Functional Class NAD(P)H oxidase

URN urn:agi-aopfc:0000479
Total Entities 3
Connectivity 5577
Name NAD(P)H oxidase
Description NADPH oxidase

ChildConcepts cytochrome b558
TC 5.B.1.2
NOX4

Pathway mTOR Signaling Activation by Fatty Acids and Glucose
Hypoxia Inhibits mTOR Signaling
Protein Oxidation and Aggregation in Aging
AMPK Related Catabolism Deceleration in Glucose Insufficiency
Lipoxin A4/FPR2-Related Neutrophil Depression
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Eosinophil Activation
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
Vascular Endothelial Cell Activation by NO
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
EDNRA/B -> Vascular Motility
ADRA1A -> IL6 Production
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Dilated Cardiomyopathy
Neurons Necrosis Caused by Energy Deficiency
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Oxidative Stress in Vitiligo
Vitiligo
Toll-like Receptors in beta-Cell
beta-Cell Death in Diabetes Mellitus Type 2
beta-Cell Recovery in Diabetes Mellitus
Hyperglycemia and Hyperlipidemia Trigger beta-Cell Apoptosis
Fatty Acids in Hypertension and Atherosclerosis Development
Eosinophil Activation and Degranulation in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
Neurotoxin Effects in Parkinson's Disease
Brain Cell Necrosis in Vascular Dementia
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
Alveolar Macrophages Dysfunction in COPD
Neutrophil Associated Lung Damage in Chronic Obstructive Pulmonary Disease
Penile Detumescense Augmentation Mechanisms
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
Proteins with Altered Expression in Erectile Dysfunction
Proteins Involved in Erectile Dysfunction
Doxorubicin Induced Cardiotoxicity
Cyclosporine Induced Nephrotoxicity
ROS Metabolism
EGFR Transactivation in Cancer and Non-Cancer Cells
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
Respiratory Chain Impairment in Cancer
AGT -> TP53 Expression Targets
AGT -> CREB Expression Targets
AGT -> ELK/SRF Expression Targets
TNF-alpha/TNFRSF1A Signaling
Ras Signaling
HIF1 Signaling
PI3K/RAC1 Signaling
ROS in Neutrophil Mediated Cell Damage
ROS in Triggering Vascular Inflammation
ROS and RNS in Vasoconstriction and Vasodilation Regulation
Ca2+ Cytosolic Overload
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
prarg neg,ukn expres targets, ps-positive
Neighbors of NAD(P)H oxidase
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
2_Chondrocyte death in osteoarthritis
2_Podocyte dysfunction in glomerulonephritis
2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
1_Low-density lipoprotein internalization and the accumulation of lipids in atherosclerosis
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
2_Hyperglycemia and hyperlipidemia trigger beta-cell apoptosis
3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation
3_Pain perception in diabetic neuropathy
2_Neuron and Schwann cell death

MedScan ID 12811045

Alias NAD(P)H oxidase complexes
NADP(H) oxidases
ThOXs
nicotinamide adenine dinucleotide phosphate oxidases
thyroid oxidase
ThOX
dual oxidases
NADPH oxidase complexes
thyroid NADPH oxidase
ThOX/DUOX
respiratory burst oxidase
superoxide-generating NADPH oxidases
Rbohs
superoxide-generating NADPH oxidase
DUOX
NADPH oxidase
neutrophil cytochrome B
NADH/NADPH oxidases
NAD(P)H:oxygen oxidoreductase
cytochrome b-245
NADH/NADPH oxidase
NADPH:oxygen oxidoreductase
flavoprotein NAD(P)H oxidase
NAD(P)H oxidase
NADH/NAD(P)H oxidase
superoxide-generating NADPH oxidase activity
NADPH oxidases
flavoprotein NADPH oxidase
DUOXes
Rboh
superoxide-generating NADP(H) oxidase
NADP(H) oxidase
nicotinamide adenine dinucleotide phosphate oxidase
NAD(P)H oxidases
respiratory burst oxidase homolog
respiratory burst oxidase homologs
reduced nicotinamide adenine dinucleotide phosphate oxidases
respiratory burst oxidases
NADH/NAD(P)H oxidases
respiratory burst oxidase homologue
1.6.3.1
flavoprotein NAD(P)H oxidases
superoxide-generating NAD(P)H oxidase
thyroid oxidases
thyroid NAD(P)H oxidase
dual oxidase
thyroid NADPH oxidases
DUOXs
NAD(P)H oxidase complex
NADP(H) oxidase complex
NADPH oxidase complex
superoxide-generating NAD(P)H oxidases
NADPH:oxygen oxidoreductases
thyroid NADP(H) oxidases
superoxide-generating NAD(P)H oxidase activity
thyroid NADP(H) oxidase
thyroid NAD(P)H oxidases
superoxide-generating NADP(H) oxidase activity
superoxide-generating NADP(H) oxidases
flavoprotein NADP(H) oxidases
flavoprotein NADP(H) oxidase
flavoprotein NADPH oxidases
cytochrome b558
flavocytochrome b558
NADP(H):oxygen oxidoreductases
NADP(H):oxygen oxidoreductase
NAD(P)H:oxygen oxidoreductases
NADH/NADP(H) oxidase
NADH/NADP(H) oxidases
Neutrophil cytochrome B

EC Number 1.6.3.1
1.6.9.91

GO ID 0016175

Cell Localization Cytoplasm