Protein MYD88

URN urn:agi-llid:4615
Total Entities 0
Connectivity 3523
Name MYD88
Description myeloid differentiation primary response 88
Notes This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Primary Cell Localization Cytoplasm
Class Receptor
ObjectType Protein

Pathway Osteoarthritis
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Toll-like Receptors Act through MYD88-TIRAP Signaling
Antiviral Signaling through Pattern Recognition Receptors
Toll-like Receptors Act through MYD88 Signaling
TLR4 Signaling in Leukocytes
Dectin-2 (CLEC6A)/Mincle (CLEC4E)/BDCA2 (CLEC4C) Signaling
Th1-Cell Differentiation
Th17-Cell Differentiation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
IL1B Expression Targets -> Nociception
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Low-Density Lipoproteins and Chemokines in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Myocardial Infarction
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
Proteins Involved in Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Insulin Resistance in Myocytes Induced by Obesity
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
Celiac Disease
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Proteins Involved in Hodgkin Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Splenic Marginal Zone Lymphoma
Antiphospholipid Antibodies and Endothelial Cell Interaction
IL33 Signaling Related Eosinophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Th17-Cell Numbers Reduction in HIV
Toll-like Receptors (TLR) in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Microglia Activation in Alzheimer's Disease
HMGB1 and IL1B in Neuroinflammation
HMGB1 and IL1B in Neuronal Hyperexcitation
Microglia Activation in Parkinson's Disease
Proteins Involved in Amyotrophic Lateral Sclerosis
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
IDO1 in Cancer Immune Escape
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
IL21 Expression Targets
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
C5AR1 -> Expression Targets in Lymphoid System and Blood
NF-kB Canonical Signaling
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR4 -> IRF Signaling
TLR4/5/7/9 -> NF-kB Signaling
TLR1/2/6 -> NF-kB Signaling
TLR -> AP-1 Signaling
pathway 4
PPAR Psoriasis
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
sars-cov no binding
dsRNA induces innate immunity and INFs in alveolar cells
Innate immunity in Leukocytes
AGER feed forward loop in innate immunity
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
1_Low-density lipoprotein internalization and the accumulation of lipids in atherosclerosis
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
4_3_Insulin resistance: FFA-related insulin resistance
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
drug-target pairs direct regulation
Model of PPARG signaling in psoriais (tested)
mapk1 direct regulators
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atopic Dermatitis
Genes with Mutations Associated with Splenic Marginal Zone Lymphoma
other partners for SARS

MedScan ID 4615

LocusLink ID 4615
17874
301059
29638

Alias OTTHUMP00000209060
myeloid differentiation primary response gene (88)
MYD88
MYD88, innate immune signal transduction adaptor
myeloid differentiation factor 88
Myeloid differentiation primary response protein MyD88
Myeloid differentiating primary response protein MyD88
OTTMUSP00000018013
myeloid differentiation protein 88
myeloid differentiation marker 88
OTTHUMP00000208595
myeloid differentiating primary response gene (88)
MYD88D
mutant myeloid differentiation primary response 88
myeloid differentiation primary response 88
myeloid differentiation primary response protein 88
myeloid differentiation primary response gene 88

GO ID 0070976
0035325
0005123
0043621
0070935
0002755
0008063
0006915
0007166
0071260
0140052
0050830
0042742
0006954
0045087
0070498
0043066
0006909
0043123
0051092
1900017
0010628
0032740
0032747
0032755
0032757
0032481
0050727
0070555
0007165
0034162
0002224
0060337
0005737
0005829
0010008
0005634
0005886
0005121
0005149
0005102
0007254
0019221
0090557
0006955
0002376
0016064
0009682
0031663
0044130
0046330
0045080
0050671
0048661
0032760
0042127
2000338
2000341
0010468
0032675
1902622
0032680
0032496
0002238
0032494
0009615
0007178
0045351
0014069
0032991
0005622
0034146
0006916
0034142
0005515
0034134
0034130
0043234
0048011
0034166
0038123
0045944
0038124
0042802
0004888
0031224
0007249
0004871
0016020
0042535

