Protein IL12RB1

URN urn:agi-llid:3594
Total Entities 0
Connectivity 418
Name IL12RB1
Description interleukin 12 receptor subunit beta 1
Notes The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway CD8+ T-Cell Activation
Th1-Cell Differentiation
Th17-Cell Differentiation
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Follicular Lymphoma
Il17 Signaling Related Neutrophilia in Asthma
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
IL23A and IL17A Provoke Cancer-Associated Inflammation
IL12R -> STAT Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL12B Expression Targets
PPAR Psoriasis
1_Differentiation of psoriatic T cells
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
Differentiation of psoriatic T cells

MedScan ID 3594
171333

LocusLink ID 3594
16161
171333

Alias IL-12 receptor beta component
IL12RB
interleukin-12 receptor subunit beta-1
LOC270057
interleukin IL-12R-beta1
IL-12 receptor subunit beta-1
interleukin IL-12 receptor beta
interleukin IL-12 receptor beta component
IL-12R subunit beta-1
IL-12R[b]
Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)
interleukin IL12rb I
Interleukin-12 receptor beta
IL-12 receptor beta
I12R
interleukin 12 receptor beta 1 subunit
IL12rb I
MGC34454
IL12 receptor component
IL-12R(b)
interleukin IL-12R-beta I
interleukin IL12 receptor component
I12R_HUMAN
LOC234387
IL-12R-beta1
interleukin IL-12R(b)
CD212 antigen
IL12rb1
interleukin IL12rb1
interleukin IL12 receptor, beta 1
antigen CD212
interleukin IL-12R[b]
interleukin 12 receptor, beta 1
CD212
interleukin IL12RB
cluster of differentiation 212
IL-12R-beta I
IMD30
interleukin-12 receptor beta-1 chain
IL-12R-beta-1
IL-12RB1

GO ID 0019955
0004896
0016517
0005143
0042019
0042020
0071346
0019221
0035722
0038155
0001916
0002827
2000330
2000318
0042104
0002230
0032729
0043382
0007165
0009897
0042022
0072536
0005886
0043235
0018108
0016021
0016020
0004872

KEGG ID hsa:3594
mmu:16161
rno:171333

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 8 34.21 cM
8 33.5 cM

OMIM ID 601604
614891
209950

Rat chromosome position 16p14

Hugo ID 5971
HGNC:5971

Human chromosome position 19p13.11
19p13.1

Swiss-Prot Accession P42701
P42701.1
Q60837
A0A1D5RL98
Q60837.2
E9PSU7
A8K308
B2RPF1
B7ZKK3
Q8N6Q7
Q3UV59
Q3TAD0
Q6PG56

PIR ID I37892
I49295

GenBank ID NC_000019
XM_011527966
XP_011526268
XM_011527967
XP_011526269
XM_011527968
XP_011526270
XM_011527969
XP_011526271
XM_011527974
XP_011526276
XM_011527973
XP_011526275
XM_017026762
XP_016882251
XM_011527970
XP_011526272
XM_011527972
XP_011526274
XM_011527971
XP_011526273
XM_006722741
XP_006722804
XM_011527975
XP_011526277
NM_001290024
NP_001276953
NM_001290023
NP_001276952
NM_005535
NP_005526
XM_011527976
XP_011526278
XM_011527977
XP_011526279
NM_153701
NP_714912
NG_007366
AC020904
AJ297688
CAC10446
AJ297689
AJ297690
AJ297691
AJ297692
AJ297693
AJ297694
AJ297695
AJ297696
AJ297697
AJ297698
AJ297699
AJ297700
AJ297701
AY771996
AAV28734
CH471106
EAW84653
EAW84654
EAW84655
EAW84656
AI637915
AK225919
AK290423
BAF83112
BC029121
AAH29121
BC137404
AAI37405
BC137406
AAI37407
BX647221
DA008204
U03187
AAA21340
P42701
NC_000074
XM_006509559
XP_006509622
XM_006509557
XP_006509620
XM_006509560
XP_006509623
NM_008353
NP_032379
XM_006509558
XP_006509621
XM_006509561
XP_006509624
XM_011242266
XP_011240568
XM_006509562
XP_006509625
AC162446
AY170846
CH466569
EDL28875
EDL28876
AK137577
BAE23414
AK171937
BAE42738
U23922
AAA87457
Q60837
NC_005115
XM_006252821
XP_006252883
NM_001170604
NP_001164075
AC_000084
AABR07024875
AAHX01086843
CH474031
EDL90740
AF083328
AAD16039
NC_018930
AMYH02035720
AMYH02035721
AMYH02035722
AMYH02035723
EU832463
ACE87635
EU832511
ACE87683
EU832545
ACE86947
EU832592
ACE86994
JF432889
ADZ16106
AC_000030
AAHY01071879
BC057212
AAH57212
XM_005259893
XP_005259950
AC_000151
ABBA01051245
ABBA01051246
NT_011295
NW_927195
NW_001838484
AC_000062
NT_039462
NW_001030897
Q3TAD0
Q3UV59
Q6PG56

Swiss-Prot ID I12R1_HUMAN
I12R1_MOUSE
Q3UV59_MOUSE

Cell Localization Membrane
Plasma membrane

Ensembl ID ENSG00000096996
ENSP00000472165.2
ENST00000593993.6
ENSP00000314425.5
ENST00000322153.11
ENSMUSG00000000791
ENSMUSP00000000808.7
ENSMUST00000000808.7
ENSMUSP00000148279.1
ENSMUST00000212657.1
ENSRNOG00000019216
ENSRNOP00000025977.6
ENSRNOT00000025977.6
ENSP00000472165
ENST00000593993
ENSP00000314425
ENST00000322153
ENSMUSP00000000808
ENSMUST00000000808
ENSRNOP00000025977
ENSRNOT00000025977

MGI ID MGI:104579
104579

RGD ID 620025

Unigene ID Hs.567294
Mm.731
Rn.162266
Rn.233637

Homologene ID 4042

Shape Stick-vertex

IPI ID IPI00121384
IPI00001400
IPI00218703
IPI00297449
IPI00877269
IPI00795120
IPI00461866