Small Molecule inositol (1,4,5)P3

URN urn:agi-cas:85166-31-0
Total Entities 0
Connectivity 1474
Name inositol (1,4,5)P3
Description inositol 1,4,5 -trisphospate
Class Endogenous compound
Molecular Weight 420.095583
XLogP -7.300000

Pathway Skin Aging
GCG and PPY Regulate Metabolism and Satiety
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Taste Receptors Activation in Tongue
L-cell: GCG, PYY and 5-HT Release
P-cell Activation
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
D-cell: Somatostatin Release
A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
G-cell: Gastrin Secretion
ECL-cell: CHGA and Histamine Synthesis
Insulin Secretion
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Catecholamines Secretion from Adrenal Gland
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Norepinephrine Release Regulation
Dopamine Synthesis and Release
CRH Secretion Regulation
Prolactin Production
Oxytocin Action in Mammary Gland
Thrombopoietin Receptors Signaling in Platelet Maturation
Mineralcorticoids Secretion Regulation
Dectin-1 (CLEC7A) Signaling
Dectin-2 (CLEC6A)/Mincle (CLEC4E)/BDCA2 (CLEC4C) Signaling
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
V(D)J Recombination Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
Peripheral T-Cell Tolerance
T-Cell Central Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Platelet Activation via Adhesion Molecules
Scavenger Receptors in Platelet Activation
Scavenger Receptors in Platelet Aggregation
Proplatelet Maturation
Bradykinin Effects in Inflammation
Platelet Activation via GPCR Signaling
Lipoxin A4/FPR2-Related Neutrophil Depression
Annexins in Inflammation Resolution
Eat me Signal: Apoptotic Cell Induces Phagocytosis
Leukotriene Effect on Vascular Endothelial Cell Response
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Histamine Receptor H3 Signaling in Neurons
Prostaglandin E2 and Histamine in Gastric Acid Secretion
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
SNS Related Adrenal Cortex Response
Vascular Endothelial Cell Activation by NO
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Potassium Flux Regulation
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
Vascular Motility
Ca2+ Flux Regulation
TAAR1 -> Neurotransmitter Uptake
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
CRH -> Synthesis of Corticosteroids
EDNRA/B -> Vascular Motility
CCKBR -> Neurotransmitter Uptake
ADORA3 -> Mast-Cell Degranulation
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA1 -> Ion Channels
ADRA2C/ADRB2 -> Vasoconstriction
ADRA2C/ADRB2 -> Synaptic Endocytosis
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Ion Channels
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> Membrane Transport
CNR1/2 -> Vascular Motility
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
GALR1/2/3 -> POMC/NPY Production
GALR1/2/3 -> Neurotransmitter Metabolism
HRH1/2 -> Membrane Polarization
HRH1/3 -> Synaptic Transmission
HRH1/2 -> Vascular Motility
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3/5 -> Ion Channels
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGFR -> Vasoconstriction
PTGIR -> IL6 Production
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR2 -> Membrane Transport
HTR1 -> Membrane Transport
HTR1 -> Vascular Motility
TACR1 -> Membrane Transport
TACR1 -> TNF/IL6/IL8 Production
GRM1/5 (Postsynaptic) -> Ion Channels
P2RY11/13/14 -> IL8/10 Production
P2RY1/2/4/6 -> Potassium Channels
NTRK1/2/3 -> Acetylcholine Production
EPHB -> NMDA Receptor Activation
Luteinizing Hormone in Oocyte Meiotic Resumption
Agomelatine Antidepressant Action
Histamine in Arousal Regulation
Circadian Clock in Sleep Regulation
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Hypocretin (Orexin) in Arousal Regulation
Adenosine Role in Sleep Regulation
Retinal Ganglion and Suprachiasmatic Nucleus in Melatonin Synthesis Regulation
RHO Signaling (Light Signal Termination and Photoreceptor Recovery)
Vitamine D Deficite and Dentin Formation
G0/G1 Phase Transition
Gap Junction Assembly
Th1-Cells Activation and Proliferation in Atherosclerosis
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Endothelial Cell Dysfunction in Arterial Hypertension
Aldosterone Synthesis Chronic Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Vascular Reactivity in Raynaud Disease
Cold Stress and Adrenoceptor alpha 2C Signaling in Raynaud Disease
NO Synthesis in Early Vasospasm
Neurons Necrosis Caused by Energy Deficiency
Contraction Due Vasospasm
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Cell Cycle Dysregulation in Melanoma
WNT Signaling in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Oxidative Stress in Vitiligo
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Proliferative Diabetic Retinopathy
G-Proteins Signaling in Insulin Secretion in beta-Cell
Olanzapine Effect on Insulin Secretion in Diabetes Mellitus
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
Immune System Activation in Hyperthyroidism
GNRH Release Impairment in Hypogonadotrophic Hypogonadism
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
KISS1 Production Impairment in Hypogonadotropic hypogonadism
Hypothyroidism, Secondary (Central)
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Central Hypothyroidism
Tertiary Hypothyroidism
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Metastatic Colorectal Cancer
B-Cell Activation in Crohn's Disease
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Antiphospholipid Antibodies in Platelets and Coagulation Cascade
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Splenic Marginal Zone Lymphoma
Multiple Myeloma
Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
T-Cell Acute Lymphoblastic Leukemia
TRPM7/8 in Pancreatic Adenocarcinoma
Eosinophil Survival in Asthma
