Protein CD14

URN urn:agi-llid:929
Total Entities 0
Connectivity 3076
Name CD14
Description CD14 molecule
Notes The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway TLR4 Signaling in Leukocytes
T-Cell Independent B-Cell Activation
Toll-like Receptors in Sterile Inflammation
MC1R in anti-Inflammatory Signaling
Eat me Signal: Apoptotic Cell Initiates Phagocytosis
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
AHR Signaling in M1 Macrophages Function
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
IL6 Expression Targets -> Nociception
Monoblast -> Promonocyte Surface Expression Markers
Myeloblast -> Neutrophil Surface Expression Markers
Myoblast -> Neutrophil Surface Expression Markers
Hemapoietic Stem Cell -> Lymphoid Multipotent Progenitor Surface Expression Markers
Proteins Involved in non-Alcoholic Fatty Liver Disease
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Proteins Involved in Helicobacter Infections
DupA Induced IL12 Production in Helicobacter Pylori Infection
Proteins Involved in Ulcerative Colitis
Antigen-Presenting Cell Role in Asthma
Monocytes Function in Gout
Dendritic Cell Dysfunction in Psoriatic Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in HIV Type 1 Infection
Toll-like Receptors (TLR) in Periodontitis
Cathepsins Role in Periodontitis
Proteins Involved in Periodontitis
Microglia Activation in Alzheimer's Disease
Microglia Activation in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Immune System Role in Otitis Media
Genes with Mutations Associated with Asthma
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
Toll-like Receptors in Pyelonephritis
HMGB1 Expression Targets
Epinephrine/Gs Expression Targets
Epinephrine/Gq Expression Targets
Elevated Receptors -> Expression Targets in Adipose Tissue
Elevated Receptors -> Expression Targets in Joint
Elevated Receptors -> Expression Targets in Mouth
Elevated Receptors -> Expression Targets in Colon
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> STAT Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IFNG/IFNR Expression Targets
IL3 Expression Targets
IL6 Expression Targets
PGE1 Expression Targets
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
NOTCH -> Expression Targets in Thymus
Elevated Receptors -> Expression Targets in Thymus
CSF1 -> STAT Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR4 -> IRF Signaling
TLR4/5/7/9 -> NF-kB Signaling
TLR -> AP-1 Signaling
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of lethality
Neighbors of tumor response
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight gain
Neighbors of tumor recurrence
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of viral load
Neighbors of leukocyte count
Neighbors of fasting plasma glucose
Neighbors of gastric cancer risk
Neighbors of comorbidity
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of lethality
Neighbors of tumor response
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight gain
Neighbors of tumor recurrence
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of viral load
Neighbors of leukocyte count
Neighbors of fasting plasma glucose
Neighbors of gastric cancer risk
Neighbors of comorbidity
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of inflammatory response
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of bone resorption
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of ossification
Neighbors of T-cell function
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of cell transdifferentiation
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of life span
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of carcinogenesis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of neoplasm
Neighbors of coronary artery disease
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of hypertension
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of microglia
Neighbors of intestine epithelium cell
Neighbors of hepatocyte
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of inflammatory cell
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of myeloid cell
Neighbors of stem cell
Neighbors of leukocyte
Neighbors of mammary epithelial cell
Neighbors of peripheral lymphocyte
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of airway
Neighbors of blood vessel
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of carotid artery
Neighbors of synovial membrane
Neighbors of retina
Neighbors of pancreas
Neighbors of lymphatic system
Neighbors of ankle joint
Neighbors of vitreous body
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of IFNAR ligand
Neighbors of cytokine
Neighbors of interferon
Neighbors of ERK1/2
Neighbors of PKA
Neighbors of IgG
Neighbors of HDL
Neighbors of histone deacetylase
Neighbors of GPCR
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of histone H3
Neighbors of retinoid-X receptor subfamily
Neighbors of TORC1
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of neuropeptides
Model of PPARG signaling in psoriasis
Overview. Diseases of the respiratory (chapter 9)
1_The role of Toll-like receptors in pyelonephritis
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
4_1_Polymorphisms associated with inflammatory bowel diseases

Group Genes Associated with Ulcerative Colitis
Genes with Mutations Associated with Asthma

MedScan ID 929

LocusLink ID 929
12475
60350

Alias Myeloid cell-specific leucine-rich glycoprotein
OTTHUMP00000223710
CD14
monocyte surface glycoprotein CD14
Monocyte differentiating antigen CD14
CD14 antigen
CD14_HUMAN
Monocyte differentiation antigen CD14
OTTHUMP00000223711
antigen cd14
CD14 molecule
Monocyte differentiation antigen CD14 precursor
Monocyte differentiating antigen CD14 precursor
LPS-R
monocyte surface glycoprotein CD14 precursor

