Protein NFKBIA

URN urn:agi-llid:4792
Total Entities 0
Connectivity 3982
Name NFKBIA
Description nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Notes This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Primary Cell Localization Cytoplasm
Class Transcription factor
ObjectType Protein

Pathway Osteoarthritis
MTHFR Activity Regulation
Dopamine Receptors Signaling
Cortisol in Resolving Inflammation
Toll-like Receptors Act through MYD88-TIRAP Signaling
Toll-like Receptors Act through MYD88 Signaling
Dectin-1 (CLEC7A) Signaling
DC-SIGN (CD209) Signaling
TLR4 Signaling in Leukocytes
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
V(D)J Recombination Activation
Immunoglobulin Class-Switch Recombination Activation
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Proplatelet Maturation
Bradykinin Effects in Inflammation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
MC1R in anti-Inflammatory Signaling
Prostaglandin E2 Receptor Signaling in Neurons
Leukotriene Effect on Vascular Endothelial Cell Response
Eicosanoids in Myeloid Cell Activation
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Neutrophil Activation via Adherence on Endothelial Cells
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by NO
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
Nociception Expression Targets Signaling
BDKRB1/2 -> Interleukins Production
DRD2 -> TRPC1 Transcription
TACR1 -> TNF/IL6/IL8 Production
IL1B Expression Targets -> Nociception
SCF/BTRC Complex
SCF/FBXO7 Complex
Proteins Involved in Atherosclerosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Myocardial Remodeling
Myocardial Infarction
MAVS in Antiviral Innate Immune Response in Myocarditis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
NO Synthesis in Early Vasospasm
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Acute Phase in Atopic Dermatitis
Atopic Dermatitis
IL17 Signaling in Psoriasis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th17-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
AGE Related Insulin Resistance in Skeletal Muscles
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
RET1 Mutation in Hyperparathyroidism
Bone Remodeling in Hyperthyroidism
Thymic Follicular Hyperplasia
Fatty Acids in Hypertension and Atherosclerosis Development
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
Enterocyte Mediated Mucosal Damage in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
Metastatic Colorectal Cancer
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
OipA Signaling in Helicobacter Pylori Infection
Proteins Involved in Helicobacter Infections
CagA Phosphorylation Independent Signaling
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Splenic Marginal Zone Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
Osteoclast Activation in Multiple Myeloma
Multiple Myeloma
Antiphospholipid Antibodies and Endothelial Cell Interaction
T-Cell Acute Lymphoblastic Leukemia
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
IL33 Signaling Related Eosinophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
Antigen-Presenting Cell Role in Asthma
B-Cell Mediated IgE Production in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
Hyper IgM Syndrome
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
IL1B Induced Arthralgia
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
Proteins Involved in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
Apoptosis Block in Infected Cells
CD4+ T-Cell Death in HIV
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
NF-kB Signaling Activation in Huntington Disease
Gluten Impact on Neuronal System (Hypothesis)
IL6 Promotes Inflammation in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
Osteoclasts Function in Osteopetrosis
Osteoclast Activation in Postmenopause
Genes with Mutations Associated with Psoriatic Arthritis
Microglia Activation in Alzheimer's Disease
HMGB1 and IL1B in Neuroinflammation
Proteins Involved in Glioblastoma
Vascular Endothelial Cell Vasodilation in Brain
Postsynaptic Neuron Activation
nNOS (NOS1) and iNOS (NOS2) Activation via Glutamate
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Microglia Activation in Parkinson's Disease
Glutamate Role in Parkinson's Disease
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
MIR155 Role in Th17-Cell in Multiple Sclerosis
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
Proteins Involved in Breast Cancer Related to NOTCH Signaling Pathway
Breast Cancer
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
MIF Role in Cholesteatoma
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
TLR3 Role in Retinal Pigment Epithelial Cell
EPHA2 Mutations in Cataract
OPTN Effects on NF-kB Signaling in Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Cytokines Trigger Otitis Media
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
Ammonia Effects on Brain Cells
CD157/ITGB2 Signaling in Myeloid Cell
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100B Expression Targets
Dopamine/Gi Expression Targets
B-Cell Receptor -> NF-kB Signaling
TGFBR3 -> ARRB2 Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
gamma Globulins Expression Targets
CD22 -> NF-kB Expression Targets
CD19/CR2 Expression Targets
CD72 -> STAT Expression Target
CD8 -> STAT Expression Targets
CD80 -> STAT Expression Targets
CD86 -> STAT Expression Targets
CSF2 -> NF-kB Expression Targets
Doxorubicin Induced Cardiotoxicity
Clozapine Induced Granulocytopenia
Cyclosporine Induced Nephrotoxicity
EGF -> CTNN Expression Targets
Erythropoietin -> NF-kB Expression Targets
PECAM1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> STAT1/NF-kB Expression Targets
EGFR -> Expression Targets in Colon
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
NFKB Signaling Activation by Blocking of Tumor Suppressors
