|
|
Neighbors of lymphocyte count
|
|
Neighbors of insulin level
|
|
Neighbors of fibroblast phenotype
|
|
Neighbors of disease exacerbation
|
|
Neighbors of tumor progression
|
|
Neighbors of cancer progression
|
|
Neighbors of overall survival
|
|
Neighbors of disease severity
|
|
Neighbors of mortality
|
|
Neighbors of survival rate
|
|
Neighbors of infarct size
|
|
Neighbors of survival time
|
|
Neighbors of insulin sensitivity
|
|
Neighbors of clinical stage
|
|
Neighbors of lethality
|
|
Neighbors of recurrence-free survival
|
|
Neighbors of disease-free survival
|
|
Neighbors of tumor response
|
|
Neighbors of macrophage count
|
|
Neighbors of bone mass
|
|
Neighbors of body weight
|
|
Neighbors of body weight gain
|
|
Neighbors of cardiovascular risk
|
|
Neighbors of microvessel density
|
|
Neighbors of tumor promotion
|
|
Neighbors of neutrophil count
|
|
Neighbors of glucose tolerance
|
|
Neighbors of fibrosis progression
|
|
Neighbors of mortality rate
|
|
Neighbors of bone mineral density
|
|
Neighbors of adverse outcome
|
|
Neighbors of cell density
|
|
Neighbors of apoptosis rate
|
|
Neighbors of blood pressure
|
|
Neighbors of vascular reactivity
|
|
Neighbors of muscle mass
|
|
Neighbors of cancer risk
|
|
Neighbors of systolic blood pressure
|
|
Neighbors of tumor resistance
|
|
Neighbors of blood glucose
|
|
Neighbors of renal hypertrophy
|
|
Neighbors of energy expenditure
|
|
Neighbors of radiosensitivity
|
|
Neighbors of left ventricular ejection fraction
|
|
Neighbors of fertility
|
|
Neighbors of lymphocyte count
|
|
Neighbors of insulin level
|
|
Neighbors of fibroblast phenotype
|
|
Neighbors of cell development
|
|
Neighbors of immune response
|
|
Neighbors of cell population
|
|
Neighbors of T-cell development
|
|
Neighbors of inflammatory response
|
|
Neighbors of wound healing
|
|
Neighbors of angiogenesis
|
|
Neighbors of innate immune response
|
|
Neighbors of cell function
|
|
Neighbors of macrophage activation
|
|
Neighbors of cell formation
|
|
Neighbors of epithelial to mesenchymal transition
|
|
Neighbors of immunity
|
|
Neighbors of cell proliferative response
|
|
Neighbors of chemotaxis
|
|
Neighbors of cell survival
|
|
Neighbors of osteoclast differentiation
|
|
Neighbors of cell phenotype
|
|
Neighbors of T-cell proliferation
|
|
Neighbors of tissue remodeling
|
|
Neighbors of cell adhesion
|
|
Neighbors of T-cell activation
|
|
Neighbors of endothelial cell proliferation
|
|
Neighbors of fibrogenesis
|
|
Neighbors of tumor growth
|
|
Neighbors of tissue repair
|
|
Neighbors of cell count
|
|
Neighbors of cell infiltration
|
|
Neighbors of SMC proliferation
|
|
Neighbors of lumen formation
|
|
Neighbors of endothelial cell migration
|
|
Neighbors of adipogenesis
|
|
Neighbors of lipid storage
|
|
Neighbors of cell damage
|
|
Neighbors of aging
|
|
Neighbors of cell motility
|
|
Neighbors of monocyte migration
|
|
Neighbors of fibroblast proliferation
|
|
Neighbors of adipocyte differentiation
|
|
Neighbors of microglial activation
|
|
Neighbors of regeneration
|
|
Neighbors of cell migration
|
|
Neighbors of cancer growth
|
|
Neighbors of smooth muscle cell migration
|
|
Neighbors of transendothelial migration
|
|
Neighbors of phagocytosis
|
|
Neighbors of leukocyte migration
|
|
Neighbors of osteoclast formation
|
|
Neighbors of cell invasion
|
|
Neighbors of heart function
|
|
Neighbors of hemopoiesis
|
|
Neighbors of ossification
|
|
Neighbors of T-cell function
|
|
Neighbors of immune system function
|
|
Neighbors of lung development
|
|
Neighbors of autophagy
|
|
Neighbors of transcription activation
|
|
Neighbors of senescence
|
|
Neighbors of tumor immunity
|
|
Neighbors of hepatocyte proliferation
|
|
Neighbors of cell transdifferentiation
|
|
Neighbors of neuroprotection
|
|
Neighbors of stem cell differentiation
|
|
Neighbors of neuronal death
|
|
Neighbors of cell growth
|
|
Neighbors of ROS generation
|
|
Neighbors of epithelial cell proliferation
|
|
Neighbors of cancer cell growth
|
|
Neighbors of hemato-encephalic barrier
|
|
Neighbors of cellular senescence
|
|
Neighbors of colony formation
|
|
Neighbors of cell differentiation
|
|
Neighbors of keratinocyte proliferation
|
|
Neighbors of cell homeostasis
|
|
Neighbors of psoriasis
|
|
Neighbors of inflammatory disease
|
|
Neighbors of atherosclerosis
