Protein MAPK8

URN urn:agi-llid:5599
Total Entities 0
Connectivity 4146
Name MAPK8
Description mitogen-activated protein kinase 8
Notes The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Osteoarthritis
Skin Aging
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
Dopamine Receptors Signaling
Thrombopoietin Receptors Signaling in Platelet Maturation
Toll-like Receptors Act through MYD88-TIRAP Signaling
NOD-like Receptors
TLR4 Signaling in Leukocytes
T-Cell Positive Selection and Neglect Induced Death
T-Cell Central Tolerance
Scavenger Receptors in Platelet Activation
Toll-like Receptors in Sterile Inflammation
MC1R in anti-Inflammatory Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Nociception Expression Targets Signaling
ADRA1A -> IL6 Production
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
PTGER2/3 -> Inflammation-Related Expression Targets
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Apoptosis
Proteins Involved in Atherosclerosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Dendritic Cells Function in Atherosclerosis
Dilated Cardiomyopathy
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Myocardial Remodeling
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Inflammatory Reaction in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
Proteins Involved in Melanoma
IL17 Signaling in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Dendritic Cells Function in Psoriasis
beta-Cell Death in Diabetes Mellitus Type 2
Proteins Involved in Diabetes Mellitus Type 2
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Insulin Resistance in Hepatocytes
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Fatty Acids in Hypertension and Atherosclerosis Development
Proteins Involved in Obesity
Macrophage Dysfunction
OipA Signaling in Helicobacter Pylori Infection
Dendritic Cell Function in Ulcerative Colitis
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Follicular Lymphoma
Osteoclast Activation in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
SERPINA1 Associated Liver Damage
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
TSLP Signaling in Bronchial Epithelial Cell in Asthma
IgE Induces Airway Smooth Muscle Cell Proliferation
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
Osteoclast Activation in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
Dendritic Cell Dysfunction in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Skin Fibrosis
CCR5 Signaling in Macrophages
Apoptosis Block in Infected Cells
TNF Receptor Associated Periodic Syndrome
Cryopyrin (NLPR3) Associated Periodic Syndromes
Majeed Syndrome
ER Stress in Huntington Disease
Proteins Involved in Huntington Disease
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Overexpression After Contraction in Skeletal Muscles in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
Osteoclast Activation in Postmenopause
Proteins Involved in Alzheimer's Disease
Glioma Invasion Signaling
Proteins Involved in Glioma
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Proteins Involved in Parkinson's Disease
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
WNT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
RNase L Signaling in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
ER Stress in Macular Degeneration
Steroids Induced Cataract
MYOC Associated Glaucoma
Proteins Involved in Noise-Induced Hearing Loss
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
Proteins Involved in Hearing Loss
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
T-Cell Cytotoxic Activation
Mucin Hyperproduction in Goblet and Mucous Cells
WNT Signaling in Cystic Kidney Disease
Polycystins Mutation Effects in Cystic Kidney Disease
Proteins Involved in Polycystic Kidney Disease
Proteins Involved in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> AP-1 Expression Targets
Dopamine/Gi Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
Frizzled Receptors -> ARRB1/ARRB2 non-Canonical Signaling
Complement Component GPCRs Signaling
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB2 -> TP53 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FrizzledR -> JUN/PAX2 Signaling
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Apoptosis Block by BCL2 Family Proteins in Cancer
VEGFA Dependent Angiogenesis in Cancer
Inhibition of THBS1 Activates Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
S1P Expression Targets
GPCRs Family -> Expression Targets in Lymphoid System and Blood
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
GNRH2 Expression Targets
EDN1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TGFBR -> AP-1 Signaling
TNF-alpha/TNFRSF1A Signaling
JNK/MAPK Signaling
AXL Receptor Tyrosine Kinase Signaling
VEGF Signaling
EGFR Signaling
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
HRAS Signaling
TGFA -> TP53 Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF6 -> DDIT3 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> SPI1 Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
TLR9 Expression Targets
TLR -> AP-1 Signaling
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
WNT1 Expression Targets
WNT3A Expression Targets
WNT4 Expression Targets
WNT5A Expression Targets
WNT7A Expression Targets
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Formation of cysts in polycystic kidney disease
2_Podocyte dysfunction in glomerulonephritis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_MYOC-associated glaucoma
3_Endoplasmic reticulum stress in age-related macular degeneration
2_Pathogens stimulate mucins expression in the middle ear
2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
2_Lipotoxicity in NAFLD
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
2_SERPINA1-associated liver damage
2_Neuron and Schwann cell death
HRAS->RAF->MAPK1/3
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Ageing (non-Mammalian Animal Model)