KEGG ID hsa:4615
mmu:17874
rno:301059

MedLine Reference 10383454
10854325
10880445
10952994
11544529
11743586
11828002
11854210
11880380
11909531
11960013
12391239
12477932
12531807
12646618
12659850
12724322
12761501
12860405
12865424
12885415
14573621
14630816
14702039
15004556
15342556
15361868
15489334
15623538
15665823
15728506
15760459
15845500
15849357
16189514
16203735
16236719
16286016
16293622
16365431
16424162
16482509
16517734
16517750
16644730
17363736
17507480
17513785
8957090
9013863
9344657
9374458
9716450
10047546
10349636
10435584
10465784
10607756
10922068
11025209
11042159
11067888
11076861
11217851
11286707
11313410
11500829
11521059
11526399
11698470
11739528
11823477
11911827
11923871
12055206
12218091
12244183
12244184
12244198
12270723
12447442
12466851
12538665
12559494
12626561
12682257
12695520
12714520
12719478
12750407
12819136
12847214
12855817
12872135
12874236
12902324
12917260
12928382
12933875
12960345
14517275
14530329
14563635
14568952
14579265
14625548
14634130
14636418
14638820
14638995
14668429
14670305
14698224
14716310
14734753
14742526
14742577
14744795
14764662
14768061
14971048
14976261
14993594
15004134
15004140
15034058
15034062
15034070
15034168
15034566
15039335
15039368
15067049
15128790
15128822
15128825
15137944
15153511
15155621
15190057
15197227
15214027
15240744
15249654
15258598
15260992
15265925
15265935
15302901
15307830
15322035
15322195
15331330
15345224
15353553
15368304
15375173
15452235
15492225
15507117
15517610
15534227
15539158
15542452
15593126
15599404
15606799
15611251
15615857
15618166
15630134
15634894
15650773
15650774
15654326
15654341
15661931
15671286
15694359
15709004
15709016
15711573
15714580
15723296
15724245
15731053
15731095
15765149
15778492
15781585
15782199
15800576
15814710
15814731
15815647
15826931
15845454
15855642
15890912
15895089
15905587
15922717
15944297
15956283
15964841
15972526
15972679
16002681
16002682
16002720
16025156
16039576
16040976
16041030
16041408
16047338
16052598
16081822
16116197
16116224
16141072
16141073
16142239
16148103
16148139
16148144
16204620
16207247
16210631
16216974
16226506
16236128
16237045
16237098
16237099
16239556
16244651
16254214
16260486
16272281
16272328
16272344
16275884
16276483
16292312
16301743
16323245
16339557
16365150
16369011
16401773
16407889
16413925
16413926
16413927
16424940
16428431
16428731
16440059
16456012
16456013
16461338
16461893
16473828
16473830
16477040
16491077
16495516
16513388
16518342
16552045
16552075
16554296
16574902
16609927
16648192
16670325
16670327
16703513
16703567
16709840
16710369
16714560
16714586
16714594
16732281
16777969
16782034
16782035
16785556
16829620
16832055
16874736
16878177
16879997
16886064
16888020
16892068
16893899
16921381
16926427
16935388
16951362
16954198
16955143
16980981
16983331
16990136
17000122
17015716
17018642
17027299
17030581
17034585
17038589
17053835
17055754
17057095
17060475
17074859
17085599
17118979
17135446
17159982
17167049
17178920
17178921
17185603
17190817
17194808
17200722
17202381
17267571
17275788
17283089
17289654
17292937
17329566
17339355
17353199
17353291
17353783
17357057
17361131
17372011
17389381
17398124
17404295
17417641
17433728
17442966
17450126
17450144
17452470
17456769
17458858
17469144
17475853
17486093
17496895
17567694
17573354
17576821
17579078
17591966
17615358
17615359
17617634
17638914
17658280
17664289
17668900
17705131
17707128
17723216
2374694
7567467
9575168
9697844
12616494
14962484
15890643
16199478
16259957
16954392

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 9 71.33 cM
9 70.0 cM

OMIM ID 602170
612260
153600

Rat chromosome position 8q32

Hugo ID 7562
HGNC:7562

Human chromosome position 3p22.2
3p22

Swiss-Prot Accession Q99836.1
P22366
Q3U7M4
P22366.3
Q6Y1S1
Q6Y1S1.2
Q99836
B4DKH8
B4DKU4
B4DQ60
B4DQ72
J3KPU4
J3KQ87
J3KQJ6
P78397
Q53XS7
O35916
Q4QRC0
A0A0A0MSI9
A0A0A0MS70
A0A0A0MST0
Q0PM15
Q0PM16
Q3TIB3
Q3U6W5
Q3UDG9
Q8C1X0

