Protein TGFA

URN urn:agi-llid:7039
Total Entities 0
Connectivity 3423
Name TGFA
Description transforming growth factor alpha
Notes This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Primary Cell Localization Extracellular
Class Ligand

Pathway Prostaglandin E2 and Histamine in Gastric Acid Secretion
Gastric and Pancreatic Lipase Function
G0/G1 Phase Transition
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Proteins Involved in Psoriasis
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in Prolactinoma
Cetuximab Resistance in Colorectal Cancer
Metastatic Colorectal Cancer
Proteins Involved in Ulcerative Colitis
Vascularization in Hepatocellular Carcinoma
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
Goblet-Cell Related Mucus Secretion in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Proteins Involved in Polycystic Ovary Syndrome
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Glioma Invasion Signaling
Proteins Involved in Glioma
Proteins Involved in Neuroblastoma
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Proteins Involved in Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins with Altered Expression in Endometrial Cancer
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
Proteins Involved in Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
Proteins Involved in Pulmonary Emphysema
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins with Altered Expression in Cystic Fibrosis
Proteins Involved in Polycystic Kidney Disease
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR -> CTNND Signaling
EGFR/ERBB2 -> TP53 Signaling
EGFR/ERBB2 -> CTNNB Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> ZNF259 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EGFR/ERBB -> STAT Signaling
EGFR Transactivation in Cancer and Non-Cancer Cells
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
G0/G1 Cell Cycle Phase Transition Activation in Cancer
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> STAT Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
EGFR -> Expression Targets in Skin
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1/Catenin Expression Targets
NRG1 -> STAT Expression Targets
NRG1 -> AP-1/ATF Expression Targets
NTF3 Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
Elevated Receptors -> Expression Targets in Breast
Estrogens/ESR1 Genomic Canonical Signaling
EGFR Signaling
TGFA -> STAT Expression Targets
TGFA -> FOXO3A Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
IL1B Expression Targets
IL1A Expression Targets
Dioxin Induced Chloracne (Hypothesis)
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of disease-free survival
Neighbors of long-term survival
Neighbors of body weight
Neighbors of body weight gain
Neighbors of microvessel density
Neighbors of tumor promotion
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of vascular density
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of glucose level
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of skin thickness
Neighbors of fibroblast phenotype
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of disease-free survival
Neighbors of long-term survival
Neighbors of body weight
Neighbors of body weight gain
Neighbors of microvessel density
Neighbors of tumor promotion
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of vascular density
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of glucose level
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of skin thickness
Neighbors of fibroblast phenotype
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of cell formation
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of lung development
Neighbors of autophagy
Neighbors of transcription activation
Neighbors of senescence
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of cellular immune response
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of vascular disease
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of myocardial infarction
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of renal injury
Neighbors of liver injury
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of kidney disease
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of atrophy
Neighbors of respiratory hypersensitivity
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of microglia
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatocyte
Neighbors of endothelial cell
Neighbors of Kuppfer cell
Neighbors of inflammatory cell
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of lung fibroblast
Neighbors of mesothelial cell
Neighbors of granulocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of myofibroblast
Neighbors of mast cell
Neighbors of neuroglia
Neighbors of mammary epithelial cell
Neighbors of epidermis cell
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of heart
Neighbors of gastrointestinal tract
Neighbors of esophagus
Neighbors of stomach
Neighbors of prostate
Neighbors of villus
Neighbors of glands
Neighbors of eye
Neighbors of brain blood vessel
Neighbors of hypothalamus
Neighbors of choroid plexus
Neighbors of NF-kB family
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of transforming growth factor
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of Ras GTPase
Neighbors of growth factor
Neighbors of PKA
Neighbors of LDL
Neighbors of chorionic gonadotropin
Neighbors of NAD(P)H oxidase
Neighbors of estrogen receptor
Neighbors of HIF-1
Neighbors of AHR subfamily
Neighbors of FSH
Neighbors of TLR4/Myd88
Model of PPARG signaling in psoriasis
2_Pathogens stimulate mucins expression in the middle ear
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD

Group Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 7039

LocusLink ID 7039
21802
24827

Alias OTTHUMP00000203352
TGFAA
OTTHUMP00000203300
1MOX_Ds
TGFA
LOC150914
protransforming growth factor alpha
EGF-like TGF
RATTGFAA
TGF-alpha
OTTHUMP00000203345
LOC130089
waved 1
Transforming Growth Factor-alphahuman
TGF A
1MOX_D
wa I
type alpha transforming growth factor
OTTHUMP00000203301
ETGF
TGFA_HUMAN
Transforming growth factor alpha
tfga
wa1
wa-1
transforming growth factor, alpha
transforming growth factor-alpha
waved I

GO ID 0005154
0008083
0048208
0006888
0000165
0000187
0007173
0035556
0061024
0042059
0051781
0008284
0045741
0050679
0045840
0051897
0006357
0007165
0012507
0000139
0016323
0009986
0030665
0031410
0005789
0033116
0005576
0005615
0016021
0048471
0005886
0001525
0072574
0060749
0043066
0048523
0050731
0016020
0005634
0042493
0042060
0005887
0008283
0001948
0004708
0051480
0043524
0006916
0004871
0043526
0001934

