Protein IL12A

URN urn:agi-llid:3592
Total Entities 0
Connectivity 872
Name IL12A
Description interleukin 12A
Notes This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand

Pathway Toll-like Receptors Act through MYD88-TIRAP Signaling
Dectin-1 (CLEC7A) Signaling
DCIR1 (CLEC4A) Signaling
TLR4 Signaling in Leukocytes
CD8+ T-Cell Activation
Th1-Cell Differentiation
Toll-like Receptors in Sterile Inflammation
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Macrophage M1 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Lymphocyte Mediated Myocardial Injury in Myocarditis
Inflammatory Reaction in Acne Vulgaris
Atopic Dermatitis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
CD4+T-Cell Response in Celiac Disease
Crohn's Disease
Th1-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Dendritic Cell Function in Ulcerative Colitis
Il17 Signaling Related Neutrophilia in Asthma
Dendritic Cell Dysfunction in Psoriatic Arthritis
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Immune System Role in Otitis Media
Proteins Involved in Chronic Obstructive Pulmonary Disease
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
Myeloid Derived Suppressor Cells in Cancer Immune Escape
EGFR -> Expression Targets in Skin
IFNG/IFNR Expression Targets
IL23R -> STAT3/NF-kB Signaling
C5AR1 -> Expression Targets in Lymphoid System and Blood
TLR3 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
Model of PPARG related pathways in psoriasis (short version)
1_Inflammation in keratinocytes in the pathology of acne
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Defective tolerance of autoreactive T-cell in T1D

MedScan ID 3592

LocusLink ID 3592
16159
84405

Alias MGC151232
cytotoxiclymphocyte maturating factor 1, p35
cytotoxic lymphocyte maturation factor I
natural killer cell stimulatory factor 1
Interleukin-12 alpha
interleukin IL-12, subunit p35
cytotoxiclymphocyte maturation factor 1, p35
NF cell stimulatory factor chain I
CLMF P35
NKSF1
Ll12a
Interleukin IL12A
NK cell stimulatory factor chain I
IL-12p35
Cytotoxic lymphocyte maturating factor 35 kDa subunit
interleukin 12 p35 subunit
interleukin 12A
Interleukin IL12 alpha
natural killer cell stimulatory factor 1, 35 kD subunit
IL-12-specific subunit p35
interleukin 12a p35 subunit
IL-12 p35 subunit
cytotoxic lymphocyte maturation factor 1
MGC151228
cytotoxic lymphocyte maturation factor 1, p
interleukin 12 alpha subunit
interleukin 12 subunit p35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lympho
cytotoxic lymphocyte maturation factor 1, p35
OTTHUMP00000213704
cytotoxic lymphocyte maturating factor 1
natural killer cell stimulatory factor I
interleukin IL-12p35
NF cell stimulatory factor chain 1
I12A_HUMAN
interleukin-12 subunit alpha
IL-12, subunit p35
cytotoxic lymphocyte maturating factor 1, p35
NFSK
interleukin IL-12-specific subunit p35
cytotoxic lymphocyte maturating factor I
CLMF
NK cell stimulatory factor chain 1
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Cytotoxic lymphocyte maturation factor 35 kDa subunit
NKSF I
OTTHUMP00000213705
interleukin 12, p
IL12A
interleukin 12, p35
P35
IL-12A
IL35 subunit
interleukin-12 alpha chain
IL-12 subunit p35
interleukin-12 p35 subunit

GO ID 0005125
0008083
0042163
0005143
0045513
0046982
0035711
0035744
0007050
0016477
0008283
0071222
0098586
0019221
0050830
0042832
0097191
0006955
0035722
0070757
0032700
0048662
0051135
0045582
0001916
0042102
0045785
2000510
0032729
0050671
0032946
0032816
0045954
0002860
0034393
0042531
0010224
0032496
0009615
0009986
0005788
0005576
0005615
0043514
0031906
0005737
0032609
0010469
0042520

KEGG ID mmu:16159
rno:84405
hsa:3592

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 3 31.92 cM
3 37.0 cM

OMIM ID 161560

Rat chromosome position 2q32
2q31

Hugo ID 5969
HGNC:5969

Human chromosome position 3q25.33
3q25.33-q26

Swiss-Prot Accession O60595
P29459
P29459.2
F8WI71
P43431
Q549G3
P43431.1
Q9R103
Q9R103.1
Q96QZ1
E9PGR3
Q7LDP2
Q9QUT1
E9QP58

PIR ID I56135
B38957

GenBank ID NC_000003
NM_000882
NP_000873
NM_001354582
NP_001341511
NM_001354583
NP_001341512
NG_033022
AC010370
AF050083
AAC05211
AAC05212
AF404773
AAK84425
CH471052
EAW78656
EAW78657
EAW78658
CS498405
CAM82732
HH821934
CBX32667
JA104599
CCA63969
AF101062
AAD16432
AF180562
AAD56385
AW472810
BC035571
BC104982
AAI04983
BC104984
AAI04985
BG702253
M65271
AAA35694
M65291
AAA59937
P29459
NC_000069
NM_001159424
NP_001152896
NM_008351
NP_032377
XM_006501044
XP_006501107
AC121306
AH004858
AAB37382
CH466547
EDL15506
EDL15507
EDL15508
D63334
BAA09647
AF128210
AAF22551
AF128211
AAF22552
AF128212
AAF22553
AF128213
AAF22554
AK153729
AV363060
BC116851
AAI16852
BC116855
AAI16856
M86672
AAA39292
P43431
NC_005101
NM_053390
NP_445842
AC_000070
AABR07011640
AABR07011641
AAHX01017684
AAHX01017685
CH473976
EDM00915
EDM00916
AF177031
AAD51364
Q9R103
NC_018914
AMYH02008013
AC_000025
AAHY01027630
BC141596
AAI41597
BC146595
AAI46596
XM_005247435
XP_005247492
AC_000135
ABBA01058801
S82412
S82414
S82417
S82418
S82419
NT_005612
NW_001838884
NW_921807
AC_000046
Q7LDP2
NT_039240
NW_001030721
Q549G3
Q9QUT1
NW_047625
NW_001084805

Swiss-Prot ID IL12A_MOUSE
IL12A_RAT
IL12A_HUMAN
E9QP58_MOUSE
Q549G3_MOUSE
O60595_HUMAN

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000168811
ENSP00000303231.2
ENST00000305579.7
ENSP00000419046.1
ENST00000466512.1
ENSP00000420184.1
ENST00000480787.5
ENSMUSG00000027776
ENSMUSP00000029345.5
ENSMUST00000029345.11
ENSMUSP00000103446.2
ENSMUST00000107816.3
ENSRNOG00000009468
ENSRNOP00000012832.1
ENSRNOT00000012831.3
ENSP00000303231
ENST00000305579
ENSMUSP00000029345
ENSMUST00000029345
ENSMUSP00000103446
ENSMUST00000107816
ENSRNOP00000012832
ENSRNOT00000012831
ENSP00000419046
ENST00000466512

MGI ID MGI:96539
96539

RGD ID 620562

Unigene ID Hs.673
Mm.103783
Rn.207199

Homologene ID 681

Shape Rhomb

IPI ID IPI00120355
IPI00206535
IPI00182737
IPI00929795
IPI00796173
IPI00475347