Protein KRAS

URN urn:agi-llid:3845
Total Entities 0
Connectivity 4266
Name KRAS
Description Kirsten rat sarcoma viral oncogene homolog
Notes This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
ObjectType Protein

Pathway Genes with Mutations Associated with Aging in Humans
Osteoarthritis
Oncogene Induced Cellular Senescence
mTOR Signaling
mTOR Signaling Hyperfunction
SIRT2 Signaling in Aging
Insulin Signaling
Toll-like Receptor Independent Sterile Inflammation
CHRNA7 -> NOS1 Production
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Arterial Hypertension
Endothelial Cell Dysfunction in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Arterial Hypertension
Myocardial Remodeling
Myocardial Infarction
Proteins Involved in Melanoma
Dendritic Cells Function in Psoriasis
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
AGE Related Insulin Resistance in Skeletal Muscles
Proteins Involved in Colorectal Neoplasms
Cetuximab Resistance in Colorectal Cancer
CagA Phosphorylation Dependent Signaling
FLT3/KIT/MLL Signaling in Leukemia
Proteins Involved in Acute Myeloid Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
Multiple Myeloma
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
Dendritic Cell Dysfunction in Psoriatic Arthritis
Diabetes Induced Periodontitis
Mevalonate Kinase Deficiency
Proteins Involved in Glioblastoma
Proteins Involved in Glioma
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
Endometrial Cancer
Endometrioid Endometrial Cancer
Proteins Involved in Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Genes with Mutations Associated with Endometrial Cancer
Proteins Involved in Endometriosis
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Genes with Mutations Associated with Ovarian Cancer
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Cholesteatoma
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
Acetylcholine Expression Targets
CHRNA7 -> CREB Signaling
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
NFKB Canonical Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
VEGFA Dependent Angiogenesis in Cancer
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
Genes with Mutations in Cancer Metabolic Reprogramming
Proteins with Altered Expression in Cancer Metabolic Reprogramming
IDO1 in Cancer Immune Escape
AGER -> NF-kB Signaling
AGER -> CREB/SP1 Signaling
FOXO1 Signaling
KRAS Signaling
Estrogens/ESR1 non-Genomic Signaling
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
H2A-K120, H2A-K119 and H3-K4
Epigenetic Modifications of H2A-K120, H2A-K119 and H3-K4
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Microangiopathy in diabetic neuropathy
2_Neuron and Schwann cell death
drug-target molsynthesis
Model of PPARG signaling in psoriais (tested)
public list
New Pathway
KRAS->RAFs->MAPK1/3

Group Genes with Mutations Associated with Colorectal Cancer
Genes Associated with Ulcerative Colitis
Genes with Mutations Associated with Acute Myeloid Leukemia
Genes with Mutations Associated with Multiple Myeloma
Genes with Mutations Associated with Hepatocellular Carcinoma
Genes with Mutations Associated with Pancreatic Cancer
Proteins Involved in Cowden Syndrome
Genes Associated with Syndromic Epilepsy
Genes with Mutations Associated with Breast Cancer
Genes with Mutations Associated with Endometrial Cancer
Genes with Mutations Associated with Ovarian Cancer

MedScan ID 3845

LocusLink ID 3845
16653
24525

Alias Kras2
c-K-ras2
AI929937
K-RAS2A
Kirsten rat sarcoma oncogene 2, expressed
c-K-ras
K-RAS4B
OTTMUSP00000025007
GTPase KRas
v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
K-Ras 2B
K-ras
c-Kirsten-ras protein
KRAS
KRAS proto-oncogene, GTPase
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
kras1
Kirsten rat sarcoma viral oncogene homolog
Kirsten rat sarcoma viral oncogene homologue 2 (active)
MGC7141
c-Ki-ras2
c-K-ras2 protein isoform b
c-K-ras proteins
K-ras p21
K-RasB
p21b
Kirsten rat sarcoma viral oncogene
OTTMUSP00000025006
oncogene KRAS2
transforming protein p21
Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog
K-RASA
cellular c-Ki-ras2 proto-oncogene
RP24-359O2.1
Kirsten rat sarcoma viral proto-oncogene
Ki-Ras
K-Ras 2
K-RAS4A
PR310 c-K-ras oncogene
c-Kirsten-ras proto-oncogene
RASK2
c-K-ras2 protein isoform a
c-Ki-ras
Transforming protein p21b
NS
NS3
CFC2
RALD
K-RAS2B
K-ras p21 protein
cellular transforming proto-oncogene
ras
Kras-2
p21 protein
p21
c-K-ras2 protein

GO ID 0019003
0019002
0005525
0003924
0030275
0044877
0000165
0007265
0030036
0019221
0038002
0060441
0007565
0021897
0048873
0001889
0045596
0043524
0043406
0051092
0035022
0008284
2000774
0010628
0051000
0001934
0048169
0031647
0032228
0051384
0035900
0051385
0002223
0051146
0008542
0005737
0005829
0031234
0005925
0016020
0045121
0005739
0005886
0000166
0007165
0005622
0032403
0006913
0045087
0006886
0000186
0005515
0007173
0038095
0007411
0008543
0048010
0048011
0038128
0035176
0007264
0050900
0006184
0008286
0007596
0005624
0007569
0006897

