Protein AKT1

URN urn:agi-llid:207
Total Entities 0
Connectivity 19439
Name AKT1
Description AKT serine/threonine kinase 1
Notes The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Osteoarthritis
Androgen Deficiency in Male Obesity
Oncogene Induced Cellular Senescence
MTHFR Activity Regulation
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Telomer Attrition Triggers Genomic Instability
Insulin Influence on Protein Synthesis
Insulin Influence on Glycogenesis
Insulin Influence on Lipogenesis
Dopamine Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Insulin Signaling
Thrombopoietin Receptors Signaling in Platelet Maturation
Androgens in Adipocyte Activation
LH and FSH Signaling and Steroidogenesis
Toll-like Receptors Act through MYD88-TIRAP Signaling
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
T-Cell Maturation (Hypothesis)
Peripheral T-Cell Tolerance
T-Cell Positive Selection and Neglect Induced Death
T-Cell Central Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
TAM Receptors in Platelet Aggregation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Bradykinin Effects in Inflammation
Platelet Activation via GPCR Signaling
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Eicosanoids in Myeloid Cell Activation
Histamine Receptor H3 Signaling in Neurons
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
VEGFA/NOTCH1/WNT Cross-talk in Blood Vessel Sprouting and Branching in Cancer
Vascular Endothelial Cell Activation by NO
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Vascular Endothelial Cell Permeability Activation
Adipokines Production by Adipocyte
Lipolysis Regulation in Adipocyte
Lipogenesis Regulation in Adipocyte
Synaptic Potentiation by PKMZ in LTP Maintenance - Active State
Nociception Expression Targets Signaling
Sodium Flux Regulation
Vascular Motility
BDKRB1/2 -> Vasodilation
BDKRB1/2 -> Interleukins Production
DRD2 -> TRPC1 Transcription
GALR1/2/3 -> POMC/NPY Production
PTGER2/3 -> Vascular Motility
TACR1 -> TNF/IL6/IL8 Production
Leptin -> NO Production/Vasodilation
Kidney Cells Cilia Organization
Apoptosis
G1/S Phase Transition
Cell Cycle Overiew
G0/G1 Phase Transition
G2/M Phase Transition
Tight Junction Assembly (Occludin)
Adherens Junction Assembly (Cadherins)
Actin Cytoskeleton
Telomere Maintenance
Axonal Transport
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Endothelial Cell Dysfunction in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
BMP2 and WNT Signaling in Pulmonary Artery Smooth Muscle Cells
Myocardial Remodeling
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
Myocarditis, Acute Viral Overiew
Vascular Reactivity in Raynaud Disease
NO Synthesis in Early Vasospasm
Proteins Involved in Acne Vulgaris
Hyperseborrhea in Acne Vulgaris
Androgen Induced Sebocyte Hyperfunction
Androgens in Sebocyte Maturation
Atopic Dermatitis Onset
Proteins Involved in Ichthyosis
Melanoma
Apoptosis Block in Melanoma Cell
Dedifferentiation and Metastatic Progression in Melanoma
Proteins Involved in Melanoma
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Dendritic Cells Function in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Proteins Involved in Diabetes Mellitus Type 2
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Glucocorticoids in Insulin Resistance in Skeletal Muscles
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
AGE Related Insulin Resistance in Skeletal Muscles
Adiponectin in Insulin Resistance Prevention
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Proteins Involved in non-Alcoholic Fatty Liver Disease
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
PNPLA3 in non-Alcoholic Fatty Liver Disease
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
Leptin in Insulin Synthesis and Secretion
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Mass Regulation
beta-Cell Function Inhibition by Ciclosporine and Tacrolimus (Rodent Model)
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
RET1 Mutation in Hyperparathyroidism
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
Graves Ophthalmopathy
Immune System Activation in Hyperthyroidism
Myocyte Dysfunction in Hypoparathyroidism
GLIS3 Targets in Thyroid Dysgenesis (Hypothesis)
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thymic Follicular Hyperplasia
Adipocyte Hypertrophy and Hyperplasia
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
CD4+T-Cell Response in Celiac Disease
Enterocyte Mediated Mucosal Damage in Celiac Disease
Proteins Involved in Colorectal Neoplasms
Cetuximab Resistance in Colorectal Cancer
Metastatic Colorectal Cancer
GUCY2C Signaling in Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
Peutz-Jeghers Syndrome
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Proteins Involved in Acute Myeloid Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
B-Cell Acute Lymphoblastic Leukemia
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Proteins Involved in Diffuse Large-B-Cell Lymphoma
Lymphoma, GCB Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Proteins Involved in Mantle Cell Lymphoma
Mantle Cell Lymphoma
Cell Cycle Dysregulation in Mantle Cell Lymphoma
Apoptosis of Mantle Cell Deregulation
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Hedgehog Signaling in Mantle Cell Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in Multiple Myeloma
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
