Protein SMAD2

URN urn:agi-llid:4087
Total Entities 0
Connectivity 3420
Name SMAD2
Description SMAD family member 2
Notes The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Osteoarthritis
Immunoglobulin Class-Switch Recombination Activation
anti-Inflammatory Function of Macrophage M2 Lineage
Vascular Smooth Muscle Cell/Pericyte Differentiation and Proliferation
PRL Expression Regulation by BMP4 and TGFB1
Activin, Inhibin and Follistatin Action on Pituitary Gland
Cell Cycle Overiew
Cardiomyocyte Dysfunction
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
TGF-beta Signaling in Skin Aging
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Prolactinoma Overiew
Metastatic Colorectal Cancer
Peutz-Jeghers Syndrome
Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Hodgkin Lymphoma
Vascularization in Hepatocellular Carcinoma
NOTCH Signaling in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
STK11 Signaling in Pancreatic Neoplasms
TGFBR Signaling in Pancreatic Neoplasms
Osteoblast Function Decline in Gout
TGFB2 Signaling Impairement in Osteoarthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Skin Fibrosis
Hereditary Hemorrhagic Telangiectasia
Myostatin in Skeletal Muscles in Muscular Dystrophies
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Bone Loss in Osteoporosis
Hyperparathyroidism, Secondary Effect
Glioma Stem Cell Program Activation
Medulloblastoma
Proteins Involved in Breast Cancer Related to NOTCH Signaling Pathway
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
NOTCH1 Signaling in Breast Cancer
Proteins Involved in Female Infertility
Ovarian Cancer
INHA Gene Mutations in Granulosa Cell Proliferation
FSH Hyperproduction Due to INHA Mutation in Primary Ovarian Insufficiency
BMP Signaling Impairment in Granulosa Cell in POF
Prostate Cancer
Cytokines Trigger Otitis Media
Podocyte Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Proteins Involved in Cryptorchidism
BMP6/ACVR2A Expression Targets
BMP7/ACVR2 Expression Targets
Dexamethasone Induced Osteoporosis
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Skeletal Muscle Wasting in Cancer Cachexia
INHBB/ACVR2 Expression Target
INHBA/ACVR2/ACVR1 Expression Targets
NOTCH -> Expression Targets in Thymus
TGFBR/BMPR -> SMAD2/3 Signaling
ActivinR -> SMAD2/3 Signaling
TGFBR -> MEF/MYOD/MYOG Signaling
TGFBR1/AP-1 Signaling
MSTN/ACVR2/ACVR1 Expression Targets
NODAL/ACVR2B Expression Targets
TGF-beta Signaling
TGFB2-TGFBR1 Expression Targets
TGFB3-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
Elevated Receptors -> Expression Targets in Kidney
New Pathway
1_Differentiation of psoriatic T cells
3_TGFB signaling provokes endochondral ossification with osteophyte formation
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
2_Podocyte dysfunction in glomerulonephritis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
2_Cardiomyocyte hypertrophy
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Colorectal Cancer

MedScan ID 4087

LocusLink ID 4087
17126
29357
319898

Alias transcription factor Smad2
Mothers against DPP homolog 2
MGC34440
Mad-related protein 2
Smad2 transcription factor
Smad 2
JV18-1
Mothers against decapentaplegic, Drosophila, homolog of, 2
LOC654050
RIKEN cDNA 7120426M23 gene
mother against DPP homolog 2
MADR2
7120426M23Rik
hMAD II
Mothers against decapentaplegic, Drosophila, homolog of, II
MAD homolog 2 (Drosophila)
MAD (mothers against decapentaplegic, Drosophila) homolog II
hMAD IIs
MAD homolog II
MAD (mothers against decapentaplegic Drosophila) homolog 2
sma- and mad-related protein 2
JV18 I
Mothers against DPP homolog II
mMad2
MAD, mothers against decapentaplegic homolog 2 (Drosophila)
Madh2
SMAD, mothers against DPP homolog II
MAD (mothers against decapentaplegic homolog II
SMAD, mothers against DPP homolog 2
homolog of Drosophila Mothers against decapentaplegic,, 2
MGC22139
Mothers against decapentaplegic homolog II
MAD (mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2
JV18
Mad-related protein II
hMAD-2
MAD homolog 2
7120426M23
homolog of Drosophila Mothers against decapentaplegic,, II
LOC653804
MGC156656
hSMAD2
Smad-2

GO ID 0003677
0001228
0003700
0000981
0070411
0070412
0000978
0046332
0033613
0003682
0070410
0097718
0003690
0035326
0046872
0019902
0070878
0046982
0042803
0048156
0008134
0005160
0030618
0034713
0031625
0007183
0060395
0032924
0030325
0009952
0045165
0007182
0048701
0048617
0001706
0007369
0001701
0030073
0035556
0030324
0001707
0008285
0000122
0045892
0030512
0038092
0035265
0031016
0048340
0060039
0030513
0010718
1900224
0045944
0045893
0009791
0031053
0016579
0051098
0017015
0070723
0009749
0062009
0023019
0035019
0007179
0001657
0042060
0007352
0071141
0032444
0005737
0005829
0071144
0000790
0005654
0005634
0032991
0005667
0048589
0009880
0007492
0007507
0010629
0007389
0010628
0006468
0006355
0005622
0005623
0005515
0043234
0060021
0006351
0001077
0010467
0006366
0006367

