Protein RIPK1

URN urn:agi-llid:8737
Total Entities 0
Connectivity 2755
Name RIPK1
Description receptor (TNFRSF)-interacting serine-threonine kinase 1
Notes This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway mTOR Signaling Hyperfunction
SIRT2 Signaling in Aging
TLR4 Signaling in Leukocytes
Peripheral T-Cell Tolerance
T-Cell Cytotoxic Mediated Cell Death
Necrosis
Eosinophil Survival by Cytokine Signaling
Apoptosis
SCF/FBXO7 Complex
Myocardial Infarction
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Podocyte Dysfunction in Diabetic Nephropathy
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction in Diabetes Mellitus Type 1
Hashimoto's Thyroiditis
Apoptosis of Thyroid Cell in Hashimoto's Thyroiditis
T-Cell Cytotoxic Response in Ulcerative Colitis
Hodgkin Lymphoma
Splenic Marginal Zone Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
Multiple Myeloma
Dendritic Cell Dysfunction in Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
FAS Mediated Apoptosis in Systemic Scleroderma
Dentin and Enamel Dysruprion in Bloch-Sulzberger Syndrome
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
OPTN Effects on NF-kB Signaling in Glaucoma
OPTN Associated Glaucoma
Podocyte Dysfunction in Glomerulonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Effector T-cell Inactivation in Cancer Immune Escape
TNF-alpha/TNFRSF1A Signaling
TNF-alpha/TNFRSF1B Signaling
NF-kB Canonical Signaling
Model of PPARG signaling in psoriasis
sars-cov binding
1_Inflammation in keratinocytes in the pathology of acne
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Chondrocyte death in osteoarthritis
2_Podocyte dysfunction in glomerulonephritis
2_Lipotoxicity in NAFLD
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D

Group binding partnetrs for SARSs

MedScan ID 8737

LocusLink ID 8737
19766
306886

Alias Ripk1
receptor-interacting protein kinase 1
OTTHUMP00000039163
receptor (TNFRSF)-interactive serine-threonine kinase I
receptor-interacting protein 1
D330015H01
IMD57
RIP1
Ripk I
receptor (TNFRSF)-interacting serine-threonine kinase I
Cell death protein RIP
RIKEN cDNA D330015H01 gene
RIP1 kinase
Serine/threonine protein kinase RIP
receptor (TNFRSF)-interacting serine-threonine kinase 1
receptor (TNFRSF)-interactive serine-threonine kinase 1
Rinp
FLJ39204
D330015H01Rik
RIP
receptor-interacting serine/threonine-protein kinase 1
OTTHUMP00000015955
TNFRSF-interacting protein
TNFRSF interacting protein
RIP-1
serine/threonine-protein kinase RIP
receptor interacting protein
Ripk1_predicted
Cell death protein RIP

EC Number 2.7.11.1

GO ID 0005524
0004706
0070513
0005123
0004672
0004674
0044877
0031625
0007249
0000165
0002756
0070231
0035666
0007256
0007257
0006919
1990000
0006915
0097190
0044257
0071363
0070301
0071356
0071550
0097191
0070266
0097527
2000134
0043124
0060044
2001237
2001240
1902042
0036289
0043123
0046330
0051092
0043065
2001238
1905206
0032757
0045651
0060545
0010940
1903800
0043068
0001934
2000379
0045944
0032760
1903265
0097300
0046777
0016579
0051291
0051260
0070926
1902041
0010803
0034612
0097343
1901026
0034138
0033209
0016032
0005829
0031264
0010008
0045121
0005739
0043235
0097342
0016301
0000166
0016740
0016310
0043410
0010942
0042327
0012501
2000377
0007165
0005737
0016020
0005886
0032991
0032403
0097296
0010939
0051347
0006468
0043234
0045087
0032481
2001239
0034142
0002224
0016772
0008063
0008633
0006917
0060555
2001243
0019048
0008624
0045768
0010552
0004872
0080010
0005515
0004713