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
Genes with Mutations in Cancer-Associated Resisting to Cell Death
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Telomeric Proteins/NFKB Positive Feedback Interplay in Cancer
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
Lactate as a Signaling Molecule in Cancer Cells
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
CD19 -> NF-kB Signaling
AGER -> NF-kB Signaling
FibronectinR -> NF-kB Signaling
MacrophageR -> CEBPB -> NF-kB Signaling
Fibronectin Expression Targets
ICAM1 Expression Targets
Fibrinogen Expression Targets
EGFR -> Expression Targets in Skin
IFNLR1-> STAT/NFKB Signaling
IL7R -> FOXO/NF-kB Signaling
IL15R -> NF-kB/NFATC Signaling
IL23R -> STAT3/NF-kB Signaling
IL1R -> NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL7 Expression Targets
IL15 Expression Targets
IL12B Expression Targets
IL16 -> NF-kB Expression Targets
PAF/Gq -> NF-kB Expression Targets
CD40 -> Expression Targets in Lymph Node
Elevated Receptors -> Expression Targets in Spleen
NCAM1 -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NOTCH -> NF-kB Signaling
DLL4 Expression Targets
ADAM17 Expression Targets
JAG1 Expression Targets
DLL1 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> NF-kB Expression Targets
DDR1 -> NF-kB Signaling
Collagen -> NF-kB Expression Targets
TNF-alpha/TNFRSF1A Signaling
TNF-alpha/TNFRSF1B Signaling
NF-kB Canonical Signaling
TCR -> NF-kB Expression Targets
T-Cell Receptor -> NF-kB Signaling
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
EDA Expression Targets
EctodysplasinR -> NF-kB Signaling
NGFR -> NF-kB Signaling
TNFR -> NF-kB Signaling
TLR3 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR4/5/7/9 -> NF-kB Signaling
TLR1/2/6 -> NF-kB Signaling
TLR3 -> NF-kB Signaling
ROS in Triggering Vascular Inflammation
Glutamate Mediated Neurotoxicity
Ca2+ Cytosolic Overload
pathway 4
cypa
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of infarct size
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of lethality
Neighbors of tumor regression
Neighbors of body weight
Neighbors of microvessel density
Neighbors of radioresistance
Neighbors of shear stress
Neighbors of viral load
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of blood glucose
Neighbors of radiosensitivity
Neighbors of cell permeability
Neighbors of gastric cancer risk
Neighbors of infarct area
Neighbors of lymphocyte count
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of infarct size
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of lethality
Neighbors of tumor regression
Neighbors of body weight
Neighbors of microvessel density
Neighbors of radioresistance
Neighbors of shear stress
Neighbors of viral load
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of blood glucose
Neighbors of radiosensitivity
Neighbors of cell permeability
Neighbors of gastric cancer risk
Neighbors of infarct area
Neighbors of lymphocyte count
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of SMC proliferation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of cell migration
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of immune system function
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of hepatocyte proliferation
Neighbors of neuroprotection
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of first trimester pregnancy
Neighbors of sensitization
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of life span
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of injury
Neighbors of atherogenesis
Neighbors of carcinogenesis
Neighbors of inflammation
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of insulin resistance
Neighbors of infection
Neighbors of preeclampsia
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of colorectal cancer
Neighbors of ischemia
Neighbors of melanoma
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of neoplasm
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of myocardial fibrosis
Neighbors of prostate cancer
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of macrophage
Neighbors of intestine epithelium cell
Neighbors of neutrophil
Neighbors of lung
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of heart
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of Ras GTPase
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of beta adrenoceptor
Neighbors of IKBK
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of PDGF-BB
Neighbors of IL12
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of TSH
Neighbors of endothelin
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of histone H3
Neighbors of SAPK
Neighbors of PP2B
Neighbors of CD3 complex
Neighbors of relaxin
Neighbors of PDGF receptor
Neighbors of caspase
Neighbors of TNF-alpha receptor
sars-cov no binding
BCL6-TP53-BCL2
dsRNA induces innate immunity and INFs in alveolar cells
Innate immunity in Leukocytes
Dendritic Cell Activation in COVID19
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Osteoclast functional impairment in osteopetrosis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Autophagy dysfunction in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
2_HIV - induced depletion of CD4+ T-cells
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
1_Microangiopathy in diabetic neuropathy
2_Neuron and Schwann cell death
1_Glutamate and calcium excitotoxicity of motor neurons in ALS
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
drug-target pairs direct regulation
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Ageing (Mammalian Animal Model)
Genes with Mutations Associated with Hodgkin Lymphoma
Genes with Mutations Associated with Psoriatic Arthritis
Genes with Mutations Associated with Glioma
other partners for SARS

