Protein IL6

URN urn:agi-llid:3569
Total Entities 0
Connectivity 23636
Name IL6
Description interleukin 6
Notes This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway Alzheimer's Disease
Androgen Deficiency in Male Obesity
Cortisol in Resolving Inflammation
Toll-like Receptors Act through MYD88-TIRAP Signaling
TLR4 Signaling in Leukocytes
Dectin-2 (CLEC6A)/Mincle (CLEC4E)/BDCA2 (CLEC4C) Signaling
T-Cell Maturation (Hypothesis)
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
Annexins in Inflammation Resolution
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage Related Iron Uptake and Release
Macrophage M1 Lineage
AHR Signaling in M1 Macrophages Function
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
ADRA1A -> IL6 Production
BDKRB1/2 -> Interleukins Production
CNR1/2 -> IL1B/2/4/6/10 Production
PTGIR -> IL6 Production
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR7 -> IL6 Production
TACR1 -> TNF/IL6/IL8 Production
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
Leptin -> CD25/IL6/IL10 Production
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Hair Follicle Keratinocyte Apoptosis
Androgens Promote Scalp Dermal Papilla Regression
Proteins Involved in Melanoma
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
Proteins Involved in Photoaging
Dendritic Cell Activation in Systemic Lupus Erythematosis
Proteins Involved in Systemic Lupus Erythematosus
Th17-Cell Function in Systemic Lupus Erythematosus
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Proteins Involved in Vitiligo
Proteins with Altered Expression in Vitiligo
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Neuropathy
Microangiopathy in Diabetic Neuropathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Adipose Tissue Inflammation Provokes Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
Thyroid Hormones in Adipose Tissue Metabolism
Proteins Involved in Graves Disease
Graves Ophthalmopathy
Thymic Follicular Hyperplasia
Proteins Involved in Myasthenia Gravis
Fatty Acids in Hypertension and Atherosclerosis Development
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Proteins Involved in Celiac Disease
CD4+T-Cell Response in Celiac Disease
Proteins with Altered Expression in Celiac Disease
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
Crohn's Disease
B-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Proteins Involved in Hodgkin Lymphoma
Mantle Cell Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in Multiple Myeloma
NOTCH Signaling in Multiple Myeloma
TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
Antiphospholipid Antibodies and Endothelial Cell Interaction
Proteins Involved in Thrombophilia
SERPINA1 Associated Liver Damage
TRPM7/8 in Pancreatic Adenocarcinoma
Eosinophil Survival in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Basophil Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Airway Epithelial Cell Dysfunction
Proteins Involved in Gout
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
Proteins Involved in Osteoarthritis
Proteins Involved in Polycystic Ovary Syndrome
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
Proteins with Altered Expression in Systemic Scleroderma
Proteins Involved in HIV Type 1 Infection
Th17-Cell Numbers Reduction in HIV
CD4+ T-Cell Function Decline in HIV
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
Estrogen Effects on Pregnancy Gingivitis
Proteins Involved in Periodontitis
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
NF-kB Signaling Activation in Huntington Disease
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
Proteins Involved in Autistic Disorder
Drugs Targets in Autistic Disoreder (Hypothesis)
Proteins Involved in Autistic Disorder and Aggression
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
IL6 Overexpression After Contraction in Skeletal Muscles in Muscular Dystrophies
Proteins Involved in Osteoporosis
Bone Loss in Osteoporosis
Proteins with Altered Expression in Psoriatic Arthritis
Proteins with Altered Expression in Rheumatoid Arthritis
Microglia Activation in Alzheimer's Disease
Proteins Involved in Alzheimer's Disease
Proteins Involved in Epilepsy
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
HMGB1 and IL1B in Neuroinflammation
ADK Expression Downregulation after Acute Seizures
Proteins Involved in Glioblastoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Glioma Stem Cell Program Activation
Proteins Involved in Medulloblastoma
Proteins Involved in Migraine
Proteins Involved in Neuroblastoma
Microglia Activation in Parkinson's Disease
Proteins with Altered Expression in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Proteins with Altered Expression in Amyotrophic Lateral Sclerosis
Proteins Involved in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
Neuroinflammation in Amyotrophic Lateral Sclerosis
MBP/MOG/PLP in Immune System Activation
Proteins Involved in Multiple Sclerosis
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Proteins Involved in Sleep Disorders
Proteins Involved in Vascular Dementia
Proteins Involved in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Cholesteatoma
IL6/JAK/STAT3 Signaling in Cholesteatoma
Cholesteatoma
