Protein FOS

URN urn:agi-llid:2353
Total Entities 0
Connectivity 7747
Name FOS
Description FBJ murine osteosarcoma viral oncogene homolog
Notes The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Osteoarthritis
Skin Aging
Oncogene Induced Cellular Senescence
Melatonin Effects on Circadian Cycle
Leptin and CCK8 Activate Nodose Ganglia Neuron
N-cell: Neurotensin Production
Dopamine Receptors Signaling
Prolactin Production
Thrombopoietin Receptors Signaling in Platelet Maturation
Cortisol in Resolving Inflammation
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
Natural Killer Cell Activation
CD8+ T-Cell Activation
Plasmin Effects in Inflammation
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Mast-Cell Activation without Degranulation through CXCR4 Signaling
Mast-Cell Activation without Degranulation
CD16/CD14 Proinflammatory Monocyte Activation
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
NTSR1 Expression Targets
ADRA1A -> IL6 Production
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD1/5 Expression Targets
PTGER2/3 -> Inflammation-Related Expression Targets
IL1B Expression Targets -> Nociception
Melatonin in Cell Survival and Antioxidant Response
Cell Cycle Overiew
G0/G1 Phase Transition
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Angiotensin-Aldosterone System Activation Scheme
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Endothelial Cell Dysfunction in Arterial Hypertension
Aldosterone Synthesis Chronic Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Myocardial Remodeling
Proteins Involved in Myocardial Ischemia
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Proteins Involved in Melanoma
IL17 Signaling in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Humoral Immunity in Vitiligo
Natural Killer Cell in Diabetes Mellitus Type 1
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Adiponectin Synthesis Declines in Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Mass Regulation
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
Thyroid Dysfunction
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
KISS1 Production Impairment in Hypogonadotropic hypogonadism
Adipokines Production by Adipocyte Impaired in Obesity
Prolactinoma Overiew
CD8+ T-Cell Response in Celiac Disease
GUCY2C Signaling in Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Acute Myeloid Leukemia
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Follicular Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Antiphospholipid Antibodies and Endothelial Cell Interaction
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
NOTCH Signaling in Hepatocellular Carcinoma
WNT Signaling in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TRPM7/8 in Pancreatic Adenocarcinoma
TGFBR Signaling in Pancreatic Neoplasms
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Periostin (POSTN) Production by Airway Epithelium in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Proteins Involved in Polycystic Ovary Syndrome
Ovulation Block
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Skin Fibrosis
CCR5 Signaling in Macrophages
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
Diabetes Induced Periodontitis
Estrogen Effects on Pregnancy Gingivitis
Majeed Syndrome
Hereditary Breast and Ovarian Cancer Syndrome
Cowden Syndrome
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
Gluten Impact on Neuronal System (Hypothesis)
beta-Casomorphins/Opioid Receptors Affect Brain Function (Hypothesis)
IL6 Promotes Inflammation in Muscular Dystrophies
Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Proteins Involved in Osteopetrosis
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
Metals and Amyloid beta Toxicity in Alzheimer's Disease
Proteins Involved in Epilepsy
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Glioma Invasion Signaling
Microglia and Motor Neuron Interaction Dysregulation
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to NOTCH Signaling Pathway
WNT Signaling in Breast Cancer
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
NOTCH1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
Proteins Involved in Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV Infection and Cancer
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
TRPM8 Effects in Prostate Cancer (Hypothesis)
ER Stress in Macular Degeneration
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
PGF2-alpha Effect on Treatment
MUC5AC Expression by NTHi and S. Pneumoniae
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
