URN | urn:agi-llid:8737 |
---|---|
Total Entities | 0 |
Connectivity | 2755 |
Name | RIPK1 |
Description | receptor (TNFRSF)-interacting serine-threonine kinase 1 |
Notes | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017] |
Primary Cell Localization | Cytoplasm |
Class | Protein kinase |
ObjectType | Protein |
Pathway | mTOR Signaling Hyperfunction |
---|---|
SIRT2 Signaling in Aging | |
TLR4 Signaling in Leukocytes | |
Peripheral T-Cell Tolerance | |
T-Cell Cytotoxic Mediated Cell Death | |
Necrosis | |
Eosinophil Survival by Cytokine Signaling | |
Apoptosis | |
SCF/FBXO7 Complex | |
Myocardial Infarction | |
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus | |
Podocyte Dysfunction in Diabetic Nephropathy | |
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease | |
beta-Cell Destruction in Diabetes Mellitus Type 1 | |
Hashimoto's Thyroiditis | |
Apoptosis of Thyroid Cell in Hashimoto's Thyroiditis | |
T-Cell Cytotoxic Response in Ulcerative Colitis | |
Hodgkin Lymphoma | |
Splenic Marginal Zone Lymphoma | |
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells | |
Multiple Myeloma | |
Dendritic Cell Dysfunction in Psoriatic Arthritis | |
Osteoclast Activation in Psoriatic Arthritis | |
FAS Mediated Apoptosis in Systemic Scleroderma | |
Dentin and Enamel Dysruprion in Bloch-Sulzberger Syndrome | |
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes | |
OPTN Effects on NF-kB Signaling in Glaucoma | |
OPTN Associated Glaucoma | |
Podocyte Dysfunction in Glomerulonephritis | |
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis | |
NFKB Canonical Signaling Activation in Cancer | |
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis | |
NFKB Signaling Activation by Blocking of Tumor Suppressors | |
Apoptosis Block by Death Receptor Signaling in Cancer | |
Apoptosis Evasion in Cancer: Overview | |
Effector T-cell Inactivation in Cancer Immune Escape | |
TNF-alpha/TNFRSF1A Signaling | |
TNF-alpha/TNFRSF1B Signaling | |
NF-kB Canonical Signaling | |
Model of PPARG signaling in psoriasis | |
sars-cov binding | |
1_Inflammation in keratinocytes in the pathology of acne | |
1_TNF and IL1B provoke ECM degradation in osteoarthritis | |
1_Osteoclast-mediated bone resorption in postmenopausal women | |
2_Chondrocyte death in osteoarthritis | |
2_Podocyte dysfunction in glomerulonephritis | |
2_Lipotoxicity in NAFLD | |
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection | |
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D |
Group | binding partnetrs for SARSs |
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MedScan ID | 8737 |
---|
LocusLink ID | 8737 |
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19766 | |
306886 |
Alias | Ripk1 |
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receptor-interacting protein kinase 1 | |
OTTHUMP00000039163 | |
receptor (TNFRSF)-interactive serine-threonine kinase I | |
receptor-interacting protein 1 | |
D330015H01 | |
IMD57 | |
RIP1 | |
Ripk I | |
receptor (TNFRSF)-interacting serine-threonine kinase I | |
Cell death protein RIP | |
RIKEN cDNA D330015H01 gene | |
RIP1 kinase | |
Serine/threonine protein kinase RIP | |
receptor (TNFRSF)-interacting serine-threonine kinase 1 | |
receptor (TNFRSF)-interactive serine-threonine kinase 1 | |
Rinp | |
FLJ39204 | |
D330015H01Rik | |
RIP | |
