Protein PTGS2

URN urn:agi-llid:5743
Total Entities 0
Connectivity 15393
Name PTGS2
Description prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Notes Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Primary Cell Localization Plasma membrane

Pathway Longevity Related Drugs
Somatostatin Receptors Signaling
Cortisol in Resolving Inflammation
Proplatelet Maturation
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
Lipoxins and Resolvins in Inflammation Resolution
Prostaglandin E2 Receptor Signaling in Neurons
Eicosanoids in Inflammation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Vascular Endothelial Cell Activation by NO
Vascular Endothelial Cell Activation by Growth Factors
Nociception Expression Targets Signaling
CCR1 Expression Targets
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
Prostaglandins Role in Sleep Regulation
Proteins Involved in Atherosclerosis
Proteins Involved in Arterial Hypertension
Arterial Hypertension
Endothelial Cell Dysfunction in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Proteins Involved in Myocarditis
Proteins Involved in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Proteins with Altered Expression in Androgenetic Alopecia
Proteins Involved in Melanoma
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Proteins Involved in Systemic Lupus Erythematosus
Genes with Mutations Associated with Vitiligo
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Proteins Involved in non-Alcoholic Fatty Liver Disease
Proteins Involved in Hashimoto's Thyroiditis
Proteins Involved in Obesity
Proteins Involved in Colorectal Neoplasms
Cetuximab Resistance in Colorectal Cancer
Metastatic Colorectal Cancer
EGFR Nuclear Signaling in Colorectal Cancer
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Helicobacter Infections
Proteins Involved in Peutz-Jeghers Syndrome
Proteins Involved in Ulcerative Colitis
Proteins Involved in Chronic Myeloid Leukemia
Proteins Involved in Hodgkin Lymphoma
Proteins Involved in Multiple Myeloma
Goblet-Cell Related Mucus Secretion in Asthma
Proteins Involved in Cystic Fibrosis
Monocytes Function in Gout
IL1B Induced Arthralgia
Proteins Involved in Osteoarthritis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Periodontitis
Proteins Involved in Osteoporosis
Microglia Activation in Alzheimer's Disease
Proteins Involved in Alzheimer's Disease
Proteins Involved in Epilepsy
Proteins Involved in Glioblastoma
Proteins Involved in Glioma
Dopamine Action in CSD Progression
Postsynaptic Neuron Activation
Estradiol Effects in Menstrual Migrane
Prostaglandin E2 Synthesis Activation via Glutamate in Familial Hemiplegic Migraine
Microglia Activation in Parkinson's Disease
Proteins with Altered Expression in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Proteins Involved in Amyotrophic Lateral Sclerosis
Proteins Involved in Multiple Sclerosis
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Local Estrogen Production in Endometriosis
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Proteins with Altered Expression in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Proteins Involved in Female Infertility
Proteins Involved in Spontaneous Abortion
FOXL2 Mutation in Ovarian Dysgenesis
BMP Signaling Impairment in Granulosa Cell in POF
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
Proteins Involved in Prostate Cancer
VEGFA in Neovascular Glaucoma
Proteins Involved in Hearing Loss
Proteins Involved in Otitis Media
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Cystic Kidney Disease
Proteins Involved in Glomerulonephritis
Proteins with Altered Expression in Prostate Cancer
Sertoli Cells Dysfunction Causes Male Infertility
HMGB1 Expression Targets
S100B Expression Targets
AREG -> NFATC Expression Target
AREG -> STAT Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
Aryl Hydrocarbon Receptor/Arachidonic Acid Metabolites Signaling
BMP2/BMPR2 Expression Targets
Receptor Tyrosine Kinase Family -> Expression Targets in Bone
GPCRs Family -> Expression Targets in Bone
Elevated Receptors -> Expression Targets in Bone and Joint
Elevated Receptors -> Expression Targets in Bone
CD80 -> STAT Expression Targets
CD81 Expression Targets
CD80 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD80 -> ATF/CREB/CREBBP Expression Targets
CTF1 Expression Targets
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Blood Vessel
CXCL1 Expression Targets
CXCL5 Expression Targets
CXCL12 Expression Targets
CCL3 Expression Targets
CCL7 Expression Target
IL8 Expression Targets
CSF3 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
CNTF Expression Targets
Valdecoxib Induced Ischemic Disease
Clozapine Induced Granulocytopenia
Cyclosporine Induced Nephrotoxicity
EGF -> CTNN Expression Targets
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> TP53 Expression Targets
EGF -> STAT Expression Targets
EREG -> STAT Expression Targets
EREG -> AP-1/ATF Expression Targets
Elevated Receptors -> Expression Targets in Endocrine Gands
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> STAT Expression Targets
FGF10 -> STAT Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
Elevated Receptors -> Expression Targets in Mouth
Elevated Receptors -> Expression Targets in Colon
GH1/GHR -> STAT Expression Targets
HBEGF -> STAT Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
HIF1A in Vasculogenic Mimicry of Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF2 -> STAT Expression Targets
IGF1 -> STAT Expression Targets
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Fibronectin Expression Targets
ICAM1 Expression Targets
EGFR -> Expression Targets in Skin
IFNG/IFNR Expression Targets
IL13 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
PGE1 Expression Targets
Omega-6-Fatty Acid Metabolism
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
TGF-beta Receptors Family -> Expression Targets in Lymphoid System and Blood
EGFR-> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1/Catenin Expression Targets
NRG1 -> STAT Expression Targets
NRG1 -> AP-1/ATF Expression Targets
PTGER4 -> Expression Targets in Nerve Tissue
P2RX7 -> Expression Targets in Nerve Tissue
Elevated Receptors -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
DLL1 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
OSM/OSMR Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
SST Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> STAT Expression Targets
TAC1 Expression Targets
AVP/Gs -> STAT Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
EDN3 Expression Targets
AGT -> STAT Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
PAF Expression Targets
Elevated Receptors -> Expression Targets in Seminal Vesicle
AMPK Signaling
VEGF Signaling
Androgen Receptor Genomic Signaling
TCR -> NFAT Expression Targets
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> STAT Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNF -> CREB Expression Targets
TNF -> STAT Expression Targets
TNF -> TP53/ATF Expression Targets
TLR3 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
ROS in Triggering Vascular Inflammation
ROS and RNS in Vasoconstriction and Vasodilation Regulation
Elevated Receptors -> Expression Targets in Kidney
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFA -> STAT Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
WNT1 Expression Targets
WNT5A Expression Targets
PPAR Psoriasis
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of skin thickness
Neighbors of insulin level
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of skin thickness
Neighbors of insulin level
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of osteoblast
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of lung fibroblast
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of spleen cell
Neighbors of neuroglia
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of brain cell
Neighbors of retina cell
Neighbors of peripheral lymphocyte
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of carotid artery
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of lymphatic system
Neighbors of colorectal region
Neighbors of alveolus
Neighbors of uterine cervix
Neighbors of arteriole
Neighbors of villus
Neighbors of nose
Neighbors of eye
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of mammary gland
Neighbors of cerebral cortex
Neighbors of brain blood vessel
Neighbors of bladder
Neighbors of nervous system
Neighbors of blastocyst
Neighbors of retina blood vessel
Neighbors of mesentery
Neighbors of corpus luteum of ovary
Neighbors of small intestine
Neighbors of knee joint
Neighbors of lymphatic vessels
Neighbors of choroid plexus
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of endothelin
Neighbors of NOS
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of alpha2 adrenoceptor
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of TLR1/2 heterodimer
Neighbors of FSH
Neighbors of TORC1
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of neuropeptides
Neighbors of histone acetyltransferase
Neighbors of adrenoceptor
Neighbors of phosphodiesterase
Neighbors of caspase
Neighbors of phosphoinositide phospholipase C
Neighbors of deacetylase
Neighbors of TLR4/Myd88
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
4_Endothelial cells repress vasoconstriction in hypertension
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
4_1_Polymorphisms associated with inflammatory bowel diseases
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
drug-target pairs direct regulation
New Combined Pathway
Differentiation of psoriatic T cells

