Pathway
|
Alzheimer's Disease
|
|
Skin Aging
|
|
Apoptosis of Cochlear Hair Cells (Noise-Induced, Mouse Model)
|
|
Melatonin Effects on Circadian Cycle
|
|
mTOR Signaling
|
|
mTOR Signaling Hyperfunction
|
|
SIRT2 Signaling in Aging
|
|
Fatty Acids Cause Oxidative Stress and Mitochondria Decline in Aging
|
|
Insulin Signaling
|
|
Prolactin Production
|
|
Estrogens in Prolactin Production
|
|
Toll-like Receptors Act through MYD88-TIRAP Signaling
|
|
TLR4 Signaling in Leukocytes
|
|
T-Cell Maturation (Hypothesis)
|
|
T-Cell Positive Selection and Neglect Induced Death
|
|
T-Cell Central Tolerance
|
|
T-Cell Cytotoxic Mediated Cell Death
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Necrosis
|
|
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
|
|
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Eosinophil Activation
|
|
Histidine-Rich Glycoprotein (HRG)
|
|
Melatonin in Cell Survival and Antioxidant Response
|
|
Nuclear Lamina Cleavage
|
|
Apoptosis
|
|
G1/S Damage Checkpoint
|
|
Cell Cycle Overiew
|
|
Tight Junction Assembly (Occludin)
|
|
SCF/FBXO11 Complex
|
|
CUL4/CRL (SCF4) Complex
|
|
SCF/BTRC Complex
|
|
SCF/SKP2 Complex
|
|
SCF/FBXO7 Complex
|
|
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
|
|
Low-Density Lipoproteins and Chemokines in Atherosclerosis
|
|
Endothelial Cell Dysfunction in Pulmonary Hypertension
|
|
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
|
|
BMP2 and Canonical WNT Signaling in Pulmonary Artery Endothelial Cells
|
|
Reperfusion Injury in Myocardial ischemia
|
|
Oxygen Shortage in Myocardial Ischemia
|
|
Myocardial Infarction
|
|
Preconditioning Ischemia
|
|
Apoptosis of Myocyte
|
|
NO Synthesis in Early Vasospasm
|
|
Hemoglobin Reduction and Leukocyte Adhesion Initiate Vasospasm
|
|
Hair Follicle Keratinocyte Apoptosis
|
|
Harlequin Ichthyosis
|
|
Melanoma
|
|
Apoptosis Block in Melanoma Cell
|
|
MITF as a Regulator of Melanoma Cell Development
|
|
IL17 Signaling in Psoriasis
|
|
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
|
|
Melanocyte Role in Skin Aging
|
|
POMC Activation in Keratinocytes
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Oxidative Stress in Vitiligo
|
|
Vitiligo
|
|
Apoptosis of Melanocyte in Vitiligo
|
|
Toll-like Receptors in beta-Cell
|
|
Macrophage Function in Diabetes Mellitus Type 1
|
|
beta-Cell Death in Diabetes Mellitus Type 2
|
|
Podocyte Dysfunction in Diabetic Nephropathy
|
|
AGE Related Insulin Resistance in Skeletal Muscles
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Recovery in Diabetes Mellitus
|
|
beta-Cell Destruction in Diabetes Mellitus Type 1
|
|
Nitric Oxide Effects on beta-Cell
|
|
Hyperglycemia and Hyperlipidemia Trigger beta-Cell Apoptosis
|
|
beta-Cell Function Inhibition by Ciclosporine and Tacrolimus (Rodent Model)
|
|
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
|
|
Immune Sustem Activation in Hashimoto's Thyroiditis
|
|
Hashimoto's Thyroiditis
|
|
Apoptosis of Thyroid Cell in Hashimoto's Thyroiditis
|
|
Hashimoto's Thyroiditis Triggers
|
|
Myocyte Dysfunction in Hypoparathyroidism
|
|
Thymic Follicular Hyperplasia
|
|
Fatty Acids in Hypertension and Atherosclerosis Development
|
|
Cetuximab Resistance in Colorectal Cancer
|
|
Metastatic Colorectal Cancer
|
|
EGFR Nuclear Signaling in Colorectal Cancer
|
|
Th17-Cell Activation in Crohn's Disease
|
|
Macrophage Dysfunction
|
|
Genes with Susceptibility for Crohn's Disease and Ulcerative Colitis
|
|
Apoptosis through VacA in Helicobacter Pylori Infection
|
|
CagA Phosphorylation Dependent Signaling
|
|
Peutz-Jeghers Syndrome
|
|
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
Apoptosis Block in Acute Myeloid Leukemia Cell
|
|
Acute Myeloid Leukemia
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Diffuse Large-B-Cell Lymphoma ABC Subtype
|
|
Lymphoma, GCB Subtype
|
|
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
|
|
Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
Mantle Cell Lymphoma
|
|
Apoptosis of Mantle Cell Deregulation
|
|
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
|
|
Hedgehog Signaling in Mantle Cell Lymphoma
|
|
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
|
|
Splenic Marginal Zone Lymphoma
|
|
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
