Protein PDPK1

URN urn:agi-llid:5170
Total Entities 0
Connectivity 2441
Name PDPK1
Description 3-phosphoinositide dependent protein kinase 1
Notes may catalyze the phosphorylation and activation of protein kinase B [RGD, Feb 2006]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Osteoarthritis
Oncogene Induced Cellular Senescence
MTHFR Activity Regulation
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Insulin Influence on Protein Synthesis
Insulin Influence on Glycogenesis
Insulin Influence on Lipogenesis
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Insulin Signaling
Thrombopoietin Receptors Signaling in Platelet Maturation
LH and FSH Signaling and Steroidogenesis
Toll-like Receptors Act through MYD88-TIRAP Signaling
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Peripheral T-Cell Tolerance
T-Cell Positive Selection and Neglect Induced Death
T-Cell Central Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
TAM Receptors in Platelet Aggregation
Platelet Activation via Adhesion Molecules
Scavenger Receptors in Platelet Aggregation
Proplatelet Maturation
Bradykinin Effects in Inflammation
Platelet Activation via GPCR Signaling
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Eicosanoids in Myeloid Cell Activation
Histamine Receptor H3 Signaling in Neurons
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
VEGFA/NOTCH1/WNT Cross-talk in Blood Vessel Sprouting and Branching in Cancer
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Lipogenesis Regulation in Adipocyte
Synaptic Potentiation by PKMZ in LTP Maintenance - Active State
Potassium Flux Regulation
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
Sodium Flux Regulation
Vascular Motility
Ca2+ Flux Regulation
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
BDKRB1/2 -> Vasodilation
BDKRB1/2 -> Interleukins Production
CNR1/2 -> Membrane Transport
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD2 -> TRPC1 Transcription
DRD2/4 -> Membrane Transport
GALR1/2/3 -> POMC/NPY Production
CHRM1 -> IL2 Production
CHRM1/2/3/5 -> Ion Channels
PTGER2/3 -> Vascular Motility
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
TACR1 -> TNF/IL6/IL8 Production
Leptin -> NO Production/Vasodilation
NTRK1/2/3 -> Acetylcholine Production
T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers
G0/G1 Phase Transition
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Dilated Cardiomyopathy
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Endothelial Cell Dysfunction in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
Myocarditis, Acute Viral Overiew
Vascular Reactivity in Raynaud Disease
NO Synthesis in Early Vasospasm
Neurons Necrosis Caused by Energy Deficiency
Contraction Due Vasospasm
Hyperseborrhea in Acne Vulgaris
Androgen Induced Sebocyte Hyperfunction
Androgens in Sebocyte Maturation
Atopic Dermatitis Onset
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
Dedifferentiation and Metastatic Progression in Melanoma
MITF as a Regulator of Melanoma Cell Development
Proteins Involved in Melanoma
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Dendritic Cells Function in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
AGE Related Insulin Resistance in Skeletal Muscles
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
PNPLA3 in non-Alcoholic Fatty Liver Disease
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
Leptin in Insulin Synthesis and Secretion
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Mass Regulation
beta-Cell Function Inhibition by Ciclosporine and Tacrolimus (Rodent Model)
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
RET1 Mutation in Hyperparathyroidism
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
Graves Ophthalmopathy
Immune System Activation in Hyperthyroidism
Hypothyroidism, Secondary (Central)
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Thymic Follicular Hyperplasia
Adipocyte Hypertrophy and Hyperplasia
CD4+T-Cell Response in Celiac Disease
Enterocyte Mediated Mucosal Damage in Celiac Disease
Metastatic Colorectal Cancer
GUCY2C Signaling in Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
Peutz-Jeghers Syndrome
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
Antiphospholipid Antibodies in Platelets and Coagulation Cascade
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Lymphoma, GCB Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Hedgehog Signaling in Mantle Cell Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
T-Cell Acute Lymphoblastic Leukemia
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
STK11 Signaling in Pancreatic Neoplasms
Il17 Signaling Related Neutrophilia in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Exocytosis in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
B-Cell Mediated IgE Production in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Ovulation Block
SHBG and IGFBP1 Synthesis Decline in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
CD4+ T-Cell Function Decline in HIV
Macrophage Survival through CCR5 and CXCR4 Mediated Signaling
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Mevalonate Kinase Deficiency
Blau Syndrome
Familial Cold Autoinflammatory Syndrome 2
Hereditary Hemorrhagic Telangiectasia
Cowden Syndrome
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
IL6 and Insulin Resistance in Muscular Dystrophies
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Osteoblast Function Decline in Osteoporosis
BDNF Upregulation Triggered by Seizures
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Glioma Invasion Signaling
Glioma Stem Cell Program Activation
Ependymoma
Medulloblastoma
Vascular Endothelial Cell Vasodilation in Brain
Dopamine Action in CSD Progression
Postsynaptic Neuron Activation
nNOS (NOS1) and iNOS (NOS2) Activation via Glutamate
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
Glutamate Role in Parkinson's Disease
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
MIR155 Role in Th17-Cell in Multiple Sclerosis
Brain Cell Necrosis in Vascular Dementia
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
LH and FSH Signaling Impairment in Primary Ovarian Insufficiency
FOXO3 and PTEN Inactivation in Premature Ovarian Failure (Mouse Model)
MIF Role in Cholesteatoma