STK11 Signaling in Pancreatic Neoplasms
Il17 Signaling Related Neutrophilia in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
B-Cell Mediated IgE Production in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Osteoclast Activation in Gout
Proteins Involved in Osteoarthritis
Proteins Involved in Polycystic Ovary Syndrome
Ovulation Block
SHBG and IGFBP1 Synthesis Decline in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
WHIM Syndrome
CD4+ T-Cell Function Decline in HIV
Macrophage Survival through CCR5 and CXCR4 Mediated Signaling
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
Familial Cold Autoinflammatory Syndrome 2
Hereditary Hemorrhagic Telangiectasia
Cowden Syndrome
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
Huntingtin Mutant Protein Toxicity Effects
Proteins Involved in Huntington Disease
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
IGF1 Role in Muscle Hypertrophy
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
Proteins Involved in Alzheimer's Disease
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Glioblastoma, Primary
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Astrocytoma
Glioma Invasion Signaling
Proteins Involved in Glioma
Glioma Stem Cell Program Activation
Ependymoma
Medulloblastoma
Proteins Involved in Medulloblastoma
Vascular Endothelial Cell Vasodilation in Brain
Dopamine Action in CSD Progression
Postsynaptic Neuron Activation
nNOS (NOS1) and iNOS (NOS2) Activation via Glutamate
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
Sonic Hedgehog Signaling in Neuroblastoma
Proteins Involved in Neuroblastoma
Glutamate Role in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Proteins Involved in Amyotrophic Lateral Sclerosis
Glutamate Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
MIR155 Role in Th17-Cell in Multiple Sclerosis
SPP1 Induced Survival of Myelin Specific T-Cells in Multiple Sclerosis
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
WNT Signaling in Breast Cancer
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins with Altered Expression in Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Proteins Involved in Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins with Altered Expression in Endometrial Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Genes with Mutations Associated with Hereditary Breast and/or Ovarian Cancer Syndrome
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
Proteins with Altered Expression in Ovarian Cancer
Proteins Involved in Primary Ovarian Insufficiency
LH and FSH Signaling Impairment in Primary Ovarian Insufficiency
FOXO3 and PTEN Inactivation in Premature Ovarian Failure (Mouse Model)
MIF Role in Cholesteatoma
EGF/cyclinD1 Signaling in Acquired Middle Ear Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
Fatty Acid Synthase (FASN) Signaling
Prostate Cancer
Androgen Receptor/Protein Kinase C-delta Signaling
Proteins Involved in Prostate Cancer
EPHA2 Mutations in Cataract
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Glutamate Mediated Excitotoxicity in Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Proteins Involved in Congenital Deafness
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Polycystins Mutation Effects in Cystic Kidney Disease
Penile Erection Impairment
Advanced Glycation End Products in Diabetes or Age Related Erectile Dysfunction
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Proteins with Altered Expression in Prostate Cancer
Ammonia Effects on Brain Cells
CD157/ITGB2 Signaling in Myeloid Cell
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100B Expression Targets
AREG -> HIF1A Expression Targets
AREG -> FOXO3A Expression Target
Noradrenaline/Gs Expression Targets
Epinephrine/Gs Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
AGTR1 -> ARRB1/ARRB2 Signaling
INSR -> ARRB2/AKT/SRC Signaling
Hedgehog Family -> ARRB1/ARRB2 Canonical Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD19/CR2 Expression Targets
CCL3L1 Expression Target
CCL5 Expression Targets
CCL7 Expression Target
IL8 Expression Targets
Tamoxifen Induced Endometrial Cancer
Dexamethasone Induced Diabetes
Dexamethasone Induced Osteoporosis
Doxorubicin Induced Cardiotoxicity
Ritonavir Induced Diabetes
Clozapine Induced Granulocytopenia
Cyclosporine Induced Nephrotoxicity
EGF -> HIF1A Expression Targets
EGF -> FOXO3A Expression Targets
EGFR/ERBB2 -> HIF1A Signaling
EREG -> FOXO3A Expression Target
EREG -> HIF1A Expression Target
Erythropoietin -> FOXO3A Expression Targets
Erythropoietin -> NF-kB Expression Targets
PECAM1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF2 -> FOXO3A Expression Targets
FGF7 -> FOXO3A Expression Target
FGF10 -> FOXO3A Expression Target
FSHR Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> FOXO3A Expression Target
HBEGF -> HIF1A Expression Targets
HGF -> FOXO3A Expression Targets
HGFR -> FOXO3A Signaling
TAM Receptor Signaling Activation in Cancer
PI3K/AKT/MTOR Signaling Activation in Cancer
Hedgehog Signaling Activation in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
Hedgehog Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
Hippo/YAP1 Signaling Deregulation in Cancer
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
Genes with Mutations in Cancer-Associated Resisting to Cell Death
Apoptosis Evasion in Cancer: Overview
Hypoxia-Induced Cell Death Evasion in Cancer
