Pathway
|
Osteoarthritis
|
|
MTHFR Activity Regulation
|
|
Melatonin Effects on Circadian Cycle
|
|
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
|
|
Dopamine Receptors Signaling
|
|
Cortisol in Resolving Inflammation
|
|
Testicular AMH Production
|
|
Toll-like Receptors Act through MYD88-TIRAP Signaling
|
|
NOD-like Receptors
|
|
Toll-like Receptors Act through MYD88 Signaling
|
|
TLR4 Signaling in Leukocytes
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Independent B-Cell Activation
|
|
V(D)J Recombination Activation
|
|
Immunoglobulin Class-Switch Recombination Activation
|
|
Natural Killer Cell Activation through ITAM-Containing Receptors
|
|
Natural Killer Cell Activation through ITSM-Containing Receptors
|
|
Natural Killer Cell Activation
|
|
Peripheral T-Cell Tolerance
|
|
T-Cell Central Tolerance
|
|
CD8+ T-Cell Activation
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
|
|
AHR Signaling in Treg and Dendritic Cells Function
|
|
Th17-Cell Differentiation
|
|
AHR Signaling in Tr1 Cells Function
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Plasmin Effects in Inflammation
|
|
Proplatelet Maturation
|
|
Bradykinin Effects in Inflammation
|
|
Toll-like Receptors in Sterile Inflammation
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
Necrosis
|
|
Lipoxin A4/FPR2-Related Neutrophil Depression
|
|
MC1R in anti-Inflammatory Signaling
|
|
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
|
|
Prostaglandin E2 Receptor Signaling in Neurons
|
|
Leukotriene Effect on Vascular Endothelial Cell Response
|
|
Eicosanoids in Myeloid Cell Activation
|
|
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Eosinophil Activation
|
|
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cell Activation without Degranulation
|
|
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
|
|
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
|
|
Macrophage Related Iron Uptake and Release
|
|
Macrophage M1 Lineage
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
AHR Signaling in M1 Macrophages Function
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
|
|
Neutrophil Recruitment and Priming
|
|
Neutrophil Activation via Adherence on Endothelial Cells
|
|
Negative Acute Phase Proteins Synthesis
|
|
Positive Acute Phase Proteins Synthesis
|
|
Vascular Endothelial Cell Activation by NO
|
|
Vascular Endothelial Cell Activation by Cytokines
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Vascular Endothelial Cell Permeability Activation
|
|
Adipokines Production by Adipocyte
|
|
Lipolysis Regulation in Adipocyte
|
|
Nociception Expression Targets Signaling
|
|
BDKRB1/2 -> Interleukins Production
|
|
DRD2 -> TRPC1 Transcription
|
|
TACR1 -> TNF/IL6/IL8 Production
|
|
IL1B Expression Targets -> Nociception
|
|
Melatonin in Cell Survival and Antioxidant Response
|
|
Apoptosis
|
|
SCF/FBXW7 Complex
|
|
Cardiomyocyte Dysfunction
|
|
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
|
|
Dendritic Cells Function in Atherosclerosis
|
|
RAGE/AGER and S100 Proteins in Cardiovascular Injury
|
|
Low-Density Lipoproteins and Chemokines in Atherosclerosis
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Dilated Cardiomyopathy
|
|
Proteins Involved in Hypertrophic Cardiomyopathy
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Proteins Involved in Hypoxia-Induced Pulmonary Hypertension
|
|
Endothelial Cell Dysfunction in Pulmonary Hypertension
|
|
Myocardial Remodeling
|
|
Myocardial Infarction
|
|
MAVS in Antiviral Innate Immune Response in Myocarditis
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
NO Synthesis in Early Vasospasm
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Keratinocyte Proliferation in Acne Vulgaris
|
|
Telogen Maintenance in Androgenic Alopecia
|
|
Atopic Dermatitis Onset
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
Acute Phase in Atopic Dermatitis
|
|
Atopic Dermatitis
|
|
Melanoma
|
|
MITF as a Regulator of Melanoma Cell Development
|
|
IL17 Signaling in Psoriasis
|
|
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
|
|
Dendritic Cells Function in Psoriasis
|
|
Melanocyte Role in Skin Aging
|
|
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
|
|
Dendritic Cell Activation in Systemic Lupus Erythematosis
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
Th17-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Toll-like Receptors in beta-Cell
|
|
Macrophage Function in Diabetes Mellitus Type 1
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
|
|
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
|
|
Protein Kinase C in Diabetic Microangiopathy