VEGFA Low Expression Level in Chronic Bronchitis
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
WNT Signaling in Cystic Kidney Disease
Polycystins Mutation Effects in Cystic Kidney Disease
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
S100B Expression Targets
ANGPT2 -> STAT Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CTF1 Expression Targets
Elevated Receptors -> Expression Targets in Myocardium
CXCL12 Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
Clozapine Induced Granulocytopenia
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> STAT Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> STAT Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF18 -> STAT Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF1 -> STAT Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
GCG Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
VIP Expression Targets
Elevated Receptors -> Expression Targets in Liver
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
WNT Canonical Signaling Activation in Cancer
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
WNT Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
MTOR/TORC in Cancer Cell Motility and Invasion
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF2 -> STAT Expression Targets
IGF1 -> STAT Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
CD19 -> JUN/ELK Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
Elevated Receptors -> Expression Targets in Skin
IFNG/IFNR Expression Targets
IL7 Expression Targets
IL13 Expression Targets
IL16 -> AP-1 Expression Targets
IL3 Expression Targets
IL6 Expression Targets
IL2 Expression Targets
PTPRJ Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
S1P Expression Targets
PGE1 Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
MTNR1 Signaling
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1/Catenin Expression Targets
NRG1 -> STAT Expression Targets
NRG1 -> AP-1/ATF Expression Targets
NCAM1 -> Expression Targets in Nerve Tissue
GPCRs -> Expression Targets in Brain
Elevated Receptors -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
GNRH2 Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
AVP/Gq -> STAT Expression Targets
TAC1 Expression Targets
AVP/Gs -> STAT Expression Targets
EDN3 Expression Targets
AGT -> STAT Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> AP-1 Expression Targets
AngiopoietinR -> AP-1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
CSF1 -> STAT Expression Targets
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
PAF Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TGFBR -> AP-1 Signaling
TGFBR1/AP-1 Signaling
TNF-alpha/TNFRSF1A Signaling
Lysophosphatidic Acid/LPARs Signaling
JNK/MAPK Signaling
Estrogens/ESR1 Genomic Canonical Signaling
MERTK Signaling
TGF-beta Signaling
AXL Receptor Tyrosine Kinase Signaling
TNF-alpha/TNFRSF1B Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
HRAS Signaling
ERK5/MAPK7 Signaling
ERK/MAPK Canonical Signaling
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> STAT Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
IL1B -> NO Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR -> AP-1 Signaling
PLAU -> STAT1 Expression Targets
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> STAT Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
pathway 3
ace2
PPARs and anxiety common targets
Amygdaloid expressed genes
New Pathway
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
1_Inflammation in keratinocytes in the pathology of acne
2_Hyperseborrhea in acne vulgaris
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Osteoblast-mediated bone demineralization
1_Osteoclast functional impairment in osteopetrosis
1_Formation of cysts in polycystic kidney disease
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
3_Endoplasmic reticulum stress in age-related macular degeneration
2_Pathogens stimulate mucins expression in the middle ear
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
3_1_Mucus accumulation in asthma
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
2_CD8+ T-cell response and mucosal damage in celiac disease
3_Human papilloma virus E4 and E5 proteins in viral reproduction
3_1_Beta-cell proliferation and compensation: proliferation
3_Islet beta-cell destruction in T1D
1_Microangiopathy in diabetic neuropathy
drug-target pairs binding
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Hereditary Breast and Ovarian Cancer Syndrome
Proteins Involved in Cowden Syndrome

