URN | urn:agi-llid:864 |
---|---|
Total Entities | 0 |
Connectivity | 1826 |
Name | RUNX3 |
Description | runt related transcription factor 3 |
Notes | This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
Primary Cell Localization | Nucleus |
Class | Transcription factor |
Pathway | Proteins Involved in Melanoma |
---|---|
T-Cells Differentiation Block in Psoriasis | |
Th1-Cell Activation in Crohn's Disease | |
Proteins Involved in Hepatocellular Carcinoma | |
Hepatocellular Carcinoma | |
Growth Factor Signaling in Hepatocellular Carcinoma | |
Proteins Involved in Psoriatic Arthritis | |
Proteins Involved in Neuroblastoma | |
Proteins Involved in Endometriosis | |
Prostate Cancer | |
EZH2 Methyltransferase Role in Cancer | |
NOTCH -> Expression Targets in Thymus | |
PPAR Psoriasis | |
1_Differentiation of psoriatic T cells | |
4_1_Polymorphisms associated with inflammatory bowel diseases | |
New Pathway | |
Differentiation of psoriatic T cells |
Group | Genes Hypermethylated in Melanoma |
---|---|
Genes with Mutations Associated with Hepatocellular Carcinoma | |
Genes Hypermethylated in Glioma |
MedScan ID | 864 |
---|
LocusLink ID | 864 |
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12399 | |
156726 |
Alias | runt domain, alpha subunit 3 |
---|---|
FLJ34510 | |
core binding factor alpha 3 | |
acute myeloid leukemia-2 | |
Runt related transcription factor 3 | |
CBFA3 | |
runt-related transcription factor III | |
RP23-167O21.1 | |
core-binding factor subunit alpha-3 | |
acute myeloid leukemia 2 protein | |
transcription factor CBFA3 | |
core binding factor alpha 3 subunit | |
RP3-398I9.1 | |
RUNX3 | |
AML2 | |
polyomavirus enhancer-binding protein 2 alpha C subunit | |
transcription factor RUNX3 | |
core-binding factor, runt domain, alpha subunit III | |
CBF-alpha-3 | |
MGC16070 | |
acute myeloid leukemia 2 | |
SL3/AKV core-binding factor alpha C subunit | |
OTTHUMP00000003370 | |
runt domain, alpha subunit III | |
transcription factor AML2/CBFA3 | |
SL3-3 enhancer factor 1 alpha C subunit | |
PEBP2aC | |
acute myeloid leukemia gene-2 | |
oncogene AML-2 | |
OTTHUMP00000003371 | |
core-binding factor, runt domain, alpha subunit 3 | |
OTTMUSP00000042121 | |
acute myeloid leukemia gene 2 | |
PEA2 alpha C | |
PEBP2A3 | |
transcription factor AML2 | |
pebp2 alpha c | |
RUNX family transcription factor 3 | |
runt-related transcription factor 3 | |
PEA2-alpha C | |
PEBP2-alpha C | |
acute myeloid leukaemia gene 2 |
GO ID | 0005524 |
---|---|
0003700 | |
0000981 | |
0000977 | |
0002062 | |
0030097 | |
0043371 | |
0045786 | |
0050680 | |
0000122 | |
0030182 | |
0048935 | |
0043378 | |
0045893 | |
0006468 | |
0006355 | |
0071559 | |
0006366 | |
0016513 | |
0005737 | |
0005829 | |
0043231 | |
0000790 | |
0005730 | |
0005654 | |
0005634 | |
0003677 | |
0046332 | |
0042826 | |
0007411 | |
0048469 | |
0031069 | |
0032609 | |
0042789 | |
0031175 | |
2001238 | |
0045944 | |
0006357 | |
0001503 | |
0006351 | |
0045595 | |
0005794 |
KEGG ID | hsa:864 |
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Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Mus musculus | |
Homo sapiens | |
Rattus norvegicus |
Mouse chromosome position | 4 67.19 cM |
---|
OMIM ID | 600210 |
---|
Rat chromosome position | 5q36 |
---|
Hugo ID | 10473 |
---|---|
HGNC:10473 |
Human chromosome position | 1p36.11 |
---|---|
1p36 |
Swiss-Prot Accession | A0A024RAH4 |
---|---|
Q13761 | |
Q13761.2 | |
Q3U1Q3 | |
Q64131.3 | |
Q91ZK1 | |
B1AJV5 | |
Q12969 | |
Q13760 | |
Q64131 |
PIR ID | B55563 |
---|---|
S60078 |
Swiss-Prot ID | RUNX3_HUMAN |
---|
Cell Localization | Nucleus |
---|---|
Cytoplasm |
Ensembl ID | ENSG00000020633 |
---|---|
ENSP00000382800.1 | |
ENST00000399916.5 | |
ENSP00000343477.3 | |
ENST00000338888.3 | |
ENSP00000308051.6 | |
ENST00000308873.10 | |
ENSMUSG00000070691 | |
ENSMUSP00000050353.7 | |
ENSMUST00000056977.13 | |
ENSRNOG00000054217 | |
ENSRNOP00000075140.1 | |
ENSRNOT00000086650.1 | |
ENSP00000382800 | |
ENST00000399916 | |
ENSP00000308051 | |
ENST00000308873 | |
ENSMUSP00000050353 | |
ENSMUST00000056977 | |
ENSRNOP00000075140 | |
ENSRNOT00000086650 | |
ENSRNOG00000018058 | |
ENSRNOP00000045395 | |
ENSRNOT00000041474 |
MGI ID | MGI:102672 |
---|
RGD ID | 620082 |
---|
Unigene ID | Hs.170019 |
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Mm.378894 | |
Rn.34220 |
Homologene ID | 37914 |
---|
Shape | O-vertex |
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