Protein TSC2

URN urn:agi-llid:7249
Total Entities 0
Connectivity 2180
Name TSC2
Description tuberous sclerosis 2
Notes Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
ObjectType Protein

Pathway Oncogene Induced Cellular Senescence
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Hypoxia Inhibits mTOR Signaling
SIRT1 Signaling in Aging
Insulin Influence on Protein Synthesis
Insulin Signaling
Preconditioning Ischemia
Proteins Involved in Diabetes Mellitus Type 2
Glucocorticoids in Insulin Resistance in Skeletal Muscles
Proteins Involved in non-Alcoholic Fatty Liver Disease
Peutz-Jeghers Syndrome
Proteins Involved in Peutz-Jeghers Syndrome
Proteins Involved in Pancreatic Cancer
Proteins Involved in Epilepsy
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Angiogenesis in Endometriosis
Androgen Receptor/SGK1 Signaling
Polycystins Mutation Effects in Cystic Kidney Disease
Proteins Involved in Polycystic Kidney Disease
AREG -> HIF1A Expression Targets
EGF -> HIF1A Expression Targets
EGFR/ERBB2 -> HIF1A Signaling
EREG -> HIF1A Expression Target
HBEGF -> HIF1A Expression Targets
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
HIF1A as Master Regulator of Angiogenesis in Cancer
MTOR/TORC in Cancer Cell Motility and Invasion
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
Genes with Mutations in Cancer Metabolic Reprogramming
Proteins with Altered Expression in Cancer Metabolic Reprogramming
NRG1 -> HIF1A Expression Target
Androgen Receptor non-Genomic Signaling
TGF-beta Signaling
AMPK Signaling
mTOR Signaling
VEGF Signaling
EGFR Signaling
TGFA -> HIF1A Expression Targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
1_Formation of cysts in polycystic kidney disease
3_Enhanced angiogenesis in endometriosis
2_Neuron and Schwann cell death
Model of PPARG signaling in psoriais (tested)

Group Genes with Mutations Associated with Pancreatic Cancer
Proteins Involved in Cowden Syndrome
Genes Associated with Syndromic Epilepsy
Genes Associated with Mental Retardation and Brain Malformations in Epilepsy

MedScan ID 7249

LocusLink ID 7249
22084
24855

Alias tuberin isoform III
Tuberins
tuberin isoform II
tuberous sclerosis complex 2 protein
tuberous sclerosis-II
PPP1R160
FLJ43106
OTTHUMP00000198394
tuberous sclerosis 2
Tuberous sclerosis 2, (renal carcinoma)
tumor suppressor protein tuberous sclerosis complex 2
TSC complex subunit 2
tuberin isoform I
tuberin isoform 2
TCS2
TSC4
tuberin isoform 3
LOC124054
Tuberin
tuberous sclerosis-2
tuberin isoform 1
protein phosphatase 1, regulatory subunit 160
tuberous sclerosis 2 homolog protein
tuberous sclerosis II
TSC2
LAM
tuberous sclerosis 2 protein
Nafld
tuberous sclerosis 2 protein homolog
Rc
renal carcinoma

GO ID 0005096
0051879
0019902
0042803
0031267
0043276
0006897
0007507
0048009
0032007
0030178
0008285
0046627
1901525
0014067
0051898
0006469
0001843
0050918
0043547
0016239
0006606
0043491
0008104
0051726
0030100
0046626
0051056
0016192
0016032
0005794
0033596
0005737
0005829
0005764
0016020
0005634
0048471
0014069
0071889
0047485
0046982
0007568
0030030
0032869
0030010
0045184
0046323
0043407
1904262
0050771
0045792
0050680
0010719
0048147
0016242
0048550
0001933
1905563
0014065
0010508
0045785
0060999
0010763
0010976
0045944
0051291
0051260
0034394
0044861
0099175
0001666
0007165
0035176
0005901
0042995
0005856
0030425
0098978
0030426
0043231
0045121
0043005
0043025
0032991
0045202
0007050
0071500
0043234
0038095
0006953
0007173
0008543
0045087
0008286
0048011
0048015
0032320
0005623
0005622
0005097
0032851

