Protein MAPK3

URN urn:agi-llid:5595
Total Entities 0
Connectivity 6205
Name MAPK3
Description mitogen-activated protein kinase 3
Notes The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Osteoarthritis
Skin Aging
Melatonin Effects on Circadian Cycle
High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
Leptin and CCK8 Activate Nodose Ganglia Neuron
Insulin Influence on Protein Synthesis
Insulin Synthesis in beta-Cell
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Norepinephrine Release Regulation
CRH Secretion Regulation
Insulin Signaling
Prolactin Production
Thrombopoietin Receptors Signaling in Platelet Maturation
Mineralcorticoids Secretion Regulation
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
V(D)J Recombination Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
MC1R in anti-Inflammatory Signaling
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Nociception Expression Targets Signaling
Vascular Motility
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA2C/ADRB2 -> Vasoconstriction
ADRB1 -> Prostaglandin Generation
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD1/5 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR7 -> IL6 Production
HTR5 -> TNF Production
IL1B Expression Targets -> Nociception
CHRNA7 -> NOS1 Production
GABA(B)R -> Postsynaptic Inhibition
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
P2RY11/13/14 -> IL8/10 Production
Luteinizing Hormone in Oocyte Meiotic Resumption
Melatonin in Cell Survival and Antioxidant Response
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
Cell Cycle Overiew
Gap Junction Assembly
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Th1-Cells Activation and Proliferation in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Endothelial Cell Dysfunction in Arterial Hypertension
Aldosterone Synthesis Chronic Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Endothelial Cell Dysfunction in Pulmonary Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
BMP2 and Canonical WNT Signaling in Pulmonary Artery Endothelial Cells
Myocardial Remodeling
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Contraction Due Vasospasm
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Proteins with Altered Expression in Melanoma
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
AGE Related Insulin Resistance in Skeletal Muscles
Adiponectin Synthesis Declines in Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hyperparathyroidism, Neonatal Severe
RET1 Mutation in Hyperparathyroidism
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Myocyte Dysfunction in Hypoparathyroidism
Hypoparathyroidism, Primary
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Proteins Involved in Obesity
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Metastatic Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Follicular Lymphoma
Hodgkin Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TRPM7/8 in Pancreatic Adenocarcinoma
TGFBR Signaling in Pancreatic Neoplasms
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
Eosinophil Activation and Degranulation in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Neutrophil Degranulation via FPR1/IL8
Antigen-Presenting Cell Role in Asthma
Th2-Cell Response in Asthma
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Ovulation Block
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
WHIM Syndrome
Dentin Formation Disruption
CCR5 Signaling in Macrophages
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Cowden Syndrome
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Synaptic Exocytosis in Dementia
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Glioma
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Proteins Involved in Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
MIF Role in Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Fatty Acid Synthase (FASN) Signaling
Androgen Receptor/FKBP5 Signaling
Prostate Cancer
TRPM8 Effects in Prostate Cancer (Hypothesis)
Proteins Involved in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Proteins Involved in Glaucoma
PGF2-alpha Effect on Treatment
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Alveolar Macrophage Negative Regulation Declined in COPD
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
Alveolar Epithelial Cell Dysfunction in COPD
Polycystins Mutation Effects in Cystic Kidney Disease
Proteins Involved in Erectile Dysfunction
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Sertoli Cells Dysfunction Causes Male Infertility
Proteins Involved in Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
