URN | urn:agi-llid:353376 |
---|---|
Total Entities | 0 |
Connectivity | 227 |
Name | TICAM2 |
Description | toll-like receptor adaptor molecule 2 |
Notes | TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004] |
Primary Cell Localization | Cytoplasm |
ObjectType | Protein |
Pathway | Cortisol in Resolving Inflammation |
---|---|
Antiviral Signaling through Pattern Recognition Receptors | |
TLR4 Signaling in Leukocytes | |
T-Cell Independent B-Cell Activation | |
Toll-like Receptors in Sterile Inflammation | |
Necrosis | |
MC1R in anti-Inflammatory Signaling | |
Macrophage M1 Lineage | |
CD16/CD14 Proinflammatory Monocyte Activation | |
AXL Receptor Inhibits Macrophages and Dendritic Cells Function | |
Dendritic Cells Function in Atherosclerosis | |
Myocardial Infarction | |
MAVS in Antiviral Innate Immune Response in Myocarditis | |
Toll-like Receptors (TLR) in Antiviral Innate Immune Response | |
Dendritic Cell Activation in Systemic Lupus Erythematosis | |
Crohn's Disease | |
Dendritic Cell Dysfunction in Crohn's disease | |
Dendritic Cell Function in Ulcerative Colitis | |
Nicotine anti-Inflammatory Effect in Ulcerative Colitis | |
Club-Cell Role in Asthma | |
Antigen-Presenting Cell Role in Asthma | |
Mucin Production in Goblet Airway Epithelial Cells | |
Airway Epithelial Cell Dysfunction | |
Monocytes Function in Gout | |
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis | |
Toll-like Receptors (TLR) in Periodontitis | |
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA) | |
PAPA Syndrome | |
TNF Receptor Associated Periodic Syndrome | |
Mevalonate Kinase Deficiency | |
Blau Syndrome | |
Cryopyrin (NLPR3) Associated Periodic Syndromes | |
Familial Cold Autoinflammatory Syndrome 2 | |
Familial Mediterranean Fever | |
Majeed Syndrome | |
HMGB1 and IL1B in Neuroinflammation | |
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes | |
Alveolar Macrophages Dysfunction in COPD | |
Mucin Hyperproduction in Goblet and Mucous Cells | |
TLR4 -> NF-kB/IRF Expression Targets | |
TLR4 -> IRF Signaling | |
pathway 4 | |
Model of PPARG signaling in psoriasis | |
Model of PPARG related pathways in psoriasis (short version) | |
sars-cov no binding | |
Dendritic Cell Activation in COVID19 | |
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media | |
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD | |
1_Th2 cell response in asthma | |
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease | |
2_Intestine epithelial cells drive immunological responses in ulcerative colitis | |
1_Intestine epithelial cell dysfunction in ulcerative colitis | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
2_Neuron and Schwann cell death | |
Model of PPARG signaling in psoriais (tested) |
Group | other partners for SARS |
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MedScan ID | 353376 |
---|
LocusLink ID | 353376 |
---|---|
225471 | |
364867 |
Alias | TIRAP3a |
---|---|
OTTHUMP00000162868 | |
toll-like receptor adaptor molecule II | |
Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2 | |
TRAM | |
TICAM2 | |
TIRP | |
TIR domain-containing adaptor molecule 2 | |
TIRAP3 | |
MGC129877 | |
TRIF-related adaptor molecule TRAM | |
MGC107370 | |
MGC129876 | |
TIRAP3a short | |
NF-kappa-B-activating protein 502 | |
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein | |
MyD88-4 | |
toll/interleukin-1 receptor domain-containing protein | |
TIR-containing adaptor molecule II | |
toll-like receptor adaptor protein 3 | |
OTTHUMP00000207407 | |
TRIF-related adaptor molecule | |
B430113A10 | |
toll-like receptor adaptor molecule 2 | |
TIR-containing adaptor molecule 2 | |
TICAM-2 | |
cytoplasmic adaptor | |
putative NF-kappa-B-activating protein 502 | |
toll/interleukin-1 receptor (TIR) domain-containing adapter protein | |
TIR domain-containing adapter molecule 2 | |
Trif | |
TIR domain-containing adapter protein | |
TRIF-related adapter molecule TRAM | |
TIR-containing adapter molecule II | |
TRIF-related adapter molecule | |
Toll-interleukin I receptor domain (TIR)-containing adapter molecule (TICAM) 2 | |
TIR-containing adapter molecule 2 | |
toll-like receptor adapter molecule 2 | |
toll-like receptor adapter molecule II |
GO ID | 0006888 |
---|---|
0007030 | |
0007249 | |
0002756 | |
0035669 | |
0035666 | |
0097190 | |
0071222 | |
0006954 | |
0045087 | |
0006886 | |
0070266 | |
0034128 | |
0043312 | |
0006909 | |
0043123 | |
2000494 | |
0034145 | |
0034142 | |
0030134 | |
0005794 | |
0042995 | |
0031901 | |
0005783 | |
0005793 | |
0010008 | |
0031902 | |
0001891 | |
0005886 | |
0030667 | |
0005149 | |
0005543 | |
0046982 | |
0051607 | |
0002376 | |
0071650 | |
0034144 | |
0071651 | |
0032729 | |
0032755 | |
0043122 | |
0001817 | |
0045357 | |
0070671 | |
0007165 | |
0005737 | |
0005769 | |
0005768 | |
0045323 | |
0005770 | |
0016020 | |
0005622 | |
0034138 | |
0008063 | |
0004871 | |
0002224 | |
0004888 | |
0002755 | |
0034130 | |
0034134 | |
0031224 |
KEGG ID | mmu:225471 |
---|---|
hsa:353376 | |
rno:364867 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 18 |
---|
OMIM ID | 608321 |
---|
Rat chromosome position | 18q11 |
---|
Hugo ID | 21354 |
---|---|
HGNC:21354 |
Human chromosome position | 5q22.3 |
---|---|
5q23.1 |
Swiss-Prot Accession | Q86XR7 |
---|---|
Q86XR7.1 | |
Q8BJQ4 | |
Q8BJQ4.1 | |
D3ZXR7 | |
Q3U996 |
Swiss-Prot ID | TCAM2_MOUSE |
---|---|
D3ZXR7_RAT | |
TCAM2_HUMAN |
Cell Localization | Cytoplasm |
---|---|
Golgi apparatus | |
Cell membrane | |
Early endosome | |
Late endosome | |
Endoplasmic reticulum | |
Cell projection | |
Phagocytic cup |
Ensembl ID | ENSG00000243414 |
---|---|
ENSP00000415139.2 | |
ENST00000427199.2 | |
ENSMUSG00000056130 | |
ENSMUSP00000066239.3 | |
ENSMUST00000070084.10 | |
ENSRNOG00000042070 | |
ENSRNOP00000056221.2 | |
ENSRNOT00000059466.2 | |
ENSRNOT00000059466 | |
ENSMUST00000070084 | |
ENST00000427199 | |
ENSRNOP00000056221 | |
ENSMUSP00000066239 | |
ENSP00000415139 | |
ENSMUST00000070084.9 |
MGI ID | MGI:3040056 |
---|---|
3040056 |
RGD ID | 1308258 |
---|
Unigene ID | Rn.225789 |
---|---|
Mm.149280 | |
Hs.718838 | |
Hs.709120 | |
Mm.484659 |
Homologene ID | 11014 |
---|
IPI ID | IPI00222444 |
---|---|
IPI00782769 | |
IPI00360266 |