Protein TGFB1

URN urn:agi-llid:7040
Total Entities 1
Connectivity 20167
Name TGFB1
Description TGFB1
Notes This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

ChildConcepts latency-associated peptide

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Prolactin Production
Cortisol in Resolving Inflammation
Estrogens in Prolactin Production
TLR4 Signaling in Leukocytes
Immunoglobulin Class-Switch Recombination Activation
Treg-Cell Differentiation
AHR Signaling in Treg and Dendritic Cells Function
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
Plasmin Effects in Inflammation
Proplatelet Maturation
Lipoxins and Resolvins in Inflammation Resolution
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
anti-Inflammatory Function of Macrophage M2 Lineage
Vascular Endothelial Cell Activation by Growth Factors
Vascular Smooth Muscle Cell/Pericyte Differentiation and Proliferation
PRL Expression Regulation by BMP4 and TGFB1
G1/S Damage Checkpoint
Cell Cycle Overiew
Proteins Involved in Atherosclerosis
Dilated Cardiomyopathy
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Pulmonary Hypertension
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension
Proteins Involved in Hypoxia-Induced Pulmonary Hypertension
Myocardial Remodeling
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Hair Follicle Keratinocyte Apoptosis
Androgens in Sebocyte Maturation
Proteins Involved in Androgenetic Alopecia
Androgens Promote Scalp Dermal Papilla Regression
Proteins with Altered Expression in Androgenetic Alopecia
Proteins with Altered Expression in Melanoma
Melanoma
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
TGF-beta Signaling in Skin Aging
Proteins Involved in Systemic Lupus Erythematosus
Proteins Involved in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Proteins Involved in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Proteins Involved in Diabetes Mellitus Type 2
Hexosamine Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
Immune Sustem Activation in Hashimoto's Thyroiditis
Proteins Involved in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
Ethanol Induced Efects in Hyperprolactinemia
Graves Ophthalmopathy
Proteins Involved in Myasthenia Gravis
Proteins Involved in Obesity
Proteins Involved in Prolactinoma
Proteins Involved in Celiac Disease
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
GUCY2C Signaling in Colorectal Cancer
Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
Proteins Involved in Ulcerative Colitis
Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Proteins Involved in Diffuse Large-B-Cell Lymphoma
Proteins Involved in Follicular Lymphoma
Hodgkin and Reed-Sternberg Cells in Hodgkin Lymphoma
Proteins Involved in Hodgkin Lymphoma
Hodgkin Lymphoma
Proteins Involved in Multiple Myeloma
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
SERPINA1 Associated Pulmonary Emphysema
Vascularization in Hepatocellular Carcinoma
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
ADAM33 Role in Asthma
Eosinophil Survival in Asthma
Th17-Cell Differentiation in Asthma
Proteins Involved in Cystic Fibrosis
Proteins Involved in Osteoarthritis
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
Proteins with Altered Expression in Systemic Scleroderma
Proteins Involved in HIV Type 1 Infection
Th17-Cell Numbers Reduction in HIV
CD4+ T-Cell Function Decline in HIV
Proteins Involved in Periodontitis
Hereditary Hemorrhagic Telangiectasia
Proteins Involved in Hereditary Hemorrhagic Telangiectasia
Proteins Involved in Autistic Disorder
Proteins Involved in Autistic Disorder and Aggression
Proteins Involved in Hutchinson-Gilford Progeria Sindrome
Muscular Dystrophies
Proteins Involved in Osteoporosis
Proteins with Altered Expression in Rheumatoid Arthritis
Proteins Involved in Alzheimer's Disease
Proteins Involved in Glioblastoma
Proteins Involved in Ependymoma
Proteins Involved in Glioma
Glioma Stem Cell Program Activation
Medulloblastoma
Proteins Involved in Medulloblastoma
Proteins Involved in Migraine
Proteins Involved in Amyotrophic Lateral Sclerosis
Proteins Involved in Multiple Sclerosis
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Breast Cancer
Proteins Involved in Endometriosis
Proteins Involved in Spontaneous Abortion
Ovarian Cancer
Proteins with Altered Expression in Ovarian Cancer
Proteins Involved in Cholesteatoma
Proteins Involved in HPV Infection
Prostate Cancer
Proteins Involved in Prostate Cancer
Proteins Involved in Age-Related Macular Degeneration
Proteins Involved in Cataract
Steroids Induced Cataract
MYOC Associated Glaucoma
Proteins Involved in Glaucoma
Cochlear Inflammation (Noise-Induced)
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
Alveolar Epithelial Cell Dysfunction in COPD
Proteins Involved in Pulmonary Emphysema
Proteins Involved in Chronic Bronchitis
Genes with Mutations Associated with Cystic Fibrosis
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
Proteins with Altered Expression in Erectile Dysfunction
Proteins Involved in Erectile Dysfunction
Proteins Involved in Glomerulonephritis
Proteins with Altered Expression in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Proteins with Altered Expression in Pyelonephritis
Proteins Involved in Cryptorchidism
S100B Expression Targets
Dopamine/Gi Expression Targets
BMP2/BMPR2 Expression Targets
BMP7/ACVR2 Expression Targets
BMP4/BMPR2 Expression Targets
BMP7/BMPR2/ACVR2 Expression Targets
TGFBR3 -> ARRB2 Signaling
CD19 Expression Targets
CD86 -> ATF/CREB/CREBBP Expression Targets
CD86 -> STAT Expression Targets
CD86 -> NF-kB Expression Targets
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Blood Vessel
CCL3L1 Expression Target
