Pathway
|
Alzheimer's Disease
|
|
Osteoarthritis
|
|
Skin Aging
|
|
mTOR Signaling
|
|
mTOR Signaling Hyperfunction
|
|
Insulin Influence on Protein Synthesis
|
|
Insulin Influence on Glycogenesis
|
|
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
|
|
Insulin Signaling
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
T-Cell Dependent B-Cell Activation
|
|
Natural Killer Cell Activation through C-Type Lectin-like Receptors
|
|
Natural Killer Cell Activation through ITAM-Containing Receptors
|
|
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
|
|
T-Cell Maturation (Hypothesis)
|
|
Natural Killer Cell Activation
|
|
T-Cell Positive Selection and Neglect Induced Death
|
|
T-Cell Central Tolerance
|
|
CD8+ T-Cell Activation
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Platelet Activation via Adhesion Molecules
|
|
Proplatelet Maturation
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
Macrophage M2-Related Phagocytosis
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
Neutrophil Recruitment and Priming
|
|
Neutrophil Degranulation via FPR1 Signaling
|
|
Neutrophil Chemotaxis
|
|
Negative Acute Phase Proteins Synthesis
|
|
Positive Acute Phase Proteins Synthesis
|
|
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Dendritic Spine Morphogenesis and Stabilization
|
|
Nociception Expression Targets Signaling
|
|
NTSR1 Expression Targets
|
|
DRD2 Expression Targets
|
|
CHRM1 -> IL2 Production
|
|
IL6 Expression Targets -> Nociception
|
|
CHRNA7 -> NOS1 Production
|
|
Vitamine D Deficite and Dentin Formation
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Arterial Hypertension
|
|
Endothelial Cell Dysfunction in Arterial Hypertension
|
|
Smooth Muscle Cell Dysfunction in Arterial Hypertension
|
|
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
|
|
Myocardial Remodeling
|
|
Sebocyte Proliferation in Acne Vulgaris
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Hair Follicle Keratinocyte Apoptosis
|
|
Androgens in Sebocyte Maturation
|
|
Atopic Dermatitis Onset
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
IL22 Induces Keratinocyte Proliferation in Psoriasis
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
CD8+ T-Cell Response to Self-Determinants in Diabetes
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Donohue Syndrome Progression (Hypothesis)
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
Adiponectin Synthesis Declines in Insulin Resistance
|
|
Insulin Resistance in Hepatocytes
|
|
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
|
|
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
|
|
RET1 Mutation in Hyperparathyroidism
|
|
Cardiovascular Effects in Hyperthyroidism
|
|
CD4+T-Cell Response in Celiac Disease
|
|
CD8+ T-Cell Response in Celiac Disease
|
|
Celiac Disease
|
|
Cetuximab Resistance in Colorectal Cancer
|
|
Metastatic Colorectal Cancer
|
|
CagA Phosphorylation Dependent Signaling
|
|
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
FLT3/KIT/MLL Signaling in Leukemia
|
|
Apoptosis Block in Acute Myeloid Leukemia Cell
|
|
RARA Signaling in Acute Myeloid Leukemia (M3)
|
|
Acute Myeloid Leukemia
|
|
Myeloid Cell Differentiation Block in Leukemia
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Follicular Lymphoma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Pancreatic Ductal Carcinoma
|
|
Growth Factor Signaling in Pancreatic Neoplasms
|
|
Pancreatic Neuroendocrine Tumors
|
|
TGFBR Signaling in Pancreatic Neoplasms
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Goblet-Cell Related Mucus Secretion in Asthma
|
|
Basophil Activation in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Antigen-Presenting Cell Role in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
Steroidogenesis Impairement in Polycystic Ovary Syndrome
|
|
Polycystic Ovary Syndrome
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
|
|
CD4+ T-Cell Function Decline in HIV
|
|
CD4+ T-Cell Death in HIV
|
|
Estrogen Effects on Pregnancy Gingivitis
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
Cowden Syndrome
|
|
Gluten Impact on Neuronal System (Hypothesis)
|
|
Rett Syndrome
|
|
IL6 Promotes Inflammation in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
|
|
Osteoblast Function Decline in Osteoporosis
|
|
