Protein IL1R1

URN urn:agi-llid:3554
Total Entities 0
Connectivity 1333
Name IL1R1
Description interleukin 1 receptor, type I
Notes This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Osteoarthritis
Th17-Cell Differentiation
Bradykinin Effects in Inflammation
Toll-like Receptor Independent Sterile Inflammation
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
anti-Inflammatory Function of Macrophage M2 Lineage
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
IL1B Expression Targets -> Nociception
CD8+ Naive T-cell -> CD4+ Naive T-cell Surface Expression Markers
Megakaryocyte -> Platelet Precursor Cell Surface Expression Markers
T-lymphoid precursor cell -> CD8+ Naive T-cell Surface Expression Markers
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Nitric Oxide Effects on beta-Cell
CD4+T-Cell Response in Celiac Disease
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Th17-Cell Differentiation in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Th17-Cell Numbers Reduction in HIV
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
HMGB1 and IL1B in Neuroinflammation
HMGB1 and IL1B in Neuronal Hyperexcitation
Proteins Involved in Endometriosis
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cytokines Trigger Otitis Media
Alveolar Macrophages Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Blood Vessel
Elevated Receptors -> Expression Targets in Small Intestine
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
IDO1 in Cancer Immune Escape
IGF1 -> CEBPA/FOXO1A Expression Targets
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
IL6 Expression Targets
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Nerve Tissue
NF-kB Canonical Signaling
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B Expression Targets
IL1A Expression Targets
PPAR Psoriasis
Model of PPARG signaling in psoriasis
1_Inflammation in keratinocytes in the pathology of acne
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
2_The role of endothelial cells in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
Differentiation of psoriatic T cells

MedScan ID 3554

LocusLink ID 3554
16177
25663

Alias OTTHUMP00000161344
interleukin IL1R_HUMAN
D2S1473
MGC129154
IL1 Receptor alpha
interleukin 1 receptor, type I
IL1R I
OTTHUMP00000203891
interleukin 1 receptor 1
interleukin IL1 receptor alpha
CD121a antigen
IL-iR
interleukin 1 receptors type I
CD121a
interleukin IL1 receptor 1
IL1 receptor I
interleukin 1 beta receptor type 1 short transmembrane form
IL-1R-alpha
interleukin IL1 receptor alpha, type I
IL1 receptor 1
IL-1RT1
OTTHUMP00000203889
IL1R1
interleukin IL1R I
interleukin 1 receptors type 1
interleukin 1 receptor alpha, type 1
OTTHUMP00000203888
OTTHUMP00000203887
interleukin IL1 receptor I
interleukin 1 receptor alpha, type I
IL1R_HUMAN
CD121 antigen-like family member A
interleukin IL1 receptor alpha, type 1
interleukin 1 bete receptor type 1 long transmembrane form
Antigen CD121a
OTTHUMP00000207977
interleukin IL-1R-alpha
interleukin-1 receptor alpha
interleukin IL1R1
interleukin 1 beta receptor type 1 soluble form
interleukin 1 beta receptor type 1 long transmembrane form
P80
IL1R
IL1RA
IL-1R-1
IL-1RT-1
interleukin-1 receptor type I
interleukin-1 receptor type 1
CD121b
IL-1R1
Il1r-1
IL-1 receptor alpha chain
IL1RT1
interleukin receptor 1

GO ID 0019966
0004908
0004909
0005161
0002020
0004888
0007166
0019221
0006955
0006954
0070498
2000556
0032729
2000661
2000391
0050727
0070555
0009897
0005576
0005887
0016020
0005886
0035255
0010286
2001224
0009314
0007165
0030424
0009986
0005615
0016021
0005634
0014069
0032991
0071333
0030728
0070849
0071731
1990834
0071559
0004871
0043234
0045087
0005622
0031224
0004872

KEGG ID hsa:3554
mmu:16177
rno:25663

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 1 18.81 cM
1 19.5 cM

OMIM ID 147810

Rat chromosome position 9q22
9q21

Hugo ID 5993
HGNC:5993

Human chromosome position 2q11.2-q12.1
2q12

Swiss-Prot Accession P14778
B8ZZW4
P14778.1
Q8C6P3
Q8C833
P13504
Q32MH0
P13504.1
Q05KR1
Q05KR0
A0A0G2K6N4
Q02955.1
Q587I7
Q02955
Q6NWP5
Q6NWP6
Q05KR2
Q62692
Q76LI4