CCL15 Expression Targets
CSF3 Expression Targets
CSF2 -> STAT Expression Targets
CNTF Expression Targets
Ethanol Induced Hepatotoxicity
Cyclosporine Induced Nephrotoxicity
Elevated Receptors -> Expression Targets in Pancreas
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF2 -> STAT Expression Targets
FGF9 -> STAT Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
GCG Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
DNA Damage Checkpoint Impairment in Cancer
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
IL12 Antitumor Effect is Blocked in Cancer
Proteins with Altered Expression in Tumor-Promoting Inflammation
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
Inhibition of THBS1 Activates Angiogenesis in Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Invadopodia Formation in Cancer Cells
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
MHC1 Causes Antigen Presentation Failure in Cancer Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
INHBA/ACVR2/BMPR Expression Targets
INHBA/ACVR2/ACVR1 Expression Targets
ICAM1 Expression Targets
Fibrinogen Expression Targets
NOTCH -> Expression Targets in Skin
IL13 Expression Targets
IL3 Expression Targets
IL5 Expression Targets
IL9 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
TNF Receptors -> Expression Targets in Lymphoid System and Blood
CD40 -> Expression Targets in Thymus
CD40 -> Expression Targets in Lymph Node
Elevated Receptors -> Expression Targets in Thymus
P2RX7 -> Expression Targets in Nerve Tissue
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NTF3 Expression Targets
Adenosine Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
POMC Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
AVP/Gq -> STAT Expression Targets
TAC1 Expression Targets
AVP/Gs -> STAT Expression Targets
AGT -> STAT Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
MDK/PTN Expression Targets
PAF Expression Targets
TGFBR -> AP-1 Signaling
TGFBR/BMPR -> SMAD2/3 Signaling
TGFBR -> CREB/ELK-SRF Signaling
TGFBR -> ATF/GADD/MAX/TP53 Signaling
TGFBR -> SMAD1/5/9 Signaling
TGFBR -> MEF/MYOD/MYOG Signaling
TGFBR1/AP-1 Signaling
MSTN/ACVR2/ACVR1 Expression Targets
NODAL/ACVR2B Expression Targets
Elevated Receptors -> Expression Targets in Lung
TGF-beta Signaling
TCR -> NF-kB Expression Targets
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
TNF -> STAT Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> STAT Expression Targets
TLR7 Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
Elevated Receptors -> Expression Targets in Kidney
cypa
PPAR Psoriasis
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of aortic smooth muscle cell
Neighbors of hematopoietic cell
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of carotid artery
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of artery
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of lymphatic system
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of allantois
Neighbors of alveolus
Neighbors of coronary artery
Neighbors of left ventricle
Neighbors of uterine cervix
Neighbors of omentum
Neighbors of arteriole
Neighbors of bronchus
Neighbors of glands
Neighbors of nose
Neighbors of eye
Neighbors of cornea
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of lymph node of mesentery
Neighbors of mammary gland
Neighbors of vagina
Neighbors of vitreous body
Neighbors of cerebral cortex
Neighbors of bladder
Neighbors of draining lymph node
Neighbors of nervous system
Neighbors of blastocyst
Neighbors of nasopharynx
Neighbors of periodontal ligament
Neighbors of trachea
Neighbors of nerve
Neighbors of endocrine system
Neighbors of small intestine
Neighbors of aggregated lymphoid follicle of small intestine
Neighbors of lymphatic vessels
Neighbors of mediastinal lymph node group
Neighbors of left atrium
Neighbors of hypothalamus
Neighbors of choroid plexus
Neighbors of hair follicle
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of HIF-1
Neighbors of IL12
Neighbors of Notch
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of STAT5
Neighbors of vitronectin receptor (integrin)
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of relaxin
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of adrenoceptor
Neighbors of TLR4/Myd88
Neighbors of TNF-alpha receptor
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
sars-cov no binding
Overview. Diseases of the skin (chapter 11)
Overview. Diseases of the respiratory (chapter 9)
Overview. Diseases of the genitourinary system (chapter 13)
1_Differentiation of psoriatic T cells
3_TGFB signaling provokes endochondral ossification with osteophyte formation
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
2_Podocyte dysfunction in glomerulonephritis
2_MYOC-associated glaucoma
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
2_Cardiomyocyte hypertrophy
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_1_Polymorphisms associated with inflammatory bowel diseases
1_2_Feedback relations between coagulation and fibrinolysis
1_SERPINA1-associated pulmonary emphysema
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Defective tolerance of autoreactive T-cell in T1D
1_Microangiopathy in diabetic neuropathy
drug-target moltransport
drug-target molsynthesis
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atherosclerosis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Obesity
Genes with Mutations Associated with Cystic Fibrosis
Genes with Mutations Associated with Systemic Scleroderma
Genes with Polymorphisms Associated with Migraine
Genes with Mutations Associated with Endometriosis
Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis
other partners for SARS