Source curated
ResNet
GO component

MedScan ID 2353

LocusLink ID 2353
14281
314322
60585
24371
280795
394198
114281

Alias cellular oncogene fos
protooncogene Fos
protooncogene protein c-Fos
wb-Fos
transforming protein Fos
Cellular oncogene C-FOS
proto-oncogene cFos
FBJ murine osteosarcoma viral oncogene homolog
G0S7
FOS_HUMAN
Fos proto-oncogene, AP-1 transcription factor subunit
v-Fos FBJ murine osteosarcoma viral oncogene homolog
Fos-wb
FBJ osteosarcoma oncogene
D12Rfj I
Foswb
proto-oncogene c-Fos
G0/G1 switch regulatory protein 7
D12Rfj1
cFos
v-Fos oncogene homolog
oncogene Fos
wbFos
c-fos
OTTMUSP00000021331
v-Fos oncogene
v-Fos
Fos proto-oncogene, AP-1 trancription factor subunit
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
G0S7 proteins
FBJ murine osteosarcoma viral (v-fos) oncogene homolog
FBJ murine osteosarcoma viral
P55-C-FOS proto-oncogene protein
Fos
proto-oncogene Fos
transcription factor c-Fos
c-fos oncogene
LOC196935
p55
AP-1
activator protein 1
proto-oncogene protein c-fos
G0S7 proteins
G0S7 protein
wb-fos protein gene
Proto-oncogene protein c-fos (Cellular oncogene fos)
v-fos) oncogene homolog (oncogene FOS
similar to Proto-oncogene protein c-fos (Cellular oncogene fos)
Manh14
mandible shape 14
Manh14s
QTL-SH10.2
CH211-153J24.1
cb1065
chromosome
scaffold
zgc:77885

GO ID 0001228
0003700
0000981
0070412
0001102
0000979
0000978
0003682
0046982
0044212
0006306
0038095
0060395
0007568
0071276
0071277
0031668
0032870
0034614
0001661
0019221
0007565
0006954
0007399
1901216
0045672
1902895
0045944
0045893
0051090
0006357
0051591
0009409
0051412
0009629
0035902
0009416
0032496
0035994
0032570
0009636
0035914
0030431
0006366
0007179
0005829
0005783
0016020
0043005
0005654
0005634
0032993
0035976
0003677
0003690
0043565
0008134
0010468
0006355
0042493
0005737
0005667
0034097
0009612
0014070
0001077
0001190
0000982
0002755
0002756
0035666
0045087
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0005730
0008063
0034130
0006950
0010843
0003704
0051789
0006351
0019717
0005624
0046332
0046983
0045941
0009987
0051726
0000074
0050875
0005622
0007048
0008151
0005515