Apoptosis Block by BCL2 Family Proteins in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
Inhibition of THBS1 Activates Angiogenesis in Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
HIF1A as Master Regulator of Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
MTOR/TORC in Cancer Cell Motility and Invasion
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Invadopodia Formation in Cancer Cells
Metabolic Reprogramming in Cancer: Overview
Skeletal Muscle Wasting in Cancer Cachexia
Metabolic Effects of Oncogenes and Tumor Suppressor in Cancer Cells
Lipogenesis/Lipolysis Activation in Cancer Cells and Cancer-Associated Adipocytes
Glycolysis Activation in Cancer (Warburg Effect)
Genes with Mutations in Cancer Metabolic Reprogramming
Proteins with Altered Expression in Cancer Metabolic Reprogramming
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
EZH2 Methyltransferase Role in Cancer
DNMT and MBD Families Activation in DNA Methylation in Cancer
IGF1 -> CEBPA/FOXO1A Expression Targets
IGF2 -> CEBPA/FOXO1A Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
CD19 -> NF-kB Signaling
AGER -> NF-kB Signaling
ICAM2 -> CTNNB/FOXO/STAT3 Signaling
InsulinR -> CTNNB/FOXA/FOXO Signaling
InsulinR -> ELK/SRF/SREBF Signaling
IGF1R -> CEBPA/FOXO1A Signaling
FibronectinR -> CTNNB Signaling
FibronectinR -> NF-kB Signaling
MacrophageR -> CEBPB -> NF-kB Signaling
Fibronectin Expression Targets
CTGF -> FOXO3A Expression Target
ICAM1 Expression Targets
Fibrinogen Expression Targets
IL7R -> FOXO/NF-kB Signaling
IL15R -> NF-kB/NFATC Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL7 Expression Targets
IL15 Expression Targets
IL12B Expression Targets
PAF/Gq -> NF-kB Expression Targets
Elevated Receptors -> Expression Targets in Lymph Node
CD Markers -> Expression Targets in Lymphoid System and Blood
NRG1 -> FOXO3A Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NOTCH -> NF-kB Signaling
DLL4 Expression Targets
ADAM17 Expression Targets
JAG1 Expression Targets
DLL1 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
PDGFB -> FOXO3A Expression Target
PDGF -> FOXO3A Expression Targets
PDGFR -> FOXO3A Signaling
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
PDCD1 -> STAT Expression Targets
GUCYC2 Signaling
DDR1 -> NF-kB Signaling
AngiopoietinR -> FOXO Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> FOXO/MYCN Signaling
CSF1 -> FOXO3A Expression Targets
Collagen -> NF-kB Expression Targets
GDNF -> HSF1 Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
MERTK Signaling
Ras Signaling
TGF-beta Signaling
AXL Receptor Tyrosine Kinase Signaling
PI3K/RAC1 Signaling
mTOR Signaling
TNF-alpha/TNFRSF1B Signaling
KRAS Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
HRAS Signaling
Hedgehog Family Signaling
T-Cell Receptor -> NF-kB Signaling
TGFA -> FOXO3A Expression Targets
TGFA -> HIF1A Expression Targets
TNFSF10 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13B Expression Targets
TNF -> STAT Expression Targets
TNFRSF5/13B -> NFATC1 Signaling
Thrombopoietin -> SPI1 Expression Targets
Thrombopoietin -> FOXO3A Expression Target
TLR1 -> 2/6 Expression Targets
TLR1/2/6 -> NF-kB Signaling
ER Stress (Unfolded Protein Response)
Glutamate Mediated Neurotoxicity
Ca2+ Cytosolic Overload
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
VEGFC -> CTNNB Expression Target
VEGFA -> FOXO3A Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
VEGFR -> CTNNB Signaling
VEGFR -> FOXO3A Signaling
n
ace2
cypa
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
New Pathway (4)
H2A-K120, H2A-K119 and H3-K4
Epigenetic Modifications of H2A-K120, H2A-K119 and H3-K4
3_Increased proliferation of sebocytes in acne vulgaris
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_Osteoclast-mediated bone resorption in postmenopausal women
2_Osteoblast-mediated bone demineralization
3_TGFB signaling provokes endochondral ossification with osteophyte formation
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
3_Arterial wall inflammation and calcification in atherosclerosis
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
2_Cardiomyocyte hypertrophy
4_Endothelial cells repress vasoconstriction in hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Triglyceride storage in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
4_Tax-induced disruption of the G1/S transition in HTLV-1 infected T-cell
2_HIV - induced depletion of CD4+ T-cells
3_1_Beta-cell proliferation and compensation: proliferation
1_1_Insulin synthesis and secretion: insulin processing and storage
3_3_Beta-cell proliferation and compensation: recovery
4_2_Insulin resistance: inflammation-related insulin resistance
4_1_Insulin resistance: insulin signaling
4_3_Insulin resistance: FFA-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
1_Microangiopathy in diabetic neuropathy
2_Neuron and Schwann cell death
1_Glutamate and calcium excitotoxicity of motor neurons in ALS
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
2_1_General pathways of thyroid hormone signaling
drug-target pairs direct regulation
New Combined Pathway
Model of PPARG signaling in psoriais (tested)
DIPG overview_1 (histones)
DIPG non histone mutations
DIPG histone 3 mutations
New Pathway
DIPG overview_2
HRAS->RAF->MAPK1/3
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Ageing (non-Mammalian Animal Model)
Proteins Involved in Cowden Syndrome
Genes with Mutations Associated with Cowden Syndrome