GO ID 0071723
0001530
0070891
0001847
0016019
0007249
0002755
0002756
0035666
0006915
0097190
0007166
0071726
0071222
0071223
0071219
0071727
0006954
0045087
0031663
0070266
0034128
0043312
0006909
1901224
0050715
0045807
0032729
2000484
0032760
0032481
0006898
0051602
0045471
0009408
0032026
0034612
0034142
0038123
0038124
0002224
0005794
0031362
0009986
0010008
0009897
0070062
0005576
0005615
0046696
0045121
0005886
0030667
0002376
0009617
0002237
0031225
0016020
0032496
0034134
0034138
0008063
0006950
0005515
0006955
0070391
0019898
0048503

KEGG ID hsa:929
mmu:12475
rno:60350

MedLine Reference 10395652
10575214
11076863
11083760
11145656
11489942
11745332
11779220
11810121
11825494
11841490
11854210
11876746
11932927
11935032
12011764
12067299
12106839
12117913
12140663
12171914
12174084
12196527
12207338
12324469
12410798
12417309
12438323
12477932
12594207
12624278
12626456
12663765
12679473
12700637
12731067
12754215
12757265
12825176
12832426
12853157
12897754
12911501
12938192
12942028
12960274
14500479
14508193
14517492
14648231
14672339
14673018
14706103
15034063
15069085
15080833
15081257
15116260
15120158
15166925
15257175
15269840
15358661
15373760
15378299
15489334
15489336
15491315
15558232
15591473
15602630
15619435
15655821
15670766
15714129
15753758
15764151
15778383
15842262
15932345
15946916
15975149
16038043
16061600
16101942
16142747
16165702
16239565
16266379
16273620
16273622
16275943
16283111
16290232
16335952
16344560
16368002
16381901
16387800
16437636
16443672
16444757
16467036
16473828
16492974
16552356
16611358
16625214
16706818
16751411
16785528
16848791
16860318
16933467
16950521
17003960
17007028
17046070
17052752
17086894
17098305
17126402
17205552
17217435
17259806
17274987
17304102
17309585
17436151
17438094
17448042
17471431
17515856
17565650
17600225
17617027
2448876
2453848
2462937
2472171
2779588
3385210
7583357
8798531
9142045
9548256
9562334
9655682
10047547
10202023
10221645
10349636
10679400
11035061
11042159
11076861
11123339
11217851
11254735
11796577
11870620
12146799
12165539
12239221
12244136
12244198
12370383
12391013
12424240
12427659
12466851
12482856
12496149
12639839
12935356
12964032
14516777
14517279
14614560
14742577
14752288
15034566
15142274
15194867
15208271
15240706
15271679
15306695
15322035
15331624
15459483
15522312
15541715
15557205
15585870
15611337
15644310
15661914
15724245
15731076
15755524
15795240
15814723
15895089
15896296
15941778
16081822
16141072
16141073
16148141
16163057
16188968
16204620
16210672
16225933
16229899
16237099
16428731
16439470
16480837
16574244
16705022
1694207
16980981
16995947
17039565
17167049
17283106
17292937
17384086
17456769
17474083
2467257
7532683
8612135
8706013
8921956
9127007
9353071
9665271
10854787
12046090
12113681
12218159
12632533
14572767
14599981
15153652
15310678
16879219
8598386
9201265
9784508

CellType squamous epithelial cells
urothelial cells
smooth muscle cells
cells in endometrial stroma
cells in red pulp
glandular cells
cells in white pulp
decidual cells
Macrophages
trophoblastic cells
Pneumocytes
germinal center cells
myocytes
Purkinje Cells
cells in seminiferus ducts
non-germinal center cells
glial cells
epidermal cells
Leydig Cells
respiratory epithelial cells
neuronal cells
cells in glomeruli
follicle cells
cells in tubules
ovarian stroma cells
lymphoid tissue
exocrine glandular cells
hematopoietic cells
islets of Langerhans
bile duct cells
Hepatocytes
cells in granular layer
cells in molecular layer

Tissue tonsil
urinary bladder
smooth muscle
uterus, post-menopause
spleen
parathyroid gland
Placenta
Lung
uterus, pre-menopause
stomach, lower
gall bladder
stomach, upper
Prostate
lymph node
heart muscle
Cerebellum
vagina
testis
rectum
hippocampus
cerebral cortex
vulva/anal skin
Salivary gland
nasopharynx
thyroid gland
seminal vesicle
oral mucosa
Kidney
cervix, uterine
Adrenal gland
skeletal muscle
Ovary
Appendix
Skin
lateral ventricle
colon
small intestine
Pancreas
duodenum
bone marrow
Liver
epididymis
breast
esophagus
bronchus
fallopian tube

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 18 19.46 cM
18 31.0 cM

OMIM ID 158120

Rat chromosome position 18p11

Hugo ID 1628
HGNC:1628

Human chromosome position 5q31.3
5q31.1
5q22-q32

Swiss-Prot Accession P08571
P08571.2
P10810
Q3UB18
Q3UE54
Q4FJP7
P10810.1
Q63691
Q63691.2
Q53XT5
Q96FR6
Q96L99
Q9UNS3
Q6GT04
Q3TE16
Q3U6A3
Q91V69
Q91VC2
Q91VD3
Q920X7
Q920X8
Q920X9
O88955

