Protein TNFRSF1A

URN urn:agi-llid:7132
Total Entities 0
Connectivity 4233
Name TNFRSF1A
Description tumor necrosis factor receptor superfamily, member 1A
Notes This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Alzheimer's Disease
Osteoarthritis
Skin Aging
MTHFR Activity Regulation
mTOR Signaling Hyperfunction
TLR4 Signaling in Leukocytes
Peripheral T-Cell Tolerance
T-Cell Cytotoxic Mediated Cell Death
Necrosis
Leukotriene Effect on Vascular Endothelial Cell Response
Eosinophil Survival by Cytokine Signaling
Macrophage M1 Lineage
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
Apoptosis
Proteins Involved in Atherosclerosis
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Myocardial Infarction
Proteins Involved in Myocarditis
Apoptosis of Myocyte
SOCS in Negative Feedback Regulation in Myocarditis
Inflammatory Reaction in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Oxidative Stress in Vitiligo
Vitiligo
Toll-like Receptors in beta-Cell
Podocyte Dysfunction in Diabetic Nephropathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Adipose Tissue Inflammation Provokes Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Crohn's Disease
Macrophage Dysfunction
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Splenic Marginal Zone Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
Multiple Myeloma
TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
Goblet-Cell Related Mucus Secretion in Asthma
Proteins Involved in Cystic Fibrosis
Airway Epithelial Cell Dysfunction
Neutrophil Recruitment in Sinovium in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
Dendritic Cell Dysfunction in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
Skin Fibrosis
Dentin and Enamel Dysruprion in Bloch-Sulzberger Syndrome
Apoptosis Block in Infected Cells
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
TNF Receptor Associated Periodic Syndrome
Osteoclast Activation in Postmenopause
Neurofibrillary Tangle Formation
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Glioblastoma, Mesenchymal Subtype
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
Proteins Involved in Endometriosis
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV Infection and Cancer
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
OPTN Effects on NF-kB Signaling in Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Alveolar Epithelial Cell Apoptosis in COPD
Alveolar Macrophages Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins Involved in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
Dopamine/Gs Expression Targets
Dopamine/Gi Expression Targets
Elevated Receptors -> Expression Targets in Aorta
CXCL12 Expression Targets
FSHR Expression Targets
NFKB Canonical Signaling Activation in Cancer
NFKB Non-Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
IFNG/IFNR Expression Targets
IL2 Expression Targets
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
CD40 -> Expression Targets in Thymus
CD40 -> Expression Targets in Lymph Node
CSF1 -> STAT Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
TNF-alpha/TNFRSF1A Signaling
Ras-GAP Regulation Signaling
NF-kB non-Canonical Signaling
NF-kB Canonical Signaling
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
LTA Expression Targets
TNF -> AP-1 Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> STAT Expression Targets
TNF -> TP53/ATF Expression Targets
TNFRSF1A -> STAT Signaling
TNFR -> NF-kB Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
IL1B -> NO Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B Expression Targets
IL1A Expression Targets
Model of PPARG signaling in psoriasis
1_Inflammation in keratinocytes in the pathology of acne
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Chondrocyte death in osteoarthritis
3_The role of interstitial fibroblasts in pyelonephritis
2_Podocyte dysfunction in glomerulonephritis
2_Pathogens stimulate mucins expression in the middle ear
2_Cardiomyocyte hypertrophy
2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
4_1_Polymorphisms associated with inflammatory bowel diseases
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
2_HIV - induced depletion of CD4+ T-cells
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
2_Ion channel CFTR failure in cystic fibrosis airway epithelium (class III-IV mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Neuron and Schwann cell death
drug-target molsynthesis
Differentiation of psoriatic T cells

Group Genes Associated with Systemic Lupus Erythematosus

MedScan ID 7132

LocusLink ID 7132
21937
25625

Alias tumor necrosis factor TNF receptors
Tnfrh3
TNF-alphaR1
TBPI
TNFRp55
tumor necrosis factor receptor 1A isoform beta
tumor necrosis factor receptor 1
TRAPS gene
CD120a antigen
TNF-R-I
LOC113298
tumor necrosis factor TNF receptor
TNF receptor alpha chain
TNF receptor 1
tumor necrosis factor receptor type I
MGC19588
LOC116290
TR1A
GNB:339760
TR1A_HUMAN
TNFRI
TNF-R55
TNFAR
TNFR60
TNFRSF1A
TNFR1-d2
CD120A
MGC105478
TNFR55
OTTMUSP00000028139
TNF receptor 1A
TNF receptor superfamily member 1A
Familial periodic fever (Hibernian fever) gene
tumor necrosis factor-alpha receptor
TNFR1
TNF-R
TNF receptors
tumor necrosis factor receptor superfamily, member 1A
TNF-RI
TNFR I
TNF-R1
TNF receptor homolog 3
Tumor necrosis factor binding protein 1
Tumor necrosis factor binding protein I
tumor necrosis factor receptor 1 (55kD)
tumor necrosis factor, alpha receptors
TNF receptor
p55-R
TNF receptor homolog III
FPF
p55
p60
TBP1
TNFR-I
tumor necrosis factor receptor type 1
tumor necrosis factor receptor superfamily member 1A
Tnfr-2
TNFalpha-R1
TNF-alpha-R1
TNFR-1
tumour necrosis factor receptor 1 (55kD)
tumour necrosis factor receptor 1A isoform beta
tumour necrosis factor receptor superfamily, member 1A
tumour necrosis factor binding protein 1
tumour necrosis factor, alpha receptors
tumour necrosis factor receptor type I
tumour necrosis factor TNF receptors
tumour necrosis factor receptor 1
tumour necrosis factor binding protein I
tumour necrosis factor TNF receptor
tumour necrosis factor-alpha receptor
MS5
TRAPS
Tumor necrosis factor receptor 1 precursor
TNF-R1s
TNFR60s
TNFR55s
Tnfrh3s

