URN | urn:agi-llid:4484 |
---|---|
Total Entities | 0 |
Connectivity | 3496 |
Name | TGFBR1 |
Description | transforming growth factor beta receptor I |
Notes | The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
Pathway | Osteoarthritis |
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Immunoglobulin Class-Switch Recombination Activation | |
Treg-Cell Differentiation | |
AHR Signaling in Treg and Dendritic Cells Function | |
AHR Signaling in Th17 Cells Function | |
Th17-Cell Differentiation | |
anti-Inflammatory Function of Macrophage M2 Lineage | |
Vascular Endothelial Cell Activation by Growth Factors | |
Vascular Smooth Muscle Cell/Pericyte Differentiation and Proliferation | |
PRL Expression Regulation by BMP4 and TGFB1 | |
G1/S Damage Checkpoint | |
Cell Cycle Overiew | |
Transcytosis | |
Cardiomyocyte Dysfunction | |
Dilated Cardiomyopathy | |
Cardiomyocyte Hypertrophy | |
Hypertrophic Cardiomyopathy | |
Proteins Involved in Pulmonary Hypertension | |
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Hair Follicle Keratinocyte Apoptosis | |
Androgens in Sebocyte Maturation | |
Androgens Promote Scalp Dermal Papilla Regression | |
T-Cells Differentiation Block in Psoriasis | |
TGF-beta Signaling in Skin Aging | |
Treg-Cell Function in Diabetes Mellitus Type 1 | |
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1 | |
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model) | |
Treg-Cell Activation in Diabetes Mellitus | |
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy | |
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy | |
Proteins Involved in Diabetic Nephropathy | |
Mesangial Cell Dysfunction in Diabetic Nephropathy | |
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease | |
Metastatic Colorectal Cancer | |
GUCY2C Signaling in Colorectal Cancer | |
Th17-Cell Activation in Crohn's Disease | |
Chronic Myeloid Leukemia | |
Proteins Involved in Hepatocellular Carcinoma | |
Hepatocellular Carcinoma | |
Growth Factor Signaling in Hepatocellular Carcinoma | |
Proteins Involved in Pancreatic Cancer | |
Pancreatic Ductal Carcinoma | |
Pancreatic Neuroendocrine Tumors | |
TGFBR Signaling in Pancreatic Neoplasms | |
ADAM33 Role in Asthma | |
Th17-Cell Differentiation in Asthma | |
Osteoblast Function Decline in Gout | |
TGFB2 Signaling Impairement in Osteoarthritis | |
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis | |
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma | |
Skin Fibrosis | |
Th17-Cell Numbers Reduction in HIV | |
Hereditary Hemorrhagic Telangiectasia | |
Myostatin in Skeletal Muscles in Muscular Dystrophies | |
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies | |
Proteins with Altered Expression in Osteoarthritis | |
Bone Loss in Osteoporosis | |
Hyperparathyroidism, Secondary Effect | |
Blood-Brain Barrier Disruption in Epileptiform Disorders | |
Glioma Stem Cell Program Activation | |
Medulloblastoma | |
Proteins with Altered Expression in Breast Cancer | |
Breast Cancer | |
Ovarian Cancer | |
Proteins with Altered Expression in Ovarian Cancer | |
BMP Signaling Impairment in Granulosa Cell in POF | |
Prostate Cancer | |
Proteins Involved in Prostate Cancer | |
Cytokines Trigger Otitis Media | |
Podocyte Dysfunction in Glomerulonephritis | |
Mesangial Cell Dysfunction in Glomerulonephritis | |
Interstitial Fibroblasts in Pyelonephritis | |
TGFBR3 -> ARRB2 Signaling | |
Dexamethasone Induced Osteoporosis | |
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling | |
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling | |
DNA Damage Checkpoint Impairment in Cancer | |
IL23A and IL17A Provoke Cancer-Associated Inflammation | |
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression | |
TGFB Signaling activation by Blocking of Tumor Suppressors | |
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors | |
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors | |
HIF1A in Vasculogenic Mimicry of Cancer | |
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer | |
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival | |
TGFB Family in Epithelial to Mesenchymal Transition in Cancer | |
Invadopodia Formation in Cancer Cells | |
Skeletal Muscle Wasting in Cancer Cachexia | |
Treg Cells Promote Immunosuppression in Cancer Immune Escape | |
TGFBR -> AP-1 Signaling | |
TGFBR/BMPR -> SMAD2/3 Signaling | |
TGFBR -> CREB/ELK-SRF Signaling | |
TGFBR -> ATF/GADD/MAX/TP53 Signaling | |
TGFBR -> MEF/MYOD/MYOG Signaling | |
TGFBR1/AP-1 Signaling | |
TGF-beta Signaling | |
TGFB2-TGFBR1 Expression Targets | |
TGFB3-TGFBR1 Expression Targets | |
TGFB1-TGFBR1 Expression Targets | |
TGFB1-TGFBR1/AP-1 Expression Targets | |
PPAR Psoriasis | |
prarg negative regulators, ps-positive | |
Model of PPARG signaling in psoriasis | |
PPARG negative regulators and targets | |
Model of PPARG related pathways in psoriasis (short version) | |
1_Differentiation of psoriatic T cells | |
3_TGFB signaling provokes endochondral ossification with osteophyte formation | |
3_The role of interstitial fibroblasts in pyelonephritis | |
3_Mesangial cell dysfunction in glomerulonephritis | |
2_Podocyte dysfunction in glomerulonephritis | |
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension | |
2_Cardiomyocyte hypertrophy | |
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD | |
4_2_Genes with mutations currently associated with ulcerative colitis | |
4_1_Polymorphisms associated with inflammatory bowel diseases | |
2_Defective tolerance of autoreactive T-cell in T1D | |
Differentiation of psoriatic T cells |
Group | Genes with Susceptibility Loci Associated with Age-Related Macular Degeneration |
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Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis |
MedScan ID | 4484 |
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LocusLink ID | 4484 |
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7046 | |
21812 | |
29591 |
Alias | T beta R-I |
---|---|
TGF-beta type I and activin receptors | |
Transforming Growth Factor-beta RI | |
OTTMUSP00000007207 | |
OTTHUMP00000021783 | |
AU017191 | |
activin A receptor type II-like kinase, 53kD | |
transforming growth factor beta (TGF-beta) receptor type I | |
TGF-beta R I | |
TGF-beta type I and activin receptor | |
TGF-beta 1 receptor | |
Tgfbr I | |
ESK2 | |
OTTMUSP00000007205 | |
activin A receptor type II-like kinase | |
ALK V | |
MSSE gene | |
TGFR-1 | |
TGF-beta 1 receptors | |
AAT5 | |
TbetaRI | |
TGF-beta I receptors | |
TGFR I | |
RP23-457P12.1 | |
transforming growth factor-beta serine/threonine type I receptors | |
TGF-beta type I receptor | |
type I transforming growth factor-beta receptor | |
ESS I | |
TGF-beta 1Rs | |
Transforming Growth Factor-beta R I | |
MGC93659 | |
activin A receptor type II-like kinase, 53kDa | |
Activin receptor-like kinase 5 | |
transforming growth factor beta receptor I | |
TGF-beta receptor type I | |
type I transforming growth factor-beta receptors | |
multiple self-healing squamous epithelioma gene | |
LDS2A | |
transforming growth factor beta 1 receptor | |
transforming growth factor beta 1 receptors | |
T beta RI | |
LOC666236 | |
ALK-5 | |
TGFb1R | |
TGF-beta RI | |
multiple self-healing squamous epithelioma protein | |
LOC669553 | |
TbetaR-I | |
ESS1 | |
SKR4 | |
LOC674605 | |
TGFBR1 | |
LDS1A | |
transforming growth factor-beta serine/threonine type I receptor | |
TGF-beta 1R | |
TGFb1Rs | |
TGR1_HUMAN | |
RP11-96L7.1 | |
TGF-beta receptor type-1 | |
TGR I | |
TBRI | |
Serine/threonine-protein kinase receptor R4 | |
Activin receptor-like kinase V | |
transforming growth factor, beta receptor 1 | |
TGR1 | |
ALK5 | |
LDS1 | |
MSSE | |
TBR-i | |
ACVRLK4 | |
activin A receptor type II-like protein kinase of 53kD | |