GLP1R -> ARRB1 Signaling
IGF1R -> ARRB1/ERK1/3 Signaling
AGTR1 -> ARRB1/ARRB2 Signaling
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CHRNA7 -> CREB Signaling
Clozapine Induced Granulocytopenia
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
GCG Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
MTOR/TORC in Cancer Cell Motility and Invasion
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Lactate as a Signaling Molecule in Cancer Cells
Treg Cells Promote Immunosuppression in Cancer Immune Escape
HCAR1/HCAR2 -> MAPK Signaling
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
AGER -> CREB/SP1 Signaling
NCAM1 -> CREB/ELK/SRF/MYC Signaling
CD19 -> JUN/ELK Signaling
PECAM -> SP1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
InsulinR -> ELK/SRF/SREBF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
IL6R -> CEBP/ELK/SRF Signaling
IL2R -> ELK/SRF/MYC Signaling
IL1R -> NF-kB Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL16 -> AP-1 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
S1P Expression Targets
PGE1 Expression Targets
MTNR1 Signaling
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
Adenosine Expression Targets
OR1A1 -> GNAS Signaling
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
MERTK Signaling
TGF-beta Signaling
AXL Receptor Tyrosine Kinase Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
ERK/MAPK Canonical Signaling
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
TGFA -> TP53 Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pathway 3
ace2
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of tumor size
Neighbors of infarct size
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of bone mass
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of bone mineral density
Neighbors of radioresistance
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of viral load
Neighbors of systolic blood pressure
Neighbors of blood glucose
Neighbors of energy expenditure
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of cell permeability
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of lymphocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of tumor size
Neighbors of infarct size
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of macrophage count
Neighbors of bone mass
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of bone mineral density
Neighbors of radioresistance
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of viral load
Neighbors of systolic blood pressure
Neighbors of blood glucose
Neighbors of energy expenditure
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of cell permeability
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of lymphocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of cell development
Neighbors of immune response
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of ossification
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of hepatocyte proliferation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of neuroinflammation
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of ischemic stroke
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of melanoma
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of proteinuria
Neighbors of monocyte
Neighbors of macrophage
Neighbors of pneumocyte
Neighbors of endothelial cell
Neighbors of granulocyte
Neighbors of stem cell
Neighbors of chondrocyte
Neighbors of heart
Neighbors of cerebral cortex
Neighbors of nervous system
Neighbors of trachea
Neighbors of PKC
Neighbors of mitogen-activated protein kinase
Neighbors of interferon
Neighbors of PDGF-BB
Neighbors of heat shock protein 90
Neighbors of vitronectin receptor (integrin)
sars-cov no binding
1_Inflammation in keratinocytes in the pathology of acne
2_Hyperseborrhea in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Osteoblast-mediated bone demineralization
1_Formation of cysts in polycystic kidney disease
3_The role of interstitial fibroblasts in pyelonephritis
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_CD8+ T-cell response and mucosal damage in celiac disease
1_1_Insulin synthesis and secretion: insulin processing and storage
4_1_Insulin resistance: insulin signaling
3_Islet beta-cell destruction in T1D
1_Microangiopathy in diabetic neuropathy
2_1_General pathways of thyroid hormone signaling
public list
New Pathway
HRAS->RAF->MAPK1/3
KRAS->RAFs->MAPK1/3
NRAS->RAFs->MAPK1/3
Other RASs-RAFs-MAPK1/3
mapk1
New Pathway
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Cowden Syndrome
other partners for SARS