Source curated
ResNet
GO component
Biopax

MedScan ID 207

LocusLink ID 207
11651
24185
50586
280991
569086
201
268604
111651
210766

Alias Akt kinase
v-akt murine thymoma viral oncogene homolog 1
Akt/PKBs
RAC protein kinase alpha RAC-PK alpha
6.1a protein
Akt
related to A and C kinases
OTTMUSP00000022947
thymoma viral proto-oncogene
rac protein kinase alpha
MGC29148
CWS6
C-AKT
PKB/Akt
RAC-PK-alpha
protein kinase Akt
PKB/Akts
RAC-alpha serine/threonine kinase
Akt/PKB
protein kinase B-alpha
tumor rejection antigen peptide pRLib
protein kinase B alpha
RAC-ALPHA
thymoma viral proto-oncogene 1; thymoma viral proto-oncogene
thymoma viral proto-oncogene I
LOC217879
v-akt murine thymoma viral oncogene-like protein 1
OTTMUSP00000022944
serine/threonine protein kinase B
LOC268604
PKB alpha
v-akt murine thymoma viral oncogene homologue 1
v-akt murine thymoma viral oncogene homolog I
Murine thymoma viral (v-akt) oncogene homolog I
PRKBA
AKT1 kinase
thymoma viral proto-oncogene 1
Akt1
Protein kinase B
murine thymoma viral (v-akt) oncogene homolog 1
AKT serine/threonine kinase 1
MGC99656
OTTMUSP00000022949
Akt I
AKTI
PKB
proto-oncogene c-Akt
LTR-akt
proto-oncogene proteins c-akt
protooncogene protein c akt
AKT1m
RAC
PKB-ALPHA
serine-threonine protein kinase
RAC-alpha serine/threonine-protein kinase
PKBalpha
Akt1m protein
C6.1A
murine thymoma viral (v-akt) oncogene homolog-1
KRAC
serine/threonine protein kinase
KRAC_HUMAN
Akt1/PKB protein kinase
Protein kinase B
amelogenesis imperfecta 3, hypomaturation or hypoplastic type
AIH3
similar to thymoma viral proto-oncogene 1; thymoma viral proto-oncogene
LOC569086
chromosome
scaffold
similar to protein kinase N2
Ms6-1
minisatellite I
minisatellite-1 detected by probe 33
AKT1 protein
minisatellite-1
minisatellite-1 detected by probe 33.6
Ms6 I

EC Number 2.7.11.1
2.7.1.37
2.7.1.-

GO ID 0071889
0005524
0032794
0005516
0019899
0016301
0030235
0005547
0043325
0042803
0005080
0004672
0051721
0004674
0004712
0007186
0007249
0038061
0031295
0031929
0032148
0006924
0007568
0043276
0008637
0008643
0030154
0002042
0030030
0008283
0006464
0006974
0071276
0071364
0097011
0071456
0032869
0071260
1990090
0071407
0140052
0071380
0034614
0071356
0035924
0051186
0019221
0031018
0007173
0072655
0060079
0097194
0007281
0042593
0006006
0005978
0060709
0030212
0006954
0008286
0048009
0035655
0035556
0060716
0031663
0072656
0060644
0001893
0046329
0045746
0043066
0010507
0045792
0043154
0010951
2001240
0031999
0010629
1903038
2000402
0016242
1901215
1902176
0010748
0032091
0051898
0006469
0100002
0071901
0031397
0045861
0090201
0006809
0001649
0018105
0018107
0032287
0014065
0016310
0051091
1900087
1903721
0043065
0043536
0030307
0008284
0032270
0045737
0032079
0001938
0045742
0045600
0010763
0010628
0046326
0010907
0045725
0046889
0010918
0045429
0051000
0046622
0033138
0032436
2000010
1900182
1903078
0001934
0048661
0010765
0045944
0045893
0045907
0046777
0030163
0006606
0043491
0006468
0016567
0042981
0030334
0005979
0043488
0031641
0010975
0050999
1901796
0006417
0070141
0034405
0032094
0060416
0009408
1990418
0006979
0007165
0021510
0051146
0006412
0005911
0036064
0005737
0005829
0015630
0005739
0005654
0005634
0005886
0098794
0032991
0005819
0031982
0000166
0019901
0016740
0006915
0005975
0036294
0071363
1901653
0007010
0005977
0007275
0007399
0032880
0009725
0010033
0016020
2001047
1901976
0044281
0014066
0038128
0005543
0010467
0099565
0030168
0016772
0042802
0005622
0030027
0045087
0045768
0045884
0016071
0016070
0000060
0005515
0038095
0043234
0006810
0048010
0048011
0048015
0007596
0097193
0006916
0015758
0008543
0031659
1900740
0008633
0090004
0046209
0061024
0042640
0008629
0030155
0005625
0004713
0005351
0001568
0007242
0001890
0040018
0070201
0005856
0006445
0000074
0050875
0004702
0008151
0007048
0023034
0001764
0010165
0000151
0030234
2001243

