Protein MAPK10

URN urn:agi-llid:5602
Total Entities 0
Connectivity 1180
Name MAPK10
Description mitogen-activated protein kinase 10
Notes The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Osteoarthritis
Skin Aging
Dopamine Receptors Signaling
Vascular Endothelial Cell Activation by Cytokines
Nociception Expression Targets Signaling
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
Dendritic Cells Function in Atherosclerosis
Myocardial Infarction
Inflammatory Reaction in Acne Vulgaris
IL17 Signaling in Psoriasis
Dendritic Cells Function in Psoriasis
OipA Signaling in Helicobacter Pylori Infection
Osteoclast Activation in Multiple Myeloma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Skin Fibrosis
CCR5 Signaling in Macrophages
Glioma Invasion Signaling
WNT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
Steroids Induced Cataract
Cytokines Trigger Otitis Media
WNT Signaling in Cystic Kidney Disease
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> AP-1 Expression Targets
Dopamine/Gi Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
AGTR1 -> ARRB1/ARRB2 Signaling
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB2 -> TP53 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FrizzledR -> JUN/PAX2 Signaling
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Apoptosis Block by BCL2 Family Proteins in Cancer
VEGFA Dependent Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
S1P Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
EDN1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
AngiopoietinR -> AP-1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TGFBR -> AP-1 Signaling
TNF-alpha/TNFRSF1A Signaling
JNK/MAPK Signaling
VEGF Signaling
EGFR Signaling
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
TGFA -> TP53 Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
TLR9 Expression Targets
TLR -> AP-1 Signaling
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
WNT1 Expression Targets
WNT3A Expression Targets
WNT4 Expression Targets
WNT5A Expression Targets
WNT7A Expression Targets
1_Inflammation in keratinocytes in the pathology of acne
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
2_Neuron and Schwann cell death
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes Associated with in Epileptic Encephalopathies

MedScan ID 5602

LocusLink ID 5602
26414
25272

Alias JNK3 alpha protein kinase
c-Jun kinase 3
p54b SAPK
stress activated protein kinase JNK3
mitogen activated protein kinase 10
OTTMUSP00000018410
SAPK/Erk/kinase II
FLJ12099
C230008H04
OTTHUMP00000161181
FLJ33785
c-Jun N-terminal kinase 3
protein kinase mitogen-activated 10
SAPK1b
Serk2
JNK3 beta1 protein kinase
C230008H04Rik
OTTHUMP00000161180
JNK3 alpha2 protein kinase
JNK3
JNK3A2
SAPb
RIKEN cDNA C230008H04 gene
OTTMUSP00000018411
p54-beta
c-Jun N-terminal kinase III
stress-activated protein kinase 1b
SAPKC
stress activated protein kinase beta
MAPK10
MK10_HUMAN
p54bSAPK
MAP kinase p49 3F12
JNK3B2
p49JNK3
JNK3 beta2 protein kinase
p49SAPK
MK10
p49MAPK
MGC50974
OTTMUSP00000018409
c-Jun kinase III
MAP kinase 10
SAPK/Erk/kinase 2
OTTMUSP00000018412
OTTMUSP00000017557
RP13-514E23.1
JNK3A
OTTHUMP00000161182
p493F12
OTTHUMP00000161183
JNK3B1
kinase alpha-2
SAPK(beta)
PRKM10
stress-activated protein kinase JNK3
mitogen-activated protein kinase 10
MAPK 10
SAPK-beta

EC Number 2.7.11.24

GO ID 0005524
0004705
0004707
0004708
0038095
0007254
0007258
0000187
0071474
0071310
0035556
0000122
0098969
0006468
0051090
0042752
0010468
0009416
0009414
0048511
0007165
0099003
0005737
0005829
0098978
0005739
0043005
0005654
0005634
0043204
0005886
0016301
0000166
0004672
0004674
0016740
0045475
0016310
0016020
0014069
0000165
0097481
0005622
0002755
0002756
0035666
0045087
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0016772

KEGG ID hsa:5602
mmu:26414
rno:25272

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 5

OMIM ID 602897

Rat chromosome position 14p22

Hugo ID 6872
HGNC:6872

Human chromosome position 4q21.3
4q22.1-q23

Swiss-Prot Accession A0A286YF97
P53779
Q499Y8
A8MWW6
A0A286YFD7
I6L9F3
A0A1P0B7D2
D6RJF9
A0A286YEQ7
A0A286YFN2
A0A286YES0
A0A286YF02
D6RCB1
P53779.2
Q78GB8
Q8C9D4
Q80W80
Q61831
Q3TQZ7
Q80W81
Q80W82
Q61831.2
A0A0U1RVI2
B0VXR6
P49187
P49187.3
A6NFS3
A6NG28
B3KQ94
Q15707
Q49AP1
Q9R0U6
D3ZQ33
P49187.2

