Protein IL36A

URN urn:agi-llid:27179
Total Entities 0
Connectivity 286
Name IL36A
Description interleukin 36 alpha
Notes The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
Primary Cell Localization Extracellular
Class Ligand

Pathway Proteins Involved in Psoriatic Arthritis
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
NOTCH -> Expression Targets in Skin
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of lethality
Neighbors of neutrophil count
Neighbors of mortality rate
Neighbors of skin thickness
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of lethality
Neighbors of neutrophil count
Neighbors of mortality rate
Neighbors of skin thickness
Neighbors of cell development
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of innate immune response
Neighbors of macrophage activation
Neighbors of adaptive immune response
Neighbors of chemotaxis
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of cell count
Neighbors of adipogenesis
Neighbors of cell motility
Neighbors of adipocyte differentiation
Neighbors of neutrophil recruitment
Neighbors of phagocytosis
Neighbors of cell growth
Neighbors of cell differentiation
Neighbors of psoriasis
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of multiple sclerosis
Neighbors of inflammation
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of reperfusion injury
Neighbors of infection
Neighbors of macrophage infiltration
Neighbors of sepsis
Neighbors of dermatitis
Neighbors of colorectal cancer
Neighbors of systemic lupus erythematosus
Neighbors of interstitial fibrosis
Neighbors of neoplasm
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of macrophage
Neighbors of airway epithelial cell
Neighbors of pneumocyte
Neighbors of intestine epithelium cell
Neighbors of dendritic cell
Neighbors of neutrophil
Neighbors of bone
Neighbors of NF-kB family
Neighbors of interleukin
Neighbors of Notch
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)

MedScan ID 27179

LocusLink ID 27179
54448
296541

Alias FIL1E
MGC151479
MGC129552
interleukin 1 family, member 6 (epsilon)
interleukin IL1F6
interleukin 1 family, member 6
MGC129553
interleukin 36, alpha
LOC83004
RP23-176J12.4
IL1F6
MGC151481
Il36a
interleukin IL-1f6 (fil-1-epsilon)
IL-1f6 (fil-1-epsilon)
OTTMUSP00000012798
interleukin 1 family, member VI
FIL1(EPSILON)
FIL1
IL-1F6
IL1(EPSILON)
FIL1 epsilon
IL-1 epsilon
interleukin-1 epsilon
interleukin-1 family member 6
interleukin-36 alpha
Il1f9
IL-1H1
IL1RP2
Fil1epsilon
interleukin 1 family, member 9
interleukin-1 homolog 1
Il1h1

GO ID 0005125
0005149
0071222
0019221
0006955
0006954
0045087
0030593
0043123
0046330
0032755
0005576
0005615
0002376
0001819
0010469

KEGG ID hsa:27179
mmu:54448

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}

Mouse chromosome position 2 16.26 cM

OMIM ID 605509

Rat chromosome position 3p13

Hugo ID 15562

Human chromosome position 2q14.1

Swiss-Prot Accession Q9UHA7
Q9UHA7.1
Q149U6
Q9JLA2
Q9JLA2.1
D4A1I2
B2RAD9
Q53SR7
Q5BLR4
Q7RTZ8

GenBank ID NC_000002
NM_014440
NP_055255
XM_011510965
XP_011509267
XM_005263639
XP_005263696
XM_017003806
XP_016859295
AC016724
AAY14988
AY944686
AAX20113
BN000002
CAD29875
CH471217
EAW73614
AF201831
AAF25211
AK314149
BAG36836
BC107042
AAI07043
BC107043
AAI07044
Q9UHA7
NC_000068
NM_019450
NP_062323
AL732430
CH466542
EDL08163
AF200493
AAF69249
AF206697
AAG35671
AK004061
BAB23147
AK224928
AK224929
AK224931
AK224932
BC117102
AAI17103
BC117104
AAI17105
KM205447
AKA62187
KM205448
AKA62188
Q9JLA2
NC_005102
XM_008761581
XP_008759803
NM_001106554
NP_001100024
AC_000071
AABR07051212
AAHX01020410
CH474001
EDL93670

Swiss-Prot ID IL36A_HUMAN
IL36A_MOUSE

Cell Localization Secreted

Ensembl ID ENSG00000136694
ENSP00000259211.6
ENST00000259211.6
ENSMUSG00000026984
ENSMUSP00000028361.4
ENSMUST00000028361.4
ENSRNOG00000005722
ENSRNOP00000007540.4
ENSRNOT00000007540.5

MGI ID MGI:1859324

RGD ID 1306869