URN | urn:agi-llid:3459 |
---|---|
Total Entities | 0 |
Connectivity | 593 |
Name | IFNGR1 |
Description | interferon gamma receptor 1 |
Notes | This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
ObjectType | Protein |
Pathway | Natural Killer Cell Activation |
---|---|
T-Cell Cytotoxic Mediated Cell Death | |
Th1-Cell Differentiation | |
Proplatelet Maturation | |
Macrophage M1 Lineage | |
AHR Signaling in M1 Macrophages Function | |
Proteins Involved in Atherosclerosis | |
Th1-Cells Activation and Proliferation in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
SOCS in Negative Feedback Regulation in Myocarditis | |
Atopic Dermatitis | |
T-Cells Differentiation Block in Psoriasis | |
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis | |
Th1-Cell Function in Systemic Lupus Erythematosus | |
Vitiligo | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
Toll-like Receptors in beta-Cell | |
beta-Cell Destruction through Cytokines in Diabetes Mellitus | |
beta-Cell Destruction in Diabetes Mellitus Type 1 | |
Nitric Oxide Effects on beta-Cell | |
Hashimoto's Thyroiditis | |
CD4+T-Cell Response in Celiac Disease | |
Metastatic Colorectal Cancer | |
Th1-Cell Activation in Crohn's Disease | |
Keratinocyte Activation in Psoriatic Arthritis | |
IFNG -> ARRB1/STAT1 Signaling | |
CSF2 -> NF-kB Expression Targets | |
Clozapine Induced Granulocytopenia | |
Myeloid Derived Suppressor Cells in Cancer Immune Escape | |
IDO1 in Cancer Immune Escape | |
IFNG/IFNR Expression Targets | |
Ras-GAP Regulation Signaling | |
TNF -> NF-kB Expression Targets | |
IL1B Expression Targets | |
PPAR Psoriasis | |
IFN signaling in alveolar cells | |
1_Differentiation of psoriatic T cells | |
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
3_Islet beta-cell destruction in T1D | |
Differentiation of psoriatic T cells |
Group | Genes Associated with Systemic Lupus Erythematosus |
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MedScan ID | 3459 |
---|
LocusLink ID | 3459 |
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15979 | |
116465 |
Alias | Ifgr |
---|---|
RP3-503F13.3 | |
OTTHUMP00000017286 | |
OTTHUMP00000017285 | |
Nktar | |
IFN gamma R1 | |
CDw119 | |
interferon gamma receptor 1 | |
IFNGR1 receptor | |
antiviral protein type 2 | |
IFN gamma receptor 1 | |
CD119 | |
INGR_HUMAN | |
IFNGR1 | |
IFN-gamma-R-alpha | |
interferon gamma receptor I | |
receptor IFNGR1 | |
IFNGR I | |
CD119 antigen | |
FLJ45734 | |
Interferon-gamma receptor alpha chain | |
IFN gamma receptor I | |
immune interferon receptor 1 | |
AVP2 | |
gamma interferon receptor 1 | |
LOC360301 | |
IFNGR | |
IMD27A | |
IMD27B | |
AVP, type 2 | |
IFN-gamma receptor 1 | |
IFN-gamma-R1 | |
antiviral protein, type 2 | |
IFN-gammaR | |
INF-g receptor | |
interferon gamma receptor alpha-chain | |
Immune interferon receptors | |
interferon-gamma receptor 1 | |
INGR | |
receptor for immune interferon | |
ifn-gamma r | |
INF-g receptors | |
interferon gamma receptor |
GO ID | 0019955 |
---|---|
0004896 | |
0004906 | |
0048143 | |
0019221 | |
0060333 | |
0001774 | |
1900222 | |
1902004 | |
0010628 | |
1904469 | |
0060334 | |
0009615 | |
0007165 | |
0005887 | |
0005886 | |
0051607 | |
1904783 | |
0030425 | |
0005783 | |
0016021 | |
0016020 | |
0014069 | |
0031982 | |
0042015 | |
0004872 |
KEGG ID | hsa:3459 |
---|---|
mmu:15979 | |
rno:116465 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 10 8.49 cM |
---|---|
10 15.0 cM |
OMIM ID | 107470 |
---|---|
209950 | |
600263 | |
610424 | |
615978 | |
607948 |
Rat chromosome position | 1p12 |
---|
Hugo ID | 5439 |
---|---|
HGNC:5439 |
Human chromosome position | 6q23.3 |
---|
Swiss-Prot Accession | A0A0S2Z3Y2 |
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P15260 | |
P15260.1 | |
P15261 | |
P15261.3 | |
Q9QZ62 | |
B4DFT7 | |
E1P587 | |
Q53Y96 | |
Q91Y85 | |
F5H5M7 | |
Q14936 | |
Q53GX8 | |
Q5TFD1 | |
Q7Z687 | |
Q9BY69 | |
Q3TW49 | |
Q3U8T2 | |
Q540M5 | |
P70599 | |
Q6P6T3 |
PIR ID | A31555 |
---|---|
A34368 |
Swiss-Prot ID | INGR1_HUMAN |
---|---|
INGR1_MOUSE | |
Q91Y85_MOUSE | |
Q9QZ62_RAT | |
Q53Y96_HUMAN |
Cell Localization | Cell membrane |
---|---|
Membrane | |
Plasma membrane |
Ensembl ID | ENSG00000027697 |
---|---|
ENSP00000356713.4 | |
ENST00000367739.8 | |
ENSP00000494069.1 | |
ENST00000646898.1 | |
ENSMUSG00000020009 | |
ENSMUSP00000020188.6 | |
ENSMUST00000020188.12 | |
ENSRNOG00000012074 | |
ENSRNOP00000016286.4 | |
ENSRNOT00000016286.6 | |
ENST00000646036.1 | |
ENST00000644894.1 | |
ENSP00000496387.1 | |
ENSP00000495272.1 | |
ENSRNOP00000016286 | |
ENSMUST00000020188 | |
ENSRNOT00000016286 | |
ENSP00000443282 | |
ENSP00000356713 | |
ENST00000543628 | |
ENST00000367739 | |
ENSMUSP00000020188 |
MGI ID | MGI:107655 |
---|---|
107655 |
RGD ID | 620570 |
---|
Unigene ID | Mm.549 |
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Hs.520414 | |
Rn.19927 |
Homologene ID | 359 |
---|
Shape | Stick-vertex |
---|
IPI ID | IPI00323231 |
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IPI00010808 | |
IPI00129679 | |
IPI00327970 | |
IPI00514230 | |
IPI00514426 |