Protein CLEC7A

URN urn:agi-llid:64581
Total Entities 0
Connectivity 1145
Name CLEC7A
Description C-type lectin domain family 7 member A
Notes This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Mannose Receptor Signaling
Dectin-1 (CLEC7A) Signaling
Antigen-Presenting Cell Role in Asthma
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
1_Th2 cell response in asthma
4_2_Genes with mutations currently associated with ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases

MedScan ID 64581

LocusLink ID 64581
56644
502902

Alias dendritic cell-associated C-type lectin 1
Dendritic cell-associated C-type lectin-1 beta
beta-glucan receptors
C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12
UNQ539/PRO1082
SCARE2
Clec7b
DECTIN-1 receptor
transmembrane protein dectin I
lectin-like receptor 1
DC-associated C-type lectin 1
CD369
RGD1565140
c-type lectin domain family 7, member a
DECTIN I
lectin-like receptor I
DECTIN-1 receptors
Clecsf12
clec7a
hDectin I
DECTIN1
beta-glucan receptor
hDectin-1
C-type lectin, superfamily member 12
transmembrane protein dectin-1
C-type lectin, superfamily member XII
CANDF4
Beta-glucan receptor isoform B
C-type lectin domain containing 7A
Lectin-like receptor 1B
beta-gr
BGR
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
C-type lectin superfamily member 12
dectin-1
dendritic cell-associated C-type lectin-1
C-type lectin domain family 7 member A

GO ID 0001872
0042287
0030246
0046872
0008329
0042110
0009756
0008037
0071226
0042832
0016046
0032491
0006954
0045087
0002221
0006910
1903431
0030335
0008284
0043280
1900017
0010628
0045078
0032731
0045082
0045084
0045086
0045410
0045416
0051712
0051251
0071639
0045429
0050766
0031334
0060267
0032930
0042535
0090303
0009986
0005737
0016021
0043231
0005654
0005886
0002366
0002223
0001874
0001846
0030247
0002752
0001879
0002376
0006911
0032760
0002238
0001878
0016337
0009897
0016020

KEGG ID hsa:64581

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6

OMIM ID 606264
614079
613108

Rat chromosome position 4q42

Hugo ID 14558
HGNC:14558

Human chromosome position 12p13.2

Swiss-Prot Accession Q68D78
Q9BXN2
A0A024RAN9
A0A0S2Z5Q1
Q9BXN2.1
V9GXI5
Q6QLQ4.3
B2RYG9
B5BUZ1
B5BUZ2
B2R861
B7Z494
B7Z5A9
B7Z5B9
Q6IPS7
Q96D32
Q96DR9
Q96LD3
Q96PA4
Q96PA5
Q96PA6
Q96PA7
Q96PA8
Q9H1K3
Q6QLQ4

GenBank ID NC_000012
NR_125336
NM_197947
NP_922938
NM_197950
NP_922941
NM_197949
NP_922940
NM_022570
NP_072092
NM_197948
NP_922939
XM_017019822
XP_016875311
XM_017019823
XP_016875312
XM_006719135
XP_006719198
XM_024449133
XP_024304901
XM_024449132
XP_024304900
NM_197954
NP_922945
NG_016291
AC024224
CH471094
EAW96144
EAW96145
EAW96146
EAW96147
EAW96148
EAW96149
EAW96150
EAW96151
EAW96152
EAW96153
EAW96154
EAW96155
CQ779237
CAF63003
CQ779239
CAF63006
AA361063
AF313468
AAK37473
AF313469
AAK37474
AF400595
AAL11711
AF400596
AAL11712
AF400597
AAL11713
AF400598
AAL11714
AF400599
AAL11715
AF400600
AAL11716
AF400601
AAL11717
AF400602
AAL11718
AJ312372
CAC43846
AJ312373
CAC43847
AK294111
BAH11674
AK295108
BAH11976
AK297028
BAH12480
AK298679
BAH12845
AK298724
BAH12855
AK313247
BAG36058
AY009090
AAG33923
AY026769
AAK20114
AY026770
AAK20115
AY026771
AAK20116
AY358685
AAQ89048
AY359002
AAQ89361
BC013385
AAH13385
BC071746
AAH71746
BC093829
AAH93829
BC093831
AAH93831
CR749536
CAH18342
DA193873
KU178745
ALQ34203
KU178746
ALQ34204
LC369590
BBC70867
LC369591
BBC70868
Q9BXN2
NC_000072
NM_001309637
NP_001296566
NR_132130
NM_020008
AC138620
CH466523
EDK99926
EDK99927
CQ779241
CAF63010
AA240643
AF262985
AAF72710
AY534909
AAS37670
BC027742
AAH27742
BY547544
BY750022
Q6QLQ4
NC_005103
XM_006237100
XP_006237162
NM_001173386
NP_001166857
XR_001837491
AC_000072
AABR07073062
AAHX01033063
CH473964
EDM01739
EDM01740
AB455106
BAG69160
AB455107
BAG69161
BC166774
AAI66774
GU357485
ADK94895
XM_005253467
XP_005253524
NC_018923
AMYH02026022
HQ447540
ADQ32026
NP_064392
AC_000028
AAHY01057557
AAHY01057558
AAHY01057559
XM_006719136
XP_006719199
XM_005253468
XP_005253525
AC_000144
ABBA01067796

Swiss-Prot ID CLC7A_HUMAN

Cell Localization Cell membrane
Cytoplasm

Ensembl ID ENSG00000172243
ENSP00000266456.6
ENST00000353231.9
ENSP00000302569.8
ENST00000304084.12
ENSP00000431461.1
ENST00000533022.5
ENSP00000298523.5
ENST00000298523.9
ENSP00000379743.2
ENST00000396484.6
ENSP00000312089.4
ENST00000310002.4
ENSP00000434392.1
ENST00000531192.5
ENSMUSG00000079293
ENSMUSP00000139167.1
ENSMUST00000184581.2
ENSMUST00000195589.5
ENSRNOG00000054251
ENSRNOP00000073639.1
ENSRNOT00000091552.1
ENSRNOP00000069723.1
ENSRNOT00000077793.1
ENSP00000266456
ENST00000353231
ENSP00000302569
ENST00000304084
ENSP00000431461
ENST00000533022
ENSP00000298523
ENST00000298523
ENSP00000379743
ENST00000396484
ENSP00000312089
ENST00000310002
ENSP00000432876
ENST00000529761
ENSP00000434392
ENST00000531192
ENSMUSP00000141234
ENSMUST00000195589
ENSRNOP00000073639
ENSRNOT00000091552
ENSRNOP00000069723
ENSRNOT00000077793
ENSRNOG00000033879
ENSRNOP00000056630
ENSRNOT00000059885

MGI ID MGI:1861431

RGD ID 1565140

Unigene ID Hs.143929
Mm.239516
Rn.15743

Homologene ID 49606

Shape Stick-vertex