Source GO component
ResNet
curated

MedScan ID 5595

LocusLink ID 5595
26417
50689
327402
531391
19095
399480
557882
326417
107837
17757

Alias mitogen activated protein kinase ERK 1
OTTMUSP00000017737
OTTHUMP00000174541
ERK1 protein kinase
OTTMUSP00000017736
OTTHUMP00000174538
p44 MAP kinase
mitogen-activated 3
protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1)
Esrk1
ERT2
Extracellular signal-regulated kinase 1
MAPK p44
MAP kinase ERK1
protein kinase, mitogen-activated III
extracellular signal-related kinase 1c
rMNK1
ERK1
p44erk1
Insulin-stimulated MAP2 kinase
pp42/MAP kinase
ERK1 MAP kinase
OTTHUMP00000174540
MAP kinase III
HUMKER1A
Mtap2k
HS44KDAP
Extracellular signal-regulated kinase I
PRKM3
p44/42 mapk
mitogen activated protein kinase p44
mitogen-activated 3 (MAP kinase 3
mitogen activated kinase 3
extracellular signal-related kinase 1
mitogen-activated III
MGC20180
MAP kinase isoform p44
mitogen activated protein kinase III
p44 ERK
Microtubule-associated protein-2 kinase
MAP kinase 3
Esrk I
extracellular signal-regulated kinase (ERK) 1
MAPK3
protein kinase, mitogen-activated 3 (MAP kinase 3, p44)
mitogen-activated 3 (map kinase 3; p44)
p44 mitogen activated protein kinase
extracellular signaling-regulated kinase 1
protein kinase, mitogen-activated 3
OTTMUSP00000017735
p44erk I
ERK I
protein kinase ERK1
p44mapk
ERK-1
p44-ERK1
p44-MAPK
MAPK 1
microtubule-associated protein 2 kinase
mitogen-activated protein kinase 3
p44
Mnk1
MAPK1
MAP kinase 1
MAPK 3
mitogen-activated protein kinase 1
p44)
mitogen activated protein kinase 3
protein kinase, mitogen activated kinase 3
extracellular-signal-regulated kinase 1
Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1)
protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)
LOC557882
similar to glycogen synthase kinase 3
scaffold
wu:fi06b09
chromosome
Serum phospholipid level QTL 1
similar to extracellular signal-regulated kinase I
similar to microtubule-associated protein-2 kinase
similar to extracellular signal-regulated kinase 1
fi06b09
Lil2
Serum phospholipid level QTL I
Lipid Level QTL 2
Lipid Level QTL II
protein kinase
kinase, mitogen-activated 3 (MAP kinase 3; p44)
Scl23
protein kinase, mitogen-activated 3 (MAP kinase 3; p44)
similar to extracellular signal-related kinase 1c

EC Number 2.7.11.24
2.7.11.1
2.7.1.37
2.7.1.-

GO ID 0005524
0004707
0004708
0019902
0001784
0097110
0030509
0060020
0006975
0070371
0038095
0038096
0000165
0000187
0000186
0007568
0006915
0019369
0007411
0061308
0051216
0072584
0007049
0034198
0071276
1903351
0071260
0071310
0034614
0071356
0046697
0060324
0008543
0070498
0035556
0031663
0060425
2000657
0042473
0018105
0038083
0016310
0030168
0070374
0031281
0002741
0010628
0035066
0033129
0010759
1905050
0001934
0051973
1904355
0032212
0045944
0045727
1904417
0006468
0065003
0051090
0090170
0030641
1900034
0051493
2000641
0010468
0030278
0014066
0032872
0070849
0043330
0009636
0019233
0051403
0048538
0030878
0060440
0006361
0016032
0005794
0005901
0005737
0005856
0005829
0005769
0005925
0005770
0005739
0005635
0005654
0005634
0005886
0032991
0031143
0016301
0000166
0004672
0004674
0016740
0009887
0006974
0014032
0032496
0007165
0006351
0016020
0060397
0000189
0006461
0070062
0015630
0043234
0045893
0002755
0002756
0007265
0035666
0007596
0034605
0019221
0007173
0010467
0045087
0008286
0048011
0007264
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0006360
0048010
0016772
0019048
0005730
0008063
0034130
0008152
0023014
0005622
0007243
0044419
0030528
0005626
0005625
0023034
0045941
0005515
0005575
0003700
0007242
0004682
0008372
0004713
0004691
0000074