Proteins Involved in HPV Infection
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Androgen Receptor/FKBP5 Signaling
Prostate Cancer
Proteins Involved in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
ER Stress in Macular Degeneration
Proteins Involved in Noise-Induced Hearing Loss
Cochlear Inflammation (Noise-Induced)
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Proteins Involved in Pulmonary Emphysema
Proteins with Altered Expression in Cystic Fibrosis
Proteins Involved in Erectile Dysfunction
Proteins Involved in Glomerulonephritis
Proteins with Altered Expression in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Proteins with Altered Expression in Pyelonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
HMGB1 Expression Targets
TTR Expression Targets
S100B Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> STAT Expression Targets
AREG -> AP-1 Expression Targets
AREG -> FOXO3A Expression Target
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
BMP2/BMPR2 Expression Targets
BMP7/BMPR2/ACVR2 Expression Targets
Elevated Receptors -> Expression Targets in Joint
Elevated Receptors -> Expression Targets in Bone and Joint
CD2 Expression Targets
CD19 Expression Targets
CD19/CR2 Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD8 -> NF-kB Expression Targets
CD80 -> AP-1 Expression Targets
CD80 -> STAT Expression Targets
CD80 -> NF-kB Expression Targets
CD80 -> ATF/CREB/CREBBP Expression Targets
CD86 -> NFATC Expression Targets
CD86 -> ATF/CREB/CREBBP Expression Targets
CD86 -> STAT Expression Targets
CD86 -> NF-kB Expression Targets
CTF1 Expression Targets
CXCL2 Expression Targets
CXCL5 Expression Targets
CXCL12 Expression Targets
CCL3L1 Expression Target
CCL7 Expression Target
CCL15 Expression Targets
IL8 Expression Targets
CSF3 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF18 -> STAT Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
GCG Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
Elevated Receptors -> Expression Targets in Liver
Elevated Receptors -> Expression Targets in Mouth
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
TAM Receptor Signaling Activation in Cancer
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
Proteins with Altered Expression in Tumor-Promoting Inflammation
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
VEGFA Dependent Angiogenesis in Cancer
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Proteins with Altered Expression in Cancer Immune Escape
IGF2 -> STAT Expression Targets
INHBA/ACVR2/BMPR Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
Fibrinogen Expression Targets
IFNG/IFNR Expression Targets
IL6R -> CEBP/ELK/SRF Signaling
IL6R -> STAT Signaling
IL6ST -> STAT5B Signaling
IL7 Expression Targets
IL13 Expression Targets
IL21 Expression Targets
IL15 Expression Targets
IL16 -> AP-1 Expression Targets
IL3 Expression Targets
IL16 -> STAT Expression Targets
IL6 Expression Targets
IL5 Expression Targets
IL11 Expression Targets
IL16-> ATF/CREB/CREBBP Expression Target
IL2 Expression Targets
IL16 -> NF-kB Expression Targets
PTPRC -> BCL6 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
S1P Expression Targets
PGE1 Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
TGF-beta Receptors Family -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymph Node
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Cell Adhesion Receptors -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Receptor Tyrosine Kinase Family -> Expression Targets in Lymphoid System and Blood
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
C5AR1 -> Expression Targets in Lymphoid System and Blood
IgE Receptors -> Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Spleen
Elevated Receptors -> Expression Targets in Thymus
CNR1-> Expression Targets in Nerve Tissue
GPCRs -> Expression Targets in Brain
Elevated Receptors -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
DLL4 Expression Targets
ADAM17 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
OSM/OSMR Expression Targets
OSM/IL6ST/LIFR Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
GNRH1 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
SST Expression Targets
IFNA1/Gq Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
CSF1 -> STAT Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
Collagen -> NF-kB Expression Targets
PAF Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
MSTN/ACVR2/BMPR Expression Targets
Elevated Receptors -> Expression Targets in Lung
Elevated Receptors -> Expression Targets in Respiratory System
Estrogens/ESR1 Genomic Canonical Signaling
FOXO1 Signaling
MERTK Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFB2-TGFBR1 Expression Targets
TGFB3-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> STAT Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNF -> CREB Expression Targets
TNF -> STAT Expression Targets
TLR3 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
ROS in Triggering Vascular Inflammation
WNT5A Expression Targets
pathway 3
PPAR Psoriasis
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative regulators
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
