Protein IL21

URN urn:agi-llid:59067
Total Entities 0
Connectivity 2370
Name IL21
Description interleukin 21
Notes This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Primary Cell Localization Extracellular
Class Ligand

Pathway Melatonin Effects on Circadian Cycle
Immunoglobulin Genes Transcriptional Activation
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
IL6 Expression Targets -> Nociception
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Celiac Disease
CD4+T-Cell Response in Celiac Disease
Proteins with Altered Expression in Celiac Disease
Celiac Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Helicobacter Infections
Proteins Involved in Diffuse Large-B-Cell Lymphoma
Follicular Lymphoma
Hodgkin Lymphoma
Hodgkin and Reed-Sternberg Cells Reprogramming
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Proteins Involved in Rheumatoid Arthritis
Th17-Cell Numbers Reduction in HIV
IL21R -> STAT Signaling
IL21 Expression Targets
CD40 -> Expression Targets in Thymus
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of body weight
Neighbors of neutrophil count
Neighbors of exhaustion
Neighbors of apoptosis rate
Neighbors of viral load
Neighbors of blood pressure
Neighbors of vascular leakage
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of radiosensitivity
Neighbors of functional status
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of body weight
Neighbors of neutrophil count
Neighbors of exhaustion
Neighbors of apoptosis rate
Neighbors of viral load
Neighbors of blood pressure
Neighbors of vascular leakage
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of radiosensitivity
Neighbors of functional status
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of lumen formation
Neighbors of cell damage
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of autophagy
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of cell transdifferentiation
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of hyperplasia
Neighbors of liver fibrosis
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of infection
Neighbors of preeclampsia
Neighbors of liver injury
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of kidney disease
Neighbors of pulmonary fibrosis
Neighbors of stroke
Neighbors of cancer
Neighbors of neoplasm
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of respiratory hypersensitivity
Neighbors of synovitis
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of ovarian cancer
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of monocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of fibroblast
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of microglia
Neighbors of mononuclear cell
Neighbors of dendritic cell
Neighbors of neutrophil
Neighbors of activated T-cell
Neighbors of immunocompetent cell
Neighbors of myeloid cell
Neighbors of stem cell
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of mast cell
Neighbors of spleen cell
Neighbors of hematopoietic cell
Neighbors of antigen-presenting cell
Neighbors of bone marrow derived mast cell
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of synovial membrane
Neighbors of brain
Neighbors of artery
Neighbors of lymphatic system
Neighbors of immune system
Neighbors of spleen
Neighbors of eye
Neighbors of lymph node of mesentery
Neighbors of thymus gland
Neighbors of draining lymph node
Neighbors of mediastinal lymph node group
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of IL1 family
Neighbors of Jun/Fos
Neighbors of PI3K
Neighbors of STAT family
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of cytokine
Neighbors of interleukin
Neighbors of ovalbumin
Neighbors of NF-AT family
Neighbors of LXR
Neighbors of IL23
Neighbors of T-cell receptor
Neighbors of IL12
Neighbors of mitogen-activated protein kinase kinase
Neighbors of PP2B
Neighbors of AHR subfamily
Neighbors of CD3 complex
Neighbors of Rho kinase
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
1_Differentiation of psoriatic T cells
4_1_Polymorphisms associated with inflammatory bowel diseases
1_CD4+ T cell and epithelial cell response in celiac disease
Model of PPARG signaling in psoriais (tested)
Differentiation of psoriatic T cells

Group Genes Associated with Systemic Lupus Erythematosus
Genes Associated with Ulcerative Colitis
Genes with Mutations Associated with Ulcerative Colitis
Genes with Mutations Associated with Psoriatic Arthritis

MedScan ID 59067

LocusLink ID 59067
60505
365769

Alias interleukin 21
interleukin-21 receptor ligand
DN-452A22.7
OTTMUSP00000007838
IL21
interleukin-21 receptor ligand activity
Interleukin IL21
interleukin-21 receptor ligands
LOC547223
CVID-11
Za11
LOC194131
CVID11
IL-21
interleukin-21 isoform
interleukin-21

