URN | urn:agi-llid:3556 |
---|---|
Total Entities | 0 |
Connectivity | 402 |
Name | IL1RAP |
Description | interleukin 1 receptor accessory protein |
Notes | This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
Pathway | Osteoarthritis |
---|---|
Th17-Cell Differentiation | |
Bradykinin Effects in Inflammation | |
Toll-like Receptor Independent Sterile Inflammation | |
Mast-Cell Activation without Degranulation | |
Negative Acute Phase Proteins Synthesis | |
Positive Acute Phase Proteins Synthesis | |
Vascular Endothelial Cell Activation by Cytokines | |
IL1B Expression Targets -> Nociception | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Inflammatory Reaction in Acne Vulgaris | |
Keratinocyte Proliferation in Acne Vulgaris | |
T-Cells Differentiation Block in Psoriasis | |
Th17-Cell Function in Systemic Lupus Erythematosus | |
Vitiligo | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
beta-Cell Destruction through Cytokines in Diabetes Mellitus | |
CD4+T-Cell Response in Celiac Disease | |
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis | |
TSLP Signaling in Bronchial Epithelial Cell in Asthma | |
Th17-Cell Differentiation in Asthma | |
CFTR Expression in Epithelial Cells (Class I Mutations) | |
Osteoclast Activation in Gout | |
Neutrophil Recruitment in Sinovium in Gout | |
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis | |
IL1B Induced Arthralgia | |
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis | |
Osteoclast Activation in Psoriatic Arthritis | |
Synovial Fibroblast Activation in Psoriatic Arthritis | |
Osteoclast Activation in Rheumatoid Arthritis | |
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis | |
Th17-Cell Numbers Reduction in HIV | |
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA) | |
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA) | |
HMGB1 and IL1B in Neuroinflammation | |
HMGB1 and IL1B in Neuronal Hyperexcitation | |
Subepithelial Fibroblasts in Middle Ear Cholesteatoma | |
Cytokines Trigger Otitis Media | |
Mucin Hyperproduction in Goblet and Mucous Cells | |
Endothelial Cell Dysfunction in Glomerulonephritis | |
Endothelial Cell Dysfunction in Pyelonephritis | |
NFKB Canonical Signaling Activation in Cancer | |
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis | |
NFKB Signaling Activation by Blocking of Tumor Suppressors | |
IL1R -> STAT3 Signaling | |
IL1R -> NF-kB Signaling | |
NF-kB Canonical Signaling | |
IL1B Expression Targets | |
IL1A Expression Targets | |
PPAR Psoriasis | |
Model of PPARG signaling in psoriasis | |
1_Inflammation in keratinocytes in the pathology of acne | |
1_Differentiation of psoriatic T cells | |
1_TNF and IL1B provoke ECM degradation in osteoarthritis | |
2_Chondrocyte death in osteoarthritis | |
2_The role of endothelial cells in pyelonephritis | |
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media | |
2_Pathogens stimulate mucins expression in the middle ear | |
3_1_Mucus accumulation in asthma | |
4_Mucin hyperproduction in goblet and mucous cells in COPD | |
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature | |
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations) | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
drug-target moltransport | |
Differentiation of psoriatic T cells |
MedScan ID | 3556 |
---|
LocusLink ID | 3556 |
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16180 | |
25466 |
Alias | interleukin IL1R3 |
---|---|
6430709H04Rik | |
IL-1RACP | |
OTTHUMP00000209490 | |
interleukin IL1 receptor accessory protein beta | |
interleukin IL-1RACP | |