GO ID 0043120
0005031
0007249
0003176
0071260
0019221
0071550
0042742
0008625
0006954
0008630
0010614
0003332
0050728
0043123
1902339
2000304
0050729
0045944
0042531
0006693
0072659
0003177
1903140
0010803
0033209
0016032
0000139
0009986
0005576
0005615
0005887
0016020
0045121
0005739
0005886
0043235
0002947
0002020
0044877
0006915
0007166
0006952
0043066
0010629
0032715
0045766
0010628
0043525
0032760
0051291
0042981
0007165
0005794
0030424
0005829
0016021
0005634
0032991
0045202
0071392
0043279
0043200
0045471
0001666
0032496
0009611
0090002
0006955
0042511
0042127
0032403
0007275
0033160
0043234
0033013
0097190
0012501
0005622
0016101
0009812
0019048
0008624
0004872
0044419
0005515

KEGG ID hsa:7132
mmu:21937
rno:25625

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6 59.32 cM
6 60.55 cM

OMIM ID 191190
614810
142680

Rat chromosome position 4q42

Hugo ID 11916
HGNC:11916

Human chromosome position 12p13.31
12p13.2

Swiss-Prot Accession P19438
J9PH39
P19438.1
P25118
Q3U479
P25118.1
P22934
P22934.2
A8K4X3
B2RDE4
B3KPQ1
B4DQB7
B4E309
B5M0B5
D3DUR1
Q9UCA4
Q5U1X6
Q91V30
Q91Y93
Q6Y4Q7
Q3TVS9
Q4VAE0
Q6QHF0
Q6QHF1

PIR ID A38208
A38634
B36555

GenBank ID NC_000012
NR_144351
NM_001065
NP_001056
NM_001346091
NP_001333020
NM_001346092
NP_001333021
NG_007506
AC006057
AF047488
AH003016
AAA61201
AY131997
AAM77802
CH471116
EAW88805
EAW88806
CS068582
CAI84622
JA362584
CCA94574
KF455591
X69810
A21522
CAA01558
AK056611
BAG51763
AK130807
AK291088
BAF83777
AK298729
BAG60879
AK304517
BAG65321
AK308061
AK315509
BAG37891
AY182755
AAO23979
BC010140
AAH10140
BF528949
DA010826
DA664652
EU927389
ACH57451
JN172914
AEO89726
M33294
AAA03210
M58286
AAA36753
M60275
AAA36756
M63121
AAA36754
P19438
NC_000072
NM_011609
NP_035739
AC140324
AH002101
AAA40465
CH466523
EDK99828
L04800
S52703
AK154388
BAE32554
AK159989
BAE35539
AK178992
AK181159
AK181531
AK190321
AK206708
AK206824
AK207044
AK211886
AY541589
AAS48428
AY541590
AAS48429
BC004599
AAH04599
BC052675
AAH52675
BC096429
AAH96429
CK624043
L26349
AAA59361
M59377
AAA40464
M60468
AAA39751
X57796
CAA40936
X59238
CAA41922
P25118
NC_005103
XM_006237334
XP_006237396
NM_013091
NP_037223
AC_000072
AABR07062033
AAHX01032867
CH473964
EDM01847
AF329976
AAK53562
AF329977
AAK53563
AF329978
AAK53564
AF329979
AAK53565
AF329980
AAK53566
AF329981
AAK53567
BC086413
AAH86413
M63122
AAA42256
P22934
NC_018923
AMYH02025949
M75864
M75865
M75866
EU176385
ABW03836
EU176726
ABW03527
AC_000028
AAHY01057259
AAHY01057260
M76655
M76656
M88067
AC_000144
ABBA01017638
XM_005253758
XP_005253815
XM_005253759
XP_005253816
AABR06033524
NT_009759
NW_925295
NW_001838050
AC_000055
CR593985
CR596841
CR597821
CR606215
CR622520
Q6Y4Q7
NT_039353
NW_001030811
Q3TVS9
Q3U479
Q4VAE0
Q6QHF0
Q6QHF1
NW_001084832
NW_047696

Swiss-Prot ID TNR1A_HUMAN
TNR1A_MOUSE
TNR1A_RAT
Q3U479_MOUSE

Cell Localization Cell membrane
Golgi apparatus membrane
Secreted
Plasma membrane
Membrane

Ensembl ID ENSG00000067182
ENSP00000162749.2
ENST00000162749.6
ENST00000534885.5
ENSMUSG00000030341
ENSMUSP00000032491.8
ENSMUST00000032491.14
ENSRNOG00000031312
ENSRNOP00000042371.2
ENSRNOT00000048529.4
ENSP00000162749
ENST00000162749
ENSMUSP00000032491
ENSMUST00000032491
ENSRNOP00000042371
ENSRNOT00000048529

MGI ID MGI:1314884
1314884

RGD ID 621237

Unigene ID Hs.279594
Hs.713833
Mm.1258
Mm.474976
Rn.11119

Homologene ID 828

Shape Stick-vertex

IPI ID IPI00212001
IPI00018880
IPI00795875
IPI00929211
IPI00317228
IPI00796532
IPI00794282
IPI00607905
IPI00856824
IPI00886384
IPI00857089
IPI00568944