Group Genes Hypermethylated in Melanoma
Genes with Mutations Associated with Vitiligo
Genes with Polymorphisms Associated with Migraine

MedScan ID 5743

LocusLink ID 5743
19225
29527

Alias prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Prostaglandin H2 synthase 2
PHS II
prostaglandin G/H synthetase
1DDX_B
prostaglandin G/H synthetase and cyclooxygenase II
prostaglandin G/H synthase and cyclooxygenase II
GRIPGHS
prostaglandin-endoperoxide synthase 2
PGHS2
hCox II
Prostaglandin H2 synthetase 2
PHS2
PGHS II
OTTHUMP00000033524
cyclooxygenase 2b
TIS10/PGS-2
prostaglandin G/H synthase
ciclooxygenase II
Prostaglandin G/H synthase 2
PGH synthase 2
cyclooxygenase II
prostaglandin-endoperoxide synthetase 2 (prostaglandin G/H synthetase and cyclooxygenase)
prostaglandin G/H synthase and cyclooxygenase 2
PES-2
Prostaglandin H2 synthase II
glucocorticoid-regulated inflammatory cyclooxygenase
Prostaglandin H2 synthetase II
cyclooxygenase (COX)-2
cyclo-oxygenase-2
macrophage activation-associated marker protein P71/73
PTGS2
prostaglandin-endoperoxide synthetase 2
Prostaglandin G/H synthetase 2
prostaglandin-endoperoxide synthetase II
PGH synthetase 2
cyclooxygenase 2 (COX-2)
PGS-2/TIS10
hCox-2
PGH synthetase II
prostaglandin G/H synthetase and cyclooxygenase 2
TIS10
ciclooxygenase-2
cyclooxygenase 2
prostaglandin-endoperoxide synthase II
1DDX_A
PGH synthase II
1DDX_Bs
1DDX_As
COX II
COX2
COX-2
PHS-2
PGG/HS
PGHS-2
cyclooxygenase-2
PGHS IIs
hCox IIs
prostaglandin G/H synthase and cyclooxygenase