KEGG ID hsa:7039
mmu:21802
rno:24827

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6 37.62 cM
6 35.8 cM

OMIM ID 190170

Rat chromosome position 4q34

Hugo ID 11765
HGNC:11765

Human chromosome position 2p13.3
2p13

Swiss-Prot Accession P01135
F8VNR3
E7EPT6
P01135.1
P48030
Q545E4
P48030.1
P01134
U5LKN7
P01134.2
A8K286
Q15577
Q53SK7
Q9BS56
Q9UEI3
Q9UKM1
Q9UKM2
Q9UKM3
Q63749
Q15578
Q6QBS1
Q9UE87
Q9UIS1
Q9UIS2
Q9UIS3
Q9UQ91
Q6LC37

PIR ID JN0876
S27195
A93356
I57497

GenBank ID NC_000002
NM_001099691
NP_001093161
NM_003236
NP_003227
NM_001308159
NP_001295088
NM_001308158
NP_001295087
NG_029975
AC005234
AAY14793
AC017084
AAY14705
AH003012
AAA61158
AH007317
AAD12238
AAD12239
AH008373
AAF06728
AAF06729
AAF06730
AH008439
AAF13491
AH013033
AAP97822
CH471053
EAW99810
EAW99811
EAW99812
EAW99813
EAW99814
M22440
AAA52530
M96868
AAA79958
X70341
AF149096
AAF05089
AF149097
AAF05090
AF149098
AAF05091
AK290151
BAF82840
AK309066
AK309220
AK312899
AY548763
AAS83396
BC005308
AAH05308
BI760767
BM453873
BT006833
AAP35479
CD369689
CN274505
DA216480
DA229819
DA373586
DA462271
K03222
AAA61159
M31172
AAA61157
X70340
CAA49806
P01135
NC_000072
NM_031199
NP_112476
AC159549
CH466523
EDK99158
EDK99159
U64873
AAB50553
U89794
AAC53174
AK010785
BAB27181
AK162680
BAE37019
AK165017
AK166321
BAE38704
BC132185
AAI32186
BC132211
AAI32212
BE848968
M92420
AAA40481
U65016
AAB50554
P48030
NC_005103
XM_006236822
XP_006236884
NM_012671
NP_036803
AC_000072
AABR07061351
AABR07061352
AABR07061353
AAHX01031356
AAHX01031357
AAHX01031358
AAHX01031359
CH473957
EDL91222
EDL91223
EDL91224
M31075
AAA42234
KF366251
AGX26150
M31076
AAA42233
X02004
CAA26036
X61485
X61486
X61487
P01134
XM_005264522
XP_005264579
XM_011533076
XP_011531378
NC_018913
AF075583
AF075584
AF075585
AF075586
AF123238
AF123239
AF123240
AF123241
AF123242
AF123243
AF149099
AF149100
AMYH02004039
AMYH02004040
AY325885
AY325886
AY326405
AY327131
AY327132
AY329368
K03220
K03221
AC_000028
AAHY01055020
AAHY01055021
AAHY01055022
AAHY01055023
AAHY01055024
XM_008763049
XP_008761271
XM_008763050
XP_008761272
AC_000134
ABBA01075538
ABBA01075539
NT_022184
NW_001838769
NW_927719
AC_000045
Q15578
Q6QBS1
Q9UE87
Q9UIS1
Q9UIS2
Q9UIS3
Q9UKM3
Q9UQ91
NT_039353
NW_001030811
Q545E4
Q6LC37
NW_047694
NW_001084830

Swiss-Prot ID TGFA_HUMAN
TGFA_MOUSE
TGFA_RAT
Q545E4_MOUSE
A8K286_HUMAN
Q9BS56_HUMAN

Cell Localization Secreted
Extracellular space
Cell membrane
Secreted, extracellular space
Extracellular

Ensembl ID ENSG00000163235
ENSP00000404099.2
ENST00000418333.6
ENSP00000404131.1
ENST00000444975.5
ENSP00000414127.1
ENST00000450929.5
ENSP00000295400.6
ENST00000295400.11
ENSMUSG00000029999
ENSMUSP00000032066.9
ENSMUST00000032066.12
ENSRNOG00000016182
ENSRNOP00000054248.2
ENSRNOT00000057441.4
ENSP00000404099
ENST00000418333
ENSP00000295400
ENST00000295400
ENSP00000404131
ENST00000444975
ENSP00000414127
ENST00000450929
ENSMUSP00000032066
ENSMUST00000032066
ENSRNOP00000054248
ENSRNOT00000057441

MGI ID MGI:98724
98724

RGD ID 3849

Unigene ID Hs.170009
Hs.628298
Mm.137222
Rn.9952

Homologene ID 2431

Shape Rhomb

IPI ID IPI00137996
IPI00465177
IPI00856067
IPI00872280
IPI00926333
IPI00954043
IPI00779017
IPI00462181
IPI00327408