KEGG ID hsa:2353
mmu:14281
rno:314322

MedLine Reference 10488148
10497212
10523647
10764760
10777532
10799874
10918580
11053448
11134330
11260070
11278640
11397794
11397816
11641401
11846562
11891317
11909859
11983170
12052862
12082260
12127989
12147741
12183893
12193410
12445807
12446585
12477932
12547826
12592382
12600988
12687275
12692226
12705898
12788789
12949493
12972619
1406655
14511403
14517309
14522952
14629301
14702039
14741347
14966901
15188457
15262961
1545828
15507668
15530430
15548518
15588513
15654976
15708845
15767669
1589769
15921770
15926923
16038047
16049073
16055710
16123044
16219292
16236267
1631061
16552729
16637060
16828227
17018293
17182779
1828107
1903538
2414012
3027573
3555978
3817017
6574479
7540136
7665092
7685215
7713192
7816143
7816602
7962462
7994752
8065335
8108109
8248197
8397339
8475068
8557686
8570175
8628277
8710853
8737385
8763994
8904195
8971979
9057648
9121455
9129988
9207128
9334186
9346889
9443941
9468519
9510247
9642216
9671405
9681824
9685505
9732876
9792677
9888853
9918847
10349636
10352021
10524622
10528124
10559418
10569807
10627584
10655067
10711713
10828017
10973734
11039731
11042159
11069886
11076861
11151091
11217851
11566878
11731234
11747369
11755686
11813242
11829488
11925568
11948401
11961557
12054176
12082614
12083820
12091449
12219089
12220541
12239115
12366817
12376177
12383919
12438440
12466851
12486129
12489182
12562866
12595280
12654520
12694872
12719996
12782152
12876470
12882314
12902987
12943993
1329091
1383034
1406937
1423615
14511666
14526314
14534245
14555986
1465144
14656296
14699150
14706332
14706339
14980515
14982872
15005710
15056714
15067049
15073183
1508191
15121008
15143165
15169892
1517237
15182309
15207916
15247511
15292661
15294973
15464763
15476581
15519672
15522236
15590632
15607821
15618518
15619674
15719069
15721299
15733037
15752732
15758572
15772364
15795322
15834895
15913695
15944271
1594760
15972968
16002216
16007083
1605850
16141072
16141073
1616905
16172035
16263220
16288200
16313514
16359817
16424941
16434964
16530956
16569682
16636292
16687291
16892556
16916723
16966486
17066317
17130154
1889815
1909952
1914521
1957173
1970330
2140597
2351070
2452194
2506639
2515037
2575583
3004967
3082981
3108379
3127059
3147218
3186715
3457564
3894012
6088665
6090941
6093261
6205276
6289129
6292525
6301687
6306448
6319013
6479151
6514007
6541297
6607118
6641714
7476995
7514103
7545543
7547979
7595148
7600583
7600678
7601910
7656403
7689683
7700631
7720577
7741720
7758695
7806225
7807002
7824281
7841657
7910456
7911121
7922576
7929053
7939685
7955078
7989745
8007962
8007971
8017775
8025159
8036015
8036026
8039503
8082881
8088780
8095010
8114694
8131748
8134124
8136308
8144618
8150544
8179594
8194766
8196666
8198544
8258699
8264605
8275705
8276400
8281019
8286110
8335693
8364887
8369223
8397429
8405990
8479285
8482578
8486351
8491516
8565820
8566348
8573144
8580740
8612296
8643637
8656277
8668344
8678994
8750842
8754282
8757326
8777432
8790912
8793856
8800404
8831695
8847666
8896447
9055866
9058381
9098922
9099259
9120437
9162016
9169087
9180190
9183740
9210523
9221926
9310300
9344655
9664690
9710257
9710644
9723028
9799237
9804131
9840922
9858769
9876179
9918819
11025764
11766894
11790471
11846448
11850142
11861125
11939505
11956153
12064606
12121970
12145054
12184859
12215476
12370534
12384476
12429561
12443984
12528378
12531532
12535784
12606042
12629509
12638111
12714357
12787062
12834907
12946711
12965235
1298921
14576829
15306261
2105492
3140224
3325886
8889548
9434195
10199628
11766904
11861123
12802426
14625026
14674859
14757116
14767061
14979778
15024755
15033433
15044536
15051527
15115808
15136564
15189768
15249992
15254773
15334681
15380004
15453261
15458969
15609068
15701816
15702242
15842237
15922053
15926928
16055265
16095819
16097052
16110275
16130823
16344157
16531639
16547969
16604387
16633904
16926533
17005860
17020011
17101878
17111371
17147208
7990028
8206384
9879931
11282978
16305752
15730879
16000406
16379021
12508121
15489334
1658710
17160021
17203973
17209045
17235455
17606925
2511004
2516827
10820233
11106803
11134582
12766089
15157984
16275763
16339574
17141758
17178788
17189721
17192632
17392792
17458858
17482371
17485464
17531086
2991903
15014501
16962079
17006656
17120244
17152352
17194726
17216194
17218446
17244536
17448703
17514764
17622784
17654838
17661378
9571165
9847304

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Human
rat
mouse
Danio rerio
Bos taurus

Mouse chromosome position 12 39.7 cM
12 40.0 cM

OMIM ID 164810
2148821
OMIM:164810

Rat chromosome position 6q31

Hugo ID 3796
HGNC:3796

Human chromosome position 14q24.3

Swiss-Prot Accession P01100
Q6FG41
P01100.1
P01101
P01101.1
P12841
P12841.1
A8K4E2
B4DQ65
P18849
Q4FDN1
Q76MY9
Q76MZ0
Q3U463
Q6TDG4
Q5G6W2
Q5G6W3
Q5U7E3
Q5U873
Q5U874
Q5U875
Q63752
Q9EQC2
FOS_HUMAN
FOS_MOUSE
FOS_RAT
Q6FG41_HUMAN

