Protein IL22

URN urn:agi-llid:50616
Total Entities 0
Connectivity 2923
Name IL22
Description interleukin 22
Notes This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]
Primary Cell Localization Extracellular
Class Ligand

Pathway AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
Proteins Involved in Myocarditis
Proteins Involved in Acne Vulgaris
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins Involved in Vitiligo
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Ulcerative Colitis
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
Proteins with Altered Expression in Psoriatic Arthritis
Proteins Involved in Age-Related Macular Degeneration
Elevated Receptors -> Expression Targets in Bone and Joint
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
Proteins with Altered Expression in Tumor-Promoting Inflammation
NOTCH -> Expression Targets in Skin
IL22R -> STAT3 Signaling
IL22 Expression Targets
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
NOTCH -> Expression Targets in Thymus
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of viral load
Neighbors of blood pressure
Neighbors of tumor grade
Neighbors of blood glucose
Neighbors of T-cell count
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of skin thickness
Neighbors of comorbidity
Neighbors of fibroblast phenotype
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of viral load
Neighbors of blood pressure
Neighbors of tumor grade
Neighbors of blood glucose
Neighbors of T-cell count
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of skin thickness
Neighbors of comorbidity
Neighbors of fibroblast phenotype
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of cell motility
Neighbors of fibroblast proliferation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of heart function
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of autophagy
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of renal injury
Neighbors of liver injury
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of collagen-induced arthritis
Neighbors of interstitial fibrosis
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of hypertrophy
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of fibroblast
Neighbors of PBMC
Neighbors of pneumocyte
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of inflammatory cell
Neighbors of neutrophil
Neighbors of bone marrow derived dendritic cell
Neighbors of activated T-cell
Neighbors of mononuclear phagocyte
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cancer-associated fibroblast
Neighbors of stem cell
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of mast cell
Neighbors of spleen cell
Neighbors of hematopoietic cell
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of lymphoid cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of colon
Neighbors of airway
Neighbors of gastrointestinal tract
Neighbors of bone
Neighbors of synovial membrane
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of cardiovascular system
Neighbors of lymphatic system
Neighbors of spleen
Neighbors of lymph node of mesentery
Neighbors of myelin sheath
Neighbors of draining lymph node
Neighbors of mesentery
Neighbors of salivary gland
Neighbors of ileum
Neighbors of small intestine
Neighbors of NF-kB family
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of PI3K
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interleukin
Neighbors of MEK1/2
Neighbors of Ras GTPase
Neighbors of PKA
Neighbors of NF-AT family
Neighbors of LXR
Neighbors of IL23
Neighbors of T-cell receptor
Neighbors of IL1R
Neighbors of IL12
Neighbors of Notch
Neighbors of lectin
Neighbors of interleukin-35
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of immunoglobulin
Neighbors of CD3 complex
Neighbors of RA receptor
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
Overview. Diseases of the skin (chapter 11)
1_Differentiation of psoriatic T cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Inflammatory mediators increase the production of hepcidin (HAMP)
Model of PPARG signaling in psoriais (tested)
Differentiation of psoriatic T cells
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 50616

LocusLink ID 50616
50929
116849
500836

Alias interleukin-22 receptor ligand
IL-TIFbs
interleukin IL-TIF
interleukin IL-TIFb
interleukin IL-10-related T-cell-derived inducible factor
TIFIL-23
IL-10-related T-cell-derived-inducible factor beta
ILTIF
ILTIFa
MGC79382
interleukin-22b
ILTIF alpha
RGD1561292
MGC129416
LOC236012
cytokine Zcyto18
interleukin-22 receptor ligand activity
mCG_123110
UNQ3099/PRO10096
MGC129417
zcyto18
IL-TIF alpha
LOC236571
interleukin IL-10-related T-cell-derived inducible factor alpha
ILTIFb
interleukin IL-D110
IL-TIF beta
T-cell-derived inducible factor alpha
MGC79384
IL-TIF
interleukin 10-related T cell-derived inducible factor beta
IL-TIFa
interleukin IL-TIFa
interleukin-22 receptor ligands
IL-22a
interleukin IL22
interleukin 10-related T cell-derived inducible factor
interleukin 22
Interleukin-22a precursor (IL-22a) (IL-10-related T-cell-derived inducible factor alpha) (IL-TIFa)
IL22
interleukin IL-TIFbs
IL-D110
IL-10-related T-cell-derived inducible factor alpha
IL-10-related T-cell-derived inducible factor
IL-TIFb
interleukin-22a
Il22b
T-cell-derived inducible factor beta
TIFa
IL-21
IL-22
interleukin-22
IL-10-related T-cell-derived-inducible factor
IL-22b
IL21
interleukin 21

