Protein TBX21

URN urn:agi-llid:29939
Total Entities 0
Connectivity 2180
Name TBX21
Description T-box 21
Notes This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway CD8+ T-Cell Activation
Th1-Cell Differentiation
AHR Signaling in Tr1 Cells Function
Proteins Involved in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
Th1-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Proteins Involved in Myasthenia Gravis
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Proteins Involved in Helicobacter Infections
Proteins Involved in Ulcerative Colitis
Proteins Involved in Systemic Scleroderma
Proteins Involved in Spontaneous Abortion
Proteins Involved in Glomerulonephritis
CD80 -> ATF/CREB/CREBBP Expression Targets
IFNA1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL27R -> STAT Signaling
IL21 Expression Targets
IL15 Expression Targets
NOTCH -> Expression Targets in Thymus
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
IL1B Expression Targets
IL1A Expression Targets
PPAR Psoriasis
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative regulators
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of body weight
Neighbors of morbidity
Neighbors of exhaustion
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of antimetastatic activity
Neighbors of gastric cancer risk
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of body weight
Neighbors of morbidity
Neighbors of exhaustion
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of antimetastatic activity
Neighbors of gastric cancer risk
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of innate immune response
Neighbors of cell function
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of adipogenesis
Neighbors of pregnancy
Neighbors of neutrophil recruitment
Neighbors of cell migration
Neighbors of leukocyte migration
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of hyperplasia
Neighbors of chronic obstructive pulmonary disease
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of macrophage infiltration
Neighbors of neuroinflammation
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of heart disease
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of interstitial fibrosis
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of pulmonary fibrosis
Neighbors of cancer
Neighbors of neoplasm
Neighbors of vasculitis
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of hypertension
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of PBMC
Neighbors of B-cell
Neighbors of T-cell
Neighbors of spleen cell
Neighbors of lymphoid cell
Neighbors of blood cell
Neighbors of colon
Neighbors of airway
Neighbors of heart
Neighbors of gastrointestinal tract
Neighbors of thymus gland
Neighbors of reproductive system
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of PPAR
Neighbors of NFKBI
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of JAK
Neighbors of ERK1/2
Neighbors of ovalbumin
Neighbors of NF-AT family
Neighbors of SMAD subfamily
Neighbors of LXR
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of T-cell receptor
Neighbors of IL12
Neighbors of Notch
Neighbors of fibrinogen
Neighbors of interleukin-35
Neighbors of proteasome endopeptidase complex
Neighbors of histone H3
Neighbors of STAT5
Neighbors of WNT
Neighbors of immunoglobulin
Neighbors of CD3 complex
Neighbors of TORC1
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
IFN signaling in alveolar cells
Overview. Diseases of the digestive system (chapter 10)
1_Differentiation of psoriatic T cells
4_2_Genes with mutations currently associated with ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
Differentiation of psoriatic T cells

MedScan ID 29939

LocusLink ID 29939
30009
57765
303496

Alias TBT I
OTTMUSP00000002150
TBX21
protein T bet
T-box expressed in T cells
transcription factor TBLYM
T-bet protein
T bet protein
T-cell-specific T-box transcription factor
T-bet
T-box transcription factor TBX21
transcription factor T bet
T-PET
t-box transcription factor
TBET
T box expressed in T cells transcription factor
T-box 21
T-cell-specific T-box transcription factor T-bet
T-box transcription factor 21
RP23-428N4.9
TBLYM
T-box protein 21
TBT1
Tbx21_predicted

GO ID 0001228
0003700
0000981
0001227
0001102
0000977
0043565
0044212
0030217
0001708
0071310
0072676
0007275
2000320
2000329
2000552
0032703
0000122
0045892
0048304
0045944
0045893
0043161
0045580
0006355
0009615
0043025
0005634
0003677
0010628
0050776
0006351

KEGG ID hsa:30009
mmu:57765
rno:303496

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 11

OMIM ID 604895
208550

Rat chromosome position 10q31

Hugo ID 11599
HGNC:11599

Human chromosome position 17q21.32

Swiss-Prot Accession Q9UL17
Q9UL17.1
Q9JKD8
Q9JKD8.1
D3ZCM2
Q3U150
Q9R0A6
Q53EK5
Q5PSB0

GenBank ID NC_000017
NM_013351
NP_037483
NG_012166
AC015674
CH471109
EAW94804
GN337430
CAY39299
GN337449
CAY39301
AF093098
AAF00055
AF241243
AAF61243
AK223634
BAD97354
BC039739
AAH39739
Q9UL17
NC_000077
NM_019507
NP_062380
AL606664
AL627445
BX255873
CH466556
EDL16071
GN337432
CAY39300
GN337451
CAY39302
AF093099
AAF00056
AF241242
AAF61242
AK054495
AK156271
BAE33650
AY836551
AAV83787
BC137986
AAI37987
BC137988
AAI37989
Q9JKD8
NC_005109
NM_001107043
NP_001100513
AC_000078
AABR07030424
AABR07030425
AAHX01065830
AAHX01065831
AAHX01065832
CH473948
EDM05847
ABBA01041142
XP_011523000
XP_011523001
XM_011524699
XM_011524698
AAHY01095630
NC_018928
CAM26989
AMYH02033526
AABR06065461
CAM24010
AABR06065460
AC_000149
AC_000033
NT_010783
NW_001838448
NW_926894
AC_000060
Q53EK5
NT_165773
NW_001030424
Q3U150
Q5PSB0
NW_001084656
NW_047338

Swiss-Prot ID TBX21_HUMAN
TBX21_MOUSE
Q3U150_MOUSE
D3ZCM2_RAT

Cell Localization Nucleus

Ensembl ID ENSG00000073861
ENSP00000177694.1
ENST00000177694.2
ENSMUSG00000001444
ENSMUSP00000001484.2
ENSMUST00000001484.2
ENSRNOG00000009427
ENSRNOP00000012538.5
ENSRNOT00000012538.5
ENST00000177694.1
ENSMUSP00000001484
ENSRNOT00000012538
ENSRNOP00000012538
ENSMUST00000001484
ENSP00000177694
ENST00000177694

MGI ID MGI:1888984
1888984

RGD ID 1308264

Unigene ID Hs.272409
Mm.94519
Rn.144930
Mm.490611
Mm.485627

Homologene ID 8353

Shape O-vertex

IPI ID IPI00007732
IPI00311393
IPI00370968