Protein GNAI2

URN urn:agi-llid:2771
Total Entities 0
Connectivity 958
Name GNAI2
Description guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Notes The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Primary Cell Localization Cytoplasm

Pathway Serotonin Receptors Signaling
CXC Chemokine Receptor Signaling
Proplatelet Maturation
Eicosanoids in Myeloid Cell Activation
Eosinophil Activation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Neutrophil Recruitment and Priming
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Potassium Flux Regulation
Nociception Expression Targets Signaling
Vascular Motility
Ca2+ Flux Regulation
NPY1R -> CRH/POMC Production
CRH -> Synthesis of Corticosteroids
ADORA3 -> Mast-Cell Degranulation
BDKRB1/2 -> Vasodilation
BDKRB1/2 -> Ion Channels
BDKRB1/2 -> Prostaglandin Generation
BDKRB1/2 -> Interleukins Production
CNR1/2 -> Membrane Transport
CNR1/2 -> Vascular Motility
CNR1/2 -> IL1B/2/4/6/10 Production
GALR1/2/3 -> POMC/NPY Production
GALR1/2/3 -> Neurotransmitter Metabolism
CHRM1 -> IL2 Production
CHRM1/2/3/5 -> Ion Channels
CHRM1/2/3 -> Vascular Motility
OPRD/OPRM -> Ion Channels
HTR1 -> IL6 Production
HTR1 -> Membrane Transport
HTR1 -> Vascular Motility
GRM2-4/6-8 (Presynaptic) -> Glutamate Release Attenuation
P2RY2/12/13/14 -> N-Type Calcium Channel
Proteins Involved in Arterial Hypertension
Contraction Due Vasospasm
Melanoma
Oxidative Stress in Vitiligo
Vitiligo
Eosinophil Activation and Degranulation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
Vascular Smooth Muscle Cell Vasodilation in Brain
NO Effect on Vasodilation and Vasoconstriction
MIF Role in Cholesteatoma
Cholesteatoma
Acetylcholine Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
FPR1 -> Cytoskeleton Signaling
EGFR Transactivation in Cancer and Non-Cancer Cells
Dronabinol/Anandamide Expression Targets
NPY Expression Targets
Ras-GRF Regulation Signaling
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
Model of PPARG signaling in psoriais (tested)

MedScan ID 2771

LocusLink ID 2771
14678
81664

Alias H_LUCA15.1
Guanine nucleotide-binding protein G(i), alpha-2 subunit
guanine nucleotide binding protein (G protein), alpha inhibiting 2
GBI2_HUMAN
WUGSC:H_LUCA16.1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
WUGSC:H_LUCA15.1
GTP-binding regulatory Gi alpha-2 chain
LOC102642216
GTP-binding protein (G-alpha-i2)
OTTHUMP00000211067
guanine nucleotide-binding protein G(i) subunit alpha-2
guanine nucleotide binding protein, alpha inhibiting II
OTTHUMP00000211070
G alpha inhibitory type 2 (a)
G(i), alpha II
OTTHUMP00000211066
G protein alpha inhibiting activity polypeptide 2
H_LUCA16.1
C76432
g alpha inhibitory type 2
G(i2)
G alpha i2
Gnai2
G protein alpha inhibiting activity polypeptide II
GBI2
GTP-binding regulatory protein Gi alpha-2 chain (adenylate
Galphai2
Gia
guanine nucleotide binding protein, alpha inhibiting 2
G(i), alpha-2
Adenylate cyclase-inhibiting G alpha protein 2
G protein subunit alpha i2
G alpha inhibitory type 2 (b)
Adenylate cyclase-inhibiting G alpha protein II
GNAI2B
Guanine nucleotide-binding protein (G protein), alpha-inhibiting
GIP
GTP-binding regulatory protein Gi alpha-2 chain
adenylate cyclase-inhibiting G alpha protein
Gnai-2

GO ID 0001664
0031683
0005525
0003924
0046872
0007213
0007186
0001973
0007189
0007193
0007188
0007049
0051301
0008283
0007214
0007194
0140199
2001234
0045955
1903614
0050805
0070374
0033864
0030335
0008284
0046628
2000179
0035815
0032930
0035810
1904707
0006457
0051924
0007584
0007165
0044297
0005813
0005737
0005829
0030425
0070062
1903561
0005834
0016020
0045121
0030496
0005654
0005886
0019001
0000166
0008016
0005856
0005634
0007216
0070382
0004871
0000186
0035556
0008152
0007596
0030168
0007268
0031982
0031234
0006184
0007243
0051927
0005624

KEGG ID hsa:2771
mmu:14678
rno:81664

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 9 58.43 cM
9 59.0 cM

OMIM ID 139360
192605

Rat chromosome position 8q32

Hugo ID 4385
HGNC:4385

Human chromosome position 3p21.31
3p21

Swiss-Prot Accession B3KP24
B3KX51
P04899
P04899.3
P08752
P08752.5
P04897
Q45QN0
P04897.3
B3KTZ0
B4DYA0
B4E2X5
Q6B6N3
Q8IZ71
Q3TXK7
Q6P1C0
Q6LCB5
Q93020
Q96C71
Q8JZT4
Q922Y6
Q5EEY3
Q5EEY4