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
|
|
Glioblastoma, Primary
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Glioma Invasion Signaling
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Breast Cancer
|
|
Endometrial Cancer
|
|
Endometrioid Endometrial Cancer
|
|
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
|
|
Angiogenesis in Endometriosis
|
|
Leptin Role in Endometriosis
|
|
Endometrioid Ovarian Carcinoma
|
|
Clear Cell Ovarian Carcinoma
|
|
EGFR and PTAFR Signaling in Ovarian Cancer
|
|
High-Grade Serous Ovarian Carcinoma
|
|
Low-Grade Serous Ovarian Carcinoma
|
|
Ovarian Cancer
|
|
Mucinous Ovarian Carcinoma
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
Prostate Cancer
|
|
Steroids Induced Cataract
|
|
Glutamate Mediated Excitotoxicity in Glaucoma
|
|
Cytokines Trigger Otitis Media
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
Mesangial Cell Dysfunction in Glomerulonephritis
|
|
Interstitial Fibroblasts in Pyelonephritis
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
AREG -> CREB/CREBBP Expression Targets
|
|
AREG -> NCOR2 Expression Targets
|
|
AREG -> SMAD1 Expression Target
|
|
AREG -> HIF1A Expression Targets
|
|
AREG -> AP-1 Expression Targets
|
|
Noreadrenaline/Gq Expression Targets
|
|
Acetylcholine Expression Targets
|
|
Epinephrine/Gq Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
BTC -> AP-1/ATF/CREB Expression Targets
|
|
BTC -> EP300/ETS/ETV/SP1 Expression Targets
|
|
SELE -> ELK-SRF Signaling
|
|
CD247 Expression Targets
|
|
FCGR3A Expression Targets
|
|
CD72 -> CREB/CREBBP Expression Targets
|
|
CD8 -> ATF/CREB/CREBBP Expression Targets
|
|
CD80 -> NF-kB Expression Targets
|
|
CD86 -> NF-kB Expression Targets
|
|
CHRNA7 -> CREB Signaling
|
|
EGF -> HIF1A Expression Targets
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
EGF -> TP53 Expression Targets
|
|
EGF -> NCOR2 Expression Target
|
|
EGFR -> NCOR2 Signaling
|
|
EGFR/ERBB2 -> TP53 Signaling
|
|
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
|
|
EGFR -> SMAD1 Signaling
|
|
EGFR/ERBB2 -> HIF1A Signaling
|
|
EGFR -> AP-1/ATF2 Signaling
|
|
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
|
|
EREG -> CREB Expression Target
|
|
EREG -> EP300/SP1 Expression Targets
|
|
EREG -> HIF1A Expression Target
|
|
EREG -> AP-1/ATF Expression Targets
|
|
Erythropoietin -> ELK/SRF Expression Targets
|
|
PECAM1 Expression Targets
|
|
NCAM1 Expression Targets
|
|
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
FGF9 -> AP-1/CREB/MYC Expression Targets
|
|
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
FGF1 -> NCOR2 Expression Target
|
|
FGF7 -> RUNX Expression Targets
|
|
FGF8 -> AP-1/CREB/MYC Expression Targets
|
|
FGF1 -> RUNX Expression Targets
|
|
FGF18 -> AP-1/CREB Expression Targets
|
|
FGF23 -> NCOR2 Expression Targets
|
|
FGF8 -> RUNX Expression Targets
|
|
FGF9 -> RUNX Expression Targets
|
|
FGF2 -> NCOR2 Expression Targets
|
|
FGF4 -> AP-1/MYC Expression Targets
|
|
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> RUNX Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
FGFR -> RUNX2 Signaling
|
|
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
|
|
Glutamate/Gq Expression Targets
|
|
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
HBEGF -> AP-1/ATF Expression Targets
|
|
HBEGF -> TP53 Expression Targets
|
|
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
|
|
HBEGF -> HIF1A Expression Targets
|
|
HBEGF -> CREB/MYC Expression Targets
|
|
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
HGFR -> AP-1/CREB/MYC Signaling
|
|
TAM Receptor Signaling Activation in Cancer
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
VEGFA Dependent Angiogenesis in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
|
|
Integrins in Cancer Cell Motility, Invasion and Survival
|
|
CDH2 Activation Promotes Cancer Cell Migration and Survival
|
|
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
IGF2 -> HIF1A/MYC Expression Targets
|
|
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
NCAM1 -> CREB/ELK/SRF/MYC Signaling
|
|
PECAM -> SP1 Signaling
|
|
FcIgER -> ELK-SRF Signaling
|
|
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
|
|
InsulinR -> ELK/SRF/SREBF Signaling
|
|
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
|
|