Source Biopax
curated
ResNet
GO component

MedScan ID 4792

LocusLink ID 4792
18035
25493
104829
282291
323099

Alias RL/IF-1
IkBalpha
Nuclear factor of kappa light chain gene enhancer in B-cells
major histocompatibility complex enhance-binding protein MAD3
MAD-3
Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
P-I-kappaB-alpha
nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
IKBA_HUMAN
IkappaBalpha
NF-kappaB inhibitor alpha
NFKBIA
IKBA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibito
IkappaB/MAD3
Inhibitor of 3000097
AI462015
nuclear factor kappaB inhibitor alpha
MAD-III
nuclear factor of kappa light polyp gene enhancer in B-cell I
NFKB inhibitor alpha
Major histocompatibility complex enhancer- binding protein MAD3
I(Kappa)B(alpha)
RL/IF I
MAD-3/I kappa B alpha
NFKBI
nuclear factor of kappa light chain gene enhancer in b-cells inhibitor
IkappaB-alpha/MAD3
nuclear factor of kappa light polyp gene enhancer in B-cell 1
EDAID2
I-kappa-B-alpha
ikB-alpha
major histocompatibility complex enhancer-binding protein MAD3
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NF-kappa-B inhibitor alpha
I-kappaBalpha
Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha
Ikappa-Balpha
RL/IF-1s
lkappa-Balpha
expressed sequence AI462015
RL/IF Is
I-kappaB-alpha
MAD III
MGC56666
NF-kappaB inhibitor alpha-like protein B
alpha b
chromosome
fb81f08
ikbaB
nfkbiab
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
scaffold
wu:fb81f08
zgc:56666
zgc:77616

GO ID 0051059
0019899
0008139
0008134
0031625
0007249
0006915
0070417
0007253
0042994
0070498
0031663
0043392
0032088
0045746
0043066
0010888
0010745
0045638
0070427
0070431
0032270
0010875
0050729
0045944
0016579
0006606
1901222
0042127
0043330
0032495
0035994
0034142
0033209
0016032
0033256
0005737
0005829
0005654
0005634
0005886
0031072
0044877
0071345
0071407
0071356
0045893
0010468
0032496
0032991
0097421
0005622
0032403
0045087
0034146
0006916
0071216
0032481
0002756
0002755
0000060
0005515
0034134
0034138
0035666
0008063
0034130
0051092
0038095
0043234
0042345
0048011
0034166
0050852
0038123
0038124
0034162
0019048
0042802
0002224
0002223
0044419
0010552
0045833
0032376
0009618
0009617
0045941
0003719

KEGG ID hsa:4792
mmu:18035
rno:25493

MedLine Reference 12200125
12700242
12897149
14764603
15308505
16081881
16135962
16938483
1741294
10195896
10199915
10349636
10702415
10922068
11042159
11067893
11076861
11130978
11133232
11217851
11221845
11241200
11799106
11880364
11913973
12083419
12167702
12397017
12424381
12466851
12477932
12589049
12843402
12896983
12920239
12938156
1339305
14585967
14665694
14741691
14763901
14764534
14767066
14960276
14966265
14978074
14991073
15020231
15102471
15251865
15294950
15317747
15536134
15618518
15671248
15714207
15811852
15820254
15845452
15879100
15923614
15998793
16141072
16141073
16166517
16199483
16231352
16260626
16371367
16452166
16481354
16737960
16804897
16931600
1740450
7552992
7590249
7603567
7867065
7936653
7963540
8628301
8642348
8662753
8858144
8864120
8887559
8914937
9186501
9597130
9743524
9854797
10026139
10085062
10102628
10329681
10393859
10398585
10421793
10480634
10521480
10580107
10582246
10635328
10637284
10644755
10655476
10657303
10723127
10747850
10783893
10848576
10869418
10928981
10969074
11042193
11095741
11106428
11278695
11287411
11313474
11493922
11511100
11696595
11809792
11983170
12028809
12084717
12086926
12193729
12244195
12297126
12377412
12388747
12419806
12429743
12433922
12518988
12620896
12651903
12704657
12711606
12748192
12921778
12944982
12972430
12973300
13680285
1427874
14523047
14561767
14576361
14623898
14685242
14743216
1493333
15068390
15073126
15125834
15161102
15173174
15184376
15202778
15247916
15330761
15337789
15389589
15389633
15613239
15671028
15979856
16046415
16105840
16189514
16258173
16407234
16426569
16756995
16919536
16955245
17003112
17062574
17148610
1829648
3140380
7479976
7565415
7679069
7700645
7739562
7878004
8601309
8615004
8622692
8709193
8797825
8940099
9060679
9214631
9244310
9252186
9334723
9372968
9409737
9452483
9566883
9721103
9734360
9738011
9792645
9859996
9865694
9873017
9882613
9892650
9990853
12459277
12711254
15310755
15169890
16051172
16109975
10882136
15489334
16540234
17284228
17307728
17316064
17318773
17351338
17354114
17463416
17701919
8657102
9865693
12872135
17098744
17202411
17237376
17273479
17310217
17392377
17486138
17692539
1588976
15946255
16875840
16928772

