Protein IFNAR1

URN urn:agi-llid:3454
Total Entities 0
Connectivity 1196
Name IFNAR1
Description interferon alpha and beta receptor subunit 1
Notes The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Proteins Involved in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
T-Cells Differentiation Block in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Proteins Involved in Systemic Lupus Erythematosus
Th17-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Dendritic Cell Dysfunction in Psoriatic Arthritis
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
IFNW1/IFNR Expression Target
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
AXL Receptor Tyrosine Kinase Signaling
PPAR Psoriasis
New Pathway (3)
dsRNA induces innate immunity and INFs in alveolar cells
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
1_Differentiation of psoriatic T cells
drug-target pairs binding
drug-target pairs direct regulation
Differentiation of psoriatic T cells

MedScan ID 3454

LocusLink ID 3454
15975
288264

Alias INF-alpha receptor
interferon receptor 1
interferon (alpha, beta and omega) receptor
interferon (alpha and beta) receptor I
OTTMUSP00000033798
INF-a receptor
IFRC
cytokine receptor class-II member 1
Infar
interferon alpha/beta receptor 1
human interferon-alpha receptors
Hu-IFN-alphaR1
interferon-alpha receptor I
OTTMUSP00000033797
LOC284829
INF-alpha receptors
INF-a receptors
IFNAR
CRF2-1
IFN-alpha-R1
alpha-type antiviral protein
Ifar
type I interferon receptor 1
interferon (alpha, beta and omega) receptor 1
cytokine receptor family 2 member 1
IFNBR
interferon-beta receptor 1
Ifnar1
IFN-R-1
beta-type antiviral protein
human interferon-alpha receptor
INR1
interferon alpha and beta receptor subunit 1
IFN alpha R
human interferon-alpha receptor (HuIFN-alpha-Rec)
INR1_HUMAN
interferon (alpha, beta and omega) receptor I
HuIFN-alphaR1
interferon-alpha receptor 1
Ifnar I
IFN-alpha-REC
CD118
interferon (alpha and beta) receptor 1
HuIFN-alpha-Rec
Interferon-alpha/beta receptor alpha chain
IFN-R
interferon-beta receptor I
IFN-alpha/beta receptor 1
IFN-alpha/betaR
INR I
AVP
interferon-alpha/beta receptor 1

GO ID 0004896
0019962
0004905
0007259
0035457
0019221
0032496
0009615
0060337
0005887
0005770
0005764
0005886
0004904
0004637
0042110
0051607
0032728
0032729
0050718
0045893
0050730
0045351
0005768
0016021
0016020
0060759
0007166
0060338

KEGG ID hsa:3454
mmu:15975
rno:288264

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 16 52.98 cM
16 63.2 cM

OMIM ID 107450

Rat chromosome position 11q11

Hugo ID 5432
HGNC:5432

Human chromosome position 21q22.11

Swiss-Prot Accession P17181
P17181.3
P33896
P33896.2
D3ZDS9
A0A0G2JXD8
B2R6L9
B4DNT3
D3DSF0
Q53GW9
Q53H11
Q6PKD7
Q7M4L2
Q8WTZ2
Q80UJ3

PIR ID A32694
S41602
A45283

GenBank ID NC_000021
XM_005260964
XP_005261021
XM_011529552
XP_011527854
NM_000629
NP_000620
AF039907
AP000296
AP000297
AP000298
AP001716
AY654286
AAT49100
CH471079
EAX09837
EAX09838
EAX09839
KF510545
X60459
CAA42992
AK123813
AK222770
BAD96490
AK222812
BAD96532
AK298051
BAG60345
AK312631
BAG35516
BC002590
AAH02590
BC014338
BC021825
AAH21825
BC035603
BC065751
BG116121
BG548299
BX537636
CA309858
J03171
AAA52730
JN543953
AFN73226
JN543954
AFN73227
JN543955
AFN73228
JN543956
AFN73229
R15745
P17181
NC_000082
XR_384931
NM_010508
NP_034638
AC132272
AC150035
CH466602
EDL03825
EDL03826
EDL03827
U06237
AAA65003
U06238
AAC01749
U06239
AAA65004
U06240
AAA65005
U06241
AAA65006
U06242
AAA65007
U06244
AAA65008
AK040184
AK132431
BAE21165
AK136950
AK141630
BAE24775
AK148246
BAE28435
AK153583
BAE32110
AK157555
AK178895
AK193062
AK217677
BC043935
AAH43935
BC052217
AAH52217
BC052429
AAH52429
BE955685
CA322032
M89641
AAA37890
P33896
NC_005110
NM_001271316
NP_001258245
NM_001105893
NP_001099363
XM_017597943
XP_017453432
XM_017597942
XP_017453431
AC_000079
AAHX01068280
AAHX01068281
AC120974
CH473989
EDM10721
EDM10722
EDM10723
EDM10724
FQ210936
FQ218374
FQ235261
AAHY01130191
ABM82249
AMYH02037735
AC_000038
DQ891323
AABR06067655
AC_000153
NC_018932
ABBA01057338
ABM85433
DQ894507

Swiss-Prot ID INAR1_HUMAN
INAR1_MOUSE

Cell Localization Cell membrane
Late endosome
Lysosome
Membrane
Plasma membrane

Ensembl ID ENSG00000142166
ENSP00000270139.3
ENST00000270139.8
ENSP00000498654.1
ENST00000652450.1
ENSP00000498491.1
ENST00000652513.1
ENSMUSG00000022967
ENSMUSP00000023689.4
ENSMUST00000023689.10
ENSMUST00000123196.8
ENSRNOG00000028594
ENSRNOP00000031611.5
ENSRNOT00000029985.6
ENSRNOP00000070232.1
ENSRNOT00000091472.1
ENST00000270139.7
ENSRNOP00000070232
ENSMUST00000023689
ENSMUSP00000023689
ENSP00000270139
ENSRNOT00000029985
ENST00000270139
ENSRNOT00000091472
ENSRNOP00000031611

MGI ID MGI:107658
107658

RGD ID 1305399

TCDB ID 8.A.47.2.1

Unigene ID Mm.502
Hs.529400
Rn.105738

Homologene ID 524

Shape Stick-vertex

IPI ID IPI00115420
IPI00877162
IPI00877141
IPI00012877