Source Pathway Studio Ontology
curated
GO component
ResNet

MedScan ID 7040

LocusLink ID 7040
21803
59086
43846
282089
359834
337700

Alias TGF eta
TGF-beta 1
TGF1_RAT
tumor growth factor beta
tumor growth factor beta 1
transforming growth factor beta 1
TGF-beta I
trans-forming growth factor beta
transforming growth b1
TGF1_HUMAN
TGFB1
IBDIMDE
tumor growth factor-b
Tgfb I
trans-forming growth factor beta 1
TGFB
Camurati-Engelmann disease protein
tumor growth factor b-1
TGF beta
transforming growth factor (TGF)-beta
TGF-B1
beta 1 transforming growth factor
Camurati-Engelmann disease gene
prepro-transforming growth factor beta-1
transforming growth factor beta
CED
LAP
DPD1
TGFbeta
TGF-beta-1
latency-associated peptide
transforming growth factor beta-1 proprotein
Tgfb-1
TGFbeta1
TGF-beta1
transforming growth factor beta-1
tumour growth factor beta
transforming growth factor, beta-1
regulatory protein
transforming growth factor-beta 1
TGF-beta 1 protein
transforming growth factor, beta
diaphyseal dysplasia 1, progressive
DPD I
Transforming growth factor beta 1 precursor
transforming growth factor, beta 1
transforming growth factor, beta 1 (Camurati-Engelmann disease)
diaphyseal dysplasia 1, progressive (Camurati-Engelmann disease)
Camurati-Engelmann disease
diaphyseal dysplasia 1
diaphyseal dysplasia I
beta 1 (Camurati-Engelmann disease)
transforming growth factor beta-1 precursor
TGF1
HGNC:2997
wu:fb13a07
xx:ai39657
ai39657
beta 1
chromosome
scaffold
transforming growth factor