PIR ID A27637
S03605

GenBank ID NC_000005
NM_001174104
NP_001167575
NM_001174105
NP_001167576
NM_001040021
NP_001035110
NM_000591
NP_000582
NG_023178
AC116353
CH471062
EAW62037
HQ199230
ADX31876
U00699
AAA20640
X06882
CAA29999
AB446505
BAG55282
AF097942
AAC83816
AK313277
BAG36085
AY044269
AAL02401
BC010507
AAH10507
BP300412
BT007331
AAP35995
CF593452
DA269805
DA426297
DA681405
M86511
AAA51930
W74441
X13334
CAA31711
P08571
NC_000084
NM_009841
NP_033971
AB039054
BAB68578
AB039056
BAB68580
AB039057
BAB68581
AB039058
BAB68582
AB039059
BAB68583
AB039060
BAB68584
AB039061
BAB68585
AB039062
BAB68586
AC027740
CH466557
EDK97172
D10912
M34510
AAA37387
X13987
CAA32166
AK149744
BAE29057
AK151139
BAE30146
AK152427
AK153229
BAE31822
AK156262
BAE33646
AK169880
BAE41432
BC057889
AAH57889
BY498446
CT010355
CAJ18563
EH108279
X13333
CAA31710
P10810
NC_005117
XM_006254603
XP_006254665
NM_021744
NP_068512
AC_000086
AAHX01094551
AC125248
AF087944
AAC35372
CH473974
EDL76309
AF087943
AAC35371
BC061733
AAH61733
FQ219480
U51804
AAB01154
Q63691
NC_018916
AMYH02012340
AM392692
CAL37570
AM392824
CAL37702
AM393386
CAL38264
AM393697
CAL38573
AC_000040
AAHY01137757
AC_000137
ABBA01026424
AB039055
BAB68579
NT_029289
NW_001838953
NW_922784
AC_000048
CR590334
CR590355
CR590525
CR591451
CR593752
CR594268
CR595571
CR598974
CR600557
CR600702
CR601474
CR602302
CR603280
CR603424
CR605705
CR609600
CR610580
CR610684
CR612020
CR613552
CR614015
CR614726
CR616071
CR616612
CR617446
CR620138
CR620234
CR620555
CR626311
CR626579
NT_039674
NW_001030631
Q3TE16
Q3U6A3
Q3UB18
Q3UE54
Q4FJP7
Q91V69
Q91VC2
Q91VD3
Q920X7
Q920X8
Q920X9
NW_001084735
NW_047511
O88955
Q53XT5
117644414
117645596
117646212
117646910
119582441
121946438
14714729
15667229
180021
20141203
29741
30583501
312399
3983127
74754961
Q0JSE1
115957
123783222
123784372
123790973
123794411
123797626
148664756
15822854
15822856
15822858
15822860
15822862
15822864
15822866
15822868
15822870
2342527
34784392
387121
50339
71060039
74139974
74185341
74199487
74207846
74220943
81867324
81867331
81867332
81867579
81867580
81867581
1262920
146345387
149017258
3599525
3599527
38197682
81861565

Swiss-Prot ID CD14_HUMAN
CD14_MOUSE
CD14_RAT
Q4FJP7_MOUSE

Cell Localization Cell membrane
Secreted
Membrane raft
Golgi apparatus
Plasma membrane

Ensembl ID ENSG00000170458
ENSP00000304236.6
ENST00000302014.11
ENSP00000385519.2
ENST00000401743.6
ENSMUSG00000051439
ENSMUSP00000056669.6
ENSMUST00000061829.7
ENSRNOG00000017819
ENSRNOP00000023977.3
ENSRNOT00000023977.6
ENSP00000304236
ENST00000302014
ENSP00000385519
ENST00000401743
ENSMUSP00000056669
ENSMUST00000061829
ENSRNOP00000023977
ENSRNOT00000023977

MGI ID MGI:88318
88318

RGD ID 620588

Unigene ID Hs.163867
Mm.3460
Rn.42942
Hs.638333

Homologene ID 493

Shape Stick-vertex

IPI ID IPI00029260
IPI00308990
IPI00231949

Homo sapiens Chromosome position 5q22-q32

Ensembl Transcript ID ENST00000302014
ENST00000401743

FunctionalClass GPI anchor binding
peptidoglycan receptor
protein binding

Mus musculus Chromosome position 18 31.0 cM

KEGG pathway Hematopoietic cell lineage
MAPK signaling pathway
Regulation of actin cytoskeleton
Toll-like receptor signaling pathway

Rattus norvegicus Chromosome position 18p11

Ensembl Gene ID ENSG00000170458