Protein IFNGR2

URN urn:agi-llid:3460
Total Entities 0
Connectivity 282
Name IFNGR2
Description interferon gamma receptor 2 (interferon gamma transducer 1)
Notes This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway Natural Killer Cell Activation
T-Cell Cytotoxic Mediated Cell Death
Th1-Cell Differentiation
Proplatelet Maturation
Macrophage M1 Lineage
AHR Signaling in M1 Macrophages Function
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Atopic Dermatitis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Th1-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Hashimoto's Thyroiditis
CD4+T-Cell Response in Celiac Disease
Metastatic Colorectal Cancer
Keratinocyte Activation in Psoriatic Arthritis
IFNG -> ARRB1/STAT1 Signaling
Clozapine Induced Granulocytopenia
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
IFNG/IFNR Expression Targets
IFN signaling in alveolar cells
1_Differentiation of psoriatic T cells
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
Differentiation of psoriatic T cells

MedScan ID 3460

LocusLink ID 3460
15980
360697

Alias AF I
IFNGT1
IFNGT I
interferon gamma receptor accessory factor-1
IFN gamma receptor II
IFN gamma receptor 2
Interferon-gamma receptor accessory factor I
interferon gamma receptor 2 (interferon gamma transducer 1)
IFGR2
Interferon-gamma transducer I
IFN-gamma-R-beta
OTTHUMP00000067751
IFN gamma R2
interferon gamma receptor 2
Ifngr2
interferon gamma receptor II
Interferon-gamma transducer-1
interferon gamma receptor beta chain
Ifgt
AF-1 transducer
AF-1
IMD28
IFN-gamma receptor 2
IFN-gamma-R2
interferon gamma transducer 1
interferon gamma receptor accessory factor 1
Ifngr2_predicted

GO ID 0004896
0004906
0007166
0019221
0060333
0060334
0009615
0000139
0030659
0005783
0005789
0005887
0005886
0051607
0001774
1904783
0016021
0004872
0007165

KEGG ID hsa:3460
rno:360697
mmu:15980

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 16 53.07 cM
16 63.3 cM

OMIM ID 147569
614889
209950

Rat chromosome position 11q11

Hugo ID 5440
HGNC:5440

Human chromosome position 21q22.11

Swiss-Prot Accession E7EUY1
A8K881
P38484
P38484.2
Q63953
D4A109
Q9BTL5
Q3UVK9
Q8C352

PIR ID I38500
A49947

GenBank ID NC_000021
NM_001329128
NP_001316057
NM_005534
NP_005525
XM_011529553
XP_011527855
XM_011529554
XP_011527856
NW_003315970
NG_007570
AP000299
AP000300
AP001717
AY644470
AAT45458
CH471079
EAX09834
EAX09835
JA738573
CCF76939
KF457222
KF510547
U68755
AAC52066
AI824138
AK292246
BAF84935
AK314005
BAG36717
BC003624
AAH03624
BG391103
BQ008968
CB992729
EF173886
ABM53159
U05875
AAA16955
U05877
AAA16956
P38484
NC_000082
NM_008338
NP_032364
AC159199
AH006761
AAC52938
CH466602
EDL03824
AK086929
BAC39764
AK087158
AK137165
BAE23260
AK143214
BAE25310
AK146995
AK165193
BAE38071
AK169907
BC055745
AAH55745
S69336
AAB30165
NC_005110
NM_001108313
NP_001101783
AC_000079
AAHX01068281
AC120974
CH473989
EDM10726
FQ227918
AAHY01130195
AAHY01130194
U69599
U69598
U69597
U69596
U69595
U69594
AMYH02037737
AMYH02037736
ABM86448
XP_005261026
AC_000038
XM_005260969
DQ895522
AABR06067655
AC_000153
NC_018932
ABM83246
ABBA01057341
ABBA01057340
ABBA01057342
DQ892320
NT_011512
NW_927384
NW_001838706
AC_000064
CR592484
CR592823
CR596056
CR598065
CR600779
CR602883
CR607346
CR607841
CR614391
CR617048
CR617094
CR617691
CR618682
CR621659
CR624031
NT_039625
NW_001030587
Q3UVK9
Q63953
Q8C352
NW_001084660
NW_047354

Swiss-Prot ID INGR2_HUMAN
A8K881_HUMAN
Q63953_MOUSE
D4A109_RAT

Cell Localization Cell membrane
Cytoplasmic vesicle membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane
Cytoplasm
Membrane
Plasma membrane

Ensembl ID ENSG00000159128
ENSP00000371425.1
ENST00000381995.5
ENSP00000290219.5
ENST00000290219.10
ENSMUSG00000022965
ENSMUSP00000023687.7
ENSMUST00000023687.8
ENSRNOG00000002032
ENSRNOP00000002779.5
ENSRNOT00000002779.5
ENSRNOP00000002779
ENSMUST00000023687.7
ENST00000381995
ENSMUSP00000023687
ENSMUST00000023687
ENSP00000371425
ENST00000290219
ENSP00000290219
ENSRNOT00000002779

MGI ID MGI:107654
107654

RGD ID 1307532

Unigene ID Hs.634632
Rn.23305
Mm.249364

Homologene ID 4041

Shape Stick-vertex

IPI ID IPI00221193
IPI00135751
IPI00373039
IPI00658181
IPI00878832
IPI00893563
IPI00894187
IPI00893797