Protein RHEB

URN urn:agi-llid:6009
Total Entities 0
Connectivity 911
Name RHEB
Description Ras homolog enriched in brain
Notes This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
ObjectType Protein

Pathway Oncogene Induced Cellular Senescence
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Hypoxia Inhibits mTOR Signaling
SIRT1 Signaling in Aging
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Insulin Influence on Protein Synthesis
Insulin Signaling
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Glucocorticoids in Insulin Resistance in Skeletal Muscles
Peutz-Jeghers Syndrome
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Angiogenesis in Endometriosis
Polycystins Mutation Effects in Cystic Kidney Disease
AREG -> HIF1A Expression Targets
EGF -> HIF1A Expression Targets
EGFR/ERBB2 -> HIF1A Signaling
EREG -> HIF1A Expression Target
HBEGF -> HIF1A Expression Targets
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
HIF1A as Master Regulator of Angiogenesis in Cancer
MTOR/TORC in Cancer Cell Motility and Invasion
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
NRG1 -> HIF1A Expression Target
Androgen Receptor non-Genomic Signaling
TGF-beta Signaling
AMPK Signaling
mTOR Signaling
VEGF Signaling
EGFR Signaling
TGFA -> HIF1A Expression Targets
ace2
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Formation of cysts in polycystic kidney disease
3_Enhanced angiogenesis in endometriosis
2_Neuron and Schwann cell death

MedScan ID 6009

LocusLink ID 6009
19744
26954

Alias GTP-binding protein Rheb
GTPase Rheb
Ras homolog enriched in brain 2
RAS-homolog enriched in brain
Rheb guanosine triphosphatase
OTTMUSP00000027651
Rhebs
Ras homolog enriched in brain II
Rheb1
RHEB
RHEB2
Rheb GTP binding protein
Rheb GTPases
Rheb GTPase
Ras homologue enriched in brain protein
MGC111559
Ras homolog, mTORC1 binding
Ras homolog enriched in brain

GO ID 0019003
0005525
0003924
0000287
0019901
0007050
0120163
0032008
0048714
0016241
2000074
0007165
0007264
0000139
0005829
0005789
0070062
0005765
0016020
0005886
0014069
0005681
0046872
0000166
0032006
0099175
0005794
0005737
0030425
0005783
0098978
0043025
0048168
0016236
0015031
0008286
0005622

KEGG ID hsa:6009
mmu:19744
rno:26954

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 5

OMIM ID 601293

Rat chromosome position 4q11
4

Hugo ID 10011
HGNC:10011

Human chromosome position 7q36.1
7q36

Swiss-Prot Accession A0A090N900
Q15382
Q15382.1
Q540E6
Q921J2
Q921J2.1
Q62639
Q62639.1
B3KWN6
D3DX13
Q53Y56
Q99444

PIR ID S68419
I55401

GenBank ID NC_000007
NM_005614
NP_005605
XM_011516457
XP_011514759
XM_024446854
XP_024302622
AACC02000108
EAL24515
AC005996
AAD15548
CH471173
EAW53986
EAW53987
EAW53988
EAW53989
JC006890
CDL93493
KT584052
AF148645
AAF73125
AF493921
AAM12635
AK125446
BAG54198
AK289370
BAF82059
BC016155
AAH16155
BC066307
AAH66307
BC107705
AAI07706
BG702213
BM670621
BT006958
AAP35604
D78132
BAA11211
DA475169
Z29677
CAA82774
Q15382
NC_000071
NM_053075
NP_444305
AC125270
AC137938
CH466586
EDL03089
EDL03090
JC006888
CDL93492
AB039919
BAB13483
AK151213
BAE30208
AK158213
AY197373
AAO43226
BC012273
AAH12273
Q921J2
NC_005103
NM_013216
NP_037348
AC_000072
AABR07059178
AABR07059179
AABR07059180
AABR07059181
AAHX01027281
AAHX01027282
CH474057
EDL86374
EDL86375
EDL86376
EDL86377
BC088857
AAH88857
FQ212847
FQ214530
FQ218725
FQ219039
FQ225701
FQ230203
U08227
AAA21380
Q62639
NC_018918
AMYH02017074
AC_000027
AAHY01042997
AAHY01042998
AAHY01042999
XM_006716081
XP_006716144
AC_000139
ABBA01035154
BC009638
XM_006535647
XP_006535710

Swiss-Prot ID RHEB_HUMAN
RHEB_MOUSE
RHEB_RAT

Cell Localization Endomembrane system
Golgi apparatus membrane
Cytoplasm
Cytosol
Endoplasmic reticulum membrane
Cytoplasm, cytosol

Ensembl ID ENSG00000106615
ENSP00000262187.5
ENST00000262187.10
ENSMUSG00000028945
ENSMUSP00000030787.8
ENSMUST00000030787.8
ENSRNOG00000050578
ENSRNOP00000063915.2
ENSRNOT00000071737.2
ENSP00000262187
ENST00000262187
ENSMUSP00000030787
ENSMUST00000030787
ENSRNOP00000063915
ENSRNOT00000071737

MGI ID MGI:97912

RGD ID 621840

Unigene ID Hs.283521
Hs.568850
Hs.647068
Mm.319175
Rn.859

Homologene ID 123916