Pathway
|
Proteins Involved in Stem Cell Exhaustion in Aging
|
|
Osteoarthritis
|
|
Androgen Deficiency in Male Obesity
|
|
Oncogene Induced Cellular Senescence
|
|
MTHFR Activity Regulation
|
|
DNA Persistent Repair Inhibits mTOR Signaling
|
|
mTOR Signaling Activation by Fatty Acids and Glucose
|
|
mTOR Signaling Activation by Amino Acids
|
|
mTOR Signaling
|
|
mTOR Signaling Hyperfunction
|
|
Telomer Attrition Triggers Genomic Instability
|
|
Insulin Influence on Protein Synthesis
|
|
Insulin Influence on Glycogenesis
|
|
Insulin Influence on Lipogenesis
|
|
Dopamine Receptors Signaling
|
|
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
|
|
Insulin Signaling
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
Androgens in Adipocyte Activation
|
|
LH and FSH Signaling and Steroidogenesis
|
|
Toll-like Receptors Act through MYD88-TIRAP Signaling
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Independent B-Cell Activation
|
|
Natural Killer Cell Activation through C-Type Lectin-like Receptors
|
|
T-Cell Maturation (Hypothesis)
|
|
Peripheral T-Cell Tolerance
|
|
T-Cell Positive Selection and Neglect Induced Death
|
|
T-Cell Central Tolerance
|
|
CD8+ T-Cell Activation
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
|
|
Th17-Cell Differentiation
|
|
AHR Signaling in Tr1 Cells Function
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Plasmin Effects in Inflammation
|
|
TAM Receptors in Platelet Aggregation
|
|
Platelet Activation via Adhesion Molecules
|
|
Proplatelet Maturation
|
|
Bradykinin Effects in Inflammation
|
|
Platelet Activation via GPCR Signaling
|
|
Toll-like Receptors in Sterile Inflammation
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
Eicosanoids in Myeloid Cell Activation
|
|
Histamine Receptor H3 Signaling in Neurons
|
|
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Eosinophil Activation
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cell Activation without Degranulation
|
|
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
VEGFA/NOTCH1/WNT Cross-talk in Blood Vessel Sprouting and Branching in Cancer
|
|
Vascular Endothelial Cell Activation by NO
|
|
Vascular Endothelial Cell Activation by Cytokines
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Vascular Endothelial Cell Permeability Activation
|
|
Adipokines Production by Adipocyte
|
|
Lipolysis Regulation in Adipocyte
|
|
Lipogenesis Regulation in Adipocyte
|
|
Synaptic Potentiation by PKMZ in LTP Maintenance - Active State
|
|
Nociception Expression Targets Signaling
|
|
Sodium Flux Regulation
|
|
Vascular Motility
|
|
BDKRB1/2 -> Vasodilation
|
|
BDKRB1/2 -> Interleukins Production
|
|
DRD2 -> TRPC1 Transcription
|
|
GALR1/2/3 -> POMC/NPY Production
|
|
PTGER2/3 -> Vascular Motility
|
|
TACR1 -> TNF/IL6/IL8 Production
|
|
Leptin -> NO Production/Vasodilation
|
|
Kidney Cells Cilia Organization
|
|
Apoptosis
|
|
G1/S Phase Transition
|
|
Cell Cycle Overiew
|
|
G0/G1 Phase Transition
|
|
G2/M Phase Transition
|
|
Tight Junction Assembly (Occludin)
|
|
Adherens Junction Assembly (Cadherins)
|
|
Actin Cytoskeleton
|
|
Telomere Maintenance
|
|
Axonal Transport
|
|
RAGE/AGER and S100 Proteins in Cardiovascular Injury
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Proteins Involved in Dilated Cardiomyopathy
|
|
Proteins Involved in Hypertrophic Cardiomyopathy
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Proteins Involved in Arterial Hypertension
|
|
Endothelin Signaling in Arterial Hypertension
|
|
Arterial Hypertension
|
|
Endothelial Cell Dysfunction in Arterial Hypertension
|
|
Smooth Muscle Cell Dysfunction in Arterial Hypertension
|
|
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
|
|
BMP2 and WNT Signaling in Pulmonary Artery Smooth Muscle Cells
|
|
Myocardial Remodeling
|
|
Myocardial Infarction
|
|
Proteins Involved in Myocardial Ischemia
|
|
Preconditioning Ischemia
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
Myocarditis, Acute Viral Overiew
|
|
Vascular Reactivity in Raynaud Disease
|
|
NO Synthesis in Early Vasospasm
|
|
Proteins Involved in Acne Vulgaris
|
|
Hyperseborrhea in Acne Vulgaris
|
|
Androgen Induced Sebocyte Hyperfunction
|
|
Androgens in Sebocyte Maturation
|
|
Atopic Dermatitis Onset
|
|
Proteins Involved in Ichthyosis
|
|
Melanoma
|
|
Apoptosis Block in Melanoma Cell
|
|
Dedifferentiation and Metastatic Progression in Melanoma
|
|
Proteins Involved in Melanoma
|
|
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
|
|
IL22 Induces Keratinocyte Proliferation in Psoriasis
|
|
Proteins with Altered Expression in Psoriasis
|
|
Dendritic Cells Function in Psoriasis
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
Toll-like Receptors in beta-Cell
|
|
