Pathway
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Proteins Involved in Stem Cell Exhaustion in Aging
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Androgen Deficiency in Male Obesity
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Hypoxia Inhibits mTOR Signaling
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SIRT6 Signaling in Aging
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P-cell Activation
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Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
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Androgens in Adipocyte Activation
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T-Cell Maturation (Hypothesis)
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Mast-Cell Activation via IgE Signaling
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Macrophage Related Iron Uptake and Release
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Negative Acute Phase Proteins Synthesis
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Positive Acute Phase Proteins Synthesis
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Adipokines Production by Adipocyte
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IL1B Expression Targets -> Nociception
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Circadian Clock in Sleep Regulation
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Proteins Involved in Arterial Hypertension
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Proteins Involved in Pulmonary Hypertension
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Proteins Involved in Hypoxia-Induced Pulmonary Hypertension
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Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
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Proteins Involved in Myocardial Ischemia
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Proteins with Altered Expression in Melanoma
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Melanoma
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MITF as a Regulator of Melanoma Cell Development
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Proteins Involved in Melanoma
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Melanocyte Role in Skin Aging
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Peripheral Tissue Microangiopathy
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Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
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Podocyte Dysfunction in Diabetic Nephropathy
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Proteins Involved in Diabetic Nephropathy
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Microangiopathy in Diabetic Neuropathy
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Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
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Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
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Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
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Cardiovascular Effects in Hyperthyroidism
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Adipokines Production by Adipocyte Impaired in Obesity
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Proteins Involved in Obesity
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Proteins Involved in Colorectal Neoplasms
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Metastatic Colorectal Cancer
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Peutz-Jeghers Syndrome
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B-Cell Acute Lymphoblastic Leukemia
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Osteoclast Activation in Multiple Myeloma
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IL6/IGF1/VEGFA Signaling in Multiple Myeloma
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Multiple Myeloma
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T-Cell Acute Lymphoblastic Leukemia
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Vascularization in Hepatocellular Carcinoma
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Proteins Involved in Hepatocellular Carcinoma
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WNT Signaling in Hepatocellular Carcinoma
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Hepatocellular Carcinoma
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Proteins Involved in Pancreatic Cancer
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Goblet-Cell Related Mucus Secretion in Asthma
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Mast-Cell Activation in Asthma
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Mucin Production in Goblet Airway Epithelial Cells
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Proteins Involved in Osteoarthritis
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FXN Role in Friedreich Ataxia Progression
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Proteins Involved in Epilepsy
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Proteins Involved in Glioblastoma
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Glioblastoma, Secondary
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Astrocytoma
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Proteins Involved in Glioma
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Proteins Involved in Neuroblastoma
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Proteins Involved in Amyotrophic Lateral Sclerosis
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Proteins Involved in Vascular Dementia
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Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
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Proteins Involved in Endometrial Cancer
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Proteins Involved in Endometriosis
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Clear Cell Ovarian Carcinoma
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Ovarian Cancer
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Proteins Involved in Clear Cell Ovarian Carcinoma
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Proteins with Altered Expression in Ovarian Cancer
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HPV Infection and Cancer
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HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
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Prostate Cancer
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Androgen Receptor/c-Met Signaling in Prostate Cancer
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FOXA2 Signaling in Prostate Cancer
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Proteins Involved in Prostate Cancer
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Netrin-1 Signaling in Age-Related Macular Degeneration
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Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
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HIF1A in Pathologic Ocular Neovascularization
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VEGFA in Neovascular Glaucoma
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Mucin Hyperproduction in Goblet and Mucous Cells
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Endothelial Cell Dysfunction in Glomerulonephritis
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Podocyte Dysfunction in Glomerulonephritis
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Proteins with Altered Expression in Prostate Cancer
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Endothelial Cell Dysfunction in Pyelonephritis
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AREG -> HIF1A Expression Targets
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Noradrenaline/Gs Expression Targets
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Noreadrenaline/Gq Expression Targets
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Elevated Receptors -> Expression Targets in Myocardium
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CCL3 Expression Targets
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CCL2 Expression Targets
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EGF -> CTNN Expression Targets
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EGF -> HIF1A Expression Targets
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EGF -> AP-1/ATF Expression Targets
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EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
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EGF -> MEF/MYOD/NFATC Expression Targets
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EGF -> STAT Expression Targets
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EGFR/ERBB2 -> HIF1A Signaling
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EREG -> HIF1A Expression Target
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F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
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F2 -> STAT1/NF-kB Expression Targets
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FGF2 -> STAT Expression Targets
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FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
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HBEGF -> HIF1A Expression Targets
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HGF -> STAT Expression Targets
