Pathway
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Osteoarthritis
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Fatty Acids Block TLR Signaling in Enteroendocrine Cell
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I-cell: CCK-8 Secretion and Regulation of Eating Behavior
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Toll-like Receptors Act through MYD88-TIRAP Signaling
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Antiviral Signaling through Pattern Recognition Receptors
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Toll-like Receptors Act through MYD88 Signaling
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TLR4 Signaling in Leukocytes
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Th1-Cell Differentiation
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Th17-Cell Differentiation
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Toll-like Receptors in Sterile Inflammation
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Toll-like Receptor Independent Sterile Inflammation
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Basophil Activation
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Eosinophil Survival by Cytokine Signaling
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Mast-Cell Activation without Degranulation
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Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
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Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
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Macrophage M1 Lineage
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CD16/CD14 Proinflammatory Monocyte Activation
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AHR Signaling in M1 Macrophages Function
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anti-Inflammatory Function of Macrophage M2 Lineage
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AXL Receptor Inhibits Macrophages and Dendritic Cells Function
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Neutrophil Recruitment and Priming
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Negative Acute Phase Proteins Synthesis
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Positive Acute Phase Proteins Synthesis
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Vascular Endothelial Cell Activation by Cytokines
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Vascular Endothelial Cell Activation by Blood Coagulation Factors
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Adipokines Production by Adipocyte
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IL1B Expression Targets -> Nociception
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Proteins Involved in Atherosclerosis
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Dendritic Cells Function in Atherosclerosis
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RAGE/AGER and S100 Proteins in Cardiovascular Injury
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Th1-Cells Activation and Proliferation in Atherosclerosis
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Myocardial Infarction
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Proteins Involved in Myocardial Ischemia
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Lymphocyte Mediated Myocardial Injury in Myocarditis
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Proteins Involved in Myocarditis
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Toll-like Receptors (TLR) in Antiviral Innate Immune Response
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Inflammatory Reaction in Acne Vulgaris
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Keratinocyte Proliferation in Acne Vulgaris
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Mast-Cells Activation in Atopic Dermatitis
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Dendritic Cells Function in Psoriasis
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Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
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Dendritic Cell Activation in Systemic Lupus Erythematosis
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Th17-Cell Function in Systemic Lupus Erythematosus
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Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
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Vitiligo
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T-Cell Cytotoxic Response against Melanocytes in Vitiligo
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Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
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TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
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Toll-like Receptors in beta-Cell
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TLR7 and TLR9 in Plasmacytoid Dendritic Cell
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Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
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Insulin Resistance in Myocytes Induced by Obesity
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Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
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beta-Cell Destruction through Cytokines in Diabetes Mellitus
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beta-Cell Destruction in Diabetes Mellitus Type 1
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Adipokines Production by Adipocyte Impaired in Obesity
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CD4+T-Cell Response in Celiac Disease
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Celiac Disease
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Crohn's Disease
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Dendritic Cell Dysfunction in Crohn's disease
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Dendritic Cell Function in Ulcerative Colitis
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Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
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Nicotine anti-Inflammatory Effect in Ulcerative Colitis
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Antiphospholipid Antibodies in Endothelial Cell
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B-Cell Chronic Lymphocytic Leukemia
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Diffuse Large-B-Cell Lymphoma
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Diffuse Large-B-Cell Lymphoma ABC Subtype
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Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
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Splenic Marginal Zone Lymphoma
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Antiphospholipid Antibodies and Endothelial Cell Interaction
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IL33 Signaling Related Eosinophilia in Asthma
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TSLP Signaling in Bronchial Epithelial Cell in Asthma
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Club-Cell Role in Asthma
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Basophil Activation in Asthma
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Antigen-Presenting Cell Role in Asthma
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Th17-Cell Differentiation in Asthma
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Mucin Production in Goblet Airway Epithelial Cells
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CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
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Airway Epithelial Cell Dysfunction
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CFTR Expression in Epithelial Cells (Class I Mutations)
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Osteoclast Activation in Gout
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Neutrophil Recruitment in Sinovium in Gout
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Monocytes Function in Gout
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TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