KEGG ID hsa:7249
rno:24855
mmu:22084

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 17 12.41 cM

OMIM ID 191092
607341
606690
613254

Rat chromosome position 10q12

Hugo ID 12363
HGNC:12363

Human chromosome position 16p13.3

Swiss-Prot Accession P49815
X5D7Q2
B3KWH7
Q5HYF7
H3BMQ0
P49815.2
Q3UGI8
Q7TT21
Q3UHB2
Q3UG88
Q3TQ10
Q61037.1
P49816
A0A0G2JSL4
P49816.1
A7E2E2
B4DIL8
B4DIQ7
B4DRN2
B7Z2B8
C9J378
O75275
Q4LE71
Q8TAZ1
X5D2U8
Q61037

PIR ID A49420
S57329

GenBank ID NC_000016
XM_011522638
XP_011520940
XM_017023617
XP_016879106
NM_001114382
NP_001107854
NM_001363528
NP_001350457
NM_001077183
NP_001070651
NM_001318827
NP_001305756
NM_001318831
NP_001305760
NM_001318829
NP_001305758
NM_000548
NP_000539
NM_001370405
NP_001357334
NM_001370404
NP_001357333
NM_021055
NP_066399
XM_017023618
XP_016879107
XM_011522636
XP_011520938
XM_011522637
XP_011520939
XM_017023615
XP_016879104
XM_011522639
XP_011520941
XM_011522640
XP_011520942
XM_024450413
XP_024306181
NM_001318832
NP_001305761
NG_005895
AB014460
BAA32694
AC005600
AAC34210
AC093513
AH004937
AAB41564
CH471112
EAW85556
EAW85557
EAW85558
EAW85559
EAW85560
KY922729
AWN00470
MG589762
AYE20492
AB210000
BAE06082
AK022401
AK094152
BAG52831
AK125096
BAG54139
AK294548
BAH11804
AK295672
BAG58530
AK295728
BAG58569
AK299343
BAG61344
BC025364
AAH25364
BC046929
AAH46929
BC150300
AAI50301
BF194994
BM966762
BX647816
CAI46010
CA427637
DA316794
DB288276
DC402106
KJ534954
AHW56594
KJ534955
AHW56595
KJ534956
AHW56596
KJ534957
AHW56597
KJ534958
AHW56598
KJ534982
AHW56622
KJ534983
AHW56623
KJ534984
AHW56624
KJ534985
AHW56625
KJ535011
AHW56650
KJ535022
AHW56661
KJ535038
AHW56677
KJ535039
AHW56678
KJ535051
AHW56690
KJ535091
AHW56730
KJ535094
AHW56733
LC224282
BAX02962
LC224283
BAX02963
LC224284
BAX02964
LC224285
BAX02965
LC224286
BAX02966
LC224287
BAX02967
LC224288
BAX02968
LC224289
BAX02969
LC224290
BAX02970
LC224291
BAX02971
LC224292
BAX02972
LC224293
BAX02973
LC224294
BAX02974
S82474
AAB37376
X75621
CAA53287
P49815
NC_000083
NM_001286716
NP_001273645
NM_001286714
NP_001273643
NM_001286718
NP_001273647
NM_001039363
NP_001034452
NM_011647
NP_035777
NM_001286720
NP_001273649
NM_001286713
NP_001273642
XM_017317392
XP_017172881
XM_017317389
XP_017172878
XM_017317388
XP_017172877
XM_017317387
XP_017172876
XM_017317385
XP_017172874
XM_006524044
XP_006524107
XM_006524040
XP_006524103
XM_017317386
XP_017172875
XM_017317384
XP_017172873
XM_017317390
XP_017172879
XM_017317393
XP_017172882
XM_017317391
XP_017172880
XR_001782062
XR_001782063
AB009371
BAA28845
AC132367
AF333927
AAK48834
CH466606
EDL22341
EDL22342
EDL22343
EDL22344
EDL22345
U38921
AF132986
AAD27867
AK143799
AK147016
BAE27610
AK147302
AK147487
BAE27945
AK147874
AK147908
BAE28220
AK148062
BAE28321
AK148072
BAE28325
AK148271
AK163991
BAE37575
AK164586
BAE37839
AK170589
BAE41898
AK171007
BAE42178
AK177552
AK178821
AK179783
AK179817
AK181602
AK182281
AK182662
AK182995
AK183282
AK183464
AK183501
AK183941
AK184422
AK184645
AK184680
AK184991
AK185522
AK186134
AK187103
AK187131
AK187383
AK188248
AK190188
AK190229
AK191260
AK191520
AK191587
AK193509
AK196271
AK197601
AK198541
AK198980
AK199927
AK200853
AK201826
AK202101
AK202630
AK203056
AK203435
AK204110
AK204112
AK205325
AK205469
AK205980
AK206076
AK208040
AK209880
AK210945
AK211775
AK214850
AK215427
AK215802
AK215985
AK216627
AK217069
AK217739
AK217801
AK218459
AK218943
AK218975
AK219279
AK220072
BC052207
BC052449
AAH52449
BC060701
AAH60701
BY742714
U37775
AAA86901
AAA86902
U39818
AAB18754
Q61037
NC_005109
NM_012680
NP_036812
XM_006245909
XP_006245971
XM_017597022
XP_017452511
XM_017597020
XP_017452509
XM_017597019
XP_017452508
XM_017597027
XP_017452516
XM_017597026
XP_017452515
XM_017597024
XP_017452513
XM_017597025
XP_017452514
XM_017597023
XP_017452512
XM_017597021
XP_017452510
XM_008767544
XP_008765766
AC_000078
AAHX01062902
AAHX01062903
AC093937
CH473948
EDM03846
EDM03847
EDM03848
D84251
BAA25108
D85767
D50413
BAA08914
U24150
AAC52289
P49816
XM_011522641
XP_011520943
XM_005255529
XP_005255586
XM_005255531
XP_005255588
NC_018927
AMYH02031242
L48517
L48518
L48519
L48520
L48522
L48523
L48524
L48525
L48526
L48528
L48529
L48531
L48535
L48536
L48537
L48538
L48539
L48540
L48541
L48542
L48543
L48544
L48546
XM_011246370
XP_011244672
XM_011246369
XP_011244671
XM_011246365
XP_011244667
XM_011246368
XP_011244670
XR_876467
XM_011246373
XP_011244675
XM_011246367
XP_011244669
XM_011246364
XP_011244666
XM_011246371
XP_011244673
XM_011246375
XP_011244677
XM_011246372
XP_011244674
AC_000039
AAHY01131651
AAHY01131652
XM_006245917
XP_006245979
XM_006245912
XP_006245974
XM_008767543
XP_008765765
XM_006245916
XP_006245978
XM_006245914
XP_006245976
XM_006245915
XP_006245977
XM_006245913
XP_006245975
XM_006245910
XP_006245972
XM_006245911
XP_006245973
XM_005255527
XP_005255584
XM_005255528
XP_005255585
XM_005255530
XP_005255587
XM_005255532
XP_005255589
AC_000148
ABBA01030275
ABBA01030276
ABBA01030277
ABBA01030278
ABBA01030279
XM_006524041
XP_006524104
XM_006524038
XP_006524101
XM_006524045
XP_006524108
XM_006524039
XP_006524102
XM_006524037
XP_006524100
XM_006524042
XP_006524105
XM_006524046
XP_006524109
XM_006524043
XP_006524106
XM_005255533
XP_005255590
XR_243299
XM_005255534
XP_005255591
AABR06063007

