URN | urn:agi-llid:23765 |
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Total Entities | 0 |
Connectivity | 1046 |
Name | IL17RA |
Description | interleukin 17 receptor A |
Notes | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
ObjectType | Protein |
Pathway | Natural Killer Cell Precursor -> Natural Killer Cell Surface Expression Markers |
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IL17 Signaling in Psoriasis | |
Proteins Involved in Helicobacter Infections | |
Eosinophil Survival in Asthma | |
Il17 Signaling Related Neutrophilia in Asthma | |
IL17F Signaling in Bronchial Epithelial Cell in Asthma | |
Synovial Fibroblast Activation in Psoriatic Arthritis | |
Keratinocyte Activation in Psoriatic Arthritis | |
Proteins Involved in Psoriatic Arthritis | |
Proteins Involved in Endometriosis | |
Cytokines Trigger Otitis Media | |
IL23A and IL17A Provoke Cancer-Associated Inflammation | |
sars-cov binding | |
2_Interleukin-17 and interleukin-22 signaling in psoriasis | |
2_3_Eosinophilia and neutrophilia in asthma: Neutrophil chemotaxis and activation | |
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis | |
Interleukin-17 and interleukin-22 signaling in psoriasis |
Group | Genes with Mutations Associated with Psoriatic Arthritis |
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binding partnetrs for SARSs |
MedScan ID | 23765 |
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LocusLink ID | 23765 |
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16172 | |
312679 |
Alias | Cdw217 |
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IL17 receptors | |
IL17R | |
interleukin 17 receptor A | |
interleukin IL17 receptors | |
LOC150166 | |
IL17 receptor | |
VDw217 | |
interleukin IL17A receptor | |
HIL-17R | |
GNB:2826476 | |
interleukin IL17 receptor A | |
CANDF5 | |
interleukin IL17R | |
interleukin IL17 receptor | |
IL17RA | |
LOC100506204 | |
MGC10262 | |
AW538159 | |
interleukin IL17RA | |
interleukin 17 receptor | |
CD217 | |
IMD51 | |
IL-17 receptor A | |
interleukin 17A receptor | |
interleukin 17 receptors | |
IL-17RA | |
interleukin-17 receptor A |
GO ID | 0030368 |
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0005102 | |
0007166 | |
0050832 | |
0072537 | |
0071621 | |
0097400 | |
1900017 | |
2000667 | |
0032747 | |
2000664 | |
0005576 | |
0005887 | |
0005886 | |
0071345 | |
0050729 | |
0016021 | |
0016020 | |
0019221 |
KEGG ID | hsa:23765 |
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mmu:16172 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 6 56.95 cM |
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OMIM ID | 605461 |
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613953 |
Rat chromosome position | 4q42 |
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Hugo ID | 5985 |
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HGNC:5985 |
Human chromosome position | 22q11.1 |
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Swiss-Prot Accession | Q96F46 |
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Q96F46.2 | |
Q60943 | |
Q60943.1 | |
D4A740 | |
O43844 | |
Q20WK1 |
Swiss-Prot ID | I17RA_HUMAN |
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I17RA_MOUSE |
Cell Localization | Cell membrane |
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Secreted | |
Membrane | |
Plasma membrane |
Ensembl ID | ENSG00000177663 |
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ENSP00000479970.1 | |
ENST00000612619.1 | |
ENSP00000320936.6 | |
ENST00000319363.10 | |
ENSMUSG00000002897 | |
ENSMUSP00000002976.3 | |
ENSMUST00000002976.4 | |
ENSRNOG00000011153 | |
ENSRNOP00000014885.6 | |
ENSRNOT00000014885.6 | |
ENSP00000479970 | |
ENST00000612619 | |
ENSP00000320936 | |
ENST00000319363 | |
ENSMUSP00000002976 | |
ENSMUST00000002976 | |
ENSRNOP00000014885 | |
ENSRNOT00000014885 |
MGI ID | MGI:107399 |
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RGD ID | 1306559 |
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Unigene ID | Hs.48353 |
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Mm.4481 | |
Rn.106209 |
Homologene ID | 7378 |
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Shape | Stick-vertex |
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