KEGG ID hsa:207
mmu:11651
rno:24185

MedLine Reference 10400692
11572795
11809761
11834296
11904450
12084817
12089143
12095990
12112022
12140289
12145204
12194869
12198247
12392981
12496370
12543452
12586553
12624428
12734207
12761242
12767043
12789537
12810818
12816542
12816756
12818177
12829832
12837666
12900409
13129932
14517300
14522978
14523027
14565960
14576824
14581516
14596918
14607273
14670845
14698990
14707121
14753441
15007074
15024023
15060019
15065872
15120593
15149850
15203192
15282275
15289442
15319368
15337841
15375154
15451022
15466647
15489316
15496504
15501455
15511630
15574336
15590660
15616009
15632127
15637121
15694367
15706595
15780591
15797868
15809304
15814837
15845076
15848222
15853465
15856020
15890358
15890643
15896702
15896972
15979279
16027121
16027165
16046294
16049005
16061478
16087293
16098714
16123202
16171808
16181409
16237183
16269516
16282323
16316997
16337154
16343426
16428351
16440211
16452480
16466740
16531507
16532026
16540465
16567807
16596723
16642037
16679308
16717100
16719794
16794215
16843447
16855220
16864652
16949134
16956580
16966378
16978869
17109063
17142780
7999118
9632753
10349636
10428027
10485701
10521450
10579998
10802656
10811865
10922068
11042159
11076861
11086988
11217851
11238953
11282895
11376107
11533044
11544177
11549290
11590437
11731234
11752635
11777951
11861503
11909972
11943770
11950275
11956204
11997518
12015964
12031847
12032842
12042314
12052887
12084724
12091320
12097372
12124386
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12134068
12140361
12146978
12150915
12162464
12163490
12217896
12237475
12244155
12270033
12388598
12419217
12446787
12466851
12477932
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12524439
12525499
12529330
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12705474
12717433
12718435
12761849
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12782295
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12783884
12791994
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12837294
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12865424
12869584
12884297
12890675
12904304
12938156
12944477
12944902
14502571
14522959
14522993
14559920
14560023
14561707
14595115
14597666
14610089
14623889
14633850
14656892
14657000
14691534
14701865
14730361
14744754
14744864
14747529
14749368
14749824
14755341
14966566
14967838
14985363
14985505
14988230
15010863
15020298
15046607
15081586
15100285
15100319
15105289
15107468
15121188
15128676
15166036
15169915
15192111
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15199124
15207235
15217935
15226309
15241468
15247222
15254091
15278907
15280422
15309026
15322182
15345655
15351728
15361852
15364809
15381256
15389876
15448167
15456827
15459205
15467831
15485887
15489897
15509711
15527798
15528226
15537637
15546863
15572359
15572689
15578100
15579468
15580267
15582777
15583002
15611473
15663476
15678105
15695173
15705789
15713628
15713641
15723049
15753085
15757972
15761494
15764603
15769848
15775979
15782199
15797869
15799971
15817464
15833736
15836427
15840586
15842198
15887120
15946254
15967113
15994435
16000198
16005454
16007268
16036916
16036919
16049178
16075056
16083985
16116448
16135819
16141072
16141073
16141217
16151855
16169459
16179343
16203862
16204028
16207820
16227992
16239343
16263172
16287854
16293788
16298682
16310342
16338928
16352665
16354698
16357133
16375864
16453020
16453021
16478789
16478996
16484540
16487036
16495456
16510873
16511503
16513830
16516160
16537363
16581799
16613850
16613861
16626396
16645141
16680151
16682621
16687609
16704410
16707461
16741926
16763066
16778075
16787946
16797529
16798838
16840722
16880210
16882732
16882883
16886062
16889755
16904613
16914513
16916926
16917099
16923802
16923958
16950125
16950770
16963136
16966610
16973750
16982699
17012749
17015449
17015619
17019809
17043309
17045205
17052453
17068339
17077150
17124499
17141631
17202487
1794043
7585504
8437858
8889548
9415393
9620559
10082674
10085094
10102273
10217147
10224060
10226025
10358014
10376602
10376603
10438924
10454575
10485710
10485711
10490823
10491192
10497255
10527852
