Protein HIF1A

URN urn:agi-llid:3091
Total Entities 0
Connectivity 9987
Name HIF1A
Description hypoxia inducible factor 1 alpha subunit
Notes This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Androgen Deficiency in Male Obesity
Hypoxia Inhibits mTOR Signaling
SIRT6 Signaling in Aging
P-cell Activation
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Androgens in Adipocyte Activation
T-Cell Maturation (Hypothesis)
Mast-Cell Activation via IgE Signaling
Macrophage Related Iron Uptake and Release
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Adipokines Production by Adipocyte
IL1B Expression Targets -> Nociception
Circadian Clock in Sleep Regulation
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Hypoxia-Induced Pulmonary Hypertension
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Proteins with Altered Expression in Melanoma
Melanoma
MITF as a Regulator of Melanoma Cell Development
Proteins Involved in Melanoma
Melanocyte Role in Skin Aging
Peripheral Tissue Microangiopathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
Cardiovascular Effects in Hyperthyroidism
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
Peutz-Jeghers Syndrome
B-Cell Acute Lymphoblastic Leukemia
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Vascularization in Hepatocellular Carcinoma
Proteins Involved in Hepatocellular Carcinoma
WNT Signaling in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Goblet-Cell Related Mucus Secretion in Asthma
Mast-Cell Activation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Proteins Involved in Osteoarthritis
FXN Role in Friedreich Ataxia Progression
Proteins Involved in Epilepsy
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Neuroblastoma
Proteins Involved in Amyotrophic Lateral Sclerosis
Proteins Involved in Vascular Dementia
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Endometrial Cancer
Proteins Involved in Endometriosis
Clear Cell Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Proteins with Altered Expression in Ovarian Cancer
HPV Infection and Cancer
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
Androgen Receptor/c-Met Signaling in Prostate Cancer
FOXA2 Signaling in Prostate Cancer
Proteins Involved in Prostate Cancer
Netrin-1 Signaling in Age-Related Macular Degeneration
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
HIF1A in Pathologic Ocular Neovascularization
VEGFA in Neovascular Glaucoma
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Proteins with Altered Expression in Prostate Cancer
Endothelial Cell Dysfunction in Pyelonephritis
AREG -> HIF1A Expression Targets
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Elevated Receptors -> Expression Targets in Myocardium
CCL3 Expression Targets
CCL2 Expression Targets
EGF -> CTNN Expression Targets
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
EGFR/ERBB2 -> HIF1A Signaling
EREG -> HIF1A Expression Target
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
HBEGF -> HIF1A Expression Targets
HGF -> STAT Expression Targets
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
Apoptosis Block by Inhibitor of Apoptosis Proteins (IAPs) in Cancer
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
Suppression of Caspase Activity in Cancer
Apoptosis Evasion in Cancer: Overview
Hypoxia-Induced Cell Death Evasion in Cancer
Apoptosis Block by BCL2 Family Proteins in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
HIF1A as Master Regulator of Angiogenesis in Cancer
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
Metabolic Reprogramming in Cancer: Overview
Respiratory Chain Impairment in Cancer
Lactate as a Signaling Molecule in Cancer Cells
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
Mutations in Krebs Cycle Enzymes in Cancer
Glycolysis Activation in Cancer (Warburg Effect)
Proteins with Altered Expression in Cancer Metabolic Reprogramming
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Adenosine/cAMP Promote Immunosuppression by Treg Cells
EZH2 Methyltransferase Role in Cancer
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF2 -> STAT Expression Targets
IGF1 -> STAT Expression Targets
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
EGFR -> Expression Targets in Skin
NOTCH -> Expression Targets in Skin
IFNG/IFNR Expression Targets
IL3 Expression Targets
IL6 Expression Targets
Prostaglandin F Expression Targets
LPA Expression Targets
S1P Expression Targets
TNF Receptors -> Expression Targets in Lymphoid System and Blood
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1/Catenin Expression Targets
NRG1 -> STAT Expression Targets
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
Elevated Receptors -> Expression Targets in Nerve Tissue
BDNF Expression Targets
Adenosine Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
AGT -> CREB Expression Targets
TAC1 Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
CSF1 -> STAT Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
Elevated Receptors -> Expression Targets in Breast
HIF1 Signaling
TGFA -> HIF1A Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
TNF -> STAT Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> STAT Expression Targets
IL1B -> NO Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
Mitochondrial Damage Induced by Hypoxia
Elevated Receptors -> Expression Targets in Kidney
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
2_The role of endothelial cells in pyelonephritis
2_Podocyte dysfunction in glomerulonephritis
2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
3_Human papilloma virus E4 and E5 proteins in viral reproduction
1_Microangiopathy in diabetic neuropathy
drug-target pairs direct regulation
drug-target molsynthesis

