Protein CXCL5

URN urn:agi-llid:6374
Total Entities 0
Connectivity 1577
Name CXCL5
Description chemokine (C-X-C motif) ligand 5
Notes This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
Primary Cell Localization Extracellular
Class Ligand

Pathway CXC Chemokine Receptor Signaling
Neutrophil Chemotaxis
Proteins Involved in Atherosclerosis
Proteins Involved in Myocardial Ischemia
IL17 Signaling in Psoriasis
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Insulin Resistance in Myocytes Induced by Obesity
Adipose Tissue Inflammation Provokes Insulin Resistance
Cytokines Trigger Otitis Media
Endothelial Cell Dysfunction in Pyelonephritis
CXCL5 Expression Targets
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of microvessel density
Neighbors of neutrophil count
Neighbors of exhaustion
Neighbors of tumor grade
Neighbors of body mass index
Neighbors of carotid intima-media thickness
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of microvessel density
Neighbors of neutrophil count
Neighbors of exhaustion
Neighbors of tumor grade
Neighbors of body mass index
Neighbors of carotid intima-media thickness
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of tissue remodeling
Neighbors of endothelial cell proliferation
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of lipid storage
Neighbors of cell motility
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of hemopoiesis
Neighbors of T-cell function
Neighbors of lung development
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of myocardial infarction
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of insulin resistance
Neighbors of infection
Neighbors of renal injury
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of death
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of melanoma
Neighbors of cartilage degeneration
Neighbors of cardiovascular disease
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of prostate cancer
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of microglia
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of mesothelial cell
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of leukocyte
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of mast cell
Neighbors of neuroglia
Neighbors of podocyte
Neighbors of phagocyte
Neighbors of retina cell
Neighbors of lung
Neighbors of liver
Neighbors of lymph node
Neighbors of colon
Neighbors of bone
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of brain
Neighbors of islets of Langerhans
Neighbors of spleen
Neighbors of peritoneum
Neighbors of nasopharynx
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of IL1 family
Neighbors of NFKBI
Neighbors of PI3K
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of TLR
Neighbors of cytokine
Neighbors of interleukin
Neighbors of PDGF
Neighbors of ERK1/2
Neighbors of PKA
Neighbors of NF-AT family
Neighbors of IKBK
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of HIF-1
Neighbors of IL12
Neighbors of fibrinogen
Neighbors of mitogen-activated protein kinase kinase
Neighbors of proteasome endopeptidase complex
Neighbors of SAPK
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of TNF-alpha receptor
comon ps_pos, pprarg_neg targets
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_The role of endothelial cells in pyelonephritis
4_1_Polymorphisms associated with inflammatory bowel diseases
4_2_Insulin resistance: inflammation-related insulin resistance
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 6374

LocusLink ID 6374

Alias small inducible cytokine B5
neutrophil-activating protein 78
C-X-C motif chemokine ligand 5
small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
chemokine (C-X-C motif) ligand V
small inducible cytokine subfamily B (Cys-X-Cys), member 5
ENA-78
small inducible cytokine subfamily B (Cys-X-Cys), member V
ENA-78(1-78)
SCYB5
CXC ligand 5
epithelial derived neutrophil activating factor 78
neutrophil activated peptide 78
C-X-C motif chemokine 5
SZ05_HUMAN
neutophil-activating peptide 78
CXC chemokine LIX
Epithelial-derived neutrophil-activating protein 78
CXCL5 chemokine
neutrophil activating peptide 78
AMCF-IIs
epithelial-derived neutrophil-activating peptide 78
CXCL5
LOC60665
epithelial neutrophil activating factor 78
chemokine (C-X-C motif) ligand 5
SZ05
neutrophil-activating peptide ENA-78
LIX
chemokine CXCL5
chemokine CXC ligand 5
CXC chemokine ligand 5
AMCF-II

GO ID 0008009
0007186
0061844
0007267
0071222
0070098
0006935
0006955
0006954
0030595
0030593
0008284
0007165
0005576
0005615
0045236
0060326
0002446
0002690
0032496

KEGG ID hsa:6374

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Homo sapiens

OMIM ID 600324

Hugo ID 10642
HGNC:10642

Human chromosome position 4q13.3

Swiss-Prot Accession P42830
Q6I9S7
P42830.1
Q96QE1

PIR ID JC2433

GenBank ID NC_000004
NM_002994
NP_002985
AC097709
AAY41005
AF349466
AAK29641
AJ315731
AJ315732
CAC42884
CH471057
EAX05696
FB342965
CAR81483
FB711088
CAS91499
L37036
AAA86426
U12709
AAA62475
AK026546
AK312128
BAG35064
BC008376
AAH08376
BT006807
AAP35453
BU169770
BU626570
CB529782
CR457428
CAG33709
DN992282
X78686
CAA55355
P42830
NC_018915
AMYH02009472
DQ895547
ABM86473
EU176356
ABW03807
AC_000136
ABBA01022994

Swiss-Prot ID CXCL5_HUMAN

Cell Localization Secreted

Ensembl ID ENSG00000163735
ENSP00000296027.4
ENST00000296027.5
ENSP00000296027
ENST00000296027

Unigene ID Hs.89714

Shape Rhomb