Fibronectin Expression Targets
|
|
CTGF -> AP-1/CREB/MYC Expression Targets
|
|
CTGF -> NCOR2 Expression Target
|
|
IL6R -> CEBP/ELK/SRF Signaling
|
|
IL2R -> ELK/SRF/MYC Signaling
|
|
IL4R -> ELK/SRF/HMGY Signaling
|
|
IL16 -> AP-1 Expression Targets
|
|
IL6 Expression Targets
|
|
IL4 Expression Targets
|
|
IL2 Expression Targets
|
|
UrokinaseR -> ELK/SRF Signaling
|
|
PTPRC -> BCL6 Expression Targets
|
|
Leptin -> ELK/SRF Expression Targets
|
|
LPA Expression Targets
|
|
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
|
|
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
NRG1 -> TP53 Expression Target
|
|
NRG1 -> AP-1/ATF Expression Targets
|
|
NRG1 -> HIF1A Expression Target
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
NGF -> AP-1/TP53/MYC Expression Targets
|
|
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
|
|
NGF -> CREB/CEBPB/MEF2A Expression Targets
|
|
PDGFB -> AP-1/CREB/MYC Expression Target
|
|
PDGFC -> CREB Expression Target
|
|
PDGFD -> AP-1 Expression Targets
|
|
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
KIT -> MITF Signaling
|
|
PDGFR -> AP-1/MYC Signaling
|
|
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
NTS Expression Targets
|
|
AGT -> TP53 Expression Targets
|
|
AGT -> CREB Expression Targets
|
|
AGT -> ELK/SRF Expression Targets
|
|
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
|
|
PDCD1 -> AP-1 Expression Targets
|
|
PTPRC -> BCL6 Signaling
|
|
GDNF -> HSF1 Signaling
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
GAS6 -> AP-1/CREB Expression Targets
|
|
FIGF -> AP-1 Expression Target
|
|
FIGF -> NCOR2 Expression Target
|
|
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
GDNF -> HSF1 Expression Targets
|
|
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
|
|
Ras-GRF Regulation Signaling
|
|
Androgen Receptor non-Genomic Signaling
|
|
FOXO1 Signaling
|
|
MERTK Signaling
|
|
TGF-beta Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
KRAS Signaling
|
|
Estrogens/ESR1 non-Genomic Signaling
|
|
EGFR Signaling
|
|
HRAS Signaling
|
|
TCR -> AP-1 Expression Targets
|
|
T-Cell Receptor -> AP-1 Signaling
|
|
TGFA -> TP53 Expression Targets
|
|
TGFA -> HIF1A Expression Targets
|
|
TGFA/AP-1/ATF Expression Targets
|
|
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
|
|
LTA Expression Targets
|
|
TNF -> AP-1 Expression Targets
|
|
TNF -> ELK-SRF Expression Targets
|
|
TNF -> CREB Expression Targets
|
|
TNF -> TP53/ATF Expression Targets
|
|
TNFRSF1A -> AP-1/ATF/TP53 Signaling
|
|
TNFRSF1A -> CREB/ELK-SRF Signaling
|
|
Thrombopoietin -> SPI1 Expression Targets
|
|
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
Thrombopoietin -> SP1 Expression Targets
|
|
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
|
|
PLAU -> ELK-SRF/AP-1 Expression Targets
|
|
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
|
|
VEGFA -> NFATC Expression Targets
|
|
VEGFC -> ATF Expression Target
|
|
VEGFA -> AP-1/CREBBP/MYC Expression Targets
|
|
VEGFA -> NCOR2 Expression Target
|
|
VEGFR -> NFATC Signaling
|
|
VEGFR -> AP-1/CREB/MYC Signaling
|
|
VEGFR -> ATF/CREB/ELK-SRF Signaling
|
|
New Pathway
|
|
1_Inflammation in keratinocytes in the pathology of acne
|
|
2_Hyperseborrhea in acne vulgaris
|
|
2_Acute phase initiation in atopic dermatitis
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
1_The onset of atopic dermatitis
|
|
1_TNF and IL1B provoke ECM degradation in osteoarthritis
|
|
2_Osteoblast-mediated bone demineralization
|
|
3_The role of interstitial fibroblasts in pyelonephritis
|
|
1_Local estrogen production stimulates ectopic endometrium proliferation
|
|
3_Enhanced angiogenesis in endometriosis
|
|
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
|
|
1_Th2 cell response in asthma
|
|
3_1_Mucus accumulation in asthma
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
1_CD4+ T cell and epithelial cell response in celiac disease
|
|
2_CD8+ T-cell response and mucosal damage in celiac disease
|
|
1_2_Insulin synthesis and secretion: insulin secretion
|
|
1_1_Insulin synthesis and secretion: insulin processing and storage
|
|
4_1_Insulin resistance: insulin signaling
|
|
3_Islet beta-cell destruction in T1D
|
|
2_1_General pathways of thyroid hormone signaling
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|