Protein MAPK9

URN urn:agi-llid:5601
Total Entities 0
Connectivity 2770
Name MAPK9
Description mitogen-activated protein kinase 9
Notes The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Osteoarthritis
Skin Aging
MTHFR Activity Regulation
Dopamine Receptors Signaling
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Nociception Expression Targets Signaling
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Myocardial Remodeling
Myocardial Infarction
Inflammatory Reaction in Acne Vulgaris
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
IL17 Signaling in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Treg-Cell Activation in Diabetes Mellitus
Proteins Involved in Diabetes Mellitus Type 2
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
CD4+T-Cell Response in Celiac Disease
OipA Signaling in Helicobacter Pylori Infection
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Osteoclast Activation in Multiple Myeloma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
Th2-Cell Response in Asthma
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
CCR5 Signaling in Macrophages
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Glioma Invasion Signaling
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
WNT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
Steroids Induced Cataract
WNT Signaling in Cystic Kidney Disease
Podocyte Dysfunction in Glomerulonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> AP-1 Expression Targets
Dopamine/Gi Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB2 -> TP53 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FrizzledR -> JUN/PAX2 Signaling
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Apoptosis Block by BCL2 Family Proteins in Cancer
VEGFA Dependent Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
S1P Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
GNRH2 Expression Targets
EDN1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
AngiopoietinR -> AP-1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TGFBR -> AP-1 Signaling
TNF-alpha/TNFRSF1A Signaling
JNK/MAPK Signaling
VEGF Signaling
EGFR Signaling
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
T-Cell Receptor -> AP-1 Signaling
TGFA -> TP53 Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
TLR9 Expression Targets
TLR -> AP-1 Signaling
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
WNT1 Expression Targets
WNT3A Expression Targets
WNT4 Expression Targets
WNT5A Expression Targets
WNT7A Expression Targets
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Formation of cysts in polycystic kidney disease
2_Podocyte dysfunction in glomerulonephritis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
2_Neuron and Schwann cell death
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Ageing (non-Mammalian Animal Model)

Source curated
GO component

MedScan ID 5601

LocusLink ID 5601
26420
50658
50657
19100
103866
534125
562552

Alias mitogen activated protein kinase 9
stress-activated protein kinase 1a
MK09_HUMAN
protein kinase mitogen-activated 9
c-Jun N-terminal kinase 2
SAPK-alpha
MK09
mitogen-activated protein kinase 9 isoform JNK2 alpha2
OTTMUSP00000005726
p54-alpha
JNK/SAPK alpha
stress activated protein kinase alpha II
Stress-activated protein kinase JNK2
OTTMUSP00000005727
c-Jun kinase 2
SAPK1a
OTTMUSP00000005725
RP23-10G21.6
JNK-55
PRKM9
OTTMUSP00000005728
OTTHUMP00000161543
c-Jun N-terminal kinase II
p54JNK2
MAP kinase 9
JNK2BETA
c-Jun kinase II
OTTHUMP00000161542
Jun kinase 2
JNK2ALPHA
JNK/SAPK
AI851083
p54aSAPK
Jun kinase II
JNK2
kinase JNK2
MAPK9
JNK2A
JNK2B
SAPK
p54a
Jun kinase
MAPK 9
mitogen-activated protein kinase 9
protein kinase, mitogen-activated 9
Stress-activated protein kinase JNK2
protein kinase mitogen-activated 9 (MAP kinase)
IL23R
interleukin-23 receptor
MAPK9.
protein kinase JNK2

