Protein IL17RA

URN urn:agi-llid:23765
Total Entities 0
Connectivity 1046
Name IL17RA
Description interleukin 17 receptor A
Notes Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway Natural Killer Cell Precursor -> Natural Killer Cell Surface Expression Markers
IL17 Signaling in Psoriasis
Proteins Involved in Helicobacter Infections
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Proteins Involved in Endometriosis
Cytokines Trigger Otitis Media
IL23A and IL17A Provoke Cancer-Associated Inflammation
sars-cov binding
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_3_Eosinophilia and neutrophilia in asthma: Neutrophil chemotaxis and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Psoriatic Arthritis
binding partnetrs for SARSs

MedScan ID 23765

LocusLink ID 23765
16172
312679

Alias Cdw217
IL17 receptors
IL17R
interleukin 17 receptor A
interleukin IL17 receptors
LOC150166
IL17 receptor
VDw217
interleukin IL17A receptor
HIL-17R
GNB:2826476
interleukin IL17 receptor A
CANDF5
interleukin IL17R
interleukin IL17 receptor
IL17RA
LOC100506204
MGC10262
AW538159
interleukin IL17RA
interleukin 17 receptor
CD217
IMD51
IL-17 receptor A
interleukin 17A receptor
interleukin 17 receptors
IL-17RA
interleukin-17 receptor A

GO ID 0030368
0005102
0007166
0050832
0072537
0071621
0097400
1900017
2000667
0032747
2000664
0005576
0005887
0005886
0071345
0050729
0016021
0016020
0019221

KEGG ID hsa:23765
mmu:16172

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6 56.95 cM

OMIM ID 605461
613953

Rat chromosome position 4q42

Hugo ID 5985
HGNC:5985

Human chromosome position 22q11.1

Swiss-Prot Accession Q96F46
Q96F46.2
Q60943
Q60943.1
D4A740
O43844
Q20WK1

GenBank ID NC_000022
NM_014339
NP_055154
NM_001289905
NP_001276834
NG_028257
AC006946
CH471193
EAW57738
EAW57739
EAW57740
EAW57741
CS399134
CAL44890
GM832013
CAV28582
JA381715
CCB07364
AF021799
AK056836
AK093772
BC011624
AAH11624
BC012071
BE242733
BU585070
BX334547
BX368715
BX410574
CB044543
CT841520
CAJ86450
JF305973
ADY18334
U58917
AAB99730
Q96F46
NC_000072
XM_006505618
XP_006505681
NM_008359
NP_032385
NT_039382
AC007844
AC018559
AC078896
CH466523
EDK99637
EDK99638
AK010040
BAB26660
AK036587
AK080226
BC060219
BY267308
U31993
AAC52357
Q60943
NC_005103
NM_001107883
NP_001101353
AC_000072
AABR07061911
AAHX01032648
CH473964
EDM02034
EDM02035
FQ225026
FQ235042
NC_018933
AMYH02037985
AMYH02037986
DQ891962
ABM82888
DQ895152
ABM86078
XM_006507122
XP_006507185
AC_000028
AAHY01057029
BC146306
AAI46307
BC156651
AAI56652
AC_000154
ABBA01001459

Swiss-Prot ID I17RA_HUMAN
I17RA_MOUSE

Cell Localization Cell membrane
Secreted
Membrane
Plasma membrane

Ensembl ID ENSG00000177663
ENSP00000479970.1
ENST00000612619.1
ENSP00000320936.6
ENST00000319363.10
ENSMUSG00000002897
ENSMUSP00000002976.3
ENSMUST00000002976.4
ENSRNOG00000011153
ENSRNOP00000014885.6
ENSRNOT00000014885.6
ENSP00000479970
ENST00000612619
ENSP00000320936
ENST00000319363
ENSMUSP00000002976
ENSMUST00000002976
ENSRNOP00000014885
ENSRNOT00000014885

MGI ID MGI:107399

RGD ID 1306559

Unigene ID Hs.48353
Mm.4481
Rn.106209

Homologene ID 7378

Shape Stick-vertex