URN | urn:agi-llid:5468 |
---|---|
Total Entities | 0 |
Connectivity | 13252 |
Name | PPARG |
Description | peroxisome proliferator activated receptor gamma |
Notes | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Nucleus |
Class | Transcription factor |
ObjectType | Protein |
Pathway | Proteins Involved in Stem Cell Exhaustion in Aging |
---|---|
Oxidative Stress in Amyotrophic Lateral Sclerosis | |
Estrogen Deficiency in Female Obesity | |
Androgen Deficiency in Male Obesity | |
mTOR Signaling | |
A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis | |
Thyroid Hormones Common Genomic Effects in Hyperthyroidism | |
Androgens in Adipocyte Activation | |
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation | |
Mast-Cell Activation via IgE Signaling | |
Neutrophil Recruitment and Priming | |
Gastric and Pancreatic Lipase Function | |
Adipokines Production by Adipocyte | |
Peroxisome Protein Import and Peroxisome Division | |
Proteins Involved in Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy | |
Proteins Involved in Atherosclerosis | |
Low-Density Lipoproteins and Chemokines in Atherosclerosis | |
Proteins Involved in Dilated Cardiomyopathy | |
Proteins Involved in Arterial Hypertension | |
Proteins Involved in Pulmonary Hypertension | |
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension | |
Proteins Involved in Myocarditis | |
Sebocyte Proliferation in Acne Vulgaris | |
Hyperseborrhea in Acne Vulgaris | |
Androgens in Sebocyte Maturation | |
Proteins Involved in Melanoma | |
Proteins Involved in Diabetes Mellitus Type 1 | |
Proteins Involved in Diabetes Mellitus Type 2 | |
Familial Partial Lipodystrophy Type 4 Progression (Hypothesis) | |
Familial Partial Lipodystrophy Type 3 Progression (Hypothesis) | |
Familial Partial Lipodystrophy Type 2 Progression (Hypothesis) | |
Berardinelli-Seip Syndrome Progression (Hypothesis) | |
Proteins Involved in Diabetic Nephropathy | |
Proteins Involved in Diabetic Neuropathy | |
Proteins Involved in Insulin Resistance | |
Adiponectin Synthesis Declines in Insulin Resistance | |
Proteins Involved in non-Alcoholic Fatty Liver Disease | |
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease | |
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease | |
beta-Cell Recovery in Diabetes Mellitus | |
Thyroid Hormones in Adipose Tissue Metabolism | |
Adipocyte Hypertrophy and Hyperplasia | |
Adipokines Production by Adipocyte Impaired in Obesity | |
Proteins Involved in Obesity | |
Proteins Involved in Colorectal Neoplasms | |
Metastatic Colorectal Cancer | |
Proteins Involved in Inflammatory Bowel Diseases | |
Proteins Involved in Helicobacter Infections | |
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis | |
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis | |
Proteins Involved in Ulcerative Colitis | |
Mast-Cell Activation in Asthma | |
Proteins Involved in Osteoarthritis | |
Proteins Involved in Polycystic Ovary Syndrome | |
Proteins Involved in Psoriatic Arthritis | |
Proteins Involved in Rheumatoid Arthritis | |
Proteins Involved in Periodontitis | |
PPARGC1A Repression in Huntington Disease | |
Proteins Involved in Huntington Disease | |
Proteins Involved in Lipodystrophy, Familial Partial | |
Lipodystrophy, Familial Partial | |
Proteins Involved in Osteopetrosis | |
Proteins Involved in Alzheimer's Disease | |