|
|
Osteoclast Activation in Multiple Myeloma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
SERPINA1 Associated Pulmonary Emphysema
|
|
SERPINA1 Associated Liver Damage
|
|
Hepatocellular Carcinoma
|
|
TP53 Signaling in Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Pancreatic Ductal Carcinoma
|
|
Growth Factor Signaling in Pancreatic Neoplasms
|
|
TP53 Signaling in Pancreatic Neoplasms
|
|
Pancreatic Neuroendocrine Tumors
|
|
STK11 Signaling in Pancreatic Neoplasms
|
|
TGFBR Signaling in Pancreatic Neoplasms
|
|
Eosinophil Survival in Asthma
|
|
TSLP Signaling in Bronchial Epithelial Cell in Asthma
|
|
Basophil Activation in Asthma
|
|
Osteoclast Activation in Gout
|
|
Apoptosis of Chondrocyte
|
|
Osteoclast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Apoptosis Block in Synovial Fibroblast
|
|
FAS Mediated Apoptosis in Systemic Scleroderma
|
|
Apoptosis Block in Infected Cells
|
|
CD4+ T-Cell Death in HIV
|
|
TNF Receptor Associated Periodic Syndrome
|
|
Li-Fraumeni Syndrome
|
|
Hereditary Breast and Ovarian Cancer Syndrome
|
|
Cowden Syndrome
|
|
PPARGC1A Repression in Huntington Disease
|
|
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
|
|
NF-kB Signaling Activation in Huntington Disease
|
|
Huntingtin Gene Mutation in Striatal Neuron
|
|
ER Stress in Huntington Disease
|
|
CA4 Induces Apoptosis of Choriocapillaris Endothelial Cells in RP
|
|
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
|
|
Drugs Targets in Autistic Disoreder (Hypothesis)
|
|
Werner Syndrome (Adult Progeria)
|
|
IL6 Promotes Inflammation in Muscular Dystrophies
|
|
Ca2+ Overload in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
|
|
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
|
|
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
|
|
Glioblastoma, Primary
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Ependymoma
|
|
Medulloblastoma
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
ALK Associated Neuroblastoma
|
|
Sonic Hedgehog Signaling in Neuroblastoma
|
|
non-Hereditary Genetic Rearrangements in Neuroblastoma
|
|
SOD1 Mutation
|
|
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
|
|
MIR155 Role in Th17-Cell in Multiple Sclerosis
|
|
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Breast Cancer
|
|
ESR1 Signaling in Breast Cancer
|
|
Endometrial Cancer
|
|
Endometrioid Endometrial Cancer
|
|
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
|
|
Dioxin Role in Endometriosis
|
|
Progesterone Resistance in Endometriosis
|
|
Retinoic Acid Role in Endometriosis
|
|
Endometrioid Ovarian Carcinoma
|
|
Clear Cell Ovarian Carcinoma
|
|
High-Grade Serous Ovarian Carcinoma
|
|
Low-Grade Serous Ovarian Carcinoma
|
|
Ovarian Cancer
|
|
Mucinous Ovarian Carcinoma
|
|
FOXL2 Mutation in Ovarian Dysgenesis
|
|
MIF Role in Cholesteatoma
|
|
IL6/JAK/STAT3 Signaling in Cholesteatoma
|
|
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV E1 and E2 Expression in Early Phase of Cancer
|
|
HPV E6 and E7 Induced Block of Apoptosis in Keratinocytes
|
|
HPV Infection and Cancer
|
|
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
Androgen Receptor/Akt Signaling
|
|
Fatty Acid Synthase (FASN) Signaling
|
|
Androgen Receptor/FKBP5 Signaling
|
|
Androgen Receptor/NKX3-1 Signaling
|
|
Kruppel-like Factor 6 Signaling in Prostate Cancer
|
|
Prostate Cancer
|
|
RNase L Signaling in Prostate Cancer
|
|
Androgen Receptor/Protein Kinase C-delta Signaling
|
|
Androgen Receptor/SGK1 Signaling
|
|
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
|
|
TLR3 Role in Retinal Pigment Epithelial Cell
|
|
ER Stress in Macular Degeneration
|
|
VEGFA in Neovascular Glaucoma
|
|
OPTN Effects on NF-kB Signaling in Glaucoma
|
|
MYOC Associated Glaucoma
|
|
Glutamate Mediated Excitotoxicity in Glaucoma
|
|
OPTN Associated Glaucoma
|
|
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
|
|
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
|
|
Alveolar Epithelial Cell Apoptosis in COPD
|
|
Alveolar Epithelial Cell Autophagy in COPD
|
|
Podocyte Dysfunction in Glomerulonephritis
|
|
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
|
|
GLP1R -> ARRB1 Signaling
|
|
AGTR1 -> ARRB1/ARRB2 Signaling
|
|
Tamoxifen Induced Endometrial Cancer
