Pathway
|
Proteins Involved in Stem Cell Exhaustion in Aging
|
|
Alzheimer's Disease
|
|
Osteoarthritis
|
|
Skin Aging
|
|
Oncogene Induced Cellular Senescence
|
|
Melatonin Effects on Circadian Cycle
|
|
mTOR Signaling
|
|
mTOR Signaling Hyperfunction
|
|
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
|
|
Leptin and CCK8 Activate Nodose Ganglia Neuron
|
|
Insulin Influence on Glycogenesis
|
|
Insulin Synthesis in beta-Cell
|
|
Dopamine Receptors Signaling
|
|
Serotonin Receptors Signaling
|
|
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
|
|
Norepinephrine Release Regulation
|
|
CRH Secretion Regulation
|
|
Insulin Signaling
|
|
Prolactin Production
|
|
POMC Secretion in adenohypophysis
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
Mineralcorticoids Secretion Regulation
|
|
Toll-like Receptors Act through MYD88-TIRAP Signaling
|
|
TLR4 Signaling in Leukocytes
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Independent B-Cell Activation
|
|
V(D)J Recombination Activation
|
|
Natural Killer Cell Activation through C-Type Lectin-like Receptors
|
|
Natural Killer Cell Activation through ITAM-Containing Receptors
|
|
Natural Killer Cell Activation through ITSM-Containing Receptors
|
|
T-Cell Maturation (Hypothesis)
|
|
Natural Killer Cell Activation
|
|
CD8+ T-Cell Activation
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Plasmin Effects in Inflammation
|
|
Platelet Activation via Adhesion Molecules
|
|
Proplatelet Maturation
|
|
Platelet Activation via GPCR Signaling
|
|
Toll-like Receptors in Sterile Inflammation
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
Lipoxin A4/FPR2-Related Neutrophil Depression
|
|
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
|
|
MC1R in anti-Inflammatory Signaling
|
|
Eicosanoids in Myeloid Cell Activation
|
|
Leukotriene Effect on Airway Smooth Muscle Response
|
|
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Eosinophil Activation
|
|
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
Macrophage M1 Lineage
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
Macrophage M2-Related Phagocytosis
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
|
|
Neutrophil Recruitment and Priming
|
|
Neutrophil Activation via FCGR3B
|
|
Neutrophil Degranulation via FPR1 Signaling
|
|
Neutrophil Chemotaxis
|
|
Neutrophil Activation via Adherence on Endothelial Cells
|
|
Negative Acute Phase Proteins Synthesis
|
|
Positive Acute Phase Proteins Synthesis
|
|
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Potassium Flux Regulation
|
|
Nociception Expression Targets Signaling
|
|
Vascular Motility
|
|
NPY1R -> CRH/POMC Production
|
|
NTSR1 Expression Targets
|
|
EDNRA/B -> Vascular Motility
|
|
ADRA1 -> Vasoconstriction
|
|
ADRA1A -> IL6 Production
|
|
ADRA2C/ADRB2 -> Vasoconstriction
|
|
ADRA2C/ADRB2 -> Synaptic Endocytosis
|
|
ADRB1 -> Prostaglandin Generation
|
|
ADRA1 -> Prostaglandin Generation
|
|
BDKRB1/2 -> Prostaglandin Generation
|
|
CNR1/2 -> IL1B/2/4/6/10 Production
|
|
DRD2 Expression Targets
|
|
DRD1/5 Expression Targets
|
|
GALR1/2/3 -> POMC/NPY Production
|
|
HRH2/4 -> IL6/10 Production
|
|
CHRM1 -> IL2 Production
|
|
CHRM1/2/3 -> Vascular Motility
|
|
OPRK -> Pain Perception
|
|
PTGIR -> IL6 Production
|
|
PTGER1/4 -> Vascular Motility
|
|
PTGER2/3 -> Inflammation-Related Expression Targets
|
|
HTR1 -> IL6 Production
|
|
HTR7 -> IL6 Production
|
|
HTR5 -> TNF Production
|
|
HTR4/6/7 -> Cation Channels
|
|
IL6 Expression Targets -> Nociception
|
|
IL1B Expression Targets -> Nociception
|
|
CHRNA7 -> NOS1 Production
|
|
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
|
|
P2RY11/13/14 -> IL8/10 Production
|
|
Luteinizing Hormone in Oocyte Meiotic Resumption
|
|
Melatonin in Cell Survival and Antioxidant Response
|
|
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
|
|
Vitamine D Deficite and Dentin Formation
|
|
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
|
|
Cell Cycle Overiew
|
|
G0/G1 Phase Transition
|
|
Gap Junction Assembly
|
|
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
|
|
RAGE/AGER and S100 Proteins in Cardiovascular Injury
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Proteins Involved in Dilated Cardiomyopathy
|
|
Proteins Involved in Hypertrophic Cardiomyopathy
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Proteins Involved in Arterial Hypertension
|
|
Endothelin Signaling in Arterial Hypertension
|
|
Arterial Hypertension
|
|
Aldosterone Synthesis Acute Regulation
|
|
Endothelial Cell Dysfunction in Arterial Hypertension
|
|
Aldosterone Synthesis Chronic Regulation
|
|
Smooth Muscle Cell Dysfunction in Arterial Hypertension
|
|
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
|
|
Endothelial Cell Dysfunction in Pulmonary Hypertension
|
|
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
|
|
BMP2 and Canonical WNT Signaling in Pulmonary Artery Endothelial Cells
|
|
Myocardial Remodeling
|
|
Proteins Involved in Myocardial Ischemia
|
|
Proteins Involved in Myocarditis
|
|
Contraction Due Vasospasm
|
|
Sebocyte Proliferation in Acne Vulgaris
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Keratinocyte Proliferation in Acne Vulgaris
|
|
Hair Follicle Keratinocyte Apoptosis
|
|
Atopic Dermatitis Onset
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
Proteins with Altered Expression in Melanoma
|
|
Cell Cycle Dysregulation in Melanoma
|
|
Melanoma
|
|
Apoptosis Block in Melanoma Cell
|
|
MITF as a Regulator of Melanoma Cell Development
|
|
Proteins Involved in Melanoma
|
|
IL17 Signaling in Psoriasis
|
|
Proteins Involved in Psoriasis
|
|
IL22 Induces Keratinocyte Proliferation in Psoriasis
|
|
Proteins with Altered Expression in Psoriasis
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Apoptosis of Melanocyte in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
CD8+ T-Cell Response to Self-Determinants in Diabetes
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Toll-like Receptors in beta-Cell
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Donohue Syndrome Progression (Hypothesis)
|
|
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
|
|
Protein Kinase C in Diabetic Microangiopathy
|
|
Peripheral Tissue Microangiopathy
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
|
|
Proteins Involved in Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
Microangiopathy in Diabetic Neuropathy
|
|
Proliferative Diabetic Retinopathy
|
|
AGE Related Insulin Resistance in Skeletal Muscles
|
|
Proteins Involved in Insulin Resistance
|
|
Adiponectin Synthesis Declines in Insulin Resistance
|
|
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
|
|
Hyperparathyroidism, Neonatal Severe
|
|
RET1 Mutation in Hyperparathyroidism
|
|
Hypothyrodism Associated Hyperprolactinemia
|
|
DRD2 Pharmacological Inhibition in Hyperprolactinemia
|
|
Ethanol Induced Efects in Hyperprolactinemia
|
|
Bone Remodeling in Hyperthyroidism
|
|
Cardiovascular Effects in Hyperthyroidism
|
|
Thyroid Dysfunction
|
|
Graves Ophthalmopathy
|
|
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
|
|
Hypoparathyroidism, Primary
|
|
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
|
|
Overt Hypothyroidism, Primary
|
|
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
|
|
Proteins Involved in Obesity
|
|
Prolactinoma Overiew
|
|
CD4+T-Cell Response in Celiac Disease
|
|
CD8+ T-Cell Response in Celiac Disease
|
|
Celiac Disease
|
|
Proteins Involved in Colorectal Neoplasms
|
|
Metastatic Colorectal Cancer
|
|
GUCY2C Signaling in Colorectal Cancer
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
CagA Phosphorylation Dependent Signaling
|
|
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
|
|
Dendritic Cell Function in Ulcerative Colitis
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
FLT3/KIT/MLL Signaling in Leukemia
|
|
Acute Myeloid Leukemia
|
|
Myeloid Cell Differentiation Block in Leukemia
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Follicular Lymphoma
|
|
Proteins Involved in Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
Osteoclast Activation in Multiple Myeloma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Proteins Involved in Hepatocellular Carcinoma
|
|
Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Proteins Involved in Pancreatic Cancer
|
|
Pancreatic Ductal Carcinoma
|
|
Growth Factor Signaling in Pancreatic Neoplasms
|
|
Pancreatic Neuroendocrine Tumors
|
|
TRPM7/8 in Pancreatic Adenocarcinoma
|
|
TGFBR Signaling in Pancreatic Neoplasms
|
|
Eosinophil Survival in Asthma
|
|
Il17 Signaling Related Neutrophilia in Asthma
|
|
Eosinophil Activation and Degranulation in Asthma
|
|
IL17F Signaling in Bronchial Epithelial Cell in Asthma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Goblet-Cell Related Mucus Secretion in Asthma
|
|
Neutrophil Degranulation via FPR1/IL8
|
|
Antigen-Presenting Cell Role in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
Airway Epithelial Cell Dysfunction
|
|
Osteoclast Activation in Gout
|
|
Monocytes Function in Gout
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
IL1B Induced Arthralgia
|
|
Steroidogenesis Impairement in Polycystic Ovary Syndrome
|
|
Ovulation Block
|
|
Polycystic Ovary Syndrome
|
|
FSH Action in Polycystic Ovary Syndrome
|
|
Dendritic Cell Dysfunction in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
WHIM Syndrome
|
|
Dentin Formation Disruption
|
|
CCR5 Signaling in Macrophages
|
|
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
|
|
CD4+ T-Cell Function Decline in HIV
|
|
CD4+ T-Cell Death in HIV
|
|
Estrogen Effects on Pregnancy Gingivitis
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
Majeed Syndrome
|
|
Cowden Syndrome
|
|
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
|
|
Gluten Impact on Neuronal System (Hypothesis)
|
|
Proteins Involved in Autistic Disorder and Aggression
|
|
Muscular Dystrophies
|
|
IGF1 Role in Muscle Hypertrophy
|
|
Osteoblast Function Decline in Osteoporosis
|
|
Osteoclast Activation in Postmenopause
|
|
Proteins Involved in Epilepsy
|
|
BDNF Upregulation Triggered by Seizures
|
|
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
|
|
Glioblastoma, Primary
|
|
Proteins Involved in Glioblastoma
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Proteins Involved in Astrocytoma
|
|
Proteins Involved in Glioma
|
|
Proteins Involved in Medulloblastoma
|
|
Postsynaptic Neuron Activation
|
|
Prostaglandin E2 Synthesis Activation via Glutamate in Familial Hemiplegic Migraine
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
ALK Associated Neuroblastoma
|
|
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
|
|
Breast Cancer
|
|
ESR1 Signaling in Breast Cancer
|
|
Endometrial Cancer
|
|
Endometrioid Endometrial Cancer
|
|
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
|
|
Proteins Involved in Endometriosis
|
|
Angiogenesis in Endometriosis
|
|
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
|
|
Leptin Role in Endometriosis
|
|
Proteins Involved in Female Infertility
|
|
Proteins Involved in High-Grade Serous Ovarian Carcinoma
|
|
Endometrioid Ovarian Carcinoma
|
|
Proteins Involved in Endometrioid Ovarian Carcinoma
|
|
Clear Cell Ovarian Carcinoma
|
|
Proteins Involved in Mucinous Ovarian Carcinoma
|
|
EGFR and PTAFR Signaling in Ovarian Cancer
|
|
High-Grade Serous Ovarian Carcinoma
|
|
Low-Grade Serous Ovarian Carcinoma
|
|
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
|
|
Ovarian Cancer
|
|
Proteins Involved in Clear Cell Ovarian Carcinoma
|
|
Mucinous Ovarian Carcinoma
|
|
MIF Role in Cholesteatoma
|
|
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
HPV E4 Contribution to Life Cycle of Virus and Cell
|
|
Fatty Acid Synthase (FASN) Signaling
|
|
Androgen Receptor/FKBP5 Signaling
|
|
Prostate Cancer
|
|
RNase L Signaling in Prostate Cancer
|
|
TRPM8 Effects in Prostate Cancer (Hypothesis)
|
|
Proteins Involved in Prostate Cancer
|
|
Proteins Involved in Age-Related Macular Degeneration
|
|
Steroids Induced Cataract
|
|
VEGFA in Neovascular Glaucoma
|
|
Proteins Involved in Glaucoma
|
|
PGF2-alpha Effect on Treatment
|
|
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
|
|
Proteins Involved in Hearing Loss
|
|
Cytokines Trigger Otitis Media
|
|
MUC5AC Expression by NTHi and S. Pneumoniae
|
|
Immune System Role in Otitis Media
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Alveolar Macrophages Dysfunction in COPD
|
|
VEGFA Low Expression Level in Chronic Bronchitis
|
|
VEGFA High Expression Level in Pulmonary Emphysema
|
|
T-Cell Cytotoxic Activation
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
Polycystins Mutation Effects in Cystic Kidney Disease
|
|
Plasmin Role in Glomerulonephritis
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Mesangial Cell Dysfunction in Glomerulonephritis
|
|
Interstitial Fibroblasts in Pyelonephritis
|
|
Sertoli Cells Dysfunction Causes Male Infertility
|
|
Proteins Involved in Male Infertility
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
CD38 -> cADPR/Calcium Signaling
|
|
CD157 -> cADPR/Calcium Signaling
|
|
S100P Expression Target
|
|
HMGB1 Expression Targets
|
|
TTR Expression Targets
|
|
S100A Expression Targets
|
|
S100B Expression Targets
|
|
ANGPT1 -> CREB/CREBBP Expression Targets
|
|
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
|
|
AREG -> CREB/CREBBP Expression Targets
|
|
AREG -> SMAD1 Expression Target
|
|
AREG -> HIF1A Expression Targets
|
|
AREG -> AP-1 Expression Targets
|
|
Noradrenaline/Gs Expression Targets
|
|
Dopamine/Gs Expression Targets
|
|
Serotonin/Gs Expression Targets
|
|
Noreadrenaline/Gq Expression Targets
|
|
Epinephrine/Gs Expression Targets
|
|
Acetylcholine Expression Targets
|
|
Serotonin/Gq Expression Targets
|
|
Epinephrine/Gq Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
|
|
B-Cell Receptor -> AP-1 Signaling
|
|
BTC -> AP-1/ATF/CREB Expression Targets
|
|
BTC -> EP300/ETS/ETV/SP1 Expression Targets
|
|
GLP1R -> ARRB1 Signaling
|
|
IGF1R -> ARRB1/ERK1/3 Signaling
|
|
AGTR1 -> ARRB1/ARRB2 Signaling
|
|
SELE -> ELK-SRF Signaling
|
|
CD19 Expression Targets
|
|
CD81 -> AP-1 Expression Targets
|
|
CD247 Expression Targets
|
|
gamma Globulins Expression Targets
|
|
FCGR3A Expression Targets
|
|
CD19/CR2 Expression Targets
|
|
CD72 -> CREB/CREBBP Expression Targets
|
|
CD8 -> ATF/CREB/CREBBP Expression Targets
|
|
CD80 -> NF-kB Expression Targets
|
|
CD86 -> NF-kB Expression Targets
|
|
CXCL6 Expression Targets
|
|
CXCL1 Expression Targets
|
|
CXCL2 Expression Targets
|
|
CXCL3 Expression Targets
|
|
CXCL5 Expression Targets
|
|
CHRNA7 -> CREB Signaling
|
|
Clozapine Induced Granulocytopenia
|
|
EGF -> HIF1A Expression Targets
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
EGF -> TP53 Expression Targets
|
|
EGFR/ERBB2 -> TP53 Signaling
|
|
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
|
|
EGFR -> SMAD1 Signaling
|
|
EGFR/ERBB2 -> HIF1A Signaling
|
|
EGFR -> AP-1/ATF2 Signaling
|
|
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
|
|
EREG -> CREB Expression Target
|
|
EREG -> EP300/SP1 Expression Targets
|
|
EREG -> HIF1A Expression Target
|
|
EREG -> AP-1/ATF Expression Targets
|
|
Erythropoietin -> AP-1/MYC/CREB Expression Targets
|
|
Erythropoietin -> ELK/SRF Expression Targets
|
|
PECAM1 Expression Targets
|
|
NCAM1 Expression Targets
|
|
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
FGF9 -> AP-1/CREB/MYC Expression Targets
|
|
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
FGF7 -> RUNX Expression Targets
|
|
FGF8 -> AP-1/CREB/MYC Expression Targets
|
|
FGF1 -> RUNX Expression Targets
|
|
FGF18 -> AP-1/CREB Expression Targets
|
|
FGF8 -> RUNX Expression Targets
|
|
FGF9 -> RUNX Expression Targets
|
|
FGF4 -> AP-1/MYC Expression Targets
|
|
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> RUNX Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
FGFR -> RUNX2 Signaling
|
|
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
|
|
GCG Expression Targets
|
|
ADCYAP1 Expression Targets
|
|
FSHR Expression Targets
|
|
Glutamate/Gq Expression Targets
|
|
VIP Expression Targets
|
|
Elevated Receptors -> Expression Targets in Liver
|
|
EGFR -> Expression Targets in Colon
|
|
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
HBEGF -> AP-1/ATF Expression Targets
|
|
HBEGF -> TP53 Expression Targets
|
|
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
|
|
HBEGF -> HIF1A Expression Targets
|
|
HBEGF -> CREB/MYC Expression Targets
|
|
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
HGFR -> AP-1/CREB/MYC Signaling
|
|
TAM Receptor Signaling Activation in Cancer
|
|
G0/G1 Cell Cycle Phase Transition Activation in Cancer
|
|
RAS/RAF/MAPK Signaling Activation in Cancer
|
|
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
|
|
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
|
|
HIF1A in Vasculogenic Mimicry of Cancer
|
|
VEGFA Dependent Angiogenesis in Cancer
|
|
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
|
|
Integrins in Cancer Cell Motility, Invasion and Survival
|
|
Proteins with Altered Expression in Cancer Metastases
|
|
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
|
|
MTOR/TORC in Cancer Cell Motility and Invasion
|
|
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
|
|
CDH2 Activation Promotes Cancer Cell Migration and Survival
|
|
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
|
|
Lactate as a Signaling Molecule in Cancer Cells
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
EZH2 Methyltransferase Role in Cancer
|
|
HCAR1/HCAR2 -> MAPK Signaling
|
|
IGF2 -> HIF1A/MYC Expression Targets
|
|
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
AGER -> CREB/SP1 Signaling
|
|
NCAM1 -> CREB/ELK/SRF/MYC Signaling
|
|
CD19 -> JUN/ELK Signaling
|
|
PECAM -> SP1 Signaling
|
|
FcIgER -> ELK-SRF Signaling
|
|
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
|
|
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
|
|
InsulinR -> ELK/SRF/SREBF Signaling
|
|
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
|
|
Fibronectin Expression Targets
|
|
CTGF -> AP-1/CREB/MYC Expression Targets
|
|
ICAM1 Expression Targets
|
|
IL6R -> CEBP/ELK/SRF Signaling
|
|
IL2R -> ELK/SRF/MYC Signaling
|
|
IL1R -> NF-kB Signaling
|
|
IL4R -> ELK/SRF/HMGY Signaling
|
|
IL16 -> AP-1 Expression Targets
|
|
IL6 Expression Targets
|
|
IL4 Expression Targets
|
|
IL2 Expression Targets
|
|
UrokinaseR -> ELK/SRF Signaling
|
|
PTPRC -> BCL6 Expression Targets
|
|
Leptin -> ELK/SRF Expression Targets
|
|
Prostaglandin F Expression Targets
|
|
Thromboxane A2 Expression Targets
|
|
LPA Expression Targets
|
|
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
|
|
Dronabinol/Anandamide Expression Targets
|
|
Morphine Expression Targets
|
|
S1P Expression Targets
|
|
PGE1 Expression Targets
|
|
EGFR-> Expression Targets in Lymphoid System and Blood
|
|
MTNR1 Signaling
|
|
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
|
|
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
NRG1 -> TP53 Expression Target
|
|
NRG1 -> AP-1/ATF Expression Targets
|
|
NRG1 -> HIF1A Expression Target
|
|
NGF -> AP-1/TP53/MYC Expression Targets
|
|
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
NGF -> CREB/CEBPB/MEF2A Expression Targets
|
|
NOTCH -> TCF3 Signaling
|
|
NOTCH Expression Targets
|
|
Adenosine Expression Targets
|
|
OR1A1 -> GNAS Signaling
|
|
PDGFB -> AP-1/CREB/MYC Expression Target
|
|
PDGFC -> CREB Expression Target
|
|
PDGFD -> AP-1 Expression Targets
|
|
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
KIT -> MITF Signaling
|
|
PDGFR -> AP-1/MYC Signaling
|
|
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
GNRH1 Expression Targets
|
|
NTS Expression Targets
|
|
GAST Expression Targets in GAST Expression Targets
|
|
AGT -> TP53 Expression Targets
|
|
GNRH2 Expression Targets
|
|
OXT Expression Targets
|
|
POMC Expression Targets
|
|
CCL11 Expression Targets
|
|
EDN1 Expression Targets
|
|
AGT -> CREB Expression Targets
|
|
NPY Expression Targets
|
|
IFNA1/Gq Expression Targets
|
|
AGT -> ELK/SRF Expression Targets
|
|
TAC1 Expression Targets
|
|
EDN3 Expression Targets
|
|
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
|
|
PDCD1 -> NFATC Expression Targets
|
|
PDCD1 -> AP-1 Expression Targets
|
|
PTPRC -> BCL6 Signaling
|
|
AngiopoietinR -> AP-1 Signaling
|
|
GDNF -> HSF1 Signaling
|
|
EphrinB -> MAPK/JUN/FOS Signaling
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
GAS6 -> AP-1/CREB Expression Targets
|
|
FIGF -> AP-1 Expression Target
|
|
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
GDNF -> HSF1 Expression Targets
|
|
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
|
|
Lysophosphatidic Acid/LPARs Signaling
|
|
Ras-GRF Regulation Signaling
|
|
Androgen Receptor non-Genomic Signaling
|
|
FOXO1 Signaling
|
|
MERTK Signaling
|
|
Ras Signaling
|
|
TGF-beta Signaling
|
|
AMPK Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
VEGF Signaling
|
|
Estrogens/ESR1 non-Genomic Signaling
|
|
EGFR Signaling
|
|
ERK/MAPK Canonical Signaling
|
|
TCR -> AP-1 Expression Targets
|
|
T-Cell Receptor -> AP-1 Signaling
|
|
TGFA -> TP53 Expression Targets
|
|
TGFA -> HIF1A Expression Targets
|
|
TGFA/AP-1/ATF Expression Targets
|
|
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
|
|
FASLG Expression Targets
|
|
TNFSF10 Expression Targets
|
|
LTA Expression Targets
|
|
TNFSF14 Expression Targets
|
|
TNF -> AP-1 Expression Targets
|
|
CD72 -> AP-1 Expression Targets
|
|
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
|
|
TNFSF13 Expression Targets
|
|
TNFSF13B Expression Targets
|
|
TNF -> ELK-SRF Expression Targets
|
|
TNF -> CREB Expression Targets
|
|
TNF -> TP53/ATF Expression Targets
|
|
EDA Expression Targets
|
|
EctodysplasinR -> AP-1 Signaling
|
|
TNFR -> CREB/ELK-SRF Signaling
|
|
TNFR -> AP-1/ATF/TP53 Signaling
|
|
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
|
|
TNFRSF6 -> HSF1 Signaling
|
|
TNFRSF1A -> AP-1/ATF/TP53 Signaling
|
|
TNFRSF1A -> CREB/ELK-SRF Signaling
|
|
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
Thrombopoietin -> SP1 Expression Targets
|
|
IL1B -> NO Expression Targets
|
|
IL1B -> PGE2 Expression Targets
|
|
IL1B Expression Targets
|
|
IL1A Expression Targets
|
|
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
|
|
PLAU -> ELK-SRF/AP-1 Expression Targets
|
|
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
|
|
VEGFC -> ATF Expression Target
|
|
VEGFA -> AP-1/CREBBP/MYC Expression Targets
|
|
VEGFR -> AP-1/CREB/MYC Signaling
|
|
VEGFR -> ATF/CREB/ELK-SRF Signaling
|
|
pathway 3
|
|
e
|
|
ace2
|
|
pprarg neg, uknown targets, ps-positive
|
|
Model of PPARG signaling in psoriasis
|
|
Model of PPARG related pathways in psoriasis (short version)
|
|
1_Inflammation in keratinocytes in the pathology of acne
|
|
2_Hyperseborrhea in acne vulgaris
|
|
2_Acute phase initiation in atopic dermatitis
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
1_The onset of atopic dermatitis
|
|
1_TNF and IL1B provoke ECM degradation in osteoarthritis
|
|
2_Osteoblast-mediated bone demineralization
|
|
1_Formation of cysts in polycystic kidney disease
|
|
2_The role of endothelial cells in pyelonephritis
|
|
3_The role of interstitial fibroblasts in pyelonephritis
|
|
1_Local estrogen production stimulates ectopic endometrium proliferation
|
|
3_Enhanced angiogenesis in endometriosis
|
|
2_Impaired steroidogenesis in PCOS
|
|
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
|
|
2_Pathogens stimulate mucins expression in the middle ear
|
|
3_Arterial wall inflammation and calcification in atherosclerosis
|
|
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
|
|
2_Cardiomyocyte hypertrophy
|
|
3_Dysfunction of smooth muscle cells in hypertension
|
|
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
|
|
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
|
|
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
|
|
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
|
|
1_Th2 cell response in asthma
|
|
3_1_Mucus accumulation in asthma
|
|
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
|
|
4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
1_CD4+ T cell and epithelial cell response in celiac disease
|
|
2_CD8+ T-cell response and mucosal damage in celiac disease
|
|
3_Human papilloma virus E4 and E5 proteins in viral reproduction
|
|
1_1_Insulin synthesis and secretion: insulin processing and storage
|
|
4_1_Insulin resistance: insulin signaling
|
|
3_Islet beta-cell destruction in T1D
|
|
1_Microangiopathy in diabetic neuropathy
|
|
2_1_General pathways of thyroid hormone signaling
|
|
drug-target molsynthesis
|
|
Model of PPARG signaling in psoriais (tested)
|
|
public list
|
|
New Pathway
|
|
HRAS->RAF->MAPK1/3
|
|
KRAS->RAFs->MAPK1/3
|
|
NRAS->RAFs->MAPK1/3
|
|
Other RASs-RAFs-MAPK1/3
|
|
mapk1
|
|
New Pathway
|
|
mapk1 direct regulators
|
|
mapk1 protein modificators
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|