Protein NOD2

URN urn:agi-llid:3377
Total Entities 0
Connectivity 2171
Name NOD2
Description nucleotide binding oligomerization domain containing 2
Notes This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
ObjectType Protein

Pathway NOD-like Receptors
Crohn's Disease
Paneth-Cell Function in Crohn's Disease
Macrophage Dysfunction
Proteins Involved in Inflammatory Bowel Diseases
Genes with Susceptibility for Crohn's Disease and Ulcerative Colitis
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Proteins Involved in Psoriatic Arthritis
Proteins Involved in Periodontitis
Blau Syndrome
Proteins Involved in Chronic Obstructive Pulmonary Disease
TLR1 -> 2/6 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
Overview. Diseases of the digestive system (chapter 10)
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Autophagy dysfunction in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D

Group Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Crohn's Disease
Genes with Mutations Associated with Psoriatic Arthritis

MedScan ID 3377

LocusLink ID 3377
64127
257632
291912

Alias NOD2 signaling adaptor protein
D230007K08
inflammatory bowel disease protein I
caspase recruitment domain family, member 15
PSORAS1
inflammatory bowel disease 1 locus
nucleotide-binding oligomerization domain 2
caspase recruitment domain-containing protein 15
F830032C23Rik
caspase recruitment domains 15
NOD2
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
CLR16.3
YAOS
NLR family, CARD domain containing 2
nucleotide-binding oligomerization domain II
inflammatory bowel disease 1
RIKEN cDNA F830032C23 gene
OTTHUMP00000164224
Caspase-Activation Recruitment Domain 15
nucleotide-binding oligomerization domain containing 2
inflammatory bowel disease locus 1
PSORAS I
inflammatory bowel disease protein 1
OTTMUSP00000038424
Nlrc2
IBD I
inflammatory bowel disease protein-1
F830032C23
IBD1
IBD1 locus
NOD-like receptor C2
Psoriatic arthritis, susceptibility to, 1
CARD15
Psoriatic arthritis, susceptibility to, I
BLAU
Caspase-Activation Recruitment Domain containing protein 15
Arthrocutaneouveal granulomatosis (Blau syndrome) gene
Inflammatory bowel disease-1 (Crohn disease) locus
nucleotide oligomerization domain protein 2
nod2b
CD
ACUG
BLAUS
caspase recruitment domain protein 15
nucleotide-binding oligomerization domain-containing protein 2
D230007K08Rik
Card15_predicted

GO ID 0005524
0050700
0030544
0051879
0003779
0019899
0032500
0042834
0019901
0044877
0007254
0000187
0071222
0071225
0071407
0071224
0002367
0002374
0006952
0042742
0016045
0009595
0032498
0045087
0070498
0035556
0030277
2000110
0070431
0070423
0050871
0070374
0043123
0046330
0043406
0051092
1901224
0045747
1900017
0002606
0002732
0050679
0046645
0032731
0050718
0032733
0032740
0032755
0032757
0051770
0051353
0043552
2000363
0060585
1902523
0032874
0045944
0032760
0002830
0051259
0050727
0032495
0007584
0005794
0016323
0009986
0005737
0005856
0005829
0005739
0005886
0032991
0031982
0016888
0000166
0002253
0050830
0002376
0002381
0006954
0002227
0071608
0032088
0002710
0044130
0002862
0032689
0032695
0032701
0032703
0034136
0032720
0043410
0006963
0006965
0008284
0002925
0045089
0032735
0071639
0050731
0050766
0031398
1904417
0042981
0090022
0043330
0032496
0032494
0007165
0016020
0035419
0008180
0043234
0002755
0002756
0035666
0035872
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0005622
0008063
0034130
0002282
0052033
0008152
0042995

