Protein LPIN1

URN urn:agi-llid:23175
Total Entities 0
Connectivity 808
Name LPIN1
Description lipin 1
Notes This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]

Pathway mTOR Signaling
MTOR/TP53 Regulates Cell Metabolism
Lipogenesis Regulation in Adipocyte
Berardinelli-Seip Syndrome Progression (Hypothesis)
Proteins Involved in Diabetic Neuropathy
Proteins Involved in Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
Adipocyte Hypertrophy and Hyperplasia
Proteins Involved in Polycystic Ovary Syndrome
Lipodystrophy, Familial Partial
Lipogenesis/Lipolysis Activation in Cancer Cells and Cancer-Associated Adipocytes
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
PPAR Psoriasis
Model of PPARG signaling in psoriasis
1_Triglyceride storage in NAFLD

MedScan ID 23175

LocusLink ID 23175
14245
313977

Alias cDNA sequence AF180471
phosphatidate phosphatase LPIN1
KIAA0188
LPIN1
4631420P06
mKIAA0188
DKFZp781P1796
AF180471
fld
lipin 1
LPIN I
OTTHUMP00000179151
fatty liver dystrophy
lipin I
OTTHUMP00000179153
PAP1
Lipin1
fatty liver dystrophy protein
lipin-1

EC Number 3.1.3.4

GO ID 0008195
0003713
0031100
0032869
0016311
0009062
0007077
0006656
0006646
0120162
0045944
0019432
0006642
0005737
0005829
0005789
0005741
0005635
0031965
0005654
0005634
0001085
0042826
0016787
0042975
0031532
0044255
0045444
0006955
0006629
0000266
0000122
0031065
0045598
0006357
0031529
0005783
0016020
0005739
0005667
0006351
0006355

KEGG ID mmu:14245
hsa:23175

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 12 7.9 cM

OMIM ID 605518
268200

Rat chromosome position 6q16
6q15

Hugo ID 13345

Human chromosome position 2p25.1

Swiss-Prot Accession Q14693
Q14693.2
A0A1Y7VLN4
Q8CD95
Q91ZP3
E9QKQ5
Q91ZP3.1
Q5XIM8
Q9CQI2
Q9JLG6
A8MU38
B4DET9
B4DGS4
B4DGZ6
B5MC18
B7Z858
D6W506
E7ESE7
F5GY24
Q53T25
A0A0R4J0V3

GenBank ID NC_000002
NR_146080
NM_001261428
NP_001248357
NM_001349208
NP_001336137
NM_001349207
NP_001336136
XM_011510333
XP_011508635
XM_017003623
XP_016859112
XM_024452762
XP_024308530
NM_001261427
NP_001248356
XM_006711872
XP_006711935
XM_011510334
XP_011508636
XM_011510335
XP_011508637
XM_017003627
XP_016859116
XM_017003628
XP_016859117
XM_011510336
XP_011508638
XM_006711870
XP_006711933
XM_024452763
XP_024308531
NM_001349204
NP_001336133
NM_001349202
NP_001336131
NM_001349200
NP_001336129
NM_001349199
NP_001336128
NM_001349206
NP_001336135
NM_001349203
NP_001336132
NM_001349201
NP_001336130
NM_145693
NP_663731
XM_017003624
XP_016859113
XM_017003629
XP_016859118
NM_001349205
NP_001336134
XM_017003625
XP_016859114
XM_017003630
XP_016859119
XM_017003631
XP_016859120
NG_012843
AC012456
AAY14695
AC106875
CH471053
EAX00918
EAX00919
EAX00920
HI573914
CBX47446
AF147446
AI379040
AK127039
AK290235
BAF82924
AK293787
BAG57200
AK294742
BAG57885
AK294853
BAG57957
AK302922
BAH13844
AK310450
AL357194
BC018071
BC030537
AAH30537
BI459149
BP192775
CR749806
CAH18666
D80010
BAA11505
DB086946
DB153243
DC334711
Q14693
NC_000078
NM_172950
NP_766538
NM_015763
NP_056578
NM_001130412
NP_001123884
XM_006514975
XP_006515038
XM_006514977
XP_006515040
XM_006514988
XP_006515051
XM_006514978
XP_006515041
XM_006514976
XP_006515039
XM_006514982
XP_006515045
XM_006514987
XP_006515050
XM_006514983
XP_006515046
XM_006514984
XP_006515047
XM_011243815
XP_011242117
XM_006514986
XP_006515049
NM_001355598
AC122228
AC159631
CH466582
EDK98473
EDK98474
AA154452
AB093214
BAC41398
AF180471
AAF44296
AF412811
AAL07798
AK009789
AK014526
BAB29412
AK019539
BAB31786
AK030921
BAC27184
AK036250
AK141489
AK154837
BAE32865
AK180700
AK203902
BC042462
AAH42462
BY127780
BY209929
BY227625
CK621866
CX205142
Q91ZP3
NC_005105
XM_008764593
XP_008762815
NM_001012111
NP_001012111
AC_000074
AABR07063682
AABR07063683
AABR07063684
AAHX01042892
AAHX01042893
AAHX01042894
AAHX01042895
CH473947
EDM03131
EDM03132
BC083651
AAH83651
XM_006711869
XP_006711932
XM_011510337
XP_011508639
XM_011510338
XP_011508640
NM_001261429
NP_001248358
XM_006711871
XP_006711934
XM_006711874
XP_006711937
NC_018913
AMYH02003292
AMYH02003293
DQ894676
ABM85602
XM_006514985
XP_006515048
XM_006514980
XP_006515043
AC_000034
AAHY01097875

Swiss-Prot ID LPIN1_MOUSE
LPIN1_HUMAN

Cell Localization Mitochondrion outer membrane
Cytoplasm
Nucleus membrane
Nucleus
Endoplasmic reticulum membrane
Cytosol
Cytoplasm, cytosol

Ensembl ID ENSG00000134324
ENSP00000401522.2
ENST00000425416.6
ENSP00000397908.2
ENST00000449576.6
ENSP00000256720.2
ENST00000256720.6
ENSP00000379404.2
ENST00000396097.5
ENSP00000379405.1
ENST00000396098.5
ENSMUSG00000020593
ENSMUSP00000152276.1
ENSMUST00000222989.1
ENSMUSP00000070583.5
ENSMUST00000067124.5
ENSMUSP00000152466.1
ENSMUST00000221230.1
ENSMUSP00000106696.3
ENSMUST00000111067.9
ENSRNOG00000004377
ENSRNOP00000005863.4
ENSRNOT00000005863.6
ENSP00000401522
ENST00000425416
ENSP00000397908
ENST00000449576
ENSP00000379405
ENST00000396098
ENSP00000256720
ENST00000256720
ENSP00000379406
ENST00000396099
ENSP00000379404
ENST00000396097
ENSMUSP00000106696
ENSMUST00000111067
ENSMUSP00000070583
ENSMUST00000067124
ENSRNOP00000005863
ENSRNOT00000005863

MGI ID MGI:1891340

RGD ID 1307646

Unigene ID Hs.467740
Hs.739141
Mm.153625
Rn.229137

Homologene ID 9266