Source GO component
ResNet
curated

MedScan ID 5599

LocusLink ID 5599
26419
116554
71973
539941
19098
105560
445436
326419
65236
50656
102478

Alias OTTMUSP00000019791
c-Jun N-terminal kinase 1
SAPK1/JNK
p46JNK1
OTTHUMP00000019558
p54 gamma
OTTHUMP00000019556
MAP kinase 8
stress-activated protein kinase JNK I
mitogen-activated protein kinase 8 isoform JNK1 beta2
Jun NH2-terminal kinase I
AI849689
protein kinase JNK1
protein kinase JNK I
stress-activated protein kinase JNK1
JNK1A2
stress-activated protein kinase 1
JNK21B1/2
OTTHUMP00000019552
JNK1 beta protein kinase
mitogen activated protein kinase 8
SAPK I
SAPK1
JNK I
Jun NH2-terminal kinase 1
JNK1
stress-activated protein kinase 1c
PRKM8
OTTMUSP00000019794
JNK1 alpha2 protein kinase
mitogen-activated protein kinase 8 isoform JNK1 alpha1
cJun N-terminal kinase 1
c-Jun NH2-kinase 1
c-Jun NH2-terminal kinase 1
PIR:A53063
OTTMUSP00000019790
mitogen activated protein kinase VIII
SAPK gamma
OTTMUSP00000019793
OTTHUMP00000019555
JNK1 beta1 protein kinase
c-Jun NH2-terminal kinase I
protein kinase mitogen-activated 8
MAPK8
JNK-46
protein kinase mitogen-activated VIII
SAPK1/c-Jun N-terminal kinase
JNK1 alpha protein kinase
SAPK1c
stress activated protein kinase 1
c-Jun N-terminal kinase I
JNK
JUN N-terminal kinase
mitogen-activated protein kinase 8
MAPK 8
c-jun NH2-terminal kinase
Jun NH2-terminal kinase
c-Jun N-terminal kinase
c-Jun NH2-kinase
cJun N-terminal kinase
Stress-activated protein kinase JNK1
Stress-activated protein kinase JNK I
RBPMS2
JNK1alpha2
expressed sequence AI849689
RBPMS2s
JNK1-alpha-1
RNA-binding protein with multiple splicing II
similar to RIKEN cDNA 2400008B06
expressed sequence ai316523
Pristane induced arthritis QTL 1
Pristane induced arthritis QTL I
mitogen-activated protein kinase 8 transcript variant II
Pia I
mitogen-activated protein kinase 8 transcript variant 2
Pia1
RNA-binding protein with multiple splicing 2
scaffold
chromosome
zgc:112379

EC Number 2.7.11.24
2.7.1.-
2.7.11.1
2.7.1.37

GO ID 0005524
0004705
0004707
0019899
0042826
0035033
0016301
0004674
0038095
0007254
0007258
0034198
0071276
0071345
0071222
0071260
0071310
0034614
0035556
0043066
0032091
0048666
0018105
0018107
0043065
0031281
0090045
0010628
1900740
0051247
0006468
1902595
0051090
0042752
0010468
0031063
0016241
0032880
0009411
0009612
0048511
0051403
0030424
0097441
0005737
0005829
0005739
0043005
0005654
0005634
0019894
0000166
0004672
0004712
0016740
0070301
0071732
0048813
0048263
0006954
0001764
0031175
0097150
0001503
0016310
0045740
2001235
0010666
0030335
2000017
0034352
0031116
0002052
0043525
2001224
0071803
0031398
1901485
0097300
0061833
0046605
0045664
0006355
0046686
0009408
0042542
0006970
0007165
0097050
0032839
0043204
0002102
0031982
0000165
1904646
0071347
0034349
0048545
0006950
0071216
0005622
0002755
0002756
0035666
0006915
0097190
0045087
0097193
0048011
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0016772
0008063
0008633
0034130
0023014
0033267
0008624
0008629
0031558
0008152
0005515
0006928
0046933
0004682
0050775
0016469
0004713
0046961
0004691
0015986
0003723
0003676

