Protein IRF3

URN urn:agi-llid:3661
Total Entities 0
Connectivity 2133
Name IRF3
Description interferon regulatory factor 3
Notes This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Cortisol in Resolving Inflammation
Antiviral Signaling through Pattern Recognition Receptors
TLR4 Signaling in Leukocytes
Toll-like Receptors in Sterile Inflammation
Macrophage M1 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Dendritic Cells Function in Atherosclerosis
MAVS in Antiviral Innate Immune Response in Myocarditis
Proteins Involved in Myocarditis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Airway Epithelial Cell Dysfunction
Toll-like Receptors (TLR) in Periodontitis
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
TLR3 Role in Retinal Pigment Epithelial Cell
Alveolar Macrophages Dysfunction in COPD
IL15 Expression Targets
TLR3 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR4 -> IRF Signaling
TLR3 -> IRF Signaling
pathway 4
New Pathway (2)
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
sars-cov binding
sars-cov no binding
dsRNA induces innate immunity and INFs in alveolar cells
AGER feed forward loop in innate immunity
Dendritic Cell Activation in COVID19
Overview. Diseases of the genitourinary system (chapter 13)
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D

Group Genes Associated with Systemic Lupus Erythematosus
binding partnetrs for SARSs
other partners for SARS

MedScan ID 3661

LocusLink ID 3661
54131
292892

Alias C920001K05Rik
OTTMUSP00000022257
IRF III
interferon regulatory factor 3
IRF-3
IIAE7
OTTMUSP00000022256
IRF IIIs
C920001K05
interferon regulatory factor III
OTTMUSP00000022258
RIKEN cDNA C920001K05 gene
MGC94729
MGC91046

GO ID 0003677
0001228
0000981
0001227
0000978
0019904
0042803
0043565
0003712
0039530
0035666
0006915
0006974
0071360
0051607
0002376
0060333
0031663
0071888
0000122
0032480
0043123
0050715
0032727
0032728
0045944
0032481
0060340
0097300
0050727
0032479
0006366
0045351
0060337
0016032
0005737
0005829
0005654
0005634
0003700
0044212
0071222
0045087
0050689
0045358
0045893
0010468
0006355
0009617
0043330
0032496
0006917
0034142
0006351
0000975
0002756
0001077
0005515
0019221
0034138
0008063
0001078
0071359
0010008
0019048
0042802
0002224
0003702
0044419
0009615
0005886
0010843
0010553

KEGG ID hsa:3661
mmu:54131
rno:292892

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 7

OMIM ID 603734
616532

Rat chromosome position 1q22

Hugo ID 6118
HGNC:6118

Human chromosome position 19q13.33
19q13.3-q13.4

Swiss-Prot Accession Q14653
E2GIM5
E2GIM7
E2GIM8
E2GIM9
M0QYT9
E2GIM6
Q14653.1
P70671
Q3U9K6
P70671.1
Q5XIB0
A8K7L2
B2RAZ3
Q5FBY1
Q5FBY2
Q5FBY4
Q7Z5G6
Q71U93
Q96GL3
O54726
Q3UJM9