|
|
Neighbors of fibrosis
|
|
Neighbors of colitis
|
|
Neighbors of injury
|
|
Neighbors of vascular remodeling
|
|
Neighbors of metastasis
|
|
Neighbors of carcinogenesis
|
|
Neighbors of chronic inflammation
|
|
Neighbors of inflammation
|
|
Neighbors of tumor microenvironment
|
|
Neighbors of pathological angiogenesis
|
|
Neighbors of obesity
|
|
Neighbors of vascular disease
|
|
Neighbors of diabetes mellitus
|
|
Neighbors of pneumonia
|
|
Neighbors of osteoarthritis
|
|
Neighbors of liver fibrosis
|
|
Neighbors of myocardial infarction
|
|
Neighbors of reperfusion injury
|
|
Neighbors of airway inflammation
|
|
Neighbors of insulin resistance
|
|
Neighbors of infection
|
|
Neighbors of vascular injury
|
|
Neighbors of renal injury
|
|
Neighbors of macrophage infiltration
|
|
Neighbors of liver injury
|
|
Neighbors of sepsis
|
|
Neighbors of death
|
|
Neighbors of autoimmune disease
|
|
Neighbors of ischemic stroke
|
|
Neighbors of dermatitis
|
|
Neighbors of neutrophil infiltration
|
|
Neighbors of heart disease
|
|
Neighbors of diabetic nephropathy
|
|
Neighbors of lung injury
|
|
Neighbors of systemic sclerosis
|
|
Neighbors of hepatocellular carcinoma
|
|
Neighbors of autoimmunity
|
|
Neighbors of gastric cancer
|
|
Neighbors of colorectal cancer
|
|
Neighbors of cardiac remodeling
|
|
Neighbors of breast cancer
|
|
Neighbors of systemic lupus erythematosus
|
|
Neighbors of melanoma
|
|
Neighbors of collagen-induced arthritis
|
|
Neighbors of cartilage degeneration
|
|
Neighbors of interstitial fibrosis
|
|
Neighbors of neoplasm invasion
|
|
Neighbors of kidney disease
|
|
Neighbors of heart failure
|
|
Neighbors of lung disease
|
|
Neighbors of pulmonary fibrosis
|
|
Neighbors of cardiovascular disease
|
|
Neighbors of cancer
|
|
Neighbors of type 2 diabetes
|
|
Neighbors of neoplasm
|
|
Neighbors of neointima
|
|
Neighbors of vasculitis
|
|
Neighbors of atrophy
|
|
Neighbors of diet-induced obesity
|
|
Neighbors of myocardial fibrosis
|
|
Neighbors of coronary artery disease
|
|
Neighbors of rupture
|
|
Neighbors of prostate cancer
|
|
Neighbors of hypertrophy
|
|
Neighbors of osteolysis
|
|
Neighbors of ovarian cancer
|
|
Neighbors of hypertension
|
|
Neighbors of intimal hyperplasia
|
|
Neighbors of proteinuria
|
|
Neighbors of hepatic stellate cell
|
|
Neighbors of lung
|
|
Neighbors of liver
|
|
Neighbors of airway
|
|
Neighbors of aorta
|
|
Neighbors of esophagus
|
|
Neighbors of ovary
|
|
Neighbors of immune system
|
|
Neighbors of glands
|
|
Neighbors of ankle joint
|
|
Neighbors of knee joint
|
|
Neighbors of hip region
|
|
Neighbors of NF-kB family
|
|
Neighbors of oxidized LDL
|
|
Neighbors of PPAR
|
|
Neighbors of Jun/Fos
|
|
Neighbors of PKC
|
|
Neighbors of mitogen-activated protein kinase
|
|
Neighbors of transforming growth factor
|
|
Neighbors of Ras GTPase
|
|
Neighbors of PKA
|
|
Neighbors of ovalbumin
|
|
Neighbors of LDL
|
|
Neighbors of NF-AT family
|
|
Neighbors of NAD(P)H oxidase
|
|
Neighbors of SMAD subfamily
|
|
Neighbors of LXR
|
|
Neighbors of estrogen receptor
|
|
Neighbors of PDGF-BB
|
|
Neighbors of Notch
|
|
Neighbors of heat shock protein 90
|
|
Neighbors of Ang II receptor
|
|
Neighbors of proteasome endopeptidase complex
|
|
Neighbors of class nuclear receptor with C4 zinc fingers
|
|
Neighbors of non-coding RNA
|
|
Neighbors of histone H3
|
|
Neighbors of retinoid-X receptor subfamily
|
|
Neighbors of RA receptor
|
|
comon ps_pos, pprarg_neg targets
|
|
Model of PPARG signaling in psoriasis
|
|
PPARG negative regulators and targets
|
|
Model of PPARG related pathways in psoriasis (short version)
|
|
sars-cov binding
|
|
sars-cov no binding
|
|
New Pathway
|
|
1_Differentiation of psoriatic T cells
|
|
3_TGFB signaling provokes endochondral ossification with osteophyte formation
|
|
3_The role of interstitial fibroblasts in pyelonephritis
|
|
3_Mesangial cell dysfunction in glomerulonephritis
|
|
2_Podocyte dysfunction in glomerulonephritis
|
|
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
|
|
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
|
|
2_Cardiomyocyte hypertrophy
|
|
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
|
|
2_Defective tolerance of autoreactive T-cell in T1D
|
|
DIPG non histone mutations
|
|
DIPG overview_2
|
|
Differentiation of psoriatic T cells
|