Protein APLN

URN urn:agi-llid:8862
Total Entities 3
Connectivity 2082
Name APLN
Description apelin
Notes This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]
Primary Cell Localization Extracellular
Class Ligand

ChildConcepts apelin-36
apelin-17
apelin-13

Pathway Adipokines Production by Adipocyte
Proteins Involved in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Proteins Involved in Polycystic Ovary Syndrome
Proteins Involved in Epilepsy
Proteins Involved in Amyotrophic Lateral Sclerosis
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
Model of PPARG signaling in psoriasis
drug-target moltransport

Group Genes with Mutations Associated with Obesity

MedScan ID 8862

LocusLink ID 8862
30878
58812

Alias peptide ligand for APJ receptor
peptide ligand for APJ receptors
AGTRL1 ligand
RP23-455F14.1
6030430G11
APLN
6030430G11Rik
APJ endogenous ligand
UNQ471
apelin, peptide ligand for APJ receptor
apelin, AGTRL1 ligand
apelin, peptide ligand for APJ receptors
Apel
apelin
OTTMUSP00000019097
RIKEN cDNA 6030430G11 gene
preproapelin
XNPEP2

GO ID 0031704
0005179
0042803
0005102
0007186
0001525
0060183
0060976
0042756
0007369
0006955
0007595
0045776
0040037
0010629
1904706
0045906
1904022
0051461
0051466
0045823
0031652
0042327
1902895
1905564
0043576
0002026
0007165
0005576
0005615
0048471
0007631
0007275
0097755
0008284
0050878
0010469

KEGG ID hsa:8862
mmu:30878
rno:58812

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position X

OMIM ID 300297

Rat chromosome position Xq36

Hugo ID 16665

Human chromosome position Xq26.1

Swiss-Prot Accession Q9ULZ1
Q9ULZ1.1
Q544B5
Q9R0R4
Q9R0R4.1
Q9R0R3
Q9R0R3.1
Q4VY08
Q8WU89

GenBank ID NC_000023
NM_017413
NP_059109
NG_016718
AF179680
AAF25815
AL022162
CH471107
EAX11828
EAX11829
DQ385612
AB023493
BAA84975
AF086248
AK001855
AK312061
BAG34997
AY358657
AAQ89020
BC021104
AAH21104
BM992527
DB481574
Q9ULZ1
NC_000086
NM_013912
NP_038940
AL672274
AL714010
CH466570
EDL29063
AB023494
BAA84976
AJ290423
CAC83678
AK020057
AK042076
BAC31156
BB618863
BC020015
AAH20015
DQ832282
ABI30216
Q9R0R4
NC_005120
NM_031612
NP_113800
AC_000089
AAHX01114444
AC127934
CH473991
EDM10904
AB023495
BAA84977
AF179679
AAF25814
BC080843
AAH80843
Q9R0R3

Swiss-Prot ID APEL_HUMAN
APEL_MOUSE
APEL_RAT

Cell Localization Secreted
Extracellular space

Ensembl ID ENSG00000171388
ENSP00000391800.2
ENST00000429967.3
ENSMUSG00000037010
ENSMUSP00000046012.7
ENSMUST00000039026.7
ENSRNOG00000003984
ENSRNOP00000005331.3
ENSRNOT00000005331.5

MGI ID MGI:1353624

RGD ID 620672