Protein SOCS3

URN urn:agi-llid:9021
Total Entities 0
Connectivity 3359
Name SOCS3
Description suppressor of cytokine signaling 3
Notes This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm

Pathway Leptin and CCK8 Activate Nodose Ganglia Neuron
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Proteins Involved in Atherosclerosis
SOCS in Negative Feedback Regulation in Myocarditis
Proteins Involved in Melanoma
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Proteins Involved in Diabetes Mellitus Type 2
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Insulin Resistance in Hepatocytes
Thyroid Hormones in Adipose Tissue Metabolism
SOCS3 and PTPN1 in Hypothalamic Neuron Insensitivity to Insulin and Leptin
Proteins Involved in Obesity
Proteins Involved in Ulcerative Colitis
Proteins Involved in Follicular Lymphoma
TRPM7/8 in Pancreatic Adenocarcinoma
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
Proteins Involved in Glioblastoma
Proteins Involved in Endometriosis
IL10/STAT3 Signaling in M2 Macrophage and Retinal Angiogenesis
Proteins with Altered Expression in Age-Related Macular Degeneration
Alveolar Macrophage Negative Regulation Declined in COPD
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Epinephrine/Gq Expression Targets
CLCF1 Expression Targets
CCL15 Expression Targets
CSF3 Expression Targets
LIF Expression Targets
CNTF Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
GCG Expression Targets
ADCYAP1 Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
HBEGF -> STAT Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> AP-1/ATF Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> STAT Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
INHBA/ACVR2/BMPR Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
EGFR -> Expression Targets in Skin
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL21 Expression Targets
IL15 Expression Targets
IL6 Expression Targets
IL10 Expression Targets
IL22 Expression Targets
IL11 Expression Targets
IL9 Expression Targets
IL4 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Nerve Tissue
DLL4 Expression Targets
DLL1 Expression Targets
NOTCH Expression Targets
OSM/IL6ST/LIFR Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
AGT -> CREB Expression Targets
IFNA1/Gq Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
Elevated Receptors -> Expression Targets in Lung
Ras-GAP Regulation Signaling
AXL Receptor Tyrosine Kinase Signaling
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
TNF -> STAT Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> STAT Expression Targets
Thrombopoietin -> SP1 Expression Targets
TLR4 -> AP-1 Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> STAT Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
ace2
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of body weight
Neighbors of body weight gain
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of fibrosis progression
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of radioresistance
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of muscle mass
Neighbors of blood glucose
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of radiosensitivity
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of insulin level
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of body weight
Neighbors of body weight gain
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of fibrosis progression
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of radioresistance
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of muscle mass
Neighbors of blood glucose
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of radiosensitivity
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of insulin level
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of fibroblast proliferation
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of macrophage function
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of atherosclerotic plaque
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of interstitial fibrosis
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of synovitis
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of umbilical vein endothelial cell
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of pneumocyte
Neighbors of microglia
Neighbors of hepatocyte
Neighbors of dendritic cell
Neighbors of immunocompetent cell
Neighbors of myeloid cell
Neighbors of leukocyte
Neighbors of insulin-secreting cell
Neighbors of T-cell
Neighbors of retina cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of lymph node
Neighbors of placenta
Neighbors of lymphatic system
Neighbors of blastocyst
Neighbors of sympathetic nervous system
Neighbors of endocrine system
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of fibrinogen
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of endothelin
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of STAT5
Neighbors of ITG
Neighbors of CD3 complex
Neighbors of TLR1/2 heterodimer
Neighbors of TORC1
Neighbors of histone
Neighbors of neuropeptides
New Pathway (3)
1_Differentiation of psoriatic T cells
4_1_Polymorphisms associated with inflammatory bowel diseases
4_2_Insulin resistance: inflammation-related insulin resistance
Differentiation of psoriatic T cells