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
Prostate Cancer
Androgen Receptor/SGK1 Signaling
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Polycystins Mutation Effects in Cystic Kidney Disease
Penile Detumescense Augmentation Mechanisms
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Ammonia Effects on Brain Cells
CD157/ITGB2 Signaling in Myeloid Cell
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
AREG -> FOXO3A Expression Target
Noradrenaline/Gs Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
AGTR1 -> ARRB1/ARRB2 Signaling
Hedgehog Family -> ARRB1/ARRB2 Canonical Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
Tamoxifen Induced Endometrial Cancer
Dexamethasone Induced Diabetes
Doxorubicin Induced Cardiotoxicity
Ritonavir Induced Diabetes
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> FOXO3A Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> FOXO3A Expression Target
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> FOXO3A Expression Targets
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> FOXO3A Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> FOXO3A Expression Target
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF10 -> FOXO3A Expression Target
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FSHR Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> FOXO3A Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> FOXO3A Signaling
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
PI3K/AKT/MTOR Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
Hypoxia-Induced Cell Death Evasion in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
Inhibition of THBS1 Activates Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
MTOR/TORC in Cancer Cell Motility and Invasion
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Invadopodia Formation in Cancer Cells
Skeletal Muscle Wasting in Cancer Cachexia
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
Lipogenesis/Lipolysis Activation in Cancer Cells and Cancer-Associated Adipocytes
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> CEBPA/FOXO1A Expression Targets
IGF2 -> CEBPA/FOXO1A Expression Targets
IGF2/MEF/MYOD Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
CD19 -> NF-kB Signaling
AGER -> NF-kB Signaling
ICAM2 -> CTNNB/FOXO/STAT3 Signaling
FcIgER -> ELK-SRF Signaling
InsulinR -> CTNNB/FOXA/FOXO Signaling
InsulinR -> ELK/SRF/SREBF Signaling
IGF1R -> CEBPA/FOXO1A Signaling
IGF1R -> MEF/MYOD/MYOG Signaling
FibronectinR -> CTNNB Signaling
FibronectinR -> NF-kB Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
MacrophageR -> CEBPB -> NF-kB Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> FOXO3A Expression Target
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
Fibrinogen Expression Targets
IL7R -> FOXO/NF-kB Signaling
IL15R -> NF-kB/NFATC Signaling
IL2R -> ELK/SRF/MYC Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL7 Expression Targets
IL15 Expression Targets
IL12B Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
PAF/Gq -> NF-kB Expression Targets
GPCRs Family -> Expression Targets in Lymphoid System and Blood
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> FOXO3A Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> NF-kB Signaling
DLL4 Expression Targets
ADAM17 Expression Targets
JAG1 Expression Targets
DLL1 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFB -> FOXO3A Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> FOXO3A Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
PDGFR -> FOXO3A Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
NTS Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
NPY Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
GUCYC2 Signaling
AngiopoietinR -> AP-1 Signaling
AngiopoietinR -> FOXO Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> FOXO/MYCN Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> FOXO3A Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
Elevated Receptors -> Expression Targets in Respiratory System
Lysophosphatidic Acid/LPARs Signaling
FOXO1 Signaling
MERTK Signaling
Ras Signaling
TGF-beta Signaling
AXL Receptor Tyrosine Kinase Signaling
PI3K/RAC1 Signaling
mTOR Signaling
TNF-alpha/TNFRSF1B Signaling
KRAS Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
HRAS Signaling
Hedgehog Family Signaling
T-Cell Receptor -> NF-kB Signaling
TGFA -> FOXO3A Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13B Expression Targets
TNFRSF5/13B -> NFATC1 Signaling
Thrombopoietin -> SPI1 Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> FOXO3A Expression Target
TLR1 -> 2/6 Expression Targets
TLR1/2/6 -> NF-kB Signaling
Glutamate Mediated Neurotoxicity
Ca2+ Cytosolic Overload
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFC -> CTNNB Expression Target
VEGFA -> FOXO3A Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> CTNNB Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> FOXO3A Signaling
n
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
3_Increased proliferation of sebocytes in acne vulgaris
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
2_Osteoblast-mediated bone demineralization
1_Formation of cysts in polycystic kidney disease
3_Mesangial cell dysfunction in glomerulonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
4_Endothelial cells repress vasoconstriction in hypertension
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Triglyceride storage in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
4_Tax-induced disruption of the G1/S transition in HTLV-1 infected T-cell
2_HIV - induced depletion of CD4+ T-cells
3_1_Beta-cell proliferation and compensation: proliferation
1_1_Insulin synthesis and secretion: insulin processing and storage
3_3_Beta-cell proliferation and compensation: recovery
4_1_Insulin resistance: insulin signaling
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
1_Microangiopathy in diabetic neuropathy
2_Neuron and Schwann cell death
1_Glutamate and calcium excitotoxicity of motor neurons in ALS
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
2_1_General pathways of thyroid hormone signaling
Model of PPARG signaling in psoriais (tested)
DIPG non histone mutations
DIPG overview_2
HRAS->RAF->MAPK1/3
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Cowden Syndrome

