Protein IL33

URN urn:agi-llid:90865
Total Entities 0
Connectivity 3788
Name IL33
Description interleukin 33
Notes The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway NOD-like Receptors
Toll-like Receptor Independent Sterile Inflammation
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Proteins Involved in Myocarditis
Mast-Cells Activation in Atopic Dermatitis
Acute Phase in Atopic Dermatitis
Proteins with Altered Expression in Atopic Dermatitis
Atopic Dermatitis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Macrophage Dysfunction
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Eosinophil Survival in Asthma
IL33 Signaling Related Eosinophilia in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Dendritic Cell Dysfunction in Psoriatic Arthritis
Proteins Involved in Rheumatoid Arthritis
PAPA Syndrome
Mevalonate Kinase Deficiency
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Mediterranean Fever
Proteins Involved in Osteoporosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Age-Related Macular Degeneration
Immune System Role in Otitis Media
Proteins with Altered Expression in Asthma
Elevated Receptors -> Expression Targets in Mouth
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lung
e
pathway 4
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
dsRNA induces innate immunity and INFs in alveolar cells
Dendritic Cell Activation in COVID19
2_Acute phase initiation in atopic dermatitis
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
4_2_Genes with mutations currently associated with ulcerative colitis
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell

Group Genes with Mutations in GWA Studies of Asthma

MedScan ID 90865

LocusLink ID 90865
77125
361749

Alias chromosome 9 open reading frame 26 (nf-hev)
nuclear factor for high endothelial venules
9230117N10Rik
IL33
9230117N10
DVS27
RGD1311155
chromosome 9 open reading frame 26
OTTHUMP00000021041
interleukin-1 family member 11
NF-HEV
IL1f11
RP11-575c20.2
OTTMUSP00000035769
DKFZp586H0523
interleukin IL1f11
NFEHEV
C9orf26
interleukin IL33
nuclear factor from high endothelial venules
interleukin 33
DVS27-related protein
interleukin-33
Il-33
NFHEV
IL-1F11

GO ID 0005125
0051607
0097191
0038172
0002282
0061518
0002826
0051025
0032689
0002686
0090197
0051024
0050729
0032736
0032753
0032754
0032755
0043032
0150078
0032436
0045944
0002830
0016579
0005694
0005576
0005615
0005654
0030133
0002281
0010628
0031410
0005634
0010469
0042092
0006351
0005515
0001819

KEGG ID hsa:90865
mmu:77125
rno:361749

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 19

OMIM ID 608678

Rat chromosome position 1q52

Hugo ID 16028
HGNC:16028

Human chromosome position 9p24.1

Swiss-Prot Accession O95760
O95760.1
Q8BVZ5
Q8BVZ5.1
Q66H70
Q66H70.1
B2R8L1
B4DJ35
B4E1Q9
D3DRI5
E7EAX4
Q2YEJ5
Q2YEJ4
Q3TQN0
Q99L46

GenBank ID NC_000009
XM_017015285
XP_016870774
NM_001314044
NP_001300973
NM_001314047
NP_001300976
NM_001199641
NP_001186570
NM_033439
NP_254274
NM_001314046
NP_001300975
NM_001199640
NP_001186569
NM_001314048
NP_001300977
NM_001314045
NP_001300974
NM_001353802
NP_001340731
NG_047209
AL353741
CH471071
EAW58748
EAW58749
EAW58750
EAW58751
AB024518
BAA75892
AI610794
AK295908
BAG58697
AK303943
BAG64871
AK313414
BAG36208
AL080211
AY905581
AAX86998
BC047085
AAH47085
BQ878541
CR407619
CAG28547
DA439244
DA713547
DA719342
DB199599
DB266668
DB477860
HQ641439
ADR77828
KX463463
AOZ26494
KX463464
AOZ26495
O95760
NC_000085
NM_133775
NP_598536
XM_011247399
XP_011245701
NM_001164724
NP_001158196
XM_006527463
XP_006527526
NM_001360725
AC111048
AC157785
CH466534
EDL41694
AK020353
AK030502
AK075849
BAC36003
AK163464
BAE37352
AY905582
AAX86999
BC003847
AAH03847
CJ191135
HQ176370
ADW82003
Q8BVZ5
NC_005100
XM_008760344
XP_008758566
NM_001014166
NP_001014188
AC_000069
AABR07006687
AAHX01000037
AAHX01000038
CH473953
EDM13106
EDM13107
BC081993
AAH81993
FQ212643
Q66H70
ABBA01065398
AABR06010499
AMYH02019091
XP_005251683
XP_005251684
AC_000041
XM_011518060
XM_011518061
XP_011516362
XP_011516363
AC_000141
XP_011516361
NC_018920
XM_005251626
AABR06010500
XM_005251627
AAHY01142995
AAHY01142996
AAHY01142994
CAI16003
XM_011518059
NT_008413
NW_001839149
NW_924062
AC_000052
NT_039687
NW_001030643
NW_047565
NW_001084774

Swiss-Prot ID IL33_HUMAN
IL33_MOUSE
IL33_RAT
B4DJ35_HUMAN
B4E1Q9_HUMAN

Cell Localization Nucleus
Chromosome
Cytoplasmic vesicle
Secretory vesicle
Secreted
Extracellular
Cytoplasmic vesicle, secretory vesicle

Ensembl ID ENSG00000137033
ENSP00000414238.2
ENST00000456383.3
ENSP00000394039.2
ENST00000417746.6
ENSP00000370842.3
ENST00000381434.7
ENSP00000478858.1
ENST00000611532.4
ENSMUSG00000024810
ENSMUSP00000025724.8
ENSMUST00000025724.8
ENSMUSP00000113829.2
ENSMUST00000120388.8
ENSRNOG00000016456
ENSRNOP00000022056.6
ENSRNOT00000022056.7
ENST00000381434
ENST00000456383
ENSMUST00000025724
ENSMUSP00000025724
ENSRNOP00000022056
ENSMUSP00000113829
ENSP00000414238
ENSRNOT00000022056
ENSP00000394039
ENST00000417746
ENSP00000370842
ENSMUST00000120388

MGI ID MGI:1924375
1924375

RGD ID 1311155

Unigene ID Mm.182359
Hs.731660
Rn.106849
Hs.348390

Homologene ID 14126

Shape Rhomb

IPI ID IPI00471802
IPI00908682
IPI00116304
IPI00027628
IPI00909430
IPI00882194