Group Genes Hypermethylated in Melanoma

MedScan ID 9021

LocusLink ID 9021
12702
89829

Alias E2a-Pbx1 target gene in fibroblasts 10
suppressor of cytokine signaling 3
STAT induced STAT inhibitor III
suppressor of cytokine signaling III
cytokine-inducible SH2 protein III
SSI-3
Dermatitis, atopic, 4
Dermatitis, atopic, IV
suppressor of cytokine inducible signaling 3
STAT induced STAT inhibitor 3
suppressor of cytokine signaling SOCS3
cytokine-induced SH2 protein III
SSI III
ATOD4
MGC71791
Ef10
RP23-268N22.6
SSI IIIs
OTTMUSP00000003963
cytokine-inducible SH2 protein 3
cytokine-induced SH2 protein 3
EF X
cytokine inducible sh2-containing protein 3
cytokine inducible sh2-containing protein III
SOCS3
CIS3
Cish3
SSI3
SOCS-3
STAT-induced STAT inhibitor 3
EF-10
CIS-3
suppressor of cytokine inducible signalling 3

GO ID 0046935
0001784
0004860
0007259
0060670
1990830
0019221
0070102
0035556
0046426
0043066
0050728
0046627
0006469
0042532
0046854
0060674
0045597
0042531
0043687
0016567
0040008
0060334
0043551
0060708
0060707
0005829
0005942
0009968
0045595
0001932
0007165
0005737
0007568
0031100
0001558
0009617
0034097
0042493
0032355
0032094
0010332
0051384
0009408
0009725
0001666
0032868
0032496
0014070
0043434
0032570
0042517
0005622
0060397
0060333
0060338
0060337
0007243
0006916

KEGG ID hsa:9021
mmu:12702
rno:89829

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 11

OMIM ID 604176
605805

Rat chromosome position 10q32.2
10q32.3

Hugo ID 19391
HGNC:19391

Human chromosome position 17q25.3

Swiss-Prot Accession O14543
Q6FI39
O14543.1
O35718
O35718.1
O88583
G3V6D2
O88583.1
O14509
P97803
Q3U7X5
Q9QYV5
B1AQL6
Q5U0H7
Q3U9J8

PIR ID JC5627
JC5761

GenBank ID NC_000017
NM_003955
NP_003946
NG_016851
AC061992
CH471099
EAW89521
EAW89522
AB004904
BAA22430
AB006967
BAA22537
AF159854
AAD42231
AK309756
AK314212
BAG36886
AU134017
BC060858
AAH60858
BE048635
BE245649
BT019544
AAV38351
CR536497
CAG38736
CR541694
CAG46495
DA671124
O14543
NC_000077
XM_011248707
XP_011247009
NM_007707
NP_031733
AF117732
AAD18024
AF314501
AAK60601
AL591433
CH466558
EDL34646
AK047165
BAC32977
AK139241
BAE23929
AK150719
BAE29797
AK151761
BAE30668
AK152441
BAE31222
AK152468
BAE31244
AK152514
BAE31277
AK152686
BAE31417
AK155097
AK157708
BAE34161
AK159395
BAE35049
AK170406
BAE41773
AK172399
BAE42985
BC052031
AAH52031
U72673
AAB51035
U88328
AAB62403
O35718
NC_005109
XM_008768398
XP_008766620
NM_053565
NP_446017
AC_000078
AABR07030870
AAHX01066870
AJ249240
CAB56083
CH473948
EDM06745
AF075383
AAC26223
O88583
NC_018928
AMYH02034054
AM392896
CAL37774
AM393146
CAL38024
AM393491
CAL38368
AC_000033
AAHY01096850
AC_000149
ABBA01002927
ABBA01002928
XM_006532110
XP_006532173
CAM19105
NT_010783
NW_926918
NW_001838455
AC_000060
CR602820
Q5U0H7
Q6FI39
NT_165773
NW_001030434
Q3U9J8
NW_001084656
NW_047344

Swiss-Prot ID SOCS3_HUMAN
SOCS3_MOUSE
SOCS3_RAT
B1AQL6_MOUSE
Q6FI39_HUMAN

Cell Localization Cytoplasm

Ensembl ID ENSG00000184557
ENSP00000330341.2
ENST00000330871.3
ENSMUSG00000053113
ENSMUSP00000059129.3
ENSMUST00000054002.3
ENSRNOG00000002946
ENSRNOP00000003940.1
ENSRNOT00000003940.3
ENSP00000330341
ENST00000330871
ENSMUSP00000059129
ENSMUST00000054002
ENSRNOP00000003940
ENSRNOT00000003940

MGI ID MGI:1201791
1201791

RGD ID 621087

Unigene ID Hs.527973
Hs.703620
Mm.3468
Rn.127801

Homologene ID 2941

IPI ID IPI00210797
IPI00297349
IPI00133840