GO ID 0003823
0005125
0019899
0008083
0047485
0046982
0042803
0043539
0005160
0034713
0005114
0034714
0006754
0000165
0007219
0007183
0060395
0043029
0002460
0007568
0003180
0060751
0007050
0048468
0016477
0045216
0006874
0071549
1990314
0071479
0071260
0071407
0071560
0002062
0007182
0002248
0019221
0009817
0048565
1990402
0007492
0007173
0001837
0019049
0085029
0097191
0060325
0007565
0060364
0008354
0007507
0003179
0002244
0030214
0006954
0048839
0070306
0050900
0031663
0097421
0048535
0010742
0060744
0031293
0007093
0032943
0046716
0042552
0043011
0042130
0070168
0043537
0045786
0045596
0030308
0008285
0022408
0045918
0050680
0010716
0045599
0010629
0060965
1900126
0032700
0010936
0045930
0045662
0007406
0030279
0050765
1903799
1903077
0001933
0051280
0048642
0000122
0045892
0030512
0001843
0021915
0014003
0043932
0030316
0060389
0006796
0002576
0070374
0043406
1901666
0051092
0060391
0043065
0043536
0030501
0090190
2000727
0071158
0051781
0030335
0008284
0032270
0050921
0032967
0050679
0010718
0031536
1901203
0010763
0048146
0010628
0035066
0031065
0032740
0048298
0014008
0071677
0042482
0010862
0033138
0010800
0050731
0043552
1902895
1903800
0031334
0035307
0042307
0051897
1900182
0001934
0050714
1903911
0045591
0051152
0032930
0045944
2000679
0045893
0010575
0043117
0006611
0043491
0006468
0032801
0051101
0043408
0060390
2000249
0042981
0051098
0060312
0060762
0061035
0030334
0042127
1905005
0032667
1902893
0042306
0002028
0016202
0017015
0045066
0070723
0032355
0009749
0001666
0035902
0034616
0032570
1902074
0033280
0009611
0007435
0002513
0007179
1905313
0001657
0001570
0055010
0005796
0030424
0072562
0009986
0062023
0005737
0031012
0005576
0005615
0005902
0043025
0005634
0005886
0031093
0002362
0042110
0030217
0072540
0009887
0031100
0001775
0008283
0071363
0061448
0006952
0030879
0001763
0050868
0050777
0032829
0010468
0045589
0010033
0007519
0001501
0042060
0030141
0030324
0001558
0010469
0042493
0014070
0009314
0000060
0001948
0007184
0046732
0016049
0008156
0005578
0040007
0007596
0030198
0019048
0030168
2000628
0019058
0005623
0009790
0008219
0043499
0006917
0031575
0016563
0043193
0010552
0051789
0071445
0016481
0042476
0005515
0045595
0006916
0000074
0007267
0046888
0003677
0006306
0008170
0007515
0008220
0007275
0045941

