Pathway
|
Osteoarthritis
|
|
Skin Aging
|
|
Melatonin Effects on Circadian Cycle
|
|
Dopamine Receptors Signaling
|
|
Serotonin Receptors Signaling
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Maturation (Hypothesis)
|
|
Th17-Cell Differentiation
|
|
Plasmin Effects in Inflammation
|
|
Platelet Activation via Adhesion Molecules
|
|
Scavenger Receptors in Platelet Activation
|
|
Bradykinin Effects in Inflammation
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
MC1R in anti-Inflammatory Signaling
|
|
Leukotriene Effect on Vascular Endothelial Cell Response
|
|
Leukotriene Effect on Airway Smooth Muscle Response
|
|
Basophil Activation
|
|
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cell Activation without Degranulation
|
|
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
|
|
Macrophage M1 Lineage
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
Neutrophil Recruitment and Priming
|
|
Neutrophil Degranulation via FPR1 Signaling
|
|
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
|
|
Vascular Endothelial Cell Activation by Cytokines
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Nociception Expression Targets Signaling
|
|
EDNRA/B -> Vascular Motility
|
|
ADRA1A -> IL6 Production
|
|
ADRA1 -> Prostaglandin Generation
|
|
BDKRB1/2 -> Prostaglandin Generation
|
|
CNR1/2 -> IL1B/2/4/6/10 Production
|
|
DRD2 Expression Targets
|
|
CHRM1 -> IL2 Production
|
|
PTGER2/3 -> Inflammation-Related Expression Targets
|
|
HTR1 -> IL6 Production
|
|
HTR5 -> TNF Production
|
|
HTR1 -> Membrane Transport
|
|
IL1B Expression Targets -> Nociception
|
|
Melatonin in Cell Survival and Antioxidant Response
|
|
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
|
|
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
Sebocyte Proliferation in Acne Vulgaris
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Keratinocyte Proliferation in Acne Vulgaris
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
IL17 Signaling in Psoriasis
|
|
T-Cells Differentiation Block in Psoriasis
|
|
Th17-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Apoptosis of Melanocyte in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
Toll-like Receptors in beta-Cell
|
|
Proteins Involved in Diabetes Mellitus Type 2
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
Microangiopathy in Diabetic Neuropathy
|
|
Insulin Resistance in Hepatocytes
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
|
|
Hypoparathyroidism, Primary
|
|
CD4+T-Cell Response in Celiac Disease
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
Antiphospholipid Antibodies in Endothelial Cell
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Proteins Involved in Chronic Myeloid Leukemia
|
|
Follicular Lymphoma
|
|
Osteoclast Activation in Multiple Myeloma
|
|
Multiple Myeloma
|
|
Antiphospholipid Antibodies and Endothelial Cell Interaction
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
IL33 Signaling Related Eosinophilia in Asthma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Basophil Activation in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Th17-Cell Differentiation in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
|
|
Osteoclast Activation in Gout
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
IL1B Induced Arthralgia
|
|
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
|
|
Synovial Fibroblast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
|
|
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
|
|
B-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
Dentin Formation Disruption
|
|
CCR5 Signaling in Macrophages
|
|
Th17-Cell Numbers Reduction in HIV
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
|
|
Osteoclast Activation in Postmenopause
|
|
Synaptic Exocytosis in Dementia
|
|
Glioma Invasion Signaling
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
Microglia and Motor Neuron Interaction Dysregulation
|
|
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
|
|
WNT Signaling in Breast Cancer
|
|
Angiogenesis in Endometriosis
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
Prostate Cancer
|
|
VEGFA in Neovascular Glaucoma
|
|
Cytokines Trigger Otitis Media
|
|
MUC5AC Expression by NTHi and S. Pneumoniae
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