|
|
Dexamethasone Induced Osteoporosis
|
|
Doxorubicin Induced Cardiotoxicity
|
|
TAM Receptor Signaling Activation in Cancer
|
|
PI3K/AKT/MTOR Signaling Activation in Cancer
|
|
DREAM Complex and FOXM1/MYBL2 Promote Cell Cycle Progression in Cancer
|
|
Hedgehog Signaling Activation in Cancer
|
|
NFKB Canonical Signaling Activation in Cancer
|
|
RAS/RAF/MAPK Signaling Activation in Cancer
|
|
NFKB Non-Canonical Signaling Activation in Cancer
|
|
DNA Damage Checkpoint Impairment in Cancer
|
|
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
|
|
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
|
|
Hedgehog Signaling Activation by Blocking of Tumor Suppressors
|
|
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
|
|
NFKB Signaling Activation by Blocking of Tumor Suppressors
|
|
Apoptosis Block by Inhibitor of Apoptosis Proteins (IAPs) in Cancer
|
|
Suppression of Caspase Activity in Cancer
|
|
Apoptosis Block by Death Receptor Signaling in Cancer
|
|
Apoptosis Evasion in Cancer: Overview
|
|
Hypoxia-Induced Cell Death Evasion in Cancer
|
|
Apoptosis Block by BCL2 Family Proteins in Cancer
|
|
TERT Activation in Cancer
|
|
Telomeric Proteins/NFKB Positive Feedback Interplay in Cancer
|
|
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
|
|
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
|
|
Integrins in Cancer Cell Motility, Invasion and Survival
|
|
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
|
|
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
|
|
Respiratory Chain Impairment in Cancer
|
|
Skeletal Muscle Wasting in Cancer Cachexia
|
|
Glutamine in Cancer Metabolism
|
|
Mutations in Krebs Cycle Enzymes in Cancer
|
|
Effector T-cell Inactivation in Cancer Immune Escape
|
|
TNF-alpha/TNFRSF1A Signaling
|
|
FOXO1 Signaling
|
|
Ras Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
mTOR Signaling
|
|
KRAS Signaling
|
|
VEGF Signaling
|
|
EGFR Signaling
|
|
HRAS Signaling
|
|
NF-kB Canonical Signaling
|
|
ROS in Neutrophil Mediated Cell Damage
|
|
ER Stress (Unfolded Protein Response)
|
|
Glutamate Mediated Neurotoxicity
|
|
Mitochondrial Damage Induced by Hypoxia
|
|
Ca2+ Cytosolic Overload
|
|
ace2
|
|
New Pathway (2)
|
|
sialic
|
|
Histones Modifications Sites in Cell Vitality
|
|
H3 Arginin Modification Sites
|
|
H2A Modification Sites
|
|
H4 Modification Sites
|
|
Overview. Diseases of the digestive system (chapter 10)
|
|
Overview. Diseases of the eye (chapter 6)
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
3_X-linked ichthyosis overview
|
|
2_Chondrocyte death in osteoarthritis
|
|
2_Podocyte dysfunction in glomerulonephritis
|
|
2_Progesterone resistance stimulates endometriotic cell survival
|
|
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
|
|
2_MYOC-associated glaucoma
|
|
2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
|
|
3_Endoplasmic reticulum stress in age-related macular degeneration
|
|
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
|
|
1_Low-density lipoprotein internalization and the accumulation of lipids in atherosclerosis
|
|
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
|
|
2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
|
|
3_Autophagy dysfunction in Crohn's disease
|
|
1_Intestine epithelial cell dysfunction in ulcerative colitis
|
|
2_Lipotoxicity in NAFLD
|
|
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
|
|
2_Human papilloma virus E1 and E2 proteins in virus replication
|
|
3_Human papilloma virus E4 and E5 proteins in viral reproduction
|
|
4_Human papilloma virus E6 and E7 proteins promote epithelial cell survival
|
|
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
|
|
2_HIV - induced depletion of CD4+ T-cells
|
|
3_2_HIV postintegration latency
|
|
2_Hyperglycemia and hyperlipidemia trigger beta-cell apoptosis
|
|
1_SERPINA1-associated pulmonary emphysema
|
|
2_SERPINA1-associated liver damage
|
|
3_Islet beta-cell destruction in T1D
|
|
2_Neuron and Schwann cell death
|
|
1_Glutamate and calcium excitotoxicity of motor neurons in ALS
|
|
2_Mutations in SOD1 and associated proteins cause motor neuron death in familial ALS
|
|
DIPG non histone mutations
|
|
New Pathway (1)
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|