URN | urn:agi-llid:6279 |
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Total Entities | 0 |
Connectivity | 2034 |
Name | S100A8 |
Description | S100 calcium binding protein A8 |
Notes | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
ObjectType | Protein |
Pathway | AHR in Intestinal Cell Antimicrobial Barrier Maintenance |
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Proteins Involved in Atherosclerosis | |
RAGE/AGER and S100 Proteins in Cardiovascular Injury | |
Proteins Involved in Myocarditis | |
Proteins Involved in Atopic Dermatitis | |
IL22 Induces Keratinocyte Proliferation in Psoriasis | |
Proteins with Altered Expression in Psoriasis | |
Dendritic Cells Function in Psoriasis | |
Advanced Glycation End Products Pathway in Diabetic Microangiopathy | |
Proteins Involved in Cystic Fibrosis | |
Dendritic Cell Dysfunction in Psoriatic Arthritis | |
Proteins Involved in Amyotrophic Lateral Sclerosis | |
Immune System Role in Otitis Media | |
Proteins Involved in Bronchiectasis | |
Proteins Involved in Chronic Obstructive Pulmonary Disease | |
Myeloid Derived Suppressor Cells in Cancer Immune Escape | |
IFNG/IFNR Expression Targets | |
IL10 Expression Targets | |
IL22 Expression Targets | |
GPCRs Family -> Expression Targets in Lymphoid System and Blood | |
Elevated Receptors -> Expression Targets in Bone Marrow | |
IL1A Expression Targets | |
VEGFA -> STAT Expression Targets | |
pprarg neg, uknown targets, ps-positive | |
dsRNA induces innate immunity and INFs in alveolar cells | |
AGER feed forward loop in innate immunity | |
2_Interleukin-17 and interleukin-22 signaling in psoriasis | |
3_Arterial wall inflammation and calcification in atherosclerosis | |
drug-target moltransport | |
Interleukin-17 and interleukin-22 signaling in psoriasis |
MedScan ID | 6279 |
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LocusLink ID | 6279 |
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20201 | |
116547 |
Alias | 60B8AG |
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Leukocyte L1 complex light chain | |
Cystic fibrosis antigen | |
B8Ag | |
Migration inhibitory factor-related protein 8 | |
MRP8 | |
CGLA | |
urinary stone protein band A | |
chemotactic cytokine CP-10 | |
OTTHUMP00000015329 | |
L1Ag | |
S108_HUMAN | |
CP X | |
pro-inflammatory S100 cytokine | |
S100 calcium binding protein A8 | |
Migration inhibitory factor-related protein VIII | |
OTTHUMP00000015330 | |
chemotactic s100 protein | |
S100a8 | |
CP-10 | |
AI323541 | |
CAGA protein | |
S100 calcium binding protein A8 (calgranulin A) | |
calprotectin L1L subunit | |
CAGA mRNA | |
CP10 | |
calgranulin A | |
CFAG | |
MA387 | |
P8 | |
MIF | |
NIF | |
CAGA | |
protein S100-A8 | |
MRP-8 | |
S100 calcium-binding protein A8 | |
calgranulin-A | |
S108 | |
S100 calcium-binding protein A8 (calgranulin A) |
GO ID | 0050786 |
---|---|
0035662 | |
0050544 | |
0005509 | |
0008017 | |
0008270 | |
0006919 | |
0002526 | |
0019730 | |
0006915 | |
0014002 | |
0035425 | |
0006914 | |
0032602 | |
0002544 | |
0001816 | |
0042742 | |
0050832 | |
0006954 | |
0045087 | |
0002523 | |
0070488 | |
0030593 | |
0043312 | |
0018119 | |
0051092 | |
0030307 | |
0050729 | |
2001244 | |
0002793 | |
0051493 | |
0045471 | |
0032496 | |
0010043 | |
0032119 | |
0002224 | |
0042060 | |
0062023 | |
0005856 | |
0005829 | |
0070062 | |
0005576 | |
0005615 | |
0045111 | |
0005634 | |
0005886 | |
0034774 | |
0016209 | |
0046872 | |
0006935 | |
0002376 | |
0050727 | |
0005737 | |
0016020 | |
0098869 | |
0006917 | |
0005515 |
KEGG ID | hsa:6279 |
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mmu:20201 | |
rno:116547 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 3 39.9 cM |
---|---|
3 43.6 cM |
OMIM ID | 123885 |
---|
Rat chromosome position | 2q34 |
---|
Hugo ID | 10498 |
---|---|
HGNC:10498 |
Human chromosome position | 1q21.3 |
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1q21 |
Swiss-Prot Accession | P05109 |
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P05109.1 | |
P27005 | |
Q53X15 | |
P27005.3 | |
P50115 | |
P50115.3 | |
A8K5L3 | |
D3DV37 | |
Q5SY70 | |
Q9UC84 | |
Q9UC92 | |
Q9UCJ0 | |
Q9UCM6 | |
P31724 |
PIR ID | A31848 |
---|---|
I56163 | |
JN0685 |
Swiss-Prot ID | S10A8_HUMAN |
---|---|
S10A8_MOUSE | |
S10A8_RAT |
Cell Localization | Secreted |
---|---|
Cytoplasm | |
Cytoskeleton | |
Cell membrane | |
Cytoplasm, cytoskeleton |
Ensembl ID | ENSG00000143546 |
---|---|
ENSP00000357721.1 | |
ENST00000368732.5 | |
ENSP00000357722.3 | |
ENST00000368733.4 | |
ENSMUSG00000056054 | |
ENSMUSP00000064385.8 | |
ENSMUST00000069927.9 | |
ENSRNOG00000011557 | |
ENSRNOP00000015473.1 | |
ENSRNOT00000015473.3 | |
ENSRNOT00000015473 | |
ENSMUST00000069927 | |
ENSP00000357722 | |
ENST00000368733.3 | |
ENSMUSP00000064385 | |
ENSRNOP00000015473 | |
ENST00000368733 |
MGI ID | MGI:88244 |
---|---|
88244 |
RGD ID | 620265 |
---|
Unigene ID | Mm.21567 |
---|---|
Hs.416073 | |
Rn.31839 |
Homologene ID | 2225 |
---|
IPI ID | IPI00230768 |
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IPI00007047 | |
IPI00231370 |