KEGG ID hsa:64127
mmu:257632
rno:291912

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 8

OMIM ID 605956
186580
266600
607507
617321
609464

Rat chromosome position 19p11

Hugo ID 5331
HGNC:5331

Human chromosome position 16q12.1
16q21

Swiss-Prot Accession Q9HC29
A0A286YF65
Q9HC29.1
Q80SY9
Q8K3Z0.1
D4A5W3
E2JEQ6
Q96RH5
Q96RH6
Q96RH8
Q8K3Z0
Q6TDC3
Q7Z595
Q7Z596
Q7Z597
Q2PZA2
Q2PZA3
Q3V2V4
Q3V2V8
Q80SS7
Q80SV8
Q80SY7
Q80SY8
Q80SZ8
Q80UH1
Q80UH3
Q80UH4
Q80UH5
Q80UH6
Q80UH7

GenBank ID NC_000016
NR_163434
XR_933387
XR_429725
XR_429726
XM_017023536
XP_016879025
XM_017023537
XP_016879026
NM_001370466
NP_001357395
XM_006721242
XP_006721305
XM_011523260
XP_011521562
XM_006721243
XP_006721306
XM_011523261
XP_011521563
NM_022162
NP_071445
NM_001293557
NP_001280486
XM_011523259
XP_011521561
XM_017023538
XP_016879027
XM_017023535
XP_016879024
NG_007508
AB542700
BAJ13469
AB542701
BAJ13470
AC007608
AC007728
AF385085
AAK70863
AF385086
AAK70864
AF385087
AAK70865
AF385088
AAK70866
AF385089
AAK70867
AF385090
AAK70868
AF538972
AJ303140
CAC42117
AX259774
CAD10212
AX259776
CAD10248
CH471092
EAW82767
DQ869189
ABI96990
EF364441
ABN42698
EF624392
ABS17610
EF624393
ABS17611
EF624394
ABS17612
EU817180
ACF33179
EU888272
ACF95817
EU888273
ACF95818
EU888274
ACF95819
EU888275
ACF95820
FJ755457
ACX94233
FN651786
CBJ18719
FN651787
FN651788
MG581415
AYE92798
AF178930
AAG33677
AK298099
BAG60384
AY187233
AY187234
AY187235
AY187236
AY187237
AY187238
AY187239
AY187240
AY187241
AY187242
AY187243
AY187244
AY187245
AY187246
AY423901
AAQ93806
DQ868973
ABJ16061
HQ204571
ADN95581
HY272594
Q9HC29
NC_000074
XM_011248390
XP_011246692
XM_006531029
XP_006531092
NM_145857
NP_665856
XM_006531028
XP_006531091
AC156937
AH012056
AAN52480
AH012057
AAN52481
AH012058
AAN52482
AH012059
AAN52483
AH012060
AAN52484
AH012062
AAN52934
AH012063
AAN52935
AH012064
AAN52936
AH012065
AAN52937
AH012067
AAN52939
AH012069
AAN57787
AH012070
AAN57788
AH012071
AAN57789
AH012072
AAN57790
AH012073
AAN57791
AH012074
AAN57792
AH012075
AAN57793
AH012076
AAN59991
AH012077
AAN59992
AH012078
AAN59993
AH012079
AAN59994
AH012080
AAN59995
AH012104
AAN60733
AH012105
AAN60734
AH012106
AAN60735
AH012107
AAN60736
AH012108
AAN60737
AH012111
AAN62467
AH012112
AAN62468
AH012113
AAN62469
AH012114
AAN62470
AH012115
AAN62471
AH012116
AAN62472
AH012151
AAN63034
AH012152
AAN63035
AH012153
AAN63036
AH012154
AAN63037
AH012155
AAN63038
AH012156
AAN63039
AH012157
AAN63040
AH012158
AAN63041
AH012198
AAN78329
AH012199
AAN78330
AH012203
AAN84594
CAAA01040580
CH466525
EDL11059
AF520774
AAM76073
AK089390
BAE43397
AK089843
BAE43401
AY160220
AAN52477
AY160221
AAN52478
BC044774
AAH44774
DQ289012
ABC25455
DQ289013
ABC25456
Q8K3Z0
NC_005118
NM_001106172
NP_001099642