PIR ID A36187
A32604

GenBank ID NC_000002
XM_011511117
XP_011509419
NM_001320978
NP_001307907
NM_001288706
NP_001275635
XM_011511115
XP_011509417
NM_001320980
NP_001307909
NM_001320986
NP_001307915
XM_011511116
XP_011509418
XM_017003989
XP_016859478
NM_001320981
NP_001307910
XM_005263930
XP_005263987
NM_001320982
NP_001307911
NM_000877
NP_000868
XM_005263934
XP_005263991
XM_011511118
XP_011509420
NM_001320985
NP_001307914
NM_001320984
NP_001307913
NM_001320983
NP_001307912
AC007271
AAX81988
AF172151
AF190052
AF366364
AF531102
AAM88423
AH008153
AX530423
CAD57171
CH471127
EAX01799
JA738563
CCF76934
KF456690
S81089
AK026803
AK314433
AL548240
AU136426
BC067506
AAH67506
BC067507
AAH67507
BC067508
AAH67508
BC075062
AAH75062
BC075063
AAH75063
BE144272
BQ021163
BX472731
CA421991
CB240976
CD013912
CD013913
CD014140
DA333942
DA861783
DB226934
HY092388
M27492
AAA59137
X16896
CAA34773
P14778
NC_000067
XM_006495713
XP_006495776
XM_006495719
XP_006495782
XM_006495722
XP_006495785
NM_008362
NP_032388
XM_017317595
XP_017173084
XM_017317613
XP_017173102
XM_006495723
XP_006495786
XM_006495721
XP_006495784
XM_011238436
XP_011236738
XM_006495715
XP_006495778
XM_006495720
XP_006495783
XM_006495714
XP_006495777
NM_001123382
NP_001116854
XM_006495717
XP_006495780
AC135085
AC167168
CH466536
EDL14572
AK048550
BAC33372
AK054137
BAC35666
AK166301
BC109135
AAI09136
M20658
AAA39279
P13504
NC_005108
XM_006244753
XP_006244815
XM_006244747
XP_006244809
XM_006244752
XP_006244814
XM_006244748
XP_006244810
XM_006244750
XP_006244812
XM_006244746
XP_006244808
XM_006244754
XP_006244816
XM_006244749
XP_006244811
XM_008766993
XP_008765215
XM_006244751
XP_006244813
NM_013123
NP_037255
AC_000077
AABR07067457
AABR07067458
AAHX01059540
AAHX01059541
AAHX01059542
AAHX01059543
CH473965
EDL99179
EDL99180
EDL99181
AB079118
BAD15353
AB112436
BAF34663
AB112437
BAF34664
AB112438
BAF34665
M95578
AAA16196
U14010
AAA50243
Q02955
AF146426
AF146427
XM_005263932
XP_005263989
XM_005263929
XP_005263986
XM_005263931
XP_005263988
XM_011511114
XP_011509416
XM_011511120
XP_011509422
XM_011511119
XP_011509421
XM_005263933
XP_005263990
NC_018913
AMYH02004435
XM_006495716
XP_006495779
XM_006495718
XP_006495781
AC_000023
AAHY01005650
AAHY01005651
AAHY01005652
AAHY01005653
AAHY01005654
AAHY01005655
AAHY01005656
XR_244889
AC_000134
ABBA01073900
NT_022171
NW_001838818
NW_928052
AC_000045
CR595183
CR621155
Q6NWP5
Q6NWP6
NT_039170
NW_001030649
Q32MH0
Q8C6P3
Q8C833
NW_047814
NW_001084882
Q05KR0
Q05KR1
Q05KR2
Q62692
Q76LI4

Swiss-Prot ID IL1R1_HUMAN
IL1R1_MOUSE
Q32MH0_MOUSE
Q05KR1_RAT
Q8C6P3_MOUSE
Q8C833_MOUSE
Q587I7_HUMAN

Cell Localization Membrane
Cell membrane
Secreted
Plasma membrane

Ensembl ID ENSG00000115594
ENSP00000386380.1
ENST00000410023.6
ENSP00000386776.1
ENST00000409929.5
ENSP00000386555.1
ENST00000409589.5
ENSMUSG00000026072
ENSMUSP00000110443.1
ENSMUST00000114795.2
ENSMUSP00000027241.4
ENSMUST00000027241.10
ENSRNOG00000014504
ENSRNOP00000072248.1
ENSRNOT00000082408.1
ENSRNOP00000073880.1
ENSRNOT00000082146.1
ENSRNOP00000019673.3
ENSRNOT00000019673.4
ENSRNOP00000075417.1
ENSRNOT00000087112.1
ENST00000410023.5
ENSP00000386380
ENST00000410023
ENSP00000386776
ENST00000409929
ENSMUSP00000110443
ENSMUST00000114795
ENSMUSP00000027241
ENSMUST00000027241
ENSRNOP00000072248
ENSRNOT00000082408
ENSRNOP00000073880
ENSRNOT00000082146
ENSRNOP00000019673
ENSRNOT00000019673
ENSRNOP00000075417
ENSRNOT00000087112

MGI ID MGI:96545
96545

RGD ID 2892

TCDB ID 8.A.23.1.11

Unigene ID Rn.9758
Hs.701982
Mm.896

Homologene ID 677

Shape Stick-vertex

IPI ID IPI00122581
IPI00027508
IPI00231728
IPI00875537