PIR ID S71104
S43969

GenBank ID NC_000004
XR_001741289
NM_138982
NP_620448
NM_001318069
NP_001304998
NM_001351624
NP_001338553
NM_138980
NP_620446
NM_002753
NP_002744
NM_001351625
NP_001338554
NM_001363657
NP_001350586
NM_001318068
NP_001304997
NM_001318067
NP_001304996
XM_024454141
XP_024309909
XM_017008428
XP_016863917
XM_011532120
XP_011530422
XM_024454142
XP_024309910
XM_024454145
XP_024309913
XM_011532117
XP_011530419
XM_024454144
XP_024309912
XM_024454140
XP_024309908
XM_024454148
XP_024309916
XM_024454139
XP_024309907
XM_017008448
XP_016863937
XM_005263131
XP_005263188
XM_006714269
XP_006714332
XM_005263135
XP_005263192
XM_017008434
XP_016863923
XM_017008450
XP_016863939
XM_017008433
XP_016863922
XM_017008441
XP_016863930
XM_017008427
XP_016863916
XM_017008445
XP_016863934
XM_017008451
XP_016863940
XM_017008449
XP_016863938
XM_017008447
XP_016863936
XM_017008452
XP_016863941
XM_017008420
XP_016863909
XM_006714268
XP_006714331
XM_017008435
XP_016863924
XM_017008429
XP_016863918
XM_005263129
XP_005263186
XM_017008430
XP_016863919
XM_017008423
XP_016863912
XM_017008436
XP_016863925
XM_011532118
XP_011530420
XM_024454146
XP_024309914
XM_011532121
XP_011530423
XM_017008437
XP_016863926
XM_005263130
XP_005263187
XM_017008432
XP_016863921
XM_024454143
XP_024309911
XM_024454147
XP_024309915
XM_017008422
XP_016863911
XM_017008454
XP_016863943
XM_024454149
XP_024309917
XM_017008453
XP_016863942
NG_013325
AC096953
AC104059
AC104827
AC108054
AC110076
AX027293
CAC09125
AX027295
CAC09126
CH471057
EAX05962
EAX05963
CS693282
CAP12256
CS693286
CAP12257
CS693290
CAP12259
KT585173
AF052141
AK022161
AK057723
BAG51956
AK091104
BAG52284
AK124791
BAG54096
AK225974
AK294125
BAH11677
AK307129
BC022492
BC035057
AAH35057
BC051731
AAH51731
BC065516
AAH65516
BI549234
CB069160
DA192997
U07620
AAC50101
U34819
AAC50604
U34820
AAC50605
P53779
NC_000071
NM_001081567
NP_001075036
NM_001318102
NP_001305031
NM_009158
NP_033184
NM_001310683
NP_001297612
NM_001310685
NP_001297614
NM_001318131
NP_001305060
NM_001310686
NP_001297615
XM_017320890
XP_017176379
XM_006534950
XP_006535013
XM_017320886
XP_017176375
XM_017320891
XP_017176380
XM_017320889
XP_017176378
XM_017320888
XP_017176377
XM_011249450
XP_011247752
AC123664
AC125252
AC137121
AC160244
CH466529
EDL20250
EDL20251
EDL20252
AB005665
BAA85877
AB096076
BAC76450
AB096077
BAC76451
AB096078
BAC76452
AB096079
BAC76453
AK036275
AK042368
BAC31240
AK046409
BAC32713
AK048693
AK076990
AK082242
AK082729
AK136881
AK163206
BAE37234
AK163385
BC046625
AAH46625
CA751768
L35236
AAB37741
Q61831
NC_005113
XM_017599079
XP_017454568
XM_017599080
XP_017454569
XM_017599082
XP_017454571
XM_017599084
XP_017454573
XM_017599083
XP_017454572
NM_012806
NP_036938
NM_001270556
NP_001257485
NM_001318190
NP_001305119
XM_017599081
XP_017454570
AC_000082
AABR07014301
AABR07072369
AAHX01077960
AAHX01077961
AAHX01077962
AAHX01077963
AAHX01077964
AAHX01077965
AAHX01077966
AAHX01077967
AAHX01077968
AAHX01077969
AAHX01077970
AAHX01077971
AAHX01077972
AAHX01077973
AAHX01077974
AAHX01077975
AC141145
CH474022
EDL99526
EDL99527
CS693293
CAP12261
DQ377224
ABD24063
FQ083521
FQ084081
FQ211777
L27128
AAA42110
P49187
XM_011532119
XP_011530421
XM_011532122
XP_011530424
XM_005263136
XP_005263193
NM_138981
NP_620447
XM_011532123
XP_011530425
XM_006714272
XP_006714335
XM_006714271
XP_006714334
NC_018915
AMYH02009652
AMYH02009653
AMYH02009654
AMYH02009655
HG497056
XM_006534946
XP_006535009
XM_006534951
XP_006535014
XM_006534949
XP_006535012
XM_011249449
XP_011247751
AC_000027
AAHY01047444
AAHY01047445
AAHY01047446
AAHY01047447
AAHY01047448
AAHY01047449
AAHY01047450
AAHY01047451
AAHY01047452
AAHY01047453
AAHY01047454
BC026697
XM_008769992
XP_008768214
XM_006714267
XP_006714330
XM_006714270
XP_006714333
XM_005263138
XP_005263195
AC_000136
ABBA01063498
ABBA01063499
ABBA01063500
XM_006534944
XP_006535007
XM_006534943
XP_006535006
XM_006534947
XP_006535010
XM_006534945
XP_006535008
XM_006534948
XP_006535011
XM_006534952
XP_006535015