KEGG ID hsa:8737
mmu:19766
rno:306886

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 13 14.01 cM
13 13.9 cM

OMIM ID 603453
618108

Rat chromosome position 17p12

Hugo ID 10019
HGNC:10019

Human chromosome position 6p25.2

Swiss-Prot Accession A0A024QZU0
Q13546
Q13546.3
Q60855
Q60855.1
D3ZYL0
A0AV89
B2RAG1
B4E3F9
Q13180
Q59H33
Q3U0J3
Q8CD90

PIR ID T09479
I49299

GenBank ID NC_000006
NM_001317061
NP_001303990
NM_001354932
NP_001341861
NM_003804
NP_003795
NM_001354931
NP_001341860
XM_017011405
XP_016866894
NM_001354934
NP_001341863
NM_001354933
NP_001341862
NM_001354930
NP_001341859
XM_006715237
XP_006715300
XM_017011403
XP_016866892
XM_017011404
XP_016866893
NG_063914
AL031963
AY682848
AAT74626
CH471087
EAW55115
EAW55116
EAW55117
EAW55118
KT584386
AB208926
BAD92163
AJ420482
AK096523
BAG53315
AK304701
BAG65471
AK314176
BAG36858
BC126254
AAI26255
BC126256
AAI26257
BP228763
BX348786
CK300756
U25994
AAC50137
U50062
AAC32232
Q13546
NC_000079
XM_006516607
XP_006516670
NM_009068
NP_033094
XM_006516609
XP_006516672
XM_011244295
XP_011242597
NM_001359997
AC161117
CH466546
EDL40880
AK030959
BAC27194
AK048989
AK050301
AK086694
AK156803
BAE33860
BC050905
AAH50905
BC054542
AAH54542
BC058162
AAH58162
U25995
AAB60487
Q60855
NC_005116
XM_017600529
XP_017456018
XM_017600526
XP_017456015
XM_017600528
XP_017456017
XM_017600527
XP_017456016
XM_017600524
XP_017456013
XM_017600525
XP_017456014
XM_017600523
XP_017456012
NM_001107350
NP_001100820
AC_000085
AABR07027441
AAHX01090952
AAHX01090953
CH473977
EDL98323
XM_005249458
XP_005249515
XM_005249457
XP_005249514
XM_011514969
XP_011513271
NC_018917
AMYH02012994
HQ258488
ADR83242
AC_000035
AAHY01105183
XM_006715236
XP_006715299
AC_000138
ABBA01048621
XM_006516608
XP_006516671
CAD70625
NT_007592
NW_922984
NW_001838972
AC_000049
CR618624
NT_039578
NW_001030517
NW_047491
NW_001084723
NT_034880
Q59H33
XM_225262
XP_225262
XM_001065998
XP_001065998
XM_006253828
XP_006253890
XM_006253829
XP_006253891
AABR06091192
AABR06091193
AABR06091194

Swiss-Prot ID RIPK1_HUMAN
RIPK1_MOUSE
D3ZYL0_RAT

Cell Localization Cytoplasm
Cell membrane

Ensembl ID ENSG00000137275
ENSP00000259808.3
ENST00000259808.9
ENSMUSG00000021408
ENSMUSP00000129831.1
ENSMUST00000167374.8
ENSMUSP00000021844.8
ENSMUST00000021844.14
ENSMUSP00000128511.1
ENSMUST00000171137.1
ENSRNOG00000017787
ENSRNOP00000023962.4
ENSRNOT00000023962.5
ENSP00000369773
ENST00000380409
ENSP00000259808
ENST00000259808
ENSMUSP00000129831
ENSMUST00000167374
ENSMUSP00000021844
ENSMUST00000021844
ENSRNOP00000023962
ENSRNOT00000023962

MGI ID MGI:108212
108212

RGD ID 1310158

Unigene ID Hs.519842
Mm.374799
Rn.7572

Homologene ID 2820

Shape Sickle-vertex

IPI ID IPI00013773
IPI00939198
IPI00121472
IPI00366094