OTTHUMP00000209488 | |
OTTHUMP00000209486 | |
interleukin IL1 receptor accessory protein | |
Il1racpb | |
interleukin-1 receptor 3 | |
FLJ37788 | |
MGC114349 | |
interleukin IL-1R AcP | |
AI255955 | |
AV239853 | |
interleukin IL1 RAP | |
OTTHUMP00000209492 | |
OTTHUMP00000209491 | |
IL-1R AcP | |
interleukin-1 receptor accessory protein beta | |
IL-1 receptor accessory protein | |
OTTHUMP00000209487 | |
C3orf13 | |
RIKEN cDNA 6430709H04 gene | |
interleukin 1 receptor accessory protein | |
IL1 RAP | |
IL1R3 | |
OTTHUMP00000209489 | |
interleukin-33 receptot beta chain | |
interleukin-1 receptor accessory protein | |
IL-1R3 | |
IL-1R-3 |
GO ID | 0004908 |
---|---|
0005149 | |
0002114 | |
0019221 | |
0006955 | |
0006954 | |
0045087 | |
0070498 | |
0042094 | |
0038172 | |
0072602 | |
0051092 | |
0032736 | |
0032754 | |
2000778 | |
0051965 | |
0065003 | |
0099151 | |
1905606 | |
0099560 | |
0099545 | |
0005576 | |
0098978 | |
0005887 | |
0016020 | |
0005886 | |
1990782 | |
0002376 | |
1900006 | |
0007165 | |
0005737 | |
0005615 | |
0016021 | |
0032991 | |
0019966 | |
0030674 | |
0004871 | |
0006461 | |
0043234 | |
0005622 | |
0004888 | |
0031224 | |
0004872 |
KEGG ID | rno:25466 |
---|---|
hsa:3556 | |
mmu:16180 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 16 |
---|
OMIM ID | 602626 |
---|
Rat chromosome position | 11q22 |
---|
Hugo ID | 5995 |
---|---|
HGNC:5995 |
Human chromosome position | 3q28 |
---|
Swiss-Prot Accession | A8K6K4 |
---|---|
Q9NPH3 | |
Q9NPH3.2 | |
E9Q6I2 | |
Q3V2X3 | |
Q61730 | |
Q3UEL3 | |
Q61730.1 | |
D1M8S3 | |
Q63621 | |
Q63621.1 | |
B1NLD0 | |
D3DNW0 | |
O14915 | |
Q86WJ7 | |
Q3UVZ1 | |
Q8VCB9 | |
Q8N9C1 | |
Q4V8K9 | |
Q76LI3 |
PIR ID | A57535 |
---|
Swiss-Prot ID | IL1AP_RAT |
---|---|
IL1AP_HUMAN | |
IL1AP_MOUSE | |
D1M8S3_RAT | |
A8K6K4_HUMAN | |
Q3UEL3_MOUSE | |
E9Q6I2_MOUSE | |
Q3V2X3_MOUSE | |
Q3UVZ1_MOUSE |
Cell Localization | Membrane |
---|---|
Cell membrane | |
Secreted | |
Plasma membrane |
Ensembl ID | ENSG00000196083 |
---|---|
ENSP00000401132.1 | |
ENST00000439062.6 | |
ENSP00000072516.3 | |
ENST00000072516.7 | |
ENSP00000387371.1 | |
ENST00000422940.5 | |
ENSP00000314807.3 | |
ENST00000317757.7 | |
ENSP00000390541.1 | |
ENST00000447382.6 | |
ENSP00000409352.1 | |
ENST00000422485.5 | |
ENSMUSG00000022514 | |
ENSMUSP00000128100.2 | |
ENSMUST00000166294.8 | |
ENSMUSP00000093843.2 | |
ENSMUST00000096129.8 | |
ENSMUSP00000023156.6 | |
ENSMUST00000023156.12 | |
ENSMUSP00000134202.1 | |
ENSMUST00000174202.7 | |
ENSRNOG00000001928 | |
ENSRNOP00000051260.4 | |
ENSRNOT00000043498.6 | |
ENSRNOP00000002645.3 | |
ENSRNOT00000002645.4 | |
ENST00000447382.5 | |
ENST00000439062.5 | |
ENSP00000401132 | |
ENST00000439062 | |
ENSP00000072516 | |
ENST00000072516 | |
ENSP00000387371 | |
ENST00000422940 | |
ENSP00000314807 | |
ENST00000317757 | |
ENSP00000390541 | |
ENST00000447382 | |
ENSP00000409352 | |
ENST00000422485 | |
ENSP00000408893 | |
ENST00000443369 | |
ENSMUSP00000128100 | |
ENSMUST00000166294 | |
ENSMUSP00000093843 | |
ENSMUST00000096129 | |
ENSMUSP00000023156 | |
ENSMUST00000023156 | |
ENSMUSP00000134202 | |
ENSMUST00000174202 | |
ENSRNOP00000051260 | |
ENSRNOT00000043498 | |
ENSRNOP00000002645 | |
ENSRNOT00000002645 |
MGI ID | MGI:104975 |
---|---|
104975 |
RGD ID | 2893 |
---|
Unigene ID | Rn.10511 |
---|---|
Hs.478673 | |
Mm.253424 |
Homologene ID | 1643 |
---|
Shape | Stick-vertex |
---|
IPI ID | IPI00031789 |
---|---|
IPI00107619 | |
IPI00337687 | |
IPI00925621 | |
IPI00211004 | |
IPI00113879 | |
IPI00124823 | |
IPI00563608 | |
IPI00653610 | |
IPI00929886 | |
IPI00337688 | |
IPI00167680 |