Protein PPARG

URN urn:agi-llid:5468
Total Entities 0
Connectivity 13252
Name PPARG
Description peroxisome proliferator activated receptor gamma
Notes This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Oxidative Stress in Amyotrophic Lateral Sclerosis
Estrogen Deficiency in Female Obesity
Androgen Deficiency in Male Obesity
mTOR Signaling
A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
Thyroid Hormones Common Genomic Effects in Hyperthyroidism
Androgens in Adipocyte Activation
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Mast-Cell Activation via IgE Signaling
Neutrophil Recruitment and Priming
Gastric and Pancreatic Lipase Function
Adipokines Production by Adipocyte
Peroxisome Protein Import and Peroxisome Division
Proteins Involved in Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy
Proteins Involved in Atherosclerosis
Low-Density Lipoproteins and Chemokines in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension
Proteins Involved in Myocarditis
Sebocyte Proliferation in Acne Vulgaris
Hyperseborrhea in Acne Vulgaris
Androgens in Sebocyte Maturation
Proteins Involved in Melanoma
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Familial Partial Lipodystrophy Type 4 Progression (Hypothesis)
Familial Partial Lipodystrophy Type 3 Progression (Hypothesis)
Familial Partial Lipodystrophy Type 2 Progression (Hypothesis)
Berardinelli-Seip Syndrome Progression (Hypothesis)
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Diabetic Neuropathy
Proteins Involved in Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
beta-Cell Recovery in Diabetes Mellitus
Thyroid Hormones in Adipose Tissue Metabolism
Adipocyte Hypertrophy and Hyperplasia
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Helicobacter Infections
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Mast-Cell Activation in Asthma
Proteins Involved in Osteoarthritis
Proteins Involved in Polycystic Ovary Syndrome
Proteins Involved in Psoriatic Arthritis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Periodontitis
PPARGC1A Repression in Huntington Disease
Proteins Involved in Huntington Disease
Proteins Involved in Lipodystrophy, Familial Partial
Lipodystrophy, Familial Partial
Proteins Involved in Osteopetrosis
Proteins Involved in Alzheimer's Disease
Proteins Involved in Glioma
Proteins Involved in Neuroblastoma
Proteins with Altered Expression in Amyotrophic Lateral Sclerosis
Proteins Involved in Endometriosis
Proteins Involved in Cholesteatoma
Fatty Acid Synthase (FASN) Signaling
Proteins Involved in Prostate Cancer
Proteins Involved in Chronic Obstructive Pulmonary Disease
Elevated Receptors -> Expression Targets in Adipose Tissue
CSF2 -> STAT Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> STAT Expression Targets
VEGFA Dependent Angiogenesis in Cancer
Cancer Cells Inhibit Adipocyte Differentiation
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IL13 Expression Targets
IL11 Expression Targets
IL4 Expression Targets
Leptin -> STAT Expression Targets
LDLR -> Expression Targets in Lymphoid System and Blood
OR1A1 -> GNAS Signaling
OSM/OSMR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
Lysophosphatidic Acid/LPARs Signaling
FOXO1 Signaling
TGFB1-ACVRL1 Expression Targets
TNF -> STAT Expression Targets
New Pathway (1)
PPAR Psoriasis
prarg negative regulators, ps-positive
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG inhibits phenotypes assotiated with psoriasis
PPARG expressed in cells assotiated with psoriasis
efects selected
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway (5)
PPARG-CCK4_MME
PPARs and anxiety common targets
Amygdaloid expressed genes
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
3_Increased proliferation of sebocytes in acne vulgaris
2_Hyperseborrhea in acne vulgaris
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
1_Intestine epithelial cell dysfunction in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Triglyceride storage in NAFLD
3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation
4_3_Insulin resistance: FFA-related insulin resistance
2_2_Effects of thyroid hormone deficiency: cell-specific effects of thyroid hormone action
drug-target pairs direct regulation
Model of PPARG signaling in psoriais (tested)
before laser treatment
mapk1
Anti-psoriatic drugs influence PPARG signaling
PPARG signaling after laser treatment

