Protein FLT1

URN urn:agi-llid:2321
Total Entities 0
Connectivity 4262
Name FLT1
Description fms related tyrosine kinase 1
Notes This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway VEGFA/NOTCH1/WNT Cross-talk in Blood Vessel Sprouting and Branching in Cancer
Proteins Involved in Arterial Hypertension
Proteins with Altered Expression in Melanoma
Melanoma
Proteins Involved in Melanoma
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Proliferative Diabetic Retinopathy
Cetuximab Resistance in Colorectal Cancer
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Proteins Involved in Astrocytoma
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins with Altered Expression in Breast Cancer
Breast Cancer
Endometrial Cancer
Proteins Involved in Endometrial Cancer
Proteins with Altered Expression in Endometrial Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in High-Grade Serous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins with Altered Expression in Ovarian Cancer
Netrin-1 Signaling in Age-Related Macular Degeneration
Proteins Involved in Age-Related Macular Degeneration
HIF1A in Pathologic Ocular Neovascularization
VEGFA in Neovascular Glaucoma
VEGFA Low Expression Level in Chronic Bronchitis
CSF2 -> NF-kB Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
VIP Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HIF1A in Vasculogenic Mimicry of Cancer
HIF1A as Master Regulator of Angiogenesis in Cancer
INHBA/ACVR2/BMPR Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
AGT -> TP53 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
Elevated Receptors -> Expression Targets in Placenta
VEGF Signaling
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
IL1B Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFC -> CTNNB Expression Target
VEGFC -> ATF Expression Target
VEGFA -> FOXO3A Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> CTNNB Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> FOXO3A Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of renal hypertrophy
Neighbors of vascular tone
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of fertility
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of renal hypertrophy
Neighbors of vascular tone
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of fertility
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of monocyte migration
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of senescence
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of macrophage function
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of airway inflammation
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of ischemic stroke
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of diet-induced obesity
Neighbors of myocardial fibrosis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of fibroblast
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of trophoblast
Neighbors of mononuclear cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of activated T-cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of cardiac myocyte
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of insulin-secreting cell
Neighbors of hematopoietic cell
Neighbors of podocyte
Neighbors of pericyte
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of retina cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of lymph node
Neighbors of blood vessel
Neighbors of heart
Neighbors of microvessel
Neighbors of placenta
Neighbors of carotid artery
Neighbors of uterus
Neighbors of retina
Neighbors of omentum
Neighbors of arteriole
Neighbors of villus
Neighbors of eye
Neighbors of hippocampus
Neighbors of cerebral cortex
Neighbors of bladder
Neighbors of Fallopian tube
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of PKC
Neighbors of PI3K
Neighbors of mitogen-activated protein kinase
Neighbors of TLR
Neighbors of cytokine
Neighbors of JAK
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of adipokine
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of inflammatory cytokine
Neighbors of estrogen receptor
Neighbors of PDGF-BB
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of fibrinogen
Neighbors of interleukin-35
Neighbors of Ang II receptor
Neighbors of proteasome endopeptidase complex
Neighbors of alpha2 adrenoceptor
Neighbors of vitronectin receptor (integrin)
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of PP2B
Neighbors of AHR subfamily
Neighbors of endostatins
Neighbors of relaxin
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
3_Enhanced angiogenesis in endometriosis

Group Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 2321

LocusLink ID 2321
14254
54251

Alias FMS-like tyrosine kinase I
Vascular endothelial growth factor receptor I
embryonic receptor kinase 2
sFlt I
VEGF receptor 1
Vascular endothelial growth factor receptor 1
Flt I
OTTMUSP00000023727
VEGFR I
VEGFA receptor 1
Tyrosine- protein kinase FRT
Fms like tyrosine kinase receptor
Vascular permeability factor receptor
vascular endothelial growth factor/vascular permeability factor receptor
VEGF-R1
Vascular permeability factor receptors
VEGF-A receptor 1
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase I
soluble VEGFR1 variant 2
VEGFR1
Flt 1 receptor
VEGF receptor I
Tyrosine-protein kinase receptor FLT
VEGF receptor FLT1
AI323757
soluble VEGF receptor 1-14
soluble VEGFR1 variant 21
receptor Flt1
FMS-like tyrosine kinase 1
vasculotropin receptor 1
VGR1_HUMAN
FRT
VEGF-A receptor FLT1
sFlt1
Flt1
VEGFA receptor FLT1
FLT
FLT-1
VEGFR-1
tyrosine-protein kinase FRT
vascular endothelial growth factor receptor-1
fms-related tyrosine kinase 1

EC Number 2.7.10.1

GO ID 0005524
0036326
0036327
0019838
0036332
0004714
0038085
0005021
0048514
0030154
0016477
0035924
0048598
0002548
1905563
0018108
0070374
0043406
0043410
0045766
0030335
0008284
0043552
0014068
0010863
0030949
0046777
0002040
0007169
0048010
0036323
0038084
0015629
0005768
0005615
0005925
0005887
0005886
0043235
0016301
0000166
0004672
0004713
0016740
0001525
0001569
0006935
0007275
0016310
1901534
0048597
0006468
0001666
0016021
0016020
0005634
0000186
0030522
0048661
0006940
0016772
0005794
0005737
0005730
0004716
0048146
0023014