Group Proteins Involved in Cowden Syndrome

MedScan ID 3091

LocusLink ID 3091
15251
29560

Alias bHLHe78
MOP I
hypoxia inducible factor 1, alpha subunit
PAS domain-containing protein 8
basic-helix-loop-helix-PAS protein MOP1
LOC115049
member of PAS superfamily I
HIF1alpha
ARNT interacting protein
AA959795
Hypoxia-inducible factor 1 alpha
hypoxia-inducible factor 1 alpha isoform I.3
class E basic helix-loop-helix protein 78
PASD8
OTTHUMP00000179063
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Hypoxia-inducible factor 1a
Member of PAS protein I
member of PAS protein 1
member of PAS superfamily 1
OTTMUSP00000021323
hypoxia inducible factor 1 subunit alpha
ARNT-interactive protein
ARNT interactive protein
HIF1A
hypoxia-inducible factor 1 DNA-binding subunit
member of PAS protein-1
ARNT-interacting protein
HIF1
MOP1
HIF-1A
HIF-1alpha
HIF1-ALPHA
HIF-1-alpha
hypoxia inducible factor 1 alpha subunit
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
hypoxia-inducible factor1alpha
hypoxia-inducible factor 1-alpha
HIF-1 alpha
HIF-1
HIF I
hypoxia-inducible factor 1
HIF1 alpha
hypoxia-inducible factor I

GO ID 0001228
0003700
0000981
0070888
0051879
0000977
0019899
0035035
0042826
0035257
0002039
0019904
0046982
0019901
0043565
0008134
0031625
0001922
0001525
0019896
0003208
0051216
0006879
0071456
0071347
0021987
0032963
0002248
0019221
0048546
0071542
0051541
0035162
0001892
0061030
0001837
0042593
0001947
0042541
0097411
0060574
0061072
0006089
0007595
0042789
0046716
0032007
0030502
0010629
0045926
2001054
1903377
2000378
0070244
0001755
0021502
0003151
0032364
0045766
1903599
0043536
0032722
0070101
0001938
0010634
0045648
0010628
0045821
0046886
0035774
0016239
0002052
0051000
1902895
0010870
0045944
0061419
0045893
0010575
0030949
0043687
0016579
0016567
1903715
0010468
0006357
0061418
0043619
0006355
0032909
0001666
0010039
0014850
0061298
0007165
0006366
0010573
0008542
0090575
1904115
0005737
0005829
0031514
0016604
0000790
0016607
0005654
0005634
0032991
0005667
0003677
0044877
0001568
0048514
0048593
0030154
0043066
0043524
0030279
0000122
0045906
0043065
0010508
0008284
0045722
0048661
0050790
0042127
0006110
0070243
0060992
0001944
0006953
0071245
0071279
1903928
0035690
0071257
0071333
0070301
0032869
0071482
0071396
0071222
0071260
0071250
0071407
0097237
0060135
0045793
1900037
0010165
0014823
0043279
0072347
0010996
0032025
0042493
0032355
0043627
0051384
0009749
0009612
0014074
0009651
0030424
0005623
0005515
0000989
0000988
0003690
0009434
0003705
0044212
0004871
0005730
0032403
0006351
0001077
0001076
0007219
0042981
0034244
0033554
2001141

KEGG ID hsa:3091
mmu:15251
rno:29560

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 12 31.99 cM
12 31.0 cM

OMIM ID 603348

Rat chromosome position 6q24

Hugo ID 4910
HGNC:4910

Human chromosome position 14q23.2

Swiss-Prot Accession Q16665
D0VY79
Q16665.1
Q61221
A0A0R4J1E9
Q3UCW2
Q61221.3
O35800
D4A8P8
O35800.1
C0LZJ3
Q53XP6
Q96PT9
Q9UPB1
O08741
O08993
Q61664
Q61665
Q8C681
Q8CC19
Q8CCB6
Q8R385
Q9CYA8
Q9WTU9
A8MYV6

PIR ID I38972
JC4837
JC5809

GenBank ID NC_000014
NM_001530
NP_001521
NM_181054
NP_851397
NM_001243084
NP_001230013
NG_029606
AF208487
AAF20149
AH006957
AAC68568
AL137129
CH471061
EAW80806
EAW80807
EAW80808
EAW80809
AB073325
BAB70608
AB500182
BAI49183
AB733094
BAM28632
AF207601
AAF20139
AF207602
AAF20140
AF304431
AAG43026
AJ227916
AK093749
AK296876
BAG59438
AK299551
BAG61496
AK304315
BAG65167
AK304436
BAG65259
AK312397
BAG35314
AU123241
BC012527
AAH12527
BT009776
AAP88778
BX648795
CN264295
CN264320
DC344032
DQ975378
FJ790247
ACN88547
U22431
AAC50152
U29165
AAC51210
X72726
Q16665
NC_000078
NM_001313920
NP_001300849
NM_001313919
NP_001300848
NM_010431
NP_034561
XM_006515478
XP_006515541
XM_017314961
XP_017170450
AC124712
AH006789
AAC53461
CH466526
EDL36500
EDL36501
U59496
AAC52730
Y09085
CAA70305
CAA70306
Y09086
Y13656
AF003695
AAC53455
AK008499
AK017853
BAB30975
AK033471
BAC28305
AK034087
BAC28578
AK048798
AK076395
BAC36320
AK138944
BAE23829
AK150367
BAE29500
BC026139
AAH26139
BY725437
CO810618
CX241289
X95002
CAA64458
X95580
CAA64833
Q61221
NC_005105
XM_006240196
XP_006240258
XM_006240197
XP_006240259
XM_006240198
XP_006240260
NM_024359
NP_077335
XM_006240199
XP_006240261
AC_000074
AAHX01045099
AC134165
CH473947
EDM03621
EDM03622
AF057308
AAD24413
FQ215710
Y09507
CAA70701
O35800
XM_005267573
XM_005267574
ABBA01018302
XP_006515540
XP_005267630
XP_005267631
AAHY01101338
AC_000146
XP_011242298
XP_011242299
AC_000034
AF004155
AF004153
AF004154
XM_008764695
NC_018925
XP_008762917
XM_011243996
XM_011243997
XM_006515477
AABR06044850
AF050115
AF050118
AF050119
AF004141
AF050116
AF050117
AMYH02029316
AF050121
AF004148
AF050122
AF004149
AF004146
AF050120
AF004147
AF050125
AF004144
AF050126
AF004145
AF050123
AF004142
AF050124
AF004143
AF004151
AF004152
AF050127
AF004150

Swiss-Prot ID HIF1A_HUMAN
HIF1A_MOUSE
HIF1A_RAT

Cell Localization Cytoplasm
Nucleus
Nucleus speckle

Ensembl ID ENSG00000100644
ENSP00000437955.1
ENST00000539097.2
ENSP00000338018.4
ENST00000337138.9
ENSP00000323326.6
ENST00000323441.10
ENSMUSG00000021109
ENSMUSP00000106088.1
ENSMUST00000110461.7
ENSMUSP00000021530.7
ENSMUST00000021530.7
ENSRNOG00000008292
ENSRNOP00000070177.1
ENSRNOT00000077935.1
ENSRNOP00000042230.3
ENSRNOT00000049725.3
ENSRNOP00000070177
ENST00000539097
ENST00000337138
ENSMUST00000110461
ENST00000337138.8
ENSP00000437955
ENST00000323441
ENSP00000323326
ENSMUSP00000021530
ENSMUSP00000106088
ENSRNOP00000042230
ENSMUST00000021530
ENSRNOT00000077935
ENSP00000338018
ENSP00000378446
ENST00000394997
ENSRNOT00000049725

MGI ID MGI:106918
106918

RGD ID 61928

Unigene ID Rn.10852
Hs.597216
Mm.3879
Hs.719495
Mm.397466
Mm.446610

Homologene ID 1171

Shape O-vertex

IPI ID IPI00406683
IPI00336700
IPI00951313
IPI00003442
IPI00332963