Protein TRADD

URN urn:agi-llid:8717
Total Entities 0
Connectivity 573
Name TRADD
Description TNFRSF1A-associated via death domain
Notes The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm

Pathway Osteoarthritis
Skin Aging
MTHFR Activity Regulation
mTOR Signaling Hyperfunction
TLR4 Signaling in Leukocytes
Peripheral T-Cell Tolerance
T-Cell Cytotoxic Mediated Cell Death
Necrosis
Leukotriene Effect on Vascular Endothelial Cell Response
Eosinophil Survival by Cytokine Signaling
Macrophage M1 Lineage
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
GFs/TNF -> Ion Channels
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Apoptosis
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Myocardial Infarction
Apoptosis of Myocyte
Inflammatory Reaction in Acne Vulgaris
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Vitiligo
Apoptosis of Melanocyte in Vitiligo
Toll-like Receptors in beta-Cell
Podocyte Dysfunction in Diabetic Nephropathy
Adipose Tissue Inflammation Provokes Insulin Resistance
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Adipokines Production by Adipocyte Impaired in Obesity
Crohn's Disease
Macrophage Dysfunction
T-Cell Cytotoxic Response in Ulcerative Colitis
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
Multiple Myeloma
Eosinophil Survival in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Airway Epithelial Cell Dysfunction
Neutrophil Recruitment in Sinovium in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
Dendritic Cell Dysfunction in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
Skin Fibrosis
Dentin and Enamel Dysruprion in Bloch-Sulzberger Syndrome
Apoptosis Block in Infected Cells
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
TNF Receptor Associated Periodic Syndrome
Osteoclast Activation in Postmenopause
Proteins Involved in Alzheimer's Disease
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Glioblastoma, Mesenchymal Subtype
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
Breast Cancer
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
OPTN Effects on NF-kB Signaling in Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Alveolar Macrophages Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Podocyte Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
TNF-alpha/TNFRSF1A Signaling
NF-kB Canonical Signaling
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNF -> AP-1 Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
TNFRSF6 -> FOXO3A Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF5/6 -> RB1/E2F Signaling
NGFR -> NF-kB Signaling
TNFR -> NF-kB Signaling
NGFR -> MEF Signaling
TNFRSF6 -> DDIT3 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Model of PPARG signaling in psoriasis
1_Inflammation in keratinocytes in the pathology of acne
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Chondrocyte death in osteoarthritis
3_The role of interstitial fibroblasts in pyelonephritis
2_Podocyte dysfunction in glomerulonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Pathogens stimulate mucins expression in the middle ear
2_Cardiomyocyte hypertrophy
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Lipotoxicity in NAFLD
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
2_HIV - induced depletion of CD4+ T-cells
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Neuron and Schwann cell death

MedScan ID 8717

LocusLink ID 8717
71609
246756
22028
101978
110684

Alias TNFR1-associated DEATH domain protein
TNF receptor-associated death domain protein
MGC11078
tumor necrosis factor receptor-1-associated protein
TNF receptor 1 associated signal transducer
9130005N23Rik
Tumor necrosis factor receptor type 1 associated DEATH domain protein
TNF receptor associated death domain protein
AA930854
Hs.89862
tumor necrosis factor receptor associated death domain protein
LOC123915
TRADD
9130005N23
TNFR-associated DD protein
TNFRSF1A-associated via death domain
TNFR-associated DEATH domain protein
tumor necrosis factor receptor type 1-associated DEATH domain protein
tumour necrosis factor receptor associated death domain protein
tumour necrosis factor receptor-1-associated protein
tumour necrosis factor receptor type 1 associated DEATH domain protein
RIKEN cDNA 9130005N23 gene

GO ID 0070513
0019900
0044877
0005068
0005164
0007249
0006919
0006915
0071356
0071550
0097191
0008625
1902042
0043123
0051092
1901224
0043065
0030335
0051798
0050729
0051291
1902041
0010803
0007165
0007169
0033209
0005737
0005856
0005829
0031264
0045121
0005634
0005886
0043235
0060090
0042981
0032991
0032403
0004871
0097296
0010939
0043234
2001239
0097190
0008633
0006917
0008624
0019215
0004872
0042802
0005515
0005123