GO ID 0005125
0045518
0006953
0019221
0006954
0051384
0005576
0005615
0050728
0045944
0072593
0042509
0010469
0007267
0006955
0046427
0042516

KEGG ID mmu:50929
mmu:116849
hsa:50616
rno:500836

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 10 66.67 cM
10
10 67.0 cM

OMIM ID 605330

Rat chromosome position 7q22

Hugo ID 14900
HGNC:14900

Human chromosome position 12q15

Swiss-Prot Accession Q9GZX6
Q9GZX6.1
Q9JJY9
Q9JJY9.1
Q9JJY8
Q9JJY8.2
G3V6X6
Q14BB3
E9QAL9
Q6NWP4
Q6NZ83
Q6NZ84
Q3SXE1
Q198B4

GenBank ID NC_000012
NM_020525
NP_065386
NG_060763
AC007458
AC022511
AF387519
AAK62468
AJ277248
CAC19409
AX151713
CAC42593
AX179578
CAC49973
AX468783
CAD42564
CH471054
EAW97182
CQ889879
CAH61624
CQ889941
CAH61629
CS425140
CAL60104
CS719533
CAP40185
HC679523
CBL86572
HC888910
CBM42922
JA104587
CCA63963
AF279437
AAG22064
AJ277247
CAC06085
AY358890
AAQ89249
BC066263
AAH66263
BC066264
AAH66264
BC066265
AAH66265
BC066266
BC067509
AAH67509
BC067510
AAH67510
BC069112
AAH69112
BC069308
AAH69308
BC070261
AAH70261
CD559617
CD638517
Q9GZX6
NC_000076
XM_006513865
XP_006513928
NM_016971
NP_058667
AC153856
AJ294727
CAC19435
CH466539
EDL21856
AJ249491
CAB75546
BC104348
AAI04349
BC104349
AAI04350
BC116235
AAI16236
Q9JJY9
NM_054079
NP_473420
AC158600
AJ294728
CAC19436
AJ249492
CAB75547
AK005228
Q9JJY8
NC_005106
NM_001191988
NP_001178917
AC_000075
AABR07057220
AAHX01049469
AAHX01049470
CH473960
EDM16599
DQ630444
ABF82262
NC_018923
AMYH02026693
HQ448427
ADQ32907
AC_000032
AAHY01089284
NW_001074832
AAHY01146294
AC_000144
NT_029419
NW_001838060
NW_925395
AC_000055
Q6NWP4
Q6NZ83
Q6NZ84
NT_039500
NW_001030420
Q3SXE1
XM_576228
XP_576228
NW_001084856
XM_001081002
XP_001081002
NW_047774
Q198B4
XM_005268929
XP_005268986
ABBA01026559

Swiss-Prot ID IL22_MOUSE
IL22B_MOUSE
IL22_HUMAN
E9QAL9_MOUSE
Q14BB3_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000127318
ENSP00000329384.4
ENST00000328087.6
ENSMUSG00000074695
ENSMUSP00000094449.4
ENSMUST00000096691.4
ENSMUSG00000090461
ENSMUSP00000128415.1
ENSMUST00000163808.1
ENSRNOG00000007365
ENSRNOP00000009776.3
ENSRNOT00000009776.4
ENST00000328087.5
ENSP00000329384
ENST00000328087
ENSMUSP00000094449
ENSMUST00000096691
ENSMUSP00000128415
ENSMUST00000163808
ENSRNOP00000009776
ENSRNOT00000009776
ENSP00000442424
ENST00000538666

MGI ID MGI:1355307
MGI:2151139
1355307
2151139

RGD ID 1561292

Unigene ID Mm.103585
Mm.213193
Rn.195879
Hs.287369

Homologene ID 9669

Shape Rhomb

IPI ID IPI00008372
IPI00122408
IPI00953777
IPI00122407
IPI00769042
IPI00475569