Protein RAF1

URN urn:agi-llid:5894
Total Entities 0
Connectivity 4428
Name RAF1
Description v-raf-1 murine leukemia viral oncogene homolog 1
Notes This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Alzheimer's Disease
Osteoarthritis
Skin Aging
Oncogene Induced Cellular Senescence
Melatonin Effects on Circadian Cycle
mTOR Signaling
mTOR Signaling Hyperfunction
High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Insulin Influence on Protein Synthesis
Insulin Influence on Glycogenesis
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
CRH Secretion Regulation
Insulin Signaling
Prolactin Production
Thrombopoietin Receptors Signaling in Platelet Maturation
Aldosterone Renal Effects
Dectin-1 (CLEC7A) Signaling
DC-SIGN (CD209) Signaling
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
MC1R in anti-Inflammatory Signaling
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Nociception Expression Targets Signaling
Vascular Motility
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
DRD2 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
IL6 Expression Targets -> Nociception
Luteinizing Hormone in Oocyte Meiotic Resumption
Melatonin in Cell Survival and Antioxidant Response
Vitamine D Deficite and Dentin Formation
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
G0/G1 Phase Transition
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Aldosterone Signaling in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Proteins Involved in Pulmonary Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Contraction Due Vasospasm
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
Proteins Involved in Melanoma
IL22 Induces Keratinocyte Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
AGE Related Insulin Resistance in Skeletal Muscles
Adiponectin Synthesis Declines in Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hyperparathyroidism, Neonatal Severe
RET1 Mutation in Hyperparathyroidism
Hypothyrodism Associated Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
Metastatic Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Follicular Lymphoma
Hodgkin Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
TRPM7/8 in Pancreatic Adenocarcinoma
Il17 Signaling Related Neutrophilia in Asthma
Eosinophil Activation and Degranulation in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Proteins Involved in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
Dentin Formation Disruption
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Cowden Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Synaptic Exocytosis in Dementia
Glioblastoma, Primary
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Glioma Invasion Signaling
Proteins Involved in Glioma
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Clear Cell Ovarian Carcinoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
TRPM8 Effects in Prostate Cancer (Hypothesis)
Proteins Involved in Prostate Cancer
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
PGF2-alpha Effect on Treatment
Cytokines Trigger Otitis Media
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Polycystins Mutation Effects in Cystic Kidney Disease
Proteins Involved in Polycystic Kidney Disease
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Sertoli Cells Dysfunction Causes Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noreadrenaline/Gq Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
MTOR/TORC in Cancer Cell Motility and Invasion
CDH2 Activation Promotes Cancer Cell Migration and Survival
Lactate as a Signaling Molecule in Cancer Cells
Treg Cells Promote Immunosuppression in Cancer Immune Escape
EZH2 Methyltransferase Role in Cancer
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
AGER -> CREB/SP1 Signaling
NCAM1 -> CREB/ELK/SRF/MYC Signaling
CD19 -> JUN/ELK Signaling
PECAM -> SP1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
InsulinR -> ELK/SRF/SREBF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL6R -> CEBP/ELK/SRF Signaling
IL2R -> ELK/SRF/MYC Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL16 -> AP-1 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
LPA Expression Targets
Morphine Expression Targets
PGE1 Expression Targets
MTNR1 Signaling
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
EDN1 Expression Targets
IFNA1/Gq Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
MERTK Signaling
Ras Signaling
AMPK Signaling
AXL Receptor Tyrosine Kinase Signaling
mTOR Signaling
KRAS Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
ERK/MAPK Canonical Signaling
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
LTA Expression Targets
TNF -> AP-1 Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pathway 3
ace2
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Inflammation in keratinocytes in the pathology of acne
2_Hyperseborrhea in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Osteoblast-mediated bone demineralization
2_The role of endothelial cells in pyelonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
1_1_Insulin synthesis and secretion: insulin processing and storage
4_1_Insulin resistance: insulin signaling
3_Islet beta-cell destruction in T1D
1_Microangiopathy in diabetic neuropathy
2_1_General pathways of thyroid hormone signaling
public list
New Pathway
KRAS->RAFs->MAPK1/3
NRAS->RAFs->MAPK1/3
Other RASs-RAFs-MAPK1/3
mapk1
New Pathway
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Cowden Syndrome
Genes Associated with Syndromic Epilepsy

