Pathway
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Osteoarthritis
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Th17-Cell Differentiation
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Bradykinin Effects in Inflammation
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Toll-like Receptor Independent Sterile Inflammation
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Mast-Cell Activation without Degranulation
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Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
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anti-Inflammatory Function of Macrophage M2 Lineage
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Negative Acute Phase Proteins Synthesis
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Positive Acute Phase Proteins Synthesis
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Vascular Endothelial Cell Activation by Cytokines
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IL1B Expression Targets -> Nociception
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CD8+ Naive T-cell -> CD4+ Naive T-cell Surface Expression Markers
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Megakaryocyte -> Platelet Precursor Cell Surface Expression Markers
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T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers
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Lymphocyte Mediated Myocardial Injury in Myocarditis
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Proteins Involved in Myocarditis
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Inflammatory Reaction in Acne Vulgaris
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Keratinocyte Proliferation in Acne Vulgaris
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T-Cells Differentiation Block in Psoriasis
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Th17-Cell Function in Systemic Lupus Erythematosus
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Vitiligo
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T-Cell Cytotoxic Response against Melanocytes in Vitiligo
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Toll-like Receptors in beta-Cell
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beta-Cell Destruction through Cytokines in Diabetes Mellitus
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beta-Cell Destruction in Diabetes Mellitus Type 1
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Nitric Oxide Effects on beta-Cell
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CD4+T-Cell Response in Celiac Disease
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Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
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TSLP Signaling in Bronchial Epithelial Cell in Asthma
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Th17-Cell Differentiation in Asthma
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CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
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CFTR Expression in Epithelial Cells (Class I Mutations)
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Osteoclast Activation in Gout
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Neutrophil Recruitment in Sinovium in Gout
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TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
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IL1B Induced Arthralgia
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Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
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Osteoclast Activation in Psoriatic Arthritis
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Synovial Fibroblast Activation in Psoriatic Arthritis
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Osteoclast Activation in Rheumatoid Arthritis
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Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
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Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
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Th17-Cell Numbers Reduction in HIV
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IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
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IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
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HMGB1 and IL1B in Neuroinflammation
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HMGB1 and IL1B in Neuronal Hyperexcitation
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Proteins Involved in Endometriosis
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Subepithelial Fibroblasts in Middle Ear Cholesteatoma
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Cytokines Trigger Otitis Media
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Alveolar Macrophages Dysfunction in COPD
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Mucin Hyperproduction in Goblet and Mucous Cells
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Endothelial Cell Dysfunction in Glomerulonephritis
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Endothelial Cell Dysfunction in Pyelonephritis
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Elevated Receptors -> Expression Targets in Blood vessel
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Elevated Receptors -> Expression Targets in Blood Vessel
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Elevated Receptors -> Expression Targets in Small Intestine
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NFKB Canonical Signaling Activation in Cancer
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STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
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NFKB Signaling Activation by Blocking of Tumor Suppressors
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IDO1 in Cancer Immune Escape
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IGF1 -> CEBPA/FOXO1A Expression Targets
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IL1R -> STAT3 Signaling
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IL1R -> NF-kB Signaling
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IL6 Expression Targets
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Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
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Elevated Receptors -> Expression Targets in Nerve Tissue
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NF-kB Canonical Signaling
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TLR4 -> AP-1/EGR1/HIF1A Expression Targets
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IL1B Expression Targets
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IL1A Expression Targets
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PPAR Psoriasis
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Model of PPARG signaling in psoriasis
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1_Inflammation in keratinocytes in the pathology of acne
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1_Differentiation of psoriatic T cells
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1_TNF and IL1B provoke ECM degradation in osteoarthritis
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2_Chondrocyte death in osteoarthritis
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2_The role of endothelial cells in pyelonephritis
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1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
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2_Pathogens stimulate mucins expression in the middle ear
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3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
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3_1_Mucus accumulation in asthma
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4_Mucin hyperproduction in goblet and mucous cells in COPD
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3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
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1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
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1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
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3_Islet beta-cell destruction in T1D
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Differentiation of psoriatic T cells
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