|
|
Peripheral Tissue Microangiopathy
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Podocyte Dysfunction in Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
|
|
Microangiopathy in Diabetic Neuropathy
|
|
Proliferative Diabetic Retinopathy
|
|
AGE Related Insulin Resistance in Skeletal Muscles
|
|
Adipose Tissue Inflammation Provokes Insulin Resistance
|
|
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
|
|
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Recovery in Diabetes Mellitus
|
|
beta-Cell Destruction in Diabetes Mellitus Type 1
|
|
Nitric Oxide Effects on beta-Cell
|
|
Immune Sustem Activation in Hashimoto's Thyroiditis
|
|
Hashimoto's Thyroiditis
|
|
RET1 Mutation in Hyperparathyroidism
|
|
Bone Remodeling in Hyperthyroidism
|
|
Immune System Activation in Hyperthyroidism
|
|
Thymic Follicular Hyperplasia
|
|
Fatty Acids in Hypertension and Atherosclerosis Development
|
|
Adipokines Production by Adipocyte Impaired in Obesity
|
|
Proteins Involved in Obesity
|
|
CD4+T-Cell Response in Celiac Disease
|
|
Metastatic Colorectal Cancer
|
|
Crohn's Disease
|
|
Paneth-Cell Function in Crohn's Disease
|
|
Macrophage Dysfunction
|
|
Dendritic Cell Dysfunction in Crohn's disease
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
CagA Phosphorylation Independent Signaling
|
|
Dendritic Cell Function in Ulcerative Colitis
|
|
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
|
|
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
|
|
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
Proteins Involved in Acute Myeloid Leukemia
|
|
Apoptosis Block in Acute Myeloid Leukemia Cell
|
|
Acute Myeloid Leukemia
|
|
Antiphospholipid Antibodies in Endothelial Cell
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Proteins Involved in Chronic Myeloid Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Diffuse Large-B-Cell Lymphoma ABC Subtype
|
|
Proteins Involved in Diffuse Large-B-Cell Lymphoma
|
|
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
|
|
Follicular Lymphoma
|
|
Hodgkin and Reed-Sternberg Cells in Hodgkin Lymphoma
|
|
Proteins Involved in Hodgkin Lymphoma
|
|
Hodgkin Lymphoma
|
|
Proteins Involved in Mantle Cell Lymphoma
|
|
Mantle Cell Lymphoma
|
|
Apoptosis of Mantle Cell Deregulation
|
|
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
|
|
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
|
|
Splenic Marginal Zone Lymphoma
|
|
Proteins Involved in Marginal Zone Lymphoma
|
|
Osteoclast Activation in Multiple Myeloma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
Proteins Involved in Multiple Myeloma
|
|
Antiphospholipid Antibodies and Endothelial Cell Interaction
|
|
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
SERPINA1 Associated Liver Damage
|
|
Eosinophil Survival in Asthma
|
|
Il17 Signaling Related Neutrophilia in Asthma
|
|
IL33 Signaling Related Eosinophilia in Asthma
|
|
TSLP Signaling in Bronchial Epithelial Cell in Asthma
|
|
IL17F Signaling in Bronchial Epithelial Cell in Asthma
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Goblet-Cell Related Mucus Secretion in Asthma
|
|
Club-Cell Role in Asthma
|
|
Neutrophil Degranulation via FPR1/IL8
|
|
Basophil Activation in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Mast-Cell Related Chemokines Signaling in Asthma
|
|
Antigen-Presenting Cell Role in Asthma
|
|
B-Cell Mediated IgE Production in Asthma
|
|
Th17-Cell Differentiation in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
|
|
Airway Epithelial Cell Dysfunction
|
|
CFTR Expression in Epithelial Cells (Class I Mutations)
|
|
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
|
|
Osteoclast Activation in Gout
|
|
Neutrophil Recruitment in Sinovium in Gout
|
|
Monocytes Function in Gout
|
|
Hyper IgM Syndrome
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
Apoptosis of Chondrocyte
|
|
IL1B Induced Arthralgia
|
|
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
|
|
Synovial Fibroblast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
|
|
Apoptosis Block in Synovial Fibroblast
|
|
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
|
|
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
CD4+ T-Cell Function Decline in HIV
|
|
Apoptosis Block in Infected Cells
|
|
CD4+ T-Cell Death in HIV
|
|
Toll-like Receptors (TLR) in Periodontitis
|
|
Diabetes Induced Periodontitis
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
PAPA Syndrome
|
|
TNF Receptor Associated Periodic Syndrome
|
|
Mevalonate Kinase Deficiency
|
|
Blau Syndrome
|
|
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
|
|