PIR ID S02319
B25889
D27423

GenBank ID NC_000003
NM_001282619
NP_001269548
NM_001282620
NP_001269549
NM_001282617
NP_001269546
NM_002070
NP_002061
NM_001282618
NP_001269547
NM_001166425
NP_001159897
NG_016002
AC002077
AH001470
AAA35894
CH471055
EAW65051
EAW65052
EAW65053
EAW65054
EAW65055
EAW65056
KT584007
U73166
AAD12230
U73169
AAD12229
X07854
CAA30703
AF493906
AAM12620
AK055574
BAG51536
AK096299
BAG53252
AK096595
BAG53334
AK126708
BAG54363
AK131062
AK302330
BAG63662
AK304473
BAG65287
AY677118
AAT78421
BC012138
AAH12138
BC014627
AAH14627
BC016995
AAH16995
CR456783
CAG33064
DA528337
DB044421
HY037331
J03004
AAA52556
X04828
CAA28512
P04899
NC_000075
XM_006511637
XP_006511700
NM_008138
NP_032164
AC162905
AL672219
AK157998
BAE34308
AK159222
BAE34909
AK160186
AK167388
BAE39478
AK177418
AK178281
AK178376
AK178445
AK179275
AK179602
AK179809
AK183811
AK183887
AK184440
AK185434
AK185758
AK188055
AK191152
AK192434
AK192815
AK197984
AK202003
AK206522
AK206873
AK207227
AK210682
AK212898
AK215781
AK216428
AK219691
BC006695
AAH06695
BC037130
AAH37130
BC065159
AAH65159
CF951009
CJ134826
M13963
AAA37692
S71213
AAB30632
S79607
P08752
NC_005107
XM_006243858
XP_006243920
NM_031035
NP_112297
AC_000076
AAHX01056979
AC106346
CH473954
EDL77222
AY899210
AAX07753
AY899211
AAX07754
BC078806
AAH78806
CO394955
CR465951
DQ120471
AAZ23810
DQ120472
AAZ23811
M12672
AAA41260
M17528
AAA40824
P04897
NC_018914
AMYH02006766
M20586
M20587
M20588
M20589
M20590
M20591
M20592
M20593
DQ892783
ABM83709
DQ895908
ABM86834
AC_000031
AAHY01081493
AAHY01081494
AAHY01081495
AAHY01081496
AAHY01081945
AK185480
AC_000135
ABBA01024553
XM_005265066
XP_005265123
XM_005265068
XP_005265125
XM_005265067
XP_005265124
NW_003871059
XM_006243859
XP_006243921
AABR06057030
NT_022517
NW_001838877
NW_921651
AC_000046
CR593068
CR599468
CR603761
CR604433
CR606737
CR609921
CR610539
CR618994
Q6B6N3
Q6LCB5
Q93020
Q96C71
NT_039477
NW_001030918
Q3TXK7
Q8JZT4
Q922Y6
NW_047801
NW_001084876
Q45QN0
Q5EEY3
Q5EEY4
NW_001030920

Swiss-Prot ID GNAI2_HUMAN
GNAI2_MOUSE
GNAI2_RAT
Q3TXK7_MOUSE
B3KX51_HUMAN
B4DYA0_HUMAN
Q45QN0_RAT
B3KP24_HUMAN

Cell Localization Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Cell membrane
Membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Ensembl ID ENSG00000114353
ENSP00000406369.1
ENST00000451956.1
ENSP00000266027.6
ENST00000266027.9
ENSP00000406871.1
ENST00000422163.5
ENSP00000312999.6
ENST00000313601.11
ENSMUSG00000032562
ENSMUSP00000057543.6
ENSMUST00000055704.11
ENSMUSP00000142326.1
ENSMUST00000192615.5
ENSRNOG00000016592
ENSRNOP00000022550.4
ENSRNOT00000022550.6
ENSP00000406369
ENST00000451956
ENSP00000266027
ENST00000266027
ENSP00000406871
ENST00000422163
ENSP00000312999
ENST00000313601
ENSMUSP00000057543
ENSMUST00000055704
ENSMUSP00000142326
ENSMUST00000192615
ENSRNOP00000022550
ENSRNOT00000022550

MGI ID MGI:95772
95772

RGD ID 620243

Unigene ID Hs.77269
Mm.196464
Rn.3036

Homologene ID 55539

IPI ID IPI00217906
IPI00748145
IPI00926935
IPI01015661
IPI00231925
IPI00228617
IPI00652902
IPI00924427
IPI00794986
IPI00465121
IPI00796250
IPI00798195
IPI00797567
IPI00925691