EC Number 2.7.11.24
2.7.1.-
2.7.1.37

GO ID 0005524
0004705
0004707
0004712
0008134
0038095
0007254
0007258
0071276
0071310
0034614
0035556
0048666
0018105
0043065
2001235
0010628
0010744
0071803
0031398
1901485
0061833
0006468
0051090
0042752
0010468
0009612
0048511
0005737
0005829
0005739
0043005
0005654
0005634
0008656
0016301
0031435
0000166
0004672
0004674
0016740
0034644
0031175
0016310
0010770
0032722
0043280
0045429
0051770
0031394
0032308
0001934
0045893
0046328
0031396
0001836
0046686
0042493
0043204
0000165
0006919
0071474
1904646
0071363
0071347
0071222
0071356
0007417
0006626
0014075
1990089
0010033
0009636
0009414
0006950
0005622
0002755
0002756
0035666
0045087
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0016772
0008063
0034130
0023014
0044445
0031558
0008152
0051773
0051789
0007165
0005515
0045941
0034097
0032496
0004713
0016020
0004682
0004691

KEGG ID hsa:5601
mmu:26420
rno:50658

MedLine Reference 10381549
10471813
10490605
10523642
10629060
10669748
10797012
10811224
11024282
11042694
11057897
11062067
11172026
11278395
11278789
11359773
11527157
11566021
11602244
11948398
11959861
12023963
12110590
12167088
12171600
12189133
12225289
12417588
12477932
12538493
12743126
12788955
12818176
14504284
14724588
15158451
15262983
15326485
15474087
15489334
15527495
15637069
15655348
15693750
15778501
15860507
15911620
1602151
16169070
16189514
16381010
16412424
16552729
17074809
17192257
17296730
17397142
602896
7737129
7969172
8001819
8548291
8626452
8649858
8654373
8945519
9130707
9374467
9393873
9405416
9628874
9732264
10021384
10230788
10349636
10498280
10559486
10674476
10922068
11042159
11076861
11157052
11217851
11358804
11423995
11435459
11466342
11562351
11920420
11927625
11927626
12147621
12223406
12376563
12447443
12466851
12486099
12689591
12697041
12756228
12857751
12897243
14517246
14578290
14633627
14657393
14704147
14704277
15013949
15102471
15123655
15272135
15350216
15375216
15528206
15566943
15567863
15572149
15572687
15673436
15767678
15778378
15805466
15816869
15867147
16043490
16081685
16113653
16141072
16141073
16217033
16314504
16466687
16514068
16571730
16579967
16606357
16627484
16818881
16973441
16973625
17056565
17143273
17167049
17202416
17301033
17301952
17337450
17365404
17400176
17449011
17644613
8817558
8889548
9806643
9878062
12445686
12559955
15504737
16641100
17333127
17555943
8177321
9651196

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 11
11 B1.2

OMIM ID 602896
OMIM:602896

Rat chromosome position 10q21
10q22

Hugo ID 6886
HGNC:6886

Human chromosome position 5q35.3
5q35

Swiss-Prot Accession P45984
D7R525
D7R526
P45984.2
Q8C094
Q9WTU6
Q5NCK8
Q9WTU6.2
D4A5V8
P49186
Q6P727
A0A0G2JYS4
P49186.1
A8K0S3
B5BU66
B5M0B4
D3DWQ8
D3DWQ9
Q15708
Q15710
Q15711
Q8N5C5
Q5NCK9
Q5NCL5
Q8C097
Q8VDD2
Q9WTU4
Q9WTU5
Q5NCK7
Q3V398
MK09_HUMAN