KEGG ID hsa:8717
mmu:71609
mmu:105242493
rno:246756

MedLine Reference 12143389
10349636
10442092
10702415
11042159
11076861
11217851
11241200
12045187
12466851
12477932
12819136
14730360
15537664
15761471
15782199
16141072
16141073
8565075
8844497
8889548
9620659
9916988
10187805
10400625
10848577
10892748
10911999
11032752
11112773
11435712
11684708
12417987
12446787
12576460
12604596
12665801
12761501
12887920
12911633
14585990
14660619
14702039
16006552
16227624
16344560
16611992
7758105
8612133
8681376
8702708
8934525
8943045
9356494
9427646
9430227
9714541
9916731

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 8 53.04 cM
8 51.0 cM

OMIM ID 603500

Rat chromosome position 19q11

Hugo ID 12030
HGNC:12030

Human chromosome position 16q22.1
16q22

Swiss-Prot Accession Q15628
Q15628.2
B2RRZ7
Q3U0V2
Q3U0V2.1
D3ZZC5
B2RDS3
B3KQZ9
Q52NZ1
Q8K3Z8
TRADD_HUMAN
TRADD_MOUSE
B2RDS3_HUMAN
B2RRZ7_MOUSE

PIR ID A56911

GenBank ID NC_000016
NM_003789
NP_003780
NM_001323552
NP_001310481
XM_005256213
XP_005256270
XM_017023815
XP_016879304
AC074143
AJ307882
AJ311614
CAC38018
AJ311615
AJ311616
AY575851
AAS68637
AY995114
AAX89407
CH471092
EAW83081
HD119556
CBW52910
AK090673
BAG52211
AK301593
BAG63082
AK315654
BAG38020
BC004491
AAH04491
BG717460
BQ707739
BT006934
AAP35580
CA426418
DA353575
L41690
AAA98482
Q15628
NC_000074
NM_001033161
NP_001028333
AC124584
AC124713
CH466525
EDL11255
AK018592
AK156540
BAE33749
AK178733
AK191671
BC028542
AAH28542
BC132607
AAI32608
BC138642
AAI38643
Q3U0V2
NC_005118
XM_006255444
XP_006255506
XM_006255442
XP_006255504
NM_001100480
NP_001093950
AC_000087
AAHX01098146
AC120484
CH473972
EDL92353
AF517017
AAM74196
FQ215613
XM_011523420
XP_011521722
NC_018927
AMYH02032225
DQ893419
ABM84345
DQ896738
ABM87737
AC_000030
AAHY01074160
AC_000148
ABBA01025431
AAHY01074161
AAHY01074162
XM_006255443
XP_006255505
AABR06098507
NT_010498
NW_001838290
NW_926462
NG_009294
AC_000059
NT_078575
NW_001030904
NW_001084744
NW_047535
Q8K3Z8
XM_341671
XP_341672
XM_001071920
XP_001071920
NP_700474
Q52NZ1
AA930854
NM_153425
AA201054
NW_000349
BB749262
AW121848
21668024
81866722
123790740
124376502
74224347
119603487
124000457
13325367
14970570
30582707
45599142
6094511
62632869
74725760
808915

Swiss-Prot ID TRADD_HUMAN
TRADD_MOUSE
D3ZZC5_RAT
B2RRZ7_MOUSE
B2RDS3_HUMAN

Cell Localization Nucleus
Cytoplasm
Cytoskeleton
Cytoplasm, cytoskeleton

Ensembl ID ENSG00000102871
ENSP00000341268.4
ENST00000345057.9
ENSP00000462591.1
ENST00000486556.1
ENSMUSG00000031887
ENSMUSP00000034359.3
ENSMUST00000034359.9
ENSRNOG00000015179
ENSRNOP00000020405.4
ENSRNOT00000020405.6
ENSP00000341268
ENST00000345057
ENSP00000462591
ENST00000486556
ENSMUSP00000034359
ENSMUST00000034359
ENSRNOP00000020405
ENSRNOT00000020405

MGI ID MGI:109200
109200
2142447

RGD ID 621313

Unigene ID Hs.460996
Mm.264255
Rn.18545

Homologene ID 2807

IPI ID IPI00018744
IPI00153113
IPI00202783
IPI00374856
IPI00880652
IPI00880553
IPI00778766

Homo sapiens Chromosome position 16q22

Ensembl Transcript ID ENST00000345057

FunctionalClass death receptor binding
protein binding
identical protein binding
signal transducer

Mus musculus Chromosome position 8 51.0 cM
8

KEGG pathway Adipocytokine signaling pathway
Apoptosis

Rattus norvegicus Chromosome position 19q11

Ensembl Gene ID ENSG00000102871