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Neighbors of macrophage differentiation
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Neighbors of interstitial fibrosis
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Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
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Neighbors of cardiovascular disease
Neighbors of stroke
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Neighbors of neoplasm
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Neighbors of neointima
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Neighbors of coronary artery disease
Neighbors of rupture
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Neighbors of prostate cancer
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Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
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Neighbors of fibroblast
Neighbors of airway epithelial cell
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Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of aortic smooth muscle cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of carotid artery
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of lymphatic system
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of allantois
Neighbors of alveolus
Neighbors of coronary artery
Neighbors of left ventricle
Neighbors of uterine cervix
Neighbors of omentum
Neighbors of vein
Neighbors of arteriole
Neighbors of villus
Neighbors of bronchus
Neighbors of glands
Neighbors of nose
Neighbors of eye
Neighbors of cornea
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of lymph node of mesentery
Neighbors of mammary gland
Neighbors of vagina
Neighbors of ankle joint
Neighbors of vitreous body
Neighbors of thymus gland
Neighbors of cerebral cortex
Neighbors of brain blood vessel
Neighbors of myelin sheath
Neighbors of bladder
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Neighbors of nervous system
Neighbors of blastocyst
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Neighbors of periodontal ligament
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Neighbors of corpus luteum of ovary
Neighbors of sympathetic nervous system
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Neighbors of ileum
Neighbors of endocrine system
Neighbors of lower extremity
Neighbors of small intestine
Neighbors of aggregated lymphoid follicle of small intestine
Neighbors of globus pallidus
Neighbors of amniotic cavity
Neighbors of lumbar spine
Neighbors of knee joint
Neighbors of hip region
Neighbors of reproductive system
Neighbors of pleura
Neighbors of left atrium
Neighbors of hypothalamus
Neighbors of artery wall
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
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Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
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Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of endothelin
Neighbors of NOS
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of alpha2 adrenoceptor
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of relaxin
Neighbors of TLR1/2 heterodimer
Neighbors of FSH
Neighbors of TORC1
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of histone acetyltransferase
Neighbors of adrenoceptor
Neighbors of phosphodiesterase
Neighbors of caspase
Neighbors of phosphoinositide phospholipase C
Neighbors of deacetylase
Neighbors of TLR4/Myd88
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
PPARs and anxiety common targets
Amygdaloid expressed genes
PPARs and neuroinflamation
sars-cov no binding
dsRNA induces innate immunity and INFs in alveolar cells
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
Overview. Diseases of circulatory system (chapter 8)
Overview. Diseases of the skin (chapter 11)
Overview. Diseases of the digestive system (chapter 10)
Overview. Diseases of the musculoskeletal system (chapter 12)
Overview. Diseases of the nervous system (chapter 5)
Overview. Diseases of the respiratory (chapter 9)
Overview. Diseases of the genitourinary system (chapter 13)
Overview. Endocrine and metabolic diseases (chapter 4)
Overview. Infectious and parasitic diseases (chapter 2)
1_Differentiation of psoriatic T cells
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
3_Endoplasmic reticulum stress in age-related macular degeneration
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Cardiomyocyte hypertrophy
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
3_Impairment of iron release from splenic macrophages
1_Inflammatory mediators increase the production of hepcidin (HAMP)
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
2_SERPINA1-associated liver damage
1_Microangiopathy in diabetic neuropathy
drug-target pairs direct regulation
drug-target moltransport
New Combined Pathway
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atherosclerosis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Hashimoto's Thyroiditis
Proteins Involved in Graves Ophthalmopathy
Genes with Mutations Associated with Systemic Scleroderma
Genes with Mutations Associated with Multiple Sclerosis
Genes with Mutations Associated with Endometriosis
other partners for SARS