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STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
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Apoptosis Block by Inhibitor of Apoptosis Proteins (IAPs) in Cancer
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Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
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Suppression of Caspase Activity in Cancer
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Apoptosis Evasion in Cancer: Overview
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Hypoxia-Induced Cell Death Evasion in Cancer
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Apoptosis Block by BCL2 Family Proteins in Cancer
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HIF1A in Vasculogenic Mimicry of Cancer
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VEGFA Dependent Angiogenesis in Cancer
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FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
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HIF1A as Master Regulator of Angiogenesis in Cancer
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Proteins with Altered Expression in Cancer Metastases
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Epithelial to Mesenchymal Transition in Cancer: Overview
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BSG (CD147) in Cancer Cells Motility, Invasion and Survival
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Metabolic Reprogramming in Cancer: Overview
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Respiratory Chain Impairment in Cancer
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Lactate as a Signaling Molecule in Cancer Cells
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Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
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Mutations in Krebs Cycle Enzymes in Cancer
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Glycolysis Activation in Cancer (Warburg Effect)
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Proteins with Altered Expression in Cancer Metabolic Reprogramming
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Treg Cells Promote Immunosuppression in Cancer Immune Escape
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Adenosine/cAMP Promote Immunosuppression by Treg Cells
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EZH2 Methyltransferase Role in Cancer
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IGF1 -> MEF/MYOD/MYOG Expression Targets
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IGF2 -> STAT Expression Targets
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IGF1 -> STAT Expression Targets
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IGF2 -> HIF1A/MYC Expression Targets
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IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
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Insulin -> STAT Expression Targets
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Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
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Insulin -> MEF/MYOD Expression Targets
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Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
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IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
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EGFR -> Expression Targets in Skin
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NOTCH -> Expression Targets in Skin
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IFNG/IFNR Expression Targets
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IL3 Expression Targets
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IL6 Expression Targets
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Prostaglandin F Expression Targets
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LPA Expression Targets
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S1P Expression Targets
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TNF Receptors -> Expression Targets in Lymphoid System and Blood
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NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
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NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
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NRG1/Catenin Expression Targets
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NRG1 -> STAT Expression Targets
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NRG1 -> AP-1/ATF Expression Targets
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NRG1 -> HIF1A Expression Target
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Elevated Receptors -> Expression Targets in Nerve Tissue
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BDNF Expression Targets
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Adenosine Expression Targets
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PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
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PDGF -> STAT Expression Targets
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AGT -> CREB Expression Targets
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TAC1 Expression Targets
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AGT -> STAT Expression Targets
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PRL/PRLR Expression Targets
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PRL/GHR -> STAT Expression Targets
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PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
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CSF1 -> STAT Expression Targets
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KITLG -> STAT Expression Targets
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KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
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CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
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PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
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Elevated Receptors -> Expression Targets in Breast
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HIF1 Signaling
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TGFA -> HIF1A Expression Targets
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TGFB1-TGFBR2 Expression Targets
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TGFB1-TGFBR1/AP-1 Expression Targets
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TGFB1-ACVRL1 Expression Targets
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TNF -> NF-kB Expression Targets
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TNF -> AP-1 Expression Targets
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TNF -> STAT Expression Targets
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Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
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Thrombopoietin -> STAT Expression Targets
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IL1B -> NO Expression Targets
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TLR4 -> AP-1/EGR1/HIF1A Expression Targets
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IL1B -> PGE2 Expression Targets
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TLR1 -> 2/6 Expression Targets
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IL1B Expression Targets
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IL1A Expression Targets
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Mitochondrial Damage Induced by Hypoxia
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Elevated Receptors -> Expression Targets in Kidney
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pprarg neg, uknown targets, ps-positive
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Model of PPARG signaling in psoriasis
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PPARG negative regulators and targets
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Model of PPARG related pathways in psoriasis (short version)
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New Pathway
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1_TNF and IL1B provoke ECM degradation in osteoarthritis
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2_Chondrocyte death in osteoarthritis
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2_The role of endothelial cells in pyelonephritis
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2_Podocyte dysfunction in glomerulonephritis
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2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
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3_1_Mucus accumulation in asthma
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4_Mucin hyperproduction in goblet and mucous cells in COPD
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3_Human papilloma virus E4 and E5 proteins in viral reproduction
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1_Microangiopathy in diabetic neuropathy
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drug-target pairs direct regulation
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drug-target molsynthesis
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