KEGG ID hsa:5599
mmu:26419
rno:116554

MedLine Reference 16491099
16938889
12869527
12213570
11927625
16412424
12135322
16458303
15642137
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15665513
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11042159
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16815888
11812769
14765123
16336220
17317777
16607699
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15545623
14985505
1748630
16260419
11323415
11489891
15334056
11466342
11062067
16446354
14707549
11606564
9621077
17333127
16282329
12859962
15358865
7642542
11279197
12130508
10597297
14532003
12503078
9207092
12847227
14499647
8177321
12668503
9030579
15769735
16514068
15731347
9096336
14563325
17015619
16807293
12161171
15474087
11788583
16645635
10498280
12397601
16311603
17608927
8889548
16105650
12661038
11749722
12354774
16085647
17325051
10913135
10471813
16814421
11260070
16687575
10995439
15772134
15528994
10772775
16507367
12700162
16099428
17061159
9129988
17108173
14557276
16794185
16971530
9732264
12039864
14500675
16491125
10912793
12763138
12058026
12853963
15483136
15466414
12058028
12161751
11283254
10551811
16483929
11157052
11278789
12079429
16381010
15673436
16973625
17410600
15316358
15778365
17079291
12592382
14699155
16469705
17229766
16314504
12351658
16802349
15757900
12095152
17041759
16927023
17068110
14633134
16774848
9393873
12091388
12477932
15655348
10349636
14688370
15516492
15797868
15820682
15632024
17555943
17283057
9195981
14712227
14578290
16243842
15254243
12376107
11350938
11278799
10559486
10747973
15837794
11432831
12970181
17015265
10629060
15260977
17003331
15272135
15637062
17496921
8654373
12171600
12591950
14637155
16687404
17284179
8621542
16824735
15981086
11238452
8917518
11406125
11076861
11602244
17303384
16153436
17337450
12140754
15711095
15890690
10230788
10391943
17481915
12351702
12665585
14504284
15689551
17045576
9788880
12933347
17074809
17079781
16895791
17192257
17225125
12418963
17699753
16000625
17117477
16113653
17644613
16648634
9405416
16283431
11057897
9670954
11525743
8586671
17478078
12650921
11790792
12052834
10446219
14981905
15608632
10521505
16086581
14517246
9211903
12562529
11435459
17591974
16597616
16407310
14991847
10922068
10585392
17583725
10567572
17251057
15591151
12223406
14514687
12912917
12717433
17699782
14729602
14643766
17065197
16771680
12417588
12939259
10946297
15356200
12606754
16557301
11912216
16307741
14657393
10722755
16055088
11971973
10811224
17015681
16135819
16456712
12707267
12808090
11888903
17296730
12391307
10490659
14701702
12857751
17545598
8137421
9851932
12121974
16217033
16676075
14757751
9223324
16434970
7737129
15629131
12167088
15093613
15733859
9733513
12756228
16902157
10756100
15302935
15145937
14704147
9396779
15572149
12148599
11948398
15030387
17187786
16569638
16618812
12646564
16983342
16339571
16699726
9199329
12869386
16005241
17158878
15911351
16581800
16955144
15778501
15059850
12865320
17178870
16777978
12421945
17078934
15456887
12839624
12206715
17287517
12818176
16141073
12359245
16141072
12538493
12689591
15345747
10601313
15569856
16606357
12143039
12734330
12902351
16624865
16760468
16246848
15542843
11865055
9889198
14724588
14638694
16166642
15693750
15192112
17270352
12011047
11781324
15350216
15860507
12810082
16396984
11983683
10799874
16081837
16627484
11525649
16166651
12646240
9661668
12756254
12620934
12225289
11846446
16972261
16043490
10509564
17050683
12878610
17550900
15739188
17255354
12138158
15567863
12023963
12576423
17143273
12897243
7737130
16699462
15225643
14561739
16942465
17301033
10713157