PIR ID S11226

GenBank ID NC_000003
NM_001172567
NP_001166038
NM_002468
NP_002459
NM_001365876
NP_001352805
NM_001172569
NP_001166040
NM_001172568
NP_001166039
NM_001365877
NP_001352806
NM_001172566
NP_001166037
NG_016964
AP006309
CH471055
EAW64520
EAW64521
KU886048
ANN25047
KX098585
ANK58152
KX138263
ANK58154
KX138264
ANK58155
KX138265
ANK58156
AB446470
BAG55247
AK097983
AK124685
AK296570
BAG59190
AK296716
BAG59306
AK298650
BAG60822
AK298666
BAG60834
AK300051
BAG61860
AK300448
BAG62170
AK304676
BAG65448
AL832906
BC013589
AAH13589
BP242808
BP339466
BT007376
AAP36040
BX537602
DA040090
DC350705
U70451
AAB49967
U84408
AAC50954
Q99836
NC_000075
NM_010851
NP_034981
AC128702
CH466587
EDL09224
EDL09225
EDL09226
U89023
AAB83958
X86457
AK090107
BAC41096
AK150083
BAE29292
AK151748
BAE30658
AK152596
BAE31345
AK152935
BAE31609
AK167929
BAE39933
AK186240
AK217564
BC005591
AAH05591
BC051075
BC058787
AAH58787
DQ790885
ABG78743
DQ790886
ABG78744
KY130516
AQQ13080
KY130517
AQQ13081
U84409
AAC53013
X51397
CAA35762
P22366
NC_005107
XM_006244087
XP_006244149
NM_198130
NP_937763
AC_000076
AABR07073459
AAHX01057527
CH473954
EDL76917
AY191270
AAO91937
BC097266
AAH97266
Q6Y1S1
XP_006713233
XM_006713170
XP_005265229
XM_005265172
AAHY01082338
ABBA01024827
ACE86707
EU831951
AC_000031
AC_000135
NC_018914
AABR06057556
ACE87392
EU832045
AMYH02006564
NT_022517
NW_001838877
NW_921651
NG_023225
AC_000046
CR619528
NT_039482
NW_001030922
Q0PM15
Q0PM16
Q3TIB3
Q3U6W5
Q3U7M4
Q3UDG9
Q8C1X0
NW_001084876
NW_047803
Q4QRC0
Q53XS7
119584924
119584925
15488923
1763091
1814020
18202671
21757899
30583591
74727050
74728522
BAC05209
Q8N1J2
110618125
110618127
123782666
123785987
123786657
123787636
123787794
123797080
13542775
148677277
148677278
148677279
1814022
20141515
2459632
26354939
37589152
53294
74198869
74204359
74211897
74220746
74225359
81876106
BG072146
BG084982
149018276
32732698
67678198
81870890
81918231

Swiss-Prot ID MYD88_HUMAN
MYD88_MOUSE
MYD88_RAT
B4DQ60_HUMAN
B4DQ72_HUMAN
Q3U7M4_MOUSE
Q6Y1S1_RAT

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000172936
ENSP00000497991.1
ENST00000650112.1
ENSP00000498321.1
ENST00000652534.1
ENSP00000401399.3
ENST00000417037.7
ENSP00000499012.1
ENST00000651800.1
ENSP00000379625.4
ENST00000396334.8
ENSMUSG00000032508
ENSMUSP00000035092.6
ENSMUST00000035092.6
ENSRNOG00000013634
ENSRNOP00000018341.3
ENSRNOT00000018341.5
ENSP00000379625.3
ENST00000495303.5
ENST00000424893.5
ENSP00000390565.2
ENST00000417037.6
ENSP00000417848.1
ENST00000443433.6
ENSP00000389979.1
ENST00000396334.7
ENSP00000401399.2
ENSP00000390565
ENSMUST00000035092
ENST00000417037
ENSP00000417848
ENSP00000379625
ENSMUSP00000035092
ENSRNOT00000018341
ENSP00000389979
ENST00000495303
ENSRNOP00000018341
ENSP00000401399
ENST00000443433
ENST00000424893
ENST00000396334

MGI ID MGI:108005
108005

RGD ID 735043

Unigene ID Hs.82116
Mm.213003
Rn.37341

Homologene ID 1849

IPI ID IPI00909842
IPI00400691
IPI00127375
IPI00878858
IPI00925056
IPI00955716
IPI00924787
IPI00910972
IPI00883933
IPI00798074
IPI00793815
IPI00001062
IPI00796856
IPI00754505

Homo sapiens Chromosome position 3p22

Ensembl Transcript ID ENST00000396334
ENST00000424893
ENST00000495303
ENST00000443433
ENST00000421516

FunctionalClass death receptor binding
protein binding
signal transducer
transmembrane receptor
Toll binding
receptor binding

Mus musculus Chromosome position 9 70.0 cM

KEGG pathway Apoptosis
Toll-like receptor signaling pathway

Rattus norvegicus Chromosome position 8q32

Ensembl Gene ID LRG_157
ENSG00000172936