GO ID 0005125
0005126
0005134
0048469
0006955
0038114
0030890
0042102
0008284
0001819
0050729
0045078
0032740
0045954
0034105
0042531
0007165
0007260
0005576
0005615
0001783
0045579
0032733
0002729
0032825
0010469
0005622
0042511
0042517
0042503

KEGG ID hsa:59067
mmu:60505
rno:365769

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 3

OMIM ID 605384
615767

Rat chromosome position 2q25

Hugo ID 6005
HGNC:6005

Human chromosome position 4q27
4q26-q27

Swiss-Prot Accession Q9HBE4
A0A224B028
Q9HBE4.3
E9PX58
Q5SUE2
Q9ES17
Q9ES17.1
A3QPB9
A3QPB9.1
A5J0L4
Q9HBE4.2

GenBank ID NC_000004
NM_021803
NP_068575
NM_001207006
NP_001193935
NG_031966
AC053545
AY763518
AAU88182
CH471056
EAX05226
CS080568
CAI94500
CS237090
CAJ47524
CS450761
CAL81203
CS582814
CAN87399
FB677173
CAS03522
GM619752
CAV33288
HB976773
CBE74752
HC196689
CBI70418
HC203173
CBI85469
HC203434
CBI85472
HC686913
CBL93962
JA104585
CCA63962
AF254069
AAG29348
BC066258
AAH66258
BC066259
AAH66259
BC066260
AAH66260
BC066261
AAH66261
BC066262
AAH66262
BC069124
AAH69124
CD559460
CD559613
DQ645417
ABG36529
LC133256
BBA22643
Q9HBE4
NC_000069
NM_021782
NP_068554
NM_001291041
NP_001277970
NT_039248
NT_039252
AL645807
AL645966
AL645982
AL662823
CH466530
EDL35100
AF254070
AAG29349
AK155984
AY428162
AAR06254
BC125414
AAI25415
BC125416
AAI25417
DQ645418
ABG36530
Q9ES17
NC_005101
NM_001108943
NP_001102413
AC_000070
AABR07010109
AAHX01016352
AAHX01016353
CH473961
EDM01297
HB976777
CBE74756
DQ387062
ABD52001
A3QPB9
NC_018915
AMYH02010018
HQ447458
ADQ31944
AC_000025
AAHY01025628
AC_000136
ABBA01044738
ABBA01044739
XM_006535513
XP_006535576
CAM28076
CAI26234
CAM18421
NT_016354
NW_922217
NW_001838920
AC_000047
NT_162143
NW_001030719
Q5SUE2
NW_047625
NW_001084800
XM_001479075
XP_001479125
XM_622579
XP_622579

Swiss-Prot ID IL21_HUMAN
IL21_MOUSE
IL21_RAT
Q5SUE2_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000138684
ENSP00000477555.1
ENST00000611104.2
ENSP00000497915.1
ENST00000648588.1
ENSMUSG00000027718
ENSMUSP00000124668.1
ENSMUST00000161015.1
ENSMUSP00000029273.1
ENSMUST00000029273.7
ENSRNOG00000017376
ENSRNOP00000023348.4
ENSRNOT00000023348.4
ENST00000264497.7
ENSP00000264497.3
ENST00000611104.1
ENSP00000477555
ENST00000611104
ENSP00000264497
ENST00000264497
ENSMUSP00000124668
ENSMUST00000161015
ENSMUSP00000029273
ENSMUST00000029273
ENSRNOP00000023348
ENSRNOT00000023348

MGI ID MGI:1890474
1890474

RGD ID 1307384

Unigene ID Rn.214949
Mm.157689
Mm.393490
Hs.567559

Homologene ID 11032

Shape Rhomb

IPI ID IPI00029151
IPI00877605
IPI00368229
IPI00112642