Protein SPI1

URN urn:agi-llid:6688
Total Entities 0
Connectivity 2117
Name SPI1
Description Spi-1 proto-oncogene
Notes This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Thrombopoietin Receptors Signaling in Platelet Maturation
Immunoglobulin Genes Transcriptional Activation
Proplatelet Maturation
Hematopoietic Cell Lineage: B-cell (mouse)
Hematopoietic Cell Lineage: B-cell
IL17 Signaling in Psoriasis
Proteins Involved in Acute Myeloid Leukemia
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
Hodgkin Lymphoma
Hodgkin and Reed-Sternberg Cells Reprogramming
Proteins Involved in Osteopetrosis
Thrombopoietin -> SPI1 Expression Targets
Possible Interplay between SOX11, CCND1 and EZH2 in Mantle Cell Lymphoma
2_Interleukin-17 and interleukin-22 signaling in psoriasis
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Acute Myeloid Leukemia

MedScan ID 6688
634396

LocusLink ID 6688
20375
366126

Alias Oncogene SPI I
Dis I
LOC100503306
Tfpu.1
SPI1
spleen focus forming virus (SFFV) proviral integrating oncogene spi I
Tcfpu1
hCG_25181
Oncogene SPI1
RP23-20F9.1
spleen focus forming virus (SFFV) proviral integration oncogene
Sfpi1
31 kDa transforming protein
Sfpi I
SFFV proviral integration 1
SFFV proviral integration I
spi-a
OTTMUSP00000015228
Tcfpu I
PU.1
SPI-1 proto-oncogene
SPI I
Dis1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
spleen focus forming virus proviral integration oncogene spi1
SFFV proviral integrating 1
PU.1 transcription factor
spleen focus forming virus (SFFV) proviral integrating oncogene spi1
hematopoietic transcription factor PU.1
spleen focus forming virus (SFFV) proviral integration oncogene spi I
PU1_HUMAN
SFFV proviral integrating I
Transcription factor PU.1
OF
SPI-1
Dis-1
Sfpi-1
31 kDa-transforming protein
SFFV proviral integration 1 protein

GO ID 0001228
0003700
0000981
0001227
0051525
0003723
0000980
0000978
0001085
0008134
0060033
1902262
0030154
0071361
0030218
0030851
0043966
0044027
0070102
0030098
0002320
0030225
0043011
0045347
0045814
0090241
0000122
0045892
1902895
0045944
0045893
0061614
0045646
0006357
0035019
0000790
0005654
0005634
0005667
0003677
0043565
0002573
0006355
0001944
0006917
0000979
0006351
0001077
0005515
0006366
0000982
0001078
0003705
0001205
0001047

KEGG ID hsa:6688
mmu:20375
rno:366126

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 2 50.44 cM
2 47.5 cM

OMIM ID 165170

Rat chromosome position 3q24

Hugo ID 11241
HGNC:11241

Human chromosome position 11p11.2

Swiss-Prot Accession P17947
P17947.2
P17433
Q3U5L4
P17433.2
Q6BDS1
Q6BDS1.1
Q99L57
Q5BK69

PIR ID S60367
A34693

GenBank ID NC_000011
XM_011520307
XP_011518609
XM_017018173
XP_016873662
NM_003120
NP_003111
NM_001080547
NP_001074016
AC090559
AC090582
CH471064
EAW67924
EAW67925
EAW67926
JC009148
CDL93508
KT583843
U34046
AAC50247
AK310065
BI519776
BI909430
BM561863
BP271276
CD368431
X52056
CAA36281
P17947
NC_000068
XM_011239397
XP_011237699
XM_017316733
XP_017172222
NM_011355
NP_035485
XM_006499038
XP_006499101
AL691450
CH466519
EDL27526
AA239990
AA789819
AK142246
BAE24993
AK153524
BAE32064
AK154945
BAE32942
AK155085
BAE33036
BC003815
AAH03815
CJ187167
L03215
AAB59699
M32370
AAA40024
M38252
AAA40110
X17463
CAA35502
P17433
NC_005102
XM_006234532
XP_006234594
NM_001005892
NP_001005892
AC_000071
AABR07052865
AAHX01023465
AAHX01023466
AAHX01023467
CH473949
EDL79507
AB154364
BAD35169
BC091185
AAH91185
Q6BDS1
XP_011518610
CAM17566
AAI11380
HG503770
AABR06024710
ABBA01060720
AMYH02024729
AMYH02024728
HG503768
HG503769
AAHY01018365
ABBA01060716
AAHY01018367
AAHY01018366
ABBA01060719
ABBA01060717
ABBA01060718
XM_011520305
XM_011520308
XM_011520306
BC111379
AC_000024
AC_000143
NC_018922
XP_011518608
XP_011518607

Swiss-Prot ID SPI1_HUMAN
SPI1_MOUSE
SPI1_RAT

Cell Localization Nucleus

Ensembl ID ENSG00000066336
ENSP00000227163.4
ENST00000227163.8
ENSP00000367799.3
ENST00000378538.7
ENSMUSG00000002111
ENSMUSP00000002180.7
ENSMUST00000002180.7
ENSRNOG00000012172
ENSRNOP00000016306.4
ENSRNOT00000016306.6
ENSP00000227163
ENSP00000367799
ENSRNOP00000016306
ENST00000378538
ENSRNOT00000016306
ENST00000227163
ENSMUSP00000002180
ENSMUST00000002180

MGI ID MGI:98282
98282

RGD ID 1359607

Unigene ID Hs.502511
Rn.230674
Mm.1302

Homologene ID 2346

IPI ID IPI00018333
IPI00827738
IPI00116335
IPI00464883