Macrophage Function in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Proteins Involved in Diabetes Mellitus Type 2
|
|
Donohue Syndrome Progression (Hypothesis)
|
|
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
|
|
Protein Kinase C in Diabetic Microangiopathy
|
|
Peripheral Tissue Microangiopathy
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Podocyte Dysfunction in Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
|
|
Proteins Involved in Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
Microangiopathy in Diabetic Neuropathy
|
|
Proliferative Diabetic Retinopathy
|
|
Glucocorticoids in Insulin Resistance in Skeletal Muscles
|
|
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
|
|
AGE Related Insulin Resistance in Skeletal Muscles
|
|
Adiponectin in Insulin Resistance Prevention
|
|
Proteins Involved in Insulin Resistance
|
|
Insulin Resistance in Myocytes Induced by Obesity
|
|
Adiponectin Synthesis Declines in Insulin Resistance
|
|
Insulin Resistance in Hepatocytes
|
|
Proteins Involved in non-Alcoholic Fatty Liver Disease
|
|
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
|
|
PNPLA3 in non-Alcoholic Fatty Liver Disease
|
|
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
|
|
Leptin in Insulin Synthesis and Secretion
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Mass Regulation
|
|
beta-Cell Function Inhibition by Ciclosporine and Tacrolimus (Rodent Model)
|
|
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
|
|
RET1 Mutation in Hyperparathyroidism
|
|
Bone Remodeling in Hyperthyroidism
|
|
Cardiovascular Effects in Hyperthyroidism
|
|
Thyroid Dysfunction
|
|
Graves Ophthalmopathy
|
|
Immune System Activation in Hyperthyroidism
|
|
Myocyte Dysfunction in Hypoparathyroidism
|
|
GLIS3 Targets in Thyroid Dysgenesis (Hypothesis)
|
|
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
|
|
Overt Hypothyroidism, Primary
|
|
Thymic Follicular Hyperplasia
|
|
Adipocyte Hypertrophy and Hyperplasia
|
|
Adipokines Production by Adipocyte Impaired in Obesity
|
|
Proteins Involved in Obesity
|
|
CD4+T-Cell Response in Celiac Disease
|
|
Enterocyte Mediated Mucosal Damage in Celiac Disease
|
|
Proteins Involved in Colorectal Neoplasms
|
|
Cetuximab Resistance in Colorectal Cancer
|
|
Metastatic Colorectal Cancer
|
|
GUCY2C Signaling in Colorectal Cancer
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
Peutz-Jeghers Syndrome
|
|
Dendritic Cell Function in Ulcerative Colitis
|
|
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
|
|
Proteins Involved in Ulcerative Colitis
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
FLT3/KIT/MLL Signaling in Leukemia
|
|
Proteins Involved in Acute Myeloid Leukemia
|
|
Apoptosis Block in Acute Myeloid Leukemia Cell
|
|
RARA Signaling in Acute Myeloid Leukemia (M3)
|
|
Acute Myeloid Leukemia
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Proteins Involved in Chronic Myeloid Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Diffuse Large-B-Cell Lymphoma ABC Subtype
|
|
Proteins Involved in Diffuse Large-B-Cell Lymphoma
|
|
Lymphoma, GCB Subtype
|
|
Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
Proteins Involved in Mantle Cell Lymphoma
|
|
Mantle Cell Lymphoma
|
|
Cell Cycle Dysregulation in Mantle Cell Lymphoma
|
|
Apoptosis of Mantle Cell Deregulation
|
|
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
|
|
Hedgehog Signaling in Mantle Cell Lymphoma
|
|
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
|
|
Osteoclast Activation in Multiple Myeloma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
Proteins Involved in Multiple Myeloma
|
|
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Proteins Involved in Hepatocellular Carcinoma
|
|
Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Proteins Involved in Pancreatic Cancer
|
|
Pancreatic Ductal Carcinoma
|
|
Growth Factor Signaling in Pancreatic Neoplasms
|
|
Pancreatic Neuroendocrine Tumors
|
|
STK11 Signaling in Pancreatic Neoplasms
|
|
Il17 Signaling Related Neutrophilia in Asthma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Basophil Activation in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Mast-Cell Related Chemokines Signaling in Asthma
|
|
B-Cell Mediated IgE Production in Asthma
|
|
Th17-Cell Differentiation in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Osteoclast Activation in Gout
|
|
Proteins Involved in Osteoarthritis
|
|
Proteins Involved in Polycystic Ovary Syndrome
|
|
Ovulation Block
|
|
SHBG and IGFBP1 Synthesis Decline in Polycystic Ovary Syndrome
|
|
Polycystic Ovary Syndrome
|
|
FSH Action in Polycystic Ovary Syndrome
|
|
Dendritic Cell Dysfunction in Psoriatic Arthritis
|
|
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
|
|