Source curated
GO component
Biopax

MedScan ID 5170

LocusLink ID 5170
18607
81745
28993
792239

Alias PkB kinase like gene 1
3-phosphoinositide dependent protein kinase I
OTTMUSP00000022125
PDPK1
PkB-like
PkB-like I
OTTHUMP00000174525
PkB kinase
mPDK1
PDPK2
PkB-like 1
PkB kinase like gene I
MGC35290
MGC20087
PDPK I
PRO0461
Phosphoinositide-dependent kinase 1
3' phosphoinositide dependent protein kinase 1
Pdk I
protein kinase B kinase
hPDK I
3-phosphoinositide dependent protein kinase-1
PDK1
hPDK1
mPDK-1
OTTMUSP00000022124
RP23-153H18.1
OTTMUSP00000017452
PDPK2P
3-phosphoinositide-dependent protein kinase 2 pseudogene
3-phosphoinositide-dependent protein kinase 1
protein kinase
PDK-1
PIP3
PREDICTED: SIMILAR TO 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1(HPDK1).
scaffold
chromosome
hypothetical protein LOC792239
LOC792239

EC Number 2.7.11.1
2.7.1.37

GO ID 0004676
0005524
0005158
0016004
0043274
0019901
0004674
0038095
0031295
0050852
0030036
0032148
0019722
0016477
1990416
0071364
0032869
0007173
0097191
0048041
0006972
0035556
0010667
2000352
0043524
0006469
0034122
0030512
0018105
0018107
0030168
0045766
0043536
0010518
1903078
0051281
1903672
1905564
0046777
0006468
0043122
0043304
0002223
0003323
0042995
0005737
0031410
0005829
0005925
0016020
0005634
0043204
0005886
0014069
0016301
0000166
0004672
0016740
0016310
0010594
0007165
0030054
0048015
0090004
0006355
0006351
0016023
0005622
0097481
0005654
0007596
0008543
0045087
0008286
0048011
0007268
0048010
0016772
0042981
0023034
0007242
0005515
0070201
0004197
0006508
0004713
0000287
0030295
0004682
0004691