GenBank ID NC_000019
NR_045568
XR_001753678
XR_002958310
XR_002958311
XR_002958312
NM_001197125
NP_001184054
XM_017026767
XP_016882256
XM_006723198
XP_006723261
XM_017026766
XP_016882255
XM_006723197
XP_006723260
NM_001197128
NP_001184057
NM_001197126
NP_001184055
NM_001197127
NP_001184056
NM_001197123
NP_001184052
NM_001197124
NP_001184053
NM_001571
NP_001562
NM_001197122
NP_001184051
XM_024451497
XP_024307265
XM_024451498
XP_024307266
XM_024451495
XP_024307263
XM_024451494
XP_024307262
XM_006723201
XP_006723264
XM_024451496
XP_024307264
XM_024451493
XP_024307261
XM_024451492
XP_024307260
XM_006723200
XP_006723263
NG_031810
AC011495
AF112181
AAD05262
CH471177
EAW52510
EAW52511
EAW52512
EAW52513
U86636
AAC68818
AA568913
AB102884
BAD89413
AB102886
BAD89415
AB102887
BAD89416
AK057577
AK292027
BAF84716
AK314421
BAG37040
BC000660
AAH00660
BC009395
AAH09395
BC071721
AAH71721
BM477213
BP347627
BU859806
CB961512
DA938709
DA999381
HM357932
ADN86147
HM357933
ADN86148
HM357934
ADN86149
HM357935
ADN86150
HM357936
ADN86151
HM357937
ADN86152
Z56281
CAA91227
Q14653
NC_000073
NR_045611
NM_016849
NP_058545
XM_006540995
XP_006541058
XM_006540996
XP_006541059
AC155806
AF036341
AAC68814
CH466603
EDL22782
EDL22783
EDL22784
EDL22785
EDL22786
AK013944
AK050570
AK145977
BAE26800
AK146378
BAE27126
AK151750
BAE30660
AK152689
BAE31420
BC003233
BC023244
BC050882
AAH50882
BY089035
EU545481
ACD67887
U75839
AAB36924
U75840
AAB36925
P70671
NC_005100
XM_006229021
XP_006229083
XM_008759337
XP_008757559
XM_006229022
XP_006229084
XM_006229023
XP_006229085
NM_001006969
NP_001006970
XM_006229024
XP_006229086
AC_000069
AAHX01004996
AC127719
CH473979
EDM07429
EDM07430
EDM07431
EDM07432
BC083776
AAH83776
FQ213393
FQ218848
AAHY01061132
XM_006723199
ABM84381
XR_935819
ABM87305
XR_935820
AC_000029
XR_430199
AC_000151
DQ893455
XM_006723202
NC_018930
DQ896306
AMYH02036325
XP_006723265
ABBA01032913
AABR06004808
XP_006723262
NT_011109
NW_001838497
NW_927240
AC_000062
CR590897
CR596241
CR608119
CR613061
CR613940
CR615920
CR624964
Q5FBY1
Q5FBY2
Q5FBY4
Q71U93
Q7Z5G6
Q96GL3
NT_039424
NW_001030849
O54726
Q3U9K6
Q3UJM9
NW_001084763
NW_047558
Q5XIB0

Swiss-Prot ID IRF3_HUMAN
IRF3_MOUSE
E2GIM8_HUMAN
Q7Z5G6_HUMAN
Q3U9K6_MOUSE
E2GIM7_HUMAN
E2GIM6_HUMAN
Q5XIB0_RAT
E2GIM5_HUMAN
E2GIM9_HUMAN
Q5FBY2_HUMAN
Q5FBY1_HUMAN

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000126456
ENSP00000471896.1
ENST00000601291.5
ENSP00000471358.1
ENST00000599223.5
ENSP00000366339.5
ENST00000377135.8
ENSP00000470069.1
ENST00000599144.5
ENSP00000472700.1
ENST00000600022.5
ENSP00000470512.1
ENST00000596765.5
ENSP00000366344.3
ENST00000377139.8
ENSP00000310127.6
ENST00000309877.11
ENSP00000470431.1
ENST00000600911.5
ENSP00000469113.1
ENST00000597198.5
ENSP00000472582.1
ENST00000598808.5
ENSMUSG00000003184
ENSMUSP00000003284.8
ENSMUST00000003284.15
ENSMUSP00000146773.1
ENSMUST00000209066.1
ENSMUSP00000103465.1
ENSMUST00000107834.1
ENSRNOG00000043388
ENSRNOP00000027786.4
ENSRNOT00000027786.6
ENST00000596765
ENSRNOP00000027786
ENSMUSP00000003284
ENST00000600022
ENSP00000471358
ENSP00000472601
ENSP00000470069
ENSMUST00000107835
ENSMUST00000107834
ENSP00000366344
ENSMUSP00000103466
ENSMUSP00000103465
ENST00000377135
ENST00000597636
ENSP00000472582
ENST00000377139
ENSRNOT00000027786
ENSMUST00000003284
ENST00000598808
ENSP00000472700
ENSP00000471896
ENSP00000366339
ENST00000309877
ENST00000377139.7
ENST00000601291
ENSMUST00000209066
ENST00000599144
ENSP00000310127
ENST00000599223
ENSMUSP00000146773
ENST00000593922
ENSP00000470512

MGI ID MGI:1859179
1859179

RGD ID 1549774

Unigene ID Hs.75254
Hs.731922
Mm.489648
Rn.1499
Hs.289052
Mm.3960

Homologene ID 1208

Shape O-vertex

IPI ID IPI00111836
IPI00291901
IPI00737251
IPI00646709
IPI00976695
IPI00364320
IPI00941119
IPI00873861