receptor-interacting serine/threonine-protein kinase 1 | |
OTTHUMP00000015955 | |
TNFRSF-interacting protein | |
TNFRSF interacting protein | |
RIP-1 | |
serine/threonine-protein kinase RIP | |
receptor interacting protein | |
Ripk1_predicted | |
Cell death protein RIP |
EC Number | 2.7.11.1 |
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GO ID | 0005524 |
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0004706 | |
0070513 | |
0005123 | |
0004672 | |
0004674 | |
0044877 | |
0031625 | |
0007249 | |
0000165 | |
0002756 | |
0070231 | |
0035666 | |
0007256 | |
0007257 | |
0006919 | |
1990000 | |
0006915 | |
0097190 | |
0044257 | |
0071363 | |
0070301 | |
0071356 | |
0071550 | |
0097191 | |
0070266 | |
0097527 | |
2000134 | |
0043124 | |
0060044 | |
2001237 | |
2001240 | |
1902042 | |
0036289 | |
0043123 | |
0046330 | |
0051092 | |
0043065 | |
2001238 | |
1905206 | |
0032757 | |
0045651 | |
0060545 | |
0010940 | |
1903800 | |
0043068 | |
0001934 | |
2000379 | |
0045944 | |
0032760 | |
1903265 | |
0097300 | |
0046777 | |
0016579 | |
0051291 | |
0051260 | |
0070926 | |
1902041 | |
0010803 | |
0034612 | |
0097343 | |
1901026 | |
0034138 | |
0033209 | |
0016032 | |
0005829 | |
0031264 | |
0010008 | |
0045121 | |
0005739 | |
0043235 | |
0097342 | |
0016301 | |
0000166 | |
0016740 | |
0016310 | |
0043410 | |
0010942 | |
0042327 | |
0012501 | |
2000377 | |
0007165 | |
0005737 | |
0016020 | |
0005886 | |
0032991 | |
0032403 | |
0097296 | |
0010939 | |
0051347 | |
0006468 | |
0043234 | |
0045087 | |
0032481 | |
2001239 | |
0034142 | |
0002224 | |
0016772 | |
0008063 | |
0008633 | |
0006917 | |
0060555 | |
2001243 | |
0019048 | |
0008624 | |
0045768 | |
0010552 | |
0004872 | |
0080010 | |
0005515 | |
0004713 |
KEGG ID | hsa:8737 |
---|---|
mmu:19766 | |
rno:306886 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 13 14.01 cM |
---|---|
13 13.9 cM |
OMIM ID | 603453 |
---|---|
618108 |
Rat chromosome position | 17p12 |
---|
Hugo ID | 10019 |
---|---|
HGNC:10019 |
Human chromosome position | 6p25.2 |
---|
Swiss-Prot Accession | A0A024QZU0 |
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Q13546 | |
Q13546.3 | |
Q60855 | |
Q60855.1 | |
D3ZYL0 | |
A0AV89 | |
B2RAG1 | |
B4E3F9 | |
Q13180 | |
Q59H33 | |
Q3U0J3 | |
Q8CD90 |
PIR ID | T09479 |
---|---|
I49299 |
Swiss-Prot ID | RIPK1_HUMAN |
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RIPK1_MOUSE | |
D3ZYL0_RAT |
Cell Localization | Cytoplasm |
---|---|
Cell membrane |
Ensembl ID | ENSG00000137275 |
---|---|
ENSP00000259808.3 | |
ENST00000259808.9 | |
ENSMUSG00000021408 | |
ENSMUSP00000129831.1 | |
ENSMUST00000167374.8 | |
ENSMUSP00000021844.8 | |
ENSMUST00000021844.14 | |
ENSMUSP00000128511.1 | |
ENSMUST00000171137.1 | |
ENSRNOG00000017787 | |
ENSRNOP00000023962.4 | |
ENSRNOT00000023962.5 | |
ENSP00000369773 | |
ENST00000380409 | |
ENSP00000259808 | |
ENST00000259808 | |
ENSMUSP00000129831 | |
ENSMUST00000167374 | |
ENSMUSP00000021844 | |
ENSMUST00000021844 | |
ENSRNOP00000023962 | |
ENSRNOT00000023962 |
MGI ID | MGI:108212 |
---|---|
108212 |
RGD ID | 1310158 |
---|
Unigene ID | Hs.519842 |
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Mm.374799 | |
Rn.7572 |
Homologene ID | 2820 |
---|
Shape | Sickle-vertex |
---|
IPI ID | IPI00013773 |
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IPI00939198 | |
IPI00121472 | |
IPI00366094 |