Protein PLCG1

URN urn:agi-llid:5335
Total Entities 0
Connectivity 2314
Name PLCG1
Description phospholipase C, gamma 1
Notes The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm

Pathway Skin Aging
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Dopamine Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Dopamine Synthesis and Release
Thrombopoietin Receptors Signaling in Platelet Maturation
T-Cell Independent B-Cell Activation
V(D)J Recombination Activation
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Inhibitory Receptor Signaling
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
Peripheral T-Cell Tolerance
T-Cell Central Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Eat me Signal: Apoptotic Cell Induces Phagocytosis
Basophil Activation
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
Neutrophil Activation via Adherence on Endothelial Cells
Vascular Endothelial Cell Activation by NO
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Potassium Flux Regulation
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
Ca2+ Flux Regulation
CRH -> Synthesis of Corticosteroids
DRD2 Expression Targets
DRD2/4 -> Membrane Transport
NTRK1/2/3 -> Acetylcholine Production
EPHB -> NMDA Receptor Activation
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
G0/G1 Phase Transition
Th1-Cells Activation and Proliferation in Atherosclerosis
Dilated Cardiomyopathy
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Lymphocyte Mediated Myocardial Injury in Myocarditis
Neurons Necrosis Caused by Energy Deficiency
Contraction Due Vasospasm
Sebocyte Proliferation in Acne Vulgaris
Atopic Dermatitis Onset
Cell Cycle Dysregulation in Melanoma
WNT Signaling in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th17-Cell Function in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Proliferative Diabetic Retinopathy
Immune Sustem Activation in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
RET1 Mutation in Hyperparathyroidism
Cardiovascular Effects in Hyperthyroidism
Immune System Activation in Hyperthyroidism
Hypothyroidism, Secondary (Central)
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
B-Cell Activation in Crohn's Disease
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Independent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Hodgkin Lymphoma
T-Cell Acute Lymphoblastic Leukemia
Goblet-Cell Exocytosis in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Osteoclast Activation in Gout
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Th2-Cells Function in Systemic Scleroderma
Dentin Formation Disruption
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
BDNF Upregulation Triggered by Seizures
Glioblastoma, Primary
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Dopamine Synthesis and Release in Migraine
Postsynaptic Neuron Activation
Brain Cell Necrosis in Vascular Dementia
Angiogenesis in Endometriosis
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
Ca2+ Toxicity in Lens Cells
VEGFA in Neovascular Glaucoma
Cytokines Trigger Otitis Media
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
Penile Detumescense Augmentation Mechanisms
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD157 -> cADPR/Calcium Signaling
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Dopamine/Gi Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
SELE -> ELK-SRF Signaling
CD2 Expression Targets
CD247 Expression Targets
FCGR3A Expression Targets
CD22 -> NF-kB Expression Targets
CD8 -> AP-1 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD72 -> NF-kB Expression Targets
CD72 -> STAT Expression Target
CD8 -> ATF/CREB/CREBBP Expression Targets
CD8 -> NF-kB Expression Targets
CD8 -> STAT Expression Targets
CD80 -> AP-1 Expression Targets
CD80 -> STAT Expression Targets
CD81 Expression Targets
CD80 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD86 -> NFATC Expression Targets
CD86 -> STAT Expression Targets
CD86-> NFATC Expression Targets
CD86 -> NF-kB Expression Targets
Doxorubicin Induced Cardiotoxicity
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FPR1 -> Cytoskeleton Signaling
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
G0/G1 Cell Cycle Phase Transition Activation in Cancer
VEGF Independent Angiogenesis in Cancer
CDH2 Activation Promotes Cancer Cell Migration and Survival
CFL1 in Cancer Cell Motility
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
CD2 -> NFATC1 Signaling
FcIgER -> NFATC1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL16 -> AP-1 Expression Targets
IL16-> ATF/CREB/CREBBP Expression Target
IL16 -> NF-kB Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
LPA Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
PDCD1 -> ATF/CREB/CREBBP Expression Targets
PDCD1 -> NF-kB Expression Targets
PDCD1 -> NFATC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
AXL Receptor Tyrosine Kinase Signaling
VEGF Signaling
EGFR Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> NFAT Expression Targets
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
T-Cell Receptor -> NF-kB Signaling
T-Cell Receptor -> NFATC Signaling
T-Cell Receptor -> CREBBP Signaling
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Ca2+ Cytosolic Overload
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
sialic
cypa
Model of PPARG signaling in psoriasis
New Pathway
2_Hyperseborrhea in acne vulgaris
1_The onset of atopic dermatitis
3_Enhanced angiogenesis in endometriosis
2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
2_Pathogens stimulate mucins expression in the middle ear
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
3_Islet beta-cell destruction in T1D
2_1_General pathways of thyroid hormone signaling
drug-target pairs binding