EC Number 1.14.99.1

GO ID 0019899
0020037
0046872
0016702
0004601
0004666
0042803
0016740
0034356
0007568
0001525
0030282
0050873
0098869
0071318
0034644
0071498
0034605
0071456
0071284
0071260
0071471
0019371
0019221
0046697
0007566
0042633
0006954
0007612
0019372
0042759
0035633
0007613
0097756
0051926
0045786
0008285
0043154
1902219
0045986
0032227
0030728
0055114
0043065
0090336
0090050
0031622
0090271
0045429
0033138
0090362
0031394
0042307
0048661
0045987
0031915
0051968
0071636
0010575
0045907
0001516
0008217
0050727
0150077
1990776
0032355
0070542
0009750
0051384
0032496
0010226
0010042
0006979
0034612
0033280
0019233
0005901
0005737
0005783
0005788
0005789
0043005
0032991
0051213
0016491
0006633
0006631
0030216
0006629
0043066
0010942
0008284
0006693
0042127
0034097
0043231
0016020
0005634
0042493
0014070
0010033
0010243
0009314
0050473
0031090
0008289
0006928
0006769
0042346
0043234
0042640
0019674
0019369
0044281
0006766
0006767
0051726
0006805
0005635
0042446
0006692
0005792
0008610

KEGG ID hsa:5743
mmu:19225
rno:29527

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 1 63.84 cM
1 76.2 cM

OMIM ID 600262

Rat chromosome position 13q21

Hugo ID 9605
HGNC:9605

Human chromosome position 1q31.1
1q25.2-q25.3

Swiss-Prot Accession P35354
P35354.2
Q05769
Q05769.1
P35355
P35355.1
A8K802
Q16876
Q543K3
Q64379
Q925V4
Q6ZYK7
Q8IZA9
Q9NNY7
Q3UMR6
Q7TMV2
Q63124
Q8CIP1

PIR ID A46150
A49010
JC2030

GenBank ID NC_000001
NM_000963
NP_000954
NG_028206
AF044206
AF276953
AAF85977
AL033533
AY229989
AAO38056
AY382629
AAQ75702
CH471067
EAW91216
D28235
BAA05698
HC025790
CBH19826
HI519548
CBX54355
KF455116
L34209
AAN87129
U04636
AAA57317
U20548
U44805
AAD14842
AJ634912
CAG25548
AK292167
BAF84856
AY151286
AAN52932
AY462100
AAR23927
BC013734
AAH13734
BM978796
DA277667
HM473188
ADJ56342
L15326
AAA35803
M90100
AAA58433
P35354
NC_000067
NM_011198
NP_035328
AC114655
AH002100
AAA40448
CH466520
EDL39487
AK049923
BAC33986
AK144726
BAE26032
AK144956
BAE26154
AK149820
AK151293
AK166221
BAE38639
AK172161
BAE42855
BC052900
AAH52900
BY033144
CD547477
M64291
AAA39924
M88242
AAA37740
M94967
AAA39918
X98792
Q05769
NC_005112
NM_017232
NP_058928
AC_000081
AABR07021355
AAHX01075875
CH473958
EDM09586
EDM09587
AF159101
AF233596
AAF36986
AY157736
AAN52933
FQ222702
L20085
AAA40947
L25925
AAA16477
S67722
AAB29401
U03389
AAA03466
U04300
AAA20246
P35355
NC_018912
AMYH02002314
EU176282
ABW03733
EU176597
ABW03398
AC_000023
AAHY01012136
M82862
M82863
M82864
M82865
M82866
AC_000133
ABBA01027702
XM_006249971
XP_006250033
AABR06075371
CAB41240
NT_004487
NW_001838533
NW_926128
AC_000044
Q6ZYK7
Q8IZA9
Q9NNY7
NT_078297
NW_001030662
Q3UMR6
Q543K3
Q7TMV2
NW_001084685
NW_047397
Q63124
Q8CIP1

Swiss-Prot ID PGH2_HUMAN
PGH2_MOUSE
PGH2_RAT
Q543K3_MOUSE
A8K802_HUMAN

Cell Localization Microsome membrane
Endoplasmic reticulum membrane
Plasma membrane

Ensembl ID ENSG00000073756
ENSP00000356438.5
ENST00000367468.10
ENSMUSG00000032487
ENSMUSP00000035065.7
ENSMUST00000035065.8
ENSRNOG00000002525
ENSRNOP00000003567.2
ENSRNOT00000003567.4
ENST00000367468.9
ENSP00000356438
ENST00000367468
ENSMUSP00000035065
ENSMUST00000035065
ENSRNOP00000003567
ENSRNOT00000003567

MGI ID MGI:97798
97798

RGD ID 620349

Unigene ID Rn.44369
Rn.217585
Mm.292547
Hs.196384

Homologene ID 31000

IPI ID IPI00197645
IPI00308785
IPI00018109
IPI00447478
IPI00816025
IPI00462137