XM_017601207
XP_017456696
XM_008772372
XP_008770594
XM_008772371
XP_008770593
XM_008772373
XP_008770595
AC_000087
AABR07043076
AAHX01097535
AAHX01097536
AAHX01097537
AAHX01097538
AAHX01097539
AAHX01097540
CH474037
EDL87529
XM_005256084
XP_005256141
XM_011523258
XP_011521560
XM_011523257
XP_011521559
NC_018927
AMYH02032016
HG508052
BC152737
AAI52738
BC156571
AAI56572
AC_000030
AAHY01072987
AAHY01072988
AAHY01072989
AAHY01072990
AY160229
AY160230
AY160231
AY160232
AY160233
AY160234
AY160235
AY160236
AY160237
AY160238
AY160239
AY160240
AY160241
AY160242
AY160243
AY160244
AY160245
AY160246
AY160247
AY160248
AY160249
AY160250
AY160251
AY160252
AY160253
AY160254
AY160255
AY160256
AY160257
AY160258
AY160259
AY160260
AY160261
AY160262
AY160263
AY160264
AY160265
AY160266
AY160267
AY160268
AY160269
AY160270
AY160271
AY160272
AY160273
AY160274
AY160275
AY160276
AY160277
AY160278
AY160279
AY160280
AY160281
AY160282
AY160283
AY160284
AY160285
AY160286
AY160287
AY160288
AY160289
AY160290
AY160291
AY160292
AY160293
AY160294
AY160295
AY160296
AY160297
AY160298
AY160299
AY160300
AY160301
AY160302
AY160303
AY160304
AY160305
AY160306
AY160307
AY160308
AY160309
AY160310
AY160311
AY160312
AY160313
AY160314
AY160315
AY160316
AY160317
AY160318
AY160329
AY160330
AY160331
AY160332
AY160333
AY160334
AY160335
AY160336
AY160337
AY160338
AY160339
AY160340
AY160341
AY160342
AY160343
AY160344
AY160345
AY160346
AY160347
AY160348
AY160349
AY160350
AY160351
AY160352
AY160353
AY160354
AY160355
AY160356
AY160357
AY160358
AY160359
AY160360
AY160361
AY160362
AY160363
AY160364
AY160365
AY160366
AY160367
AY160368
AY160369
AY160370
AY160371
AY160372
AY160373
AY160374
AY160375
AY160376
AY160377
AY160378
AY160379
AY160380
AY160381
AY160382
AY160383
AY160384
AY160385
AY160386
AY160387
AY160388
AY160389
AY160390
AY160391
AY160392
AY160393
AY160394
AY160395
AY160396
AY160397
AY160398
AY160399
AY160400
AY160401
AY160402
AY160403
AY160404
AY160405
AY160406
AY160407
AY160408
AY160409
AY160410
AY160411
AY160412
AY160413
AY160414
AY160415
AY160416
AY160417
AY160418
AY160419
AY160420
AY160421
AY160422
AY160423
AY160424
AY160425
AY160426
AY160427
AY160428
AY160429
AY160430
AY160431
AY160432
AY160433
AY160434
AY160435
AY160436
AY160437
AY160438
AY160439
AY160440
AY160441
AY160442
AY160443
AY160444
AY160445
AY160446
AY160447
AY160448
AY160449
AY160450
AY160451
AY160452
AY160453
AY160454
AY160455
AY160456
AY160457
AY160458
AY160459
AY160460
AY160461
AY160462
AY160463
AY160464
AY160465
AY160466
AY160467
AY160468
AY160469
AY160470
AY160471
AY160472
AY160473
AY160474
AY160475
AY160476
AY160477
AY160478
AY160479
AY160480
AY160481
AY160482
AY160483
AY160484
AY160485
AY160486
AY160487
AY160488
AY160489
AY160490
AY160491