CellType cells in white pulp
glandular cells
Hepatocytes
squamous epithelial cells
respiratory epithelial cells
trophoblastic cells
Macrophages
cells in granular layer
Pneumocytes
cells in molecular layer
cells in seminiferus ducts
germinal center cells
myocytes
Purkinje Cells
Leydig Cells
non-germinal center cells
glial cells
neuronal cells
cells in glomeruli
follicle cells
cells in tubules
lymphoid tissue
urothelial cells
hematopoietic cells
cells in endometrial stroma
epidermal cells
ovarian stroma cells
smooth muscle cells
exocrine glandular cells
cells in red pulp
islets of Langerhans
bile duct cells
hepatocyte
squamous cell
airway epithelial cell
trophoblast
macrophage
pneumocyte
germinal center B-cell
muscle cell
Purkinje cell
Leydig cell
neuroglia
neuron
ovary follicle cell
kidney tubule cell
transitional epithelial cell
hematopoietic cell
endometrial stromal cell
epidermis cell
smooth muscle myocyte
exocrine cell

Tissue spleen
parathyroid gland
Liver
esophagus
bronchus
stomach, lower
Placenta
Lung
fallopian tube
Cerebellum
stomach, upper
Prostate
gall bladder
testis
rectum
lymph node
heart muscle
Salivary gland
hippocampus
cerebral cortex
thyroid gland
seminal vesicle
nasopharynx
tonsil
skeletal muscle
oral mucosa
Kidney
cervix, uterine
Adrenal gland
Ovary
Appendix
lateral ventricle
colon
urinary bladder
duodenum
bone marrow
uterus, post-menopause
breast
uterus, pre-menopause
Skin
vagina
small intestine
vulva/anal skin
smooth muscle
Pancreas
epididymis
myocardium
skeletal muscles
mouth mucosa
lymphoid tissue

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio
Human

Mouse chromosome position 12
12 C1-C3

OMIM ID 164008
612132
OMIM:164008

Rat chromosome position 6q23

Hugo ID 7797
HGNC:7797

Human chromosome position 14q13.2
14q13

Swiss-Prot Accession P25963
P25963.1
Q9Z1E3
Q9Z1E3.2
Q63746
Q63746.1
B2R8L6
Q3U9W9
Q3UB40
Q80ZX5
B2RYS5
Q9UGJ5
IKBA_HUMAN
IKBA_MOUSE
IKBA_RAT
B2R8L6_HUMAN
B2RYS5_RAT
Q3UB40_MOUSE

