Protein IKBKB

URN urn:agi-llid:3551
Total Entities 0
Connectivity 4287
Name IKBKB
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Notes The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway mTOR Signaling Hyperfunction
Toll-like Receptors Act through MYD88-TIRAP Signaling
Antiviral Signaling through Pattern Recognition Receptors
TLR4 Signaling in Leukocytes
Plasmin Effects in Inflammation
Toll-like Receptors in Sterile Inflammation
Prostaglandin E2 Receptor Signaling in Neurons
Macrophage M1 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
SCF/FBXO7 Complex
Myocardial Remodeling
Myocardial Infarction
MAVS in Antiviral Innate Immune Response in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
B-Cell Activation in Systemic Lupus Erythematosus
Humoral Immunity in Vitiligo
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
AGE Related Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Adipose Tissue Inflammation Provokes Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
SOCS3 and PTPN1 in Hypothalamic Neuron Insensitivity to Insulin and Leptin
Enterocyte Mediated Mucosal Damage in Celiac Disease
Celiac Disease
OipA Signaling in Helicobacter Pylori Infection
Proteins Involved in Helicobacter Infections
CagA Phosphorylation Independent Signaling
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Splenic Marginal Zone Lymphoma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Club-Cell Role in Asthma
Antigen-Presenting Cell Role in Asthma
Osteoclast Activation in Gout
Monocytes Function in Gout
Dendritic Cell Dysfunction in Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
NF-kB Signaling Activation in Huntington Disease
Huntingtin Mutant Protein Toxicity Effects
Gluten Impact on Neuronal System (Hypothesis)
Osteoclasts Function in Osteopetrosis
Osteoclast Activation in Postmenopause
HMGB1 and IL1B in Neuroinflammation
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
OPTN Effects on NF-kB Signaling in Glaucoma
Immune System Role in Otitis Media
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
NFKB Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Telomeric Proteins/NFKB Positive Feedback Interplay in Cancer
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
IFNLR1-> STAT/NFKB Signaling
NF-kB Canonical Signaling
T-Cell Receptor -> NF-kB Signaling
pathway 4
sars-cov binding
dsRNA induces innate immunity and INFs in alveolar cells
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Osteoclast functional impairment in osteopetrosis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
2_HIV - induced depletion of CD4+ T-cells
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Ageing (Mammalian Animal Model)
Genes with Mutations Associated with Splenic Marginal Zone Lymphoma
binding partnetrs for SARSs

MedScan ID 3551

LocusLink ID 3551
16150
84351

Alias IKK2
Nuclear factor NF-kappa-B inhibitor kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta
NFKBIKB
FLJ33771
AI132552
I-kappa-B kinase II
IkB kinase II
inhibitor of kappa light polypeptide gene enhancer in B-cells, k
inhibitor of kappaB kinase beta
IMD15B
IkB kinase beta
NFKBIKBs
Inhibitor of nuclear factor kappa B kinase beta subunit
IKKB
FLJ40509
nuclear factor kappa B inhibitor kinase beta
IKK-B
inhibitor of nuclear factor kappa-B kinase subunit beta
NF kappa B inhibitor kinase beta
IMD15A
IKBKB
IKKbeta
FLJ38368
OTTMUSP00000022456
FLJ36218
IKK[b]
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase
MGC131801
I kappaB kinase beta
IkB kinase 2
I-kappa-B kinase 2
IMD15
IKK-beta
I-kappa-B-kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKK-2
AIM-1

EC Number 2.7.11.10

GO ID 0005524
0008384
0046982
0042803
0004672
0019901
0004674
0097110
0038095
0007249
0007252
0002756
0050852
0035666
0002479
0071356
0030866
0006954
0045087
0070498
0043066
1903347
0035509
0018105
0043123
0051092
0045944
0045893
0072659
0006468
1903140
0042325
0010803
0009615
0002223
0051403
0033209
0016032
0035631
0008385
0005737
0009898
0005829
0045121
0005634
0016301
0000166
0019903
0016740
0001782
0031175
0016310
2001259
0008284
1901216
0010976
0010765
0061847
0043231
0016020
0042493
0070542
0032496
0009636
0003009
0034146
0006916
0035872
0034142
0032481
0002755
0023014
0004702
0005515
0034134
0034138
0042501
0008063
0034130
0048011
0034166
0070423
0038123
0016772
0038124
0008152
0034162
0043122
0090002
0009653
0002224
0016563
0005792

KEGG ID hsa:3551
mmu:16150
rno:84351

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 8

OMIM ID 603258
615592
618204

Rat chromosome position 16q12.5

Hugo ID 5960
HGNC:5960

Human chromosome position 8p11.21
8p11.2

Swiss-Prot Accession O14920
O14920.1
Q5D0E0
A0A0R4J0T4
O88351
O88351.1
G3V8H5
Q9QY78
Q9QY78.1
B4DZ30
B4E0U4
O75327
Q9R1J6
B4DP95
Q32ND9
Q59GL9
Q05DR8
Q3U141
Q3USX8
Q3V454
Q8BQA9
E9PH46