KEGG ID hsa:5595
mmu:26417
rno:50689

MedLine Reference 12783880
17161379
15314156
16616413
12270934
16368546
17581212
15247297
15778391
17164422
12218048
17615382
12218045
12971962
10780709
8424957
16871540
11994544
12408764
12200131
9325171
15671028
16343798
8806671
11579140
16873684
1889806
12805214
12792650
12466851
12697810
12130649
12637525
12730054
14769808
1347949
15890751
15170225
16510265
11217851
8632909
9792677
12540563
15721302
16950125
15210734
12562867
1922387
12947325
15721216
16492667
17005865
14966273
10570282
17464174
17427197
12349907
17131384
11134045
11994045
11884401
11844932
15917991
16944316
17297454
10648599
15262203
15582777
15923189
12629153
15574735
16943367
17337702
14675480
16916926
15243131
15880942
14622970
15502830
12082091
17464186
15985432
9628824
16954218
17548467
16321971
12935895
14568551
12538595
15256218
11805112
16317051
12727216
15829913
15964695
16047735
15899793
16278291
17458890
15347670
15078890
1319925
15489642
14671106
15899886
14714552
12393899
16278684
16272159
17317670
16291755
17522155
16621802
14636584
14522949
14988413
16906226
15937334
16538383
11841548
17142261
11961297
17237147
9421269
12469121
1712480
15249224
16373414
11307167
7592886
11042159
17267664
11952164
16141211
16116448
14688221
11409852
16979915
16139272
12081562
10574913
15691764
15118098
16280323
17574041
15572359
15739119
16149052
14576154
16617096
15071597
17363453
11356865
15616583
9621077
17333127
12050114
15040022
17149612
15991247
12773577
14605008
8444355
16888810
17015703
11937531
17309799
15371543
15967991
12072567
14702039
16805921
8208531
17410437
8152805
11832339
12800247
16887830
17582742
17512932
16857343
16978658
7619503
15229233
12584202
12832284
16514068
16287813
10051434
16990258
14670631
8794306
15364926
11131153
8626571
15327774
16432225
9060415
1846291
16941494
16705745
12606501
17074386
12134156
16714296
16837555
17256754
12477973
15030409
15321994
15030407
12603851
16794828
17107998
12661038
10206983
12637339
15731359
16081426
12623863
16914058
16730415
11702783
12718435
12551961
11583024
12482669
14587029
16887817
15563472
17274723
15489334
17212589
12538349
17513610
15247230
12393886
8290275
16814421
15030400
12388422
12388423
11260070
17088403
16510590
17417601
15128760
15811423
16687572
17490811
15737734
16049186
10559944
12700162
16707097
12529294
11889128
16239230
12705474
12555071
16106045
16795048
17113581
9792705
16399079
7592946
15273746
10912793
12535947
12854829
10551817
16611738
17068135
17077290
12456688
10748187
17396120
12960100
12736212
17382881
17068339
17507094
17371162
12943720
14597424
16670284
11726647
16808899
14960303
14963006
17442737
12223545
16867183
17107949
1716439
15305288
14651992
17311928
14673008
12095152
17215072
7535768
12032872
11682603
12161450
17068343
12612072
11923482
8108135
11891214
15686869
15975997
7797459
15655348
12477932
10349636
16944453
12081892
11923207
16467359
16966488
12925581
12699904
11923300
16926156
17522999
15355986
