URN | urn:agi-llid:28953 |
---|---|
Total Entities | 0 |
Connectivity | 3780 |
Name | FOXP3 |
Description | forkhead box P3 |
Notes | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Nucleus |
Class | Transcription factor |
Pathway | T-Cell Maturation (Hypothesis) |
---|---|
Treg-Cell Differentiation | |
AHR Signaling in Treg and Dendritic Cells Function | |
Kynurenine/AHR Signaling in Treg Cell Activation | |
Proteins Involved in Atherosclerosis | |
Dendritic Cells Function in Atherosclerosis | |
Lymphocyte Mediated Myocardial Injury in Myocarditis | |
Proteins Involved in Melanoma | |
T-Cells Differentiation Block in Psoriasis | |
Proteins with Altered Expression in Psoriasis | |
Treg-Cell Function in Diabetes Mellitus Type 1 | |
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1 | |
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model) | |
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1 | |
Proteins Involved in Diabetes Mellitus Type 1 | |
Treg-Cell Activation in Diabetes Mellitus | |
Neonatal Diabetes Mellitus | |
Proteins Involved in Celiac Disease | |
Th17-Cell Activation in Crohn's Disease | |
Proteins Involved in Inflammatory Bowel Diseases | |
Autoimmune Polyglandular Syndromes Progression (Hypothesis) | |
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway | |
Proteins Involved in Endometriosis | |
Proteins Involved in Chronic Obstructive Pulmonary Disease | |
CD80 -> AP-1 Expression Targets | |
CD81 Expression Targets | |
Elevated Receptors -> Expression Targets in Colon | |
Elevated Receptors -> Expression Targets in Appendix | |
STAT3 Facilitates the Function of Treg Cells and Cancer Progression | |
Treg Cells Promote Immunosuppression in Cancer Immune Escape | |
Effector T-cell Inactivation in Cancer Immune Escape | |
Adenosine/cAMP Promote Immunosuppression by Treg Cells | |
IL15 Expression Targets | |
IL6 Expression Targets | |
IL4 Expression Targets | |
IL2 Expression Targets | |
LDLR -> Expression Targets in Lymphoid System and Blood | |
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood | |
NOTCH -> Expression Targets in Thymus | |
Elevated Receptors -> Expression Targets in Thymus | |
PDCD1 -> STAT Expression Targets | |
PDCD1 -> NFATC Expression Targets | |
PDCD1 -> AP-1 Expression Targets | |
TCR -> NFAT Expression Targets | |
TCR -> STAT Expression Targets | |
TGFB1-TGFBR1 Expression Targets | |
TGFB1-ACVRL1 Expression Targets | |
PPAR Psoriasis | |
pprarg neg, uknown targets, ps-positive | |
Model of PPARG signaling in psoriasis | |
PPARG negative regulators and targets | |
Model of PPARG related pathways in psoriasis (short version) | |
Figure 3_Mixed network of dexamethasone targets | |
Figure 3_Mixed network of dexamethasone targets | |
1_Differentiation of psoriatic T cells | |
4_1_Polymorphisms associated with inflammatory bowel diseases | |
2_Defective tolerance of autoreactive T-cell in T1D | |
Model of PPARG signaling in psoriais (tested) | |
before laser treatment | |
Differentiation of psoriatic T cells | |
Anti-psoriatic drugs influence PPARG signaling | |
PPARG signaling after laser treatment |
Group | Genes with Mutations Associated with Diabetes Mellitus Type 1 |
---|---|
Genes with Mutations Associated with Neonatal Diabetes Mellitus |
MedScan ID | 28953 |
---|
LocusLink ID | 28953 |
---|---|
50943 | |
20371 | |
317382 |
Alias | RP23-54C14.1 |
---|---|
JM2 protein | |
OTTHUMP00000025832 | |
XPID | |
FOXP3 transcription factor | |
RGD1562112 | |
FOXP3delta7 | |
scurfy | |
MGC141963 | |
MGC141961 | |
OTTHUMP00000025833 | |
FOXP3 | |
immunodeficiency, polyendocrinopathy, enteropathy, X-linked locus | |
Zinc finger protein JM2 | |
PIDX | |
OTTMUSP00000017962 | |