Proteins Involved in Glioma | |
Proteins Involved in Neuroblastoma | |
Proteins with Altered Expression in Amyotrophic Lateral Sclerosis | |
Proteins Involved in Endometriosis | |
Proteins Involved in Cholesteatoma | |
Fatty Acid Synthase (FASN) Signaling | |
Proteins Involved in Prostate Cancer | |
Proteins Involved in Chronic Obstructive Pulmonary Disease | |
Elevated Receptors -> Expression Targets in Adipose Tissue | |
CSF2 -> STAT Expression Targets | |
EGF -> CTNN Expression Targets | |
EGF -> AP-1/ATF Expression Targets | |
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets | |
EGF -> STAT Expression Targets | |
VEGFA Dependent Angiogenesis in Cancer | |
Cancer Cells Inhibit Adipocyte Differentiation | |
Insulin -> STAT Expression Targets | |
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
Insulin -> MEF/MYOD Expression Targets | |
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets | |
IL13 Expression Targets | |
IL11 Expression Targets | |
IL4 Expression Targets | |
Leptin -> STAT Expression Targets | |
LDLR -> Expression Targets in Lymphoid System and Blood | |
OR1A1 -> GNAS Signaling | |
OSM/OSMR Expression Targets | |
PRL/GHR -> STAT Expression Targets | |
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets | |
Lysophosphatidic Acid/LPARs Signaling | |
FOXO1 Signaling | |
TGFB1-ACVRL1 Expression Targets | |
TNF -> STAT Expression Targets | |
New Pathway (1) | |
PPAR Psoriasis | |
prarg negative regulators, ps-positive | |
pprarg neg, uknown targets, ps-positive | |
prarg neg,ukn expres targets, ps-positive | |
PPARG inhibits phenotypes assotiated with psoriasis | |
PPARG expressed in cells assotiated with psoriasis | |
efects selected | |
comon ps_pos, pprarg_neg targets | |
Model of PPARG signaling in psoriasis | |
PPARG negative regulators and targets | |
Model of PPARG related pathways in psoriasis (short version) | |
New Pathway (5) | |
PPARG-CCK4_MME | |
PPARs and anxiety common targets | |
Amygdaloid expressed genes | |
Figure 3_Mixed network of dexamethasone targets | |
Figure 3_Mixed network of dexamethasone targets | |
3_Increased proliferation of sebocytes in acne vulgaris | |
2_Hyperseborrhea in acne vulgaris | |
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension | |
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature | |
1_Intestine epithelial cell dysfunction in ulcerative colitis | |
4_1_Polymorphisms associated with inflammatory bowel diseases | |
1_Triglyceride storage in NAFLD | |
3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation | |
4_3_Insulin resistance: FFA-related insulin resistance | |
2_2_Effects of thyroid hormone deficiency: cell-specific effects of thyroid hormone action | |
drug-target pairs direct regulation | |
Model of PPARG signaling in psoriais (tested) | |
before laser treatment | |
mapk1 | |
Anti-psoriatic drugs influence PPARG signaling | |
PPARG signaling after laser treatment |
Group | Genes with Mutations Associated with Atherosclerosis |
---|---|
Proteins Involved in Graves Ophthalmopathy | |
Genes with Mutations Associated with Obesity | |
Genes Associated with Ulcerative Colitis | |
Genes with Mutations Associated with Familial Partial Lipodystrophy |
MedScan ID | 5468 |
---|
LocusLink ID | 5468 |
---|---|
19016 | |
25664 |
Alias | peroxisomal proliferator activated receptor gamma 2 |