Group Genes with Mutations Associated with Atherosclerosis
Proteins Involved in Graves Ophthalmopathy
Genes with Mutations Associated with Obesity
Genes Associated with Ulcerative Colitis
Genes with Mutations Associated with Familial Partial Lipodystrophy

MedScan ID 5468

LocusLink ID 5468
19016
25664

Alias peroxisomal proliferator activated receptor gamma 2
OTTHUMP00000185030
PPARc
PPAR-gamma
Peroxisome proliferator activated receptor gamma
PPARG
HUMPPARG
PPARG I
PPAR-C
peroxisome proliferative activated receptor gamma isoform I
peroxisomal proliferator (PP)-activator receptor gamma
peroxisomal proliferator activated receptor-c
peroxisome proliferators-activated receptor gamma
peroxisomal proliferator-activator receptor gamma
nuclear receptor subfamily 1 group C member 3
OTTHUMP00000185032
peroxisome proliferator-activated receptor gamma 1
peroxisome proliferator activated receptor gamma 2
PPAR-gamma2
peroxisome proliferator (PP)-activator receptor gamma
OTTHUMP00000185036
peroxisome proliferative activated receptor gamma isoform II
PPARG2
NR1C3
peroxisome proliferator (PP)-activated receptor gamma
peroxisome proliferative activated receptor gamma isoform 1
OTTHUMP00000185033
CIMT1
PPARG1
peroxisome proliferator-activator receptor gamma
peroxisome proliferative activated receptor gamma
peroxisomal proliferator (PP)-activated receptor gamma
peroxisome proliferators-activated receptor gamma 1
peroxisome proliferative activated receptor gamma isoform 2
OTTHUMP00000185037
peroxisome proliferator-activated nuclear receptor gamma variant 1
peroxisomal proliferator-activated receptor gamma 1
peroxisomal proliferator activated receptor gamma
peroxisome proliferator activated receptor gamma 4
PPAR-G
GLM1
PPARgamma
peroxisome proliferator-activated receptor gamma
PPARgamma2
peroxisome proliferator activator receptor, gamma
PPAR gamma

GO ID 0050692
0003677
0003700
0000981
0001227
0070888
0050693
0000977
0001103
0033613
0051393
0050544
0003682
0003690
0008144
0019899
0030331
0005504
0008289
0004879
0030374
0042277
0004955
0008022
0046982
0019903
0043621
0046965
0043565
0038023
0003707
0008134
0044212
0000976
0008270
0007186
0006919
0031100
0030154
0045165
0048469
0071455
0032869
0071404
0071380
0071300
0071306
0030855
0006631
0019395
0042593
0007507
0009755
0045087
0055088
0006629
0042953
0015909
0045713
0010742
0030224
0007275
0002674
0016525
0043537
0030308
0010887
0032966
0060965
0060336
0010745
2000230
0010871
0010891
0048662
0051974
0000122
0045892
1905563
1904706
0035357
0001890
0043388
0051091
0045600
0046321
0048714
0060100
0045944
0045893
1905461
0061614
0008217
0060694
0042752
0019216
0006357
0060850
0031000
0009409
0043627
0035902
0033993
0009612
1901558
0007584
0032526
0042594
0033189
0048511
0007165
0043401
0006367
0050872
0090575
0005829
0043231
0005654
0005634
0048471
0032991
0001228
0001012
0050699
0046872
0050873
0071285
0071407
0002024
0045444
0006954
0008285
1900077
0001818
1903979
0150079
0090278
0043065
0045598
0010468
0006355
0002021
0032094
0009416
0005737
0071379
0010629
0010875
0032385
0031394
0050714
1903076
0042493
0014070
0010033
0045923
0071396
0050728
0098531
0006351
0031667
0001076
0001078
0001046
0030522
0010467
0036270
0055098
0005794
0006366
0006917
0032717
0010843
0016566
0016563
0016564
0010553
0010552
0034339
0004872
0017053