GenBank ID NC_000008
XR_949402
NR_033818
NR_033819
NR_040009
XR_001745530
XM_005273491
XP_005273548
XM_005273496
XP_005273553
XM_005273493
XP_005273550
XM_005273498
XP_005273555
NM_001190720
NP_001177649
NM_001556
NP_001547
NM_001242778
NP_001229707
XM_011544518
XP_011542820
XM_005273492
XP_005273549
XM_005273490
XP_005273547
XM_005273494
XP_005273551
XM_017013396
XP_016868885
XM_011544521
XP_011542823
XM_011544522
XP_011542824
XM_005273495
XP_005273552
XM_011544517
XP_011542819
XM_011544520
XP_011542822
XM_011544519
XP_011542821
NG_041793
AC083973
AY663108
AAT65965
CH471080
EAW63222
EAW63223
EAW63224
EAW63225
EAW63226
KF458748
KF495673
AB209090
BAD92327
AF029684
AAC51860
AF031416
AAC64675
AF080158
AAD08997
AI379342
AK091090
AK091297
BAG52329
AK093537
AK095687
AK097828
AK290952
BAF83641
AK298241
BAG60507
AK302723
BAG63942
AK303294
BAG64369
AK303528
BAG64556
AK316418
BAH14789
AL708460
BC006231
AAH06231
BC090865
BC108694
AAI08695
BC127663
AAI27664
BC141978
AAI41979
BC144080
BX648165
DA043516
DA105584
DA159382
DA709000
O14920
NC_000074
NM_001159774
NP_001153246
NM_010546
NP_034676
XM_006509019
XP_006509082
XM_006509020
XP_006509083
XM_006509021
XP_006509084
XM_006509022
XP_006509085
XM_006509023
XP_006509086
AC121835
CH466580
EDL32880
EDL32881
AA203913
AF026524
AAC23557
AF088910
AAD52095
AK003927
AK011359
BAE43224
AK051128
BAC34533
AK053346
AK086442
AK139972
BAE24202
AK144048
AK144603
BAE25962
AK150884
BAE29931
AK151888
AK151955
BAE30827
AK153151
BAE31761
AK155587
AK156294
BAE33659
AK172275
BAE42920
AK177348
AK182153
AK186184
AK194273
AK201390
AK219506
BC004772
AAH04772
BC019210
BC020334
BC037723
AAH37723
BY015258
O88351
NC_005115
NM_053355
NP_445807
AC_000084
AABR07026361
AAHX01088838
AAHX01088839
AAHX01088840
CH473970
EDM09011
EDM09012
AF115282
AAF21978
CB810812
CO383061
Q9QY78
XM_005273500
XR_870200
AABR06089167
ABBA01021152
ABBA01021153
AMYH02017890
AC_000030
AC_000140
AAHY01068478
AAHY01068479
XP_005273556
XP_005273557
XP_005273554
NC_018919
XM_005273497
XM_005273499
NR_033820
NM_001190722
NP_001177651
NM_001190721
NP_001177650
NT_167187
NW_001839130
NW_923907
AC_000051
CR607076
Q32ND9
Q59GL9
NT_039457
NW_001030892
Q05DR8
Q3U141
Q3USX8
Q3V454
Q5D0E0
Q8BQA9
NW_047475
NW_001084719

Swiss-Prot ID IKKB_HUMAN
IKKB_MOUSE
IKKB_RAT
Q32ND9_HUMAN
B4DP95_HUMAN
B4DZ30_HUMAN
E9PH46_HUMAN
Q5D0E0_MOUSE

Cell Localization Cytoplasm
Nucleus
Membrane raft

Ensembl ID ENSG00000104365
ENSP00000404920.3
ENST00000416505.6
ENSP00000430684.1
ENST00000520810.6
ENST00000342222.6
ENST00000629753.1
ENSP00000428186.1
ENST00000521661.5
ENSMUSG00000031537
ENSMUSP00000033939.6
ENSMUST00000033939.12
ENSMUSP00000064235.3
ENSMUST00000063401.9
ENSMUSP00000138378.1
ENSMUST00000135326.7
ENSRNOG00000019073
ENSRNOP00000025851.2
ENSRNOT00000025851.4
ENST00000629753
ENSMUST00000125314
ENST00000416505
ENSP00000430868
ENST00000521661
ENST00000520810
ENSP00000404920.2
ENSP00000430868.1
ENST00000520835
ENST00000342222
ENSMUSP00000138378
ENST00000416505.5
ENST00000520810.5
ENSP00000430684
ENST00000520835.5
ENSP00000404920
ENSRNOP00000025851
ENSMUST00000135326
ENSRNOT00000025851
ENSP00000428186
ENSMUST00000033939
ENSMUST00000063401
ENSMUSP00000033939
ENSMUSP00000064235

MGI ID MGI:1338071
1338071

RGD ID 621375

Unigene ID Rn.19222
Mm.277886
Hs.597664

Homologene ID 7782

Shape Sickle-vertex

IPI ID IPI00213608
IPI00024709
IPI00798101
IPI00982033
IPI00130038
IPI01010552
IPI00656051
IPI00981929
IPI00556772
IPI00556516
IPI00796308
IPI00789633
IPI00654351
IPI00653754
IPI00458320
IPI00830374
IPI00831429
IPI00782738