Swiss-Prot ID MK10_HUMAN
MK10_MOUSE
MK10_RAT

Cell Localization Cytoplasm
Membrane
Nucleus
Mitochondrion

Ensembl ID ENSG00000109339
ENSP00000493344.1
ENST00000641718.1
ENSP00000414469.2
ENST00000449047.6
ENSP00000493040.1
ENST00000642015.1
ENSP00000493237.1
ENST00000641170.1
ENSP00000491866.1
ENST00000638225.1
ENSP00000493435.1
ENST00000641462.2
ENSP00000493275.1
ENST00000641051.1
ENSP00000493177.1
ENST00000641737.1
ENSP00000493363.1
ENST00000641157.1
ENSP00000493270.1
ENST00000641050.1
ENSP00000493013.1
ENST00000641952.1
ENSP00000492913.1
ENST00000641553.1
ENSP00000378598.5
ENST00000395169.9
ENSP00000378586.4
ENST00000395157.9
ENSP00000352157.4
ENST00000359221.8
ENSP00000492898.1
ENST00000641384.1
ENSP00000493447.1
ENST00000642023.1
ENSP00000493350.1
ENST00000641166.1
ENSP00000492920.1
ENST00000641607.1
ENSP00000493455.1
ENST00000641047.1
ENSP00000492912.1
ENST00000641881.1
ENSP00000493045.1
ENST00000641983.1
ENSP00000493049.1
ENST00000641803.1
ENSP00000425654.2
ENST00000512689.6
ENSP00000491122.1
ENST00000640858.1
ENSP00000493072.1
ENST00000641066.1
ENSP00000492231.1
ENST00000640970.1
ENSP00000378595.1
ENST00000395166.6
ENSP00000493206.1
ENST00000641989.1
ENSP00000492292.1
ENST00000638313.1
ENSP00000492942.1
ENST00000642038.1
ENSP00000491089.1
ENST00000639242.1
ENSP00000493309.1
ENST00000641767.1
ENSP00000493396.1
ENST00000641862.1
ENSP00000422277.2
ENST00000511167.6
ENSMUSG00000046709
ENSMUSP00000108468.2
ENSMUST00000112847.8
ENSMUSP00000084065.3
ENSMUST00000086854.9
ENSMUSP00000127193.1
ENSMUST00000170792.7
ENSRNOG00000002079
ENSRNOP00000060904.4
ENSRNOT00000065965.4
ENSRNOP00000075846.1
ENSRNOT00000092395.1
ENSP00000355297
ENST00000361569
ENSP00000378598
ENST00000395169
ENSP00000352157
ENST00000359221
ENSP00000378590
ENST00000395161
ENSP00000378586
ENST00000395157
ENSMUSP00000108468
ENSMUST00000112847
ENSMUSP00000127193
ENSMUST00000170792
ENSMUSP00000084065
ENSMUST00000086854
ENSRNOP00000060904
ENSRNOT00000065965
ENSRNOP00000075846
ENSRNOT00000092395

MGI ID MGI:1346863

RGD ID 3663

Unigene ID Hs.13438
Hs.125503
Mm.39253
Mm.472459
Rn.9911

Homologene ID 56439

Shape Sickle-vertex