Source GO component
ResNet
curated

MedScan ID 5894

LocusLink ID 5894
110157
24703
19372
76876
30716
101411
106517
12906
104335
281441

Alias Raf I
sarcoma 3611 oncogene
6430402F14
v-raf-leukemia viral oncogene 1
murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
cRAF-1
C-Raf proto-oncogene, serine/threonine kinase
CMD1NN
RAS-GTP binding protein kinase
OTTMUSP00000022608
AA990557
KRAF_HUMAN
Raf kinases
Raf kinase
kinase Raf 1
murine sarcoma 3611 oncogene 1
Oncogene RAF1
RAF1
c-Raf
protein kinase Raf
rapidly-accelerated fibrosarcoma-1
Raf-1 proto-oncogene, serine/threonine kinase
OTTHUMP00000209389
v-raf-1 murine leukemia viral oncogene homolog 1
cRaf
murine sarcoma 3611 oncogene I
proto-oncogene c-RAF
v-raf-1 murine leukemia viral oncogene homolog I
MGC102375
cRAF1
Raf
proto oncogene proteins c raf
RAF-1
BB129353
Craf1 transforming gene
OTTHUMP00000207813
6430402F14Rik
c-Raf1
raf oncogene
raf proto-oncogene serine/threonine protein kinase
OTTMUSP00000022609
v-raf-1 leukemia viral oncogene 1
protein kinase raf I
rapidly-accelerated fibrosarcoma (Raf)-1
v-raf-1 murine leukemia viral oncogene-like protein 1
Oncogene RAF I
RIKEN cDNA 6430402F14 gene
Raf 1 kinase
v-Raf
v-raf-1 leukemia viral oncogene I
NS5
RAF proto-oncogene serine/threonine-protein kinase
D830050J10Rik
Craf1 transforming
v-raf-1 murine leukaemia viral oncogene homolog I
v-raf-1 murine leukaemia viral oncogene homolog 1
murine leukaemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
v-raf-leukaemia viral oncogene 1
v-raf-1 leukaemia viral oncogene I
v-raf-1 leukaemia viral oncogene 1
protein kinase raf 1
protein kinase raf-1
c-Raf-1
c-Raf-1 s
(RAF)
KRAF
(RAF1)
MIL
RAF1_HUMAN

EC Number 2.7.11.1
2.7.1.37
2.7.1.-

GO ID 0005524
0004709
0010856
0008179
0019899
0046872
0031434
0046982
0004672
0004674
0031267
0000165
0000186
0007190
0006915
0030154
0071550
0060324
0007507
0035773
0045104
0034220
0043066
0008285
0043154
1902042
0031333
0048011
0030168
0033138
0045944
0006468
0035023
0042981
0045595
2000145
0001666
0035994
0007165
0035019
0002223
0048538
0030878
0042060
0005794
0005737
0005829
0005741
0005739
0016607
0005886
0031143
0017016
0016301
0000166
0016740
0001678
0035556
0016310
0001934
0016020
0005634
0008283
0005057
0004697
0038095
0007265
0007411
0007596
0007173
0008543
0045087
0008286
0007264
0007268
0055085
0048010
0016772
0007010
0007243
0005622
0008152
0005626
0023034
0008270
0019992
0005515
0007242
0051726
0009987
0004713
0006829
0000074
0050875