10542266
10570282
10576742
10617634
10635328
10698680
10748004
10833263
10866658
10869359
10872470
10896934
10910062
10926925
10930578
10958679
10983986
10995457
11035810
11042204
11116148
11139588
11154276
11154281
11156376
11156964
11274386
11278835
11313479
11404460
11410590
11410591
11438723
11445557
11504915
11535620
11546794
11579209
11583630
11585925
11598301
11689711
11696579
11707444
11707464
11710897
11756412
11777913
11782427
11809791
11825911
11828257
11855836
11877387
11884598
11902142
11903042
11923280
11956222
11960368
11976320
11994271
11994280
12009899
12011046
12062056
12062094
12070137
12077256
12138087
12138205
12149249
12167664
12167717
12176337
12176338
12176997
12218048
12244301
12244302
12244303
12297295
12376533
12393747
12438239
12446767
12458207
12527373
12529294
12535517
12592338
12621049
12637511
12687010
12722480
12727836
12734380
12741986
12757707
12768030
12783873
12808093
12853467
12874217
12888921
12919677
12952968
12972603
14500673
14520710
14523021
14534536
14566704
14568991
14611643
14612949
14625285
14636889
14645242
14647146
14679206
14702039
14713953
14742298
14749367
14755253
14973226
14985374
15001646
15010337
15016818
15026145
15047604
15047866
15060171
15067058
15102693
15115729
15136501
15146197
15156201
15187088
15187138
15194442
15203190
15242771
15262962
15262978
15263908
15271644
15283964
15284024
15316080
15326564
15331441
1533586
15342781
15385469
15388791
15389633
15465021
15467757
15475446
15522255
15525681
15533996
15539407
15545271
15545519
15574337
15581622
15607733
15609321
15665327
15665818
15668028
15710591
15718470
15722337
15743789
15778376
15784622
15802268
15806160
15817639
15831676
15837948
15845651
15861136
15879168
15888491
15896313
15905178
15911620
15922745
15961723
15987444
15993382
15994200
15998799
16007163
16007172
16007182
16012720
16026766
16027169
16049004
16049961
16055703
16091017
16099944
16114056
16115861
16128748
16139227
16142341
16148125
16160160
16163388
16174774
16177823
16202996
16216590
16224021
16243840
16263580
16274701
16278380
16280327
16293694
16338927
16365168
16373405
16405925
16407258
16407271
16412424
16428439
16434970
16466644
16474850
16478297
16508008
16532036
16537497
16543232
16549426
16551632
16564100
16568092
16571745
16583435
16601838
16616456
16644866
16651639
16670089
16682946
16684529
16723503
16732486
16763222
16774943
16775835
16785234
16790501
16790529
16820098
16822839
16839745
16840713
16844778
16849522
16897758
16926151
16932738
16962653
16972255
16977260
16981720
16987028
16987250
16988010
16990258
17008323
17015676
17041888
17060455
17141917
1718748
1851997
3037531
3384441
7774014
7891724
8524413
8978681
9005852
9019819
9368760
9381178
9394803
9395488
9736715
9812896
9829964
9973250
11508278
14761976
15118108
15489334
16820947
16842970
16862180
16916907
16946008
17006756
17016437
17024099
17043653
17050554
17065200
17081983
17088265
17097759
17098228
17099727
17113264
17128418
17136479
17136481
17143278
17148458
17151107
17169805
17173971
17179152
17214972
17215852
17235455
17244606
17276404
17287851
17299206
17307335
17310852
17317726
17317825
17318262
17333095
17335965
17342093
17351066
17375124
17383860
17386267
17400190
17404186
17428466
17443665
17458890
17461449
17462862
17469127
17470458
17478078
17483438
17493174
17495954
17495959
17504381
17507655
17507800
17513297
17513702
17520698
17522055
17544405
17544543
17549359
17553806
17565979
17569669
17584963
17606718
17611497
17612563
17616681
17616684
17616691
17638918
17725107
9512493
15249583
15678128
16286931
16514068
16537919
16636172
16889766
16962829
17021050
17081778
17082189
17181553
17209049
17215071
17220321
17251350
17287359
17290308
17311300
17322282
17322895
17332061
17332510
17369192
17382199
17394208
17396120
17397400
17407381
17412896
17417601
17428826
17434462
17439945
17446044
17460049
17464994
17485440
17486091
17490611
17517888
17521884
17531194
17537803
17562714
17609365
16820027
16944316
17016676
17203219
17272355
17272774
17317782
17371807
17496209
17545147
17555943
17628541
17629454
17632284
12244133
14588144
15501927
15808505
16172287
16816403
16963022