KEGG ID rno:81745
hsa:5170
mmu:18607

MedLine Reference 10792047
9368760
9637919
9445477
10075713
12783890
14585963
16314505
10349636
11042159
11076861
11217851
11877406
11964154
12006370
12054753
12110585
12177059
12372837
12420226
12466851
12711546
12855688
12912918
12923190
12970179
14500370
14623982
15077109
15116068
15187024
15309345
15389876
15531926
15782199
15961082
16141072
16141073
16150867
16217033
16219676
16243031
16563390
16581799
16642023
16741145
16785309
16825708
16923125
17027005
17077284
8889548
10191262
10226025
10357815
10455013
10480933
10548550
10601311
10698680
10698939
10753910
10764742
10856237
10896934
10945988
10995762
11062054
11222751
11278835
11313365
11376011
11381116
11438723
11445557
11481331
11733037
11779851
11781095
11825911
11889038
12048203
12147684
12149249
12162751
12167717
12169624
12387817
12477932
12485998
12640464
14500673
14604990
14702039
14749367
15059930
15144186
15210700
15302935
15741170
15743829
15802604
15802620
16207722
16288304
9094314
9271440
9373149
9374542
9427642
9430688
9445476
9512493
9748166
9895304
10364160
11157489
15489334
16551362
16807684
17081983
17136479
17255356
8125298
15616553
15554902
16887794
17114649
17599070
17617409

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Human

Mouse chromosome position 17
17 A3.3

OMIM ID 605213
OMIM:605213

Rat chromosome position 10q12

Hugo ID 8816
HGNC:8816

Human chromosome position 16p13.3

Swiss-Prot Accession O15530
O15530.1
Q6A1A2.1
Q3TRL2
F2Z3X6
Q3UGN6
Q3UHZ0
Q9Z2A0
Q9Z2A0.2
O55173
O55173.2
G3V9W3
H0Y4Z0
Q59EH6
Q6FI20
Q8IV52
Q9BRD5
A6H6U3
Q9R1D8
Q9R215
E9PER6
Q6A1A2
Q53HJ9
Q9UPJ7
Q9UPJ8
Q3UEW8
Q810Z4
Q8K3L3
Q9UI25
PDPK1_HUMAN
PDPK1_MOUSE
PDPK1_RAT
Q9BRD5_HUMAN
A6H6U3_MOUSE
Q3TRL2_MOUSE
Q3UHZ0_MOUSE

