Protein RASGRP1

URN urn:agi-llid:10125
Total Entities 0
Connectivity 525
Name RASGRP1
Description RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Notes This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm

Pathway High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
Dopamine Receptors Signaling
Serotonin Receptors Signaling
CRH Secretion Regulation
Prolactin Production
Mineralcorticoids Secretion Regulation
Plasmin Effects in Inflammation
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Nociception Expression Targets Signaling
Vascular Motility
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA2C/ADRB2 -> Vasoconstriction
ADRA2C/ADRB2 -> Synaptic Endocytosis
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
CHRNA7 -> NOS1 Production
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
P2RY11/13/14 -> IL8/10 Production
Luteinizing Hormone in Oocyte Meiotic Resumption
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Endothelin Signaling in Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Contraction Due Vasospasm
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Prolactinoma Overiew
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Hodgkin Lymphoma
T-Cell Acute Lymphoblastic Leukemia
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
EGFR and PTAFR Signaling in Ovarian Cancer
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
VEGFA in Neovascular Glaucoma
PGF2-alpha Effect on Treatment
Plasmin Role in Glomerulonephritis
Sertoli Cells Dysfunction Causes Male Infertility
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CHRNA7 -> CREB Signaling
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
CD19 -> JUN/ELK Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL16 -> AP-1 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
PGE1 Expression Targets
Elevated Receptors -> Expression Targets in Lymph Node
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
AMPK Signaling
AXL Receptor Tyrosine Kinase Signaling
KRAS Signaling
HRAS Signaling
TCR -> AP-1 Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
ROS in Triggering Vascular Inflammation
ROS and RNS in Vasoconstriction and Vasodilation Regulation
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
2_Cardiomyocyte hypertrophy
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
4_1_Airway smooth muscle cells contraction
public list
KRAS->RAFs->MAPK1/3
NRAS->RAFs->MAPK1/3

Group Genes with Mutations Associated with Osteopetrosis

MedScan ID 10125

LocusLink ID 10125
19419
29434

Alias Rasgrp I
CALDAG-GEFI
CALDAG-GEFII
MGC129998
RAS guanyl nucleotide-releasing protein 1
RAS guanyl releasing protein 1
MGC129999
Rasgrp1
RP23-73I19.3
RASGRP
OTTMUSP00000016207
RAS guanyl releasing protein I
hRasGRP1
CalDAG-GEF1
calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II
Calcium and DAG-regulated guanine nucleotide exchange factor II
guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl nucleotide-releasing protein I
ras activator RasGRP
RAS guanyl-releasing protein 1
V

GO ID 0005088
0005509
0019992
0005085
0008289
0031210
0001786
0042803
0008270
0000165
0007265
0090630
0030154
0001816
0002437
0043303
0070374
0043547
0046330
0043406
0046579
0033089
0032725
1902715
0032825
0045954
0001934
0032760
0051259
0070372
1900744
0014066
1900274
0032252
0007165
0047496
0005794
0000139
0005829
0005789
0042629
0016020
0005886
0046872
0035556
0032816
0007264
0005737
0005783
0005096
0017034
0043087
0038095
0032862
0007596
0045087
0030168
0032856
0051056
0005623
0005622
0032854

KEGG ID rno:29434
hsa:10125
mmu:19419

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 2 59.19 cM

OMIM ID 603962

Rat chromosome position 3q35
3q34-q35

Hugo ID 9878
HGNC:9878

Human chromosome position 15q14

Swiss-Prot Accession B2RA89
O95267
O95267.2
Q9Z1S3
Q9Z1S3.1
Q9R1K8
Q9R1K8.1
O88469
Q56CZ0
Q58G75
Q59HB1
Q5I3A8
Q6GV31
Q6NX39
Q7LDG6
Q9UI94
Q9UNN9
Q3URH0
Q3V401
Q8BQP6
F5H514

GenBank ID NC_000015
XM_017021860
XP_016877349
XM_005254114
XP_005254171
XM_011521151
XP_011519453
NM_001306086
NP_001293015
NM_001128602
NP_001122074
NM_005739
NP_005730
NG_023268
AC116158
AC124306
CH471125
EAW92372
KF456047
AA742351
AB208848
BAD92085
AF081195
AAC79699
AF081197
AAF21898
AF106071
AAC97349
AK295097
BAG58133
AK314091
BAG36786
AK316067
BAH14438
AY634315
AAT47482
AY858556
AAW32406
AY954625
AAX54699
AY966005
AAX76907
BC032849
BC067298
AAH67298
BC109296
AAI09297
BC109297
AAI09298
BU431038
DA993002
O95267
NC_000068
NM_011246
NP_035376
AL844579
AL928959
CH466519
EDL27897
AF106070
AAC97348
AK013548
AK028308
BAE20439
AK047613
BAC33100
AK134005
AK141524
BAE24718
BC057120
AAH57120
BC057341
AAH57341
BE991595
Q9Z1S3
NC_005102
NM_019211
NP_062084
AC_000071
AABR07053473
AAHX01024503
AAHX01024504
CH473949
EDL79846
AF060819
AAC40137
AF081196
AAC79700
Q9R1K8
XM_011521152
XP_011519454
XR_931740
XM_011521154
XP_011519456
XM_011521153
XP_011519455
NC_018926
AMYH02030216
EU832766
ACE87777
GQ129309
ACT64443
AC_000024
AAHY01019867
AAHY01019868
AAHY01019869
AAHY01019870
AAHY01019871
AAHY01019872
AC_000147
ABBA01038478
ABBA01038479
XM_005254113
XP_005254170
XM_005254116
XP_005254173
XM_005254115
XP_005254172
AABR06025722
AABR06025723
AABR06025724

Swiss-Prot ID GRP1_RAT
GRP1_HUMAN
GRP1_MOUSE

Cell Localization Cytoplasm
Cytosol
Cell membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol

Ensembl ID ENSG00000172575
ENSP00000388540.2
ENST00000450598.6
ENSP00000452721.1
ENST00000559830.5
ENSP00000310244.5
ENST00000310803.10
ENSP00000453583.1
ENST00000558432.5
ENSMUSG00000027347
ENSMUSP00000099593.4
ENSMUST00000102534.10
ENSRNOG00000005404
ENSRNOP00000007687.4
ENSRNOT00000007687.4
ENSP00000388540
ENST00000450598
ENSP00000310244
ENST00000310803
ENSP00000452721
ENST00000559830
ENSP00000413105
ENST00000414708
ENSMUSP00000099593
ENSMUST00000102534
ENSRNOP00000007687
ENSRNOT00000007687

MGI ID MGI:1314635
1314635

RGD ID 3539

Unigene ID Hs.591127
Mm.42150
Rn.162685

Homologene ID 4195

Shape Stick-vertex