---|---|
OTTHUMP00000185030 | |
PPARc | |
PPAR-gamma | |
Peroxisome proliferator activated receptor gamma | |
PPARG | |
HUMPPARG | |
PPARG I | |
PPAR-C | |
peroxisome proliferative activated receptor gamma isoform I | |
peroxisomal proliferator (PP)-activator receptor gamma | |
peroxisomal proliferator activated receptor-c | |
peroxisome proliferators-activated receptor gamma | |
peroxisomal proliferator-activator receptor gamma | |
nuclear receptor subfamily 1 group C member 3 | |
OTTHUMP00000185032 | |
peroxisome proliferator-activated receptor gamma 1 | |
peroxisome proliferator activated receptor gamma 2 | |
PPAR-gamma2 | |
peroxisome proliferator (PP)-activator receptor gamma | |
OTTHUMP00000185036 | |
peroxisome proliferative activated receptor gamma isoform II | |
PPARG2 | |
NR1C3 | |
peroxisome proliferator (PP)-activated receptor gamma | |
peroxisome proliferative activated receptor gamma isoform 1 | |
OTTHUMP00000185033 | |
CIMT1 | |
PPARG1 | |
peroxisome proliferator-activator receptor gamma | |
peroxisome proliferative activated receptor gamma | |
peroxisomal proliferator (PP)-activated receptor gamma | |
peroxisome proliferators-activated receptor gamma 1 | |
peroxisome proliferative activated receptor gamma isoform 2 | |
OTTHUMP00000185037 | |
peroxisome proliferator-activated nuclear receptor gamma variant 1 | |
peroxisomal proliferator-activated receptor gamma 1 | |
peroxisomal proliferator activated receptor gamma | |
peroxisome proliferator activated receptor gamma 4 | |
PPAR-G | |
GLM1 | |
PPARgamma | |
peroxisome proliferator-activated receptor gamma | |
PPARgamma2 | |
peroxisome proliferator activator receptor, gamma | |
PPAR gamma |
GO ID | 0050692 |
---|---|
0003677 | |
0003700 | |
0000981 | |
0001227 | |
0070888 | |
0050693 | |
0000977 | |
0001103 | |
0033613 | |
0051393 | |
0050544 | |
0003682 | |
0003690 | |
0008144 | |
0019899 | |
0030331 | |
0005504 | |
0008289 | |
0004879 | |
0030374 | |
0042277 | |
0004955 | |
0008022 | |
0046982 | |
0019903 | |
0043621 | |
0046965 | |
0043565 | |
0038023 | |
0003707 | |
0008134 | |
0044212 | |
0000976 | |
0008270 | |
0007186 | |
0006919 | |
0031100 | |
0030154 | |
0045165 | |
0048469 | |
0071455 | |
0032869 | |
0071404 | |
0071380 | |
0071300 | |
0071306 | |
0030855 | |
0006631 | |
0019395 | |
0042593 | |
0007507 | |
0009755 | |
0045087 | |
0055088 | |
0006629 | |
0042953 | |
0015909 | |
0045713 | |
0010742 | |
0030224 | |
0007275 | |
0002674 | |
0016525 | |
0043537 | |
0030308 | |
0010887 | |
0032966 | |
0060965 | |
0060336 | |
0010745 | |
2000230 | |
0010871 | |
0010891 | |
0048662 | |
0051974 | |
0000122 | |
0045892 | |
1905563 | |
1904706 | |
0035357 | |
0001890 | |
0043388 | |
0051091 | |
0045600 | |
0046321 | |
0048714 | |
0060100 | |
0045944 | |
0045893 | |
1905461 | |
0061614 | |
0008217 | |
0060694 | |
0042752 | |
0019216 | |
0006357 | |
0060850 | |
0031000 | |
0009409 | |
0043627 | |
0035902 | |
0033993 | |
0009612 | |
1901558 | |
0007584 | |
0032526 | |
0042594 | |
0033189 | |
0048511 | |
0007165 | |
0043401 | |
0006367 | |
0050872 | |
0090575 | |
0005829 | |
0043231 | |
0005654 | |
0005634 | |
0048471 | |
0032991 | |
0001228 | |
0001012 | |
0050699 | |
0046872 | |
0050873 | |
0071285 | |
0071407 | |
0002024 | |
0045444 | |
0006954 | |
0008285 | |
1900077 | |
0001818 | |
1903979 | |
0150079 | |
0090278 | |