Source curated
ResNet
GO component

MedScan ID 3569

LocusLink ID 3569
16193
24498
280826

Alias interleukin IL6_HUMAN
beta 2 interferon
BSF2
IFNB2
OTTHUMP00000158544
OTTHUMP00000198486
interleukin-6 receptor ligands
plasmacytoma growth factor
interferon beta-2
IL-6 receptor ligand
interleukin BSF-2
interferon beta II
interleukin-6 receptor ligand
B-cell stimulatory factor 2
interleukin VI
IL6_HUMAN
B lymphocyte stimulating factor 2
interleukin IL6
liver cell stimulating factor
IFN-beta-2
beta interferon 2
B-cell hybridoma growth factor
hepatocyte stimulating factor
IL6
OTTHUMP00000198490
ILg6
hybridoma growth factor
interleukin 6
CTL differentiation factor
IL6R ligand
interleukin b
B-cell stimulatory factor II
B-cell stimulating factor 2
interleukin HP-1
CDF
HGF
HSF
IL-6
BSF-2
B-cell differentiation factor
interleukin-6
Interleukin 6 (interferon, beta 2)
interlukin 6
interferon, beta 2
B cell stimulatory factor-2
Interleukin-IL6
IL[6]
interleukin 6 (interferon
Interleukin 6 (interferon beta 2)
interleukin-6 precursor

GO ID 0005125
0008083
0005138
0072540
0006953
0044267
0070301
0071222
0019221
0050829
0050830
0051607
0031018
0070091
0002384
0006959
0006954
0070102
0002548
0043066
0045779
0008285
0045079
0032966
0045599
2000660
0010888
0050768
0070050
0031175
0001781
0002446
0030168
0050871
0051091
0046427
0043410
0051092
0042102
2000553
0002675
1902512
0043065
0008284
0032722
0010718
0090091
0010628
0060252
0051024
0045380
0032755
0002690
0150078
0045669
0033138
0050731
0048661
0045944
0045893
0045727
2000676
0042531
0010575
0043687
0045765
0061888
1905603
1903978
0150077
0010574
0051384
0032494
0005788
0005576
0005615
0005896
0005102
0042110
0060445
0045454
0035729
0071347
0071356
0042832
0060664
0042593
0006955
0046716
0002262
0043154
0050710
0045721
0046888
0045837
0048635
1901215
0006469
0045740
0070374
0045630
0071864
0050679
0014015
0045666
0010976
0045429
0051897
0051971
0042981
0042127
0008360
0045188
0009611
0005737
0009897
0002526
0007568
0046849
0071345
0071549
0071392
0031669
1990646
0031294
2000866
0010469
0043200
0046677
0010996
0009617
0031000
0051592
0009409
0034097
0042493
0051602
0009408
0032868
0032496
0009612
0031667
0014070
0001878
0042060
0033160
0016049
2000366
0042517
0005623
0045768
0043526
0043193
0051789
0030072
0005515
0007435
0007166
0007267
0001501
0007275
0008283

