URN | urn:agi-llid:3460 |
---|---|
Total Entities | 0 |
Connectivity | 282 |
Name | IFNGR2 |
Description | interferon gamma receptor 2 (interferon gamma transducer 1) |
Notes | This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
ObjectType | Protein |
Pathway | Natural Killer Cell Activation |
---|---|
T-Cell Cytotoxic Mediated Cell Death | |
Th1-Cell Differentiation | |
Proplatelet Maturation | |
Macrophage M1 Lineage | |
AHR Signaling in M1 Macrophages Function | |
Th1-Cells Activation and Proliferation in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
SOCS in Negative Feedback Regulation in Myocarditis | |
Atopic Dermatitis | |
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis | |
Th1-Cell Function in Systemic Lupus Erythematosus | |
Vitiligo | |
T-Cell Cytotoxic Response against Melanocytes in Vitiligo | |
Toll-like Receptors in beta-Cell | |
beta-Cell Destruction through Cytokines in Diabetes Mellitus | |
beta-Cell Destruction in Diabetes Mellitus Type 1 | |
Hashimoto's Thyroiditis | |
CD4+T-Cell Response in Celiac Disease | |
Metastatic Colorectal Cancer | |
Keratinocyte Activation in Psoriatic Arthritis | |
IFNG -> ARRB1/STAT1 Signaling | |
Clozapine Induced Granulocytopenia | |
Myeloid Derived Suppressor Cells in Cancer Immune Escape | |
IDO1 in Cancer Immune Escape | |
IFNG/IFNR Expression Targets | |
IFN signaling in alveolar cells | |
1_Differentiation of psoriatic T cells | |
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
Differentiation of psoriatic T cells |
MedScan ID | 3460 |
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LocusLink ID | 3460 |
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15980 | |
360697 |
Alias | AF I |
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IFNGT1 | |
IFNGT I | |
interferon gamma receptor accessory factor-1 | |
IFN gamma receptor II | |
IFN gamma receptor 2 | |
Interferon-gamma receptor accessory factor I | |
interferon gamma receptor 2 (interferon gamma transducer 1) | |
IFGR2 | |
Interferon-gamma transducer I | |
IFN-gamma-R-beta | |
OTTHUMP00000067751 | |
IFN gamma R2 | |
interferon gamma receptor 2 | |
Ifngr2 | |
interferon gamma receptor II | |
Interferon-gamma transducer-1 | |
interferon gamma receptor beta chain | |
Ifgt | |
AF-1 transducer | |
AF-1 | |
IMD28 | |
IFN-gamma receptor 2 | |
IFN-gamma-R2 | |
interferon gamma transducer 1 | |
interferon gamma receptor accessory factor 1 | |
Ifngr2_predicted |
GO ID | 0004896 |
---|---|
0004906 | |
0007166 | |
0019221 | |
0060333 | |
0060334 | |
0009615 | |
0000139 | |
0030659 | |
0005783 | |
0005789 | |
0005887 | |
0005886 | |
0051607 | |
0001774 | |
1904783 | |
0016021 | |
0004872 | |
0007165 |
KEGG ID | hsa:3460 |
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rno:360697 | |
mmu:15980 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 16 53.07 cM |
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16 63.3 cM |
OMIM ID | 147569 |
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614889 | |
209950 |
Rat chromosome position | 11q11 |
---|
Hugo ID | 5440 |
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HGNC:5440 |
Human chromosome position | 21q22.11 |
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Swiss-Prot Accession | E7EUY1 |
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A8K881 | |
P38484 | |
P38484.2 | |
Q63953 | |
D4A109 | |
Q9BTL5 | |
Q3UVK9 | |
Q8C352 |
PIR ID | I38500 |
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A49947 |
Swiss-Prot ID | INGR2_HUMAN |
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A8K881_HUMAN | |
Q63953_MOUSE | |
D4A109_RAT |
Cell Localization | Cell membrane |
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Cytoplasmic vesicle membrane | |
Golgi apparatus membrane | |
Endoplasmic reticulum membrane | |
Cytoplasm | |
Membrane | |
Plasma membrane |
Ensembl ID | ENSG00000159128 |
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ENSP00000371425.1 | |
ENST00000381995.5 | |
ENSP00000290219.5 | |
ENST00000290219.10 | |
ENSMUSG00000022965 | |
ENSMUSP00000023687.7 | |
ENSMUST00000023687.8 | |
ENSRNOG00000002032 | |
ENSRNOP00000002779.5 | |
ENSRNOT00000002779.5 | |
ENSRNOP00000002779 | |
ENSMUST00000023687.7 | |
ENST00000381995 | |
ENSMUSP00000023687 | |
ENSMUST00000023687 | |
ENSP00000371425 | |
ENST00000290219 | |
ENSP00000290219 | |
ENSRNOT00000002779 |
MGI ID | MGI:107654 |
---|---|
107654 |
RGD ID | 1307532 |
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Unigene ID | Hs.634632 |
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Rn.23305 | |
Mm.249364 |
Homologene ID | 4041 |
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Shape | Stick-vertex |
---|
IPI ID | IPI00221193 |
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IPI00135751 | |
IPI00373039 | |
IPI00658181 | |
IPI00878832 | |
IPI00893563 | |
IPI00894187 | |
IPI00893797 |