KEGG ID hsa:5894
mmu:110157
rno:24703

MedLine Reference 16396499
12237340
3550433
1889815
8318738
6320371
15075335
15674327
3616625
7590978
11751906
8816460
15890671
12223526
15302887
11597136
10704835
8702721
9779826
12477808
15618521
8707830
3003687
10440867
15666389
8939988
9790773
10433554
12466851
10205168
1376319
8649829
9115221
8566003
12360521
11427728
12691824
11217851
12133899
2193291
7987303
11076861
12626521
17097642
9207797
16301319
10585452
11733498
8753867
15041731
1611909
8603510
16803888
11933072
9153224
2341153
12391160
8035810
12954639
7628630
16332724
16861903
12127063
8661054
9931261
11604401
15736129
15662129
8641130
15845549
8692945
1572642
15753127
15886202
16565089
8876196
9823899
17081983
8125298
12244094
11296228
11296227
7517401
16964381
9234708
15836771
2475255
9281368
2758403
8349614
15314064
2993863
6690719
11971957
16465392
16737746
16883571
1992343
16086581
14623285
9819434
12925535
14654844
15856007
8900182
9710607
14636584
16527894
10775035
12149272
9693046
12717443
1690378
16266749
8929531
7906967
8929532
10922068
12865432
7766599
15289381
7629107
10531364
15657590
10837247
9099670
16909118
9446616
10064593
17397260
1765007
8349631
10523642
17554210
11042159
16364920
12429936
8157000
8910675
7774940
16707572
2539530
10498616
9624170
1639773
15211515
16575407
11306563
17428866
8048167
15782199
17277048
7782277
11447113
16109975
9315742
1738193
17535812
15356004
9867809
8084603
14688025
8036007
8393135
10497893
10869570
17064357
8575777
10373531
1846778
10207156
17603483
17603482
15664191
15703070
8095010
12801936
9001246
7939632
8835546
11756411
8408024
8104057
1302014
12620389
7644510
9852579
1322500
3003402
16413928
15741175
9689060
7896292
10329666
10783161
11908948
15591313
6308607
8455932
10523633
9373149
11226259
11788587
17243098
16432225
7649477
12538354
12663662
15067053
9553107
2463463
15485920
11784866
8325640
16569214
8812432
9523700
8889548
8321321
15899852
9671314
9038343
17462920
12010819
11997508
15489334
14706453
16679305
1783381
2878803
8385802
12901876
6324342
8290278
7935384
15102471
16365167
12087097
12975377
8063729
1645445
11325826
8756332
11853019
9767153
1612588
17332776
7908202
9488663
16862215
16239230
12123723
16141073
7896277
16141072
15710605
7905852
10454553
15711535
8530446
9696043
10969079
15451031
7731720
12490852
12532330
15653554
16537381
8710867
11409918
11157055
11005817
16029117
11134016
14576068
10917603
8394352
3399964
12374792
2955285
15849194
11171046
15670823
11350735
8999914
9230211
8499946
7730360
1572667
15305288
7594541
8777726
16709817
8530057
12851216
10576742
16172610
70317
16508002
12612072
15122343
16924233
12843393
15601844
15975997
10620507
11044439
15467832
12477932
15470083
10349636
8911690
8334704
12551923
8340392
9091312
7588749
15925322
8621729
1346779
8034307
16945999
14712229
7587388
3692486
12438425
12682854
10486249
7477354
1679528
11948406
7791872

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Bos taurus

Mouse chromosome position 6 53.62 cM
6 52.5 cM

OMIM ID 164760
615916
611554
611553
OMIM:164760

Rat chromosome position 4q42

Hugo ID 9829
HGNC:9829

Human chromosome position 3p25.2
3p25

Swiss-Prot Accession L7RRS6
P04049
A0A0S2Z4L5
P04049.1
Q99N57
Q99N57.2
P11345
P11345.1
B0LPH8
B2R5N3
Q15278
Q9UC20
Q3UR68
Q58E75
Q91WH1
Q99N58
Q9QUU8
B4E0X2
R9PXU5
Q8VI85
Q99N73
Q9CU36
PASK_HUMAN
RAF1_RAT
RAF1_HUMAN
RAF1_MOUSE