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio
Human

Mouse chromosome position 12 61.2 cM
12 57.0 cM

OMIM ID 164730
114500
615109
114480
167000
176920
181500
604370
OMIM:164730
OMIM:181500
OMIM:301201

Rat chromosome position 6q32

Hugo ID 391
HGNC:391

Human chromosome position 14q32.33
14q32.32

Swiss-Prot Accession B0LPE5
P31749
B3KVH4
P31749.2
P31750
P31750.2
P47196
P47196.1
B2RAM5
B7Z5R1
Q9BWB6
Q62274
Q6GSA6
Q9BV07
Q8BS26
Q6GSA6_MOUSE
AKT1_HUMAN
AKT1_RAT
B0LPE5_HUMAN
B3KVH4_HUMAN
Q6ZMW5

PIR ID A39360
S33364
JC2437

GenBank ID NC_000014
XR_002957536
NM_001014431
NP_001014431
NM_001014432
NP_001014432
NM_005163
NP_005154
NG_012188
A62733
CAA03677
A63232
CAA03712
AH011307
AL583722
AL590327
CH471061
EAW81881
EAW81882
EAW81883
EU332835
ABY87524
JC006886
CDL93491
JC604553
CEF39425
JC604555
CEF39426
JC604557
CEF39427
JC739425
CEF39431
JX512440
AGC09587
KT583844
KT585272
KU639689
AMR60723
KU639690
AMR60724
KU639691
AMR60725
KU639692
AMR60726
KU639693
AMR60727
KU639694
AMR60728
KU639695
AMR60729
KU639696
AMR60730
KU639697
AMR60731
KU639698
AMR60732
KU639699
AMR60733
KU639700
AMR60734
KU639701
AMR60735
KU639702
AMR60736
KU639703
AMR60737
KU639704
AMR60738
KU639705
AMR60739
LN845722
LN845723
LN845724
LN845725
LN845726
LN845727
LN845728
LN845729
LN845730
LN845731
LN845732
LN845733
LN845734
LN845735
LN845736
LN845737
LN845738
LN845739
LN845740
LN845741
LN845742
LN845743
LN845744
LN845745
LN845746
LN845747
AB451242
BAG70056
AB451367
BAG70181
AK094287
AK122894
BAG53786
AK131465
AK299310
BAH12997
AK314256
BAG36922
BC000479
AAH00479
BC001737
AAH01737
BC063408
BC084538
AAH84538
BX647722
BX648205
CN414251
KF836747
AHA61679
KF836748
AHA61680
KF836749
AHA61681
KF836750
AHA61682
KU177898
ALQ33356
KU177899
ALQ33357
M63167
AAA36539
X61037
CAA43372
P31749
NC_000078
NM_001165894
NP_001159366
NM_009652
NP_033782
XM_006515416
XP_006515479
XM_006515415
XP_006515478
NM_001331107
AC124373
AF534134
AAN04036
CH466549
EDL18586
EDL18587
JC006884
CDL93490
AI843381
AK040758
BAC30695
AK154936
BAE32937
AK196375
AK211494
AK214116
AK216454
BC066018
AAH66018
BC115583
AAI15584
KF836746
AHA61678
M94335
AAA18254
S79788
AAB35511
X65687
CAA46620
P31750
NC_005105
XM_006240631
XP_006240693
XM_008764918
XP_008763140
NM_033230
NP_150233
AC_000074
AAHX01046747
AC141959
CH474034
EDL97422
D30040
BAA06279
P47196
EU832571
AC_000146
AC_000034
AF283830
XP_005267458
XP_005267459
NC_018925
ABBA01002984
ABBA01002985
ABBA01002983
AF283820
AF283821
AF283822
AF283823
AF283824
AF283825
AF283826
AF283827
AF283828
AF283829
ACE87663
AABR06046383
AAL55732
AABR06046382
XP_006515480
XP_011534846
XP_011534845
AF283818
AF283819
XM_006515417
EU832491
XM_005267401
XM_005267402
ACE86973
XM_011536543
XM_011536544
AMYH02029951
AMYH02029952
AAHY01103682
AAHY01103681
NT_026437
NW_001838116
NW_925561
AC_000057
AK127193
BAG54449
CR611982
Q9BV07
NT_166318
NW_001030504
Q6GSA6
Q8BS26
NW_047762
NW_001084847
BAD18610
Q6ZMW5
BG064484
BG077899
NW_000055
NT_039551
BE952690
1346401
485403
200642
22653384
26333955
287807
400144
41946110
74191998
81874935
81910973
119602287
119602288
119602289
12653417
12804627
18027298
190828
35481
3716606
3717081
47077445
54038761
60391226
74710591
74724882
133777895
148686639
148686640
149044040
NT_086807
110825704
58373279
631
AAW71957
AY781100
CAA43371
NC_007319
NM_173986
NP_776411
NW_001494072
Q01314
X61036
NC_007116
NW_001513403
XM_692450
XP_697542
NT_039553
XM_192740
XP_192740
125816306
126007510
569086
Dr.35935
dre:569086
51493278
BAC30169
BC048179
AK028483
6753033
6753034
AK079866
190827
26333954
AK149844
BC021313
AAH48179
35480
P46737
400143
200641
33875493
BAB27894
AA588967
AAB29006
NT_039706
51829386
12804626
3716605
34367364
3717080
287806
NP_666068
NM_145956
BAE29117
AK164578
NC_000086
34528338
22653383
4885061
4885060
18027297
34935858
15100164
AK030736
15100163
S68022
AAH21313
AK038919
485402
54038760
AK011876
51472322
41946109
NT_039753
BAC27105
NP_001318036
NP_001369359
NP_001369360
NP_001369361
NP_001369362
NM_001382433
NM_001382430
NM_001382432
NM_001382431

Swiss-Prot ID AKT1_HUMAN
AKT1_MOUSE
AKT1_RAT
Q6GSA6_MOUSE
B3KVH4_HUMAN
B0LPE5_HUMAN

Cell Localization Cytoplasm
Nucleus
Cell membrane

Ensembl ID ENSG00000142208
ENSP00000384293.2
ENST00000407796.6
ENSP00000270202.4
ENST00000349310.7
ENSP00000450688.1
ENST00000555528.5
ENSMUSG00000001729
ENSMUSP00000001780.3
ENSMUST00000001780.9
ENSMUSP00000122222.2
ENSMUST00000128300.8
ENSRNOG00000028629
ENSRNOP00000038369.2
ENSRNOT00000031164.3
ENST00000554848
ENSMUST00000128300
ENST00000407796
ENSMUST00000001780
ENSP00000451166
ENST00000349310
ENSMUSP00000001780
ENSP00000450688
ENSRNOT00000031164
ENSP00000384293
ENSMUSP00000122222
ENSP00000270202
ENSRNOP00000038369
ENST00000555528

MGI ID MGI:87986
87986
97157

RGD ID 2081

Unigene ID Rn.11422
Hs.525622
Mm.6645
Bt.4843
Dr.35935
Hs.368861
Hs.71816

Homologene ID 3785
207
11651
24185

Shape Sickle-vertex

IPI ID IPI00212844
IPI00323969
IPI00012866
IPI00556735

Chromosome position X A7.3
12 57.0 cM
14q32.32
6q32

Microarray ID 100970_at
1368862_at
1375178_at
D30040_at
A_43_P12733
NM_033230
1416657_at
1425711_a_at
x65687_s_at
Msa.237.0_at
A_65_P03244
M94335.1
A_65_P20672
H3020C06-3
A_51_P237553
NM_009652
M63167
67939_at
1564_at
207163_s_at
81268_at
M63167_at
rc_aa011575_f_at
rc_aa041305_f_at
rc_aa044077_f_at
rc_aa056416_f_at
rc_aa063612_f_at
rc_t03388_f_at
A_23_P14358
I_959380
A_14_P108902
A_14_P105663
A_14_P138231
A_23_P2960
R083
OH8088
C296
OR0248
M640