0043065 | |
0045598 | |
0010468 | |
0006355 | |
0002021 | |
0032094 | |
0009416 | |
0005737 | |
0071379 | |
0010629 | |
0010875 | |
0032385 | |
0031394 | |
0050714 | |
1903076 | |
0042493 | |
0014070 | |
0010033 | |
0045923 | |
0071396 | |
0050728 | |
0098531 | |
0006351 | |
0031667 | |
0001076 | |
0001078 | |
0001046 | |
0030522 | |
0010467 | |
0036270 | |
0055098 | |
0005794 | |
0006366 | |
0006917 | |
0032717 | |
0010843 | |
0016566 | |
0016563 | |
0016564 | |
0010553 | |
0010552 | |
0034339 | |
0004872 | |
0017053 |
KEGG ID | hsa:5468 |
---|---|
mmu:19016 | |
rno:25664 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 6 53.41 cM |
---|---|
6 52.7 cM |
OMIM ID | 601487 |
---|---|
609338 | |
125853 | |
604367 | |
601665 | |
137800 | |
151660 |
Rat chromosome position | 4q42 |
---|
Hugo ID | 9236 |
---|---|
HGNC:9236 |
Human chromosome position | 3p25.2 |
---|---|
3p25 |
Swiss-Prot Accession | E9PFX5 |
---|---|
Q4W448 | |
D2KUA6 | |
P37231 | |
P37231.3 | |
M1VPI1 | |
P37238 | |
Q6GU14 | |
P37238.3 | |
O88275 | |
O88275.2 | |
A8K3G6 | |
B5BUA1 | |
O00684 | |
O00710 | |
O14515 | |
Q0QJH8 | |
Q15178 | |
Q15179 | |
Q15180 | |
Q15832 | |
Q86U60 | |
Q96J12 | |
Q9QWG0 | |
Q9R197 | |
Q4FJR2 | |
Q4W4C6 | |
Q4W4C7 | |
Q53EW1 | |
Q6L9M1 | |
Q86WD1 | |
Q9UEF6 | |
Q6TQE4 |
PIR ID | JC4859 |
---|---|
PC4290 | |
PC4429 | |
A54101 |
Swiss-Prot ID | PPARG_HUMAN |
---|---|
PPARG_MOUSE | |
PPARG_RAT | |
Q6GU14_MOUSE | |
Q4FJR2_MOUSE | |
D2KUA6_HUMAN |
Cell Localization | Nucleus |
---|---|
Cytoplasm |
Ensembl ID | ENSG00000132170 |
---|---|
ENSP00000380196.2 | |
ENST00000397000.6 | |
ENSP00000380205.3 | |
ENST00000397010.7 | |
ENSP00000499004.1 | |
ENST00000651826.1 | |
ENSP00000287820.6 | |
ENST00000287820.10 | |
ENSP00000380207.2 | |
ENST00000397012.7 | |
ENSP00000498354.1 | |
ENST00000650761.1 | |
ENSMUSG00000000440 | |
ENSMUSP00000131962.1 | |
ENSMUST00000171644.7 | |
ENSMUSP00000145525.1 | |
ENSMUST00000203732.2 | |
ENSMUSP00000000450.3 | |
ENSMUST00000000450.4 | |
ENSRNOG00000008839 | |
ENSRNOP00000045012.3 | |
ENSRNOT00000051858.5 | |
ENSRNOP00000073235.1 | |
ENSRNOT00000082969.1 | |
ENSRNOP00000012137.3 | |
ENSRNOT00000012137.5 | |
ENSP00000380196.1 | |
ENSP00000312472.6 | |
ENST00000397000.5 | |
ENSP00000380205.2 | |
ENST00000397015.6 | |
ENST00000309576.10 | |
ENST00000643197.1 | |
ENSP00000380210.2 | |
ENSP00000495840.1 | |
ENST00000397010.6 | |
ENST00000397012.6 | |
ENSRNOP00000045012 | |
ENST00000287820 | |
ENSMUSP00000000450 | |
ENSP00000380196 | |
ENST00000397000 | |
ENSP00000312472 | |
ENSRNOT00000051858 | |
ENSMUST00000203732 | |
ENSRNOT00000012137 | |
ENSRNOT00000082969 | |
ENSP00000380205 | |
ENSMUST00000000450 | |
ENST00000397015 | |
ENSP00000287820 | |
ENST00000397012 | |
ENST00000397010 | |
ENSP00000380207 | |
ENST00000309576 | |
ENSRNOP00000073235 | |
ENSMUSP00000131962 | |
ENSMUST00000171644 | |
ENSRNOP00000012137 | |
ENSMUSP00000145525 | |
ENSP00000380210 |
MGI ID | MGI:97747 |
---|---|
97747 |
RGD ID | 3371 |
---|
Unigene ID | Rn.23443 |
---|---|
Mm.3020 | |
Hs.162646 | |
Hs.655798 |
Homologene ID | 7899 |
---|
Shape | Stick-vertex |
---|
IPI ID | IPI00020897 |
---|---|
IPI00853091 | |
IPI00926009 | |
IPI00207539 | |
IPI00231890 | |
IPI00125193 | |
IPI00266075 | |
IPI00913931 | |
IPI00797909 | |
IPI00852773 | |
IPI00791321 | |
IPI00853034 | |
IPI00853274 | |
IPI00896034 |