WNT Signaling in Cystic Kidney Disease
|
|
Polycystins Mutation Effects in Cystic Kidney Disease
|
|
Plasmin Role in Glomerulonephritis
|
|
Mesangial Cell Dysfunction in Glomerulonephritis
|
|
Interstitial Fibroblasts in Pyelonephritis
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
S100P Expression Target
|
|
HMGB1 Expression Targets
|
|
TTR Expression Targets
|
|
S100A Expression Targets
|
|
S100B Expression Targets
|
|
ANGPT1 -> CREB/CREBBP Expression Targets
|
|
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
|
|
AREG -> NFATC Expression Target
|
|
AREG -> CREB/CREBBP Expression Targets
|
|
AREG -> NCOR2 Expression Targets
|
|
AREG -> AP-1 Expression Targets
|
|
Acetylcholine Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
BTC -> NFATC Expression Targets
|
|
BTC -> AP-1/ATF/CREB Expression Targets
|
|
Frizzled Receptors -> ARRB1/ARRB2 non-Canonical Signaling
|
|
CD72 -> NF-kB Expression Targets
|
|
CD8 -> NF-kB Expression Targets
|
|
CD80 -> NFATC Expression Targets
|
|
CD86 -> NFATC Expression Targets
|
|
Complement Component GPCRs Signaling
|
|
Clozapine Induced Granulocytopenia
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
EGF -> MEF/MYOD/NFATC Expression Targets
|
|
EGF -> TP53 Expression Targets
|
|
EGF -> NCOR2 Expression Target
|
|
EGFR -> NCOR2 Signaling
|
|
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
|
|
EGFR/ERBB2 -> TP53 Signaling
|
|
EGFR -> AP-1/ATF2 Signaling
|
|
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
|
|
EREG -> CREB Expression Target
|
|
EREG -> AP-1/ATF Expression Targets
|
|
Erythropoietin -> AP-1/MYC/CREB Expression Targets
|
|
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
FGF9 -> AP-1/CREB/MYC Expression Targets
|
|
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
FGF1 -> NCOR2 Expression Target
|
|
FGF8 -> AP-1/CREB/MYC Expression Targets
|
|
FGF18 -> AP-1/CREB Expression Targets
|
|
FGF23 -> NCOR2 Expression Targets
|
|
FGF2 -> NCOR2 Expression Targets
|
|
FGF4 -> AP-1/MYC Expression Targets
|
|
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
|
|
FrizzledR -> JUN/PAX2 Signaling
|
|
ADCYAP1 Expression Targets
|
|
Glutamate/Gq Expression Targets
|
|
VIP Expression Targets
|
|
HBEGF -> AP-1/ATF Expression Targets
|
|
HBEGF -> TP53 Expression Targets
|
|
HBEGF -> MEF/MYOD Expression Target
|
|
HBEGF -> CREB/MYC Expression Targets
|
|
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
HGFR -> AP-1/CREB/MYC Signaling
|
|
TAM Receptor Signaling Activation in Cancer
|
|
RAS/RAF/MAPK Signaling Activation in Cancer
|
|
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
|
|
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
VEGFA Dependent Angiogenesis in Cancer
|
|
Inhibition of THBS1 Activates Angiogenesis in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
|
|
CDH2 Activation Promotes Cancer Cell Migration and Survival
|
|
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
|
|
IGF1 -> MEF/MYOD/MYOG Expression Targets
|
|
IGF2/MEF/MYOD Expression Targets
|
|
Insulin -> MEF/MYOD Expression Targets
|
|
AGER -> CREB/SP1 Signaling
|
|
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
|
|
IGF1R -> MEF/MYOD/MYOG Signaling
|
|
FibronectinR -> NF-kB Signaling
|
|
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
|
|
Fibronectin Expression Targets
|
|
CTGF -> AP-1/CREB/MYC Expression Targets
|
|
CTGF -> NCOR2 Expression Target
|
|
ICAM1 Expression Targets
|
|
IL1R -> STAT3 Signaling
|
|
IL1R -> NF-kB Signaling
|
|
IL16-> ATF/CREB/CREBBP Expression Target
|
|
LPA Expression Targets
|
|
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
|
|
Dronabinol/Anandamide Expression Targets
|
|
PAF/Gq -> NF-kB Expression Targets
|
|
S1P Expression Targets
|
|
MTNR1 Signaling
|
|
NRG1 -> MEF/MYOD Expression Targets
|
|
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
NRG1 -> TP53 Expression Target
|
|
NRG1 -> AP-1/ATF Expression Targets
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
NGF -> AP-1/TP53/MYC Expression Targets
|
|
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
NGF -> CREB/CEBPB/MEF2A Expression Targets
|
|
NOTCH -> TCF3 Signaling
|
|
NOTCH Expression Targets
|
|
PDGFB -> AP-1/CREB/MYC Expression Target
|
|
PDGFC -> CREB Expression Target
|
|
PDGFD -> AP-1 Expression Targets
|
|
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
KIT -> MITF Signaling
|
|
PDGFR -> AP-1/MYC Signaling
|
|
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
GNRH1 Expression Targets
|
|
GNRH2 Expression Targets
|
|
EDN1 Expression Targets
|
|
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
|
|
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
|
|
EDN3 Expression Targets
|
|
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
PDCD1 -> ATF/CREB/CREBBP Expression Targets
|
|
AngiopoietinR -> AP-1 Signaling
|
|
GDNF -> HSF1 Signaling
|
|
EphrinB -> MAPK/JUN/FOS Signaling
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
GAS6 -> AP-1/CREB Expression Targets
|
|
FIGF -> AP-1 Expression Target
|
|
FIGF -> NCOR2 Expression Target
|
|
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
GDNF -> HSF1 Expression Targets
|
|
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
|
|
TNF-alpha/TNFRSF1A Signaling
|
|
JNK/MAPK Signaling
|
|
MERTK Signaling
|
|
Ras Signaling
|
|
TGF-beta Signaling
|
|
P38 MAPK/MAPK14 Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
PI3K/RAC1 Signaling
|
|
VEGF Signaling
|
|
EGFR Signaling
|
|
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
|
|
ERK/MAPK Canonical Signaling
|
|
TCR -> CREB/CREBBP/ATF Expression Targets
|
|
T-Cell Receptor -> ATF/CREB Signaling
|
|
TGFA -> TP53 Expression Targets
|
|
TGFA -> MEF/MYOD/NFATC Expression Targets
|
|
TGFA/AP-1/ATF Expression Targets
|
|
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
|
|
FASLG Expression Targets
|
|
TNFSF10 Expression Targets
|
|
LTA Expression Targets
|
|
TNFSF14 Expression Targets
|
|
TNF -> AP-1 Expression Targets
|
|
CD72 -> AP-1 Expression Targets
|
|
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
|
|
TNFSF13 Expression Targets
|
|
TNFSF13B Expression Targets
|
|
TNF -> ELK-SRF Expression Targets
|
|
TNF -> CREB Expression Targets
|
|
TNF -> TP53/ATF Expression Targets
|
|
EDA Expression Targets
|
|
EctodysplasinR -> AP-1 Signaling
|
|
TNFR -> CREB/ELK-SRF Signaling
|
|
TNFR -> AP-1/ATF/TP53 Signaling
|
|
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
|
|
TNFRSF5/6 -> RB1/E2F Signaling
|
|
NGFR -> MEF Signaling
|
|
TNFRSF6 -> DDIT3 Signaling
|
|
TNFRSF6 -> HSF1 Signaling
|
|
TNFRSF1A -> AP-1/ATF/TP53 Signaling
|
|
TNFRSF1A -> CREB/ELK-SRF Signaling
|
|
Thrombopoietin -> SPI1 Expression Targets
|
|
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
IL1B -> PGE2 Expression Targets
|
|
IL1B Expression Targets
|
|
IL1A Expression Targets
|
|
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
|
|
VEGFA -> NFATC Expression Targets
|
|
VEGFC -> ATF Expression Target
|
|
VEGFA -> AP-1/CREBBP/MYC Expression Targets
|
|
VEGFA -> NCOR2 Expression Target
|
|
VEGFR -> NFATC Signaling
|
|
VEGFR -> AP-1/CREB/MYC Signaling
|
|
VEGFR -> ATF/CREB/ELK-SRF Signaling
|
|
WNT1 Expression Targets
|
|
WNT3A Expression Targets
|
|
WNT4 Expression Targets
|
|
WNT5A Expression Targets
|
|
WNT7A Expression Targets
|
|
ace2
|
|
PPAR Psoriasis
|
|
Model of PPARG signaling in psoriasis
|
|
PPARG negative regulators and targets
|
|
Model of PPARG related pathways in psoriasis (short version)
|
|
1_Inflammation in keratinocytes in the pathology of acne
|
|
2_Acute phase initiation in atopic dermatitis
|
|
1_Differentiation of psoriatic T cells
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
1_TNF and IL1B provoke ECM degradation in osteoarthritis
|
|
1_Osteoclast-mediated bone resorption in postmenopausal women
|
|
1_Formation of cysts in polycystic kidney disease
|
|
3_The role of interstitial fibroblasts in pyelonephritis
|
|
3_Enhanced angiogenesis in endometriosis
|
|
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
|
|
2_Pathogens stimulate mucins expression in the middle ear
|
|
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
|
|
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
|
|
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
|
|
4_1_Polymorphisms associated with inflammatory bowel diseases
|
|
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
|
|
2_HIV - induced depletion of CD4+ T-cells
|
|
1_Microangiopathy in diabetic neuropathy
|
|
Model of PPARG signaling in psoriais (tested)
|
|
mapk1 protein modificators
|
|
Differentiation of psoriatic T cells
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|