Source curated
GO component
Biopax

MedScan ID 5335

LocusLink ID 5335
18803
25738
381402
99130
12547
281987
373867
336067
336221

Alias phospholipase C-II
PIG1_HUMAN
PLC-II
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma I
PLCgamma1
PLC-gamma I
Phospholipase C-gamma
AI894140
Phospholipase C-gamma I
Plcg I
NCKAP3
phospholipase C-148
OTTMUSP00000017125
PPLCA
PLC148
RP23-393F23.4
PLC1
LOC381402
phosphoinositide phospholipase C-gamma-1
OTTHUMP00000178982
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
PLC I
OTTHUMP00000031787
PLC-gamma
PLCG1
OTTMUSP00000001135
PIG1_RAT
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
PLC-148
PLC-gamma-1
inositoltrisphosphohydrolase
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
phosphoinositidase C
phosphoinositide phospholipase C
phospholipase C, gamma 1 (formerly subtype 148)
triphosphoinositide phosphodiesterase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Cded
Plc-1
Plcg-1
Plc-gamma1
cell differentiation and embryonic development
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
phospholipase C-gamma-1
phospholipase C gamma 1
RP3-511B24.2
PIG I
PIG1
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate phosphodiesterase
PLC-148s
phospholipase C, gamma 1
cell differentiating and embryonic development

EC Number 3.1.4.11
3.1.4.3

GO ID 0005509
0035254
0005168
0004435
0004629
0019901
0030971
0038095
0038096
0050852
0007202
0007411
0019722
0016477
0071364
0007173
0001701
0043647
0032959
0050900
0050804
0048015
0009395
0045766
0043536
2000353
0010634
0010863
0051281
1905564
0051209
0007165
0016032
0008180
0098685
0042995
0005911
0005737
0005829
0098978
0030027
0005886
0001726
0016787
0005158
0046872
0051219
0008081
0006816
0035556
0016042
0006629
0009306
1901339
0030136
0043005
0009629
0042542
0043278
0010243
0005057
0000186
0004871
0007596
0019221
0008543
0045087
0048011
0044281
0048010
0019048
0005543
0005622
0044419
0032236
0023034
0016192
0007242
0005575
0005515
0008372
0001570
0008016
0031101

KEGG ID hsa:5335
mmu:18803
rno:25738

MedLine Reference 10913276
11724770
11823862
11886851
11989979
12009430
12437926
12507498
12623065
12646582
12850505
12930795
14523024
14568990
14570902
15060019
15161916
15169852
15252117
15258148
15536495
15579910
15607032
15607753
15744307
16819285
16841466
16989733
2840660
9892736
10191086
10349636
10373493
11042159
11076861
11217851
11438667
11544199
11562428
11744703
11748152
11916959
11931670
11934646
11973363
12061819
12065840
12149210
12374739
12466851
12477932
12761849
12909648
13129935
1358284
1409582
14612947
14687726
15006698
15062102
15121188
15196926
15214048
15329338
15367584
15372077
15563458
15595842
15657076
15782199
15817477
15944397
15953601
16141072
16141073
16319178
16537572
16571757
16670015
17015722
17114464
17128263
2033248
7744830
7774933
7781998
8672127
8687404
8739298
8889548
9096335
9472710
9529375
9662423
9685408
9691180
10350061
10430888
10455176
10467411
10473113
10501179
10586033
10652211
10692392
10770799
10783152
10823839
10843712
10873601
10899172
10926122
10940929
10980614
11043766
11071635
11094073
11259588
11312102
11368773
11390470
11390650
11409699
11779129
11941371
11956228
12071848
12084069
12085993
12163161
12419535
12454018
12482669
12496421
12514734
12598525
12601080
12771140
12788694
12845332
12890670
12937273
12960351
1383690
14647465
14702343
14722116
14989173
1500851
15123640
15144186
15153499
15184383
15556869
15623534
15654973
15766521
15872086
15951569
15972651
15996687
16341594
1639386
1676673
1683701
1689310
16921170
17023658
17111345
17130290
1715690
2167438
3254788
7510703
7512571
7513258
7518429
7535778
7536744
7589147
7629168
7657612
7681365
7682059
7761838
7799925
7999363
8084603
8155326
8290562
8384556
8386518
8443409
8596638
8627166
8628282
8657103
8660853
8662733
8885868
8892607
8905292
8910519
8918464
8995379
9164868
9174053
9178760
9207933
9231720
9278385
9281317
9299537
9314836
9344857
9398617
9489702
9516477
9535722
9600074
9697839
9712732
9729044
9730685
9743338
9891995
15532540
15879121
1689311
1708307
17116690
2831461
8181064
11997344
12782653
15256591
15998812
16565716
17309817
10488157
11780052
15270728
15592455
15702972
17081983
17148460
17242406
17372230
17419608
17561374
17562871
9045685
10646608
12471105
15308098
15489334
16380231
17531443
16973916
17252537
17432954
17524370
8106527
8183574
8392838
8402898
8910399

