Protein CXCL2

URN urn:agi-llid:2920
Total Entities 0
Connectivity 2777
Name CXCL2
Description chemokine (C-X-C motif) ligand 2
Notes This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Primary Cell Localization Extracellular
Class Ligand

Pathway CXC Chemokine Receptor Signaling
Toll-like Receptor Independent Sterile Inflammation
Neutrophil Chemotaxis
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Proteins Involved in Myocarditis
IL17 Signaling in Psoriasis
Neutrophil Recruitment in Sinovium in Gout
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Chronic Bronchitis
Proteins Involved in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
HMGB1 Expression Targets
CXCL6 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CSF2 -> NF-kB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
TAM Receptor Signaling Activation in Cancer
Fibronectin Expression Targets
ICAM1 Expression Targets
IL15 Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
P2RX7 -> Expression Targets in Nerve Tissue
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
AGT -> CREB Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNF -> CREB Expression Targets
TLR5 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
ROS in Triggering Vascular Inflammation
pathway 3
e
pathway 4
New Pathway (2)
pprarg neg, uknown targets, ps-positive
comon ps_pos, pprarg_neg targets
New Pathway (4)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_The role of endothelial cells in pyelonephritis
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 2920

LocusLink ID 2920
14825
81503

Alias secretory protein N51
GRO2 oncogene
CXC ligand 2
small inducible cytokine subfamily member II
MI2A_HUMAN
MIP2-alpha
C-X-C motif chemokine 2
chemokine CXCL2
macrophage-inhibitory protein-2
CXCL2
platelet-derived growth factor-inducible protein KC
CINC-2a
GROB
macrophage inflammatory protein-2-alpha
growth regulated protein beta
melanoma growth stimulatory activity beta
chemokine (C-X-C motif) ligand 2
MGSA beta
Scyb
macrophage-inhibitory protein-2 alpha
MIP2
MGSA-b
small inducible cytokine B2
Gro-beta
chemokine (C-X-C motif) ligand II
small inducible cytokine subfamily member 2
LOC133087
CXCL2 chemokine
chemokine CXC ligand 2
SCYB2
GRO2
CXC chemokine ligand 2
growth-regulated protein beta
MIP2A
MIP-2a
macrophage inflammatory protein 2-alpha
KC
Fsp
N51
gro
Gro1
Mgsa
Scyb1
C-X-C motif chemokine 1
GRO1 oncogene
KC/GR)-alpha
KC/GRO-alpha
alpha-chemokine
growth-regulated alpha protein
CINC-1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
cytokine-induced neutrophil chemoattractant 1

GO ID 0008009
0007186
0061844
0071222
0070098
0006935
0019221
0006955
0006954
0030595
0030593
0002237
0005576
0005615
0005125
0008083
0002526
0006952
0007204
1902035
0070965
0043268
0010765
0032930
0060326
0010469
0001975
0032355
0010332
0051384
0009408
0032496
0005623
0045236
0090023
0042127
0005829
0002690

KEGG ID hsa:2920
mmu:14825
rno:81503

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 5 44.78 cM

OMIM ID 139110

Rat chromosome position 14p22

Hugo ID 4603
HGNC:4603

Human chromosome position 4q13.3
4q21

Swiss-Prot Accession A0A024RDD9
P19875
P19875.1
A2RTH0
P12850
P12850.1
P14095
P14095.2
Q6FGD6
Q9UPB8

PIR ID JH0281
A32954
JN0572

GenBank ID NC_000004
NM_002089
NP_002080
AC093677
CH471057
EAX05700
EAX05701
M65006
AAP13104
U03019
AAA03453
AF043340
AAC03540
AK308504
BC015753
AAH15753
BC053653
BX334969
CR542171
CAG46968
M36820
AAA63183
M57731
AAA63182
X53799
CAA37808
P19875
NC_000071
NM_008176
NP_032202
AC157938
AH003603
AAB03376
CH466617
EDL05301
KX832958
S79767
AAP32036
AF352782
AK140312
BC037997
AAH37997
BC132502
AAI32503
BC132504
AAI32505
BQ031102
BY335927
J04596
AAA40131
P12850
NC_005113
NM_030845
NP_110472
AC_000082
AAHX01078373
AC108576
CH474060
EDL88575
D11445
BAA02009
D11444
BAA02008
M86536
AAA42053
P14095
NC_018915
AMYH02009474
AC_000027
AAHY01046755
U20527
U20634
AC_000136
ABBA01022994

Swiss-Prot ID CXCL2_HUMAN
GROA_MOUSE
GROA_RAT

Cell Localization Secreted

Ensembl ID ENSG00000081041
ENSP00000427279.1
ENST00000508487.3
ENSMUSG00000029380
ENSMUSP00000031327.8
ENSMUST00000031327.8
ENSRNOG00000002802
ENSRNOP00000003778.2
ENSRNOT00000003778.3
ENSP00000427279
ENST00000508487
ENSMUSP00000031327
ENSMUST00000031327
ENSRNOP00000003778
ENSRNOT00000003778

MGI ID MGI:108068

RGD ID 619869

Unigene ID Hs.75765
Mm.21013
Rn.10907

Homologene ID 105490

Shape Rhomb