Homo sapiens Chromosome position 14q32.32

Ensembl Transcript ID ENST00000402615
ENST00000407796
ENST00000349310

ENSEMBL ENSG00000142208

FunctionalClass identical protein binding
protein binding
protein kinase
protein serine/threonine kinase
protein-tyrosine kinase
receptor signaling protein serine/threonine kinase
ATP binding
kinase
nucleotide binding
sugar porter
transferase
sugar:hydrogen ion symporter
protein self binding
enzyme regulator

Hugo Symbol AKT1

Bos taurus Chromosome position 21

Mus musculus Chromosome position 12 57.0 cM

KEGG pathway Insulin signaling pathway
B cell receptor signaling pathway
Apoptosis
Jak-STAT signaling pathway
Focal adhesion
Tight junction
Toll-like receptor signaling pathway
MAPK signaling pathway
T cell receptor signaling pathway
Adipocytokine signaling pathway
Chronic myeloid leukemia
Colorectal cancer
Fc epsilon RI signaling pathway
Glioma
Melanoma
Pancreatic cancer
VEGF signaling pathway
mTOR signaling pathway
Endometrial cancer
ErbB signaling pathway
Non-small cell lung cancer
Prostate cancer
Renal cell carcinoma
Small cell lung cancer

ProteinAtlas SubcellularLocation Main location: Nucleus; Other location: Cytoskeleton (Microtubules); Expression type: Staining; Reliability: Supportive

State p

Rattus norvegicus Chromosome position 6q32

Ensembl Gene ID ENSG00000142208

Keyword protein serine/threonine kinase
plasma membrane
map kinase
docking protein
cyclin
5.4.2.-
ph domain
nucleus
map kinases
protein serine/threonine kinase activity
gtpase
cytosol
cytoplasm
MEK
protein tyrosine kinase
small monomeric GTPase

ProteinAtlas NormalTissue Tissue: gall bladder; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: hippocampus; Cell type: neuronal cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: bile duct cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: epididymis; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: tonsil; Cell type: germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: vagina; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: lymph node; Cell type: germinal center cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: adrenal gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: uterus
pre-menopause; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: placenta; Cell type: decidual cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: liver; Cell type: hepatocytes; Level: Low; Expression type: APE; Reliability: High
Tissue: adrenal gland; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: appendix; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: appendix; Cell type: lymphoid tissue; Level: High; Expression type: APE; Reliability: High
Tissue: bone marrow; Cell type: hematopoietic cells; Level: High; Expression type: APE; Reliability: High
Tissue: breast; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: High; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: cells in granular layer; Level: High; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: cells in molecular layer; Level: High; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: Purkinje cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: cerebral cortex; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: cervix, uterine; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: colon; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: duodenum; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: epididymis; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: fallopian tube; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: gall bladder; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: heart muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: High
Tissue: hippocampus; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: hippocampus; Cell type: neuronal cells; Level: High; Expression type: APE; Reliability: High
Tissue: kidney; Cell type: cells in glomeruli; Level: Medium; Expression type: APE; Reliability: High
Tissue: kidney; Cell type: cells in tubules; Level: Medium; Expression type: APE; Reliability: High
Tissue: lateral ventricle; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: liver; Cell type: bile duct cells; Level: High; Expression type: APE; Reliability: High
Tissue: lung; Cell type: macrophages; Level: Medium; Expression type: APE; Reliability: High
Tissue: lung; Cell type: pneumocytes; Level: High; Expression type: APE; Reliability: High
Tissue: lymph node; Cell type: germinal center cells; Level: High; Expression type: APE; Reliability: High
Tissue: lymph node; Cell type: non-germinal center cells; Level: High; Expression type: APE; Reliability: High
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: High; Expression type: APE; Reliability: High
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: ovary; Cell type: follicle cells; Level: High; Expression type: APE; Reliability: High
Tissue: ovary; Cell type: ovarian stroma cells; Level: High; Expression type: APE; Reliability: High
Tissue: pancreas; Cell type: exocrine glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: pancreas; Cell type: islets of Langerhans; Level: High; Expression type: APE; Reliability: High
Tissue: parathyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: placenta; Cell type: decidual cells; Level: High; Expression type: APE; Reliability: High
Tissue: placenta; Cell type: trophoblastic cells; Level: High; Expression type: APE; Reliability: High
Tissue: prostate; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: rectum; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: salivary gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: seminal vesicle; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: skeletal muscle; Cell type: myocytes; Level: Low; Expression type: APE; Reliability: High
Tissue: skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: small intestine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: spleen; Cell type: cells in red pulp; Level: Medium; Expression type: APE; Reliability: High
Tissue: spleen; Cell type: cells in white pulp; Level: Medium; Expression type: APE; Reliability: High
Tissue: stomach, lower; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: stomach, upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: testis; Cell type: cells in seminiferus ducts; Level: High; Expression type: APE; Reliability: High
Tissue: testis; Cell type: Leydig cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: thyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: germinal center cells; Level: High; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: non-germinal center cells; Level: High; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: urinary bladder; Cell type: urothelial cells; Level: High; Expression type: APE; Reliability: High
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: High; Expression type: APE; Reliability: High
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: High; Expression type: APE; Reliability: High
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: vagina; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: High

LocatorString gscquery:curcumin+prostate+cancer
pmquery:curcumin+prostate+cancer
pmquery:curcumin prostate cancer
pmquery:egfr+transactivation

EnzymeConsortium 2.7.1.37