Protein IFNGR1

URN urn:agi-llid:3459
Total Entities 0
Connectivity 593
Name IFNGR1
Description interferon gamma receptor 1
Notes This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway Natural Killer Cell Activation
T-Cell Cytotoxic Mediated Cell Death
Th1-Cell Differentiation
Proplatelet Maturation
Macrophage M1 Lineage
AHR Signaling in M1 Macrophages Function
Proteins Involved in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Th1-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Nitric Oxide Effects on beta-Cell
Hashimoto's Thyroiditis
CD4+T-Cell Response in Celiac Disease
Metastatic Colorectal Cancer
Th1-Cell Activation in Crohn's Disease
Keratinocyte Activation in Psoriatic Arthritis
IFNG -> ARRB1/STAT1 Signaling
CSF2 -> NF-kB Expression Targets
Clozapine Induced Granulocytopenia
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
IFNG/IFNR Expression Targets
Ras-GAP Regulation Signaling
TNF -> NF-kB Expression Targets
IL1B Expression Targets
PPAR Psoriasis
IFN signaling in alveolar cells
1_Differentiation of psoriatic T cells
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
Differentiation of psoriatic T cells

Group Genes Associated with Systemic Lupus Erythematosus

MedScan ID 3459

LocusLink ID 3459
15979
116465

Alias Ifgr
RP3-503F13.3
OTTHUMP00000017286
OTTHUMP00000017285
Nktar
IFN gamma R1
CDw119
interferon gamma receptor 1
IFNGR1 receptor
antiviral protein type 2
IFN gamma receptor 1
CD119
INGR_HUMAN
IFNGR1
IFN-gamma-R-alpha
interferon gamma receptor I
receptor IFNGR1
IFNGR I
CD119 antigen
FLJ45734
Interferon-gamma receptor alpha chain
IFN gamma receptor I
immune interferon receptor 1
AVP2
gamma interferon receptor 1
LOC360301
IFNGR
IMD27A
IMD27B
AVP, type 2
IFN-gamma receptor 1
IFN-gamma-R1
antiviral protein, type 2
IFN-gammaR
INF-g receptor
interferon gamma receptor alpha-chain
Immune interferon receptors
interferon-gamma receptor 1
INGR
receptor for immune interferon
ifn-gamma r
INF-g receptors
interferon gamma receptor

GO ID 0019955
0004896
0004906
0048143
0019221
0060333
0001774
1900222
1902004
0010628
1904469
0060334
0009615
0007165
0005887
0005886
0051607
1904783
0030425
0005783
0016021
0016020
0014069
0031982
0042015
0004872

KEGG ID hsa:3459
mmu:15979
rno:116465

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 10 8.49 cM
10 15.0 cM

OMIM ID 107470
209950
600263
610424
615978
607948

Rat chromosome position 1p12

Hugo ID 5439
HGNC:5439

Human chromosome position 6q23.3

Swiss-Prot Accession A0A0S2Z3Y2
P15260
P15260.1
P15261
P15261.3
Q9QZ62
B4DFT7
E1P587
Q53Y96
Q91Y85
F5H5M7
Q14936
Q53GX8
Q5TFD1
Q7Z687
Q9BY69
Q3TW49
Q3U8T2
Q540M5
P70599
Q6P6T3

PIR ID A31555
A34368

GenBank ID NC_000006
XM_011535793
XP_011534095
NM_000416
NP_000407
NM_001363526
NP_001350455
NM_001363527
NP_001350456
XM_006715470
XP_006715533
XM_011535794
XP_011534096
NG_007394
AH006710
AAC52064
AJ490331
CAD35933
AJ490332
CAD35932
AL050337
AY594694
AAS89302
CH471051
EAW47931
EAW47932
HQ670233
ADR72811
HQ670234
ADR72812
HQ670235
ADR72813
HQ670236
ADR72814
HQ670237
ADR72815
AF056979
AAK30623
AK127636
AK222803
BAD96523
AK294252
BAG57548
AK297052
BAG59578
AK312674
BAG35556
BC005333
AAH05333
BT006814
AAP35460
BU674317
DC349115
EF173879
ABM53152
EF535103
ABQ00413
J03143
AAA52731
KU178144
ALQ33602
KU178145
ALQ33603
P15260
NC_000076
NM_010511
NP_034641
AC153862
CH466562
EDL03452
U05960
AAA80980
AF128216
AAF22557
AF128217
AAF22558
AK087525
AK150503
BAE29616
AK151079
BAE30094
AK152085
BAE30935
AK152384
BAE31172
AK153084
BAE31709
AK153347
BAE31923
AK159359
BAE35017
AK159660
BAE35269
AK159839
BAE35417
AK169593
BAE41245
AY157836
AAO21311
AY157837
AAO21312
BC132599
AAI32600
BC138617
AAI38618
BU700524
BY309097
BY754033
J05265
AAA39178
M25764
AAA39177
M26711
AAA37896
M28233
AAA37898
M28995
AAA37895
P15261
NC_005100
NM_053783
NP_446235
AC_000069
AAHX01001705
AC116231
CH473994
EDL93784
AF201901
AAF08977
BC062039
AAH62039
U68272
AAB17055
XP_006715534
XM_006715471
XP_016866316
XM_017010827
U19247
AAHY01083833
ABBA01025818
XP_005267015
U19242
U19241
U19244
U19243
U19246
U19245
XP_005267016
AABR06000779
AC_000032
AC_000138
XM_005266959
XM_005266958
AMYH02014569
AMYH02014568
NC_018917
CAB53062
CAI21592
CAI21593
NT_025741
NW_001838990
NW_923184
AC_000049
CR594485
CR601864
CR624388
CR625186
Q14936
Q53GX8
Q5TFD1
Q7Z687
Q9BY69
NT_039492
NW_001030408
Q3TW49
Q3U8T2
Q540M5
Q91Y85
NW_001084746
NW_047544
P70599
Q6P6T3
Q9QZ62

Swiss-Prot ID INGR1_HUMAN
INGR1_MOUSE
Q91Y85_MOUSE
Q9QZ62_RAT
Q53Y96_HUMAN

Cell Localization Cell membrane
Membrane
Plasma membrane

Ensembl ID ENSG00000027697
ENSP00000356713.4
ENST00000367739.8
ENSP00000494069.1
ENST00000646898.1
ENSMUSG00000020009
ENSMUSP00000020188.6
ENSMUST00000020188.12
ENSRNOG00000012074
ENSRNOP00000016286.4
ENSRNOT00000016286.6
ENST00000646036.1
ENST00000644894.1
ENSP00000496387.1
ENSP00000495272.1
ENSRNOP00000016286
ENSMUST00000020188
ENSRNOT00000016286
ENSP00000443282
ENSP00000356713
ENST00000543628
ENST00000367739
ENSMUSP00000020188

MGI ID MGI:107655
107655

RGD ID 620570

Unigene ID Mm.549
Hs.520414
Rn.19927

Homologene ID 359

Shape Stick-vertex

IPI ID IPI00323231
IPI00010808
IPI00129679
IPI00327970
IPI00514230
IPI00514426