Protein IL23R

URN urn:agi-llid:149233
Total Entities 0
Connectivity 790
Name IL23R
Description interleukin 23 receptor
Notes The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Th17-Cell Differentiation
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Psoriasis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Genes with Susceptibility for Crohn's Disease and Ulcerative Colitis
Il17 Signaling Related Neutrophilia in Asthma
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
Genes with Mutations Associated with Psoriatic Arthritis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
IL23R -> STAT3/NF-kB Signaling
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of tumor progression
Neighbors of disease severity
Neighbors of cancer incidence
Neighbors of gastric cancer risk
Neighbors of tumor progression
Neighbors of disease severity
Neighbors of cancer incidence
Neighbors of gastric cancer risk
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of cell function
Neighbors of adaptive immune response
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of cell transdifferentiation
Neighbors of cell growth
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cell differentiation
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of inflammation
Neighbors of hyperplasia
Neighbors of myocardial infarction
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of infection
Neighbors of preeclampsia
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of systemic lupus erythematosus
Neighbors of collagen-induced arthritis
Neighbors of kidney disease
Neighbors of stroke
Neighbors of cancer
Neighbors of neoplasm
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of ovarian cancer
Neighbors of lung
Neighbors of skin
Neighbors of intestine
Neighbors of colon
Neighbors of breast
Neighbors of stomach
Neighbors of ileum
Neighbors of oxidized LDL
Neighbors of IL1 family
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of JAK
Neighbors of LXR
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of T-cell receptor
Neighbors of IL1R
Neighbors of IL12
Neighbors of Notch
Neighbors of NOS
Neighbors of RA receptor
Overview. Diseases of the skin (chapter 11)
Overview. Diseases of the digestive system (chapter 10)
1_Differentiation of psoriatic T cells
4_1_Polymorphisms associated with inflammatory bowel diseases
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Psoriasis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Graves Ophthalmopathy
Genes with Mutations Associated with Inflammatory Bowel Diseases
Genes Associated with Ulcerative Colitis
Genes with Mutations Associated with Psoriatic Arthritis

MedScan ID 149233
654295

LocusLink ID 149233
209590
689932
100364993

Alias interleukin-23 receptor
IL-23R
OTTHUMP00000010660
OTTMUSP00000038453
LOC100364993
interleukin IL23R
LOC683816
IL23 receptor
interleukin-23R
LOC100912239
interleukin IL23 receptor
IL-23 receptor
interleukin 23 receptor-like
interleukin 23 receptor; interleukin-23 receptor
interleukin 23 receptor
IL23R

GO ID 0019955
0004896
0005143
0042019
0042020
0019221
0050829
0006954
0038155
0032693
0051135
0001916
0042102
0002827
2000330
2000318
0042104
0010536
0002230
0032725
0032729
0032735
0032740
0043382
0032819
0045672
0042531
0042509
0034341
0032496
0009897
0072536
0005886
0043235
0007259
0002376
0045087
0002443
0016021
0005887
0016020
0010535
0042517
0042520
0042523
0042510
0004872
0007165
0005622

KEGG ID hsa:149233
mmu:209590
rno:689932

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 6

OMIM ID 607562
612261
605606
177900
266600

Rat chromosome position 4q31

Hugo ID 19100
HGNC:19100

Human chromosome position 1p31.3

Swiss-Prot Accession Q5VWK5
Q5VWK5.3
G5E8U4
Q8K4B4
Q8K4B4.1
C9JGX4
Q4VGP1
Q4VGP2
Q4VGP3
Q4VGP4
Q4VGP5
Q4VGP6
Q5VWK7
Q8IW84
Q8NFQ9
Q96AS1

GenBank ID NC_000001
XR_001736993
XM_011540790
XP_011539092
XM_011540791
XP_011539093
NM_144701
NP_653302
XM_005270516
XP_005270573
NG_011498
AB542702
BAJ13471
AL109843
AL389925
CH471059
EAX06501
EAX06502
AF461422
AAM44229
AM990313
CAQ51232
AM990314
CAQ51233
AM990315
CAQ51234
AM990316
CAQ51235
AM990317
CAQ51236
AM990318
CAQ51237
AM990319
CAQ51238
AM990320
CAQ51239
AM990321
CAQ51240
AM990322
CAQ51241
AM990323
CAQ51242
AM990324
CAQ51243
AM990325
CAQ51244
AM990326
CAQ51245
AM990327
CAQ51246
AM990328
CAQ51247
AM990329
CAQ51248
AM990330
CAQ51249
AM990331
CAQ51250
AM990332
CAQ51251
AM990333
CAQ51252
AM990334
CAQ51253
AM990335
CAQ51254
AM990336
CAQ51255
AM990337
CAQ51256
AY937250
AAY18345
AY937251
AAY18346
AY937252
AAY18347
AY937253
AAY18348
AY937254
AAY18349
AY937255
AAY18350
BC016829
AAH16829
BC040720
AAH40720
BC142955
FM212237
CAR79024
FM212238
CAR79025
FM212239
CAR79026
FM212240
CAR79027
FM212241
CAR79028
Q5VWK5
NC_000072
NM_144548
NP_653131
AC124758
AC159129
CH466523
EDK98806
AF461423
AAM44230
BC112425
AAI12426
Q8K4B4
NC_005103
XM_001072576
XP_001072576
AC_000072
XM_003753910
XP_003753958
AABR07060866
AABR07060867
AABR07060868
AAHX01030717
AAHX01030718
XM_011540789
XP_011539091
NC_018912
AMYH02001199
AMYH02001200
BC166698
AAI66698
AC_000028
AAHY01053986
AAHY01053987
AAHY01053988
AAHY01053989
AAHY01053990
AC_000133
CAI22678
CAI22679
CAH70406
CAH70408
AABR06031415
AABR06031416
NT_032977
NW_001838579
NW_921351
AC_000044
NT_039353
NW_001030811
NW_047693
AABR03032103
AABR03032115
AABR03032433
AABR03032994
AABR03033128
AABR03033382
AABR03033708
AABR03033724
AABR03033734
AABR03033826
AABR03033883
AABR03034599
AABR03034647
AABR03034738
AABR03034919
AABR03035608
AABR03035767
AABR03036073
AABR03036074
AABR03036372
AABR03036455
AABR03036509
AABR03037599
AABR03037691
AABR03037915
AABR03039511
AABR03039880
AABR03039937
XM_005270512
XP_005270569
XM_005270517
XP_005270574
ABBA01074519
ABBA01074520
ABBA01074521
ABBA01074522

Swiss-Prot ID IL23R_HUMAN
IL23R_MOUSE

Cell Localization Cell membrane
Plasma membrane

Ensembl ID ENSG00000162594
ENSP00000321345.5
ENST00000347310.9
ENSP00000490340.1
ENST00000637002.1
ENSMUSG00000049093
ENSMUSP00000113342.1
ENSMUST00000118364.1
ENSRNOG00000007544
ENSRNOP00000010151.5
ENSRNOT00000010151.5
ENSP00000321345
ENST00000347310
ENSP00000387640
ENST00000425614
ENSMUSP00000113342
ENSMUST00000118364
ENSRNOP00000010151
ENSRNOT00000010151

MGI ID MGI:2181693
2181693

RGD ID 1586368

Unigene ID Mm.221227
Hs.677426
Rn.134349

Homologene ID 16930

Shape Stick-vertex

IPI ID IPI00303045
IPI00479853
IPI00815647
IPI00816048
IPI00816154
IPI00816175
IPI00816507
IPI00987402
IPI00170196
IPI00776919
IPI00192508