KEGG ID hsa:3845
mmu:16653
rno:24525

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6 77.37 cM
6 71.2 cM

OMIM ID 190070
601626
109800
260350
615278
108010
163200
114480
137215
211980
609942
614470
115150
218040

Rat chromosome position 4q44

Hugo ID 6407
HGNC:6407

Human chromosome position 12p12.1

Swiss-Prot Accession A0A024RAV5
P01116
I1SRC5
L7RSL8
P01116.1
P32883
Q5J7N1
Q0VDV7
P32883.1
A0JN17
P08644
P08644.3
A8K8Z5
B0LPF9
P01118
Q96D10
P04200
P08643
P46203
P97914
Q14014
Q14015
Q15285
Q71SP6
Q7KZ06
Q92668
Q3U2W7
Q53WZ3

PIR ID A93311
B93311
A01365
B01365
I58402

GenBank ID NC_000012
NM_001369787
NP_001356716
NM_001369786
NP_001356715
NM_004985
NP_004976
NM_033360
NP_203524
NG_007524
AC087239
AC092794
AF285779
AAF91482
AH001529
AAA36554
AH005283
AAB59444
AAB59445
CH471094
EAW96511
EAW96512
EAW96513
EAW96514
EF471933
ABP96992
EF471950
ABP97009
EF471954
ABP97013
EF471956
ABP97015
EF685661
ABS10683
EF685662
ABS10684
EU332849
ABY87538
HC464412
CBK51852
HC464568
CBK51925
HD032929
CBV35640
HM459605
ADQ00188
JC006857
CDL93479
JQ248012
AFF18187
JX512447
AGC09594
KF459678
KX302153
KY752515
ASO66780
KY828926
ASO66781
LC090171
LC090172
LC090174
LC090175
LC090177
LC090179
LC090180
LC090181
LC090182
LC090184
LC090187
LC090191
LC090192
LC090193
LC090194
M26261
AAA36148
M34904
AAA36149
MF083614
ASO66782
S64261
AAD13953
X01669
CAA25828
X02825
CAA26593
AA812162
AF493917
AAM12631
AI539465
AK292510
BAF85199
AW117295
BC010502
BC013572
AAH13572
BC029545
BG258021
BT007153
AAP35817
CD245555
M17087
AAA36555
M35504
AAA35689
M35505
AAA35690
M54968
AAB41942
P01116
NC_000072
XM_006506919
XP_006506982
XM_006506918
XP_006506981
NM_021284
NP_067259
NT_166305
AC157091
CH466572
EDL10686
CU207316
CU458742
JC006855
CDL93478
K01927
AAA40037
M16708
S39586
AAO46052
X02452
CAA26295
X02453
X02454
X02455
CAA26296
X02456
X15887
CAA33897
AK155064
BAE33023
AK164065
BAE37609
AY487807
AAS58056
BC004642
AAH04642
BC010202
AAH10202
BC014700
BC031623
BC119495
AAI19496
BC141051
AAI41052
U76425
U76426
X00485
CAA25160
P32883
NC_005103
XM_008763354
XP_008761576
XM_008763355
XP_008761577
NM_031515
NP_113703
XM_017592442
XP_017447931
XM_017592443
XP_017447932
AC_000072
AABR07062484
AAHX01033713
AAHX01033714
AH002242
AAA42011
CH473964
EDM01439
M54870
AAA40937
BC126086
AAI26087
FQ228206
FQ230946
FQ232665
U09793
AAB60458
P08644
XP_006536102
XP_006536103
X01228
M12260
XP_006237717
AC_000028
XP_006719132
XM_006237655
NC_018923
XM_008763353
XM_008763352
AABR06034275
XP_008761575
XP_008761574
ABBA01068017
ABBA01068018
AMYH02026221
AMYH02026220
DQ890649
AAHY01058889
K03210
XM_006536039
CAQ52125
CAQ52126
CAQ52124
XM_006536040
ABM81575
XM_006719069
L00049
L00048
L00047
L00046
L00045
L00044
AC_000144
XM_011520653
XM_005253365
XP_011518955
XP_005253422
DQ893829
ABM84755
K03209
CAQ52105
CAQ52106
NT_009714
NW_925328
NW_001838052
AC_000055
CR625034
Q14014
Q14015
Q15285
Q71SP6
Q7KZ06
Q92668
NT_039360
NW_001030820
Q0VDV7
Q3U2W7
Q53WZ3
Q5J7N1
NW_047696
NW_001084832

Swiss-Prot ID RASK_HUMAN
RASK_MOUSE
RASK_RAT
Q5J7N1_MOUSE
A0JN17_RAT
A8K8Z5_HUMAN
B0LPF9_HUMAN
Q3U2W7_MOUSE

Cell Localization Cell membrane
Cytoplasm
Cytosol
Cytoplasm, cytosol

Ensembl ID ENSG00000133703
ENSP00000308495.3
ENST00000311936.7
ENSP00000256078.4
ENST00000256078.8
ENSMUSG00000030265
ENSMUSP00000032399.5
ENSMUST00000032399.11
ENSMUSP00000107339.1
ENSMUST00000111710.7
ENSRNOG00000009338
ENSRNOP00000012887.2
ENSRNOT00000012887.6
ENSRNOP00000012588.2
ENSRNOT00000012588.4
ENSP00000308495
ENSMUSP00000032399
ENSRNOP00000012887
ENSRNOP00000012588
ENSMUST00000032399
ENSMUSP00000107339
ENST00000311936
ENSP00000256078
ENSRNOT00000012588
ENSMUST00000111710
ENSRNOT00000012887
ENST00000256078

MGI ID MGI:96680
96680

RGD ID 2981

Unigene ID Hs.505033
Mm.383182
Rn.24554

Homologene ID 37990

IPI ID IPI00134941
IPI00423568
IPI00210097
IPI00203826
IPI00113248
IPI00423570
IPI00790968
IPI00791238
IPI00845559
IPI00830951
IPI00857121