Functional Class Gb/g

URN urn:agi-aopfc:0000536
Total Entities 2
Connectivity 1499
Name Gb/g
Description G beta/gamma

ChildConcepts G-beta
G-gamma

Pathway Melatonin Effects on Circadian Cycle
High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
GCG and PPY Regulate Metabolism and Satiety
Ghrelin and Nesfatin-1 Regulate Stomach Functional State and Satiety
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Ghrelin and SST Regulate GH1 Release in Hypothalamus
Taste Receptors Activation in Tongue
L-cell: GCG, PYY and 5-HT Release
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
G-cell: Gastrin Secretion
N-cell: Neurotensin Production
Dopamine Receptors Signaling
Serotonin Receptors Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Leukotriene Effect on Vascular Endothelial Cell Response
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Histamine Receptor H3 Signaling in Neurons
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Basophil Activation
Eosinophil Activation
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Neutrophil Recruitment and Priming
Neutrophil Degranulation via FPR1 Signaling
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Vascular Endothelial Cell Activation by NO
Vascular Endothelial Cell Activation by Cytokines
Lipolysis Regulation in Adipocyte
Potassium Flux Regulation
Nociception Expression Targets Signaling
Sodium Flux Regulation
Vascular Motility
Ca2+ Flux Regulation
TAAR1 -> Neurotransmitter Uptake
NPY1R -> CRH/POMC Production
EDNRA/B -> Vascular Motility
ADORA1/2A -> Exocytosis
ADORA3 -> Mast-Cell Degranulation
ADRA2A -> Neurotransmitter Release
ADRB1 -> Prostaglandin Generation
BDKRB1/2 -> Vasodilation
BDKRB1/2 -> Ion Channels
BDKRB1/2 -> Prostaglandin Generation
BDKRB1/2 -> Interleukins Production
CNR1/2 -> Membrane Transport
CNR1/2 -> Vascular Motility
CNR1/2 -> IL1B/2/4/6/10 Production
DRD3 -> Dopamine Uptake
DRD2 Expression Targets
DRD1/3 -> Potassium Uptake
DRD2/4 -> Membrane Transport
GALR1/2/3 -> POMC/NPY Production
HRH1/2 -> Vascular Motility
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3/5 -> Ion Channels
CHRM1/2/3 -> Vascular Motility
OPRD/OPRM -> Ion Channels
OPRK -> Pain Perception
OPRL1 -> Ion Channels
PTGER2/3 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR2 -> Membrane Transport
HTR1 -> Membrane Transport
HTR1 -> Vascular Motility
TACR1 -> TNF/IL6/IL8 Production
GABA(B)R -> Postsynaptic Inhibition
GRM1/5 (Postsynaptic) -> Ion Channels
P2RY2/12/13/14 -> N-Type Calcium Channel
P2RY1/2/4/6 -> Potassium Channels
Melatonin in Cell Survival and Antioxidant Response
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Hypocretin (Orexin) in Arousal Regulation
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Endothelial Cell Dysfunction in Pulmonary Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Vascular Reactivity in Raynaud Disease
NO Synthesis in Early Vasospasm
Contraction Due Vasospasm
Melanoma
MITF as a Regulator of Melanoma Cell Development
Oxidative Stress in Vitiligo
Vitiligo
G-Proteins Signaling in Insulin Secretion in beta-Cell
Metastatic Colorectal Cancer
Antiphospholipid Antibodies in Platelets and Coagulation Cascade
Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
Eosinophil Activation and Degranulation in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
Airway Smooth Muscle Cell Contraction
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
Skin Fibrosis
ADK Expression Upregulation
CCL2 Role in CGRP Expression and Release
Vascular Smooth Muscle Cell Vasodilation in Brain
NO Effect on Vasodilation and Vasoconstriction
Hypocretin Elevation and Monoamine Oxidase Decrease/Inhibition
Sleep Disturbance (Hypothesis)
MIF Role in Cholesteatoma
Cholesteatoma
Prostate Cancer
Muscarinic Receptor-Mediated Airway Smooth Muscle Contraction
Penile Detumescense Augmentation Mechanisms
Penile Erection Impairment
Noradrenaline/Gs Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
Complement Component GPCRs Signaling
Clozapine Induced Granulocytopenia
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
FPR1 -> Cytoskeleton Signaling
FSHR Expression Targets
Glutamate/Gq Expression Targets
EGFR Transactivation in Cancer and Non-Cancer Cells
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
Thromboxane A2 Expression Targets
LPA Expression Targets
Dronabinol/Anandamide Expression Targets
S1P Expression Targets
MTNR1 Signaling
EDN1 Expression Targets
NPY Expression Targets
EDN3 Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
PI3K/RAC1 Signaling
IL1B -> PGE2 Expression Targets
ace2
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Formation of cysts in polycystic kidney disease
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
2_Cardiomyocyte hypertrophy
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
4_1_Airway smooth muscle cells contraction
1_2_Insulin synthesis and secretion: insulin secretion
1_1_Insulin synthesis and secretion: insulin processing and storage
1_Decreased secretion of thyroid hormones
Model of PPARG signaling in psoriais (tested)

MedScan ID 12100266

Alias Getagamma
G-protein beta/gamma-subunit complex
beta-gamma complexes
G(beta)(gamma) heterodimer
G-beta/G-gamma complexes
G-beta/G-gamma complex
G bg
G(beta)(gamma)
G-protein beta/gamma-subunit complexes
beta-gamma complex
Gb/g
G(beta)(gamma) heterodimers
G protein bg
heterotrimeric G-protein GTPase, gamma subunits
heterotrimeric G-protein GTPase, gamma subunit
heterotrimeric G-protein GTPase, beta subunit
heterotrimeric G-protein GTPase, beta subunits
G b/g
G protein b/g
G protein beta gamma
G protein beta/gamma

Cell Localization Cytoplasm