Protein CXCL10

URN urn:agi-llid:3627
Total Entities 0
Connectivity 5018
Name CXCL10
Description chemokine (C-X-C motif) ligand 10
Notes This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway CXC Chemokine Receptor Signaling
Macrophage M1 Lineage
Nociception Expression Targets Signaling
CCR1 Expression Targets
Proteins Involved in Atherosclerosis
Chemokines Signaling in Atherosclerosis
Proteins Involved in Myocarditis
Proteins Involved in Psoriasis
Toll-like Receptors in beta-Cell
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
Proteins Involved in Graves Disease
Proteins Involved in Inflammatory Bowel Diseases
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
B-Cell Chronic Lymphocytic Leukemia
Mast-Cell Related Chemokines Signaling in Asthma
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Systemic Scleroderma
Proteins Involved in Glioma
Proteins Involved in Neuroblastoma
Proteins Involved in Multiple Sclerosis
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Proteins Involved in Age-Related Macular Degeneration
Proteins with Altered Expression in Asthma
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Glomerulonephritis
CCL3 Expression Targets
CCL7 Expression Target
CCL2 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
Elevated Receptors -> Expression Targets in Liver
EGFR -> Expression Targets in Skin
IFNB1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL13 Expression Targets
IL2 Expression Targets
Leptin -> STAT Expression Targets
Elevated Receptors -> Expression Targets in Lymph Node
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
CD40 -> Expression Targets in Thymus
CD40 -> Expression Targets in Lymph Node
Chemokine Receptor Family -> Expression Targets in Lymphoid System
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
Elevated Receptors -> Expression Targets in Respiratory System
TNF -> NF-kB Expression Targets
CD40LG -> STAT Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNF -> STAT Expression Targets
TLR3 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
Elevated Receptors -> Expression Targets in Kidney
VEGFA -> STAT Expression Targets
pathway 4
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of functional recovery
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of exhaustion
Neighbors of adverse outcome
Neighbors of cancer-specific survival
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of viral load
Neighbors of vascular leakage
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of renal hypertrophy
Neighbors of T-cell count
Neighbors of glucose level
Neighbors of functional status
Neighbors of neurological outcome
Neighbors of monocyte count
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of functional recovery
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of exhaustion
Neighbors of adverse outcome
Neighbors of cancer-specific survival
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of viral load
Neighbors of vascular leakage
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of renal hypertrophy
Neighbors of T-cell count
Neighbors of glucose level
Neighbors of functional status
Neighbors of neurological outcome
Neighbors of monocyte count
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of transcription activation
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of vasculitis
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of insulin-secreting cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of podocyte
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of synovial membrane
Neighbors of retina
Neighbors of brain
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of pancreas
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of immune system
Neighbors of spleen
Neighbors of vein
Neighbors of glands
Neighbors of eye
Neighbors of myelin sheath
Neighbors of bladder
Neighbors of trachea
Neighbors of mediastinal lymph node group
Neighbors of hair follicle
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of IgG
Neighbors of AMPK
Neighbors of LXR
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of IL12
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of SAPK
Neighbors of AHR subfamily
Neighbors of CD3 complex
Neighbors of TLR1/2 heterodimer
Neighbors of histone
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway (4)
IFN signaling in alveolar cells
Overview. Infectious and parasitic diseases (chapter 2)
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
drug-target moltransport

Group Proteins Involved in Graves Ophthalmopathy

MedScan ID 3627

LocusLink ID 3627
15945
245920

Alias Interferon-gamma induced protein 10
IFI10
SZ10_HUMAN
IP10
interferon-inducible protein-10
C-X-C motif chemokine ligand 10
crg-2
CXCL10
interferon-inducible cytokine IP-10
CXCL10 chemokine
protein 10 from interferon (gamma)-induced cell line
small inducible cytokine B subfamily (Cys-X-Cys) member 10
SCYB10
interferon activated gene 10
gIP-10
chemokine CXCL10
IFN-inducible protein 10
SZ10
Interferon-gamma-induced protein-10
OTTMUSP00000036425
gIP X
IFN-gamma-inducible protein 10
interferon-inducible cytokine IP X
interferon-gamma induced protein CRG-2
C-X-C motif chemokine 10
CXC ligand 10
chemokine (C-X-C motif) ligand 10
gamma IP10
Interferon-gamma-induced protein 10
10 kDa interferon gamma-induced protein
gamma interferon inducible protein 10
Small inducible cytokine B10
chemokine CXC ligand 10
IFNG-inducible protein 10
interferon-gamma inducible protein-10
CXC chemokine ligand 10
INP10
C7
IP-10
mob-1
small inducible cytokine subfamily B (Cys-X-Cys), member 10
small-inducible cytokine B10
gamma-IP10
small inducible cytokine B subfamily (Cys-X-Cys), member 10
interferon-inducible protein 10
protein Mob-1
crg II
interferon-gamma-induced protein CRG-2