PIR ID A01342
E34223
A01343
A28263

GenBank ID NC_000014
NM_005252
NP_005243
NG_029673
AB022275
BAA87920
AB022276
BAA87921
AF111167
AAC98315
AY212879
AAO21129
CH471061
EAW81227
EAW81228
EAW81229
HI574162
CBX47570
K00650
AAA52471
KT583865
V01512
CAA24756
AH003773
AAB20306
AK097379
BAG53458
AK290907
BAF83596
AK291326
BAF84015
AK298659
BAG60827
BC004490
AAH04490
BX647104
CR541785
CAG46584
CR542267
CAG47063
P01100
NC_000078
NM_010234
NP_034364
AC159244
CH466590
EDL02869
EDL02870
EDL02871
J00370
AAA96699
M23768
V00727
CAA24105
AK154418
BAE32571
AK159688
AY423854
AAR00345
BC013242
BC029814
AAH29814
P01101
NC_005105
NM_022197
NP_071533
AC_000074
AABR07065091
AAHX01045615
AF126534
AF277645
AAG47951
AY780201
AAV33852
AY780202
AAV33853
AY780203
AAV33854
AY786174
AAV41063
AY828998
AAW65541
AY828999
AAW65542
CH473982
EDL81573
EDL81574
EDL81575
DQ089699
AAZ13764
M34001
AAA42348
U02631
FQ225996
FQ228884
X06769
CAA29937
P12841
NC_018925
AC_000146
ABBA01030704
AMYH02029536
S65138
DQ893444
ABM84370
DQ896750
ABM87749
AC_000034
AAHY01101991
XM_005267488
XP_005267545
AABR06045297
NT_026437
NW_001838113
NW_925561
AC_000057
CR612516
CR620080
Q6FG41
Q76MY9
Q76MZ0
NT_039551
NW_001030502
Q3U463
Q6TDG4
NW_001084846
NW_047762
Q5G6W2
Q5G6W3
Q5U7E3
Q5U873
Q5U874
Q5U875
Q63752
Q9EQC2
AI059251
NW_000053
AV026617
BF547581
119601633
119601634
120470
124000481
13325364
182735
27802689
29904
4063509
49456527
49457528
6518629
6518635
74712937
74712938
74748440
120471
123787535
20988257
37695628
387161
50400
74181717
81864184
207685
120473
12056584
123781712
54398906
54398908
54398910
54873705
55934
58189915
58189917
70888329
81862069
81862070
81862661
81862662
81862663
81871952
81890364
81906232
Q4FDN1
NT_086807
XP_234422
XM_234422
109659357
120419460
3212099
32481980
76789652
AAC21577
AAI18281
AAP84343
ABM21549
AF069515
AY322482
BC118280
BT029837
NC_007308
NM_182786
NP_877587
NW_001492868
O77628
123905118
41107629
55962867
55962868
82079034
82202318
87241870
AAH65466
AAY21256
AL929435
BC065466
CAI11634
CAI11635
DQ003339
NC_007131
NM_205569
NP_991132
NW_001512152
Q4ZJF0
Q5SP68
Q6P0S4
119601635
123993537
148670922
148670923
148670924
149025206
149025207
149025208
6518634
27802688
34935858
34867433
34867434
4836596
12056583
413826
55933
51766990
31560587
6753894
193342
192565
50399
15301524
20988256
4572570
182734
29903
21757114
33872858
34366132
49456526
49457527
68869
68871
NW_043958
207684
3333028
11638646
51493278
6552332
4885241
51472322
6518628
ZDB-GENE-031222-4
45387566
45387567
126007383
394198
Dr.12986
dre:394198

Swiss-Prot ID FOS_HUMAN
FOS_MOUSE
FOS_RAT
Q6FG41_HUMAN

Cell Localization Nucleus
Endoplasmic reticulum
Cytoplasm
Cytosol
Cytoplasm, cytosol
Intracellular

