Protein OLR1

URN urn:agi-llid:4973
Total Entities 0
Connectivity 1631
Name OLR1
Description oxidized low density lipoprotein receptor 1
Notes This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Scavenger Receptors in Platelet Aggregation
Proteins Involved in Atherosclerosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Proteins Involved in Diabetic Neuropathy
Proteins Involved in Age-Related Macular Degeneration
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Elevated Receptors -> Expression Targets in Aorta
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
HBEGF -> AP-1/ATF Expression Targets
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
IL6 Expression Targets
IL4 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
AGT -> STAT Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR9 Expression Targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis

MedScan ID 4973

LocusLink ID 4973
108078
140914

Alias Lectin-like oxidized low-density lipoprotein receptor-1
hLOX-1
lectin-like oxidized low-density lipoprotein receptor
LOX-1
LOX-I
oxidized low density lipoprotein (lectin-like) receptor 1
LOXIN
oxidized low density lipoprotein (lectin-like) receptor I
SCARE1
oxidized low-density lipoprotein receptor 1
oxidized LDL receptor 1
Oldlr1
OLR1
lectin-type oxidized LDL receptor I
scavenger receptor class E, member 1
oxidized low-density lipoprotein receptor 1, soluble form
SLOX1
scavenger receptor class E
Oldr1
SR-EI
CLEC8A
Lectin-like OXIDIZED LDL receptors
lectin-like oxLDL receptor 1
scavenger receptor class E, member I
lectin-type oxidized LDL receptor 1
lectin-like oxidized LDL receptor 1
C-type lectin domain family 8 member A
ox LDL receptor 1
Lectin-like OXIDIZED LDL receptor
LOX1
ox-LDL receptor 1
oxidised low density lipoprotein (lectin-like) receptor 1
oxidised low density lipoprotein (lectin-like) receptor I

GO ID 0030246
0008015
0007155
0006954
0050900
0043312
0006508
0005576
0005887
0043231
0016020
0045121
0005654
0005886
0043235
0035579
0070821
0005041
0008219
0002376
0007159
0042157
0010629
0019897
0016021
0097756
0032930
0042542
0016192
0006898
0070062
0004872
0007596
0005634

KEGG ID hsa:4973
mmu:108078
rno:140914

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6

OMIM ID 602601
608446

Rat chromosome position 4q42

Hugo ID 8133
HGNC:8133

Human chromosome position 12p13.2
12p13.2-p12.3

Swiss-Prot Accession P78380
A0A024RAU0
P78380.1
G4WK10
G4WK09
Q9EQ09
Q9EQ09.2
A0A0G2K1K0
O70156
O70156.1
A8K7V9
B4DI48
G3V1I4
Q2PP00
Q7Z484
Q3U3M1

PIR ID JE0111

GenBank ID NC_000012
NM_001172632
NP_001166103
NM_001172633
NP_001166104
NM_002543
NP_002534
NG_016743
AC024224
AC115676
AH007081
AAC97927
AJ131757
CAB38175
AX429256
CAD36117
CH471094
EAW96156
EAW96157
EAW96158
EAW96159
CS443020
CAL68889
DQ314885
ABC40744
JA885104
CCQ77677
AB010710
BAA24580
AB102861
BAC81565
AF035776
AAC82329
AK292124
BAF84813
AK295409
BAG58360
AK298040
BAG60339
AK308009
AK316353
BAH14724
AL551100
AX429248
CAD36113
BC022295
AAH22295
BC055085
BP219342
BQ028409
CA309323
CB955704
P78380
NC_000072
XR_001785081
XM_017321299
XP_017176788
XM_017321300
XP_017176789
NM_001301096
NP_001288025
NM_001301094
NP_001288023
NM_138648
NP_619589
AC161602
CH466523
EDK99928
AF303744
AAG44998
AK154687
BAE32764
AK160919
BX513847
HQ603085
AEQ16487
HQ603086
AEQ16488
Q9EQ09
NC_005103
NM_133306
NP_579840
AC_000072
AABR07073062
AAHX01033064
AAHX01033065
AB018104
BAA35123
AC115156
CH473964
EDM01737
EDM01738
AB005900
BAA25785
BC097290
AAH97290
FQ220710
O70156
XM_011520682
XP_011518984
XM_011520683
XP_011518985
NC_018923
AF079164
AF079165
AF079166
AF079167
AMYH02026023
DQ891409
ABM82335
DQ894585
ABM85511
AC_000028
AAHY01057559
AAHY01057560
AAHY01057561
AAHY01057562
BC148550
AAI48551
XM_006719081
XP_006719144
AC_000144
ABBA01067796
XM_006505303
XP_006505366
XM_006505304
XP_006505367

Swiss-Prot ID OLR1_HUMAN
OLR1_MOUSE
OLR1_RAT

Cell Localization Cell membrane
Membrane raft
Secreted

Ensembl ID ENSG00000173391
ENSP00000405116.2
ENST00000432556.6
ENSP00000439251.1
ENST00000545927.5
ENSP00000309124.3
ENST00000309539.8
ENSMUSG00000030162
ENSMUSP00000138588.1
ENSMUST00000182784.3
ENSMUSP00000138228.1
ENSMUST00000183258.7
ENSMUSP00000032265.6
ENSMUST00000032265.12
ENSRNOG00000056219
ENSRNOP00000071872.1
ENSRNOT00000086390.1
ENSP00000405116
ENST00000432556
ENSP00000439251
ENST00000545927
ENSP00000309124
ENST00000309539
ENSMUSP00000138588
ENSMUST00000182784
ENSMUSP00000138228
ENSMUST00000183258
ENSMUSP00000032265
ENSMUST00000032265
ENSRNOP00000071872
ENSRNOT00000086390
ENSRNOG00000008375
ENSRNOP00000011196
ENSRNOT00000011196

MGI ID MGI:1261434

RGD ID 620515

Unigene ID Hs.412484
Mm.293626
Rn.87449

Homologene ID 1910

Shape Stick-vertex