KEGG ID hsa:2321
mmu:14254
rno:54251

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 5 87.01 cM

OMIM ID 165070

Rat chromosome position 12p11

Hugo ID 3763
HGNC:3763

Human chromosome position 13q12.3
13q12

Swiss-Prot Accession P17948
L7RSL3
P17948.2
A0A0R4J0A4
P35969
P35969.1
A3E342
A3E344
A8KA71
B0LPF1
B2BF46
B2BF47
B2BF48
B3FR89
B5A923
F5H5L6
O60722
P16057
Q12954
O55094
Q61517
P53767

PIR ID A49636
S09982
I78875
S49010
I60598

GenBank ID NC_000013
XM_017020485
XP_016875974
NM_002019
NP_002010
NM_001160030
NP_001153502
XM_011535014
XP_011533316
NM_001159920
NP_001153392
NM_001160031
NP_001153503
NG_012003
AL138712
AL139005
CH471075
EAX08431
EAX08432
CQ871317
CAH56859
CS172284
CAJ33638
D00133
BAA00080
EU332841
ABY87530
HD077716
CBW44131
JX512442
AGC09589
KF002712
AGL73885
KF002713
AGL73886
KF206396
AGS56393
KF206397
KF206398
AGS56394
KF206399
KF680656
AHC08482
KF680657
AHC08483
KF680658
AHC08484
KF680659
AHC08485
KF680660
AHC08486
KF680661
AHC08487
KF680662
AHC08488
KF680663
AHC08489
KF854284
AHO49116
KF854285
AHO49117
KF897924
AHO49114
KF897925
AHO49115
AB209050
BAD92287
AF063657
AAC16449
AK092472
AK292936
BAF85625
AK300392
BAG62125
AK309901
BC029849
BC039007
AAH39007
BE180461
BU151621
BX504049
CA396081
DA844548
DA851664
DQ836394
ABI53803
DQ836395
ABI53804
DQ836396
ABI53805
EF484674
EF491868
ABS32268
EF491869
ABS32269
EF491870
ABS32270
EU360600
ACB05747
EU368830
ACA62948
EU443152
ACA21474
EU826561
ACF47597
EU826562
ACF47598
JF509744
AFC77954
JF509745
AFC77955
S77812
AAB34001
S77814
AAB34002
U01134
AAC50060
P17948
NC_000071
NM_010228
NP_034358
XM_011241000
XP_011239302
XM_006504801
XP_006504864
XM_006504802
XP_006504865
XM_006504803
XP_006504866
NM_001363135
AC122299
AC131730
AF473823
AAQ05293
AJ224863
CH466614
EDL05837
EDL05838
EDL05839
AJ001177
CAA04571
AK004721
BAB23504
AK005502
BAB24084
AK013236
BAB28733
AK035771
AK084177
AK146906
BAE27519
AK167497
BAE39574
AK167596
BC029674
AAH29674
BP763953
D88689
BAA24498
D88690
BAA24499
L07297
AAA40078
X78568
CAA55311
P35969
NC_018924
AMYH02027768
AMYH02027769
AC_000027
AAHY01050787
AAHY01050788
AAHY01050789
AAHY01050790
AAHY01050791
AAHY01050792
AAHY01050793
AAHY01050794
AAHY01050795
AAHY01050796
AAHY01050797
AAHY01050798
AC_000145
ABBA01035724
ABBA01035725
ABBA01035726
NC_005111
NM_019306
NP_062179
AC_000080
AABR06070259
AABR06070260
AAHX01071023
AAHX01071024
AAHX01071025
AAHX01071026
AAHX01071027
CH474012
EDL89555
EDL89556
AF157595
AAF80356
D28498
BAA05857
P53767

Swiss-Prot ID VGFR1_HUMAN
VGFR1_MOUSE
VGFR1_RAT

Cell Localization Cell membrane
Endosome
Secreted
Cytoplasm
Plasma membrane

Ensembl ID ENSG00000102755
ENSP00000484039.1
ENST00000615840.4
ENSP00000437631.1
ENST00000541932.5
ENSP00000442630.1
ENST00000539099.1
ENSP00000282397.4
ENST00000282397.9
ENSMUSG00000029648
ENSMUSP00000031653.5
ENSMUST00000031653.11
ENSMUSP00000106158.1
ENSMUST00000110529.5
ENSP00000484039
ENST00000615840
ENSP00000437631
ENST00000541932
ENSP00000442630
ENST00000539099
ENSP00000282397
ENST00000282397
ENSMUSP00000031653
ENSMUST00000031653
ENSMUSP00000106158
ENSMUST00000110529

MGI ID MGI:95558
95558

RGD ID 2621

Unigene ID Hs.594454
Mm.389712
Rn.10239

Homologene ID 134179
20463

Shape Stick-vertex