URN | urn:agi-llid:2920 |
---|---|
Total Entities | 0 |
Connectivity | 2777 |
Name | CXCL2 |
Description | chemokine (C-X-C motif) ligand 2 |
Notes | This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014] |
Primary Cell Localization | Extracellular |
Class | Ligand |
Pathway | CXC Chemokine Receptor Signaling |
---|---|
Toll-like Receptor Independent Sterile Inflammation | |
Neutrophil Chemotaxis | |
Vascular Endothelial Cell Activation by Blood Coagulation Factors | |
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction | |
Proteins Involved in Myocarditis | |
IL17 Signaling in Psoriasis | |
Neutrophil Recruitment in Sinovium in Gout | |
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis | |
Proteins Involved in Chronic Bronchitis | |
Proteins Involved in Glomerulonephritis | |
Endothelial Cell Dysfunction in Glomerulonephritis | |
Endothelial Cell Dysfunction in Pyelonephritis | |
HMGB1 Expression Targets | |
CXCL6 Expression Targets | |
CXCL2 Expression Targets | |
CXCL3 Expression Targets | |
CXCL5 Expression Targets | |
CSF2 -> NF-kB Expression Targets | |
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets | |
F2 -> STAT1/NF-kB Expression Targets | |
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets | |
TAM Receptor Signaling Activation in Cancer | |
Fibronectin Expression Targets | |
ICAM1 Expression Targets | |
IL15 Expression Targets | |
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood | |
Elevated Receptors -> Expression Targets in Lymphoid System and Blood | |
GPCRs Family -> Expression Targets in Lymphoid System and Blood | |
TNF Receptors -> Expression Targets in Lymphoid System and Blood | |
P2RX7 -> Expression Targets in Nerve Tissue | |
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets | |
AGT -> CREB Expression Targets | |
FASLG Expression Targets | |
TNF -> NF-kB Expression Targets | |
TNF -> CREB Expression Targets | |
TLR5 Expression Targets | |
TLR1 -> 2/6 Expression Targets | |
IL1B Expression Targets | |
TLR4 -> NF-kB/IRF Expression Targets | |
IL1A Expression Targets | |
ROS in Triggering Vascular Inflammation | |
pathway 3 | |
e | |
pathway 4 | |
New Pathway (2) | |
pprarg neg, uknown targets, ps-positive | |
comon ps_pos, pprarg_neg targets | |
New Pathway (4) | |
2_Interleukin-17 and interleukin-22 signaling in psoriasis | |
2_The role of endothelial cells in pyelonephritis | |
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis | |
drug-target moltransport | |
Interleukin-17 and interleukin-22 signaling in psoriasis |
MedScan ID | 2920 |
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LocusLink ID | 2920 |
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14825 | |
81503 |
Alias | secretory protein N51 |
---|---|
GRO2 oncogene | |
CXC ligand 2 | |
small inducible cytokine subfamily member II | |
MI2A_HUMAN | |
MIP2-alpha | |
C-X-C motif chemokine 2 | |
chemokine CXCL2 | |
macrophage-inhibitory protein-2 | |
CXCL2 | |
platelet-derived growth factor-inducible protein KC | |
CINC-2a | |
GROB | |
macrophage inflammatory protein-2-alpha | |
growth regulated protein beta | |
melanoma growth stimulatory activity beta | |
chemokine (C-X-C motif) ligand 2 | |
MGSA beta | |
Scyb | |
macrophage-inhibitory protein-2 alpha | |
MIP2 | |
MGSA-b | |
small inducible cytokine B2 | |
Gro-beta | |
chemokine (C-X-C motif) ligand II | |
small inducible cytokine subfamily member 2 | |
LOC133087 | |
CXCL2 chemokine | |
chemokine CXC ligand 2 | |
SCYB2 | |
GRO2 | |
CXC chemokine ligand 2 | |
growth-regulated protein beta | |
MIP2A | |
MIP-2a | |
macrophage inflammatory protein 2-alpha | |
KC | |
Fsp | |
N51 | |
gro | |
Gro1 | |
Mgsa | |
Scyb1 | |
C-X-C motif chemokine 1 | |
GRO1 oncogene | |
KC/GR)-alpha | |
KC/GRO-alpha | |
alpha-chemokine | |
growth-regulated alpha protein | |
CINC-1 | |
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | |
cytokine-induced neutrophil chemoattractant 1 |
GO ID | 0008009 |
---|---|
0007186 | |
0061844 | |
0071222 | |
0070098 | |
0006935 | |
0019221 | |
0006955 | |
0006954 | |
0030595 | |
0030593 | |
0002237 | |
0005576 | |
0005615 | |
0005125 | |
0008083 | |
0002526 | |
0006952 | |
0007204 | |
1902035 | |
0070965 | |
0043268 | |
0010765 | |
0032930 | |
0060326 | |
0010469 | |
0001975 | |
0032355 | |
0010332 | |
0051384 | |
0009408 | |
0032496 | |
0005623 | |
0045236 | |
0090023 | |
0042127 | |
0005829 | |
0002690 |
KEGG ID | hsa:2920 |
---|---|
mmu:14825 | |
rno:81503 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 5 44.78 cM |
---|
OMIM ID | 139110 |
---|
Rat chromosome position | 14p22 |
---|
Hugo ID | 4603 |
---|---|
HGNC:4603 |
Human chromosome position | 4q13.3 |
---|---|
4q21 |
Swiss-Prot Accession | A0A024RDD9 |
---|---|
P19875 | |
P19875.1 | |
A2RTH0 | |
P12850 | |
P12850.1 | |
P14095 | |
P14095.2 | |
Q6FGD6 | |
Q9UPB8 |
PIR ID | JH0281 |
---|---|
A32954 | |
JN0572 |
Swiss-Prot ID | CXCL2_HUMAN |
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GROA_MOUSE | |
GROA_RAT |
Cell Localization | Secreted |
---|
Ensembl ID | ENSG00000081041 |
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ENSP00000427279.1 | |
ENST00000508487.3 | |
ENSMUSG00000029380 | |
ENSMUSP00000031327.8 | |
ENSMUST00000031327.8 | |
ENSRNOG00000002802 | |
ENSRNOP00000003778.2 | |
ENSRNOT00000003778.3 | |
ENSP00000427279 | |
ENST00000508487 | |
ENSMUSP00000031327 | |
ENSMUST00000031327 | |
ENSRNOP00000003778 | |
ENSRNOT00000003778 |
MGI ID | MGI:108068 |
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RGD ID | 619869 |
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Unigene ID | Hs.75765 |
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Mm.21013 | |
Rn.10907 |
Homologene ID | 105490 |
---|
Shape | Rhomb |
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