Protein IRAK1

URN urn:agi-llid:3654
Total Entities 0
Connectivity 2116
Name IRAK1
Description interleukin-1 receptor-associated kinase 1
Notes This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Osteoarthritis
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Toll-like Receptors Act through MYD88-TIRAP Signaling
Antiviral Signaling through Pattern Recognition Receptors
Toll-like Receptors Act through MYD88 Signaling
TLR4 Signaling in Leukocytes
Th1-Cell Differentiation
Th17-Cell Differentiation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
MC1R in anti-Inflammatory Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
IL1B Expression Targets -> Nociception
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Myocardial Infarction
Lymphocyte Mediated Myocardial Injury in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Insulin Resistance in Myocytes Induced by Obesity
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
Celiac Disease
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Proteins Involved in Hodgkin Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Splenic Marginal Zone Lymphoma
Antiphospholipid Antibodies and Endothelial Cell Interaction
IL33 Signaling Related Eosinophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Th17-Cell Numbers Reduction in HIV
Toll-like Receptors (TLR) in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Microglia Activation in Alzheimer's Disease
HMGB1 and IL1B in Neuroinflammation
Microglia Activation in Parkinson's Disease
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
IDO1 in Cancer Immune Escape
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
NF-kB Canonical Signaling
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR4 -> IRF Signaling
TLR4/5/7/9 -> NF-kB Signaling
TLR1/2/6 -> NF-kB Signaling
TLR -> AP-1 Signaling
pathway 4
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
New Pathway (3)
dsRNA induces innate immunity and INFs in alveolar cells
Innate immunity in Leukocytes
AGER feed forward loop in innate immunity
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
4_3_Insulin resistance: FFA-related insulin resistance
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell

MedScan ID 3654

LocusLink ID 3654
16179
363520
102844

Alias interleukin-1 receptor-associated kinase-1b
interleukin IL1 receptor ssociated kinase I
IRAK
interleukin-1 receptor-associated kinase I
IL-1 receptor-associated kinase (IRAK) 1
IL1rak
mPLK
Pelle (Drosophila) homolog
Irak1
interleukin IL1rak
PELLE-like
OTTHUMP00000026020
IL1 receptor associated kinase I
pelle
interleukin-1 receptor-associated kinase (IRAK) 1
IL1R-associated kinase (IRAK) 1
interleukin IL1 receptor ssociated kinase 1
IL1R associated kinase 1
Plpk
IRAK1b
RGD1563841
pelle-like protein kinase
IL1R associated kinase I
Pelle homolog
IL1 receptor associated kinase 1
OTTMUSP00000020306
IRAK1-S
RP23-252M19.7
OTTMUSP00000020303
OTTMUSP00000019684
OTTHUMP00000026014
IRAK I
AA408924
interleukin-1 receptor-associated kinase 1
IRAK-1
IL1 receptor ssociated kinase 1
interleukin-1 receptor-associated kinase
interleukin-1 receptor-associated kinase-1
IL1 receptor ssociated kinase I
Irak1_predicted
Pelle homolog

EC Number 2.7.11.1
2.7.1.-

GO ID 0005524
0004704
0031072
0016301
0046982
0042803
0004672
0004674
0007254
0002755
0000187
0007250
0007568
0034605
0071456
0071222
0019221
0045087
0070498
0035556
0031663
0032088
0043066
0070423
0043123
0043406
0051092
1901224
1904996
0048661
0045893
0032481
0046777
0051259
0006468
0001959
0070555
0032496
0007165
0034134
0034142
0034162
0002224
0007178
0060337
0016032
0005737
0005829
0010008
0045323
0005811
0005634
0005886
0005149
0000166
0016740
0002376
0090370
0045892
0016310
0043507
0032494
0016020
0005622
0034146
0006916
0035872
0051403
0002756
0005515
0016567
0034138
0035666
0008063
0034130
0048011
0034166
0038123
0045944
0016772
0038124
0004842
0016563
0032582
0005624
0004872
0008152
0005625
0045941
0000287
0007249
0010874
0002237
0019901

