URN | urn:agi-llid:6009 |
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Total Entities | 0 |
Connectivity | 911 |
Name | RHEB |
Description | Ras homolog enriched in brain |
Notes | This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008] |
ObjectType | Protein |
Pathway | Oncogene Induced Cellular Senescence |
---|---|
DNA Persistent Repair Inhibits mTOR Signaling | |
mTOR Signaling Activation by Fatty Acids and Glucose | |
mTOR Signaling Activation by Amino Acids | |
mTOR Signaling | |
mTOR Signaling Hyperfunction | |
Hypoxia Inhibits mTOR Signaling | |
SIRT1 Signaling in Aging | |
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model) | |
Insulin Influence on Protein Synthesis | |
Insulin Signaling | |
Proteins Involved in Myocardial Ischemia | |
Preconditioning Ischemia | |
Glucocorticoids in Insulin Resistance in Skeletal Muscles | |
Peutz-Jeghers Syndrome | |
Ketogenic Diet Mechanism (Hypothesis) | |
Blood-Brain Barrier Disruption in Epileptiform Disorders | |
mTOR Hyperactivation after Status Epilepticus | |
Angiogenesis in Endometriosis | |
Polycystins Mutation Effects in Cystic Kidney Disease | |
AREG -> HIF1A Expression Targets | |
EGF -> HIF1A Expression Targets | |
EGFR/ERBB2 -> HIF1A Signaling | |
EREG -> HIF1A Expression Target | |
HBEGF -> HIF1A Expression Targets | |
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression | |
TGFB Signaling activation by Blocking of Tumor Suppressors | |
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors | |
HIF1A as Master Regulator of Angiogenesis in Cancer | |
MTOR/TORC in Cancer Cell Motility and Invasion | |
TGFB Family in Epithelial to Mesenchymal Transition in Cancer | |
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells | |
NRG1 -> HIF1A Expression Target | |
Androgen Receptor non-Genomic Signaling | |
TGF-beta Signaling | |
AMPK Signaling | |
mTOR Signaling | |
VEGF Signaling | |
EGFR Signaling | |
TGFA -> HIF1A Expression Targets | |
ace2 | |
Model of PPARG signaling in psoriasis | |
Model of PPARG related pathways in psoriasis (short version) | |
1_Formation of cysts in polycystic kidney disease | |
3_Enhanced angiogenesis in endometriosis | |
2_Neuron and Schwann cell death |
MedScan ID | 6009 |
---|
LocusLink ID | 6009 |
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19744 | |
26954 |
Alias | GTP-binding protein Rheb |
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GTPase Rheb | |
Ras homolog enriched in brain 2 | |
RAS-homolog enriched in brain | |
Rheb guanosine triphosphatase | |
OTTMUSP00000027651 | |
Rhebs | |
Ras homolog enriched in brain II | |
Rheb1 | |
RHEB | |
RHEB2 | |
Rheb GTP binding protein | |
Rheb GTPases | |
Rheb GTPase | |
Ras homologue enriched in brain protein | |
MGC111559 | |
Ras homolog, mTORC1 binding | |
Ras homolog enriched in brain |
GO ID | 0019003 |
---|---|
0005525 | |
0003924 | |
0000287 | |
0019901 | |
0007050 | |
0120163 | |
0032008 | |
0048714 | |
0016241 | |
2000074 | |
0007165 | |
0007264 | |
0000139 | |
0005829 | |
0005789 | |
0070062 | |
0005765 | |
0016020 | |
0005886 | |
0014069 | |
0005681 | |
0046872 | |
0000166 | |
0032006 | |
0099175 | |
0005794 | |
0005737 | |
0030425 | |
0005783 | |
0098978 | |
0043025 | |
0048168 | |
0016236 | |
0015031 | |
0008286 | |
0005622 |
KEGG ID | hsa:6009 |
---|---|
mmu:19744 | |
rno:26954 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 5 |
---|
OMIM ID | 601293 |
---|
Rat chromosome position | 4q11 |
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4 |
Hugo ID | 10011 |
---|---|
HGNC:10011 |
Human chromosome position | 7q36.1 |
---|---|
7q36 |
Swiss-Prot Accession | A0A090N900 |
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Q15382 | |
Q15382.1 | |
Q540E6 | |
Q921J2 | |
Q921J2.1 | |
Q62639 | |
Q62639.1 | |
B3KWN6 | |
D3DX13 | |
Q53Y56 | |
Q99444 |
PIR ID | S68419 |
---|---|
I55401 |
Swiss-Prot ID | RHEB_HUMAN |
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RHEB_MOUSE | |
RHEB_RAT |
Cell Localization | Endomembrane system |
---|---|
Golgi apparatus membrane | |
Cytoplasm | |
Cytosol | |
Endoplasmic reticulum membrane | |
Cytoplasm, cytosol |
Ensembl ID | ENSG00000106615 |
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ENSP00000262187.5 | |
ENST00000262187.10 | |
ENSMUSG00000028945 | |
ENSMUSP00000030787.8 | |
ENSMUST00000030787.8 | |
ENSRNOG00000050578 | |
ENSRNOP00000063915.2 | |
ENSRNOT00000071737.2 | |
ENSP00000262187 | |
ENST00000262187 | |
ENSMUSP00000030787 | |
ENSMUST00000030787 | |
ENSRNOP00000063915 | |
ENSRNOT00000071737 |
MGI ID | MGI:97912 |
---|
RGD ID | 621840 |
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Unigene ID | Hs.283521 |
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Hs.568850 | |
Hs.647068 | |
Mm.319175 | |
Rn.859 |
Homologene ID | 123916 |
---|