Protein PTPN11

URN urn:agi-llid:4903
Total Entities 0
Connectivity 3387
Name PTPN11
Description protein tyrosine phosphatase, non-receptor type 11
Notes The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Primary Cell Localization Cytoplasm
Class Protein phosphatase

Pathway Leptin and CCK8 Activate Nodose Ganglia Neuron
Natural Killer Cell Inhibitory Receptor Signaling
Peripheral T-Cell Tolerance
Do not Eat me\xc2\x9d Signal: Viable Cells Inhibits Phagocytosis
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
IL6 Expression Targets -> Nociception
Proteins Involved in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
IL22 Induces Keratinocyte Proliferation in Psoriasis
Insulin Resistance in Hepatocytes
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Immune System Activation in Hyperthyroidism
Proteins Involved in Helicobacter Infections
CagA Phosphorylation Dependent Signaling
Proteins Involved in Acute Myeloid Leukemia
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
IL6 Promotes Inflammation in Muscular Dystrophies
Leptin Role in Endometriosis
Noreadrenaline/Gq Expression Targets
Epinephrine/Gq Expression Targets
SELE -> ELK-SRF Signaling
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
Effector T-cell Inactivation in Cancer Immune Escape
PECAM -> SP1 Signaling
IL6R -> CEBP/ELK/SRF Signaling
IL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
LPA Expression Targets
AGT -> TP53 Expression Targets
AGT -> CREB Expression Targets
AGT -> ELK/SRF Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
AXL Receptor Tyrosine Kinase Signaling
ROS and RNS in Vasoconstriction and Vasodilation Regulation
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
sialic
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_Defective tolerance of autoreactive T-cell in T1D
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Acute Myeloid Leukemia
Genes Associated with Syndromic Epilepsy

MedScan ID 4903

LocusLink ID 4903
5781
19247
25622

Alias Src homology phosphatase-2
phosphotyrosine phosphatase 1D
protein tyrosine phosphatase SH-PTP2
RIKEN cDNA 2700084A17 gene
protein tyrosine phosphatase-2
protein tyrosine phosphatase, nonreceptor type 11 isoform II
Src homology region phosphatase SHP2
Src homology phosphatase SHP2
protein tyrosine phosphatase, non receptor type 11
PTNB_HUMAN
phosphatase SHP2
Noonan syndrome 1 gene
Src homology region 2 domain-containing phosphatase 2
OTTMUSP00000017430
Src homology region 2 domain-containing protein tyrosine phosphatase SHP-2
protein-tyrosine phosphatase SYP
SH2 domain-containing protein tyrosine phosphatase-2
protein tyrosine phosphatase, nonreceptor type 11 (Noonan syndrome 1)
protein tyrosine phosphatase, non receptor type 11 (Noonan syndrome 1)
SH2 domain-containing protein tyrosine phosphatase II
Noonan syndrome 1 protein
SH-PTP2
BPTP3
SHP2
protein tyrosine phosphatase, nonreceptor type 11 isoform 1
Src homology region phosphotyrosyl phosphatase SHP2
nonreceptor protein tyrosine phosphatase 11
protein tyrosine phosphatase, non receptor type 11 isoform 1
Src homology region domain 2 containing protein phosphatase 2
protein tyrosine phosphatase, non receptor type 11 isoform 2
non receptor protein tyrosine phosphatase 11
NS I
protein tyrosine phosphatase SHP2
PTP1D
tyrosine phosphatase 2C
SHPTP2
SHP2/pp75
MGC14433
protein tyrosine phosphatase, nonreceptor type 11 isoform I
Src homology phosphotyrosyl phosphatase SHP2
Src homology 2 domain protein tyrosine phosphatase SHP-2
SH-PTP3
protein tyrosine phosphatase, non receptor type 11 isoform II
Src homology 2 domain-containing protein tyrosine phosphatase SHP-2
METCDS
SHP2 phosphatase
SH-PTP2 protein tyrosine phosphatase nonreceptor type 11
2700084A17
Noonan syndrome I gene
protein tyrosine phosphatase, nonreceptor type 11 isoform 2
protein-tyrosine phosphatase 1D
AW536184
Src homology region phosphatase-2
PTP2C
PRO1847
Src homology domain 2 containing protein phosphatase 2
SH2 domain-containing protein tyrosine phosphatase SHP-2
PTNB
PTPN11
2700084A17Rik
OTTHUMP00000166108
Noonan syndrome I protein
protein-tyrosine-phosphatase, nonreceptor type 11
Src homology region 2 domain protein tyrosine phosphatase SHP-2
protein tyrosine phosphatase, non receptor type 11 isoform I
SH-PTP2 protein tyrosine phosphatase non receptor type 11
CFC
NS1
JMML
PTP-1D
PTP-2C
protein-tyrosine phosphatase 2C
tyrosine-protein phosphatase non-receptor type 11
Syp
SAP-2
SHP-2
SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
encodes catalytic domain
SH-PTP2 protein tyrosine phosphatase non-receptor type 11
null
protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
protein tyrosine phosphatase, non-receptor type 11 isoform I
protein tyrosine phosphatase, non-receptor type 11 isoform 2
protein tyrosine phosphatase, non-receptor type 11
protein tyrosine phosphatase, non-receptor type 11 isoform 1
protein tyrosine phosphatase, non-receptor type 11 isoform II