Cryopyrin (NLPR3) Associated Periodic Syndromes
|
|
Familial Cold Autoinflammatory Syndrome 2
|
|
Familial Mediterranean Fever
|
|
Majeed Syndrome
|
|
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
|
|
NF-kB Signaling Activation in Huntington Disease
|
|
Proteins Involved in Huntington Disease
|
|
IL6 Promotes Inflammation in Muscular Dystrophies
|
|
IL6 Overexpression After Contraction in Skeletal Muscles in Muscular Dystrophies
|
|
Ca2+ Overload in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
|
|
Osteoclasts Function in Osteopetrosis
|
|
Osteoclast Activation in Postmenopause
|
|
Microglia Activation in Alzheimer's Disease
|
|
Proteins Involved in Epilepsy
|
|
Ketogenic Diet Mechanism (Hypothesis)
|
|
Blood-Brain Barrier Disruption in Epileptiform Disorders
|
|
HMGB1 and IL1B in Neuroinflammation
|
|
Glioblastoma, Primary
|
|
Proteins Involved in Glioblastoma
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Proteins Involved in Astrocytoma
|
|
Proteins Involved in Glioma
|
|
Vascular Endothelial Cell Vasodilation in Brain
|
|
Postsynaptic Neuron Activation
|
|
nNOS (NOS1) and iNOS (NOS2) Activation via Glutamate
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
Microglia Activation in Parkinson's Disease
|
|
Glutamate Role in Parkinson's Disease
|
|
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
|
|
Microglia and Motor Neuron Interaction Dysregulation
|
|
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
|
|
MIR155 Role in Th17-Cell in Multiple Sclerosis
|
|
Breast Cancer
|
|
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
|
|
Dioxin Role in Endometriosis
|
|
MIF Role in Cholesteatoma
|
|
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
|
|
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV Infection and Cancer
|
|
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
|
|
Androgen Receptor/FKBP5 Signaling
|
|
Prostate Cancer
|
|
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
|
|
TLR3 Role in Retinal Pigment Epithelial Cell
|
|
ER Stress in Macular Degeneration
|
|
EPHA2 Mutations in Cataract
|
|
OPTN Effects on NF-kB Signaling in Glaucoma
|
|
Glutamate Mediated Excitotoxicity in Glaucoma
|
|
OPTN Associated Glaucoma
|
|
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
|
|
Proteins Involved in Hearing Loss
|
|
Cochlear Inflammation (Noise-Induced)
|
|
Cytokines Trigger Otitis Media
|
|
Immune System Role in Otitis Media
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Alveolar Macrophages Dysfunction in COPD
|
|
Proteins Involved in Chronic Obstructive Pulmonary Disease
|
|
CAV1 Dependent Senescence of Lung Fibroblasts
|
|
T-Cell Cytotoxic Activation
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
Proteins with Altered Expression in Cystic Fibrosis
|
|
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
|
|
Plasmin Role in Glomerulonephritis
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Podocyte Dysfunction in Glomerulonephritis
|
|
Endothelial Cell Dysfunction in Pyelonephritis
|
|
Cryptorchidism Molecular Mechanism (Hypothesis)
|
|
Sertoli Cells Dysfunction Causes Male Infertility
|
|
Ammonia Effects on Brain Cells
|
|
CD157/ITGB2 Signaling in Myeloid Cell
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
S100P Expression Target
|
|
HMGB1 Expression Targets
|
|
TTR Expression Targets
|
|
S100B Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
B-Cell Receptor -> NF-kB Signaling
|
|
TGFBR3 -> ARRB2 Signaling
|
|
TLR -> ARRB2/NF-kB Signaling
|
|
CD19 Expression Targets
|
|
CD81 -> AP-1 Expression Targets
|
|
gamma Globulins Expression Targets
|
|
CD22 -> NF-kB Expression Targets
|
|
CD19/CR2 Expression Targets
|
|
CD72 -> STAT Expression Target
|
|
CD8 -> STAT Expression Targets
|
|
CD80 -> STAT Expression Targets
|
|
CD86 -> STAT Expression Targets
|
|
CSF2 -> NF-kB Expression Targets
|
|
Complement Component GPCRs Signaling
|
|
Doxorubicin Induced Cardiotoxicity
|
|
Clozapine Induced Granulocytopenia
|
|
Cyclosporine Induced Nephrotoxicity
|
|
Cocaine Induced Hepatotoxicity
|
|
Erythropoietin -> NF-kB Expression Targets
|
|
PECAM1 Expression Targets
|
|
F2 -> STAT1/NF-kB Expression Targets
|
|
PLG -> STAT1/NF-kB Expression Targets
|
|
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
TAM Receptor Signaling Activation in Cancer
|
|
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
Integrins in Cancer Cell Motility, Invasion and Survival
|
|
Epithelial to Mesenchymal Transition in Cancer: Overview
|
|
Cancer Cells Inhibit Adipocyte Differentiation
|
|
Skeletal Muscle Wasting in Cancer Cachexia
|
|