PIR ID A00637
S60341
A26126

GenBank ID NC_000003
NR_148942
NR_148941
NR_148940
XR_001740227
NM_002880
NP_002871
XM_011533974
XP_011532276
XM_017006966
XP_016862455
NM_001354695
NP_001341624
NM_001354692
NP_001341621
NM_001354694
NP_001341623
NM_001354693
NP_001341622
NM_001354689
NP_001341618
NM_001354691
NP_001341620
NM_001354690
NP_001341619
NG_007467
AC018500
AC026170
AH002959
AAA60247
AX696362
CAD86886
AY271661
AAP03432
CH471055
EAW64134
EAW64135
EU332868
ABY87557
HI376400
CBX55729
JC006878
CDL93489
JX512459
AGC09606
KT585044
M38134
AK226028
AK303561
BAG64584
AK303920
BAG64848
AK312248
BAG35180
BC018119
AAH18119
BQ221862
BU683389
BX648063
DC342671
KU178297
ALQ33755
KU178298
ALQ33756
KU178299
ALQ33757
X03484
CAA27204
P04049
NC_000072
NM_029780
NP_084056
XM_006505363
XP_006505426
XM_006505365
XP_006505428
XM_006505364
XP_006505427
NM_001356333
NM_001356334
AB077821
AC160032
CH466523
EDK99533
EDK99534
EDK99535
JC006876
CDL93488
X55432
AB052739
BAB39527
AB057655
BAB39748
AB057663
BAB39743
AB077145
BAB83675
AK018272
BAB31142
AK036317
AK141745
BAE24820
AK148327
AK189599
AK190457
AK191593
AK193756
AK193894
AK199760
AK205887
AK215463
BC015273
AAH15273
BC056439
BC092040
AAH92040
BF455519
Q99N57
NC_005103
NM_012639
NP_036771
XM_008763217
XP_008761439
XM_008763218
XP_008761440
AC_000072
AABR07073061
AAHX01032457
AAHX01032458
AC094445
CH473964
EDM02147
EDM02148
EDM02149
BC062071
AAH62071
M15427
AAA42001
P11345
XM_005265359
XP_005265416
XM_005265358
XP_005265415
XM_011533975
XP_011532277
XM_005265357
XP_005265414
XM_005265355
XP_005265412
XM_005265360
XP_005265417
NC_018914
AMYH02006294
L00206
L00207
L00208
L00209
L00210
L00211
L00212
M11376
AC_000028
AAHY01056762
AAHY01056763
AAHY01056764
AC_000135
ABBA01025197
ABBA01025198
ABBA01025199
ABBA01025200
XM_005265356
XP_005265413
AABR06032993
AABR06032994
AABR06032995
XM_003749820
XP_003749868
NT_022517
NW_001838877
NW_921651
AC_000046
CR598160
CR608506
CR609564
CR616511
CR617502
NT_039353
NW_001030811
Q8VI85
Q99N73
Q9CU36
NW_001084832
NW_047696
Q58E75
33991673
81867258
AB100685
148667118
148667119
148667117
Q7ZTR8
50896407
206547
119584539
119584538
40363564
81903918
M15428
AA990557
Q3UR68
AAA42002
51464027
206546
206545
206544
BG085782
BB129353
BC054662
26085159
CAA57035
496091
18497289
Q76I87
NW_000264
AB095292
18497290
6981458
34190937
30409368
81882448
13429987
74706531
Q90458
51464120
125653
NT_094510
BAD11990
13429988
51717211
NP_571514
AB116254
125651
13383316
13383317
NW_001512500
NT_086636
NC_007134
BG073005
74202437
34858854
82241273
149049693
149049695
35841
149049694
35842
AK142706
41224402
534977
Q99N58
4506401
18150195
18150196
44885322
82239922
38303884
Q15278
38303885
30016945
30016944
Q6BE22
27884315
BAC76320
Q7ZZW3
18157433
18157434
12857903
12857902
AB104854
NM_131439
X81128
81903252
BAD08233
62024525
34098686
15929695
17390263
52486392
15929694
Q76FQ3
82235645
BAC55895
82216957
190837
40254798
BAD06254
BAD34647
82132302
66762
82093361
AB098701
AB098700
BC045925
81867927
123788363

Swiss-Prot ID RAF1_HUMAN
RAF1_MOUSE
RAF1_RAT

Cell Localization Cytoplasm
Cell membrane
Mitochondrion
Nucleus
Mitochondria

Ensembl ID ENSG00000132155
ENSP00000401888.2
ENST00000442415.6
ENSP00000251849.4
ENST00000251849.8
ENSP00000398591.2
ENST00000432427.2
ENSMUSG00000000441
ENSMUSP00000000451.7
ENSMUST00000000451.13
ENSMUSP00000108571.1
ENSMUST00000112949.7
ENSRNOG00000010153
ENSRNOP00000013831.5
ENSRNOT00000013831.6
ENSP00000251849
ENST00000251849
ENSP00000398591
ENST00000432427
ENSMUSP00000000451
ENSMUST00000000451
ENSMUSP00000108571
ENSMUST00000112949
ENSRNOP00000013831
ENSRNOT00000013831