KEGG ID hsa:3569
mmu:16193
rno:24498

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9839821
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9854025
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9916891
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9933112
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10671302
10775602
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11992567
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12559950
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12928051
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12958150
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12969979
13678786
14508181
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14512079
14521945
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14532843
14557255
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14582815
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14607690
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14967376
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15016829
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15025214
15028733
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15044662
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15194822
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15230289
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15273081
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15299003
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15313471
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15345683
15373762
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15452323
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15469436
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15610507
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15780075
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15859365
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15951664
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16006475
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16519772
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16869943
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17083041
17097497
17101288
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17115422
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1883960
2472117
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3023045
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3320204
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3279116
3500852
7851440
8555185
9118960
9159484
10528216
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11867592
12133972
12207010
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14597766
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17615358
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17669273
17674319
2302197
2948184
3262059
3264160
7867561
9435302
9603480
9653168
16988192
17133350
17170234
17204394
17303338
17314490
17322172
17327367
17328769
17341596
17385713
17395896
17433709
17582939
17665433
1446077

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Human
mouse
murine

Mouse chromosome position 5 15.7 cM
5 17.0 cM

OMIM ID 147620
108010
222100
266600
148000
604302
125853
166710
OMIM:147620
OMIM:148000
OMIM:166710

Rat chromosome position 4q11

Hugo ID 6018
HGNC:6018

Human chromosome position 7p15.3
7p21

Swiss-Prot Accession B4DVM1
P05231
Q75MH2
B5MC21
B4DNQ5
P05231.1
A0A0G2JGF4
P08505
A2RTD1
P08505.1
P20607
P20607.1
Q9UCU2
Q9UCU3
Q9UCU4
Q3UCQ0
Q8BN26
Q8N6X1
Q0PMN1
Q3U8J8
IL6_HUMAN
IL6_MOUSE
IL6_RAT
Q75MH2_HUMAN
A2RTD1_MOUSE

PIR ID A32648
A30531
A34247

GenBank ID NC_000007
XM_011515390
XP_011513692
XM_005249745
XP_005249802
NM_000600
NP_000591
NM_001318095
NP_001305024
NG_011640
AC073072
AAS07539
AF005485
AF039224
AF039225
AF039226
AF039227
AF039228
AF048692
AAC05673
AF362378
AF372214
AAK48987
AY170325
AAN75009
CH236948
EAL24265
CH471073
EAW93756
EAW93757
EAW93758
CS352987
CAL23031
JA104583
CCA63961
JQ250825
AFF18412
KX430120
AOP17752
KX430126
AOP17758
KX430127
AOP17759
KX430128
AOP17760
KX430129
AOP17761
KX430130
AOP17762
KX430131
AOP17763
X04402
CAA27990
Y00081
CAA68278
A09363
CAA00839
AA721478
AK298013
BAG60317
AK298077
BAG60365
AK301141
BAG62733
BC015511
AAH15511
BT019748
AAV38553
BT019749
AAV38554
CD013918
CR450296
CAG29292
HY076725
M14584
AAA52728
M18403
AAA52729
M29150
AAA59154
M54894
AAC41704
S56892
AAD13886
X04403
CAA27991
X04430
CAA28026
X04602
CAA28268
P05231
NC_000071
NM_031168
NP_112445
NM_001314054
NP_001300983
AC112933
CH466524
EDL37257
EDL37258
M20572
AAA39302
M24221
AAA68814
M36996
X51457
CAA35824
AK089780
AK150440
BAE29562
AK152189
BAE31020
BC132458
AAI32459
BC138766
AAI38767
BC145409
DQ788722
ABG81953
J03783
AAA39301
X06203
CAA29560
X54542
CAA38411
P08505
NC_005103
NM_012589
NP_036721
AC_000072
AABR07059069
AAHX01027501
CH474057
EDL86435
M26745
AAA41430
M26744
AAA77659
P20607
XM_011515391
XP_011513693
NC_018918
AMYH02015349
DQ891463
ABM82389
DQ894639
ABM85565
AC_000027
AAHY01043243
AC_000139
ABBA01056696
XM_005249746
XP_005249803
AC_000068
AACC02000007
AABR06028560
NT_007819
NT_079592
NW_001839003
NW_923240
AC_000050
CR590965
CR626263
Q75MH2
Q8N6X1
NT_162294
NW_001030787
Q0PMN1
Q3U8J8
NW_047683
NW_001084822
NW_000226
NT_086703
124350
204916
204920
110671381
123784328
123792630
124348
124376266
309410
387386
52702
52728
581860
74212560
74219584
870699
119614162
119614164
123995927
124347
13899131
15930149
186352
23833
23835
29495
306910
306911
307063
32674
33850
41474122
4261586
47496539
490070
51095021
54696362
54696364
74729191
74739144
119614163
123981120
148705310
148705311
149031445
115304889
124346
2194
AAI23578
BC123577
CAA40572
NC_007302
NM_173923
NP_776348
NW_001494879
P26892
X57317
NT_039300
BAC40960
BC027978
AAH27978
NW_043536
NT_007819.11