Osteoclast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Proteins Involved in Rheumatoid Arthritis
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
WHIM Syndrome
|
|
CD4+ T-Cell Function Decline in HIV
|
|
Macrophage Survival through CCR5 and CXCR4 Mediated Signaling
|
|
Toll-like Receptors (TLR) in Periodontitis
|
|
Diabetes Induced Periodontitis
|
|
Estrogen Effects on Pregnancy Gingivitis
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
TNF Receptor Associated Periodic Syndrome
|
|
Mevalonate Kinase Deficiency
|
|
Blau Syndrome
|
|
Familial Cold Autoinflammatory Syndrome 2
|
|
Hereditary Hemorrhagic Telangiectasia
|
|
Cowden Syndrome
|
|
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
|
|
Huntingtin Mutant Protein Toxicity Effects
|
|
Proteins Involved in Huntington Disease
|
|
IL6 and Insulin Resistance in Muscular Dystrophies
|
|
IL6 Promotes Inflammation in Muscular Dystrophies
|
|
Ca2+ Overload in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
|
|
IGF1 Role in Muscle Hypertrophy
|
|
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
|
|
Osteoblast Function Decline in Osteoporosis
|
|
Osteoclast Activation in Postmenopause
|
|
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
|
|
Proteins Involved in Alzheimer's Disease
|
|
Ketogenic Diet Mechanism (Hypothesis)
|
|
Blood-Brain Barrier Disruption in Epileptiform Disorders
|
|
mTOR Hyperactivation after Status Epilepticus
|
|
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
|
|
Glioblastoma, Primary
|
|
Proteins Involved in Glioblastoma
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Proteins Involved in Astrocytoma
|
|
Glioma Invasion Signaling
|
|
Proteins Involved in Glioma
|
|
Glioma Stem Cell Program Activation
|
|
Ependymoma
|
|
Medulloblastoma
|
|
Proteins Involved in Medulloblastoma
|
|
Vascular Endothelial Cell Vasodilation in Brain
|
|
Dopamine Action in CSD Progression
|
|
Postsynaptic Neuron Activation
|
|
nNOS (NOS1) and iNOS (NOS2) Activation via Glutamate
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
ALK Associated Neuroblastoma
|
|
Sonic Hedgehog Signaling in Neuroblastoma
|
|
Proteins Involved in Neuroblastoma
|
|
Glutamate Role in Parkinson's Disease
|
|
Proteins Involved in Parkinson's Disease
|
|
Proteins Involved in Amyotrophic Lateral Sclerosis
|
|
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
|
|
Microglia and Motor Neuron Interaction Dysregulation
|
|
MIR155 Role in Th17-Cell in Multiple Sclerosis
|
|
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
|
|
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
|
|
WNT Signaling in Breast Cancer
|
|
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Proteins with Altered Expression in Breast Cancer
|
|
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
|
|
Breast Cancer
|
|
ESR1 Signaling in Breast Cancer
|
|
Endometrial Cancer
|
|
Endometrioid Endometrial Cancer
|
|
Proteins Involved in Endometrial Cancer
|
|
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
|
|
Proteins with Altered Expression in Endometrial Cancer
|
|
Proteins Involved in Endometriosis
|
|
Angiogenesis in Endometriosis
|
|
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
|
|
Genes with Mutations Associated with Hereditary Breast and/or Ovarian Cancer Syndrome
|
|
Proteins Involved in High-Grade Serous Ovarian Carcinoma
|
|
Endometrioid Ovarian Carcinoma
|
|
Proteins Involved in Endometrioid Ovarian Carcinoma
|
|
Clear Cell Ovarian Carcinoma
|
|
Proteins Involved in Mucinous Ovarian Carcinoma
|
|
High-Grade Serous Ovarian Carcinoma
|
|
Low-Grade Serous Ovarian Carcinoma
|
|
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
|
|
Ovarian Cancer
|
|
Proteins Involved in Clear Cell Ovarian Carcinoma
|
|
Mucinous Ovarian Carcinoma
|
|
Proteins with Altered Expression in Ovarian Cancer
|
|
Proteins Involved in Primary Ovarian Insufficiency
|
|
LH and FSH Signaling Impairment in Primary Ovarian Insufficiency
|
|
FOXO3 and PTEN Inactivation in Premature Ovarian Failure (Mouse Model)
|
|
MIF Role in Cholesteatoma
|
|
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
|
|
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
Androgen Receptor/Akt Signaling
|
|
Fatty Acid Synthase (FASN) Signaling
|
|
Prostate Cancer
|
|
Androgen Receptor/Protein Kinase C-delta Signaling
|
|
Proteins Involved in Prostate Cancer
|
|
EPHA2 Mutations in Cataract
|
|
Steroids Induced Cataract
|
|
VEGFA in Neovascular Glaucoma
|
|
Glutamate Mediated Excitotoxicity in Glaucoma
|
|
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
|
|
Proteins Involved in Congenital Deafness
|
|
Immune System Role in Otitis Media
|
|
Alveolar Macrophages Dysfunction in COPD
|
|
Proteins Involved in Chronic Obstructive Pulmonary Disease
|
|