GenBank ID NC_000016
XM_024450296
XP_024306064
XM_017023274
XP_016878763
XM_017023273
XP_016878762
NM_002613
NP_002604
NM_001261816
NP_001248745
XM_017023277
XP_016878766
XM_017023276
XP_016878765
NM_031268
NP_112558
XM_024450295
XP_024306063
XM_017023275
XP_016878764
XM_017023271
XP_016878760
XM_011522523
XP_011520825
XM_011522521
XP_011520823
XM_017023272
XP_016878761
AC005591
AAC33797
AC093525
AC141586
AJ406809
CAC10873
CH471112
EAW85495
AB209835
BAD93072
AF017995
AAC51825
AF111845
AAF16685
AJ785968
CAH05056
AK095507
AK131060
AK222581
BAD96301
AK293900
BAG57287
AL157446
BC000789
BC006339
AAH06339
BC012103
AAH12103
BC012540
BC033494
AAH33494
BC040324
BI830733
CR536517
CAG38755
Y15056
CAA75341
O15530
Q6A1A2
NC_000083
NM_001286662
NP_001273591
NM_001080773
NP_001074242
NM_011062
NP_035192
XM_017317323
XP_017172812
XM_017317324
XP_017172813
XM_017317325
XP_017172814
XM_017317320
XP_017172809
XM_017317321
XP_017172810
XM_017317322
XP_017172811
XM_017317327
XP_017172816
XM_017317326
XP_017172815
AY162410
AAO17164
CH466606
EDL22291
CT010502
AF079535
AAC96115
AF086625
AAC67544
AF126294
AAD38505
AK047229
AK079579
AK143283
AK147149
BAE27716
AK147835
BAE28171
AK149162
AK149289
BAE28793
AK162677
BAE37017
AK165564
AK188106
AK193731
AK205439
AK215448
AK219503
AY062008
AAL47185
BC146001
AAI46002
BC146003
AAI46004
BQ175596
BY257456
BY267833
CJ046953
Q9Z2A0
NC_005109
XM_006246036
XP_006246098
NM_031081
NP_112343
AC_000078
AAHX01062886
AAHX01062887
AAHX01062888
AAHX01062889
AC130139
CH473948
EDM03805
EDM03806
Y15748
CAA75758
O55173
XM_005255356
XP_005255413
XM_011522524
XP_011520826
XM_011522522
XP_011520824
NC_018927
AMYH02031255
AMYH02031256
AMYH02031257
AMYH02031258
AMYH02031259
AMYH02031260
DQ892297
ABM83223
DQ895496
ABM86422
EU832784
ACE87795
GQ129441
ACT64575
AC_000039
AAHY01131618
AAHY01131619
AAHY01131620
AAHY01131621
AAHY01131622
XM_006246038
XP_006246100
AC_000148
ABBA01030247
ABBA01030248
XM_006523825
XP_006523888
XM_006523828
XP_006523891
XM_006523829
XP_006523892
XM_006523827
XP_006523890
XM_006523826
XP_006523889
XM_006523823
XP_006523886
XM_006523824
XP_006523887
XM_006523830
XP_006523893
XM_006246037
XP_006246099
AABR06062999
AABR06063000
AABR06063001
NT_010393
NW_001838339
NW_926094
NW_927923
NW_926315
Q53HJ9
Q59EH6
Q9BRD5
Q9UPJ7
Q9UPJ8
NT_039649
NW_001030605
Q3TRL2
Q3UEW8
Q3UGN6
Q3UHZ0
Q810Z4
Q8K3L3
NW_047334
NW_001084656
NT_037887
NW_926018
AC_000059
Q6FI20
XM_939834
Q9UI25
BQ174223
NT_086834
NW_000124
XP_944927
47680172
AAC33798
4505695
47680168
47680169
51473214
3513293
3513294
3513295
2407612
2407613
6560611
6560612
21754775
34528313
7018448
13937557
33873510
33873511
15082378
15082379
15214808
23271394
23271395
26007919
15942283
49168519
49168520
2505935
2505936
17380162
9910796
51770238
6755019
6755020
4028126
4028127
3789924
3789925
5052327
5052328
21632794
21632795
18203660
34872015
13592022
13592023
2665355
2665356
18202068
NM_002610
51473210
123784580
123787012
123791192
123791350
28188759
74143425
74151190
74190754
74200494
81895608
81914684
10637404
123997641
62089256
62896721
74721242
74721243
74732868
74740587
74741106
74757560
XM_001130789
XP_001130789
NC_007135
NW_001512718
XM_001331617
XP_001331653
119605901
123982964
123234536
123234537
123234538
123234539
123234543
148690344
148877961
148878393
CAM19484
CAM19485
CAM19486
CAM19487
CAM19491
149051988
149051989
XP_030105432
XP_030105433
XP_030105434
XP_030105435
XM_030249573
XM_030249572
XM_030249575
XM_030249574

Swiss-Prot ID PDPK1_RAT
PDPK1_HUMAN
PDPK1_MOUSE
Q3UHZ0_MOUSE
Q3UGN6_MOUSE
Q3TRL2_MOUSE
Q9BRD5_HUMAN
A6H6U3_MOUSE

Cell Localization Cytoplasm
Nucleus
Cell membrane
Cell junction
Focal adhesion
Cell junction, focal adhesion
Membrane
Plasma membrane

