Protein IL27

URN urn:agi-llid:246778
Total Entities 0
Connectivity 1939
Name IL27
Description interleukin 27
Notes The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand

Pathway Th1-Cell Differentiation
AHR Signaling in Tr1 Cells Function
Eosinophil Survival by Cytokine Signaling
Dendritic Cells Function in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Atopic Dermatitis
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Genes with Susceptibility for Crohn's Disease and Ulcerative Colitis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Glomerulonephritis
IL27R -> STAT Signaling
C5AR1 -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Spleen
Elevated Receptors -> Expression Targets in Thymus
TLR4 -> NF-kB/IRF Expression Targets
PPAR Psoriasis
1_Differentiation of psoriatic T cells
4_1_Polymorphisms associated with inflammatory bowel diseases
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Inflammatory Bowel Diseases

MedScan ID 246778

LocusLink ID 246778
246779
365368

Alias interleukin 27
IL-27 p28 subunit
interleukin-12p35-related protein p28
interleukin-27 receptor ligand activity
interleukin IL30
RGD1561420
IL30
IL-27 subunit alpha
interleukin-27 subunit alpha
interleukin-27 receptor ligand
IL27
interleukin IL27p28
IL-12p35-related protein p28
interleukin IL27
interleukin IL-27 subunit
interleukin-27 receptor ligands
IL27p28
IL-27A
interleukin IL-27 p28 subunit
interleukin 27A
IL-27 subunit
MGC71873
interleukin 30
interleukin IL-27A
OTTHUMP00000122516
p28
IL-27
IL27A
IL-27-A
IL27-A
interleukin-30
IL-27p28

GO ID 0005125
0045523
0005102
0006954
0045087
0070106
0002230
0045078
0042129
0045625
0009617
0005829
0005788
0005576
0005615
0002376
0010469
0050688

KEGG ID hsa:246778
mmu:246779
rno:365368

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 7

OMIM ID 608273

Rat chromosome position 1q36

Hugo ID 19157
HGNC:19157

Human chromosome position 16p12.1-p11.2
16p11

Swiss-Prot Accession Q8NEV9
Q8NEV9.2
Q8K3I6
Q8K3I6.1
A0N0L2
Q6P676
D3ZPW3

GenBank ID NC_000016
XM_011545780
XP_011544082
NM_145659
NP_663634
AC138894
CH471279
EAW52277
EF064720
ABK41903
JA104595
CCA63967
AY099296
AAM34498
BC062422
AAH62422
Q8NEV9
NC_000073
XM_006507857
XP_006507920
NM_145636
NP_663611
AC125169
CH466531
EDL17402
AI662173
AK152114
BAE30958
AK153466
BAE32017
AY099297
AAM34499
BC119402
AAI19403
Q8K3I6
NC_005100
XM_344962
XP_344963
AC_000069
XM_002725687
XP_002725733
AABR07005777
AAHX01008502
NC_018927
AMYH02031790
HQ447563
ADQ32049
AC_000029
AAHY01066400
AC_000148
ABBA01043652
AABR06008864
NT_010393
NW_001838230
NW_926262
AC_000059
NT_039433
NW_001030877
NW_001084773
NW_047562
AABR03000083

Swiss-Prot ID IL27A_HUMAN
IL27A_MOUSE
D3ZPW3_RAT

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000197272
ENSP00000349365.1
ENST00000356897.1
ENSMUSG00000044701
ENSMUSP00000054637.5
ENSMUST00000058429.5
ENSP00000349365
ENST00000356897
ENSMUSP00000054637
ENSMUST00000058429

MGI ID MGI:2384409
2384409

RGD ID 1561420

Unigene ID Hs.528111
Mm.222632

Homologene ID 17087

Shape Rhomb

IPI ID IPI00302598
IPI00170089
IPI00766159
IPI00361203