URN | urn:agi-llid:6775 |
---|---|
Total Entities | 0 |
Connectivity | 1224 |
Name | STAT4 |
Description | signal transducer and activator of transcription 4 |
Notes | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
Primary Cell Localization | Nucleus |
Class | Transcription factor |
Pathway | CD8+ T-Cell Activation |
---|---|
Th1-Cell Differentiation | |
Th1-Cells Activation and Proliferation in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Proteins Involved in Myocarditis | |
Atopic Dermatitis | |
T-Cells Differentiation Block in Psoriasis | |
Th1-Cell Function in Systemic Lupus Erythematosus | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy | |
CD4+T-Cell Response in Celiac Disease | |
Th1-Cell Activation in Crohn's Disease | |
Proteins Involved in Ulcerative Colitis | |
Proteins Involved in Rheumatoid Arthritis | |
IL12 Antitumor Effect is Blocked in Cancer | |
IL27R -> STAT Signaling | |
IL12R -> STAT Signaling | |
UrokinaseR -> STAT Signaling | |
NOTCH -> Expression Targets in Thymus | |
Elevated Receptors -> Expression Targets in Testis | |
PPAR Psoriasis | |
Model of PPARG signaling in psoriasis | |
New Pathway (3) | |
Figure 3_Mixed network of dexamethasone targets | |
Figure 3_Mixed network of dexamethasone targets | |
1_Differentiation of psoriatic T cells | |
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease | |
4_1_Polymorphisms associated with inflammatory bowel diseases | |
Differentiation of psoriatic T cells |
Group | Genes with Mutations Associated with Psoriasis |
---|---|
Genes Associated with Systemic Lupus Erythematosus | |
Genes with Mutations Assosiated with Rheumatoid Arthritis |
MedScan ID | 6775 |
---|
LocusLink ID | 6775 |
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20849 | |
367264 |
Alias | signal transducer and activator of transcription 4 |
---|---|
transcription factor STAT4 | |
STAT4 | |
signal transducers and activators of transcription 4 | |
OTTHUMP00000163553 | |
SLEB11 | |
STAT4 transcription factor | |
STA4_MOUSE | |
signal transducer and activator of transcription 4 variant 3 | |
Systemic lupus erythematosus, susceptibility to, 11 | |
signal transducer and activator of transcription IV |
GO ID | 0001228 |
---|---|
0003700 | |
0000981 | |
0000978 | |
0007259 | |
0019221 | |
0006952 | |
0035722 | |
0038114 | |
0038155 | |
0070757 | |
0045944 | |
0042127 | |
0043434 | |
0005829 | |
0005654 | |
0005634 | |
0003677 | |
0043565 | |
0008283 | |
0071310 | |
0010628 | |
0006468 | |
0006355 | |
0007165 | |
0005737 | |
0071345 | |
0071407 | |
0061326 | |
0006351 | |
0000977 | |
0004871 | |
0000979 | |
0042803 | |
0000983 | |
0005164 | |
0035458 | |
0060333 | |
0046725 | |
0043124 | |
0016525 | |
0001937 | |
0033209 | |
0000790 | |
0005730 | |
0048471 | |
0005509 | |
0003690 | |
0019899 | |
0031663 | |
0043330 | |
0009617 | |
0032496 |
KEGG ID | hsa:6775 |
---|---|
mmu:20849 | |
rno:367264 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 1 26.67 cM |
---|---|
1 25.9 cM |
OMIM ID | 600558 |
---|---|
612253 | |
180300 | |
152700 |
Rat chromosome position | 9q22 |
---|
Hugo ID | 11365 |
---|---|
HGNC:11365 |
Human chromosome position | 2q32.2-q32.3 |
---|
Swiss-Prot Accession | Q14765 |
---|---|
Q14765.1 | |
P42228 | |
Q3V157 | |
P42228.1 | |
Q66HB2 | |
Q96NZ6 | |
Q53RU2 | |
Q53S87 | |
Q59GR6 | |
Q3U098 | |
Q4G0C1 | |
Q8C2A4 | |
O70428 |
PIR ID | A56047 |
---|
Swiss-Prot ID | STAT4_HUMAN |
---|---|
STAT4_MOUSE | |
Q66HB2_RAT | |
Q3V157_MOUSE |
Cell Localization | Cytoplasm |
---|---|
Nucleus |
Ensembl ID | ENSG00000138378 |
---|---|
ENSP00000351255.4 | |
ENST00000358470.8 | |
ENSP00000376134.2 | |
ENST00000392320.7 | |
ENSMUSG00000062939 | |
ENSMUSP00000130713.1 | |
ENSMUST00000168302.7 | |
ENSMUSP00000027277.5 | |
ENSMUST00000027277.6 | |
ENSRNOG00000014079 | |
ENSRNOP00000020032.5 | |
ENSRNOT00000020032.6 | |
ENST00000392320.6 | |
ENSP00000351255 | |
ENST00000358470 | |
ENSP00000376134 | |
ENST00000392320 | |
ENSMUSP00000027277 | |
ENSMUST00000027277 | |
ENSRNOP00000020032 | |
ENSRNOT00000020032 | |
ENSMUSP00000130713 | |
ENSMUST00000168302 | |
ENSRNOG00000050942 |
MGI ID | MGI:103062 |
---|---|
103062 |
RGD ID | 1305747 |
---|
Unigene ID | Hs.80642 |
---|---|
Mm.1550 | |
Rn.137580 | |
Hs.735572 |
Homologene ID | 20679 |
---|
Shape | O-vertex |
---|
IPI ID | IPI00114970 |
---|---|
IPI00000106 | |
IPI00471606 | |
IPI00649102 |