Lipogenesis/Lipolysis Activation in Cancer Cells and Cancer-Associated Adipocytes
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
IDO1 in Cancer Immune Escape
|
|
Effector T-cell Inactivation in Cancer Immune Escape
|
|
CD46/CD55/CD59 Inhibit Complement Mediated Lysis of Cancer Cells
|
|
DNMT and MBD Families Activation in DNA Methylation in Cancer
|
|
CD19 -> NF-kB Signaling
|
|
AGER -> NF-kB Signaling
|
|
FibronectinR -> NF-kB Signaling
|
|
MacrophageR -> CEBPB -> NF-kB Signaling
|
|
Fibronectin Expression Targets
|
|
ICAM1 Expression Targets
|
|
Fibrinogen Expression Targets
|
|
IFNLR1-> STAT/NFKB Signaling
|
|
IL7R -> FOXO/NF-kB Signaling
|
|
IL15R -> NF-kB/NFATC Signaling
|
|
IL23R -> STAT3/NF-kB Signaling
|
|
IL1R -> NF-kB Signaling
|
|
IL12R -> NF-kB/NFATC Signaling
|
|
IL7 Expression Targets
|
|
IL15 Expression Targets
|
|
IL12B Expression Targets
|
|
IL16 -> NF-kB Expression Targets
|
|
PAF/Gq -> NF-kB Expression Targets
|
|
MTNR1 Signaling
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
NOTCH -> NF-kB Signaling
|
|
DLL4 Expression Targets
|
|
ADAM17 Expression Targets
|
|
JAG1 Expression Targets
|
|
DLL1 Expression Targets
|
|
NOTCH Expression Targets
|
|
Adenosine Expression Targets
|
|
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
|
|
PDCD1 -> NF-kB Expression Targets
|
|
DDR1 -> NF-kB Signaling
|
|
Collagen -> NF-kB Expression Targets
|
|
TNF-alpha/TNFRSF1A Signaling
|
|
MERTK Signaling
|
|
TGF-beta Signaling
|
|
HIF1 Signaling
|
|
AMPK Signaling
|
|
BMPR2 Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
TNF-alpha/TNFRSF1B Signaling
|
|
KRAS Signaling
|
|
TCR -> NF-kB Expression Targets
|
|
T-Cell Receptor -> NF-kB Signaling
|
|
FASLG Expression Targets
|
|
TNF -> NF-kB Expression Targets
|
|
TNFSF10 Expression Targets
|
|
LTA Expression Targets
|
|
TNFSF14 Expression Targets
|
|
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
|
|
TNFSF13 Expression Targets
|
|
TNFSF13B Expression Targets
|
|
EDA Expression Targets
|
|
EctodysplasinR -> NF-kB Signaling
|
|
NGFR -> NF-kB Signaling
|
|
TNFR -> NF-kB Signaling
|
|
TLR3 Expression Targets
|
|
TLR5 Expression Targets
|
|
TLR7 Expression Targets
|
|
TLR1 -> 2/6 Expression Targets
|
|
IL1B Expression Targets
|
|
TLR4 -> NF-kB/IRF Expression Targets
|
|
IL1A Expression Targets
|
|
TLR9 Expression Targets
|
|
TLR4/5/7/9 -> NF-kB Signaling
|
|
TLR1/2/6 -> NF-kB Signaling
|
|
TLR3 -> NF-kB Signaling
|
|
ROS in Triggering Vascular Inflammation
|
|
ER Stress (Unfolded Protein Response)
|
|
Glutamate Mediated Neurotoxicity
|
|
Mitochondrial Damage Induced by Hypoxia
|
|
Ca2+ Cytosolic Overload
|
|
ace2
|
|
New Pathway (2)
|
|
cypa
|
|
PPAR Psoriasis
|
|
prarg negative regulators, ps-positive
|
|
prarg neg,ukn expres targets, ps-positive
|
|
Neighbors of NF-kB family
|
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Model of PPARG signaling in psoriasis
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PPARG negative regulators and targets
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Model of PPARG related pathways in psoriasis (short version)
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PPARs and neuroinflamation
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non-proteinal partners of SARSs
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BCL6-TP53-BCL2
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dsRNA induces innate immunity and INFs in alveolar cells
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Innate immunity in Leukocytes
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AGER feed forward loop in innate immunity
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Dendritic Cell Activation in COVID19
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1_Inflammation in keratinocytes in the pathology of acne
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2_Acute phase initiation in atopic dermatitis
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2_Interleukin-17 and interleukin-22 signaling in psoriasis
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1_The onset of atopic dermatitis
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1_TNF and IL1B provoke ECM degradation in osteoarthritis
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1_Osteoclast-mediated bone resorption in postmenopausal women
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2_Chondrocyte death in osteoarthritis
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2_The role of endothelial cells in pyelonephritis
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2_Podocyte dysfunction in glomerulonephritis