MGI ID MGI:97847
97847
1924126
2141729
2146790
1277195

RGD ID 3531

Unigene ID Hs.159130
Mm.184163
Rn.33262
Dr.75082
Hs.257266
Dr.122213
Mm.347772

Homologene ID 48145

Shape Sickle-vertex

IPI ID IPI00021786
IPI00900312
IPI00193150
IPI00118101
IPI00830899
IPI00788857
IPI00789533
IPI00792701
IPI00793356

Microarray ID 94264_at

Homo sapiens Chromosome position 3p25

Ensembl Transcript ID ENST00000251849

ENSEMBL ENSG00000132155

FunctionalClass protein kinase
protein heterodimerization
zinc ion binding
mitogen-activated protein kinase kinase binding
metal ion binding
nucleotide binding
MAP kinase kinase kinase
receptor signaling protein
diacylglycerol binding
kinase
protein binding
protein-tyrosine kinase
protein serine/threonine kinase
transferase
ATP binding

Hugo Symbol RAF1

Bos taurus Chromosome position 22

Mus musculus Chromosome position 6 52.5 cM
6

KEGG pathway Renal cell carcinoma
Gap junction
Chronic myeloid leukemia
Non-small cell lung cancer
Pancreatic cancer
Colorectal cancer
MAPK signaling pathway
VEGF signaling pathway
Melanoma
Insulin signaling pathway
Prostate cancer
Melanogenesis
Natural killer cell mediated cytotoxicity
Focal adhesion
Long-term potentiation
Regulation of actin cytoskeleton
Dorso-ventral axis formation
ErbB signaling pathway
Glioma
Endometrial cancer
GnRH signaling pathway
Long-term depression
Fc epsilon RI signaling pathway

ProteinAtlas SubcellularLocation Main location: Nucleus but not nucleoli; Other location: ; Expression type: Staining; Reliability: Non-supportive

Rattus norvegicus Chromosome position 4q42

Ensembl Gene ID ENSG00000132155

ProteinAtlas NormalTissue Tissue: hippocampus; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: thyroid gland; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: salivary gland; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: bile duct cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: Leydig cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: non-germinal center cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: rectum; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: hepatocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: lung; Cell type: macrophages; Level: Low; Expression type: APE; Reliability: Low
Tissue: lung; Cell type: pneumocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: adrenal gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: appendix; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: appendix; Cell type: lymphoid tissue; Level: Low; Expression type: APE; Reliability: Low
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: breast; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cerebellum; Cell type: cells in granular layer; Level: Medium; Expression type: APE; Reliability: Low
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Low; Expression type: APE; Reliability: Low
Tissue: cerebellum; Cell type: Purkinje cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: cerebral cortex; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cervix, uterine; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: colon; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: duodenum; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: epididymis; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: fallopian tube; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: gall bladder; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: heart muscle; Cell type: myocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: hippocampus; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: hippocampus; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: kidney; Cell type: cells in glomeruli; Level: Low; Expression type: APE; Reliability: Low
Tissue: kidney; Cell type: cells in tubules; Level: Low; Expression type: APE; Reliability: Low
Tissue: lateral ventricle; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: liver; Cell type: bile duct cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: lymph node; Cell type: germinal center cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: lymph node; Cell type: non-germinal center cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: ovary; Cell type: follicle cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: ovary; Cell type: ovarian stroma cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: pancreas; Cell type: islets of Langerhans; Level: Low; Expression type: APE; Reliability: Low
Tissue: parathyroid gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: placenta; Cell type: decidual cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: placenta; Cell type: trophoblastic cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: prostate; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: rectum; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: salivary gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: seminal vesicle; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: skeletal muscle; Cell type: myocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: skin; Cell type: epidermal cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: small intestine; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: spleen; Cell type: cells in red pulp; Level: Low; Expression type: APE; Reliability: Low
Tissue: spleen; Cell type: cells in white pulp; Level: Low; Expression type: APE; Reliability: Low
Tissue: stomach, lower; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: stomach, upper; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Low; Expression type: APE; Reliability: Low
Tissue: testis; Cell type: Leydig cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: thyroid gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: tonsil; Cell type: germinal center cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: tonsil; Cell type: non-germinal center cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: urinary bladder; Cell type: urothelial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Low; Expression type: APE; Reliability: Low
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Low; Expression type: APE; Reliability: Low
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: vagina; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Low; Expression type: APE; Reliability: Low

LocatorString pmquery:egfr+transactivation