KEGG ID hsa:7040
mmu:21803
rno:59086

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12775566
12787424
12794244
12795790
12802498
12810668
1281686
12817760
12821938
12824005
12838101
12843182
12850832
12857600
12858451
12874450
12875973
12879019
12879228
12893825
12894997
12898374
12902338
12911534
12911563
12917425
12938093
12943995
12953061
12960355
13679381
14504277
14504444
14507446
14510802
14514699
14525983
14529885
14531804
14576166
14576954
14583433
14585325
14595120
14600158
14607563
14607699
14612931
14614718
14633126
14634021
14635011
14636845
14637150
14642613
14644155
14667198
14672557
14675189
14676209
14712482
14720431
14722617
14737114
14751563
14755254
14757763
14976204
14988407
14991065
14993265
15000149
15001984
15003992
15009180
15018667
15033015
15033492
15034041
15034927
15044465
15044491
15057277
15066699
15068691
15086490
15100259
15102678
15102771
15113633
15114294
15132952
15133024
15133032
15159307
15166495
15170816
15175276
15178409
15180953
15184872
15187087
15187109
15191521
15192088
15200451
15203191
15212689
15219857
15220111
15221033
15225617
15231647
15240008
15247230
15248227
15269821
15271980
15284289
15294900
15297631
15308875
15316224
15334054
15337504
15353478
15354859
15359164
15361357
15365652
15368517
15372625
15373772
15377500
15387373
15450129
15467747
15488704
15494412
15498571
15498766
1550960
15522940
15536170
15539010
15546338
15569360
15574511
15593052
15593053
15596839
15598443
15599946
15604209
15609398
15613484
15623538
15632190
15637079
15641096
15654963
15661045
15665522
15671065
15702480
15703175
15705190
15716278
15730046
15732863
15735739
15738684
15754021
15763337
15767424
15770661
15777850
15778389
15778431
15788474
15794197
15799969
15800982
15802940
15803361
15811853
15818397
15843517
15848527
15854667
15856020
15860935
15880049
15881652
15895394
15905358
15913806
15913903
15917723
15927846
15935652
15935832
15941661
15942255
15945506
15946939
15951295
15951665
15955247
15957132
15982639
16003239
16014625
16044414
16046050
16046504
16055706
16082716
16086840
16095497
16098131
16100012
16111879
16113310
16135802
16135988
16144297
16146757
16158060
16179583
16179826
16184401
16187293
16187311
16207846
16209640
16210002
16219695
16222707
16223572
16223775
16245329
16251192
16253118
16253647
16258727
16258965
16259606
16270194
16277007
16285938
16292494
16301119
16307809
16324212
16330131
16336267
16343799
16367920
16378061
16378062
16387180
16400883
16403803
16407286
16412560
16413503
16414983
16423881
16428771
16467160
16482098
16488890
16495290
16496359
16499994
16504679
16521228
16541418
16543220
16552334
16563223
16563228
16571622
16617095
16619041
16621788
16622033
16637060
16646981
16675485
16675963
16677601
16685022
16690986
16698802
16704689
16718633
16720864
16730947
16732186
16733295
16754688
16792132
16799085
16807529
16815840
16820791
16820871
16824504
16828470
16835828
16837650
16843825
16849317
16873204
16877343
16920945
16921482
16933058
16934609
16962935
16969385
16980081
16987065
16987066
16990569
16998703
17003485
17044077
17052957
17067743
17072955
17074098
17080483
17088559
17097497
17100549
17114344
3470709
3487831
3861940
7638106
7686157
7695626
7798269
7803268
7935686
8093006
8235612
8264131
8294518
8336945
8568261
8599089
8617200
9383706
9434787
9521216
9660815
9670843
9813058
9918798
9987082
11062463
11746498
12202987
14679171
15489334
16133992
16263699
16335952
16369764
16423922
16564125
16712948
16754747
16828225
16896935
16904244
16971953
17014924
17023741
17032917
17035229
17076676
17137775
17139467
17145161
17146441
17151785
17164348
17187359
17194537
17198270
17203972
17205957
17209781
17217620
17230494
17234915
17242066
17261758
17268554
17277740
17285762
17288590
17290010
17292826
17305717
17312920
17314099
17319955
17325209
17327236
17332318
17338374
17341608
17341610
17341683
17346099
17347580
17359969
17360530
17360654
17365852
17367219
17368597
17369289
17371954
17376051
17376924
17381064
17382930
17392271
17401617
17404043
17405902
17409139
17415413
17417945
17418380
17418594
17424886
17433803
17438144
17459720
17468136
17469184
17483238
17485238
17486072
17522998
17530715
17540773
17557799
17560118
17570736
17574548
17579118
17591977
17596875
17597658
17598964
17601559
17605296
17620406
17625450
17626784
17638910
17641021
17644809
17700165
17766609
17768377
2982829
3162913
8424942
8424943
8471846
8679613
9150447
9783545
9895299
10852815
11886525
16751781
16865088
16909112
16943282
16978288
17050629
17053163
17126294
17159989
17202367
17204263
17215516
17222412
17237391
17273784
17293478
17318077
17324777
17353357
17360662
17389738
17391668
17391979
17418116
17474154
17478422
17478551
17481928
17485468
17516543
17530708
17543885
17549683
17560204
17560553
17576802
17579023
17579048
17612560
17620361
17634193
17762268
12223100
15214860
16458528
16837651
17068209
17133352
17158884
17203207
17213961
17335076
17352758
17374997
17379848
17392319
17396111
17485851
17530031
17541159
2070682
12441094
12591230
14502602
15456771
15747730
16004987
16390551
1733936
17388018
3153459
15866162
16197550
17003102