Swiss-Prot ID IL6_HUMAN
IL6_MOUSE
IL6_RAT
B4DVM1_HUMAN
A2RTD1_MOUSE
Q75MH2_HUMAN

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000136244
ENSP00000258743.5
ENST00000258743.10
ENSP00000385043.1
ENST00000407492.5
ENSP00000385675.1
ENST00000404625.5
ENSMUSG00000025746
ENSMUSP00000143544.1
ENSMUST00000195978.4
ENSMUSP00000026845.7
ENSMUST00000026845.11
ENSRNOG00000010278
ENSRNOP00000013732.6
ENSRNOT00000013732.6
ENST00000258743.9
ENSP00000258743
ENST00000258743
ENSP00000385675
ENST00000404625
ENSP00000385043
ENST00000407492
ENSMUSP00000026845
ENSMUST00000026845
ENSRNOP00000013732
ENSRNOT00000013732
ENSP00000405994
ENST00000420258

MGI ID MGI:96559
96559

RGD ID 2901

Unigene ID Mm.1019
Rn.9873
Hs.654458
Hs.512234
Bt.3686
Hs.93913

Homologene ID 502

Shape Rhomb

IPI ID IPI00133702
IPI00007793
IPI00201260
IPI00878107
IPI00167115
IPI00878334
IPI00878660
IPI00877815
IPI00877634

Microarray ID 102218_at
A_32_P189757
I_1960905
A_32_P67060
I_1960906
1369191_at
M26744_at
M26745cds_s_at
A_43_P11475
NM_012589
1450297_at
x54542_s_at
Msa.849.0_at
A_51_P217218
NM_031168
M14584 >2
M14584 >1
38299_at
205207_at
X04602_s_at
Y00081_s_at
A_23_P71037
I_929482
A_14_P133151
A_23_P305818

Homo sapiens Chromosome position 7p21

Ensembl Transcript ID ENST00000258743
ENST00000404625

FunctionalClass cytokine
interleukin-6 receptor binding
protein binding
growth factor

Bos taurus Chromosome position 4

Mus musculus Chromosome position 5 17.0 cM

Proteome Subcellular Localization Extracellular (excluding cell wall)
Cytoplasmic

Compartment RNA

KEGG pathway Hematopoietic cell lineage
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Toll-like receptor signaling pathway

RefSeq ACCNUM NP_000591

Rattus norvegicus Chromosome position 4q11

Ensembl Gene ID ENSG00000136244

Keyword desmoplakin
map kinase
hnRNA
growth factor
cytokine receptor
exotoxin
interleukin-1 receptor ligand
acetyltransferase
desmoplakins
map kinases
binding activity
tumor necrosis factor
RNA
cytokine activity

LocatorString pmquery:curcumin+prostate+cancer
pmquery:curcumin prostate cancer
digtext:C:\Documents and Settings\yuryev\My Documents\Customers\Kristina Hettne\CPRS input entities.txt

Proteome Organismal Role Cell fate specification
Bone Development and Maintenance
Anti-pathogen response
Cell-to-cell signalling
Control of Cell Proliferation