Protein TRAF3IP2

URN urn:agi-llid:10756
Total Entities 0
Connectivity 530
Name TRAF3IP2
Description TRAF3 interacting protein 2
Notes This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Pathway Proteins Involved in Myocardial Ischemia
IL17 Signaling in Psoriasis
Genes with Mutations Associated with Psoriasis
Il17 Signaling Related Neutrophilia in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Cytokines Trigger Otitis Media
IL23A and IL17A Provoke Cancer-Associated Inflammation
2_Interleukin-17 and interleukin-22 signaling in psoriasis
3_2_Regulation of airway surface liquid (ASL) thickness
4_1_Polymorphisms associated with inflammatory bowel diseases
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Psoriasis
Genes with Mutations Associated with Psoriatic Arthritis

MedScan ID 10756

LocusLink ID 10756
10758
103213
361857

Alias OTTHUMP00000017022
RP3-487J7.3
Ciks
C6orf2
traf3ip2
OTTHUMP00000017024
NFkB-activating protein ACT I
chromosome 6 open reading frame 6
C6orf5
MGC3581
AI429613
chromosome 6 open reading frame II
CANDF8
chromosome 6 open reading frame 5
ACT1
traf3 interacting protein 2
NFkB-activating protein ACT1
traf3 interacting protein II
chromosome 6 open reading frame V
DKFZP586G0522
PSORS13
nuclear factor NF-kappa-B activator 1
C6orf6
RGD1304768
C6orf4
chromosome 6 open reading frame 4
chromosome 6 open reading frame IV
chromosome 6 open reading frame 2
MGC112844
connection to IKK and SAPK/JNK
ACT I
OTTHUMP00000040422
adaptor protein CIKS
adapter protein CIKS

GO ID 0005102
0001783
0006959
0048305
0035556
0043123
0002230
0005622
0005623

KEGG ID hsa:10758

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 10

OMIM ID 607043
615527
614070

Rat chromosome position 20q12

Hugo ID 1343
HGNC:1343

Human chromosome position 6q21

Swiss-Prot Accession O43734
O43734.3
Q8N7N6
Q498R8
B2RAY9
E1P555
Q5R3A3
Q7Z6Q1
Q7Z6Q2
Q7Z6Q3
Q9H5W2
Q9H6Y3
Q9NS14
Q9UG72

PIR ID T08794

GenBank ID NC_000006
NM_001164281
NP_001157753
NM_147686
NP_679211
NM_147200
NP_671733
NM_001164283
NP_001157755
NG_032030
AL008730
CH471051
EAW48285
EAW48286
EAW48287
EAW48288
CS135278
CAJ21527
Z97989
AF085921
AF136405
AAF67445
AF136406
AAF67446
AF136407
AAF67447
AF272151
AAG15407
AF274303
AAG15367
AK025351
BAB15117
AK026602
BAB15507
AK310141
AK310922
AK314415
BAG37036
AL050289
CAB43390
AW296296
AW513823
BC002823
AAH02823
BC026723
BE904103
BI856094
BM449775
CB049654
DA130363
DA665549
DA836923
DC348710
DT217829
O43734
NC_000076
NM_134000
NP_598761
XM_011243105
XP_011241407
AC160403
CH466540
EDL04930
KC414133
AB238206
BAF34919
AB238207
BAF34920
AK031556
BAC27449
AK037407
BAC29801
AK052190
BAC34875
AK098107
BAC05236
BC008534
BC008535
BC022633
AAH22633
BC071207
AAH71207
BC096483
AAH96483
BC138234
AAI38235
BC138235
AAI38236
JX869941
AFY98903
NC_005119
XR_597418
XR_597419
NM_001044248
NP_001037713
XM_006256532
XP_006256594
AC_000088
AABR07045351
AABR07045352
AAHX01101535
AAHX01101536
AAHX01101537
CH474051
EDL87824
EDL87825
BC100099
AAI00100
NR_028338
XM_011535386
XP_011533688
XM_006715319
XP_006715382
NC_018917
AMYH02014306
JF432241
ADZ15458
AC_000032
AAHY01084885
AAHY01084886
AAHY01084887
AAHY01084888
XM_006256533
XP_006256595
AC_000138
ABBA01026085
ABBA01026086
XM_006512495
XP_006512558

Swiss-Prot ID CIKS_HUMAN

Ensembl ID ENSG00000056972
ENSP00000352889.4
ENST00000359831.8
ENSP00000357724.1
ENST00000368735.1
ENSP00000345984.6
ENST00000340026.10
ENSP00000357750.5
ENST00000368761.10
ENSMUSG00000019842
ENSMUSP00000019987.6
ENSMUST00000019987.6
ENSRNOG00000000595
ENSRNOP00000000728.5
ENSRNOT00000000728.5
ENSP00000352889
ENST00000359831
ENSP00000357724
ENST00000368735
ENSP00000357750
ENST00000368761
ENSP00000345984
ENST00000340026
ENSMUSP00000019987
ENSMUST00000019987
ENSRNOP00000000728
ENSRNOT00000000728

MGI ID MGI:2143599

RGD ID 1593240

Unigene ID Hs.561514
Hs.740602
Mm.436686
Rn.9031

Homologene ID 15885