Protein GRB2

URN urn:agi-llid:2885
Total Entities 0
Connectivity 2107
Name GRB2
Description growth factor receptor-bound protein 2
Notes The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm

Pathway Alzheimer's Disease
Osteoarthritis
Skin Aging
mTOR Signaling
mTOR Signaling Hyperfunction
Insulin Influence on Protein Synthesis
Insulin Influence on Glycogenesis
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Insulin Signaling
Prolactin Production
Thrombopoietin Receptors Signaling in Platelet Maturation
T-Cell Dependent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
Peripheral T-Cell Tolerance
T-Cell Positive Selection and Neglect Induced Death
T-Cell Central Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Growth Factors
Dendritic Spine Morphogenesis and Stabilization
Nociception Expression Targets Signaling
NTSR1 Expression Targets
DRD2 Expression Targets
DRD2 -> TRPC1 Transcription
CHRM1 -> IL2 Production
IL6 Expression Targets -> Nociception
CHRNA7 -> NOS1 Production
Vitamine D Deficite and Dentin Formation
Th1-Cells Activation and Proliferation in Atherosclerosis
Arterial Hypertension
Endothelial Cell Dysfunction in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Lymphocyte Mediated Myocardial Injury in Myocarditis
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Hyperseborrhea in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Androgens in Sebocyte Maturation
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
RET1 Mutation in Hyperparathyroidism
Cardiovascular Effects in Hyperthyroidism
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
Cetuximab Resistance in Colorectal Cancer
Metastatic Colorectal Cancer
CagA Phosphorylation Independent Signaling
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Follicular Lymphoma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Exocytosis in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Cowden Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Rett Syndrome
IL6 Promotes Inflammation in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
Osteoblast Function Decline in Osteoporosis
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Glioma Invasion Signaling
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Leptin Role in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
Prostate Cancer
Steroids Induced Cataract
Glutamate Mediated Excitotoxicity in Glaucoma
Cytokines Trigger Otitis Media
Mucin Hyperproduction in Goblet and Mucous Cells
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
AREG -> FOXO3A Expression Target
Noreadrenaline/Gq Expression Targets
Acetylcholine Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
SELE -> ELK-SRF Signaling
CD247 Expression Targets
FCGR3A Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CHRNA7 -> CREB Signaling
Tamoxifen Induced Endometrial Cancer
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> FOXO3A Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> FOXO3A Expression Target
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> FOXO3A Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> FOXO3A Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF10 -> FOXO3A Expression Target
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FPR1 -> Cytoskeleton Signaling
Glutamate/Gq Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
TGFB Signaling activation by Blocking of Tumor Suppressors
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Invadopodia Formation in Cancer Cells
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
NCAM1 -> CREB/ELK/SRF/MYC Signaling
PECAM -> SP1 Signaling
FcIgER -> ELK-SRF Signaling
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
InsulinR -> ELK/SRF/SREBF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
IL6R -> CEBP/ELK/SRF Signaling
IL2R -> ELK/SRF/MYC Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL16 -> AP-1 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
LPA Expression Targets
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> FOXO3A Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
NTS Expression Targets
AGT -> TP53 Expression Targets
AGT -> CREB Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AGT -> ELK/SRF Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
GDNF -> HSF1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Ras-GRF Regulation Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
MERTK Signaling
TGF-beta Signaling
AXL Receptor Tyrosine Kinase Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
ERK/MAPK Canonical Signaling
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
T-Cell Receptor -> NF-kB Signaling
T-Cell Receptor -> NFATC Signaling
T-Cell Receptor -> CREBBP Signaling
TGFA -> FOXO3A Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
LTA Expression Targets
TNF -> AP-1 Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> SPI1 Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
New Pathway
1_Inflammation in keratinocytes in the pathology of acne
3_Increased proliferation of sebocytes in acne vulgaris
2_Hyperseborrhea in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Osteoblast-mediated bone demineralization
3_The role of interstitial fibroblasts in pyelonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
2_Pathogens stimulate mucins expression in the middle ear
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
1_2_Insulin synthesis and secretion: insulin secretion
1_1_Insulin synthesis and secretion: insulin processing and storage
4_2_Insulin resistance: inflammation-related insulin resistance
4_1_Insulin resistance: insulin signaling
3_Islet beta-cell destruction in T1D
2_1_General pathways of thyroid hormone signaling
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Cowden Syndrome

MedScan ID 2885

LocusLink ID 2885
14784
81504

Alias OTTMUSP00000003660
OTTHUMP00000166096
SH2/SH3 adaptor GRB2
HT027
FLJ20886
GRB2_HUMAN
AA408164
OTTHUMP00000166098
EGFRBP-GRB2
abundant SRC homology
OTTMUSP00000003662
GRB2 adaptor protein
OTTHUMP00000166097
Grb2
OTTMUSP00000003663
Growth factor receptor-bound protein II
growth factor receptor bound protein 2
RP23-28I4.1
NCKAP2
epidermal growth factor receptor-binding protein GRB2
HT(027)
MST084
MGC108668
Grb3 III
growth factor receptor-bound protein 3
adaptor protein GRB2
OTTMUSP00000003661
Grb3-3
MSTP084
ASH
SH2/SH3 adapter GRB2
epididymis secretory sperm binding protein
protein Ash
growth factor receptor-bound protein 2
adapter protein GRB2
Ash-psi
GRB2 adapter protein

GO ID 0003723
0017124
0005070
0046875
0005154
0043560
0005168
0001784
0019901
0019903
0038128
0038095
0038096
0000165
0007265
0031295
0007568
0048646
0007411
0060670
0007267
0071479
0019221
0035635
0007173
0008543
0008286
0035723
0050900
0061024
0042059
0048011
0046579
0030838
0051897
2000379
0051291
0031623
0043408
0042770
0016032
0008180
0005794
0070436
0005911
0005737
0005829
0005768
0070062
0005730
0005654
0005634
0005886
0012506
0019899
0051219
0019904
0030154
0016020
0032991
0009967
0016303
0005088
0046934
0044822
0046854
0036092
0048015
0043547
0014066
0043234
0007596
0045087
0030168
0005622
0019048
0034329
0044419
0004872
0007165

KEGG ID hsa:2885
mmu:14784
rno:81504

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 11 80.91 cM
11 75.0 cM

OMIM ID 108355

Rat chromosome position 10q32.1
10q32.3

Hugo ID 4566
HGNC:4566

Human chromosome position 17q25.1
17q24-q25

Swiss-Prot Accession B0LPF3
P62993
P62993.1
Q3U1Q4
Q3U5I5
Q60631
Q60631.1
P62994
P62994.1
P29354
Q14450
Q63057
Q63059
Q61240
Q5BKA7
Q6ICN0
Q63058

PIR ID A43321
A54688
S26050

GenBank ID NC_000017
NM_203506
NP_987102
NM_002086
NP_002077
NG_029556
AC011933
AH006977
AAC72075
CH471099
EAW89270
EAW89271
EAW89272
EU332843
ABY87532
JX512444
AGC09591
AA452034
AF171699
AAQ13606
AF246238
AAG44485
AF302079
AAG27442
AF498925
AAM21073
AK024539
BAB14923
AK091010
BAG52262
AK315565
BAG37940
BC000631
AAH00631
BC019082
BC033644
BC039827
BC043007
BI459414
BQ073225
BQ962129
CR450363
CAG29359
CR541942
CAG46740
DA458680
GQ901029
ADO22546
L29511
AAC37549
M96995
AAA58448
X62852
CAA44664
P62993
NC_000077
NM_008163
NP_032189
NM_001313936
NP_001300865
NM_001313937
NP_001300866
AL645852
AL732491
CH466558
EDL34515
EDL34516
EDL34517
AK077750
AK079087
AK148148
BAE28376
AK153557
BAE32093
AK155800
BAE33439
AK166142
BAE38595
AK170845
BAE42068
AK172002
AK177056
AK180406
AK181485
AK184348
AK192421
AK192819
AK194267
AK195178
AK195957
AK196023
AK196107
AK196759
AK202005
AK208766
AK211391
AK212651
AK215138
AK216513
AK217191
AK217799
BC052377
AAH52377
BC085254
AAH85254
BQ174314
BY266228
BY292622
D85748
BAA12862
U07617
AAB40022
Q60631
NC_005109
NM_030846
NP_110473
AC_000078
AABR07030782
AABR07030783
AABR07030784
AABR07030785
AABR07030786
AAHX01066734
AAHX01066735
AAHX01066736
CH473948
EDM06604
EDM06605
EDM06606
EDM06607
EDM06608
EDM06609
EDM06610
AA926364
BC091144
AAH91144
D49846
BAA08645
D49847
BAA08646
D49848
BAA08647
FQ220840
FQ229940
X62853
CAA44665
P62994
NC_018928
AF063614
AF063615
AF063616
AF063617
AF063618
AMYH02033991
AMYH02033992
AMYH02033993
AMYH02033994
AMYH02033995
DQ891830
ABM82756
DQ894923
ABM85849
AC_000033
AAHY01096670
AAHY01096671
AAHY01096672
AC_000149
ABBA01028798
ABBA01028799
ABBA01028800
ABBA01028801
XM_006247767
XP_006247829
AABR06066174
AABR06066175
AABR06066176
AABR06066177
AABR06066215
CAM21965
CAM21966
CAM21967
CAM21968
CAM19836
CAM19837
CAM19838
CAM19839
XM_003750955
XP_003751003
XM_003750956
XP_003751004
NT_010783
NW_001838454
NW_926918
AC_000060
BC009417
Q6ICN0
NT_165773
NW_001030434
Q3U1Q4
Q3U5I5
NW_047343
NW_001084656
Q63058

Swiss-Prot ID GRB2_HUMAN
GRB2_MOUSE
GRB2_RAT
B0LPF3_HUMAN
Q3U5I5_MOUSE

Cell Localization Nucleus
Cytoplasm
Endosome
Golgi apparatus

Ensembl ID ENSG00000177885
ENSP00000339007.4
ENST00000316804.10
ENSP00000317360.5
ENST00000316615.9
ENSMUSG00000059923
ENSMUSP00000102106.1
ENSMUST00000106497.7
ENSMUSP00000021090.7
ENSMUST00000021090.13
ENSRNOG00000003990
ENSRNOP00000005347.4
ENSRNOT00000005347.5
ENSP00000339007
ENST00000316804
ENSP00000317360
ENST00000316615
ENSMUSP00000021090
ENSMUST00000021090
ENSRNOP00000005347
ENSRNOT00000005347

MGI ID MGI:95805
95805

RGD ID 619758

Unigene ID Hs.444356
Mm.439649
Mm.490413
Rn.3360
Hs.708119
Mm.472452

Homologene ID 1576

IPI ID IPI00021327
IPI00218070
IPI00203630
IPI00231574
IPI00382077
IPI00119058
IPI00230539
IPI00018782
IPI00790124
IPI00792746
IPI00648993
IPI00649256
IPI00204921
IPI00567134