KEGG ID hsa:3654
mmu:16179
rno:363520

MedLine Reference 10191251
10383454
10395652
10395695
10723722
10854325
10899313
11076863
11096118
11287640
11397809
11518704
11701612
11744690
11777917
11828002
11937546
11953430
11960013
11976320
12034707
12055225
12138165
12242293
12370331
12391239
12477932
12496252
12566447
12619925
12721283
12724322
12856330
12860405
12874243
12925853
14625308
14684752
14752294
15069085
15084582
15465816
15489334
15489336
15523691
15647277
15691841
15767370
15829295
16024789
16052631
16094384
16107720
16203735
16286016
16381901
16477006
16690127
16831874
17053167
17276401
17382928
8599092
8837778
9286695
9371760
9374458
9625770
9918122
10190904
10224059
10349636
10673339
10754329
10922068
11042159
11076861
11217851
12054681
12418963
12466851
12626533
12819136
12855817
12860565
14660668
14673102
15102471
15292196
15555532
15782199
15849359
15896328
16046709
16141072
16141073
16247769
16917541
17477969
8663605
8889548
8905588
9530638
9625767
15793310
15890643
15946255

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position X 37.61 cM
X 29.6 cM

OMIM ID 300283

Rat chromosome position Xq37
1
X

Hugo ID 6112
HGNC:6112

Human chromosome position Xq28

Swiss-Prot Accession P51617
D3YTB5
P51617.2
B1AUW6
Q8BR10
Q540G0
Q62406
Q62406.3
B2RYH5
D3DWW3
D3DWW4
Q7Z5V4
Q96C06
Q96RL2
B1AUW4
Q6Y3Z5
Q6Y3Z6
Q8K4N5
Q8K4N6
Q8K4N7
Q8K4N8
Q99J34

PIR ID G02512

GenBank ID NC_000023
XM_005274668
XP_005274725
NM_001025243
NP_001020414
NM_001025242
NP_001020413
NM_001569
NP_001560
NG_008387
AF030876
AAC08756
CH471172
EAW72760
EAW72761
EAW72762
EAW72763
EAW72764
EAW72765
HF583647
CCQ43144
KT584727
U52112
AF346607
AAK62888
BC014963
AAH14963
BC054000
AAH54000
BE276817
DQ054788
AAY88246
L76191
AAC41949
P51617
NC_000086
NM_001177976
NP_001171447
NM_001177974
NP_001171445
NM_001177973
NP_001171444
NM_001177975
NP_001171446
NM_008363
NP_032389
AB088390
BAC06196
BAC06197
BAC06198
AC091472
AF121351
AL672002
CH466650
EDL29846
EDL29847
EDL29848
EDL29849
EDL29850
AB088370
BAC05683
AF103876
AAD13224
AK009132
AK045958
BAC32547
AK052933
AK143694
BAE25502
AK144879
AK183779
AK196997
AK198649
AK203259
AK210148
AY184362
AAO63012
AY184363
AAO63013
AY184364
AAO63014
BC004778
AAH04778
BP760087
BY729815
U56773
AAC52694
Q62406
NC_005120
NM_001127555
NP_001121027
XM_006229598
XP_006229660
AC_000069
AAHX01006903
AC106169
CH474099
EDL84996
BC166780
AAI66780
ACE86439
EU831520
NW_003871103
CAL38089
EU831427
ABBA01045321
ABBA01045322
AC_000042
ACE87114
CAM18731
CAM18730
AAHY01212722
AC_000155
CAM18729
NC_018934
XP_005277899
CAM18740
CAM18737
CAM18736
CAM18739
CAM18738
CAM18733
CAM18732
XM_011531158
CAM18735
CAM18734
AM392624
NC_005100
XM_005277842
CAL37502
AMYH02040852
AABR06006958
XP_011529460
AM393211
NT_167198
NW_001842419
NW_927732
NG_007107
AC_000066
CR604638
CR611861
CR619624
Q96C06
NT_039706
NW_001035173
Q540G0
Q8BR10
Q8K4N5
Q8K4N6
Q8K4N7
Q8K4N8
Q99J34
NW_001084770
NW_048052
NT_011726
XM_001057078
XP_001057078
XP_343845
NT_039745
XM_343844
117645246
117646774
119593166
119593167
119593168
119593169
119593170
119593171
121945341
121947255
1220313
14485012
15929005
3002590
32450332
68235820
74751786
8928535
Q0JTS3
Q0JVF8
123122658
123122659
123122660
123122661
123122662
12409196
13435858
148697899
148697900
148697901
148697902
148697903
15214058
21907906
21952766
26337723
29119242
29119244
29119246
4235482
74150742
81866794
81866795
81866796
81866797
81872982
81874791
81903008
BE949425
BG074046
BG076768
AA408924

