Protein GATA3

URN urn:agi-llid:2625
Total Entities 0
Connectivity 3021
Name GATA3
Description GATA binding protein 3
Notes This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway T-Cell Maturation (Hypothesis)
Th2-Cell Differentiation
Acute Phase in Atopic Dermatitis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Th2-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Immune System Activation in Hyperthyroidism
Proteins Involved in Hypoparathyroidism
Hypoparathyroidism, Primary
CD4+T-Cell Response in Celiac Disease
B-Cell Activation in Crohn's Disease
Th2-Cell Function in Ulcerative Colitis
Hodgkin Lymphoma
Hodgkin and Reed-Sternberg Cells Reprogramming
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Pancreatic Cancer
Th2-Cell Response in Asthma
Th2-Cells Function in Systemic Scleroderma
Proteins with Altered Expression in Systemic Scleroderma
CD4+ T-Cell Function Decline in HIV
Gluten Impact on Neuronal System (Hypothesis)
PHOX2B Effects in Neuroblastoma
Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Endometriosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Hearing Loss
IL15 Expression Targets
CD40 -> Expression Targets in Thymus
NOTCH -> Expression Targets in Thymus
NOTCH Receptors -> Receptors Expression Targets in Lung
TCR -> NF-kB Expression Targets
TCR -> NFAT Expression Targets
PPAR Psoriasis
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
1_Th2 cell response in asthma
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Hypoparathyroidism
Genes with Mutations Associated with Breast Cancer

MedScan ID 2625

LocusLink ID 2625
14462
85471

Alias OTTHUMP00000019071
RP23-276D17.1
OTTHUMP00000019070
transcription factor GATA3
MGC5445
Hypoparathyroidism, sensorineural deafness, renal dysplasia gene
GATA binding protein-3
GATA-binding protein 3
GATA binding protein 3
GATA 3 transcription factor
GATA-binding protein-3
GATA3
OTTMUSP00000011932
MGC5199
GATA-binding factor 3
GATA binding protein III
Trans-acting T-cell specific transcription factor GATA-3
MGC2346
Trans-acting T-cell specific transcription factor GATA III
HDR
HDRS
trans-acting T-cell-specific transcription factor GATA-3
jal
Gata-3

GO ID 0003677
0001228
0003700
0000981
0001227
0070888
0071837
0000978
0001158
0005134
0000987
0003713
0008134
0044212
0000976
0008270
0050852
0045064
0031929
0048646
0009653
0003180
0007411
0007596
0061290
0003215
0001709
0048469
0071773
0035457
0071353
0071356
0006338
0090102
0019221
0006952
0048589
0043583
0035162
0048568
0030218
0006959
0002520
0001701
0045087
0042472
0072643
0072602
0001822
0002088
0072676
0008584
0060374
0060231
0001823
1901536
0045786
2000146
0008285
2000607
2000352
0045599
2000703
2000734
0050728
0032689
0032703
0033600
0000122
0045892
0072179
0072178
0001764
0042421
0071599
0060017
0035898
0060037
0014065
0045582
2000553
0010595
0071442
2000617
2000667
0032753
2000664
0051897
0009967
2000611
0045944
2000679
0045893
0072107
0009791
0002572
0016579
0043370
2000683
0042035
0030856
2000114
1902036
0061085
0051569
0072182
0043523
0010975
0043627
0045471
0010332
0009615
0007165
0048485
0045061
0048538
0006366
0001806
0035799
0072197
0060676
0060065
0003281
0000790
0005654
0005634
0000977
0046872
0043565
0003712
0030217
0033077
0001775
0000902
0071345
0048872
0002376
0010629
0007399
0030182
0045597
0001819
0010628
0032736
0032754
0006357
0006355
0042493
0007507
0072001
0009887
0009888
0045165
0006351
0001077
0001076
0048565
0001078
0001046
0048468
0000979
0001085
0003682
0001071
0005730
0005667
0005623
0005622
0010552
0016563
0043193

