URN | urn:agi-llid:3661 |
---|---|
Total Entities | 0 |
Connectivity | 2133 |
Name | IRF3 |
Description | interferon regulatory factor 3 |
Notes | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
Primary Cell Localization | Nucleus |
Class | Transcription factor |
ObjectType | Protein |
Pathway | Cortisol in Resolving Inflammation |
---|---|
Antiviral Signaling through Pattern Recognition Receptors | |
TLR4 Signaling in Leukocytes | |
Toll-like Receptors in Sterile Inflammation | |
Macrophage M1 Lineage | |
AXL Receptor Inhibits Macrophages and Dendritic Cells Function | |
Dendritic Cells Function in Atherosclerosis | |
MAVS in Antiviral Innate Immune Response in Myocarditis | |
Proteins Involved in Myocarditis | |
Dendritic Cells Function in Psoriasis | |
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus | |
Dendritic Cell Activation in Systemic Lupus Erythematosis | |
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus | |
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1 | |
Crohn's Disease | |
Dendritic Cell Dysfunction in Crohn's disease | |
Dendritic Cell Function in Ulcerative Colitis | |
Airway Epithelial Cell Dysfunction | |
Toll-like Receptors (TLR) in Periodontitis | |
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes | |
TLR3 Role in Retinal Pigment Epithelial Cell | |
Alveolar Macrophages Dysfunction in COPD | |
IL15 Expression Targets | |
TLR3 Expression Targets | |
TLR4 -> NF-kB/IRF Expression Targets | |
TLR4 -> IRF Signaling | |
TLR3 -> IRF Signaling | |
pathway 4 | |
New Pathway (2) | |
Model of PPARG signaling in psoriasis | |
PPARG negative regulators and targets | |
Model of PPARG related pathways in psoriasis (short version) | |
sars-cov binding | |
sars-cov no binding | |
dsRNA induces innate immunity and INFs in alveolar cells | |
AGER feed forward loop in innate immunity | |
Dendritic Cell Activation in COVID19 | |
Overview. Diseases of the genitourinary system (chapter 13) | |
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media | |
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease | |
2_Intestine epithelial cells drive immunological responses in ulcerative colitis | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D |
Group | Genes Associated with Systemic Lupus Erythematosus |
---|---|
binding partnetrs for SARSs | |
other partners for SARS |
MedScan ID | 3661 |
---|
LocusLink ID | 3661 |
---|---|
54131 | |
292892 |
Alias | C920001K05Rik |
---|---|
OTTMUSP00000022257 | |
IRF III | |
interferon regulatory factor 3 | |
IRF-3 | |
IIAE7 | |
OTTMUSP00000022256 | |
IRF IIIs | |
C920001K05 | |
interferon regulatory factor III | |
OTTMUSP00000022258 | |
RIKEN cDNA C920001K05 gene | |
MGC94729 | |
MGC91046 |
GO ID | 0003677 |
---|---|
0001228 | |
0000981 | |
0001227 | |
0000978 | |
0019904 | |
0042803 | |
0043565 | |
0003712 | |
0039530 | |
0035666 | |
0006915 | |
0006974 | |
0071360 | |
0051607 | |
0002376 | |
0060333 | |
0031663 | |
0071888 | |
0000122 | |
0032480 | |
0043123 | |
0050715 | |
0032727 | |
0032728 | |
0045944 | |
0032481 | |
0060340 | |
0097300 | |
0050727 | |
0032479 | |
0006366 | |
0045351 | |
0060337 | |
0016032 | |
0005737 | |
0005829 | |
0005654 | |
0005634 | |
0003700 | |
0044212 | |
0071222 | |
0045087 | |
0050689 | |
0045358 | |
0045893 | |
0010468 | |
0006355 | |
0009617 | |
0043330 | |
0032496 | |
0006917 | |
0034142 | |
0006351 | |
0000975 | |
0002756 | |
0001077 | |
0005515 | |
0019221 | |
0034138 | |
0008063 | |
0001078 | |
0071359 | |
0010008 | |
0019048 | |
0042802 | |
0002224 | |
0003702 | |
0044419 | |
0009615 | |
0005886 | |
0010843 | |
0010553 |
KEGG ID | hsa:3661 |
---|---|
mmu:54131 | |
rno:292892 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 7 |
---|
OMIM ID | 603734 |
---|---|
616532 |
Rat chromosome position | 1q22 |
---|
Hugo ID | 6118 |
---|---|
HGNC:6118 |
Human chromosome position | 19q13.33 |
---|---|
19q13.3-q13.4 |
Swiss-Prot Accession | Q14653 |
---|---|
E2GIM5 | |
E2GIM7 | |
E2GIM8 | |
E2GIM9 | |
M0QYT9 | |
E2GIM6 | |
Q14653.1 | |
P70671 | |
Q3U9K6 | |
P70671.1 | |
Q5XIB0 | |
A8K7L2 | |
B2RAZ3 | |
Q5FBY1 | |
Q5FBY2 | |
Q5FBY4 | |
Q7Z5G6 | |
Q71U93 | |
Q96GL3 | |
O54726 | |
Q3UJM9 |
Swiss-Prot ID | IRF3_HUMAN |
---|---|
IRF3_MOUSE | |
E2GIM8_HUMAN | |
Q7Z5G6_HUMAN | |
Q3U9K6_MOUSE | |
E2GIM7_HUMAN | |
E2GIM6_HUMAN | |
Q5XIB0_RAT | |
E2GIM5_HUMAN | |
E2GIM9_HUMAN | |
Q5FBY2_HUMAN | |
Q5FBY1_HUMAN |
Cell Localization | Cytoplasm |
---|---|
Nucleus |
Ensembl ID | ENSG00000126456 |
---|---|
ENSP00000471896.1 | |
ENST00000601291.5 | |
ENSP00000471358.1 | |
ENST00000599223.5 | |
ENSP00000366339.5 | |
ENST00000377135.8 | |
ENSP00000470069.1 | |
ENST00000599144.5 | |
ENSP00000472700.1 | |
ENST00000600022.5 | |
ENSP00000470512.1 | |
ENST00000596765.5 | |
ENSP00000366344.3 | |
ENST00000377139.8 | |
ENSP00000310127.6 | |
ENST00000309877.11 | |
ENSP00000470431.1 | |
ENST00000600911.5 | |
ENSP00000469113.1 | |
ENST00000597198.5 | |
ENSP00000472582.1 | |
ENST00000598808.5 | |
ENSMUSG00000003184 | |
ENSMUSP00000003284.8 | |
ENSMUST00000003284.15 | |
ENSMUSP00000146773.1 | |
ENSMUST00000209066.1 | |
ENSMUSP00000103465.1 | |
ENSMUST00000107834.1 | |
ENSRNOG00000043388 | |
ENSRNOP00000027786.4 | |
ENSRNOT00000027786.6 | |
ENST00000596765 | |
ENSRNOP00000027786 | |
ENSMUSP00000003284 | |
ENST00000600022 | |
ENSP00000471358 | |
ENSP00000472601 | |
ENSP00000470069 | |
ENSMUST00000107835 | |
ENSMUST00000107834 | |
ENSP00000366344 | |
ENSMUSP00000103466 | |
ENSMUSP00000103465 | |
ENST00000377135 | |
ENST00000597636 | |
ENSP00000472582 | |
ENST00000377139 | |
ENSRNOT00000027786 | |
ENSMUST00000003284 | |
ENST00000598808 | |
ENSP00000472700 | |
ENSP00000471896 | |
ENSP00000366339 | |
ENST00000309877 | |
ENST00000377139.7 | |
ENST00000601291 | |
ENSMUST00000209066 | |
ENST00000599144 | |
ENSP00000310127 | |
ENST00000599223 | |
ENSMUSP00000146773 | |
ENST00000593922 | |
ENSP00000470512 |
MGI ID | MGI:1859179 |
---|---|
1859179 |
RGD ID | 1549774 |
---|
Unigene ID | Hs.75254 |
---|---|
Hs.731922 | |
Mm.489648 | |
Rn.1499 | |
Hs.289052 | |
Mm.3960 |
Homologene ID | 1208 |
---|
Shape | O-vertex |
---|
IPI ID | IPI00111836 |
---|---|
IPI00291901 | |
IPI00737251 | |
IPI00646709 | |
IPI00976695 | |
IPI00364320 | |
IPI00941119 | |
IPI00873861 |