Eosinophil Activation and Degranulation in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Airway Smooth Muscle Cell Contraction
Goblet-Cell Exocytosis in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
Antigen-Presenting Cell Role in Asthma
Th2-Cell Response in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Ovulation Block
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
PTPN22 Role in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
WHIM Syndrome
Dentin Formation Disruption
CCR5 Signaling in Macrophages
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
Acinar Cells in the Saliva Formation
Epithelial Cell in the Saliva Formation
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Ca2+ Toxicity in Neurons
BDNF Upregulation Triggered by Seizures
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Glutamate, D-Serine, and ATP Release from Astrocytes
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Vascular Endothelial Cell Vasodilation in Brain
CCL2 Role in CGRP Expression and Release
Dopamine Synthesis and Release in Migraine
Vascular Smooth Muscle Cell Vasodilation in Brain
Postsynaptic Neuron Activation
eNOS (NOS3) Activation via Prostaglandin E2 and Histamine
NO Effect on Vasodilation and Vasoconstriction
GABRB3 Mutation and Adenosine Deaminase Polymorphism
Hypocretin Elevation and Monoamine Oxidase Decrease/Inhibition
Brain Cell Necrosis in Vascular Dementia
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
EGFR and PTAFR Signaling in Ovarian Cancer
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
TRPM8 Effects in Prostate Cancer (Hypothesis)
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
Ca2+ Toxicity in Lens Cells
VEGFA in Neovascular Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
PGF2-alpha Effect on Treatment
Serotonin Signaling in the Ciliary Body
Cytokines Trigger Otitis Media
Alveolar Macrophages Dysfunction in COPD
Muscarinic Receptor-Mediated Airway Smooth Muscle Contraction
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
Alveolar Epithelial Cell Dysfunction in COPD
Penile Detumescense Augmentation Mechanisms
Endothelial Cell Dysfunction in Glomerulonephritis
Sertoli Cells Dysfunction Causes Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
B-Cell Receptor -> NFATC Signaling
B-Cell Receptor -> AP-1 Signaling
B-Cell Receptor -> NF-kB Signaling
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
SELE -> ELK-SRF Signaling
CD2 Expression Targets
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD8 -> AP-1 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD72 -> NF-kB Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD8 -> NF-kB Expression Targets
CD80 -> AP-1 Expression Targets
CD81 Expression Targets
CD80 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD86 -> NFATC Expression Targets
CD86-> NFATC Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
Inositol Phosphate Metabolism
Complement Component GPCRs Signaling
Doxorubicin Induced Cardiotoxicity
Clozapine Induced Granulocytopenia
Cyclosporine Induced Nephrotoxicity
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FPR1 -> Cytoskeleton Signaling
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
EGFR Transactivation in Cancer and Non-Cancer Cells
TAM Receptor Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
NFKB Canonical Signaling Activation in Cancer
VEGF Independent Angiogenesis in Cancer
CDH2 Activation Promotes Cancer Cell Migration and Survival
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
CD2 -> NFATC1 Signaling
CD19 -> JUN/ELK Signaling
FcIgER -> NFATC1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL16 -> AP-1 Expression Targets
IL16-> ATF/CREB/CREBBP Expression Target
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
PGE1 Expression Targets
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
NPY Expression Targets
AVP/Gq -> STAT Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
PDCD1 -> NFATC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
WNT/Calcium non-Canonical Signaling
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
MERTK Signaling
Ras Signaling
AXL Receptor Tyrosine Kinase Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
NF-kB Canonical Signaling
ERK/MAPK Canonical Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> NFAT Expression Targets
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
T-Cell Receptor -> NF-kB Signaling
T-Cell Receptor -> NFATC Signaling
T-Cell Receptor -> CREBBP Signaling
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
IL1B -> PGE2 Expression Targets
ROS in Neutrophil Mediated Cell Damage
ROS in Triggering Vascular Inflammation
ROS and RNS in Vasoconstriction and Vasodilation Regulation
Ca2+ Cytosolic Overload
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
ace2
cypa
Model of PPARG signaling in psoriasis
New Pathway
2_Acute phase initiation in atopic dermatitis
1_The onset of atopic dermatitis
2_Podocyte dysfunction in glomerulonephritis
3_Enhanced angiogenesis in endometriosis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
4_Endothelial cells repress vasoconstriction in hypertension
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_1_Mucus accumulation in asthma
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_1_Airway smooth muscle cells contraction
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
1_2_Insulin synthesis and secretion: insulin secretion
1_1_Insulin synthesis and secretion: insulin processing and storage
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
3_Islet beta-cell destruction in T1D
3_Pain perception in diabetic neuropathy
2_Neuron and Schwann cell death
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
1_2_Glutamate overload and NO-mediated vasodilation
1_Decreased secretion of thyroid hormones
2_1_General pathways of thyroid hormone signaling

