Protein CXCL1

URN urn:agi-llid:2493
Total Entities 0
Connectivity 3674
Name CXCL1
Description chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Notes This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
Primary Cell Localization Extracellular
Class Ligand

Pathway CXC Chemokine Receptor Signaling
Toll-like Receptor Independent Sterile Inflammation
Proteins Involved in Atherosclerosis
Chemokines Signaling in Atherosclerosis
IL17 Signaling in Psoriasis
Proteins Involved in non-Alcoholic Fatty Liver Disease
CagA Phosphorylation Independent Signaling
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Il17 Signaling Related Neutrophilia in Asthma
Neutrophil Recruitment in Sinovium in Gout
Cytokines Trigger Otitis Media
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
Endothelial Cell Dysfunction in Pyelonephritis
HMGB1 Expression Targets
CXCL1 Expression Targets
TAM Receptor Signaling Activation in Cancer
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
TNF -> NF-kB Expression Targets
LTA Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of mortality
Neighbors of survival rate
Neighbors of functional recovery
Neighbors of bacterial load
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of radioresistance
Neighbors of cell density
Neighbors of shear stress
Neighbors of leukocyte count
Neighbors of vascular leakage
Neighbors of cancer recurrence
Neighbors of antimetastatic activity
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of monocyte count
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of mortality
Neighbors of survival rate
Neighbors of functional recovery
Neighbors of bacterial load
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of disease-free survival
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of radioresistance
Neighbors of cell density
Neighbors of shear stress
Neighbors of leukocyte count
Neighbors of vascular leakage
Neighbors of cancer recurrence
Neighbors of antimetastatic activity
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of monocyte count
Neighbors of immune response
Neighbors of cell population
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of cell motility
Neighbors of monocyte migration
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of ossification
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of injury
Neighbors of atherogenesis
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of lung injury
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of melanoma
Neighbors of cartilage degeneration
Neighbors of neoplasm invasion
Neighbors of heart failure
Neighbors of lung disease
Neighbors of stroke
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of neointima
Neighbors of diet-induced obesity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of hematopoietic cell
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of pericyte
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of lymphocyte
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of skin cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of microvessel
Neighbors of placenta
Neighbors of synovial membrane
Neighbors of brain
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of prostate
Neighbors of spleen
Neighbors of allantois
Neighbors of hippocampus
Neighbors of cerebral cortex
Neighbors of draining lymph node
Neighbors of cervical lymph node group
Neighbors of amniotic cavity
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of IKBK
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of LXR
Neighbors of HDL
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of mitogen-activated protein kinase kinase
Neighbors of interleukin-35
Neighbors of endothelin
Neighbors of proteasome endopeptidase complex
Neighbors of histone H3
Neighbors of PP2A
Neighbors of phospholipase
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of histone
Neighbors of Rho kinase
Neighbors of pancreatic elastase
Neighbors of phosphoinositide phospholipase C
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
Overview. Endocrine and metabolic diseases (chapter 4)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_The role of endothelial cells in pyelonephritis
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
drug-target moltransport
drug-target molsynthesis
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 2493

LocusLink ID 2493
2919
330122
171551

Alias chemokine (C-X-C motif) ligand I
melanoma growth-stimulating activity
melanoma growth-stimulation activity
MGSA alpha
GRO1 oncogene
small inducible cytokine B1
melanoma growth stimulatory activity factor alpha
MGSA/GRO
Cxcl I
Growth-regulated oncogene alpha
GRO-alpha(1-73)
GROA
GRO alpha
Fsp
SCYB1
CXCL1 chemokine
cytokine induced neutrophil chemokine CINC-1
NAP III
chemokine (C-X-C motif) ligand 1
Neutrophil-activating protein III
melanoma growth-stimulatory activity
CINC-1
MGSA-a
GRO1
CXC chemokine ligand 1
Neutrophil-activating protein 3
GRO1 oncogene (melanoma growth-stimulating activity)
SCYB I
melanoma growth-stimulatory activity factor
NAP-3
MGSA
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chemokine CXC ligand 1
N51 protein
C-X-C motif chemokine ligand 1
melanoma growth-stimulatory activity factors
melanoma growth stimulating activity, alpha
cytokine-induced neutrophil chemoattractant I
melanoma growth stimulatory activity alpha
CXCL1
Growth regulated protein precursor alpha
CXC ligand 1
cytokine-induced neutrophil chemoattractant 1
fibroblast secretory protein
chemokine CXCL1
GRO I
GRO_HUMAN
GRO1 oncogene (melanoma growth stimulating activity, alpha)
C-X-C motif chemokine 1
growth-regulated alpha protein
Dcip1
Gm1960
C-X-C motif chemokine 3
dendritic cell inflammatory protein 1
Cinc2
Cinc-2
MIP2-alpha/beta
macrophage inflammatory protein 2-alpha/beta
cytokine-induced neutrophil chemoattractant 2
cytokine-induced neutrophil chemoattractant-2
NAP IIIs
small inducible cytokine B subfamily
gro

GO ID 0008009
0008047
0008083
0005102
0007186
0030036
0061844
0071222
0070098
0006935
0019221
0006955
0006954
0035556
0030595
0008285
0007399
0030593
0043312
0043085
0007165
0005576
0005615
0035580
1904724
0045236
0060326
0008283
0090023
0032496
0005622
0002690
0005125
0007204

KEGG ID hsa:2919
mmu:330122
rno:171551

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 5

OMIM ID 155730

Rat chromosome position 14p22

Hugo ID 4602
HGNC:4602

Human chromosome position 4q13.3
4q21

Swiss-Prot Accession P09341
P09341.1
Q9UCR7
Q6W5C0
Q10746
Q10747
Q5CZ55
Q9EP62
Q3UNK9

PIR ID S13669
S46198

GenBank ID NC_000004
NR_046035
NM_001511
NP_001502
AC092438
CH471057
EAX05693
HI519534
CBX54348
JA514411
CCD62019
M65005
AAP13103
U03018
AAA03452
X54489
CAA38361
BC011976
AAH11976
BG121608
BM554448
BM996663
BQ000742
BT006880
AAP35526
CB112830
J03561
AAA35933
X12510
CAA31027
P09341
NC_018915
AMYH02009472
DQ893591
ABM84517
DQ894941
ABM85867
AC_000136
ABBA01022993
NC_000071
NM_203320
NP_976065
NT_109599
AC_000027
AC105995
AC113262
AY311404
AAQ86937
CH466617
EDL05303
AK144158
BAE25738
AK150314
BAE29460
AK154334
BAE32520
AK155702
AY311403
AAQ86936
BC117014
AAI17015
BC117016
AAI17017
Q6W5C0
NC_005113
NM_138522
NP_612531
AC_000082
CH474060
EDL88570
EDL88571
EDL88572
EDL88573
D87926
BAB12279
BAB12336
D21095
BAA04657
D87927
BAB12280
Q10746

Swiss-Prot ID GROA_HUMAN
CXCL3_RAT
CXCL3_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000163739
ENSP00000379110.3
ENST00000395761.3
ENSP00000379110
ENST00000395761

MGI ID 3037818

RGD ID 621812

Unigene ID Hs.789
Hs.708652
Mm.244289
Rn.10525

Homologene ID 117693

Shape Rhomb

IPI ID IPI00366205
IPI00778837
IPI00013874
IPI00356181