Protein RPTOR

URN urn:agi-llid:57521
Total Entities 0
Connectivity 1344
Name RPTOR
Description regulatory associated protein of MTOR complex 1
Notes This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Primary Cell Localization Cytoplasm
ObjectType Protein

Pathway Oncogene Induced Cellular Senescence
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Hypoxia Inhibits mTOR Signaling
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
MTOR/TP53 Regulates Cell Metabolism
Insulin Influence on Protein Synthesis
SCF/BTRC Complex
Preconditioning Ischemia
Peutz-Jeghers Syndrome
Polycystins Mutation Effects in Cystic Kidney Disease
NOTCH1 -> Expression Targets in Colon
MTOR/TORC in Cancer Cell Motility and Invasion
Respiratory Chain Impairment in Cancer
AMPK Signaling
mTOR Signaling
ace2
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)

MedScan ID 57521

LocusLink ID 57521
74370
287871

Alias RPTOR
KOG1
raptor
regulatory associated protein of MTOR, complex 1
LOC653386
LOC654218
KIAA1303
mKIAA1303
OTTMUSP00000004362
4932417H02
regulatory associated protein of mtor
p150 target of rapamycin (TOR)-scaffold protein
RGD1311784
p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
4932417H02Rik
regulatory associated protein of mammalian target of rapamycin
RP24-225K18.1
Mip1
regulatory-associated protein of mTOR
Rap

GO ID 0071889
0001030
0001031
0001032
0001156
0030674
0030295
0019901
0030291
0044877
0031929
0038202
0032147
0007050
0071230
0071233
0031669
0009267
0071901
1900087
0032008
0030307
0001938
0033138
0010800
0071902
0045945
0001558
0008361
1900034
0016241
0016032
0031931
0005737
0010494
0005829
0030425
0005765
0005764
0043025
0005654
0046676
0042325
0001932
0032403
0016049
0016236
0043231
0034605
0008286

KEGG ID hsa:57521

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 11

OMIM ID 607130

Rat chromosome position 10q32.3

Hugo ID 30287
HGNC:30287

Human chromosome position 17q25.3

Swiss-Prot Accession Q8N122
Q6DKI0
Q8N122.1
A2ACM0
A4FUW1
Q8K4Q0.1
D3ZDU2
B2RN36
C6KEF2
F5H7J5
Q8N4V9
Q8TB32
Q9P2P3
Q8K4Q0

GenBank ID NC_000017
NM_020761
NP_065812
NM_001163034
NP_001156506
NG_013034
AC016245
AC109327
AC127496
AC133012
CH471099
EAW89618
EAW89619
KC877680
AB037724
BAA92541
AB082951
BAC06490
AI821182
AK055912
AK295964
BAG58742
AK296321
BAH12314
AY090663
AAM09075
BC014502
BC025180
AAH25180
BC033258
AAH33258
BC041079
BC064515
AAH64515
BC073898
AAH73898
BC136652
AAI36653
BC136654
AAI36655
BF111734
GQ183898
ACS44766
Q8N122
NC_000077
NM_028898
NP_083174
NM_001306081
NP_001293010
XM_006534363
XP_006534426
XM_006534361
XP_006534424
XM_006534362
XP_006534425
XM_011249286
XP_011247588
XM_011249285
XP_011247587
AL669881
AL928989
AL929234
BX248132
CH466558
EDL34713
EDL34714
EDL34715
AB082952
BAC06491
AK016530
BAB30288
AK029341
AK034306
BAC28669
AK034557
BAC28753
AK034733
AK040288
BAC30561
AK046898
AK081250
AK087217
AK129326
BAC98136
AK137878
AK144082
AK161011
AK172276
BC023733
BC052202
BC059877
BC060140
BC118971
AAI18972
BC148309
AAI48310
Q8K4Q0
NC_005109
NM_001134499
NP_001127971
XM_017597164
XP_017452653
XM_017597165
XP_017452654
AC_000078
AABR07030912
AABR07030913
AABR07030914
AAHX01066964
AAHX01066965
AAHX01066966
AAHX01066967
AAHX01066968
AAHX01066969
AAHX01066970
AAHX01066971
AAHX01066972
CH473948
EDM06799
NC_018928
AMYH02034109
AMYH02034110
AMYH02034111
AMYH02034112
AMYH02034113
AMYH02034114
AMYH02034115
AMYH02034116
AMYH02034117
BC033699
XM_006534364
XP_006534427
AC_000033
AAHY01096916
AAHY01096917
AAHY01096918
AAHY01096919
AAHY01096920
AAHY01096921
AAHY01096922
AAHY01096923
AAHY01096924
AAHY01096925
AAHY01096926
BC167200
AAI67200
AC_000149
ABBA01032115
ABBA01032116
ABBA01032117
ABBA01032118
ABBA01032119
ABBA01032120
ABBA01032121
ABBA01032122

Swiss-Prot ID RPTOR_HUMAN

Cell Localization Cytoplasm
Lysosome
Cytoplasmic granule

Ensembl ID ENSG00000141564
ENSP00000442479.2
ENST00000544334.6
ENSP00000307272.3
ENST00000306801.8
ENSMUSG00000025583
ENSMUSP00000026671.6
ENSMUST00000026671.12
ENSRNOG00000003821
ENSRNOP00000005337.5
ENSRNOT00000005337.6
ENSP00000442479
ENST00000544334
ENSP00000307272
ENST00000306801
ENSMUSP00000026671
ENSMUST00000026671
ENSRNOP00000005337
ENSRNOT00000005337

MGI ID MGI:1921620

RGD ID 1311784

Unigene ID Hs.133044
Mm.209933
Mm.442144
Mm.450470
Mm.462932
Rn.98539

Homologene ID 80210