Swiss-Prot ID IRAK1_HUMAN
IRAK1_MOUSE
D3DWW3_HUMAN
B2RYH5_RAT
Q96C06_HUMAN
Q540G0_MOUSE
B1AUW6_MOUSE
Q8BR10_MOUSE
D3DWW4_HUMAN

Cell Localization Cytoplasm
Nucleus
Lipid droplet

Ensembl ID ENSG00000184216
ENSP00000377291.2
ENST00000393687.6
ENSP00000358991.2
ENST00000369974.6
ENSP00000358997.3
ENST00000369980.8
ENSP00000392662.2
ENST00000429936.6
ENSMUSG00000031392
ENSMUSP00000033769.8
ENSMUST00000033769.14
ENSMUSP00000064448.5
ENSMUST00000068286.11
ENSMUSP00000109994.3
ENSMUST00000114354.9
ENSMUSP00000110000.3
ENSMUST00000114360.9
ENSMUSP00000109992.1
ENSMUST00000114352.7
ENSRNOG00000060869
ENSRNOP00000070832.1
ENSRNOT00000092207.1
ENSMUSP00000033769
ENSP00000377287
ENSMUST00000114360
ENSRNOT00000065177
ENST00000393687
ENST00000393682
ENSRNOP00000061751
ENSRNOT00000092207
ENSP00000358991
ENSRNOP00000070832
ENSP00000392662
ENST00000369980.7
ENSP00000358997
ENSMUST00000033769
ENSMUSP00000064448
ENST00000429936
ENST00000369980
ENSMUST00000068286
ENSMUSP00000109994
ENSMUSP00000109992
ENSMUSP00000110000
ENST00000369974
ENSRNOG00000037263
ENSMUST00000114354
ENSMUST00000114352
ENSP00000377291

MGI ID MGI:107420
107420
2147821

RGD ID 1563841

Unigene ID Hs.522819
Rn.22238
Mm.38241

Homologene ID 37496

Shape Sickle-vertex

IPI ID IPI00293652
IPI00474424
IPI00472717
IPI00385328
IPI00125866
IPI00940703
IPI00060149
IPI00950547
IPI00114859
IPI00752328
IPI00640278
IPI00647563
IPI00646527
IPI00646038
IPI00879385
IPI00894401
IPI00652700
IPI00828277
IPI00828308
IPI00828350
IPI00890138
IPI00828379
IPI00830416
IPI00828949
IPI00828905
IPI00830776
IPI00896173
IPI00776724

Homo sapiens Chromosome position Xq28

Ensembl Transcript ID ENST00000369980
ENST00000369974
ENST00000393687

FunctionalClass ATP binding
NF-kappaB-inducing kinase
magnesium ion binding
nucleotide binding
protein binding
protein homodimerization
protein kinase binding
protein serine/threonine kinase
receptor
transcription activator
transferase
interleukin-1 receptor binding
kinase
protein kinase

Mus musculus Chromosome position X 29.6 cM
X

KEGG pathway Apoptosis
Toll-like receptor signaling pathway

Rattus norvegicus Chromosome position Xq37

Ensembl Gene ID ENSG00000184216