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IL1B Induced Arthralgia
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Dendritic Cell Dysfunction in Psoriatic Arthritis
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Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
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Osteoclast Activation in Psoriatic Arthritis
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Synovial Fibroblast Activation in Psoriatic Arthritis
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Osteoclast Activation in Rheumatoid Arthritis
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Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
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TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
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Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
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Th17-Cell Numbers Reduction in HIV
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Toll-like Receptors (TLR) in Periodontitis
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IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
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PAPA Syndrome
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TNF Receptor Associated Periodic Syndrome
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Mevalonate Kinase Deficiency
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Blau Syndrome
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IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
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Cryopyrin (NLPR3) Associated Periodic Syndromes
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Familial Cold Autoinflammatory Syndrome 2
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Familial Mediterranean Fever
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Majeed Syndrome
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Gluten Impact on Neuronal System (Hypothesis)
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Microglia Activation in Alzheimer's Disease
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HMGB1 and IL1B in Neuroinflammation
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Microglia Activation in Parkinson's Disease
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Subepithelial Fibroblasts in Middle Ear Cholesteatoma
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Cholesteatoma
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HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
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Cytokines Trigger Otitis Media
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MUC5AC Expression by NTHi and S. Pneumoniae
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Immune System Role in Otitis Media
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Alveolar Macrophage Negative Regulation Declined in COPD
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Alveolar Macrophages Dysfunction in COPD
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T-Cell Cytotoxic Activation
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Alveolar Epithelial Cell Dysfunction in COPD
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Mucin Hyperproduction in Goblet and Mucous Cells
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Endothelial Cell Dysfunction in Glomerulonephritis
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Toll-like Receptors in Pyelonephritis
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Endothelial Cell Dysfunction in Pyelonephritis
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NFKB Canonical Signaling Activation in Cancer
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STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
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NFKB Signaling Activation by Blocking of Tumor Suppressors
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IDO1 in Cancer Immune Escape
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IL1R -> STAT3 Signaling
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IL1R -> NF-kB Signaling
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NF-kB Canonical Signaling
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TLR4 -> AP-1 Expression Targets
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TLR5 Expression Targets
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TLR7 Expression Targets
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TLR4 -> AP-1/EGR1/HIF1A Expression Targets
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TLR1 -> 2/6 Expression Targets
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IL1B Expression Targets
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TLR4 -> NF-kB/IRF Expression Targets
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IL1A Expression Targets
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TLR9 Expression Targets
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TLR4 -> IRF Signaling
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TLR4/5/7/9 -> NF-kB Signaling
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TLR1/2/6 -> NF-kB Signaling
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TLR -> AP-1 Signaling
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pathway 4
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|
Model of PPARG signaling in psoriasis
|
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Model of PPARG related pathways in psoriasis (short version)
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dsRNA induces innate immunity and INFs in alveolar cells
|
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Innate immunity in Leukocytes
|
|
AGER feed forward loop in innate immunity
|
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Dendritic Cell Activation in COVID19
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|
1_Inflammation in keratinocytes in the pathology of acne
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2_Acute phase initiation in atopic dermatitis
|
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1_TNF and IL1B provoke ECM degradation in osteoarthritis
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2_Chondrocyte death in osteoarthritis
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1_The role of Toll-like receptors in pyelonephritis
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2_The role of endothelial cells in pyelonephritis
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1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
|
|
2_Pathogens stimulate mucins expression in the middle ear
|
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3_Arterial wall inflammation and calcification in atherosclerosis
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1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
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3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
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1_Th2 cell response in asthma
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3_1_Mucus accumulation in asthma
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2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
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4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
|
|
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
|
|
1_Intestine epithelial cell dysfunction in ulcerative colitis
|
|
2_Lipotoxicity in NAFLD
|
|
1_CD4+ T cell and epithelial cell response in celiac disease
|
|
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
|
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4_3_Insulin resistance: FFA-related insulin resistance
|
|
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
|
|
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
|
|
3_Islet beta-cell destruction in T1D
|
|
2_Neuron and Schwann cell death
|
|
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
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