Protein STK11

URN urn:agi-llid:6794
Total Entities 0
Connectivity 2748
Name STK11
Description serine/threonine kinase 11
Notes This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling
Hypoxia Inhibits mTOR Signaling
SIRT3 Signaling in Aging
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Adiponectin in Insulin Resistance Prevention
Insulin Resistance in Myocytes Induced by Obesity
Insulin Resistance in Hepatocytes
Peutz-Jeghers Syndrome
Proteins Involved in Peutz-Jeghers Syndrome
Proteins Involved in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
STK11 Signaling in Pancreatic Neoplasms
Proteins Involved in Polycystic Ovary Syndrome
Ketogenic Diet Mechanism (Hypothesis)
Proteins Involved in Polycystic Kidney Disease
Podocyte Dysfunction in Glomerulonephritis
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
Genes with Mutations in Cancer Metabolic Reprogramming
Proteins with Altered Expression in Cancer Metabolic Reprogramming
Lysophosphatidic Acid/LPARs Signaling
AMPK Signaling
mTOR Signaling
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
4_3_Insulin resistance: FFA-related insulin resistance
Model of PPARG signaling in psoriais (tested)

Group Genes with Mutations Associated with Peutz-Jeghers Syndrome
Genes with Mutations Associated with Pancreatic Cancer
Proteins Involved in Cowden Syndrome
Genes with Mutations Associated with Endometrial Cancer
Genes with Mutations Associated with Ovarian Cancer

MedScan ID 6794

LocusLink ID 6794
20869
314621

Alias LKB1
OTTMUSP00000043767
R75140
serine/threonine kinase 11 (Peutz-Jeghers syndrome)
AA408040
OTTMUSP00000020599
polarization-related protein LKB1
renal carcinoma antigen NY-REN-19
LKB1 kinase
protein kinase LKB1
serine/threonine-protein kinase STK11
LKB1 short isoform
Serine/threonine- protein kinase LKB1
liver kinase B1 homolog
serine/threonine kinase 11
LKB I
hLKB1
liver kinase B1
mLKB1
Serine/threonine- protein kinase LKB I
OTTMUSP00000020600
STK11
PJS
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
Par-4

EC Number 2.7.11.1

GO ID 0005524
0030275
0000287
0002039
0030295
0004674
0051645
0050852
0032147
0043276
0006914
0007409
0060070
0007050
0006974
0071493
0097484
0030010
0042593
0072332
1904262
0090090
0030308
0008285
0120163
0060770
0010508
0050772
1900182
0030511
0045059
0046777
0006470
0006468
0001558
0048814
0051896
1901796
0010212
0007283
0001894
0001944
0005737
0005829
0070062
0016020
0005739
0005654
0005634
0016301
0046872
0000166
0004672
0044877
0016740
0036399
0006915
0007049
0030154
0051055
0016310
0045722
0050731
0071902
0051291
0030111
0033993
0007286
0036398
0032991
0033762
0043434
0032403
0043234
0006112
0008286
0042304
0044281
0016772
0045860

KEGG ID hsa:6794
mmu:20869

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 10

OMIM ID 602216
260350
273300
175200

Rat chromosome position 7q11

Hugo ID 11389
HGNC:11389

Human chromosome position 19p13.3

Swiss-Prot Accession A0A0S2Z4D1
Q15831
Q15831.1
Q9WTK7
Q3V4A1
Q9WTK7.1
A0A0H2UI02
D4AE59.1
B2RBX7
E7EW76
B3VBP0
Q3TAE0
D4AE59

GenBank ID NC_000019
NM_000455
NP_000446
NG_007460
AC004221
AAF97257
AC011544
AH005839
AAB97833
AH006100
AAC15742
CH471139
EAW69538
EAW69539
EAW69540
AB209553
BAD92790
AF035625
AAC39527
AF217978
AAG17221
AJ844634
CAH59749
AK128518
AK314858
BAG37374
BC007981
AAH07981
BC019334
AAH19334
BM993274
BQ222023
BU174122
BU739451
EF644172
ABR45718
GU573916
ADD71158
KU178339
ALQ33797
KU178340
ALQ33798
U63333
AAB05809
Q15831
NC_000076
XM_006513443
XP_006513506
XM_006513441
XP_006513504
XM_006513442
XP_006513505
NR_126043
NM_011492
NP_035622
NM_001301854
NP_001288783
NM_001301853
NP_001288782
XM_006513439
XP_006513502
AB026255
BAA86229
AC159999
AF145697
AAD55369
AH008186
AAD55368
CH466553
EDL31600
EDL31601
AB015801
BAA76749
AF129870
AAD22100
AF145287
AAD31044
AF151711
AAF21370
AK004499
BAE43183
AK147802
AK171909
BAE42728
AK172385
BAE42977
AK172528
BAE43050
BC052379
AAH52379
BE951985
BF468348
CD565465
CJ229363
CO424479
EU730638
ACE73833
KY779728
AVC68843
Q9WTK7
NC_005106
NM_001108069
NP_001101539
XM_008765096
XP_008763318
XM_006240910
XP_006240972
AC_000075
AAHX01047516
AC141331
CH474029
EDL89333
EDL89334
D4AE59
XM_011528209
XP_011526511
XM_005259617
XP_005259674
XR_936204
XM_005259618
XP_005259675
NC_018930
AF032984
AF032985
AF032986
AF055320
AF055321
AF055322
AF055323
AF055324
AF055325
AF055326
AF055327
AMYH02035142
DQ893232
ABM84158
DQ896561
ABM87560
AC_000032
AAHY01086929
AF145288
AF145289
AF145290
AF145291
AF145292
AF145293
AF145294
AF145295
AF145296
AF145297
AC_000151
ABBA01002630
ABBA01002631
XR_380381
XM_006513440
XP_006513503

Swiss-Prot ID STK11_HUMAN
STK11_MOUSE

Cell Localization Nucleus
Cytoplasm
Membrane
Mitochondrion

Ensembl ID ENSG00000118046
ENSP00000324856.6
ENST00000326873.11
ENSMUSG00000003068
ENSMUSP00000150488.1
ENSMUST00000213772.1
ENSMUSP00000101009.1
ENSMUST00000105370.7
ENSMUSP00000003152.7
ENSMUST00000003152.13
ENSRNOG00000014287
ENSRNOP00000057414.3
ENSRNOT00000060683.3
ENSP00000324856
ENST00000326873
ENSMUSP00000114195
ENSMUST00000144883
ENSMUSP00000101009
ENSMUST00000105370
ENSMUSP00000003152
ENSMUST00000003152
ENSRNOP00000057414
ENSRNOT00000060683
ENSP00000467240
ENST00000586243

MGI ID MGI:1341870

RGD ID 1308653

Unigene ID Hs.515005
Mm.44231
Rn.12052

Homologene ID 393

Shape Sickle-vertex