Source ChemIDplus
curated
KEGG
Biopax
AraCyc

MedScan ID 1215308
1052585

Alias inositol triphosphate
[3H]inositol 1,4,5-trisphosphate
D-myo-Inositol, 1,4,5-tris(dihydrogen phosphate)
[3H] inositol 1,4,5-triphosphate
inositol 1,4,5-trisphosphates
D-myo-inositol 1,4,5-trisphosphate
85166-31-0
[3H] inositol trisphosphate
Ins(1,4,5)P3
inositol tris(phosphate)
InsP1,4,5
inositol tri-phosphate
inositol 1,4,5-tri-phosphate
myoinositol 1,4,5-Triphosphate
myo-Inositol 1,4,5-trisphosphate
1,4,5-Insp3
[3H]inositol-1,4,5-P3
inositol phosphate 3
inositol trisphosphates
myo-inositol 1,4,5-triphosphate
inositol trisphosphate
inositolphosphate 3
Ins(1,4,5)triphosphate
[2-3H] inositol trisphosphate
(2,3,5-trihydroxy-4,6-diphosphonooxy-cyclohexoxy)phosphonate
1,4,5-inositol trisphosphate
InsP3
[3H]inositol triphosphate
D-inositol 1,4,5-trisphosphate
1D-myo-inositol 1,4,5-trisphosphate
D-InsP3
inositol 1,4,5-trisphosphate-3H
[14C]inositol 1,4,5-trisphosphate
88269-39-0
inositol (1,4,5)P3
(2,3,5-trihydroxy-4,6-diphosphonooxy-cyclohexoxy)phosphonic acid
Inositol (1,4,5)triphosphate
myo-Inositol, 1,4,5-tris(dihydrogen phosphate)
Inositol 1,4,5-trisphosphate
inositol 1,4,5-trisphospate
1,4,5-IP3
Inositol 1,4,5-trisphosphic acid
inositol 1,4,5-trisphosphate-14C
InsP1
InsP
inositol phosphates
inositol phosphate-14C
inositol phosphate-3H
[14C]inositol phosphate
[3H]inositol phosphate
[(3)H]inositol phosphates
[2-3H] inositol phosphates
inositol phosphate
inositol 1,4,5 -trisphospate
molecular compounds D-myo-inositol 1,4,5-trisphosphate
Inositol 1,4,5-triphosphate
I(1,4,5)P3
1D-myo-inositol (1,4,5)-trisphosphate
inositol (1,4,5)-trisphosphate

CAS ID 85166-31-0
88269-39-0

Reaxys ID 2634683
2634684
3598587
3658344
3658345
3658347
4726478
4726479
4770582
5386072
5386073
6078045
4303027
14628102
4303028
6995755
4651116
8590038

ChEBI ID 16595

HMDB ID HMDB01498

KEGG ID C01245

InChIKey MMWCIQZXVOZEGG-HOZKJCLWSA-N

Molecular Formula C6H15O15P3

Cell Localization Cytoplasm
Nucleus

PubChem SID 135013591
135115234
192780
736678
8143490

PubChem CID 55310
439456

XLogP-AA -7

IUPAC Name [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxy-cyclohexyl] dihydrogen phosphate

Rotatable Bond Count 6

ChemIDplus ID 088269390
085166310

BioCyc ID inositol_1,4,5-trisphosphate

Patent ID US5260472
EP359256
US4755612
US2003/166103
US4873355
US5057507
US5756774
US5128332
US6139902
US5284839
US5330979
US5846957
US5866557

KEGG Entry C01245

DB Link CAS: 88269-39-0
PubChem: 4466
ChEBI: 16595