EC Number 3.1.3.48

GO ID 0031748
0005070
0050839
0005158
0043560
0004726
0051428
0043274
0004721
0001784
0019904
0019901
0004725
0030971
0060020
0000077
0038127
0031295
0033277
0000187
0036302
0007411
0007420
0071345
0071364
0071260
0021697
0019221
0048013
0007173
0060325
0008543
0048806
0042593
0007507
0048873
0042445
0009755
0048839
0007229
0070102
0061582
0050900
0035855
0032528
0035264
0048609
0033629
0051463
0060125
0046676
0048011
0035265
0035335
0030168
0030220
0048008
0070374
0046326
0046887
0046628
0032728
0032755
0045931
0050731
0051897
0032760
0033628
0043254
0046825
0060338
0006641
0005737
0005829
0005739
0005654
0005634
0032991
0016787
0016791
1990782
0007409
0016311
0006629
0046888
0009967
0006470
0030054
0016020
0001725
0040014
0016303
0046934
0046854
0036092
0048015
2001275
0014066
0043234
0038095
0007596
0045087
0008286
0060333
0060334
0060337

KEGG ID hsa:5781
mmu:19247
rno:25622

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 5

OMIM ID 176876
607785
151100
156250
163950

Rat chromosome position 12q16

Hugo ID 9644
HGNC:9644

Human chromosome position 12q24.13
12q24

Swiss-Prot Accession Q06124
Q06124.2
P35235
P35235.2
P41499
P41499.4
A8K1D9
Q96HD7
Q3TQ84
Q64509
Q6PCL5
Q62626

PIR ID JN0805
A46209
A53593

GenBank ID NC_000012
NM_001330437
NP_001317366
NM_002834
NP_002825
XM_017019722
XP_016875211
XM_011538613
XP_011536915
NM_080601
NP_542168
NG_007459
AC004086
AC004216
CH471054
EAW98011
EAW98012
AK289854
BAF82543
AK312147
BAG35082
AU123593
BC007869
BC008692
AAH08692
BC025181
AAH25181
BC030949
AAH30949
BF515187
BQ007989
BT007106
AAP35770
BX537632
CN258646
D13540
BAA02740
DA498964
DB450422
EU779706
ACE60554
EU779707
ACE60555
EU779708
ACE60556
L03535
AAA36611
L07527
AAA17022
L08807
S39383
S78088
AAB21148
U79291
X70766
CAA50045
Q06124
NC_000071
NM_001109992
NP_001103462
NM_011202
NP_035332
AC110037
AC127553
CH466529
EDL19739
AK011468
BAB27639
AK012560
AK135991
AK147354
AK159501
BAE35134
AK159587
BAE35207
AK163809
BAE37500
BC003980
BC028513
AAH28513
BC057398
AAH57398
BC059278
AAH59278
BM899214
CF751511
D84372
BAA12328
S59187
AAB26343
P35235
NC_005111
NM_001177593
NP_001171064
NM_013088
NP_037220
AC_000080
AABR07036375
AABR07036376
AAHX01072549
AAHX01072550
CH473973
EDM13752
D83016
BAA74951
U05963
AAA19133
U09307
AAA20543
U57499
AAB02229
P41499
XM_006719526
XP_006719589
XM_006719527
XP_006719590
NC_018923
AMYH02027223
AMYH02027224
AC_000027
AAHY01048914
AAHY01048915
AAHY01048916
AAHY01048917
AAHY01048918
AAHY01048919
AC_000144
ABBA01019934
ABBA01019935
ABBA01019936
ABBA01019937

Swiss-Prot ID PTN11_HUMAN
PTN11_MOUSE
PTN11_RAT

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000179295
ENSP00000489597.1
ENST00000635625.1
ENSP00000340944.2
ENST00000351677.6
ENSP00000376376.1
ENST00000392597.5
ENSMUSG00000043733
ENSMUSP00000098333.2
ENSMUST00000100770.8
ENSMUSP00000058757.7
ENSMUST00000054547.8
ENSRNOG00000030124
ENSRNOP00000041842.5
ENSRNOT00000046323.5
ENSP00000340944
ENST00000351677
ENSP00000376376
ENST00000392597
ENSP00000489597
ENST00000635625
ENSMUSP00000098333
ENSMUST00000100770
ENSMUSP00000058757
ENSMUST00000054547
ENSRNOP00000041842
ENSRNOT00000046323

MGI ID MGI:99511

RGD ID 3447

Unigene ID Hs.506852
Mm.8681
Rn.98209

Homologene ID 2122

Shape 2Triangles