Protein RORC

URN urn:agi-llid:6097
Total Entities 0
Connectivity 7054
Name RORC
Description RAR related orphan receptor C
Notes The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway T-Cell Positive Selection and Neglect Induced Death
Kynurenine/AHR Signaling in Treg Cell Activation
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Th17-Cell Activation in Crohn's Disease
Th17-Cell Differentiation in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
IL27R -> STAT Signaling
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
Chemokine Receptor Family -> Expression Targets in Lymphoid System
PPAR Psoriasis
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of cancer progression
Neighbors of disease severity
Neighbors of mortality
Neighbors of insulin sensitivity
Neighbors of tumor response
Neighbors of body weight gain
Neighbors of glucose tolerance
Neighbors of blood glucose
Neighbors of T-cell count
Neighbors of disease exacerbation
Neighbors of cancer progression
Neighbors of disease severity
Neighbors of mortality
Neighbors of insulin sensitivity
Neighbors of tumor response
Neighbors of body weight gain
Neighbors of glucose tolerance
Neighbors of blood glucose
Neighbors of T-cell count
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of cell function
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of T-cell proliferation
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of cell count
Neighbors of adipogenesis
Neighbors of cell damage
Neighbors of aging
Neighbors of adipocyte differentiation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of transcription activation
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of cell transdifferentiation
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of cellular immune response
Neighbors of cell differentiation
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of metastasis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of obesity
Neighbors of asthma
Neighbors of pneumonia
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of insulin resistance
Neighbors of infection
Neighbors of preeclampsia
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of autoimmunity
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of breast cancer
Neighbors of systemic lupus erythematosus
Neighbors of stroke
Neighbors of neoplasm
Neighbors of respiratory hypersensitivity
Neighbors of pancreatic cancer
Neighbors of macrophage
Neighbors of PBMC
Neighbors of neutrophil
Neighbors of immunocompetent cell
Neighbors of NF-kB family
Neighbors of IL1 family
Neighbors of PI3K
Neighbors of STAT family
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of NF-AT family
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of LXR
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of IL12
Neighbors of Notch
Neighbors of interleukin-35
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of retinoid-X receptor subfamily
Neighbors of immunoglobulin
Neighbors of AHR subfamily
Neighbors of RA receptor
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway (5)
1_Differentiation of psoriatic T cells
Model of PPARG signaling in psoriais (tested)
before laser treatment
Differentiation of psoriatic T cells
Anti-psoriatic drugs influence PPARG signaling
PPARG signaling after laser treatment

MedScan ID 6097

LocusLink ID 6097
19885
102556141

Alias RORC
IMD42 locus
OTTMUSP00000025974
RZRG
MGC129539
thymus orphan receptor
OTTMUSP00000025973
RORG
thymus orphan receptors
RAR-related orphan receptor gamma
nuclear receptor subfamily 1 group F member 3
RAR-related orphan receptor C
nuclear receptor ROR-gamma
OTTHUMP00000015253
nuclear receptor ROR-gamma-like
retinoid-related orphan receptor gamma
RP11-98D18.11-001
NR1F3
retinoic acid-binding receptor gamma
RAR-related orphan nuclear receptor variant 2
RAR-related orphan receptor C, isoform a
RORgamma
RZR-gamma
nuclear receptor NR1F3
RORgammat
Nuclear receptor RZR-gamma
LOC102556141
RP11-98D18.11
MGC189525
transcription factor NR1F3
TOR
IMD42
Thor
retinoid-related orphan receptor-gamma

GO ID 0003700
0000981
0001227
0000978
0004879
0008142
0003707
0001223
0098531
0008270
0072539
0060612
0036315
0032922
0019221
0030522
0000122
0042753
0045893
0045598
0010906
0019218
0060850
0043401
0006367
0006805
0016604
0005654
0005634
0003677
0046872
0043565
0048541
0033077
0042093
0046632
0030154
0032620
0072615
0048535
0048537
0007275
0070244
0006468
0045586
0006355
0048511
0009897
0006351
0001078
0043231
0005730
0010467

KEGG ID hsa:6097
mmu:19885

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 3

OMIM ID 602943
616622

Rat chromosome position 2

Hugo ID 10260
HGNC:10260

Human chromosome position 1q21.3
1q21

Swiss-Prot Accession F1D8P6
P51449
Q6I9R9
P51449.2
A0A0G2JGZ6
P51450
A0A0R4J096
P51450.1
Q5SZR9
Q8N5V7
Q8NCY8
E9Q8I1
Q3U513
Q61027
Q91YT5
Q9QXD9
Q9R177

PIR ID JC2494
JC5375

GenBank ID NC_000001
XM_006711484
XP_006711547
NM_005060
NP_005051
NM_001001523
NP_001001523
NG_029118
AL589765
CH471121
EAW53405
EAW53406
KT583857
AB307696
BAH02287
AF075096
AK097994
BAG53561
AK128522
AK223137
BAD96857
AK298460
BAG60673
AK315662
BAG38028
AL834219
CAD38900
AW004872
BC031554
AAH31554
BC110571
AAI10572
BI520481
CB161467
CR457436
CAG33717
DB148892
HQ692834
ADZ17345
KY670636
AUT36352
U16997
AAA64751
P51449
NC_000069
XM_006501164
XP_006501227
XM_006501163
XP_006501226
NM_011281
NP_035411
NR_121656
NM_001293734
NP_001280663
XM_006501162
XP_006501225
AC164562
AH006790
AAC53501
AJ131723
CAA10488
CH466620
EDL38724
EDL38725
AF163668
AAD46913
AJ132394
CAA10661
AK137866
BAE23510
AK153941
BAE32267
AK160122
BAE35645
BC014804
AAH14804
BF019665
CJ098183
U39071
AAB02582
U43508
AAB40709
P51450
XR_426792
NC_018912
AMYH02001889
AM393818
CAL38693
AM393876
CAL38751
DQ890805
ABM81731
DQ893960
ABM84886
AC_000025
AAHY01029210
AAHY01029211
AAHY01029212
AAHY01029213
AF019655
AF019656
AF019657
AF019658
AF019659
AF019660
XM_005245424
XP_005245481
AC_000133
ABBA01049405
XM_006501161
XP_006501224
XR_375502

Swiss-Prot ID RORG_HUMAN
RORG_MOUSE

Cell Localization Nucleus

Ensembl ID ENSG00000143365
ENSP00000349164.6
ENST00000356728.10
ENSP00000327025.6
ENST00000318247.7
ENSMUSG00000028150
ENSMUSP00000143763.1
ENSMUST00000197040.4
ENSMUSP00000029795.3
ENSMUST00000029795.9
ENST00000318247.6
ENSP00000349164
ENST00000356728
ENSP00000327025
ENST00000318247
ENSMUSP00000143763
ENSMUST00000197040
ENSMUSP00000029795
ENSMUST00000029795

MGI ID MGI:104856

RGD ID 7523591

Unigene ID Hs.607993
Mm.4372
Hs.256022

Homologene ID 21051

Shape Stick-vertex