T-Cell Cytotoxic Activation
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Polycystins Mutation Effects in Cystic Kidney Disease
|
|
Penile Erection Impairment
|
|
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
|
|
Plasmin Role in Glomerulonephritis
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Proteins with Altered Expression in Prostate Cancer
|
|
Ammonia Effects on Brain Cells
|
|
CD157/ITGB2 Signaling in Myeloid Cell
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
S100P Expression Target
|
|
HMGB1 Expression Targets
|
|
TTR Expression Targets
|
|
S100B Expression Targets
|
|
AREG -> HIF1A Expression Targets
|
|
AREG -> FOXO3A Expression Target
|
|
Noradrenaline/Gs Expression Targets
|
|
Epinephrine/Gs Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
|
|
AGTR1 -> ARRB1/ARRB2 Signaling
|
|
INSR -> ARRB2/AKT/SRC Signaling
|
|
Hedgehog Family -> ARRB1/ARRB2 Canonical Signaling
|
|
CD19 Expression Targets
|
|
CD81 -> AP-1 Expression Targets
|
|
CD19/CR2 Expression Targets
|
|
CCL3L1 Expression Target
|
|
CCL5 Expression Targets
|
|
CCL7 Expression Target
|
|
IL8 Expression Targets
|
|
Tamoxifen Induced Endometrial Cancer
|
|
Dexamethasone Induced Diabetes
|
|
Dexamethasone Induced Osteoporosis
|
|
Doxorubicin Induced Cardiotoxicity
|
|
Ritonavir Induced Diabetes
|
|
Clozapine Induced Granulocytopenia
|
|
Cyclosporine Induced Nephrotoxicity
|
|
EGF -> HIF1A Expression Targets
|
|
EGF -> FOXO3A Expression Targets
|
|
EGFR/ERBB2 -> HIF1A Signaling
|
|
EREG -> FOXO3A Expression Target
|
|
EREG -> HIF1A Expression Target
|
|
Erythropoietin -> FOXO3A Expression Targets
|
|
Erythropoietin -> NF-kB Expression Targets
|
|
PECAM1 Expression Targets
|
|
F2 -> STAT1/NF-kB Expression Targets
|
|
PLG -> STAT1/NF-kB Expression Targets
|
|
FGF2 -> FOXO3A Expression Targets
|
|
FGF7 -> FOXO3A Expression Target
|
|
FGF10 -> FOXO3A Expression Target
|
|
FSHR Expression Targets
|
|
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
HBEGF -> FOXO3A Expression Target
|
|
HBEGF -> HIF1A Expression Targets
|
|
HGF -> FOXO3A Expression Targets
|
|
HGFR -> FOXO3A Signaling
|
|
TAM Receptor Signaling Activation in Cancer
|
|
PI3K/AKT/MTOR Signaling Activation in Cancer
|
|
Hedgehog Signaling Activation in Cancer
|
|
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
|
|
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
|
|
G0/G1 Cell Cycle Phase Transition Activation in Cancer
|
|
RAS/RAF/MAPK Signaling Activation in Cancer
|
|
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
|
|
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
|
|
Hedgehog Signaling Activation by Blocking of Tumor Suppressors
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
|
|
Hippo/YAP1 Signaling Deregulation in Cancer
|
|
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
|
|
Genes with Mutations in Cancer-Associated Resisting to Cell Death
|
|
Apoptosis Evasion in Cancer: Overview
|
|
Hypoxia-Induced Cell Death Evasion in Cancer
|
|
Apoptosis Block by BCL2 Family Proteins in Cancer
|
|
HIF1A in Vasculogenic Mimicry of Cancer
|
|
VEGFA Dependent Angiogenesis in Cancer
|
|
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
|
|
Inhibition of THBS1 Activates Angiogenesis in Cancer
|
|
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
|
|
HIF1A as Master Regulator of Angiogenesis in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
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Integrins in Cancer Cell Motility, Invasion and Survival
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Proteins with Altered Expression in Cancer Metastases
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Epithelial to Mesenchymal Transition in Cancer: Overview
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BSG (CD147) in Cancer Cells Motility, Invasion and Survival
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MTOR/TORC in Cancer Cell Motility and Invasion
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Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
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CDH2 Activation Promotes Cancer Cell Migration and Survival
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TGFB Family in Epithelial to Mesenchymal Transition in Cancer
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Invadopodia Formation in Cancer Cells
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Metabolic Reprogramming in Cancer: Overview
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Skeletal Muscle Wasting in Cancer Cachexia
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Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
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Lipogenesis/Lipolysis Activation in Cancer Cells and Cancer-Associated Adipocytes