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 2 80.97 cM
2 92.0 cM

OMIM ID 172420

Rat chromosome position 3q42

Hugo ID 9065
HGNC:9065

Human chromosome position 20q12
20q12-q13.1

Swiss-Prot Accession P19174
Q4LE43
Q9UFY1
P19174.1
Q62077
Q62077.2
P10686
P10686.1
B7ZLY7
B9EGH4
E1P5W4
Q2V575
Q6P1G1
A2A284
A2A4A7
Q6LC80
Q2M4I9
Q3TE89
Q3TUJ5
Q3UZ68
Q792T1
Q9Z2S5
PLCG1_HUMAN
PLCG1_MOUSE
PLCG1_RAT
A2A284_HUMAN
Q4LE43_HUMAN
A2A4A7_MOUSE
Q9BQY5

PIR ID A36466
A31317
T14776

GenBank ID NC_000020
XR_001754293
XR_001754294
XR_001754295
XR_001754296
XM_005260438
XP_005260495
XM_011528867
XP_011527169
NM_002660
NP_002651
NM_182811
NP_877963
XM_011528865
XP_011527167
AL022394
CH471077
EAW75989
EAW75990
EAW75991
EAW75992
EAW75993
DQ297143
ABB84466
U80983
AAB70663
AB210028
BAE06110
AF147391
AK297370
BAG59815
AK309606
AL110247
CAB53696
BC136466
AAI36467
BC144136
AAI44137
BX415739
BX434193
M34667
AAA36452
P19174
NC_000068
NM_021280
NP_067255
AH007341
AAD13798
AL590389
AY902326
AAX90611
CH466551
EDL06290
EDL06291
EDL06292
HB877232
CBF62965
HB895866
CBF74731
HC934641
CBU87841
HC953275
CBU96788
AF027185
AAD09344
AK134041
BAE21990
AK160731
BAE35976
AK162809
AK169695
BAE41310
AK169777
BAE41359
AK185701
BC057161
BC065091
AAH65091
X95346
CAA64639
Q62077
NC_005102
NM_013187
NP_037319
AC_000071
AAHX01026215
AC128986
CH474005
EDL96614
EDL96615
J03806
AAA41921
P10686
XR_936550
XM_011528866
XP_011527168
NC_018931
AMYH02037082
AMYH02037083
AC_000024
AAHY01012440
XR_244143
AC_000152
ABBA01052574
AABR06027396
CAA18537
CAM28260
CAM23067
CAM23068
CAM23069
NT_011362
NW_001838666
NW_927339
AC_000063
Q4LE43
Q6LC80
Q9UFY1
NT_039207
NW_001030712
AF027186
AF027187
Q2M4I9
Q3TE89
Q3TUJ5
Q3UZ68
Q792T1
Q9Z2S5
NW_047659
NW_001084817
Q9BQY5
BM121087
CAC36283
NW_000179
130226
206324
4103747
4103753
123782930
123788798
123793748
123796465
1246803
40675439
62635484
74137194
74141388
74146600
74146760
81870156
81894283
85700388
AI894140
119596396
119596397
119596398
121948502
130225
190038
2408215
3336979
5817197
68533111
74709702
74752259
74753302
82583660
NT_086910
130224
639
CAA68406
NC_007311
NM_174425
NP_776850
NW_001493162
P08487
Y00301
AW279908
AW280848
AW281486
AW281801
27883903
27883905
27883907
82098722
82098725
82098727
AAO23907
AAO23908
AAO23909
AY163168
AY163169
AY163170
NC_007134
NM_194407
NP_919388
NW_001512488
Q804J4
Q804J5
Q804J6
119596395
119596399
123236076
148674343
148674344
148674345
149043040
149043041