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio
Human

Mouse chromosome position 7 13.98 cM
7 6.5 cM

OMIM ID 190180
219700
131300
618213
OMIM:190180
OMIM:131300

Rat chromosome position 1q21
1q22

Hugo ID 11766
HGNC:11766

Human chromosome position 19q13.2
19q13.1

Swiss-Prot Accession P01137
P01137.2
P04202
Q3UNK5
P04202.1
P17246
P17246.1
A8K792
Q9UCG4
Q53YM8
Q49IK8
Q49IL8
Q5PY19
Q671U8
Q671V1
Q7Z487
Q7Z488
Q86YU2
Q9R231
TGFB1_HUMAN
TGFB1_MOUSE
TGFB1_RAT
Q3UNK5_MOUSE

PIR ID A27513
A01396
S10219

GenBank ID NC_000019
NM_000660
NP_000651
XM_011527242
XP_011525544
NG_013364
AC011462
AH013154
AAQ18641
AY059373
AAL27646
AY576687
AAT77143
AY576688
AAT77144
AY871232
AAX59016
AY871233
AAX59017
AY871234
AAX59018
AY871235
AAX59019
AY871236
AAX59020
AY871237
AAX59021
AY871238
AAX59022
AY871239
AAX59023
AY871240
AAX59024
AY871241
AAX59025
AY871242
AAX59026
AY871243
AAX59027
AY871244
AAX59028
AY871245
AAX59029
CH471126
EAW57032
EAW57033
CQ759646
CAF32686
CS674262
CAP12291
CS805735
CAP40172
EU338452
ACA64647
EU338453
ACA64648
EU338454
ACA64649
HC919732
CBN73463
HC919943
CBN73468
J04431
AAN86616
JA104601
CCA63970
LM651041
CDW91956
LM651042
CDW91957
LM651043
CDW91958
LM651044
CDW91959
LM651045
CDW91960
LM651046
CDW91961
LM651047
CDW91962
LM651048
CDW91963
LM651049
CDW91964
LM651050
CDW91965
LM651051
CDW91966
LM651052
CDW91967
LM651053
CDW91968
LM651054
CDW91969
LM651055
CDW91970
LM651056
CDW91971
LM651057
CDW91972
LM651058
CDW91973
LM651059
CDW91974
X05839
CAA29283
AI304490
AK291907
BAF84596
AK307742
AY820829
AAV71148
BC000125
AAH00125
BC001180
AAH01180
BC022242
AAH22242
BG115704
BM692012
BP267938
BT007245
AAP35909
DA935180
M38449
AAA36735
X02812
CAA26580
P01137
NC_000073
NM_011577
NP_035707
AC162614
AH003562
AAB00138
AY340221
AAR06153
AY342403
AAQ75558
CH466593
EDL24239
M57902
AAO87818
AA510019
AA821506
AJ009862
CAA08900
AK144163
BAE25742
BC013738
AAH13738
BQ030974
CK625059
M13177
AAA40423
P04202
NC_005100
NM_021578
NP_067589
AC_000069
AABR07002708
AAHX01004316
AF105069
AAD20222
CH473979
EDM07998
AY550025
AAS55640
BC076380
AAH76380
X52498
CAA36741
P17246
NC_018930
AMYH02036132
AMYH02036133
AY330201
AY330202
AAQ18642
EU832132
ACE87482
EU832225
ACE86795
AC_000029
AAHY01060005
L42456
L42457
L42458
L42459
L42460
L42461
L42462
AC_000151
ABBA01040804
ABBA01040805
XM_005259187
XP_005259244
AABR06003977
NT_011109
NW_927217
NW_001838496
NG_013091
AC_000062
CR592182
CR601792
CR612251
Q49IK8
Q49IL8
Q5PY19
Q671U8
Q671V1
Q7Z487
Q7Z488
Q86YU2
NT_039413
NW_001030836
Q3UNK5
NW_047556
NW_001084763
Q9R231
NT_039438
Q53YM8
NW_000303
135677
4416082
45239050
49904628
57342
81869719
81872961
1161141
123794832
135675
15489275
201953
34559867
3688424
37964129
74184431
1212989
121945936
121949076
12652749
12654683
135674
18490116
30583329
33431109
33431110
339558
37093
44849597
45602840
50428875
50428877
56112358
62003110
62003112
62003114
62003116
62003118
62003120
62003122
62003124
62003126
62003128
62003130
62003132
62003134
62003136
74723325
74723569
74724333
74724443
74724444
74750078
119577436
119577437
148692292
149056567
NT_086903
135671
145309044
163748
AAA30778
ABP57733
EF523342
M36271
NC_007316
NW_001493615
P18341
XM_592497
XP_592497
AI396571
30313704
82097752
AAO60240
AY178450
DU644789
NC_007126
NM_182873
NP_878293
NW_001511175
Q7ZZU7
XM_357724
XP_357724
NT_039407
NW_043361
33504524
126006436
33504525
ZDB-GENE-030131-9981
359834
Dr.76626
ZDB-GENE-030618-1
dre:359834