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Bos taurus
Human

Mouse chromosome position 14
14 B

OMIM ID 601158
OMIM:601158
61411

Rat chromosome position 16p16

Hugo ID 6881
HGNC:6881

Human chromosome position 10q11.22

Swiss-Prot Accession A1L4K2
P45983
P45983.2
A6P3E4
Q7TSJ7
G3X8U9
Q544A0
Q91Y86
Q91Y86.1
P49185
P49185.1
B5BTZ5
B7ZLV4
D3DX88
D3DX92
Q15709
Q15712
Q15713
Q308M2
MK08_MOUSE
Q544A0_MOUSE
MK08_HUMAN
A1L4K2_HUMAN
B5BTZ5_HUMAN
B7ZLV4_HUMAN

PIR ID S71097
S71099
S43970

GenBank ID NC_000010
NR_136583
NR_136584
NR_136585
NM_001278547
NP_001265476
XM_024448079
XP_024303847
NM_001323302
NP_001310231
NM_139049
NP_620637
NM_139046
NP_620634
NM_001323322
NP_001310251
NM_001323327
NP_001310256
NM_001323331
NP_001310260
NM_001323325
NP_001310254
NM_001323330
NP_001310259
NM_001323326
NP_001310255
NM_001323328
NP_001310257
NM_001323323
NP_001310252
NM_001323324
NP_001310253
NM_001323329
NP_001310258
NM_001323321
NP_001310250
NM_001323320
NP_001310249
XM_024448080
XP_024303848
NM_001278548
NP_001265477
NG_029053
AC016397
AC074325
CH471187
EAW93129
EAW93130
EAW93131
EAW93132
EAW93133
EAW93134
EAW93135
EAW93136
EAW93137
EAW93138
AA808177
AB074280
AB451231
BAG70045
AB451271
BAG70085
AB451354
BAG70168
AB451398
BAG70212
AK094000
AK125150
AK292523
BAF85212
AL137667
BC130570
AAI30571
BC130572
AAI30573
BC144063
AAI44064
DA159335
DQ234352
ABB29981
L26318
AAA36131
U34822
AAC50607
U35004
AAC50610
U35005
AAC50611
P45983
NC_000080
NM_001310453
NP_001297382
NM_001310454
NP_001297383
NM_016700
NP_057909
NM_001310452
NP_001297381
XM_006519032
XP_006519095
AC154649
CH466573
EDL24852
EDL24853
EDL24854
EDL24855
EDL24856
EDL24857
EDL24858
AB005663
BAA85875
AB206575
BAF48661
AB219977
BAF69037
AI849689
AK030767
AK032486
AK039129
AK039254
AK043102
BAC31460
AK044768
AK047936
AK053062
AK085745
AK139498
AK162915
BB619635
BC053027
AAH53027
CD803749
Q91Y86
NC_005115
NM_053829
NP_446281
AC_000084
AABR07024624
AABR07024625
AABR07024626
AABR07024627
AAHX01086374
AAHX01086375
AAHX01086376
CH474046
EDL88899
EDL88900
EDL88901
EDL88902
AA963835
CB782828
DV724511
EU253566
ABX46062
FM076271
KJ160388
AIZ76559
L27129
AAA42111
P49185
XM_011539954
XP_011538256
XM_011539958
XP_011538260
XM_011539956
XP_011538258
XM_011539957
XP_011538259
XM_011539953
XP_011538255
XM_011539955
XP_011538257
NM_002750
NP_002741
NC_018921
AMYH02022973
AMYH02022974
HQ258413
ADR83167
XM_006519031
XP_006519094
XM_006519030
XP_006519093
XM_006519033
XP_006519096
AC_000036
AAHY01112710
AAHY01112711
AAHY01112712
XM_006717919
XP_006717982
XM_006717917
XP_006717980
XM_006717918
XP_006717981
AC_000142
ABBA01047222
XM_005269973
XP_005270030
XM_005269974
XP_005270031
XM_005269977
XP_005270034
XM_005269976
XP_005270033
XM_005269975
XP_005270032
AABR06086523
AABR06086524
AABR06086525
AABR06086526
NM_139047
NP_620635
XM_341399
XP_341400
XM_001056513
XP_001056513
NT_030059
NW_924685
NW_001837974
AC_000053
CR614448
Q308M2
NT_039606
NW_001030543
Q544A0
Q7TSJ7
NW_047469
NW_001084711
NT_017696
1082748
H3066H10-3
26335518
20986518
20986519
XP_879071
26335519
31418523
20986521
31418524
20986520
20986523
20986522
30316121
NT_039598
XP_869760
26087040
26090526
BM940281
493212
493213
127058150
81887723
A53063
BG081594
AAH95795
34877248
22653814
26092533
NM_131721
H3073D04-3
Q9DGD9
NC_007329
120659944
148692910
148692911
148692906
148692905
148692908
148692907
148692909
2507195
149034131
149034132
9836506
XP_001250450
AI316523
149034130
31980670
Q502A0
121948371
BC095795
7710060
XP_001250405
119613543
119613542
119613544
119613541
119613540
NW_000091
26095546
63100957
NW_001494477
120660426
1346337
119613539
119613538
119613537
119613536
119613535
XM_864667
82192608
D730034N23
BG068565
XM_001250449
474901
BG069159
474900
5730585A15
1463136
1463137
BAB11810
1463138
1463139
XM_873978
AB030900
1463131
1463130
149034129
6807833
78191533
AW909414
4506095
BB184171
51468195
NW_001510856
51768363
NP_571796
151175626
XM_001250404
BG082181
34877033
34877032
29737804
6141551
6141550
NC_007123
26086964
81894687
20986493
NT_086769
NP_082306
BC021788
BAE33785
AK010301
NT_039474
AK144659
NC_000075
BAB26834
AAH21788
NM_028030
BAE25995
AK156633