PIR ID A39935
A44437

GenBank ID NC_000014
NM_020529
NP_065390
NG_007571
AJ249283
AJ249284
AJ249285
AJ249286
AJ249287
CAB65110
AJ249288
CAB65111
AJ249289
CAB65112
AJ249290
CAB65113
AJ249291
CAB65114
AJ249294
CAB65556
AJ249295
AL133163
AY496422
AAR29599
CH471078
EAW65875
CS542431
CAM91165
HI574170
CBX47574
KT584919
S67380
AAD14949
U08468
AK311515
AK313421
BAG36213
AY033600
AAK51149
BC002601
AAH02601
BC004983
AAH04983
BT007091
AAP35754
BU737609
M69043
AAA16489
P25963
NC_000078
NM_010907
NP_035037
AC158398
CH466526
EDL36726
U57524
AAD10341
AI462015
AK089215
AK151115
BAE30124
AK151608
BAE30547
AK161622
BC046754
AAH46754
CF379853
U36277
AAA79696
Q9Z1E3
NC_005105
NM_001105720
NP_001099190
AC_000074
AABR07064338
AAHX01044232
AAHX01044233
CH473947
EDM03427
EDM03428
BC166886
AAI66886
BF417507
CA509173
CB316505
CB324027
CB793714
FQ214065
FQ215246
FQ225350
FQ225877
FQ226288
FQ227283
FQ233200
FQ233557
FQ233627
FQ234138
FQ234262
X63594
CAA45138
Q63746
ABBA01061503
AAHY01100242
AAHY01100243
AC_000146
AC_000034
NC_018925
AMYH02029008
AABR06044120
AABR06044119
NT_026437
NW_001838110
NW_925539
AC_000057
CR589981
CR591996
CR592525
CR593002
CR594547
CR595601
CR596344
CR600730
CR603242
CR604111
CR606719
CR610344
CR610623
CR612243
CR613814
CR615977
CR617669
CR618438
CR621120
CR623392
CR626144
Q9UGJ5
NT_039551
NW_001030500
Q3U9W9
Q3UB40
NW_001084845
NW_047760
XM_343065
XP_343066
XM_001075778
XP_001075778
BG078274
NW_000053
BG064981
14548069
57674
1022734
123787735
123791056
28386026
4097335
61226507
74185295
74195979
119586279
126682
12803543
13436416
14029101
187291
30583021
39654021
6688192
6706211
74753317
NT_086806
17221416
75066005
86823904
AAI05485
AJ420928
BC105484
CAD12786
NC_007319
NM_001045868
NP_001039333
NW_001494046
Q8WNW7
29476855
37725734
38382969
82201956
82209677
AAH50175
AAH62524
AAO26406
AI545462
AI584648
AY163841
BC050175
BC062524
BX649530
NC_007128
NM_199629
NP_955923
NW_001511519
Q6K195
Q7ZW68
148704779
149051254
149051255
XM_234230
XP_234230
NW_043949
NT_037845.1
54261748
126007125
49659397
54261749
323099
BC050175,BC062524
Dr.77409
ZDB-GENE-030131-1819
dre:323099

Swiss-Prot ID IKBA_HUMAN
IKBA_MOUSE
IKBA_RAT
Q3UB40_MOUSE
B2RYS5_RAT
B2R8L6_HUMAN

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000100906
ENSP00000216797.5
ENST00000216797.9
ENSMUSG00000021025
ENSMUSP00000021413.7
ENSMUST00000021413.8
ENSRNOG00000007390
ENSRNOP00000009894.5
ENSRNOT00000009894.6
ENSMUST00000021413
ENSRNOT00000009894
ENSRNOP00000009894
ENSMUSP00000021413
ENSP00000216797
ENST00000216797

MGI ID MGI:104741
104741
2144835

RGD ID 3171

Unigene ID Hs.81328
Mm.170515
Rn.12550
Bt.9027
Dr.77409
Rn.104476

Homologene ID 7863

Shape O-vertex

IPI ID IPI00211841
IPI00331017
IPI00018330

Proteome Biochemical Function Inhibitor or repressor

Microarray ID 101554_at
104149_at
X63594cds_at
X63594cds_g_at
A_42_P544487
206329_Rn
Msa.1690.0_at
Msa.1690.0_g_at
1448306_at
133630_r_at
1438157_s_at
167965_f_at
A_65_P03979
H3026A08-3
A_51_P295192
NM_010907
201502_s_at
231699_at
1461_at
M69043_at
A_23_P106002
I_959455
A_14_P120088
A_14_P114684
A_14_P133399
1420088_at
1449731_s_at

Homo sapiens Chromosome position 14q13

Ensembl Transcript ID ENST00000216797

FunctionalClass NF-kappaB binding
heat shock protein binding
nuclear localization sequence binding
protein binding
ubiquitin protein ligase binding
transcription factor binding

Bos taurus Chromosome position 21

Mus musculus Chromosome position 12 C1-C3
12

Proteome Subcellular Localization Cytoplasmic

Compartment cytoplasm
DNA
void

KEGG pathway Adipocytokine signaling pathway
Apoptosis
B cell receptor signaling pathway
Chronic myeloid leukemia
Small cell lung cancer
T cell receptor signaling pathway
Toll-like receptor signaling pathway

RefSeq ACCNUM NP_065390

Rattus norvegicus Chromosome position 6q23

Ensembl Gene ID ENSG00000100906
LRG_89

Keyword cytoplasm
ubiquitin
nucleus
DNA
binding activity
kinetochore

LocatorString pmquery:curcumin+prostate+cancer
pmquery:curcumin prostate cancer

Proteome Organismal Role Cell death/Apoptosis
Anti-pathogen response