Swiss-Prot ID TGFB1_HUMAN
TGFB1_MOUSE
TGFB1_RAT
Q3UNK5_MOUSE

Cell Localization Secreted
Extracellular space
Extracellular matrix
Extracellular
Secreted, extracellular space, extracellular matrix

Ensembl ID ENSG00000105329
ENSP00000221930.4
ENST00000221930.5
ENSMUSG00000002603
ENSMUSP00000002678.9
ENSMUST00000002678.9
ENSRNOG00000020652
ENSRNOP00000028051.2
ENSRNOT00000028051.4
ENSP00000221930
ENST00000221930
ENSMUSP00000002678
ENSMUST00000002678
ENSRNOP00000028051
ENSRNOT00000028051

MGI ID MGI:98725
98725

RGD ID 69051

Unigene ID Hs.645227
Rn.40136
Mm.248380
Hs.155218
Hs.1103
Bt.469
Dr.76626
Mm.9154

Homologene ID 540

Shape Rhomb

IPI ID IPI00000075
IPI00114457
IPI00214538

Microarray ID 101918_at
1370082_at
X52498cds_at
A_42_P522899
279179_Rn
1420653_at
Msa.1226.0_at
Msa.1226.0_g_at
1416786_at
A_65_P10703
M13177.1
X05839
41445_at
1634_s_at
1830_s_at
203084_at
203085_s_at
M38449_s_at
X05839_rna1_s_at
1495_AT
A_23_P412335
NM_000660.1
A_51_P390715
A_14_P129694
A_14_P133632
A_14_P131774
A_24_P79054

Homo sapiens Chromosome position 19q13.2

Ensembl Transcript ID ENST00000221930

ENSEMBL ENSG00000105329

FunctionalClass protein N-terminus binding
protein binding
transcriptional activator
transforming growth factor beta receptor binding
growth factor
transcription activator
DNA binding
N-methyltransferase

Bos taurus Chromosome position 18

Mus musculus Chromosome position 7 6.5 cM

KEGG pathway Cell cycle
MAPK signaling pathway
TGF-beta signaling pathway
Chronic myeloid leukemia
Colorectal cancer
Pancreatic cancer
Renal cell carcinoma

Ensembl Gene ID ENSG00000105329

Keyword transforming growth factor
growth factor
matrix
antisense RNA
desmoplakin
map kinase
cytokine activity
signal transducer
RNA
cytoplasm
cytokeratin
nucleus
thrombin
growth hormone receptor ligand
DNA

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: lymphoid tissue; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: breast; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in granular layer; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: Purkinje cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: colon; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: duodenum; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: epididymis; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: fallopian tube; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: gall bladder; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: heart muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: neuronal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in glomeruli; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in tubules; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: hepatocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: macrophages; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: pneumocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: germinal center cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: non-germinal center cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: follicle cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: ovarian stroma cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: islets of Langerhans; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: parathyroid gland; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: decidual cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: trophoblastic cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: prostate; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: rectum; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: salivary gland; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: seminal vesicle; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: skeletal muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: small intestine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in white pulp; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: stomach, lower; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: Leydig cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: thyroid gland; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: germinal center cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: non-germinal center cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: urinary bladder; Cell type: urothelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: vagina; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus
pre-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Supportive
post-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive

LocatorString pmquery:curcumin+prostate+cancer
pmquery:curcumin prostate cancer
pmquery:egfr+transactivation

Danio rerio Chromosome position LG 15