Swiss-Prot ID MK08_HUMAN
MK08_MOUSE
MK08_RAT
Q544A0_MOUSE
A1L4K2_HUMAN
B5BTZ5_HUMAN
B7ZLV4_HUMAN
D3DX92_HUMAN
D3DX88_HUMAN

Cell Localization Cytoplasm
Nucleus
Extracellular

Ensembl ID ENSG00000107643
ENSP00000378974.4
ENST00000395611.7
ENSP00000353483.4
ENST00000360332.7
ENSP00000363297.3
ENST00000374182.7
ENSP00000363304.1
ENST00000374189.5
ENSP00000363294.3
ENST00000374179.8
ENSMUSG00000021936
ENSMUSP00000107574.1
ENSMUST00000111943.7
ENSMUSP00000022504.5
ENSMUST00000022504.11
ENSMUSP00000107575.3
ENSMUST00000111944.9
ENSMUSP00000107576.2
ENSMUST00000111945.8
ENSRNOG00000020155
ENSRNOP00000062048.3
ENSRNOT00000065216.3
ENSP00000378974
ENST00000395611
ENSP00000353483
ENST00000360332
ENSP00000363294
ENST00000374179
ENSP00000363304
ENST00000374189
ENSMUSP00000107576
ENSMUST00000111945
ENSMUSP00000022504
ENSMUST00000022504
ENSMUSP00000107575
ENSMUST00000111944
ENSMUSP00000107574
ENSMUST00000111943
ENSRNOP00000062048
ENSRNOT00000065216
ENSP00000363297
ENST00000374182
ENSP00000363291
ENST00000374176

MGI ID MGI:1346861
1346861
1328367
2143015
2145699

RGD ID 621506
61411

Unigene ID Hs.138211
Hs.522924
Mm.21495
Rn.4090
Rn.160441
Mm.441782
Hs.445864
Bt.14050
Hs.267445
Dr.82505

Homologene ID 56760

Shape Sickle-vertex

IPI ID IPI00129682
IPI00191803
IPI00003145
IPI00024672
IPI00220305
IPI00220306
IPI00854859
IPI00646929
IPI00639865
IPI00857698
IPI00775848
IPI00775931
IPI00775897
IPI00776030
IPI00764183