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Glycolysis Activation in Cancer (Warburg Effect)
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Genes with Mutations in Cancer Metabolic Reprogramming
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Proteins with Altered Expression in Cancer Metabolic Reprogramming
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Treg Cells Promote Immunosuppression in Cancer Immune Escape
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IDO1 in Cancer Immune Escape
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Effector T-cell Inactivation in Cancer Immune Escape
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EZH2 Methyltransferase Role in Cancer
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DNMT and MBD Families Activation in DNA Methylation in Cancer
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IGF1 -> CEBPA/FOXO1A Expression Targets
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IGF2 -> CEBPA/FOXO1A Expression Targets
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Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
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Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
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CD19 -> NF-kB Signaling
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AGER -> NF-kB Signaling
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ICAM2 -> CTNNB/FOXO/STAT3 Signaling
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InsulinR -> CTNNB/FOXA/FOXO Signaling
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InsulinR -> ELK/SRF/SREBF Signaling
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IGF1R -> CEBPA/FOXO1A Signaling
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FibronectinR -> CTNNB Signaling
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FibronectinR -> NF-kB Signaling
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MacrophageR -> CEBPB -> NF-kB Signaling
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Fibronectin Expression Targets
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CTGF -> FOXO3A Expression Target
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ICAM1 Expression Targets
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Fibrinogen Expression Targets
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IL7R -> FOXO/NF-kB Signaling
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IL15R -> NF-kB/NFATC Signaling
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IL23R -> STAT3/NF-kB Signaling
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IL12R -> NF-kB/NFATC Signaling
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IL7 Expression Targets
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IL15 Expression Targets
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IL12B Expression Targets
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PAF/Gq -> NF-kB Expression Targets
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Elevated Receptors -> Expression Targets in Lymph Node
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CD Markers -> Expression Targets in Lymphoid System and Blood
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NRG1 -> FOXO3A Expression Targets
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NRG1 -> HIF1A Expression Target
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NGF -> FOXO/MYCN/ELK-SRF Expression Targets
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BDNF Expression Targets
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NTF3 Expression Targets
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NOTCH -> NF-kB Signaling
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DLL4 Expression Targets
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ADAM17 Expression Targets
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JAG1 Expression Targets
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DLL1 Expression Targets
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NOTCH Expression Targets
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Adenosine Expression Targets
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PDGFB -> FOXO3A Expression Target
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PDGF -> FOXO3A Expression Targets
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PDGFR -> FOXO3A Signaling
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PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
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PDCD1 -> ATF/CREB/CREBBP Expression Targets
