Protein IL17RC

URN urn:agi-llid:84818
Total Entities 0
Connectivity 250
Name IL17RC
Description interleukin 17 receptor C
Notes This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway IL17 Signaling in Psoriasis
Il17 Signaling Related Neutrophilia in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Endometriosis
Cytokines Trigger Otitis Media
2_Interleukin-17 and interleukin-22 signaling in psoriasis
3_2_Regulation of airway surface liquid (ASL) thickness
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 84818

LocusLink ID 84818
171095
297520

Alias Gm19850
FLJ95963
IL17F receptor
interleukin 17 receptor-like
1110025H02Rik
interleukin 17 receptor C
OTTMUSP00000028724
zcytoR14
OTTHUMP00000180659
RIKEN cDNA 1110025H02 gene
interleukin IL17 receptor-like
interleukin IL17F receptor
LOC100503711
UNQ6118/PRO20040/PRO38901
interleukin 17F receptor
OTTMUSP00000028725
MGC10763
interleukin IL17 receptor C
OTTHUMP00000207644
IL17RC
OTTMUSP00000028723
CANDF9
IL17rl
IL-17 receptor C
FLJ96005
interleukin IL17RC
interleukin IL17rl
1110025H02
OTTHUMP00000207646
IL17-RL
IL-17RL
IL17Rhom
interleukin-17 receptor homolog
interleukin-17 receptor-like protein
interleukin-17 receptor C
IL-17RC
IL17-RC

GO ID 0030368
0005102
0050832
0071621
0097400
1900017
2000778
0009986
0016021
0005886
0016020
0019221
0005887

KEGG ID hsa:84818
mmu:171095

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6

OMIM ID 610925
616445

Rat chromosome position 4q42

Hugo ID 18358

Human chromosome position 3p25.3

Swiss-Prot Accession Q8NAC3
Q8NAC3.2
Q8BPI5
Q8K4C2
Q8K4C2.3
D3ZIM0
A8BWC1
A8BWC9
A8BWD5
E9PHG1
E9PHJ6
Q6UVY3
Q6UWD4
Q8NFS1
Q9BR97
G3X9C0
Q99J43

GenBank ID NC_000003
NR_037807
NM_001203264
NP_001190193
XM_017007327
XP_016862816
XM_017007329
XP_016862818
XM_017007336
XP_016862825
XM_024453793
XP_024309561
XM_017007339
XP_016862828
XM_017007338
XP_016862827
XM_017007326
XP_016862815
NM_153461
NP_703191
XM_017007333
XP_016862822
XM_017007328
XP_016862817
XM_017007330
XP_016862819
XM_017007331
XP_016862820
XM_017007332
XP_016862821
XM_017007335
XP_016862824
XM_024453794
XP_024309562
XM_017007334
XP_016862823
XM_017007337
XP_016862826
XM_017007340
XP_016862829
NM_153460
NP_703190
NM_001203263
NP_001190192
NM_001367278
NP_001354207
XM_017007341
XP_016862830
NM_032732
NP_116121
NM_001367280
NP_001354209
NM_001203265
NP_001190194
XM_017007345
XP_016862834
XM_017007348
XP_016862837
XM_017007342
XP_016862831
XM_017007343
XP_016862832
XM_017007347
XP_016862836
NM_001367279
NP_001354208
NG_029376
AC018809
CH471055
EAW64021
EAW64022
EAW64023
EAW64024
EAW64025
EAW64026
EAW64027
EAW64028
EAW64029
EAW64030
EAW64031
EAW64032
CS399136
CAL44891
CS399138
CAL44892
GM832015
CAV28583
GM832017
CAV28584
GM832034
CAV28588
JA381717
CCB07365
JA381719
CCB07366
KF457576
AF458065
AAM77569
AK075534
BAC11677
AK092907
BAC04001
AK094746
AK096824
AK225650
AK290670
BAF83359
AK294616
BAG57799
AK295377
BAG58336
AK303171
BAG64270
AK308241
AK315024
AK315053
AY358840
AAQ89199
AY359098
AAQ89456
BC006411
DC381087
DC386743
EF676032
ABV44615
EF676033
ABV44616
EF676034
ABV44617
Q8NAC3
NC_000072
NM_178942
NP_849273
NM_134159
NP_598920
XM_006505665
XP_006505728
XM_006505666
XP_006505729
XR_001785101
XM_006505668
XP_006505731
XM_006505667
XP_006505730
AC153910
CH466523
EDK99476
EDK99477
EDK99478
CS135270
CAJ21523
AF458066
AAM77570
AI463827
AI592368
AK033890
AK040950
AK075634
BAC35870
AK209010
AW045329
BC004759
AAH04759
BQ551040
BY018830
Q8K4C2
NC_005103
XM_017592574
XP_017448063
XM_017592575
XP_017448064
XM_017592576
XP_017448065
XM_017592577
XP_017448066
XM_017592578
XP_017448067
XM_017592579
XP_017448068
NM_001170565
NP_001164036
XM_017592581
XP_017448070
XM_017592580
XP_017448069
AC_000072
AAHX01032391
AC117950
CH473957
EDL91541
BQ192107
CB764502
CB793227
CB802860
CN541827
DV727885
NC_018914
AMYH02006240
XM_006505669
XP_006505732
AC_000028
AAHY01056660

Swiss-Prot ID I17RC_HUMAN
I17RC_MOUSE

Cell Localization Cell membrane

Ensembl ID ENSG00000163702
ENSP00000396064.1
ENST00000413608.2
ENSP00000395315.3
ENST00000416074.6
ENSP00000407894.1
ENST00000455057.5
ENSP00000373323.4
ENST00000383812.9
ENSP00000384969.3
ENST00000403601.8
ENSP00000295981.3
ENST00000295981.7
ENST00000466046.5
ENSMUSG00000030281
ENSMUSP00000055343.7
ENSMUST00000058300.13
ENSMUSP00000145038.1
ENSMUST00000205208.2
ENSRNOG00000027376
ENSRNOP00000037747.5
ENSRNOT00000037788.6
ENSP00000396064
ENST00000413608
ENSP00000395315
ENST00000416074
ENSP00000407894
ENST00000455057
ENSP00000373323
ENST00000383812
ENSP00000384969
ENST00000403601
ENSP00000295981
ENST00000295981
ENST00000466046
ENSMUSP00000055343
ENSMUST00000058300
ENSMUSP00000145038
ENSMUST00000205208
ENSRNOP00000037747
ENSRNOT00000037788

MGI ID MGI:2159336

RGD ID 1306392

Unigene ID Hs.129959
Mm.213397
Rn.139872

Homologene ID 15894