Chromosome position 14 B
9 C
16p16
10q11.22

Microarray ID 104047_at
100391_at
A_52_P559044
A_65_P05523
56901_at
84382_at
H3066H10-3
A_14_P122151
A_43_P15745
2070_i_at
rc_AI029013_at
A_51_P422342
AK047936
A_65_P05437
2071_s_at
L27129_at
A_23_P356152
136576_r_at
702
L26318
R637
1420932_at
229664_at
OH7871
A_23_P202540
I_932382
226046_at
NM_016700
NM_002750.2
L27129.1
A_14_P128899
34006_s_at
210671_x_at
U35005_s_at
1437045_at
A_24_P286898
1420931_at
A_51_P357182
A_52_P657817
170626_i_at
226048_at
132248_r_at
210477_x_at
A_14_P107815

Homo sapiens Chromosome position 10q11.22

Ensembl Transcript ID ENST00000374176
ENST00000374182
ENST00000374179
ENST00000374189
ENST00000360332

ENSEMBL ENSG00000107643

FunctionalClass protein kinase
MAP kinase
hydrogen-transporting ATP synthase activity, rotational mechanism
nucleotide binding
hydrogen ion transporting ATPase activity, rotational mechanism
kinase
protein binding
protein-tyrosine kinase
protein kinase CK2
JUN kinase
hydrogen ion transporting ATP synthase activity, rotational mechanism
protein serine/threonine kinase
transferase
hydrogen-transporting ATPase activity, rotational mechanism
ATP binding
cAMP-dependent protein kinase
RNA binding
nucleic acid binding

Hugo Symbol MAPK8

Bos taurus Chromosome position 28

Mus musculus Chromosome position 14 B
9
14

KEGG pathway Insulin signaling pathway
Type II diabetes mellitus
Focal adhesion
Wnt signaling pathway
Toll-like receptor signaling pathway
Colorectal cancer
Pancreatic cancer
MAPK signaling pathway
ErbB signaling pathway
GnRH signaling pathway
Fc epsilon RI signaling pathway
Adipocytokine signaling pathway

State isoform 4
isoform 3
isoform 2
isoform 1
p

Rattus norvegicus Chromosome position 16p16

Ensembl Gene ID ENSG00000107643

Keyword map kinase
RNA
map kinase kinase
nuclei
ERK activator kinase
PKC
phosphotransferase
SAP kinase
protein phosphatase
nucleus
synaptosome
map kinases

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: lymphoid tissue; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: breast; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: cells in granular layer; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cervix, uterine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: colon; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: duodenum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: epididymis; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: fallopian tube; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: gall bladder; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: heart muscle; Cell type: myocytes; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: kidney; Cell type: cells in glomeruli; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: kidney; Cell type: cells in tubules; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: bile duct cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: hepatocytes; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: macrophages; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: ovary; Cell type: ovarian stroma cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: islets of Langerhans; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: parathyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: placenta; Cell type: trophoblastic cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: prostate; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: rectum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: salivary gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: seminal vesicle; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: skeletal muscle; Cell type: myocytes; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: small intestine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in red pulp; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: stomach, lower; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: stomach, upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: thyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: urinary bladder; Cell type: urothelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: vagina; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain

LocatorString pmquery:curcumin+prostate+cancer
pmquery:curcumin prostate cancer
gscquery:curcumin+prostate+cancer

State Description Transcript Variant: This variant (1) is also known as JNK1 alpha1. It encodes the longest isoform (1).
Transcript Variant: This variant (2) is also known as JNK1 alpha2. It contains extra 5 nt within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (2) thus contains a distinct and shorter C-te...
Transcript Variant: This variant (3) is also known as JNK1 beta 1. It contains a different segment, and extra 5 nt within the coding region, when compared to variant 1. The extra 5 nt leads to a translation frameshift, and results in an isoform (1) tha...
Transcript Variant: This variant (4) is also known as JNK1 beta2. It contains a different segment within the coding region when compared to variant 1. The translation remains in-frame, and results in an isoform (4) that contains a different internal se...