mutant transforming growth factor beta receptor I | |
transforming growth factor-beta receptor type I | |
transforming growth factor, beta receptor I | |
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) |
EC Number | 2.7.11.30 |
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GO ID | 0005524 |
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0070411 | |
0046332 | |
0048185 | |
0019838 | |
0046872 | |
0004672 | |
0004674 | |
0050431 | |
0005025 | |
0005024 | |
0005114 | |
0000186 | |
0032924 | |
0060978 | |
0009952 | |
0006915 | |
0048844 | |
0001824 | |
0060317 | |
0007050 | |
0048870 | |
0071560 | |
0030199 | |
0060982 | |
0048701 | |
0042118 | |
0043542 | |
1905223 | |
0001837 | |
0043062 | |
0008354 | |
0007507 | |
0001701 | |
0035556 | |
0001822 | |
0002088 | |
0008584 | |
0048762 | |
0032331 | |
0001937 | |
2001237 | |
0030512 | |
0048663 | |
0060017 | |
0060389 | |
0007389 | |
0018105 | |
0018107 | |
0060037 | |
0060391 | |
2001235 | |
0030307 | |
0030335 | |
0008284 | |
0051272 | |
0001938 | |
0010718 | |
1905007 | |
0051491 | |
0010628 | |
0010862 | |
0051897 | |
0051496 | |
1905075 | |
0045893 | |
0009791 | |
0003342 | |
0016579 | |
0006468 | |
0060043 | |
0010717 | |
0043393 | |
0031396 | |
0006355 | |
0070723 | |
0060021 | |
0007165 | |
0001501 | |
0048705 | |
0048538 | |
0007179 | |
0003223 | |
0060412 | |
0003222 | |
0042060 | |
0048179 | |
0005923 | |
0009986 | |
0005768 | |
0005887 | |
0043231 | |
0045121 | |
0005634 | |
0005886 | |
0043235 | |
0016301 | |
0000166 | |
0046982 | |
0044877 | |
0005102 | |
0016740 | |
0004675 | |
0031625 | |
0001525 | |
0030154 | |
0043066 | |
0045602 | |
1902894 | |
0016310 | |
0043065 | |
1902895 | |
0046777 | |
0010468 | |
0040008 | |
0043627 | |
0007178 | |
0016324 | |
0016323 | |
0005901 | |
0030054 | |
0016021 | |
0016020 | |
0032991 | |
0007568 | |
0031100 | |
0048565 | |
0007566 | |
0030324 | |
0051602 | |
0001666 | |
0014070 | |
0034695 | |
0009636 | |
0005623 | |
0005622 | |
0070022 | |
0005057 | |
0004702 | |
0023014 | |
0032403 | |
0009790 | |
0043234 | |
0016772 |
KEGG ID | hsa:7046 |
---|---|
mmu:21812 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 4 26.02 cM |
---|
OMIM ID | 190181 |
---|---|
609192 | |
132800 |
Rat chromosome position | 5q22 |
---|
Hugo ID | 11772 |
---|---|
HGNC:11772 |
Human chromosome position | 9q22.33 |
---|---|
9q22 |
Swiss-Prot Accession | B4DXN7 |
---|---|
P36897 | |
Q5T7S2 | |
B4DY26 | |
P36897.1 | |
Q64729 | |
Q9D5H8 | |
Q4FJL1 | |
Q64729.1 | |
Q5M9H3 | |
P80204 | |
P80204.1 | |
Q6IR47 | |
Q706C0 | |
Q706C1 | |
A2AJN0 |
PIR ID | A49432 |
---|---|
JC2061 | |
JC2062 |
Swiss-Prot ID | TGFR1_HUMAN |
---|---|
TGFR1_MOUSE | |
TGFR1_RAT |
Cell Localization | Cell membrane |
---|---|
Cell junction | |
Tight junction | |
Cell surface | |
Membrane raft | |
Cell junction, tight junction |
Ensembl ID | ENSG00000106799 |
---|---|
ENSP00000364129.2 | |
ENST00000374990.6 | |
ENSP00000447297.1 | |
ENST00000552516.5 | |
ENSP00000364133.4 | |
ENST00000374994.9 | |
ENSP00000450052.1 | |
ENST00000550253.1 | |
ENSMUSG00000007613 | |
ENSMUSP00000048501.7 | |
ENSMUST00000044234.13 | |
ENSMUSP00000103353.2 | |
ENSMUST00000107725.2 | |
ENSMUSP00000007757.8 | |
ENSMUST00000007757.14 | |
ENSMUSP00000123761.1 | |
ENSMUST00000126171.8 | |
ENSRNOG00000007036 | |
ENSRNOP00000071347.1 | |
ENSRNOT00000081090.1 | |
ENST00000374994.8 | |
ENSP00000364129 | |
ENST00000374990 | |
ENSP00000364133 | |
ENST00000374994 | |
ENSP00000450052 | |
ENST00000550253 | |
ENSP00000447297 | |
ENST00000552516 | |
ENSMUSP00000007757 | |
ENSMUST00000007757 | |
ENSMUSP00000048501 | |
ENSMUST00000044234 | |
ENSRNOP00000071347 | |
ENSRNOT00000081090 | |
ENSRNOG00000050760 |
MGI ID | MGI:98728 |
---|
RGD ID | 3852 |
---|
Unigene ID | Rn.44402 |
---|---|
Hs.494622 | |
Mm.197552 |
Homologene ID | 3177 |
---|
Shape | Stick-vertex |
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