Protein CSF3

URN urn:agi-llid:1440
Total Entities 0
Connectivity 4635
Name CSF3
Description colony stimulating factor 3 (granulocyte)
Notes The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Primary Cell Localization Extracellular
Class Ligand

Pathway Neutrophil Recruitment and Priming
IL1B Expression Targets -> Nociception
Myeloid Progenitor Cell -> GEMM - CFU Surface Expression Markers
Proteins Involved in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Proteins Involved in Acne Vulgaris
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
Neutrophil Recruitment in Sinovium in Gout
Proteins Involved in Osteoporosis
Proteins Involved in Noise-Induced Hearing Loss
Cytokines Trigger Otitis Media
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Pyelonephritis
Elevated Receptors -> Expression Targets in Bone and Joint
CSF3 Expression Targets
Clozapine Induced Granulocytopenia
F2 -> STAT1/NF-kB Expression Targets
Elevated Receptors -> Expression Targets in Appendix
Myeloid Derived Suppressor Cells in Cancer Immune Escape
Proteins with Altered Expression in Cancer Immune Escape
NOTCH -> Expression Targets in Skin
CD40 -> Expression Targets in Lymph Node
NOTCH -> Expression Targets in Thymus
Adenosine Expression Targets
ERK5/MAPK7 Signaling
TNF -> NF-kB Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of leukocyte count
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of recurrence rate
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of bone volume
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of leukocyte count
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of recurrence rate
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of bone volume
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of neoplasm invasion
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of kidney tubule cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of hematopoietic cell
Neighbors of pericyte
Neighbors of phagocyte
Neighbors of lymphocyte
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of heart
Neighbors of esophagus
Neighbors of brain
Neighbors of breast
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of pancreas
Neighbors of lymphatic system
Neighbors of decidua
Neighbors of peritoneum
Neighbors of allantois
Neighbors of uterine cervix
Neighbors of arteriole
Neighbors of nose
Neighbors of mammary gland
Neighbors of bladder
Neighbors of nervous system
Neighbors of mediastinal lymph node group
Neighbors of NF-kB family
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of MEK1/2
Neighbors of growth factor
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of protein tyrosine kinase
Neighbors of LXR
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of immunoglobulin
Neighbors of CD3 complex
Neighbors of TORC1
Neighbors of histone acetyltransferase
New Pathway (4)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 1440

LocusLink ID 1440
12985
25610

Alias granulocyte growth factor
colony stimulation factor 3 isoform b
CSF3OS
colony stimulation factor III
MGC45931
granulocyte colony-simulation factor
granulocyte growth factors
colony stimulating factor 3 isoform c
MGI-IG
G-CSF receptor ligand
Granulocyte colony-stimulating factor
colony stimulating factor 3 isoform a
G-CSF
colony stimulating factor,granulocyte
Csfg
colony stimulating factor III
OTTHUMP00000164327
CSF3_MOUSE
GCSF
colony stimulating factor 3 isoform b
chromosome 17 open reading frame 33
OTTMUSP00000006785
RP23-395E10.4
Pluripoietin
colony stimulating factor 3
colony stimulation factor 3 isoform a
Granulocyte colony-stimulation factor
colony stimulation factor 3 isoform c
CSF3
colony stimulation factor 3 (granulocyte)
C17orf33
granulocyte colony-stimulating factor receptor ligand
granulocyte colony-simulating factor
colony stimulation factor 3
colony stimulating factor 3 (granulocyte)
filgrastim
granulocyte-colony stimulating factor
lenograstim

GO ID 0005125
0019899
0005130
0008083
0071345
0071222
0019221
0030851
0006955
0007275
1901215
0051091
2000251
0030838
0008284
0045639
0033138
0050731
0014068
0032092
0051897
0045944
0045471
0005576
0005615
0010469
0042993

KEGG ID hsa:1440
mmu:12985
rno:25610

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 11 62.45 cM

OMIM ID 138970

Rat chromosome position 10q31

Hugo ID 2438
HGNC:2438

Human chromosome position 17q21.1
17q11.2-q12

Swiss-Prot Accession P09919
Q8N4W3
Q6FH65
P09919.1
P09920
Q0VB73
P09920.1
A8MXR7
P97712

PIR ID A24573
A25093
A29536

GenBank ID NC_000017
NR_033662
NM_000759
NP_000750
NM_172220
NP_757374
NM_172219
NP_757373
NM_001178147
NP_001171618
AC090844
AF388025
AAK62469
CH471152
EAW60626
EAW60627
EAW60628
EU660495
ACF41164
FB704344
CAS03439
FJ854694
ACP21316
M13008
AAA03056
X03656
CAA27291
AB102881
BAD89410
AK290247
BAF82936
AK298116
BAG60399
AK313509
BAG36289
BC033245
AAH33245
CB127794
CD013926
CR541891
CAG46689
HM132049
ADI49832
KP271008
AJC19277
M17706
AAA35882
M20922
AAA66353
X03438
CAA27168
X03655
CAA27290
P09919
NC_000077
XM_006532128
XP_006532191
NM_009971
NP_034101
AL590963
CH466556
EDL16160
X05402
CAA28986
AK145177
BAE26276
BC120759
AAI20760
BC120761
AAI20762
M13926
AAA37672
P09920
NC_005109
NM_017104
NP_058800
AC_000078
AAHX01065923
AC119462
CH473948
EDM05943
U37101
AAC52915
NC_018928
AMYH02033391
AC_000033
AAHY01095698
XM_006247265
XP_006247327
AC_000149
ABBA01031851
AABR06065504

Swiss-Prot ID CSF3_HUMAN
CSF3_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000108342
ENSP00000225474.2
ENST00000225474.6
ENSP00000464421.1
ENST00000583218.5
ENSP00000377705.3
ENST00000394149.7
ENSP00000377704.3
ENST00000394148.7
ENST00000331769.6
ENSMUSG00000038067
ENSMUSP00000037762.2
ENSMUST00000038886.2
ENSRNOG00000008525
ENSRNOP00000011509.3
ENSRNOT00000011509.3
ENSP00000225474
ENST00000225474
ENSP00000464421
ENST00000583218
ENSP00000377705
ENST00000394149
ENSP00000377704
ENST00000394148
ENST00000331769
ENSMUSP00000037762
ENSMUST00000038886
ENSRNOP00000011509
ENSRNOT00000011509

MGI ID MGI:1339751
1339751

RGD ID 2426

Unigene ID Hs.2233
Mm.1238
Rn.53973

Homologene ID 7677

Shape Rhomb