OTTMUSP00000017961 | |
Scurfins | |
transcription factor FOXP3 | |
forkhead box P3, scurfy | |
OTTMUSP00000017952 | |
AIID | |
forkhead box P3 | |
X-linked immunodeficiency, polyendocrinopathy, enteropathy gene | |
Scurfin | |
X-linked immune dysregulation, polyendocrinopathy, enteropathy gene | |
DIETER | |
JM2 | |
IPEX | |
immune dysregulation, polyendocrinopathy, enteropathy, X-linked | |
immunodeficiency, polyendocrinopathy, enteropathy, X-linked | |
forkhead box protein P3 | |
sf |
GO ID | 0003677 |
---|---|
0003700 | |
0000981 | |
0051059 | |
0051525 | |
0000978 | |
0035035 | |
0042826 | |
0046872 | |
0042803 | |
0043565 | |
0003714 | |
0001782 | |
0002362 | |
0042110 | |
0043029 | |
0002456 | |
0050852 | |
0006338 | |
0001816 | |
0002262 | |
0032792 | |
0043433 | |
0032088 | |
0002725 | |
0042130 | |
2000320 | |
0046007 | |
0008285 | |
0002677 | |
0042036 | |
0050710 | |
0035067 | |
0031064 | |
0050777 | |
0045077 | |
0032689 | |
0032693 | |
0032700 | |
0045085 | |
0032703 | |
0032713 | |
0032714 | |
0032715 | |
0048294 | |
0000122 | |
0045892 | |
0032720 | |
0032831 | |
0002669 | |
0035066 | |
0033092 | |
0032753 | |
0002851 | |
0045944 | |
0045893 | |
0032914 | |
0002667 | |
0030111 | |
0048302 | |
0045589 | |
0006355 | |
0009615 | |
0002513 | |
0005737 | |
0005654 | |
0005634 | |
0032991 | |
0003676 | |
0002361 | |
0010629 | |
0050728 | |
0050672 | |
0002666 | |
0010628 | |
0045591 | |
0002637 | |
0006357 | |
0002507 | |
0045066 | |
0005622 | |
0006351 | |
0003705 | |
0001047 | |
0043234 | |
0009653 | |
0030154 | |
0006366 | |
0008301 | |
0003682 | |
0003690 | |
0046982 | |
0008270 | |
0043010 | |
0021757 | |
0021549 | |
0021987 | |
0009790 | |
0040007 | |
0048286 | |
0007389 | |
0060501 | |
0002053 | |
0009791 | |
0021758 | |
0060013 | |
0007519 | |
0048745 | |
0042297 | |
0005667 |
KEGG ID | hsa:50943 |
---|---|
mmu:20371 | |
rno:317382 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | X 3.41 cM |
---|---|
X 2.1 cM |
OMIM ID | 300292 |
---|---|
304790 | |
222100 |
Rat chromosome position | Xq12 |
---|---|
Xq13 |
Hugo ID | 6106 |
---|---|
HGNC:6106 |
Human chromosome position | Xp11.23 |
---|
Swiss-Prot Accession | Q9BZS1 |
---|---|
B7ZLG1 | |
Q9BZS1.1 | |
Q53Z59 | |
Q99JB6 | |
Q99JB6.1 | |
D3ZKI1 | |
D4Q8I2 | |
A5HJT1 | |
B7ZLG0 | |
B9UN80 | |
O60827 | |
Q14DD8 | |
Q4ZH51 |
Swiss-Prot ID | FOXP3_HUMAN |
---|---|
FOXP3_MOUSE |
Cell Localization | Nucleus |
---|---|
Cytoplasm |
Ensembl ID | ENSG00000049768 |
---|---|
ENSP00000365372.2 | |
ENST00000376199.7 | |
ENSP00000365380.4 | |
ENST00000376207.9 | |
ENSP00000396415.3 | |
ENST00000455775.7 | |
ENSP00000451208.1 | |
ENST00000557224.6 | |
ENSMUSG00000039521 | |
ENSMUSP00000111405.1 | |
ENSMUST00000115740.8 | |
ENSMUSP00000111403.1 | |
ENSMUST00000115738.7 | |
ENSMUSP00000111404.1 | |
ENSMUST00000115739.8 | |
ENSRNOG00000011702 | |
ENSRNOP00000015641.4 | |
ENSRNOT00000015641.6 | |
ENSRNOP00000073801.1 | |
ENSRNOT00000077391.1 | |
ENST00000376199.6 | |
ENST00000557224.5 | |
ENSMUST00000115739.7 | |
ENST00000455775.6 | |
ENST00000376207.8 | |
ENSMUST00000115740.7 | |
ENSP00000365372 | |
ENST00000376199 | |
ENSP00000365380 | |
ENST00000376207 | |
ENSP00000396415 | |
ENST00000455775 | |
ENSMUSP00000111405 | |
ENSMUST00000115740 | |
ENSMUSP00000111403 | |
ENSMUST00000115738 | |
ENSMUSP00000111404 | |
ENSMUST00000115739 | |
ENSRNOP00000015641 | |
ENSRNOT00000015641 | |
ENSRNOP00000073801 | |
ENSRNOT00000077391 |
MGI ID | MGI:1891436 |
---|---|
1891436 |
RGD ID | 1562112 |
---|
Unigene ID | Mm.182291 |
---|---|
Mm.288192 | |
Rn.177272 | |
Hs.247700 |
Homologene ID | 8516 |
---|
Shape | O-vertex |
---|
IPI ID | IPI00115123 |
---|---|
IPI00328094 | |
IPI00604500 | |
IPI00644203 |