16670094
11866540
17396111
11866440
12821662
9371744
14501944
16242072
15051723
17442811
12042309
14605001
11278799
17418417
8939914
17543571
17504381
16226508
12446729
12937136
17499702
15975921
11830463
15901735
14575703
1540184
17583675
15059773
12832467
17341442
12473660
9779826
17709754
7997269
15617763
17496918
15383658
16844778
12097372
17016429
15748847
11741977
16020276
8626767
17443665
15125795
7687743
16641227
15121188
16624816
15922485
15113754
11076861
10635328
17314319
11799072
17303384
10224087
15026121
8552640
17303382
9149902
11773377
9558095
16863646
12663502
12930843
16893669
16081808
15757891
17525735
15784503
15746430
14566055
15336571
12072413
14602725
15282307
12097495
15797923
15069082
15107845
12920127
17351113
15365619
15016620
15537893
12689928
9415407
15068691
12183542
16644735
17192257
16998804
17081988
15257182
16641100
15020650
14502223
17081983
15166036
17628608
16283431
17294242
15544353
16344560
1717989
15052686
17478078
15471881
12872135
17149706
15537896
11668049
17237423
16319118
14593093
15132979
14634061
16737746
16820791
12362243
10982368
16207820
14552884
16326014
11789669
14715940
15545519
16820883
16735500
17035635
15498890
14634064
12388473
15695173
15072963
7836374
17239373
15728253
16595703
16515552
10922068
16126730
17583725
17695723
1437147
15951569
14711824
15677498
16614081
14532121
16973750
12167619
12223406
12794156
16414009
14580718
12955074
12441075
11986622
16897752
15537391
11930938
12531514
11044099
14749824
12782152
11741541
15203192
14741046
12435482
16126724
15921682
12132588
17482686
16135819
12217325
16849642
12491158
16156742
9087672
12647296
16556602
16217033
12871576
16407894
8226933
10074203
11756405
12121979
9223324
7939721
12663469
16504549
15573401
12213812
16368932
15158083
11687663
12849998
9733512
16050810
16972271
12643788
12663671
17560563
11792123
17265428
16831126
11160759
15650391
16627622
17502994
15456767
14984009
15879168
15242988
16820947
17183546
15201339
16332685
17662006
9857190
14515181
15569628
16574793
16569214
11776327
1327976
16699726
15735702
15143154
14597699
15642734
15907834
9535927
12880367
16533948
15542825
12006386
15292176
15322023
10558995
14701865
16044092
14701866
15143165
14718391
12062026
16782007
15297310
10958792
15964803
10627507
10825211
12952860
16406609
15509801
16141073
16141072
15169786
12057008
14676217
16995340
17065231
16796978
17510316
11960991
15653554
12030372
12645629
14638694
9155018
11409918
16813525
11684667
16934944
14506249
17209045
16024175
12676937
15064239
16004581
16482086
16554472
16273281
17308007
17198696
10799874
16723512
16723511
15950773
15809051
2164259
8896447
15814736
12068299
70317
17600551
17273789
14744867
16040801
17029782
12810719
17620366
15173068
17072965
16253958
16209712
10509564
15322069
15572037
10402467
15629424
12921749
14985328
16691571
8639570
12810726
16434965
17641779
16039615
11875120
17022980
15964902
12682854
12690112
11756441
16877348
11114188
15919053
15249196
17388789

