Protein S100A12

URN urn:agi-llid:6283
Total Entities 0
Connectivity 762
Name S100A12
Description S100 calcium binding protein A12
Notes The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]
ObjectType Protein

Pathway Toll-like Receptor Independent Sterile Inflammation
Proteins Involved in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Endometriosis
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of mortality
Neighbors of tumor recurrence
Neighbors of adverse outcome
Neighbors of leukocyte count
Neighbors of disease exacerbation
Neighbors of mortality
Neighbors of tumor recurrence
Neighbors of adverse outcome
Neighbors of leukocyte count
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of innate immune response
Neighbors of cell function
Neighbors of adaptive immune response
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of cell adhesion
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of SMC proliferation
Neighbors of cell damage
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of neutrophil recruitment
Neighbors of cell migration
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of monocyte recruitment
Neighbors of ossification
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of cell differentiation
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of atherosclerosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of chronic obstructive pulmonary disease
Neighbors of infection
Neighbors of preeclampsia
Neighbors of sepsis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of neutrophil infiltration
Neighbors of lung injury
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of lung disease
Neighbors of cardiovascular disease
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of vasculitis
Neighbors of coronary artery disease
Neighbors of osteolysis
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of monocyte
Neighbors of macrophage
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of endometrium cell
Neighbors of mononuclear cell
Neighbors of inflammatory cell
Neighbors of neutrophil
Neighbors of mononuclear phagocyte
Neighbors of granulocyte
Neighbors of myeloid cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of phagocyte
Neighbors of intestine
Neighbors of aorta
Neighbors of brain
Neighbors of cardiovascular system
Neighbors of cornea
Neighbors of ileum
Neighbors of NF-kB family
Neighbors of Jun/Fos
Neighbors of PKC
Neighbors of PI3K
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of JAK
Neighbors of NAD(P)H oxidase
Neighbors of TLR1/2 heterodimer
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway (5)
dsRNA induces innate immunity and INFs in alveolar cells
AGER feed forward loop in innate immunity
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
Model of PPARG signaling in psoriais (tested)

MedScan ID 6283

LocusLink ID 6283

Alias CAAF I
CAAF1
S100 calcium binding protein A12
extracellular newly identified RAGE-binding protein
Calcium- binding protein in amniotic fluid 1
S100 calcium binding protein A12 (calgranulin C)
Calgranulin C
S100A12
Neutrophil S100 protein
EN-RAGE
migration inhibitory factor-related protein 6
CAGC
OTTHUMP00000015332
Calcium- binding protein in amniotic fluid I
calcitermin
ENRAGE
p6
CGRP
MRP6
MRP-6
calcium-binding protein in amniotic fluid 1
protein S100-A12
S100 calcium-binding protein A12 (calgranulin C)
calgranulin-C

GO ID 0050786
0005509
0005507
0008270
0061844
0050663
0042742
0050832
0006954
0045087
0031640
0045576
0002548
0030593
0043312
0043123
0043406
0051092
0050729
0006805
0005737
0005856
0005829
0005576
0005634
0005886
0034774
0005515

KEGG ID hsa:6283

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Homo sapiens

OMIM ID 603112

Hugo ID 10489
HGNC:10489

Human chromosome position 1q21.3
1q21

Swiss-Prot Accession P80511
P80511.2
P83219
Q5SY66
Q7M4R1

PIR ID A61522
JC4712

GenBank ID NC_000001
NM_005621
NP_005612
AL591704
CH471121
EAW53332
D83657
BAA12030
X98288
X98289
CAB94792
X98290
BC070294
AAH70294
D49549
BAA08497
D83664
BAA12036
X97859
CAA66453
P80511
NC_018912
ADR82637
CAI19495
HQ257882
AMYH02001902
ABBA01049433
AC_000133

Swiss-Prot ID S10AC_HUMAN

Cell Localization Secreted
Cytoplasm
Cytoskeleton
Cell membrane
Cytoplasm, cytoskeleton

Ensembl ID ENSG00000163221
ENSP00000357726.3
ENST00000368737.5
ENSP00000357726
ENST00000368737.4
ENST00000368737

Unigene ID Hs.19413

IPI ID IPI00218131