URN | urn:agi-llid:4973 |
---|---|
Total Entities | 0 |
Connectivity | 1631 |
Name | OLR1 |
Description | oxidized low density lipoprotein receptor 1 |
Notes | This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
Pathway | Scavenger Receptors in Platelet Aggregation |
---|---|
Proteins Involved in Atherosclerosis | |
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction | |
Proteins Involved in Diabetic Neuropathy | |
Proteins Involved in Age-Related Macular Degeneration | |
Noradrenaline/Gs Expression Targets | |
Noreadrenaline/Gq Expression Targets | |
Elevated Receptors -> Expression Targets in Aorta | |
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets | |
F2 -> STAT1/NF-kB Expression Targets | |
HBEGF -> AP-1/ATF Expression Targets | |
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer | |
IL6 Expression Targets | |
IL4 Expression Targets | |
EDN1 Expression Targets | |
AGT -> CREB Expression Targets | |
AGT -> STAT Expression Targets | |
TGFB1-TGFBR2 Expression Targets | |
TGFB1-TGFBR1/AP-1 Expression Targets | |
TGFB1-ACVRL1 Expression Targets | |
TNF -> NF-kB Expression Targets | |
TNF -> AP-1 Expression Targets | |
IL1B Expression Targets | |
TLR4 -> NF-kB/IRF Expression Targets | |
TLR9 Expression Targets | |
Model of PPARG signaling in psoriasis | |
PPARG negative regulators and targets | |
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis |
MedScan ID | 4973 |
---|
LocusLink ID | 4973 |
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108078 | |
140914 |
Alias | Lectin-like oxidized low-density lipoprotein receptor-1 |
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hLOX-1 | |
lectin-like oxidized low-density lipoprotein receptor | |
LOX-1 | |
LOX-I | |
oxidized low density lipoprotein (lectin-like) receptor 1 | |
LOXIN | |
oxidized low density lipoprotein (lectin-like) receptor I | |
SCARE1 | |
oxidized low-density lipoprotein receptor 1 | |
oxidized LDL receptor 1 | |
Oldlr1 | |
OLR1 | |
lectin-type oxidized LDL receptor I | |
scavenger receptor class E, member 1 | |
oxidized low-density lipoprotein receptor 1, soluble form | |
SLOX1 | |
scavenger receptor class E | |
Oldr1 | |
SR-EI | |
CLEC8A | |
Lectin-like OXIDIZED LDL receptors | |
lectin-like oxLDL receptor 1 | |
scavenger receptor class E, member I | |
lectin-type oxidized LDL receptor 1 | |
lectin-like oxidized LDL receptor 1 | |
C-type lectin domain family 8 member A | |
ox LDL receptor 1 | |
Lectin-like OXIDIZED LDL receptor | |
LOX1 | |
ox-LDL receptor 1 | |
oxidised low density lipoprotein (lectin-like) receptor 1 | |
oxidised low density lipoprotein (lectin-like) receptor I |
GO ID | 0030246 |
---|---|
0008015 | |
0007155 | |
0006954 | |
0050900 | |
0043312 | |
0006508 | |
0005576 | |
0005887 | |
0043231 | |
0016020 | |
0045121 | |
0005654 | |
0005886 | |
0043235 | |
0035579 | |
0070821 | |
0005041 | |
0008219 | |
0002376 | |
0007159 | |
0042157 | |
0010629 | |
0019897 | |
0016021 | |
0097756 | |
0032930 | |
0042542 | |
0016192 | |
0006898 | |
0070062 | |
0004872 | |
0007596 | |
0005634 |
KEGG ID | hsa:4973 |
---|---|
mmu:108078 | |
rno:140914 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 6 |
---|
OMIM ID | 602601 |
---|---|
608446 |
Rat chromosome position | 4q42 |
---|
Hugo ID | 8133 |
---|---|
HGNC:8133 |
Human chromosome position | 12p13.2 |
---|---|
12p13.2-p12.3 |
Swiss-Prot Accession | P78380 |
---|---|
A0A024RAU0 | |
P78380.1 | |
G4WK10 | |
G4WK09 | |
Q9EQ09 | |
Q9EQ09.2 | |
A0A0G2K1K0 | |
O70156 | |
O70156.1 | |
A8K7V9 | |
B4DI48 | |
G3V1I4 | |
Q2PP00 | |
Q7Z484 | |
Q3U3M1 |
PIR ID | JE0111 |
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Swiss-Prot ID | OLR1_HUMAN |
---|---|
OLR1_MOUSE | |
OLR1_RAT |
Cell Localization | Cell membrane |
---|---|
Membrane raft | |
Secreted |
Ensembl ID | ENSG00000173391 |
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ENSP00000405116.2 | |
ENST00000432556.6 | |
ENSP00000439251.1 | |
ENST00000545927.5 | |
ENSP00000309124.3 | |
ENST00000309539.8 | |
ENSMUSG00000030162 | |
ENSMUSP00000138588.1 | |
ENSMUST00000182784.3 | |
ENSMUSP00000138228.1 | |
ENSMUST00000183258.7 | |
ENSMUSP00000032265.6 | |
ENSMUST00000032265.12 | |
ENSRNOG00000056219 | |
ENSRNOP00000071872.1 | |
ENSRNOT00000086390.1 | |
ENSP00000405116 | |
ENST00000432556 | |
ENSP00000439251 | |
ENST00000545927 | |
ENSP00000309124 | |
ENST00000309539 | |
ENSMUSP00000138588 | |
ENSMUST00000182784 | |
ENSMUSP00000138228 | |
ENSMUST00000183258 | |
ENSMUSP00000032265 | |
ENSMUST00000032265 | |
ENSRNOP00000071872 | |
ENSRNOT00000086390 | |
ENSRNOG00000008375 | |
ENSRNOP00000011196 | |
ENSRNOT00000011196 |
MGI ID | MGI:1261434 |
---|
RGD ID | 620515 |
---|
Unigene ID | Hs.412484 |
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Mm.293626 | |
Rn.87449 |
Homologene ID | 1910 |
---|
Shape | Stick-vertex |
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