KEGG ID hsa:5468
mmu:19016
rno:25664

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6 53.41 cM
6 52.7 cM

OMIM ID 601487
609338
125853
604367
601665
137800
151660

Rat chromosome position 4q42

Hugo ID 9236
HGNC:9236

Human chromosome position 3p25.2
3p25

Swiss-Prot Accession E9PFX5
Q4W448
D2KUA6
P37231
P37231.3
M1VPI1
P37238
Q6GU14
P37238.3
O88275
O88275.2
A8K3G6
B5BUA1
O00684
O00710
O14515
Q0QJH8
Q15178
Q15179
Q15180
Q15832
Q86U60
Q96J12
Q9QWG0
Q9R197
Q4FJR2
Q4W4C6
Q4W4C7
Q53EW1
Q6L9M1
Q86WD1
Q9UEF6
Q6TQE4

PIR ID JC4859
PC4290
PC4429
A54101

GenBank ID NC_000003
NM_001354666
NP_001341595
NM_138712
NP_619726
NM_001354669
NP_001341598
NM_005037
NP_005028
NM_138711
NP_619725
NM_001354667
NP_001341596
NM_001354670
NP_001341599
NM_001330615
NP_001317544
NM_001354668
NP_001341597
NM_015869
NP_056953
NG_011749
AB005520
BAA23353
AB005526
BAA23354
AC090947
AC091492
AC093174
AF012873
AF012874
AF310249
AAK17925
AF548352
AY157024
AAN38992
CH471055
EAW64123
EAW64124
EAW64125
HI519538
CBX54350
KF457590
KY547832
ARH59648
KY547833
ARH59649
KY547834
ARH59650
KY547835
ARH59651
KY547836
ARH59652
AB097931
BAD20647
AB107271
BAD34540
AB307692
BAH02283
AB451337
BAG70151
AB451486
BAG70300
AB472042
BAI63629
AB565476
BAM71699
AJ563369
CAD91388
AJ563370
CAD91389
AJ698135
CAG29019
AK027107
AK123253
AK223528
BAD97248
AK290581
BAF83270
AL523434
BC006811
AAH06811
BG323933
BI820841
BM923992
BQ003677
BQ925271
BT007281
AAP35945
D83233
BAA18949
DQ356894
ABC97372
HQ692866
ADZ17377
KU178267
ALQ33725
KU178268
ALQ33726
LS999978
VAX75249
LS999979
VAX75250
LS999980
VAX75251
U63415
AAB04028
U79012
AAC51248
X90563
CAA62152
CAA62153
P37231
NC_000072
XM_006505743
XP_006505806
NM_001127330
NP_001120802
NM_001308352
NP_001295281
XM_006505737
XP_006505800
XM_006505739
XP_006505802
XM_017321455
XP_017176944
XM_017321456
XP_017176945
XM_006505738
XP_006505801
NM_001308354
NP_001295283
XM_011241252
XP_011239554
XR_001785108
NM_011146
NP_035276
AB256529
BAF80899
AB256530
BAF80900
AC153828
AC171970
AH012542
AH012543
AH012840
AH013272
AH013273
AH013274
AAQ89994
AY236530
AY236531
AY243584
AY389534
AY389535
AY389536
CH466523
EDK99525
EF062477
ABK39949
EF062478
EF062479
ABK39950
AB644275
BAM95277
AY208183
AAO45097
AY208184
AAO45098
AY243585
AAP42200
BC021798
AAH21798
CJ043379
CN701591
CT010340
CAJ18548
EF062476
ABK39948
GQ868647
ACX47078
GQ868648
ACX47079
GQ868649
ACX47080
GQ868650
ACX47081
U01664
AAA62110
U01841
AAC52134
U09138
AAA62277
U10374
AAA19971
P37238
NC_005103
XM_006237009
XP_006237071
NM_001145367
NP_001138839
NM_001145366
NP_001138838
NM_013124
NP_037256
AC_000072
AAHX01032447
AAHX01032448
AAHX01032449
AAHX01032450
AAHX01032451
AC094445
AC136055
CH473964
EDM02154
EDM02155
EDM02156
AB011365
BAA32540
AB019561
BAA36485
AF156665
AAD40118
AF156666
AAD40119
AF246457
AAF63385
AF246458
AAF63386
Y12882
CAA73382
O88275
AY243582
AY243583
XP_011532144
XP_011532145
XP_011532146
XP_024309374
XP_024309373
XP_024309372
AY389545
AY389543
AY389541
AY389540
AY389529
AY389538
AY389539
AY389537
XM_011533842
XM_011533843
XM_011533844
XM_024453606
XM_024453604
XM_024453605
DQ891108
AY389528
XM_006713208
DQ894289
XP_011532142
XP_011532143
AC_000028
XP_006713271
ABM82034
XP_006505808
XP_006505807
XP_006505804
XP_006505803
XP_006505805
NC_018914
AY389544
AY389542
AAQ89993
AAQ89992
AY389532
ABM85215
AY389533
AY389530
AY389531
AMYH02006292
AMYH02006290
AMYH02006291
XM_011241253
AY236532
AY236534
AY236533
AY236536
AY236535
AY236537
XM_006505742
XM_006505741
XM_006505740
XP_011239555
XM_006505745
XM_006505744
AC_000135
ABBA01025204
XM_011533841
XM_011533840
AAHY01056756
AAHY01056758
AAHY01056757
AABR06032979
AABR06032980
AABR06032981
NT_022517
NW_921651
NW_001838877
AC_000046
CR599329
CR605352
CR609113
CR609454
CR622226
Q0QJH8
Q4W448
Q4W4C6
Q4W4C7
Q53EW1
Q6L9M1
Q86WD1
Q9UEF6
NT_039353
NW_001030811
Q4FJR2
Q6GU14
Q6TQE4
NW_047696
NW_001084832