KEGG ID hsa:4087
mmu:17126
rno:29357

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 18 51.42 cM
18 48.0 cM

OMIM ID 601366

Rat chromosome position 18q12.3

Hugo ID 6768
HGNC:6768

Human chromosome position 18q21.1

Swiss-Prot Accession Q15796
Q53XR6
B7Z5N5
Q15796.1
Q62432
Q62432.2
O70436
A0A0G2K0P2
O70436.1
Q6GU18
Q6VP00
Q9D8P6
A0JPM1

PIR ID S71797

GenBank ID NC_000018
NM_001003652
NP_001003652
NM_005901
NP_005892
NM_001135937
NP_001129409
XM_017025747
XP_016881236
XM_017025746
XP_016881235
XM_011525985
XP_011524287
XM_017025745
XP_016881234
XM_017025750
XP_016881239
XM_006722451
XP_006722514
XM_017025748
XP_016881237
XM_024451173
XP_024306941
XM_011525984
XP_011524286
XM_005258259
XP_005258316
XM_017025749
XP_016881238
NG_029946
AC026898
AC120349
AH006488
CH471096
EAW62914
EAW62915
EAW62916
EAW62917
AA081871
AA418737
AF027964
AAC51918
AI087928
AI453799
AI765747
AK126373
AK299218
BAH12971
AK312963
BAG35802
AY134745
AAN08619
BC014840
AAH14840
BC025699
AAH25699
BI258844
BQ018815
BQ900993
BT007422
AAP36090
BU167620
BU517178
BX491944
CR992221
DB035686
DB462454
DC371139
U59911
AAC50789
U65019
AAB17054
U68018
AAB17087
Q15796
NC_000084
XM_017317842
XP_017173331
NM_010754
NP_034884
XM_006525699
XP_006525762
NM_001252481
NP_001239410
NM_001311070
NP_001297999
AC107768
AC164009
CH466528
EDL09484
EDL09485
AF005743
AAB62269
AK007817
BAB25282
AK031111
AK078612
AK088249
BAC40236
AV232667
AY334552
AAR00933
BC021342
AAH21342
BC058713
BC089184
AAH89184
BM248478
BU058005
CN456711
U60530
AAB03612
Q62432
NC_005117
XM_006254945
XP_006255007
NM_001277450
NP_001264379
NM_019191
NP_062064
XM_006254946
XP_006255008
AC_000086
AABR07032580
AABR07032581
AAHX01096051
AAHX01096052
CH474069
EDL84731
EDL84732
EDL84733
EDL84734
AB010147
BAA81909
AB017912
BAA33453
AF056001
AAC12780
BC127497
AAI27498
FQ230791
O70436
DQ891501
U78733
U78732
DQ894693
XM_011525986
U78729
XM_011525983
U78726
XM_006525700
U78728
U78727
AAC39657
U78731
U78730
DQ893746
AABR06096004
AABR06096003
ABM84672
XP_011245156
AC_000040
ABM82427
AC_000150
AAHY01140355
XM_005258260
AAHY01140350
AMYH02034675
AAHY01140352
AMYH02034676
AAHY01140351
AAHY01140354
AAHY01140353
ABM84458
XP_006525763
AMYH02034674
NC_018929
XM_011246854
XP_005258317
ABM85619
XP_011524285
XP_011524288
ABBA01018627
ABBA01018626
DQ893532

Swiss-Prot ID SMAD2_HUMAN
SMAD2_MOUSE
SMAD2_RAT

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000175387
ENSP00000384449.1
ENST00000402690.6
ENSP00000349282.4
ENST00000356825.8
ENSP00000262160.6
ENST00000262160.11
ENSP00000466254.1
ENST00000587269.5
ENSMUSG00000024563
ENSMUSP00000025453.8
ENSMUST00000025453.14
ENSMUSP00000109563.2
ENSMUST00000113930.2
ENSMUSP00000130115.1
ENSMUST00000168423.8
ENSMUSP00000089439.6
ENSMUST00000091831.12
ENSRNOG00000018140
ENSRNOP00000048329.3
ENSRNOT00000046847.4
ENSRNOP00000075341.1
ENSRNOT00000092173.1
ENSRNOP00000071524.1
ENSRNOT00000089468.1
ENSMUST00000091831
ENSRNOP00000048329
ENSRNOP00000071524
ENST00000586040
ENSMUST00000168423
ENSP00000349282
ENSP00000262160
ENSMUST00000025453
ENSP00000384449
ENST00000262160
ENSRNOT00000046847
ENSRNOP00000075341
ENSRNOT00000089468
ENSMUSP00000025453
ENSP00000466193
ENSMUST00000168423.7
ENSMUSP00000130115
ENST00000356825
ENST00000402690
ENST00000262160.10
ENSRNOT00000092173
ENSMUSP00000089439

MGI ID MGI:108051
108051

RGD ID 3031

Unigene ID Hs.705764
Mm.152699
Hs.741342
Rn.2755
Hs.12253
Mm.490934

Homologene ID 21197

Shape O-vertex

IPI ID IPI00019548
IPI00458087
IPI00220364
IPI00198544
IPI00556692