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Bos taurus

Mouse chromosome position 7 69.25 cM
7 61.0 cM

OMIM ID 601795
61408
OMIM:601795

Rat chromosome position 1q36

Hugo ID 6877
HGNC:6877

Human chromosome position 16p11.2

Swiss-Prot Accession P27361
Q9BWJ1
L7RXH5
P27361.4
Q63844
Q63844.5
P21708
P21708.5
A8CZ58
B0LPG3
Q8NHX1
Q61531
Q8K0X5
Q91YW5
Q4PIY8
Q62686
Q9JJ13
Q7Z3H5
Q8NHX0
Q3U2H3
Q8NHX1_HUMAN
MK03_RAT
A8CZ58_HUMAN
B0LPG3_HUMAN
MK03_HUMAN
MK03_MOUSE

PIR ID A48082
S28184
JC1451

GenBank ID NC_000016
XR_243293
NM_001109891
NP_001103361
NM_002746
NP_002737
NM_001040056
NP_001035145
NG_029936
AC012645
AC243947
AJ222708
CH471238
EAW79912
EAW79913
EAW79914
EAW79915
EAW79916
EAW79917
EU332853
ABY87542
HC462820
CBK51145
JX512450
AGC09597
AK091009
BAG52261
AK307995
AY033607
AAK52329
AY033608
AAK52330
BC000205
AAH00205
BC013992
AAH13992
BX537897
CAD97888
DA351318
DQ399291
ABD60302
KJ534878
AHW56518
M84490
AAA36142
X60188
CAA42744
Z11696
CAA77754
P27361
NC_000073
NM_011952
NP_036082
AC124505
X90997
AK155287
BAE33167
BC013754
AAH13754
BC029712
AAH29712
BQ929318
S58470
AAB19973
X64605
CAA45889
Z14249
Q63844
NC_005100
NM_017347
NP_059043
AC_000069
AABR07005779
AAHX01008512
AF155236
AAF71666
M38194
AAA41123
M61177
AAA63486
S46779
AAA11604
U05219
U12008
AAA20009
X65198
CAA46318
P21708
NC_018927
DQ893440
ABM84366
DQ896778
ABM87777
AC_000029
AAHY01066409
AC_000148
ABBA01013103
AABR06008868
NT_010393
NW_001838235
NW_926539
AC_000059
CR595737
CR596064
CR597147
CR600245
CR603463
CR606522
CR607536
CR620058
CR621455
CR621688
CR621977
Q7Z3H5
Q8NHX0
Q8NHX1
Q9BWJ1
NT_039433
NW_001030877
Q3U2H3
NW_047562
NW_001084773
XM_001079997
XP_001079997
204052
204051
204054
204053
258470
557882
38257141
31220
31221
38257140
BI414398
124000537
12652898
12652899
20988620
21749281
AW128045
56627
547569
56626
20988619
XP_686128
123787473
NT_089315
ZDB-GENE-030131-5613
52001483
50858
50859
23882
Dr.113689
NC_007326
XM_681036
74759131
3273090
8050445
8050444
8393330
8393331
236372
20384794
20384796
236373
20384795
20384797
XM_914793
31873913
31873912
34860310
123993529
21489933
74760366
21489932
15559271
15559270
125804488
dre:557882
51480188
51472974
115311606
984670
XP_919886
Q4PIY8
186696
1335009
186695
119600318
119600319
74717576
BG075319
232066
119600322
119600323
119600320
119600321
515499
515498
AW116014
XP_609884
74199274
15489307
15489308
51762371
NC_007112
126002739
NW_001511913
XM_609884
74760367
NW_001494303
232067

Swiss-Prot ID MK03_HUMAN
MK03_MOUSE
MK03_RAT
Q8NHX1_HUMAN
A8CZ58_HUMAN
Q9BWJ1_HUMAN
B0LPG3_HUMAN

Cell Localization Cytoplasm
Nucleus
Membrane
Caveola
Plasma membrane

Ensembl ID ENSG00000102882
ENSP00000378625.3
ENST00000395199.7
ENSP00000327293.5
ENST00000322266.9
ENSP00000263025.4
ENST00000263025.9
ENSMUSG00000063065
ENSMUSP00000051619.9
ENSMUST00000057669.15
ENSRNOG00000053583
ENSRNOP00000070784.1
ENSRNOT00000087625.1
ENSP00000378625
ENST00000395199
ENSP00000327293
ENST00000322266
ENSP00000263025
ENST00000263025
ENSMUSP00000051619
ENSMUST00000057669
ENSRNOP00000070784
ENSRNOT00000087625
ENSRNOG00000019601
ENSRNOP00000026627
ENSRNOT00000026627

MGI ID MGI:1346859
1346859
105920
97176

RGD ID 3046
61408

Unigene ID Hs.861
Mm.8385
Rn.2592
Dr.113689
Bt.5687

Homologene ID 55682

Shape Sickle-vertex

IPI ID IPI00018195
IPI00206172
IPI00231081
IPI00230277
IPI00742900
IPI00304111
IPI00984821
IPI00793141
IPI00654328
IPI00750828
IPI00776948