AY160492
AY160493
AY160494
AY160495
AY160496
AY160497
AY160498
AY160499
AY160500
AY160501
AY160502
AY160503
AY160504
AY160505
AY160506
AY160507
AY160508
AY160509
AY160510
AY160511
AY160512
AY160513
AY160514
AY160515
AY160516
AY160517
AY160518
AY160519
AY160520
AY160521
AY160522
AY160523
AY160524
AY160525
AY160526
AY160527
AY160528
AY160529
AY160530
AY160531
AY160532
AY160533
AY160534
AY160535
AY160536
AY160537
AY160538
AY160539
AY160540
AY160541
AY160542
AY160543
AY160544
AY160545
AY160546
AY160547
AY160548
AY160549
AY160550
AY160551
AY160552
AY160553
AY160554
AY160555
AY160556
AY160557
AY160558
AY160559
AY160560
AY160561
AY160562
AY160563
AY160564
AY160565
AY160566
AY160567
AY160568
AY160569
AY160570
AY160571
AY160572
AY160573
AY160574
AY160575
AY160576
AY160577
AY160578
AY160579
AY160580
AY160581
AY160582
AY160583
AY160584
AY160585
AY160586
AY160587
AY160588
AY160589
AY160590
AY160591
AY160592
AY160593
AY160594
AY160595
AY160596
AY160597
AY160598
AY160599
AY160600
AY160601
AY160602
AY160603
AY160604
AY160605
AY160606
AY160607
AY160608
AY160609
AY160610
AY160611
AY160612
AY160613
AY160614
AY160615
AY160616
AY160617
AY160618
AY160619
AY160620
AY160621
AY160622
AY160623
AY160624
AY160625
AY160626
AY160627
AY160628
AY160629
AY160630
AY160631
AY160632
AY160633
AY160634
AY160635
AY160636
AY160637
AY160638
AY160639
AY160640
AY160641
AY160642
AY160643
AY160644
AY160645
AY160646
AY160647
AY160648
AY160649
AY160650
AY160651
AY160652
AY160653
AY160654
AY160655
AY160656
AY160657
AY160658
AY160659
AY160660
AY160661
AY160662
AY160663
AY160664
AY160665
AY160666
AY160667
AY160668
AY160669
AY160670
AY160671
AY160672
AY160673
AY160674
AY160675
AY160676
AY160677
AY160678
BC168407
AAI68407
XM_008772370
XP_008770592
AC_000148
ABBA01000867
XM_006531027
XP_006531090
NT_010498
NW_926462
NW_001838288
AC_000059
Q6TDC3
Q7Z595
Q7Z596
Q7Z597
NT_078575
NW_001030904
Q2PZA2
Q2PZA3
Q3V2V4
Q3V2V8
Q80SS7
Q80SV8
Q80SY7
Q80SY8
Q80SY9
Q80SZ8
Q80UH1
Q80UH3
Q80UH4
Q80UH5
Q80UH6
Q80UH7
NW_047534
NW_001084743

Swiss-Prot ID NOD2_HUMAN
Q80SY9_MOUSE
D4A5W3_RAT

Cell Localization Cytoplasm
Membrane
Mitochondrion
Basolateral cell membrane

Ensembl ID ENSG00000167207
ENSP00000300589.2
ENST00000300589.6
ENSP00000496533.1
ENST00000646677.1
ENSP00000493088.1
ENST00000641284.1
ENSMUSG00000055994
ENSMUSP00000113773.1
ENSMUST00000118370.7
ENSRNOG00000014124
ENSRNOP00000061463.1
ENSRNOT00000065103.2
ENSP00000300589
ENST00000300589
ENSMUSP00000113773
ENSMUST00000118370
ENSRNOP00000061463
ENSRNOT00000065103

MGI ID MGI:2429397
2429397

RGD ID 1306368

Unigene ID Hs.592072
Mm.222633
Rn.218600

Homologene ID 11156

IPI ID IPI00005559
IPI00759531
IPI00886252
IPI00948526
IPI00230403
IPI00223373
IPI00720136
IPI00359351