Protein TRAF3

URN urn:agi-llid:7187
Total Entities 0
Connectivity 1126
Name TRAF3
Description TNF receptor associated factor 3
Notes The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
Primary Cell Localization Cytoplasm
ObjectType Protein

Pathway NOD-like Receptors
Antiviral Signaling through Pattern Recognition Receptors
TLR4 Signaling in Leukocytes
T-Cell Independent B-Cell Activation
Immunoglobulin Class-Switch Recombination Activation
Toll-like Receptors in Sterile Inflammation
CD16/CD14 Proinflammatory Monocyte Activation
MAVS in Antiviral Innate Immune Response in Myocarditis
Dendritic Cells Function in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Follicular Lymphoma
Proteins Involved in Hodgkin Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Splenic Marginal Zone Lymphoma
Osteoclast Activation in Multiple Myeloma
Multiple Myeloma
TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
Antigen-Presenting Cell Role in Asthma
B-Cell Mediated IgE Production in Asthma
Osteoclast Activation in Rheumatoid Arthritis
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
NFKB Canonical Signaling Activation in Cancer
NFKB Non-Canonical Signaling Activation in Cancer
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
NFKB Signaling Activation by Blocking of Tumor Suppressors
CD40 -> Expression Targets in Lymph Node
NF-kB non-Canonical Signaling
TNF-alpha/TNFRSF1B Signaling
NF-kB Canonical Signaling
pathway 4
New Pathway (2)
Model of PPARG signaling in psoriasis
sars-cov binding
sars-cov no binding
dsRNA induces innate immunity and INFs in alveolar cells
Dendritic Cell Activation in COVID19
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection

Group Genes with Mutations Associated with Splenic Marginal Zone Lymphoma
Genes with Mutations Associated with Multiple Myeloma
binding partnetrs for SARSs
other partners for SARS

MedScan ID 7187

LocusLink ID 7187
22031
362788

Alias LMP1-associated protein 1
CD40 associated protein I
CRAF1
TRA3_HUMAN
CD40BP
CD40 receptor associated factor I
TRAFAMN
CD40 associated protein 1
TRAF3
IIAE5
TNF receptor-associated factor 3
OTTMUSP00000041798
TRA3
tumor necrosis factor receptor associated factor 3
CD40 binding protein
RING-type E3 ubiquitin transferase TRAF3
CD40 receptor associated factor 1
RNF118
CD40-binding protein
LMP1 associated protein
TNF receptor-associated factor III
CRAF-1
AI528849
CAP I
LAP I
LMP1-associated protein
CAP1
LAP1
CAP-1
amn
T-BAM
CD40 receptor-associated factor 1
tumour necrosis factor receptor associated factor 3

EC Number 2.3.2.27
6.3.2.-

GO ID 0019901
0019903
0031996
0005164
0031625
0004842
0008270
0035666
0008063
0006915
0045087
0032088
0016579
0016567
0042981
0001817
0050688
0032648
0030162
0007165
0002224
0033209
0035631
0009898
0005829
0005768
0005739
0032991
0046872
0016740
0002376
0005737
0006917
0016874
0032480
0034142
0002756
0005515
0034138
0070740
0018169
0070736
0070735
0070738
0070737
0070739
0004871
0043773
0008766
0043774

KEGG ID hsa:7187
mmu:22031
rno:362788

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 12 60.94 cM
12 55.0 cM

OMIM ID 601896
614849

Rat chromosome position 6q32

Hugo ID 12033
HGNC:12033

Human chromosome position 14q32.32

Swiss-Prot Accession Q13114
A6NHG8
Q13114.2
Q3UHJ1
Q60803
Q60803.2
D3Z9G0
B7Z8C4
Q12990
Q13076
Q13947
Q6AZX1
Q9UNL1
B2RPW3
Q62380

PIR ID A55960
S68467
I49272

GenBank ID NC_000014
NM_003300
NP_003291
NM_001199427
NP_001186356
NM_145725
NP_663777
NM_145726
NP_663778
XM_011537117
XP_011535419
XM_011537116
XP_011535418
XM_011537118
XP_011535420
XM_017021620
XP_016877109
XM_017021617
XP_016877106
XM_017021619
XP_016877108
XM_017021618
XP_016877107
NG_027973
AL117209
AL132801
CH471061
EAW81795
EAW81796
EAW81797
AF110908
AAD29276
AK303172
BAH13910
BC075086
AAH75086
BC075087
AAH75087
BQ000015
BX247977
CAD62311
L38509
AAA68195
U15637
AAA56753
U19260
AAA65732
U21092
AAC50112
Q13114
NC_000078
NM_011632
NP_035762
NM_001286122
NP_001273051
XM_006515802
XP_006515865
XM_017315042
XP_017170531
XM_006515798
XP_006515861
XM_006515800
XP_006515863
XM_006515801
XP_006515864
XM_006515799
XP_006515862
NM_001364364
AC122023
AC127580
AF320615
CH466549
EDL18642
AK134159
AK137321
AK147304
BAE27835
AK147362
BAE27866
AK148231
AK217743
AW702148
BC137634
AAI37635
BC137635
AAI37636
BF661650
CJ127244
U21050
AAC52175
Q60803
NC_005105
XM_006240596
XP_006240658
NM_001108724
NP_001102194
AC_000074
AABR07065583
AABR07065584
AABR07065585
AABR07065586
AAHX01046668
AAHX01046669
AAHX01046670
CH474034
EDL97481
XP_006240660
XP_006240662
XP_006240661
XM_006720244
NP_001041671
XP_006240657
AAHY01103548
XP_006240656
XP_006240659
AAHY01103549
AMYH02029907
AMYH02029908
AMYH02029909
XM_006240600
NM_001048206
AMYH02029910
AC_000146
ABBA01048451
ABBA01048450
ABBA01048453
AABR06046334
ABBA01048452
AABR06046332
AABR06046333
AABR06046331
AC_000034
ABBA01048454
NC_018925
XR_943512
XP_006720307
XM_006240599
XM_006240598
XM_006240597
XM_006240595
XM_006240594

Swiss-Prot ID TRAF3_HUMAN
TRAF3_MOUSE

Cell Localization Cytoplasm
Endosome
Mitochondrion

Ensembl ID ENSG00000131323
ENSP00000445998.1
ENST00000539721.5
ENSP00000454207.1
ENST00000560371.5
ENSP00000376500.2
ENST00000392745.6
ENSP00000328003.4
ENST00000347662.8
ENSMUSG00000021277
ENSMUSP00000112517.1
ENSMUST00000117269.7
ENSMUSP00000021706.4
ENSMUST00000021706.10
ENSMUSP00000058361.6
ENSMUST00000060274.6
ENSRNOG00000008145
ENSRNOP00000010906.5
ENSRNOT00000010906.6
ENSRNOP00000074381.1
ENSRNOT00000077770.1
ENSRNOP00000010906
ENSMUSP00000112517
ENSMUST00000021706
ENST00000392745
ENST00000539721
ENSP00000454207
ENSP00000445998
ENSMUSP00000021706
ENSMUSP00000058361
ENSP00000376500
ENSRNOT00000010906
ENSP00000328003
ENSMUST00000117269
ENST00000347662
ENSRNOP00000074381
ENSMUST00000060274
ENSRNOT00000077770
ENST00000560371

MGI ID MGI:108041
108041

RGD ID 1304633

Unigene ID Hs.510528
Mm.27431
Rn.12033

Homologene ID 7981

IPI ID IPI00297473
IPI00973170
IPI00310635