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3_Role of neurotrophic factor deprivation in retinal ganglion cell death
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2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
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3_Endoplasmic reticulum stress in age-related macular degeneration
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1_Low-density lipoprotein internalization and the accumulation of lipids in atherosclerosis
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2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
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1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
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2_Cardiomyocyte hypertrophy
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3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
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3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
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1_Th2 cell response in asthma
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3_2_Regulation of airway surface liquid (ASL) thickness
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3_1_Mucus accumulation in asthma
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2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
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4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
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4_Mucin hyperproduction in goblet and mucous cells in COPD
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2_Paneth cell dysfunction in Crohn's disease
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1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
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3_Autophagy dysfunction in Crohn's disease
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3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
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2_Intestine epithelial cells drive immunological responses in ulcerative colitis
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1_Intestine epithelial cell dysfunction in ulcerative colitis
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2_Lipotoxicity in NAFLD
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1_CD4+ T cell and epithelial cell response in celiac disease
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1_HIV entrance to the host cell and viral reproduction
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5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
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2_HIV - induced depletion of CD4+ T-cells
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3_1_HIV latency and low level of viral production
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3_2_HIV postintegration latency
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5_The rationale for the treatment of anemia of chronic disease with erythropoietin
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4_2_Insulin resistance: inflammation-related insulin resistance
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3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation
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4_3_Insulin resistance: FFA-related insulin resistance
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1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
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2_SERPINA1-associated liver damage
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1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
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3_Islet beta-cell destruction in T1D
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1_Microangiopathy in diabetic neuropathy
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2_Neuron and Schwann cell death
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1_Glutamate and calcium excitotoxicity of motor neurons in ALS
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1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
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Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
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Model of PPARG signaling in psoriais (tested)
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Interleukin-17 and interleukin-22 signaling in psoriasis
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