PIR ID A55480
S71102
S43968

GenBank ID NC_000005
NM_002752
NP_002743
NM_139070
NP_620709
NM_001364613
NP_001351542
NM_001364608
NP_001351537
NM_001364609
NP_001351538
NM_001364611
NP_001351540
NM_001364612
NP_001351541
NM_139068
NP_620707
NM_139069
NP_620708
NM_001364607
NP_001351536
XM_005265940
XP_005265997
XM_017009642
XP_016865131
NM_001135044
NP_001128516
NM_001364610
NP_001351539
XM_017009643
XP_016865132
NM_001308244
NP_001295173
NG_029059
AC008610
AC104115
CH471165
EAW53757
EAW53758
EAW53759
EAW53760
EAW53761
EAW53762
EAW53763
EAW53764
EAW53765
DQ066599
AAY46156
AB451302
BAG70116
AB451355
BAG70169
AB451433
BAG70247
AK289638
BAF82327
BC032539
AAH32539
BF056535
BQ025589
CR536580
CAG38817
CX758487
DB451562
EU927388
ACH57450
HM036706
ADH10365
HM036707
ADH10366
HM036708
ADH10367
HM036709
ADH10368
L31951
AAA56831
U09759
AAA74740
U34821
AAC50606
U35002
AAC50608
U35003
AAC50609
P45984
NC_000077
NM_016961
NP_058657
NM_001163671
NP_001157143
NM_001163672
NP_001157144
NM_207692
NP_997575
XM_017314563
XP_017170052
XM_017314562
XP_017170051
AJ315339
CAC88132
AJ315340
AJ315341
AJ315342
AJ315343
AJ315344
AJ315345
AJ315346
AJ315347
AJ315348
AJ315349
AJ315350
AL606479
CH466575
EDL33733
EDL33734
EDL33735
AB005664
BAA85876
AF052466
AAD22576
AF052467
AAD22577
AF052468
AAD22578
AF052469
AAD22579
AK031959
BAC27623
AK031974
BAC27634
AK043169
BAE43319
AK090057
AK145083
BAE26227
BB362351
BC024514
BC028341
AAH28341
CX235052
Q9WTU6
NC_005109
NM_001270544
NP_001257473
NM_001270545
NP_001257474
NM_017322
NP_059018
XM_017597479
XP_017452968
XM_006246318
XP_006246380
AC_000078
AABR07029576
AAHX01063750
CH473948
EDM04237
EDM04238
EDM04239
EDM04240
EDM04241
EDM04242
BC061870
AAH61870
BI282175
DN948189
FQ234999
L27111
AAA42108
L27112
AAA42109
P49186
XM_006714891
XP_006714954
XM_011534594
XP_011532896
NC_018916
AMYH02012903
DQ893713
ABM84639
EU176194
ABW03645
XM_006533379
XP_006533442
AC_000033
AAHY01093196
AAHY01093197
XM_006246317
XP_006246379
AC_000137
ABBA01010059
ABBA01010060
ABBA01010061
ABBA01010062
ABBA01010063
CAI23940
CAI23941
CAI23942
CAI23943
NT_023133
NW_922818
NW_001838967
AC_000048
CR612106
CR614221
CR619061
NT_096135
NW_001030461
Q3V398
Q5NCK7
Q5NCK8
Q8C094
NW_047334
NW_001084656
Q6P727
Q5NCK9
Q5NCL5
119574142
119574143
119574144
119574145
119574146
119574147
119574148
119574149
119574150
123994075
1463129
1463133
1463135
21618470
49168644
598183
607786
66394592
85700366
123792343
13124366
148701786
148701787
148701788
18254507
20306844
26327765
26327787
4558391
4558393
4558395
4558397
56205898
56205899
56205900
56205901
6141553
74203059
74217232
81886186
81886187
81886188
81886191
81913852
AW108403
BG068409
AI851083
1346338
149052420
149052421
149052422
149052423
149052424
149052425
38197448
493207
493209
81885302
Q8N5C5
NW_000039
NT_086684
122135977
86438360
AAI12748
BC112747
NC_007305
NM_001046369
NP_001039834
NW_001495309
Q2KI72
NC_007134
NW_001512526
XM_685934
XP_691026
AABR06063744

Swiss-Prot ID MK09_HUMAN
MK09_MOUSE
MK09_RAT
Q5NCK8_MOUSE
Q8C094_MOUSE
B5M0B4_HUMAN
Q5NCK7_MOUSE
A8K0S3_HUMAN
B5BU66_HUMAN
Q5NCK9_MOUSE
D3DWQ8_HUMAN
D3DWQ9_HUMAN