Swiss-Prot ID PPARG_HUMAN
PPARG_MOUSE
PPARG_RAT
Q6GU14_MOUSE
Q4FJR2_MOUSE
D2KUA6_HUMAN

Cell Localization Nucleus
Cytoplasm

Ensembl ID ENSG00000132170
ENSP00000380196.2
ENST00000397000.6
ENSP00000380205.3
ENST00000397010.7
ENSP00000499004.1
ENST00000651826.1
ENSP00000287820.6
ENST00000287820.10
ENSP00000380207.2
ENST00000397012.7
ENSP00000498354.1
ENST00000650761.1
ENSMUSG00000000440
ENSMUSP00000131962.1
ENSMUST00000171644.7
ENSMUSP00000145525.1
ENSMUST00000203732.2
ENSMUSP00000000450.3
ENSMUST00000000450.4
ENSRNOG00000008839
ENSRNOP00000045012.3
ENSRNOT00000051858.5
ENSRNOP00000073235.1
ENSRNOT00000082969.1
ENSRNOP00000012137.3
ENSRNOT00000012137.5
ENSP00000380196.1
ENSP00000312472.6
ENST00000397000.5
ENSP00000380205.2
ENST00000397015.6
ENST00000309576.10
ENST00000643197.1
ENSP00000380210.2
ENSP00000495840.1
ENST00000397010.6
ENST00000397012.6
ENSRNOP00000045012
ENST00000287820
ENSMUSP00000000450
ENSP00000380196
ENST00000397000
ENSP00000312472
ENSRNOT00000051858
ENSMUST00000203732
ENSRNOT00000012137
ENSRNOT00000082969
ENSP00000380205
ENSMUST00000000450
ENST00000397015
ENSP00000287820
ENST00000397012
ENST00000397010
ENSP00000380207
ENST00000309576
ENSRNOP00000073235
ENSMUSP00000131962
ENSMUST00000171644
ENSRNOP00000012137
ENSMUSP00000145525
ENSP00000380210

MGI ID MGI:97747
97747

RGD ID 3371

Unigene ID Rn.23443
Mm.3020
Hs.162646
Hs.655798

Homologene ID 7899

Shape Stick-vertex

IPI ID IPI00020897
IPI00853091
IPI00926009
IPI00207539
IPI00231890
IPI00125193
IPI00266075
IPI00913931
IPI00797909
IPI00852773
IPI00791321
IPI00853034
IPI00853274
IPI00896034