Pathway
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Melatonin Effects on Circadian Cycle
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High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
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GCG and PPY Regulate Metabolism and Satiety
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Ghrelin and Nesfatin-1 Regulate Stomach Functional State and Satiety
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mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
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Ghrelin and SST Regulate GH1 Release in Hypothalamus
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Taste Receptors Activation in Tongue
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L-cell: GCG, PYY and 5-HT Release
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I-cell: CCK-8 Secretion and Regulation of Eating Behavior
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A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
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G-cell: Gastrin Secretion
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N-cell: Neurotensin Production
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Dopamine Receptors Signaling
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Serotonin Receptors Signaling
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CXC Chemokine Receptor Signaling
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CC Chemokine Receptor Signaling
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Proplatelet Maturation
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Platelet Activation via GPCR Signaling
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Leukotriene Effect on Vascular Endothelial Cell Response
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Eicosanoids in Myeloid Cell Activation
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Leukotriene Effect on Airway Smooth Muscle Response
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Histamine Receptor H3 Signaling in Neurons
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Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
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Basophil Activation
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Eosinophil Activation
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Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
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Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
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Neutrophil Recruitment and Priming
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Neutrophil Degranulation via FPR1 Signaling
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CR3 Mediated Phagocytosis in Neutrophils and Macrophages
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Neutrophil Chemotaxis
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Neutrophil Activation via Adherence on Endothelial Cells
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Vascular Endothelial Cell Activation by NO
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Vascular Endothelial Cell Activation by Cytokines
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Lipolysis Regulation in Adipocyte
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Potassium Flux Regulation
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Nociception Expression Targets Signaling
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Sodium Flux Regulation
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Vascular Motility
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Ca2+ Flux Regulation
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TAAR1 -> Neurotransmitter Uptake
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NPY1R -> CRH/POMC Production
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EDNRA/B -> Vascular Motility
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ADORA1/2A -> Exocytosis
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ADORA3 -> Mast-Cell Degranulation
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ADRA2A -> Neurotransmitter Release
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ADRB1 -> Prostaglandin Generation
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BDKRB1/2 -> Vasodilation
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BDKRB1/2 -> Ion Channels
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BDKRB1/2 -> Prostaglandin Generation
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BDKRB1/2 -> Interleukins Production
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CNR1/2 -> Membrane Transport
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CNR1/2 -> Vascular Motility
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CNR1/2 -> IL1B/2/4/6/10 Production
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DRD3 -> Dopamine Uptake
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DRD2 Expression Targets
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DRD1/3 -> Potassium Uptake
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DRD2/4 -> Membrane Transport
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GALR1/2/3 -> POMC/NPY Production
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HRH1/2 -> Vascular Motility
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HRH2/4 -> IL6/10 Production
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CHRM1 -> IL2 Production
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CHRM1/2/3/5 -> Ion Channels
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CHRM1/2/3 -> Vascular Motility
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OPRD/OPRM -> Ion Channels
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OPRK -> Pain Perception
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OPRL1 -> Ion Channels
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PTGER2/3 -> Vascular Motility
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PTGER2/3 -> Inflammation-Related Expression Targets
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HTR1 -> IL6 Production
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HTR5 -> TNF Production
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HTR2 -> Membrane Transport
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HTR1 -> Membrane Transport
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HTR1 -> Vascular Motility
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TACR1 -> TNF/IL6/IL8 Production
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GABA(B)R -> Postsynaptic Inhibition
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GRM1/5 (Postsynaptic) -> Ion Channels
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P2RY2/12/13/14 -> N-Type Calcium Channel
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P2RY1/2/4/6 -> Potassium Channels
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Melatonin in Cell Survival and Antioxidant Response
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Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
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Hypocretin (Orexin) in Arousal Regulation
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Dilated Cardiomyopathy
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Cardiomyocyte Hypertrophy
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Hypertrophic Cardiomyopathy
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Endothelial Cell Dysfunction in Pulmonary Hypertension
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Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
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Vascular Reactivity in Raynaud Disease
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NO Synthesis in Early Vasospasm
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Contraction Due Vasospasm
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Melanoma
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MITF as a Regulator of Melanoma Cell Development
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Oxidative Stress in Vitiligo
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Vitiligo
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G-Proteins Signaling in Insulin Secretion in beta-Cell
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Metastatic Colorectal Cancer
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Antiphospholipid Antibodies in Platelets and Coagulation Cascade
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Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
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Eosinophil Activation and Degranulation in Asthma
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Airway Smooth Muscle Cell High Rate Proliferation
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Airway Smooth Muscle Cell Contraction
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Neutrophil Degranulation via FPR1/IL8
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Basophil Activation in Asthma
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Mast-Cell Related Chemokines Signaling in Asthma
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Skin Fibrosis
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ADK Expression Upregulation
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CCL2 Role in CGRP Expression and Release
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Vascular Smooth Muscle Cell Vasodilation in Brain
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NO Effect on Vasodilation and Vasoconstriction
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Hypocretin Elevation and Monoamine Oxidase Decrease/Inhibition
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Sleep Disturbance (Hypothesis)
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MIF Role in Cholesteatoma
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Cholesteatoma
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Prostate Cancer
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Muscarinic Receptor-Mediated Airway Smooth Muscle Contraction
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Penile Detumescense Augmentation Mechanisms
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Penile Erection Impairment
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Noradrenaline/Gs Expression Targets
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Epinephrine/Gs Expression Targets
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Acetylcholine Expression Targets
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Dopamine/Gi Expression Targets
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CXCL6 Expression Targets
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CXCL1 Expression Targets
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CXCL2 Expression Targets
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CXCL3 Expression Targets
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CXCL5 Expression Targets
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Complement Component GPCRs Signaling
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Clozapine Induced Granulocytopenia
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Erythropoietin -> NF-kB Expression Targets
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Erythropoietin -> ELK/SRF Expression Targets
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FPR1 -> Cytoskeleton Signaling
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FSHR Expression Targets
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Glutamate/Gq Expression Targets
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EGFR Transactivation in Cancer and Non-Cancer Cells
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IGF2 -> HIF1A/MYC Expression Targets
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IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
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Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
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IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
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Thromboxane A2 Expression Targets
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LPA Expression Targets
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Dronabinol/Anandamide Expression Targets
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S1P Expression Targets
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MTNR1 Signaling
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EDN1 Expression Targets
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NPY Expression Targets
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EDN3 Expression Targets
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Lysophosphatidic Acid/LPARs Signaling
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Ras-GRF Regulation Signaling
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PI3K/RAC1 Signaling
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IL1B -> PGE2 Expression Targets
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ace2
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Model of PPARG signaling in psoriasis
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Model of PPARG related pathways in psoriasis (short version)
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1_Formation of cysts in polycystic kidney disease
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1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
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2_Cardiomyocyte hypertrophy
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2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
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2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
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4_1_Airway smooth muscle cells contraction
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1_2_Insulin synthesis and secretion: insulin secretion
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1_1_Insulin synthesis and secretion: insulin processing and storage
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1_Decreased secretion of thyroid hormones
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Model of PPARG signaling in psoriais (tested)
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