Protein FOSL1

URN urn:agi-llid:8061
Total Entities 0
Connectivity 1352
Name FOSL1
Description FOS-like antigen 1
Notes The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway Kidney Cells Cilia Organization
Proteins Involved in Atherosclerosis
X-Linked Ichthyosis
Proteins Involved in non-Alcoholic Fatty Liver Disease
Osteoclast Activation in Multiple Myeloma
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
LPA Expression Targets
CSF1 -> STAT Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
ERK5/MAPK7 Signaling
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TNF -> AP-1 Expression Targets
prarg negative regulators, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative regulators
PPARG negative targets
pparg expr target_regulators
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of tumor size
Neighbors of mortality
Neighbors of clinical stage
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of bone mass
Neighbors of tumor promotion
Neighbors of mortality rate
Neighbors of radioresistance
Neighbors of shear stress
Neighbors of gastric cancer risk
Neighbors of bone volume
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of tumor size
Neighbors of mortality
Neighbors of clinical stage
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of bone mass
Neighbors of tumor promotion
Neighbors of mortality rate
Neighbors of radioresistance
Neighbors of shear stress
Neighbors of gastric cancer risk
Neighbors of bone volume
Neighbors of cell development
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of cell function
Neighbors of cell formation
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of cell adhesion
Neighbors of tumor growth
Neighbors of cell count
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of cell damage
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of adipocyte differentiation
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of cell invasion
Neighbors of ossification
Neighbors of transcription activation
Neighbors of senescence
Neighbors of cell transdifferentiation
Neighbors of stem cell differentiation
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of inflammation
Neighbors of obesity
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of leukocyte infiltration
Neighbors of liver injury
Neighbors of sepsis
Neighbors of death
Neighbors of lung injury
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of neoplasm invasion
Neighbors of heart failure
Neighbors of pulmonary fibrosis
Neighbors of cancer
Neighbors of neoplasm
Neighbors of prostate cancer
Neighbors of osteolysis
Neighbors of adipocyte
Neighbors of lymph node
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of IL1 family
Neighbors of Jun/Fos
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of TLR
Neighbors of cytokine
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of IKBK
Neighbors of protein tyrosine kinase
Neighbors of LXR
Neighbors of p38
Neighbors of PDGF-BB
Neighbors of endothelin
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of WNT
Neighbors of TORC1
Neighbors of PDGF receptor
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
2_Harlequin ichthyosis overview
Model of PPARG signaling in psoriais (tested)
before laser treatment
Anti-psoriatic drugs influence PPARG signaling
PPARG signaling after laser treatment

MedScan ID 8061

LocusLink ID 8061
14283
25445

Alias transcription factor Fra-1
fos-like antigen 1
FOSL I
FOS like 1, AP-1 transcription factor subunit
fos-like antigen I
AW538199
FOS-related antigen 1
Fra-1/AP-1 transcription factor
FOSL1
FRA I
FRA1
FRA1_HUMAN
FOS-related antigen I
Fra-1/AP-1
FRA
fra-1
FOS like 1, AP-1 trancription factor subunit
FOS-like antigen-1

GO ID 0001228
0003700
0000981
0000978
0006968
0031668
0006935
0007565
0001701
0007612
0008285
0060674
0051091
2000144
0043065
0045787
0008284
0045944
0061614
0006357
0051591
0051412
0034097
0009629
0042542
0009612
0032570
0009615
0006366
0007296
0005829
0043005
0005654
0005634
0042734
0003677
0000977
0006355
0043231
0042493
0014070
0000982
0001077
0043565

KEGG ID hsa:8061
mmu:14283
rno:25445

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 19 4.33 cM

OMIM ID 136515

Rat chromosome position 1q43

Hugo ID 13718
HGNC:13718

Human chromosome position 11q13.1
11q13

Swiss-Prot Accession E9PPX2
P15407
E9PKL5
A0A0S2Z595
P15407.1
P48755
Q3UMK5
P48755.2
P10158
P10158.1
B4DR11
Q6FG51
O35285
Q4V8K7

PIR ID S15750
A27722

GenBank ID NC_000011
NR_125339
NM_001300857
NP_001287786
NM_001300856
NP_001287785
NM_001300844
NP_001287773
NM_001300855
NP_001287784
NM_005438
NP_005429
AJ297411
CAC50237
AJ297412
AJ297413
AP006287
CH471076
EAW74469
D14493
BAA03386
D16365
BAA03867
KT583991
AA120824
AK222902
BAD96622
AK293297
BAG56818
AK299050
BAG61123
AK313718
BAG36461
BC016648
AAH16648
BM764259
BM846271
BP222547
BQ937004
CB123614
CR542257
CAG47053
CR542278
CAG47074
KU178407
ALQ33865
KU178408
ALQ33866
S68214
X16707
CAA34679
P15407
NC_000085
NM_010235
NP_034365
AC122861
AF017128
AAB71369
CH466612
EDL33130
AK144785
BAE26065
AK144839
BAE26093
AK145035
BAE26198
BC052917
AAH52917
U34245
AAC52888
P48755
NC_005100
NM_012953
NP_037085
AC_000069
AAHX01009278
AC109096
CH473953
EDM12489
U24154
AAA82045
BC060582
BC097342
AAH97342
M19651
AAA41171
P10158
NC_018922
AMYH02024966
DQ891054
ABM81980
DQ892703
ABM83629
DQ893332
ABM84258
DQ894233
ABM85159
DQ896648
ABM87647
EU176469
ABW03920
AC_000041
AAHY01141362
XM_005274311
XP_005274368
AC_000143
ABBA01024097

Swiss-Prot ID FOSL1_HUMAN
FOSL1_MOUSE
FOSL1_RAT

Cell Localization Nucleus

Ensembl ID ENSG00000175592
ENSP00000436276.1
ENST00000531493.5
ENSP00000431594.1
ENST00000532401.1
ENSP00000393302.2
ENST00000448083.6
ENSP00000310170.2
ENST00000312562.6
ENSMUSG00000024912
ENSMUSP00000025850.5
ENSMUST00000025850.6
ENSRNOG00000020552
ENSRNOP00000027891.1
ENSRNOT00000027891.2
ENSP00000436276
ENST00000531493
ENSP00000431594
ENST00000532401
ENSP00000393302
ENST00000448083
ENSP00000310170
ENST00000312562
ENSMUSP00000025850
ENSMUST00000025850
ENSRNOP00000027891
ENSRNOT00000027891

MGI ID MGI:107179

RGD ID 2627

Unigene ID Hs.283565
Mm.6215
Rn.11306

Homologene ID 3967

Shape O-vertex