Ensembl ID ENSG00000170345
ENSP00000306245.4
ENST00000303562.9
ENSMUSG00000021250
ENSMUSP00000021674.6
ENSMUST00000021674.6
ENSRNOG00000008015
ENSRNOP00000010712.2
ENSRNOT00000010712.3
ENST00000303562.8
ENSP00000306245
ENST00000303562
ENSMUSP00000021674
ENSMUST00000021674
ENSRNOP00000010712
ENSRNOT00000010712

MGI ID MGI:95574
95574
2148821

RGD ID 2626
735054

Unigene ID Rn.103750
Hs.25647
Mm.246513
Hs.728789
Hs.718415
Hs.568953
Bt.52605
Dr.12986
Mm.5043

Homologene ID 3844

Shape O-vertex

IPI ID IPI00131985
IPI00033008
IPI00368000

Proteome Biochemical Function DNA-binding protein

Chromosome position 12 40.0 cM
6q31
14q24.3

Microarray ID 160901_at
161716_at
1371283_at
x03347cds_g_at
x06769cds_at
x06769cds_g_at
A_42_P552092
100490_at
A_65_P03817
A_51_P333146
A_52_P262219
V01512
229173_at
71524_at
88628_at
209189_at
1915_s_at
1916_s_at
2094_s_at
V01512_rna1_at
rc_n23730_s_at
A_32_P75334
A_23_P106192
A_14_P107571
A_14_P117160
A_23_P106194
M494
C277
OH8074
OR3846
MB484
R549
OR0720
203358_Rn
1423100_at
97628_at
v00727_s_at
Msa.2013.0_at
A_65_P07422
H3084G03-3
NM_010234.1
NM_010234
234463_at
I_959033

Homo sapiens Chromosome position 14q24.3

Ensembl Transcript ID ENST00000303562

ENSEMBL ENSG00000170345

Proteome Cellular Role Chromatin/chromosome structure
Pol II transcription

FunctionalClass DNA binding
double-stranded DNA binding
protein heterodimerization
specific RNA polymerase II transcription factor
transcription factor
protein dimerization
sequence-specific DNA binding
contributes_to

Molecular Function Transcription Factor

Hugo Symbol FOS

Bos taurus Chromosome position 10

Mus musculus Chromosome position 12 40.0 cM

Proteome Subcellular Localization Nuclear

Compartment void
nucleus

KEGG pathway B cell receptor signaling pathway
Colorectal cancer
MAPK signaling pathway
T cell receptor signaling pathway
Toll-like receptor signaling pathway

ProteinAtlas SubcellularLocation Main location: Nucleus but not nucleoli; Other location: ; Expression type: Staining; Reliability: Supportive

RefSeq ACCNUM NP_005243

State p

Rattus norvegicus Chromosome position 6q31

Ensembl Gene ID ENSG00000170345

Keyword transcription factor
nucleus
early growth response
RAS small monomeric GTPase
oncogene
leucine zipper
bzip transcription factor
hnRNA
antisense RNA
cytoplasm
factor C
DNA bending
RNA
thrombin
DNA binding activity
binding activity
cytosol
nuclei
septum
leucine repeat
basic leucine zipper
growth-associated

ProteinAtlas NormalTissue Tissue: liver; Cell type: hepatocytes; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: bile duct cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: breast; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: urinary bladder; Cell type: urothelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: uterus
post-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: parathyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: germinal center cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
post-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: islets of Langerhans; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: rectum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: adrenal gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: lymphoid tissue; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in granular layer; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: colon; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: duodenum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: epididymis; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: fallopian tube; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: gall bladder; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: heart muscle; Cell type: myocytes; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: neuronal cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in glomeruli; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in tubules; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: macrophages; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: non-germinal center cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: follicle cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: ovarian stroma cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: decidual cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: trophoblastic cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: prostate; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: salivary gland; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: seminal vesicle; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: skeletal muscle; Cell type: myocytes; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: skin; Cell type: epidermal cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: small intestine; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in red pulp; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in white pulp; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: stomach, lower; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: Leydig cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: thyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: germinal center cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: non-germinal center cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: vagina; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive