Pathway
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Alzheimer's Disease
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Osteoarthritis
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Skin Aging
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MTHFR Activity Regulation
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mTOR Signaling Hyperfunction
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TLR4 Signaling in Leukocytes
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Peripheral T-Cell Tolerance
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T-Cell Cytotoxic Mediated Cell Death
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Necrosis
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Leukotriene Effect on Vascular Endothelial Cell Response
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Eosinophil Survival by Cytokine Signaling
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Macrophage M1 Lineage
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Neutrophil Recruitment and Priming
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Negative Acute Phase Proteins Synthesis
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Positive Acute Phase Proteins Synthesis
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Vascular Endothelial Cell Activation by Cytokines
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Adipokines Production by Adipocyte
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Lipolysis Regulation in Adipocyte
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Apoptosis
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Proteins Involved in Atherosclerosis
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Dilated Cardiomyopathy
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Cardiomyocyte Hypertrophy
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Hypertrophic Cardiomyopathy
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Myocardial Infarction
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Proteins Involved in Myocarditis
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Apoptosis of Myocyte
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SOCS in Negative Feedback Regulation in Myocarditis
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Inflammatory Reaction in Acne Vulgaris
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Hair Follicle Keratinocyte Apoptosis
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IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
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Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
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Oxidative Stress in Vitiligo
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Vitiligo
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Toll-like Receptors in beta-Cell
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Podocyte Dysfunction in Diabetic Nephropathy
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Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
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Proteins Involved in Insulin Resistance
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Adipose Tissue Inflammation Provokes Insulin Resistance
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Adiponectin Synthesis Declines in Insulin Resistance
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Proteins Involved in non-Alcoholic Fatty Liver Disease
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Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
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beta-Cell Destruction through Cytokines in Diabetes Mellitus
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beta-Cell Destruction in Diabetes Mellitus Type 1
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Adipokines Production by Adipocyte Impaired in Obesity
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Proteins Involved in Obesity
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Crohn's Disease
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Macrophage Dysfunction
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Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
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Mantle Cell Lymphoma
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mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
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Splenic Marginal Zone Lymphoma
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TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
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Multiple Myeloma
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TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
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Goblet-Cell Related Mucus Secretion in Asthma
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Proteins Involved in Cystic Fibrosis
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Airway Epithelial Cell Dysfunction
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Neutrophil Recruitment in Sinovium in Gout
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TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
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Apoptosis of Chondrocyte
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Dendritic Cell Dysfunction in Psoriatic Arthritis
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Synovial Fibroblast Activation in Psoriatic Arthritis
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Keratinocyte Activation in Psoriatic Arthritis
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Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
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Apoptosis Block in Synovial Fibroblast
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Skin Fibrosis
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Dentin and Enamel Dysruprion in Bloch-Sulzberger Syndrome
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Apoptosis Block in Infected Cells
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Diabetes Induced Periodontitis
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IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
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TNF Receptor Associated Periodic Syndrome
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Osteoclast Activation in Postmenopause
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Neurofibrillary Tangle Formation
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Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
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Glioblastoma, Mesenchymal Subtype
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Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
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Proteins Involved in Endometriosis
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Subepithelial Fibroblasts in Middle Ear Cholesteatoma
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HPV Infection and Cancer
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HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
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OPTN Effects on NF-kB Signaling in Glaucoma
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Glutamate Mediated Excitotoxicity in Glaucoma
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Proteins Involved in Otitis Media
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Cytokines Trigger Otitis Media
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Alveolar Epithelial Cell Apoptosis in COPD
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Alveolar Macrophages Dysfunction in COPD
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Mucin Hyperproduction in Goblet and Mucous Cells
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Proteins Involved in Glomerulonephritis
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Podocyte Dysfunction in Glomerulonephritis
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Interstitial Fibroblasts in Pyelonephritis
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Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
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Dopamine/Gs Expression Targets
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Dopamine/Gi Expression Targets
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Elevated Receptors -> Expression Targets in Aorta
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CXCL12 Expression Targets
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FSHR Expression Targets
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NFKB Canonical Signaling Activation in Cancer
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NFKB Non-Canonical Signaling Activation in Cancer
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STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
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NFKB Signaling Activation by Blocking of Tumor Suppressors
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Apoptosis Block by Death Receptor Signaling in Cancer
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Apoptosis Evasion in Cancer: Overview
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Cancer Cells Inhibit Adipocyte Differentiation
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Skeletal Muscle Wasting in Cancer Cachexia
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IDO1 in Cancer Immune Escape
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Effector T-cell Inactivation in Cancer Immune Escape
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IFNG/IFNR Expression Targets
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IL2 Expression Targets
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Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
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CD40 -> Expression Targets in Thymus
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CD40 -> Expression Targets in Lymph Node
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CSF1 -> STAT Expression Targets
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CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
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TNF-alpha/TNFRSF1A Signaling
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Ras-GAP Regulation Signaling
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NF-kB non-Canonical Signaling
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NF-kB Canonical Signaling
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TGFB1-ACVRL1 Expression Targets
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TNF -> NF-kB Expression Targets
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LTA Expression Targets
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TNF -> AP-1 Expression Targets
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TNF -> ELK-SRF Expression Targets
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TNF -> CREB Expression Targets
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TNF -> STAT Expression Targets
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TNF -> TP53/ATF Expression Targets
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TNFRSF1A -> STAT Signaling
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TNFR -> NF-kB Signaling
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TNFRSF1A -> AP-1/ATF/TP53 Signaling
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TNFRSF1A -> CREB/ELK-SRF Signaling
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IL1B -> NO Expression Targets
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TLR4 -> AP-1/EGR1/HIF1A Expression Targets
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IL1B Expression Targets
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IL1A Expression Targets
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Model of PPARG signaling in psoriasis
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1_Inflammation in keratinocytes in the pathology of acne
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1_Differentiation of psoriatic T cells
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1_TNF and IL1B provoke ECM degradation in osteoarthritis
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1_Osteoclast-mediated bone resorption in postmenopausal women
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2_Chondrocyte death in osteoarthritis
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3_The role of interstitial fibroblasts in pyelonephritis
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2_Podocyte dysfunction in glomerulonephritis
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2_Pathogens stimulate mucins expression in the middle ear
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2_Cardiomyocyte hypertrophy
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2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD
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3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
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3_2_Regulation of airway surface liquid (ASL) thickness
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3_1_Mucus accumulation in asthma
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4_Mucin hyperproduction in goblet and mucous cells in COPD
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4_1_Polymorphisms associated with inflammatory bowel diseases
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6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
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5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
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2_HIV - induced depletion of CD4+ T-cells
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4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
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4_2_Insulin resistance: inflammation-related insulin resistance
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2_Ion channel CFTR failure in cystic fibrosis airway epithelium (class III-IV mutations)
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1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
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3_Islet beta-cell destruction in T1D
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2_Neuron and Schwann cell death
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drug-target molsynthesis
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Differentiation of psoriatic T cells
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