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PDCD1 -> STAT Expression Targets
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GUCYC2 Signaling
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DDR1 -> NF-kB Signaling
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AngiopoietinR -> FOXO Signaling
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GDNF -> HSF1 Signaling
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EphrinB -> MAPK/JUN/FOS Signaling
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NTRK -> FOXO/MYCN Signaling
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CSF1 -> FOXO3A Expression Targets
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Collagen -> NF-kB Expression Targets
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GDNF -> HSF1 Expression Targets
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Lysophosphatidic Acid/LPARs Signaling
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Androgen Receptor non-Genomic Signaling
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FOXO1 Signaling
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MERTK Signaling
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Ras Signaling
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TGF-beta Signaling
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AXL Receptor Tyrosine Kinase Signaling
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PI3K/RAC1 Signaling
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mTOR Signaling
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TNF-alpha/TNFRSF1B Signaling
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KRAS Signaling
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VEGF Signaling
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Estrogens/ESR1 non-Genomic Signaling
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EGFR Signaling
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HRAS Signaling
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Hedgehog Family Signaling
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T-Cell Receptor -> NF-kB Signaling
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TGFA -> FOXO3A Expression Targets
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TGFA -> HIF1A Expression Targets
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TNFSF10 Expression Targets
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CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
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TNFSF13B Expression Targets
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TNF -> STAT Expression Targets
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TNFRSF5/13B -> NFATC1 Signaling
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Thrombopoietin -> SPI1 Expression Targets
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Thrombopoietin -> FOXO3A Expression Target
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TLR1 -> 2/6 Expression Targets
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TLR1/2/6 -> NF-kB Signaling
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ER Stress (Unfolded Protein Response)
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Glutamate Mediated Neurotoxicity
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Ca2+ Cytosolic Overload
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ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
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VEGFC -> CTNNB Expression Target
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VEGFA -> FOXO3A Expression Targets
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VEGFA -> CTNNB/CTNND Expression Targets
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VEGFR -> CTNNB Signaling
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VEGFR -> FOXO3A Signaling
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n
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ace2
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cypa
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pprarg neg, uknown targets, ps-positive
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Model of PPARG signaling in psoriasis
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Model of PPARG related pathways in psoriasis (short version)
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New Pathway (4)
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H2A-K120, H2A-K119 and H3-K4
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Epigenetic Modifications of H2A-K120, H2A-K119 and H3-K4
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3_Increased proliferation of sebocytes in acne vulgaris
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2_Interleukin-17 and interleukin-22 signaling in psoriasis