Swiss-Prot ID TSC2_HUMAN
TSC2_RAT

Cell Localization Cytoplasm
Membrane
Nucleus

Ensembl ID ENSG00000103197
ENSP00000219476.3
ENST00000219476.9
ENSP00000384468.2
ENST00000401874.7
ENSP00000344383.4
ENST00000350773.9
ENSP00000399232.2
ENST00000439673.6
ENSP00000371978.6
ENST00000382538.10
ENSP00000454487.1
ENST00000568454.6
ENSP00000495459.1
ENST00000642365.1
ENSP00000496611.1
ENST00000644329.1
ENSMUSG00000002496
ENSMUSP00000094986.1
ENSMUST00000097373.1
ENSMUSP00000154338.1
ENSMUST00000227745.1
ENSMUSP00000153792.1
ENSMUST00000226398.1
ENSMUSP00000154706.1
ENSMUST00000228412.1
ENSMUSP00000153869.1
ENSMUST00000226284.1
ENSMUSP00000153758.1
ENSMUST00000227607.1
ENSRNOG00000011375
ENSRNOP00000016221.1
ENSRNOT00000016221.3
ENSRNOP00000039381.5
ENSRNOT00000052138.6
ENSP00000219476
ENST00000219476
ENSP00000384468
ENST00000401874
ENSP00000344383
ENST00000350773
ENSP00000399232
ENST00000439673
ENSP00000371978
ENST00000382538
ENSMUSP00000094986
ENSMUST00000097373
ENSRNOP00000016221
ENSRNOT00000016221

MGI ID MGI:102548
102548

RGD ID 3908

Unigene ID Hs.90303
Mm.30435
Rn.5875

Homologene ID 462