Microarray ID 1427060_at
101834_at

Homo sapiens Chromosome position 16p11.2
16p12-p11.2

Ensembl Transcript ID ENST00000263025
ENST00000403394
ENST00000322266
ENST00000395199
ENST00000395202

ENSEMBL ENSG00000102882

FunctionalClass protein kinase
kinase
MAP kinase
protein binding
protein-tyrosine kinase
protein kinase CK2
phosphotyrosine binding
nucleotide binding
protein serine/threonine kinase
transferase
ATP binding
cAMP-dependent protein kinase

Hugo Symbol MAPK3

Bos taurus Chromosome position 25

Mus musculus Chromosome position 7 61.0 cM

KEGG pathway Chronic myeloid leukemia
Gap junction
Colorectal cancer
Melanoma
Melanogenesis
Natural killer cell mediated cytotoxicity
Focal adhesion
Long-term potentiation
Dorso-ventral axis formation
ErbB signaling pathway
Endometrial cancer
Glioma
GnRH signaling pathway
Long-term depression
Renal cell carcinoma
Non-small cell lung cancer
Axon guidance
Pancreatic cancer
MAPK signaling pathway
TGF-beta signaling pathway
mTOR signaling pathway
VEGF signaling pathway
Adherens junction
Thyroid cancer
Insulin signaling pathway
Type II diabetes mellitus
Regulation of actin cytoskeleton
Fc epsilon RI signaling pathway

ProteinAtlas SubcellularLocation Main location: Nucleus but not nucleoli; Other location: Cytoskeleton (Microtubules); Expression type: Staining; Reliability: Uncertain

Rattus norvegicus Chromosome position 1q36

Ensembl Gene ID ENSG00000102882

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: appendix; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: appendix; Cell type: lymphoid tissue; Level: Low; Expression type: APE; Reliability: Medium
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: breast; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: cerebellum; Cell type: cells in granular layer; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Low; Expression type: APE; Reliability: Medium
Tissue: cerebellum; Cell type: Purkinje cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: cerebral cortex; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cervix, uterine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: colon; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: duodenum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: epididymis; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: fallopian tube; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: gall bladder; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: heart muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: hippocampus; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: hippocampus; Cell type: neuronal cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: kidney; Cell type: cells in glomeruli; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: kidney; Cell type: cells in tubules; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lateral ventricle; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: lateral ventricle; Cell type: neuronal cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: liver; Cell type: bile duct cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: liver; Cell type: hepatocytes; Level: Low; Expression type: APE; Reliability: Medium
Tissue: lung; Cell type: macrophages; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lung; Cell type: pneumocytes; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lymph node; Cell type: germinal center cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lymph node; Cell type: non-germinal center cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: ovary; Cell type: follicle cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: ovary; Cell type: ovarian stroma cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: pancreas; Cell type: exocrine glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: pancreas; Cell type: islets of Langerhans; Level: High; Expression type: APE; Reliability: Medium
Tissue: parathyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: placenta; Cell type: decidual cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: placenta; Cell type: trophoblastic cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: prostate; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: rectum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: salivary gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: seminal vesicle; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: skeletal muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: small intestine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: spleen; Cell type: cells in red pulp; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: spleen; Cell type: cells in white pulp; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: stomach, lower; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: stomach, upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: testis; Cell type: cells in seminiferus ducts; Level: High; Expression type: APE; Reliability: Medium
Tissue: testis; Cell type: Leydig cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: thyroid gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Medium
Tissue: tonsil; Cell type: germinal center cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: tonsil; Cell type: non-germinal center cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: tonsil; Cell type: squamous epithelial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: urinary bladder; Cell type: urothelial cells; Level: High; Expression type: APE; Reliability: Medium
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Low; Expression type: APE; Reliability: Medium
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: vagina; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: High; Expression type: APE; Reliability: Medium

LocatorString pmquery:egfr+transactivation
pmftq:achondroplasia
gscquery:achondroplasia

Danio rerio Chromosome position LG 3