URN | urn:agi-llid:3595 |
---|---|
Total Entities | 0 |
Connectivity | 478 |
Name | IL12RB2 |
Description | interleukin 12 receptor, beta 2 |
Notes | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
Pathway | CD8+ T-Cell Activation |
---|---|
Th1-Cell Differentiation | |
Th17-Cell Differentiation | |
T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers | |
Th1-Cells Activation and Proliferation in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Atopic Dermatitis | |
T-Cells Differentiation Block in Psoriasis | |
Th17-Cell Function in Systemic Lupus Erythematosus | |
Th1-Cell Function in Systemic Lupus Erythematosus | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
Toll-like Receptors in beta-Cell | |
CD4+T-Cell Response in Celiac Disease | |
Th1-Cell Activation in Crohn's Disease | |
Th17-Cell Activation in Crohn's Disease | |
Follicular Lymphoma | |
Il17 Signaling Related Neutrophilia in Asthma | |
Th17-Cell Differentiation in Asthma | |
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis | |
Th17-Cell Numbers Reduction in HIV | |
IL12R -> STAT Signaling | |
IL23R -> STAT3/NF-kB Signaling | |
IL12R -> NF-kB/NFATC Signaling | |
IL12B Expression Targets | |
CD40 -> Expression Targets in Thymus | |
PPAR Psoriasis | |
1_Differentiation of psoriatic T cells | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
Differentiation of psoriatic T cells |
Group | Genes Frequently Hypermethylated in Follicular Lymphoma |
---|
MedScan ID | 3595 |
---|
LocusLink ID | 3595 |
---|---|
16162 | |
171334 |
Alias | interleukin IL-12 receptor beta 2 |
---|---|
interleukin 12 receptor, beta II | |
interleukin-12 receptor subunit beta-2 | |
IL12rb2 | |
IL-12 receptor beta II | |
interleukin IL12rb2 | |
OTTHUMP00000010662 | |
Ifnm | |
interleukin 12 receptor beta 2 subunit | |
interleukin IL-12 receptor beta II | |
IL-12 receptor beta 2 | |
IL-12R subunit beta-2 | |
interferon response to microorganisms | |
RP11-102M16.1 | |
A930027I18Rik | |
A930027I18 | |
IL-12 receptor subunit beta-2 | |
RIKEN cDNA A930027I18 gene | |
I12S_HUMAN | |
interleukin 12 receptor, beta 2 | |
interleukin IL-12R-beta2 | |
IL-12R-beta2 | |
interleukin-12 receptor beta-2 chain | |
IL-12RB2 | |
IL-12R-beta-2 |
GO ID | 0019955 |
---|---|
0004896 | |
0019901 | |
0007166 | |
0032609 | |
0035722 | |
0070757 | |
0018108 | |
0008284 | |
0032729 | |
0032496 | |
0009897 | |
0005887 | |
0005886 | |
0043235 | |
0034097 | |
0016021 | |
0016020 | |
0019221 | |
0045622 | |
0004872 | |
0007165 |
KEGG ID | hsa:3595 |
---|---|
mmu:16162 | |
rno:171334 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 6 30.81 cM |
---|---|
6 30.1 cM |
OMIM ID | 601642 |
---|
Rat chromosome position | 4q31 |
---|
Hugo ID | 5972 |
---|---|
HGNC:5972 |
Human chromosome position | 1p31.3 |
---|---|
1p31.3-p31.2 |
Swiss-Prot Accession | B4DGA4 |
---|---|
Q99665 | |
A0A0A0MTN7 | |
B7ZB60 | |
Q99665.1 | |
D3Z6H5 | |
P97378 | |
P97378.1 | |
F1LRH7 | |
B1AN98 | |
B7ZKL9 | |
F5H7L6 | |
Q2M3V3 | |
B9EHD9 | |
Q9Z0Z1 |
Swiss-Prot ID | I12R2_HUMAN |
---|---|
I12R2_MOUSE | |
B1AN98_HUMAN | |
B9EHD9_MOUSE |
Cell Localization | Membrane |
---|---|
Plasma membrane |
Ensembl ID | ENSG00000081985 |
---|---|
ENSP00000360039.1 | |
ENST00000371000.5 | |
ENSP00000442443.1 | |
ENST00000544434.5 | |
ENSP00000445276.2 | |
ENST00000541374.5 | |
ENSP00000262345.1 | |
ENST00000262345.5 | |
ENSP00000497959.1 | |
ENST00000648487.1 | |
ENSMUSG00000018341 | |
ENSMUSP00000113267.1 | |
ENSMUST00000117441.7 | |
ENSMUSP00000010605.3 | |
ENSMUST00000018485.3 | |
ENSRNOG00000007270 | |
ENSRNOP00000009883.5 | |
ENSRNOT00000009883.6 | |
ENSP00000360039 | |
ENST00000371000 | |
ENSP00000442443 | |
ENST00000544434 | |
ENSP00000445276 | |
ENST00000541374 | |
ENSP00000262345 | |
ENST00000262345 | |
ENSMUSP00000010605 | |
ENSMUST00000018485 | |
ENSMUSP00000113267 | |
ENSMUST00000117441 | |
ENSRNOP00000009883 | |
ENSRNOT00000009883 |
MGI ID | MGI:1270861 |
---|---|
1270861 |
RGD ID | 620026 |
---|
Unigene ID | Hs.479347 |
---|---|
Rn.207395 | |
Mm.188337 |
Homologene ID | 1197 |
---|
Shape | Stick-vertex |
---|
IPI ID | IPI00438855 |
---|---|
IPI00438856 | |
IPI00124243 | |
IPI00479253 | |
IPI00881142 | |
IPI00358054 |