Swiss-Prot ID PLCG1_HUMAN
PLCG1_MOUSE
PLCG1_RAT
Q9UFY1_HUMAN
A2A284_HUMAN
A2A4A7_MOUSE
Q4LE43_HUMAN

Cell Localization Cell projection
Lamellipodium
Ruffle
Cell projection, lamellipodium
Cell projection, ruffle
Plasma membrane
Cytoplasm

Ensembl ID ENSG00000124181
ENSP00000244007.3
ENST00000244007.7
ENSP00000362368.1
ENST00000373271.5
ENSMUSG00000016933
ENSMUSP00000099404.1
ENSMUST00000103115.7
ENSRNOG00000051490
ENSRNOP00000069822.1
ENSRNOT00000078909.1
ENSP00000244007
ENST00000244007
ENSP00000362368
ENST00000373271
ENSMUSP00000099404
ENSMUST00000103115
ENSRNOP00000069822
ENSRNOT00000078909
ENSRNOG00000016340
ENSRNOP00000022276
ENSRNOT00000022276
ENSP00000362369
ENST00000373272

MGI ID MGI:97615
97615
1329022
2139113

RGD ID 3347

Unigene ID Hs.268177
Mm.44463
Rn.11243
Bt.307
Dr.120304

Homologene ID 1997

IPI ID IPI00192532
IPI00016736
IPI00383849
IPI00121089
IPI00745182
IPI00653317
IPI00654932
IPI00757004
IPI00753388
IPI00212420

Microarray ID 98290_at

Homo sapiens Chromosome position 20q12-q13.1

Ensembl Transcript ID ENST00000373272
ENST00000244007
ENST00000373271

ENSEMBL ENSG00000124181

FunctionalClass insulin receptor binding
phosphoinositide phospholipase C
phospholipase C
protein binding
receptor signaling protein
calcium ion binding
hydrolase
signal transducer
phosphoprotein binding

Bos taurus Chromosome position 13

Mus musculus Chromosome position 2 93.0 cM
2 92.0 cM
2 H2

KEGG pathway Calcium signaling pathway
ErbB signaling pathway
Fc epsilon RI signaling pathway
Glioma
Inositol phosphate metabolism
Leukocyte transendothelial migration
Natural killer cell mediated cytotoxicity
Non-small cell lung cancer
Phosphatidylinositol signaling system
VEGF signaling pathway

Rattus norvegicus Chromosome position 3q42

Ensembl Gene ID ENSG00000124181

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: lymphoid tissue; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: breast; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: cells in granular layer; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebellum; Cell type: Purkinje cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: glial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cervix, uterine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: colon; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: duodenum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: epididymis; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: fallopian tube; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: gall bladder; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: heart muscle; Cell type: myocytes; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: glial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: neuronal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: kidney; Cell type: cells in glomeruli; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: kidney; Cell type: cells in tubules; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: lateral ventricle; Cell type: glial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: bile duct cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: hepatocytes; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: macrophages; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: pneumocytes; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: ovary; Cell type: follicle cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: ovary; Cell type: ovarian stroma cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: islets of Langerhans; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: parathyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: placenta; Cell type: decidual cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: placenta; Cell type: trophoblastic cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: prostate; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: rectum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: salivary gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: seminal vesicle; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: skeletal muscle; Cell type: myocytes; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: small intestine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in red pulp; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in white pulp; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: stomach, lower; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: stomach, upper; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: thyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: urinary bladder; Cell type: urothelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: vagina; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: cervix
uterine; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain

Danio rerio Chromosome position LG 23

EnzymeConsortium 3.1.4.11