Ensembl ID ENSG00000140992
ENSP00000395357.3
ENST00000441549.7
ENSP00000344220.4
ENST00000342085.9
ENSP00000268673.7
ENST00000268673.11
ENSP00000373876.3
ENST00000389224.7
ENSMUSG00000024122
ENSMUSP00000111070.1
ENSMUST00000115411.7
ENSMUSP00000061942.6
ENSMUST00000052462.12
ENSMUSP00000099991.3
ENSMUST00000102927.9
ENSRNOG00000006136
ENSRNOP00000061683.1
ENSRNOT00000067660.1
ENSP00000395357
ENST00000441549
ENSP00000344220
ENST00000342085
ENSP00000268673
ENST00000268673
ENSP00000373876
ENST00000389224
ENSMUSP00000111070
ENSMUST00000115411
ENSMUSP00000061942
ENSMUST00000052462
ENSMUSP00000099991
ENSMUST00000102927
ENSRNOP00000061683
ENSRNOT00000067660
ENST00000342085.8

MGI ID MGI:1338068
1338068

RGD ID 620307

Unigene ID Hs.459691
Mm.10504
Rn.10905
Hs.154729
Dr.29812

Homologene ID 37643

Shape Sickle-vertex

IPI ID IPI00195987
IPI00002538
IPI00216646
IPI00216647
IPI00323609
IPI00828763
IPI00216877
IPI00005991
IPI00867720
IPI00478389
IPI00831145
IPI00831240
IPI00831328
IPI00831411
IPI00830337
IPI00831634
IPI00455277

Chromosome position 10q12
16p13.3
17 A3.3

Microarray ID 1370052_at
y15748_at
A_43_P12504
102063_at
134947_r_at
1416501_at
msa.34345.0_s_at
A_51_P207140
A_52_P619138
Y15056
222260_at
32029_at
73168_s_at
204524_at
224986_s_at
232050_at
RC_AA041276_at
rc_aa019394_at
221244_s_at
64052_at
rc_aa488978_at
A_14_P128757
A_23_P66219
A_14_P107472
A_14_P120883
A_24_P830690
A_14_P123854
A_24_P222599
A_32_P344843
A_23_P10614
A_24_P37441
OH8695
CA422
OH2464
OR3282
RA1061
160578_at

Homo sapiens Chromosome position 16p13.3

Ensembl Transcript ID ENST00000268673
ENST00000342085

ENSEMBL ENSG00000140992

FunctionalClass 3-phosphoinositide-dependent protein kinase
insulin receptor binding
protein kinase activator
protein kinase binding
ATP binding
kinase
nucleotide binding
protein kinase
protein serine/threonine kinase
transferase
protein-tyrosine kinase
cAMP-dependent protein kinase
magnesium ion binding
protein kinase CK2
protein binding

Hugo Symbol PDPK1

Mus musculus Chromosome position 17 A3.3

KEGG pathway Insulin signaling pathway
Focal adhesion
PPAR signaling pathway
mTOR signaling pathway
Endometrial cancer
Non-small cell lung cancer
Prostate cancer

Rattus norvegicus Chromosome position 10q12

Ensembl Gene ID ENSG00000140992

ProteinAtlas NormalTissue Tissue: ovary; Cell type: ovarian stroma cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: lymphoid tissue; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix
uterine; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: stomach
upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: vagina; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in granular layer; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus
post-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: adrenal gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: breast; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: colon; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: duodenum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: epididymis; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: fallopian tube; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: gall bladder; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: heart muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in glomeruli; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in tubules; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: glial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: bile duct cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: hepatocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: macrophages; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: islets of Langerhans; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: parathyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: decidual cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: trophoblastic cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: prostate; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: rectum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: salivary gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: seminal vesicle; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: skeletal muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: small intestine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in red pulp; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, lower; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: thyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: urinary bladder; Cell type: urothelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive

EnzymeConsortium 2.7.1.37