KEGG ID hsa:2625
mmu:14462
rno:85471

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 2 6.69 cM
2 7.0 cM

OMIM ID 131320
146255

Rat chromosome position 17q12.3

Hugo ID 4172
HGNC:4172

Human chromosome position 10p14
10p15

Swiss-Prot Accession P23771
P23771.1
P23772
Q3U0R5
P23772.1
Q99NH5
Q5VWG7
Q5VWG8
Q96J16
Q3TZD6
Q3TZS0
Q3U223

PIR ID A39794
B39794

GenBank ID NC_000010
XM_005252443
XP_005252500
XM_005252442
XP_005252499
NM_001002295
NP_001002295
NM_002051
NP_002042
NG_015859
AL390294
AY497006
AAR32096
CH471072
EAW86367
EAW86368
FB571433
CAR95134
FB571435
CAR95135
HI179114
CBX53865
HI179116
CBX53866
JC009146
CDL93507
KT583933
X73519
AI024501
AI686327
AK298213
BAG60483
BC003070
AAH03070
BC006793
AAH06793
BC006839
BG287052
BM152193
M69106
AAA35870
X55037
CAA38877
X55122
CAA38916
X58072
CAA41102
P23771
NC_000068
XM_006497355
XP_006497418
NM_008091
NP_032117
XM_006497354
XP_006497417
NM_001355110
NM_001355111
NM_001355112
AH015706
AH015707
AL845529
AL928704
CH466542
EDL07996
X73520
Z33620
AA759391
AK053728
AK090089
AK155549
BAE33319
AK156634
BAE33786
AK157625
BAE34137
AK157939
BAE34273
AK161099
BC062915
AAH62915
X55123
CAA38917
P23772
NC_005116
XM_017600666
XP_017456155
XM_008771894
XP_008770116
XM_006254253
XP_006254315
XM_017600667
XP_017456156
XM_008771893
XP_008770115
NM_133293
NP_579827
AC_000085
AABR07028502
AAHX01092527
AAHX01092528
AAHX01092529
CH473990
EDL78630
AB000217
AY024364
AAK00586
NC_018921
AMYH02022091
AM392571
CAL37449
AM392688
CAL37566
XM_006497353
XP_006497416
XM_006497356
XP_006497419
AC_000024
AAHY01013856
DQ400110
ABD66080
DQ400111
DQ400112
DQ400113
DQ400115
DQ400118
ABD66081
DQ400119
DQ400120
DQ400121
DQ400123
AC_000142
ABBA01034729
XM_006254255
XP_006254317
XM_006254254
XP_006254316
AABR06092817
AABR06092818
CAH73143
CAH73144
CAM19357
CAM19358
NT_008705
NW_924584
NW_001837931
AC_000053
NT_039202
NW_001030686
Q3TZD6
Q3TZS0
Q3U0R5
Q3U223
NW_047492
NW_001084730
Q99NH5

Swiss-Prot ID GATA3_HUMAN
GATA3_MOUSE
Q3U0R5_MOUSE
Q99NH5_RAT
Q5VWG7_HUMAN
Q5VWG8_HUMAN

Cell Localization Nucleus

Ensembl ID ENSG00000107485
ENSP00000368632.3
ENST00000379328.9
ENSP00000341619.3
ENST00000346208.4
ENSMUSG00000015619
ENSMUSP00000100041.3
ENSMUST00000102976.3
ENSRNOG00000019336
ENSRNOP00000026187.3
ENSRNOT00000026187.5
ENST00000379328.8
ENSP00000368632
ENST00000379328
ENSP00000341619
ENST00000346208
ENSMUSP00000100041
ENSMUST00000102976
ENSRNOP00000026187
ENSRNOT00000026187

MGI ID MGI:95663
95663

RGD ID 621250

Unigene ID Hs.524134
Mm.313866
Rn.229174
Rn.92350

Homologene ID 1550

Shape O-vertex

IPI ID IPI00012901
IPI00216199
IPI00135883
IPI00198958
IPI00756271