Cell Localization Cytoplasm
Nucleus
Plasma membrane

Ensembl ID ENSG00000050748
ENSP00000397422.2
ENST00000425491.6
ENSP00000443149.1
ENST00000539014.5
ENSP00000394560.2
ENST00000452135.6
ENSP00000377028.3
ENST00000393360.7
ENSP00000345524.6
ENST00000343111.10
ENSP00000389338.1
ENST00000455781.5
ENSMUSG00000020366
ENSMUSP00000136977.1
ENSMUST00000178543.7
ENSMUSP00000132864.1
ENSMUST00000164643.7
ENSMUSP00000104808.2
ENSMUST00000109179.8
ENSMUSP00000020634.7
ENSMUST00000020634.13
ENSRNOG00000002823
ENSRNOP00000004010.3
ENSRNOT00000004010.4
ENSRNOP00000003987.3
ENSRNOT00000003987.5
ENSRNOP00000070771.1
ENSRNOT00000083688.1
ENSP00000397422
ENST00000425491
ENSP00000394560
ENST00000452135
ENSP00000377028
ENST00000393360
ENSP00000345524
ENST00000343111
ENSP00000389338
ENST00000455781
ENSP00000443149
ENST00000539014
ENSMUSP00000136977
ENSMUST00000178543
ENSMUSP00000132864
ENSMUST00000164643
ENSMUSP00000104808
ENSMUST00000109179
ENSMUSP00000020634
ENSMUST00000020634
ENSRNOP00000004010
ENSRNOT00000004010
ENSRNOP00000003987
ENSRNOT00000003987
ENSRNOP00000070771
ENSRNOT00000083688

MGI ID MGI:1346862
1346862
1202396
2144306

RGD ID 628847

Unigene ID Hs.484371
Mm.68933
Rn.9910
Rn.177202
Hs.654461
Hs.348446
Bt.52287
Dr.34373

Homologene ID 55685

Shape Sickle-vertex

IPI ID IPI00191806
IPI00231634
IPI00024673
IPI00220382
IPI00220383
IPI00303550
IPI00123875
IPI00223339
IPI00223340
IPI00223342
IPI00913982
IPI00653963
IPI00777753

Microarray ID 101362_at
203218_at
1421877_at

Homo sapiens Chromosome position 5q35

Ensembl Transcript ID ENST00000393362
ENST00000347470
ENST00000343111
ENST00000393360

ENSEMBL ENSG00000050748

FunctionalClass ATP binding
JUN kinase
MAP kinase
nucleotide binding
protein binding
protein serine/threonine kinase
transferase
kinase
protein kinase
protein-tyrosine kinase
cAMP-dependent protein kinase
protein kinase CK2

Bos taurus Chromosome position 7

Mus musculus Chromosome position 11 B1.2
11
11 B1.3

KEGG pathway Adipocytokine signaling pathway
Colorectal cancer
ErbB signaling pathway
Fc epsilon RI signaling pathway
Focal adhesion
GnRH signaling pathway
Insulin signaling pathway
MAPK signaling pathway
Pancreatic cancer
Toll-like receptor signaling pathway
Type II diabetes mellitus
Wnt signaling pathway

Rattus norvegicus Chromosome position 10q22

Ensembl Gene ID ENSG00000050748

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: lymphoid tissue; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: breast; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: cells in granular layer; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: Purkinje cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cervix, uterine; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: colon; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: duodenum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: epididymis; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: fallopian tube; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: gall bladder; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: heart muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: neuronal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: kidney; Cell type: cells in glomeruli; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: kidney; Cell type: cells in tubules; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: bile duct cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: hepatocytes; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: macrophages; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: pneumocytes; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: ovary; Cell type: follicle cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: ovary; Cell type: ovarian stroma cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: islets of Langerhans; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: placenta; Cell type: decidual cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: placenta; Cell type: trophoblastic cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: prostate; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: rectum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: salivary gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: skeletal muscle; Cell type: myocytes; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: small intestine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: stomach, lower; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: stomach, upper; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: Leydig cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: thyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: urinary bladder; Cell type: urothelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: vagina; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: uterus
post-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: seminal vesicle; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain