URN | urn:agi-llid:8862 |
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Total Entities | 3 |
Connectivity | 2082 |
Name | APLN |
Description | apelin |
Notes | This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016] |
Primary Cell Localization | Extracellular |
Class | Ligand |
ChildConcepts | apelin-36 |
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apelin-17 | |
apelin-13 |
Pathway | Adipokines Production by Adipocyte |
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Proteins Involved in Atherosclerosis | |
Proteins Involved in Dilated Cardiomyopathy | |
Proteins Involved in Arterial Hypertension | |
Proteins Involved in Pulmonary Hypertension | |
Proteins Involved in Myocardial Ischemia | |
Proteins Involved in Polycystic Ovary Syndrome | |
Proteins Involved in Epilepsy | |
Proteins Involved in Amyotrophic Lateral Sclerosis | |
GH1/GHR -> STAT Expression Targets | |
GH1/PRLR Expression Targets | |
Model of PPARG signaling in psoriasis | |
drug-target moltransport |
Group | Genes with Mutations Associated with Obesity |
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MedScan ID | 8862 |
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LocusLink ID | 8862 |
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30878 | |
58812 |
Alias | peptide ligand for APJ receptor |
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peptide ligand for APJ receptors | |
AGTRL1 ligand | |
RP23-455F14.1 | |
6030430G11 | |
APLN | |
6030430G11Rik | |
APJ endogenous ligand | |
UNQ471 | |
apelin, peptide ligand for APJ receptor | |
apelin, AGTRL1 ligand | |
apelin, peptide ligand for APJ receptors | |
Apel | |
apelin | |
OTTMUSP00000019097 | |
RIKEN cDNA 6030430G11 gene | |
preproapelin | |
XNPEP2 |
GO ID | 0031704 |
---|---|
0005179 | |
0042803 | |
0005102 | |
0007186 | |
0001525 | |
0060183 | |
0060976 | |
0042756 | |
0007369 | |
0006955 | |
0007595 | |
0045776 | |
0040037 | |
0010629 | |
1904706 | |
0045906 | |
1904022 | |
0051461 | |
0051466 | |
0045823 | |
0031652 | |
0042327 | |
1902895 | |
1905564 | |
0043576 | |
0002026 | |
0007165 | |
0005576 | |
0005615 | |
0048471 | |
0007631 | |
0007275 | |
0097755 | |
0008284 | |
0050878 | |
0010469 |
KEGG ID | hsa:8862 |
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mmu:30878 | |
rno:58812 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | X |
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OMIM ID | 300297 |
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Rat chromosome position | Xq36 |
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Hugo ID | 16665 |
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Human chromosome position | Xq26.1 |
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Swiss-Prot Accession | Q9ULZ1 |
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Q9ULZ1.1 | |
Q544B5 | |
Q9R0R4 | |
Q9R0R4.1 | |
Q9R0R3 | |
Q9R0R3.1 | |
Q4VY08 | |
Q8WU89 |
Swiss-Prot ID | APEL_HUMAN |
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APEL_MOUSE | |
APEL_RAT |
Cell Localization | Secreted |
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Extracellular space |
Ensembl ID | ENSG00000171388 |
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ENSP00000391800.2 | |
ENST00000429967.3 | |
ENSMUSG00000037010 | |
ENSMUSP00000046012.7 | |
ENSMUST00000039026.7 | |
ENSRNOG00000003984 | |
ENSRNOP00000005331.3 | |
ENSRNOT00000005331.5 |
MGI ID | MGI:1353624 |
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RGD ID | 620672 |
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