GO ID 0048248
0008603
0042056
0008009
0008201
0005102
0007186
0010818
0007189
0061844
0008015
0007166
0007267
0034605
0071222
0070098
0006935
0019221
0051607
0042118
0006955
0006954
0030595
0007517
0016525
0045662
1901740
0030593
0050918
2000406
0008284
0090026
0051281
0045944
0010819
0042981
0042127
1901509
0045859
0010996
0009409
0010332
0033280
0007165
0009897
0005576
0005615
0005125
0006952
0030335
0002690
0009617
0010469
0032496
0009615
0005623
0009306
0030816
0006928
0043950
0045236

KEGG ID hsa:3627
mmu:15945
rno:245920

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 5 46.57 cM
5 53.0 cM

OMIM ID 147310

Rat chromosome position 14p22

Hugo ID 10637
HGNC:10637

Human chromosome position 4q21.1
4q21

Swiss-Prot Accession A0A024RDA4
P02778
P02778.2
P17515
Q548V9
P17515.1
P48973
P48973.2
Q96QJ5
P70538
Q6GTC7
Q3U6X5
Q3UAS6
Q3UCV1
Q3UK71

PIR ID A03243
A45492

GenBank ID NC_000004
NM_001565
NP_001556
AC112719
CH471057
EAX05772
EAX05773
AA321649
AA505379
BC010954
AAH10954
BF056337
X02530
CAA26370
P02778
NC_000071
NM_021274
NP_067249
AC109603
AC122365
CH466617
EDL05256
L07417
AAA75249
M86830
AF227743
AAG10400
AJ243095
AK144279
BAE25810
AK146144
BAE26931
AK150380
BAE29511
AK150765
BAE29832
AK150987
AK151210
BAE30205
AK151248
BAE30238
AK151415
BAE30380
AK151534
BAE30481
AK152568
BAE31320
AK152814
BAE31517
AK152838
AK152924
BAE31599
AK153181
BAE31783
AK156907
AK157130
BAE33973
AK157139
BAE33975
AK157589
BAE34130
AK157678
BAE34149
AK172540
BAE43058
BC030067
AAH30067
BC057150
BY165450
M33266
AAA02968
M86829
AAA21489
P17515
NC_005113
NM_139089
NP_620789
AC_000082
AAHX01078298
AC113621
CH474060
EDL88637
BC058444
AAH58444
FQ225009
FQ225217
FQ225221
FQ225582
FQ225670
FQ226479
FQ231406
FQ232883
FQ233441
FQ233623
FQ233884
FQ234688
U17035
AAB60485
U22520
AAC52811
P48973
DQ892786
AMYH02009504
AC_000027
ABM87032
AC_000136
AABR06077780
DQ896033
AAHY01046867
ABBA01063355
NC_018915
ABM83712
NT_016354
NW_922162
NW_001838915
AC_000047
NT_109320
NW_001030791
AK152234
Q3U6X5
Q3UAS6
Q3UCV1
Q3UK71
Q548V9
NW_001084690
NW_047423
NT_039339

Swiss-Prot ID CXL10_HUMAN
CXL10_MOUSE
CXL10_RAT
Q548V9_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000169245
ENSP00000305651.1
ENST00000306602.3
ENSMUSG00000034855
ENSMUSP00000047646.6
ENSMUST00000038816.12
ENSRNOG00000022256
ENSRNOP00000003649.4
ENSRNOT00000003075.7
ENSRNOP00000003649
ENST00000306602
ENSMUST00000038816
ENST00000306602.2
ENSRNOT00000003075
ENSMUSP00000047646
ENSP00000305651

MGI ID MGI:1352450
1352450

RGD ID 620209

Unigene ID Mm.877
Hs.632586
Rn.10584

Homologene ID 1203

Shape Rhomb

IPI ID IPI00022448
IPI00109915
IPI00231025
IPI00872038
IPI00880488