Protein HBEGF

URN urn:agi-llid:1839
Total Entities 0
Connectivity 2653
Name HBEGF
Description heparin-binding EGF-like growth factor
Notes activates epidermal growth factor receptor mediated signaling; contributes to neuronal survival; may play a role in neurogenesis during ventral midbrain development [RGD, Feb 2006]
Primary Cell Localization Extracellular
Class Ligand

Pathway Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Proteins Involved in Atherosclerosis
Proteins Involved in Hypertrophic Cardiomyopathy
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
Proteins Involved in Diabetic Nephropathy
Cetuximab Resistance in Colorectal Cancer
CagA Phosphorylation Dependent Signaling
Multiple Myeloma
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
Prostate Cancer
Cytokines Trigger Otitis Media
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Blood Vessel
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> STAT Expression Targets
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR -> CTNND Signaling
EGFR/ERBB2 -> TP53 Signaling
EGFR/ERBB2 -> CTNNB Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> ZNF259 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EGFR/ERBB -> STAT Signaling
EREG -> EP300/SP1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
HBEGF -> STAT Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
EGFR Transactivation in Cancer and Non-Cancer Cells
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Epithelial to Mesenchymal Transition in Cancer: Overview
Invadopodia Formation in Cancer Cells
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> STAT Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
GAST Expression Targets in GAST Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
Elevated Receptors -> Expression Targets in Endometrium
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
IL1B Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of body weight
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular leakage
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of tumor aggressiveness
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of pregnancy outcome
Neighbors of fertility
Neighbors of comorbidity
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of body weight
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular leakage
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of tumor aggressiveness
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of pregnancy outcome
Neighbors of fertility
Neighbors of comorbidity
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of cell function
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of leukocyte migration
Neighbors of cell invasion
Neighbors of heart function
Neighbors of lung development
Neighbors of transcription activation
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of hemato-encephalic barrier
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of reperfusion injury
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of death
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of myocardial fibrosis
Neighbors of liver disease
Neighbors of hypertrophy
Neighbors of ovarian cancer
Neighbors of hypertension
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of stromal cell
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of kidney tubule cell
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of lung fibroblast
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of corneal epithelial cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of myofibroblast
Neighbors of mast cell
Neighbors of neuroglia
Neighbors of aortic smooth muscle cell
Neighbors of podocyte
Neighbors of pericyte
Neighbors of epidermis cell
Neighbors of kidney cell
Neighbors of M2 macrophage
Neighbors of lung
Neighbors of kidney
Neighbors of intestine
Neighbors of blood vessel
Neighbors of gastrointestinal tract
Neighbors of placenta
Neighbors of retina
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of glands
Neighbors of eye
Neighbors of cornea
Neighbors of cerebral cortex
Neighbors of bladder
Neighbors of nervous system
Neighbors of blastocyst
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of PKC
Neighbors of mitogen-activated protein kinase
Neighbors of transforming growth factor
Neighbors of cytokine
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of growth factor
Neighbors of PKA
Neighbors of LDL
Neighbors of protein tyrosine kinase
Neighbors of IgG
Neighbors of p38
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of GPCR
Neighbors of Notch
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of Ang II receptor
Neighbors of endothelin
Neighbors of NOS
Neighbors of proteasome endopeptidase complex
Neighbors of non-coding RNA
Neighbors of alpha2 adrenoceptor
Neighbors of phosphoinositide phospholipase C
2_Interleukin-17 and interleukin-22 signaling in psoriasis
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 1839

LocusLink ID 1839
15200
25433

Alias DTSF
LOC225370
proheparin-binding EGF-like growth factor
heparin-binding epidermal growth-like growth factor
GFHB
DTS
heparin-binding epidermal growth factor
AW047313
pro-HB-EGF
pro-heparin-binding EGF-like growth factor
HBGF_HUMAN
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
heparin-binding EGF-like growth factors
DTR
heparin-binding epidermal growth factor-like growth factor
HB-EGF
diphtheria toxin receptor
HEGFL
HBEGF
proHB-EGF
heparin-binding EGF-like growth factor
diphtheria toxin receptors
OTTHUMP00000223860
MGC107656
Diphtheria toxin receptor (heparin-binding EGF-like growth factor)
heparin binding epidermal growth factor-like growth factor
Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
heparin-binding epidermal -growth - like growth factor
heparin-binding epidermal -growth factor
Diphteria toxin receptors
Diphteria toxin receptor

GO ID 0005154
0008083
0008201
0038128
0000165
0060326
0007173
0061024
0007517
0051545
0042059
0030307
0030335
0008284
0051549
0050731
0051897
0048661
0090303
2000145
0008016
0007165
0035313
0009986
0030669
0030665
0030666
0005576
0005615
0005887
0005886
0001525
0001832
0016477
0016021
0016020
0007399
0010469
0005088
0046934
0004713
0018108
0046854
0048015
0043547
0014066
0038095
0008543
0045087
0048011
0009405

KEGG ID hsa:1839
mmu:15200
rno:25433

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 18 19.46 cM

OMIM ID 126150

Rat chromosome position 18p11

Hugo ID 3059
HGNC:3059

Human chromosome position 5q31.3
5q23

Swiss-Prot Accession Q99075
Q99075.1
Q06186
Q5FW64
Q06186.1
Q06175
Q06175.1
B2R821

PIR ID A38432
JC1410
JC1409

GenBank ID NC_000005
NM_001945
NP_001936
AC004634
AAC15470
AY164533
AAN46738
CH471062
EAW62069
GM880654
CAV28318
L17029
AAA50562
L17030
AAA50563
L17031
AAA50564
AK222688
BAD96408
AK307310
AK313202
BAG36018
BC033097
AAH33097
D55114
M60278
AAA35956
Q99075
NC_000084
NM_010415
NP_034545
AC147220
AH006539
AAC42069
AH006744
AAC52617
CH466557
EDK97159
AK052084
AK145548
BAE26501
AK160575
BAE35883
AK164309
BAE37729
AW489543
BC089607
AAH89607
L07264
AAA37542
Q06186
NC_005117
NM_012945
NP_037077
AC_000086
AAHX01094545
AAHX01094546
AAHX01094547
AC097756
CH473974
EDL76294
L05489
AAA81780
Q06175
NC_018916
AMYH02012330
EU832647
ACE87738
EU832724
ACE87056
AC_000040
AAHY01137750
L36024
L36025
L36026
L36027
U39189
U39190
U39191
U39192
AC_000137
ABBA01026434

Swiss-Prot ID HBEGF_HUMAN
HBEGF_MOUSE
HBEGF_RAT

Cell Localization Secreted
Extracellular space
Cell membrane
Secreted, extracellular space

Ensembl ID ENSG00000113070
ENSP00000230990.6
ENST00000230990.7
ENSMUSG00000024486
ENSMUSP00000025363.5
ENSMUST00000025363.6
ENSRNOG00000018646
ENSRNOP00000025157.5
ENSRNOT00000025157.6
ENSP00000230990
ENST00000230990
ENSMUSP00000025363
ENSMUST00000025363
ENSRNOP00000025157
ENSRNOT00000025157

MGI ID MGI:96070

RGD ID 2526

Unigene ID Hs.799
Hs.592942
Mm.289681
Rn.10148

Homologene ID 1466

Shape Rhomb