Small Molecule prostaglandin E2

URN urn:agi-cas:363-24-6
Total Entities 7
Connectivity 9002
Name prostaglandin E2
Description prostaglandine E2
Class Endogenous compound
Molecular Weight 352.465080
XLogP 2.800000

ChildConcepts PGD3
PGD2
PGF2alpha
PGA2
8-epi-PGF2alpha
8-iso-PGE2
PGD1

Pathway Bradykinin Effects in Inflammation
Platelet Activation via GPCR Signaling
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
Prostaglandin E2 Receptor Signaling in Neurons
Eicosanoids in Myeloid Cell Activation
Eicosanoids in Inflammation
Prostaglandin E2 and Histamine in Gastric Acid Secretion
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Vasodilation Activation
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Lipolysis Regulation in Adipocyte
Nociception Expression Targets Signaling
Vascular Motility
Ca2+ Flux Regulation
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
Luteinizing Hormone in Oocyte Meiotic Resumption
Prostaglandins Role in Sleep Regulation
Hematopoietic Cell Lineage: B-cell
Arterial Hypertension
T-Cells Differentiation Block in Psoriasis
Metastatic Colorectal Cancer
Goblet-Cell Related Mucus Secretion in Asthma
Osteoclast Activation in Gout
Monocytes Function in Gout
IL1B Induced Arthralgia
Vascular Endothelial Cell Vasodilation in Brain
Dopamine Action in CSD Progression
Postsynaptic Neuron Activation
eNOS (NOS3) Activation via Prostaglandin E2 and Histamine
Prostaglandin E2 Synthesis Activation via Glutamate in Familial Hemiplegic Migraine
Neuroinflammation in Amyotrophic Lateral Sclerosis
Local Estrogen Production in Endometriosis
Angiogenesis in Endometriosis
BMP Signaling Impairment in Granulosa Cell in POF
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Sertoli Cells Dysfunction Causes Male Infertility
Aryl Hydrocarbon Receptor/Arachidonic Acid Metabolites Signaling
Valdecoxib Induced Ischemic Disease
EGFR Transactivation in Cancer and Non-Cancer Cells
IL23A and IL17A Provoke Cancer-Associated Inflammation
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
Arachidonic Acid Metabolism
IL1B -> PGE2 Expression Targets
ROS and RNS in Vasoconstriction and Vasodilation Regulation
PPAR Psoriasis
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
4_Endothelial cells repress vasoconstriction in hypertension
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
1_2_Glutamate overload and NO-mediated vasodilation
Differentiation of psoriatic T cells

MedScan ID 1215412

Alias Prostaglandins E2
propess
L-PGE2
[1-14C]prostaglandin E2
(e,z)-(1r,2r, 3r)-7-[3-hydroxy-2-[(3s)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]- 5-heptenoic acid
Prostaglandin E2
urinary prostaglandin E2
prostin E2 vaginal cream
[12C]prostaglandin E2
(e,z)-(1r,2r, 3r)-7-(3-hydroxy-2-((3s)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)- 5-heptenoic acid
prostaglandin E II
U 12062
cerviprime
prostine
prostaglandin (PG) E2
Prepidil Gel
(e,z)-(1r,2r,3r,5s)-7-(3-hydroxy-2-((3s)-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
prostin E2 tab
363-24-6
Prostin
postaglandin E2
(5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoate
PG007
dinoprostone gel
Prostaglandin PGE2
l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoate
NSC 165560
minprostin e 2
U-12062
(e,z)-(1r,2r,3r,5s)-7-[3-hydroxy-2-[(3s)-(3-hydroxy-1-octenyl]-5-oxocyclopentyl]-5-heptenoic acid
(15S)-Prostaglandin E2
(5z,11a,13e,15s)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
uPGE2
Prepidil
Dinoprostone
Dinoprostona
(e,z)-(1r,2r,3r,5s)-7-(3-hydroxy-2-((3s)-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoate
7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid
prostaglandin (PG) E2alpha
(e,z)-(1r,2r,3r,5s)-7-[3-hydroxy-2-[(3s)-(3-hydroxy-1-octenyl]-5-oxocyclopentyl]-5-heptenoate
Dinoproston
(5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oate
dinoprostone sodium
L-Prostaglandin E2
(5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
Cervidil
uPGE(2)
primiprost
prostin R
7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoate
11,15 dihydroxy 9 oxoprosta 5,13 dien 1 oic acid
prostin 3
(5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic
U,12, 062
prostarmon E
PGE2
ORG2634
dinoprostin
(e,z)-(1r,2r, 3r)-7-(3-hydroxy-2-((3s)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)- 5-heptenoate
l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
prostin E2 vaginal gel
(5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
(5z,13e)-(15s)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
(5z,13e)-(15s)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
minprostin
PGE2alpha
(e,z)-(1r,2r, 3r)-7-[3-hydroxy-2-[(3s)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]- 5-heptenoate
Dinoprostonum
Prostenon
EINECS 206-656-6
(5z,11a,13e,15s)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate
Prostaglandin E2 alpha
Prostin E2
PGE(2)
prandin E2
prostaglandine E2 alpha
L-Prostaglandine E2
prostaglandine E2
prostaglandine (PG) E2alpha
prostaglandine (PG) E2
prostaglandin gel
prostaglandin pessary
minprostin E2
Minprositin E2
minproistin E2
5-heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)
5-heptenoic acid,7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l

CAS ID 363-24-6

Reaxys ID 2224720
2224721
2224722
2224723
2224724
2421225
2705862
2705863
2819704
2819705
2819706
2819707
2819708
2819709
2819710
2819711
2819712
2819713
2950614
2950615
2950616
2950617
2950618
2950619
2950620
2950621
2950622
2950623
3037904
3037905
3037906
4152491
4152492
4152493
4152494
4152495
4709355

ChEBI ID 15551

PharmaPendium ID Dinoprostone

HMDB ID HMDB01220
HMDB12580
HMDB12601
HMDB12638
HMDB12777
HMDB12855

KEGG ID C00584

InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N

Molecular Formula C20H32O5

PubChem SID 134973974
152904

PubChem CID 5280360

IUPAC Name (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-keto-cyclopentyl]hept-5-enoic acid

Rotatable Bond Count 12

PharmaPendium Name Dinoprostone