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1_The onset of atopic dermatitis
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1_Osteoclast-mediated bone resorption in postmenopausal women
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2_Osteoblast-mediated bone demineralization
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3_TGFB signaling provokes endochondral ossification with osteophyte formation
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1_Local estrogen production stimulates ectopic endometrium proliferation
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3_Enhanced angiogenesis in endometriosis
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2_Impaired steroidogenesis in PCOS
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3_Role of neurotrophic factor deprivation in retinal ganglion cell death
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3_Arterial wall inflammation and calcification in atherosclerosis
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2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
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1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
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2_Cardiomyocyte hypertrophy
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4_Endothelial cells repress vasoconstriction in hypertension
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1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
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3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
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1_Th2 cell response in asthma
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2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
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4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
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2_Intestine epithelial cells drive immunological responses in ulcerative colitis
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1_Triglyceride storage in NAFLD
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1_CD4+ T cell and epithelial cell response in celiac disease
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4_Tax-induced disruption of the G1/S transition in HTLV-1 infected T-cell
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2_HIV - induced depletion of CD4+ T-cells
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3_1_Beta-cell proliferation and compensation: proliferation
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1_1_Insulin synthesis and secretion: insulin processing and storage
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3_3_Beta-cell proliferation and compensation: recovery
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4_2_Insulin resistance: inflammation-related insulin resistance
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4_1_Insulin resistance: insulin signaling
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4_3_Insulin resistance: FFA-related insulin resistance
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1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
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1_Microangiopathy in diabetic neuropathy
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2_Neuron and Schwann cell death
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1_Glutamate and calcium excitotoxicity of motor neurons in ALS
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1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
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2_1_General pathways of thyroid hormone signaling
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drug-target pairs direct regulation
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New Combined Pathway
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Model of PPARG signaling in psoriais (tested)
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DIPG overview_1 (histones)
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DIPG non histone mutations
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DIPG histone 3 mutations
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New Pathway
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DIPG overview_2
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HRAS->RAF->MAPK1/3
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mapk1 protein modificators
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Interleukin-17 and interleukin-22 signaling in psoriasis
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