URN | urn:agi-llid:64581 |
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Total Entities | 0 |
Connectivity | 1145 |
Name | CLEC7A |
Description | C-type lectin domain family 7 member A |
Notes | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Plasma membrane |
Class | Receptor |
Pathway | Mannose Receptor Signaling |
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Dectin-1 (CLEC7A) Signaling | |
Antigen-Presenting Cell Role in Asthma | |
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood | |
pprarg neg, uknown targets, ps-positive | |
Model of PPARG signaling in psoriasis | |
1_Th2 cell response in asthma | |
4_2_Genes with mutations currently associated with ulcerative colitis | |
4_1_Polymorphisms associated with inflammatory bowel diseases |
MedScan ID | 64581 |
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LocusLink ID | 64581 |
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56644 | |
502902 |
Alias | dendritic cell-associated C-type lectin 1 |
---|---|
Dendritic cell-associated C-type lectin-1 beta | |
beta-glucan receptors | |
C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 | |
UNQ539/PRO1082 | |
SCARE2 | |
Clec7b | |
DECTIN-1 receptor | |
transmembrane protein dectin I | |
lectin-like receptor 1 | |
DC-associated C-type lectin 1 | |
CD369 | |
RGD1565140 | |
c-type lectin domain family 7, member a | |
DECTIN I | |
lectin-like receptor I | |
DECTIN-1 receptors | |
Clecsf12 | |
clec7a | |
hDectin I | |
DECTIN1 | |
beta-glucan receptor | |
hDectin-1 | |
C-type lectin, superfamily member 12 | |
transmembrane protein dectin-1 | |
C-type lectin, superfamily member XII | |
CANDF4 | |
Beta-glucan receptor isoform B | |
C-type lectin domain containing 7A | |
Lectin-like receptor 1B | |
beta-gr | |
BGR | |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | |
C-type lectin superfamily member 12 | |
dectin-1 | |
dendritic cell-associated C-type lectin-1 | |
C-type lectin domain family 7 member A |
GO ID | 0001872 |
---|---|
0042287 | |
0030246 | |
0046872 | |
0008329 | |
0042110 | |
0009756 | |
0008037 | |
0071226 | |
0042832 | |
0016046 | |
0032491 | |
0006954 | |
0045087 | |
0002221 | |
0006910 | |
1903431 | |
0030335 | |
0008284 | |
0043280 | |
1900017 | |
0010628 | |
0045078 | |
0032731 | |
0045082 | |
0045084 | |
0045086 | |
0045410 | |
0045416 | |
0051712 | |
0051251 | |
0071639 | |
0045429 | |
0050766 | |
0031334 | |
0060267 | |
0032930 | |
0042535 | |
0090303 | |
0009986 | |
0005737 | |
0016021 | |
0043231 | |
0005654 | |
0005886 | |
0002366 | |
0002223 | |
0001874 | |
0001846 | |
0030247 | |
0002752 | |
0001879 | |
0002376 | |
0006911 | |
0032760 | |
0002238 | |
0001878 | |
0016337 | |
0009897 | |
0016020 |
KEGG ID | hsa:64581 |
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Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
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Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 6 |
---|
OMIM ID | 606264 |
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614079 | |
613108 |
Rat chromosome position | 4q42 |
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Hugo ID | 14558 |
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HGNC:14558 |
Human chromosome position | 12p13.2 |
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Swiss-Prot Accession | Q68D78 |
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Q9BXN2 | |
A0A024RAN9 | |
A0A0S2Z5Q1 | |
Q9BXN2.1 | |
V9GXI5 | |
Q6QLQ4.3 | |
B2RYG9 | |
B5BUZ1 | |
B5BUZ2 | |
B2R861 | |
B7Z494 | |
B7Z5A9 | |
B7Z5B9 | |
Q6IPS7 | |
Q96D32 | |
Q96DR9 | |
Q96LD3 | |
Q96PA4 | |
Q96PA5 | |
Q96PA6 | |
Q96PA7 | |
Q96PA8 | |
Q9H1K3 | |
Q6QLQ4 |
Swiss-Prot ID | CLC7A_HUMAN |
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Cell Localization | Cell membrane |
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Cytoplasm |
Ensembl ID | ENSG00000172243 |
---|---|
ENSP00000266456.6 | |
ENST00000353231.9 | |
ENSP00000302569.8 | |
ENST00000304084.12 | |
ENSP00000431461.1 | |
ENST00000533022.5 | |
ENSP00000298523.5 | |
ENST00000298523.9 | |
ENSP00000379743.2 | |
ENST00000396484.6 | |
ENSP00000312089.4 | |
ENST00000310002.4 | |
ENSP00000434392.1 | |
ENST00000531192.5 | |
ENSMUSG00000079293 | |
ENSMUSP00000139167.1 | |
ENSMUST00000184581.2 | |
ENSMUST00000195589.5 | |
ENSRNOG00000054251 | |
ENSRNOP00000073639.1 | |
ENSRNOT00000091552.1 | |
ENSRNOP00000069723.1 | |
ENSRNOT00000077793.1 | |
ENSP00000266456 | |
ENST00000353231 | |
ENSP00000302569 | |
ENST00000304084 | |
ENSP00000431461 | |
ENST00000533022 | |
ENSP00000298523 | |
ENST00000298523 | |
ENSP00000379743 | |
ENST00000396484 | |
ENSP00000312089 | |
ENST00000310002 | |
ENSP00000432876 | |
ENST00000529761 | |
ENSP00000434392 | |
ENST00000531192 | |
ENSMUSP00000141234 | |
ENSMUST00000195589 | |
ENSRNOP00000073639 | |
ENSRNOT00000091552 | |
ENSRNOP00000069723 | |
ENSRNOT00000077793 | |
ENSRNOG00000033879 | |
ENSRNOP00000056630 | |
ENSRNOT00000059885 |
MGI ID | MGI:1861431 |
---|
RGD ID | 1565140 |
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Unigene ID | Hs.143929 |
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Mm.239516 | |
Rn.15743 |
Homologene ID | 49606 |
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Shape | Stick-vertex |
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