Protein MMP1

URN urn:agi-llid:4312
Total Entities 0
Connectivity 7276
Name MMP1
Description matrix metallopeptidase 1
Notes This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Primary Cell Localization Extracellular

Pathway Osteoarthritis
Skin Aging
Plasmin Effects in Inflammation
Bradykinin Effects in Inflammation
Nociception Expression Targets Signaling
CCR1 Expression Targets
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Arterial Hypertension
Myocardial Remodeling
Myocardial Infarction
Proteins with Altered Expression in Melanoma
Melanoma
Proteins Involved in Melanoma
IL17 Signaling in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
TGF-beta Signaling in Skin Aging
Proteins Involved in Photoaging
Extracellular Matrix Degradation in Skin Aging
Proteins Involved in Colorectal Neoplasms
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Proteins Involved in Osteoarthritis
Proteins Involved in Polycystic Ovary Syndrome
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Systemic Scleroderma
Skin Fibrosis
Cathepsins Role in Periodontitis
Proteins Involved in Periodontitis
Proteins Involved in Astrocytoma
Glioma Invasion Signaling
Proteins Involved in Glioma
Proteins Involved in Adhesion, Migration and Invasion of Endometriotic Cell
Proteins Involved in Endometriosis
Proteins with Altered Expression in Endometriosis
Proteins Involved in Age-Related Macular Degeneration
PGF2-alpha Effect on Treatment
Proteins Involved in Chronic Obstructive Pulmonary Disease
Alveolar Epithelial Cell Dysfunction in COPD
Noradrenaline/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Elevated Receptors -> Expression Targets in Heart
CXCL12 Expression Targets
CCL3 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> STAT Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> STAT Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
EGFR Transactivation in Cancer and Non-Cancer Cells
Proteins with Altered Expression in Cancer Metastases
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
IGF1 -> CEBPA/FOXO1A Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
IL6 Expression Targets
IL10 Expression Targets
IL22 Expression Targets
IL11 Expression Targets
Prostaglandin F Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
PGE1 Expression Targets
CD40 -> Expression Targets in Thymus
Elevated Receptors -> Expression Targets in Muscle
OSM/OSMR Expression Targets
PDGFD -> AP-1 Expression Targets
PDGFD -> STAT Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
OXT Expression Targets
POMC Expression Targets
EDN1 Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PAF Expression Targets
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB2-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-ACVRL1 Expression Targets
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
CD40LG -> STAT Expression Targets
TNF -> STAT Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
IL1B -> NO Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
PLAU -> STAT1 Expression Targets
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> STAT Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
WNT5A Expression Targets
ace2
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival time
Neighbors of functional recovery
Neighbors of cancer survival
Neighbors of clinical stage
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of treatment outcome
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of morbidity
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of shear stress
Neighbors of blood pressure
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of body mass index
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of ejection fraction
Neighbors of vascular tone
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of pathological response
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival time
Neighbors of functional recovery
Neighbors of cancer survival
Neighbors of clinical stage
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of treatment outcome
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of morbidity
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of shear stress
Neighbors of blood pressure
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of body mass index
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of ejection fraction
Neighbors of vascular tone
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of pathological response
Neighbors of immune response
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of cell formation
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of tissue repair
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of lipid storage
Neighbors of pregnancy
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of leukocyte migration
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of lung development
Neighbors of autophagy
Neighbors of transcription activation
Neighbors of senescence
Neighbors of hepatocyte proliferation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of cancer cell growth
Neighbors of hemato-encephalic barrier
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of stem cell migration
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of infection
Neighbors of vascular injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of sepsis
Neighbors of death
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of heart disease
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of melanoma
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of heart failure
Neighbors of pulmonary fibrosis
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of myocardial fibrosis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of inflammatory cell
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of lung fibroblast
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of granulocyte
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of aortic smooth muscle cell
Neighbors of mammary epithelial cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of M2 macrophage
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of lung
Neighbors of liver
Neighbors of skin
Neighbors of lymph node
Neighbors of airway
Neighbors of aorta
Neighbors of bone
Neighbors of carotid artery
Neighbors of synovial membrane
Neighbors of esophagus
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of stomach
Neighbors of pancreas
Neighbors of lymphatic system
Neighbors of colorectal region
Neighbors of allantois
Neighbors of uterine cervix
Neighbors of nose
Neighbors of eye
Neighbors of cornea
Neighbors of periodontal ligament
Neighbors of hip region
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of chorionic gonadotropin
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of TSH
Neighbors of endothelin
Neighbors of NOS
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of histone H3
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of immunoglobulin
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of relaxin
Neighbors of TLR1/2 heterodimer
Neighbors of FSH
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of neuropeptides
Neighbors of histone acetyltransferase
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
1_2_Feedback relations between coagulation and fibrinolysis
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 4312

LocusLink ID 4312
83995
300339

Alias collagenase-like A
Mmp I
matrix metalloproteinase 1a (interstitial collagenase)
Interstitial collagenase
mammalian collagenase
Mmp1a
Mcola
matrix metallopeptidase 1a
3.4.24.7
myocardial collagenase
vertebrate collagenases
Matrix metalloproteinase-1
matrix metalloproteinase 1 (interstitial collagenase)
matrix metalloproteinase-1a
matrix metallopeptidase 1a (interstitial collagenase)
LOC115169
matrix metalloprotease 1 (interstitial collagenase)
Fibroblast collagenase
Matrix metalloprotease-1
Matrix metalloproteinase I
matrix metallopeptidase 1
LOC116389
MM(01)
collagenase-like B
matrix metalloprotease 1a (interstitial collagenase)
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
Mcol-A
vertebrate collagenase
Matrix metalloprotease I
interstitial collagenase A
MM01_HUMAN
CLG
CLGN
matrix metalloprotease 1
matrix metalloproteinase 1
MMP-1a
MMP-1

EC Number 3.4.24.7

GO ID 0004175
0004222
0004252
0008270
0044267
0030574
0019221
0022617
0030198
0050900
0032461
0006508
0016032
0031012
0005576
0005615
0008237
0008233
0071312
0035690
0071498
0071347
0071283
0071222
0071407
0071375
0071356
0071305
0001553
0001554
0010763
0014911
0042493
0014854
0071680
0009612
0005737
0005509
0005578
0016787
0046872
0007596

KEGG ID hsa:4312
mmu:83995

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 9

OMIM ID 120353
606963
226600

Rat chromosome position 8q11

Hugo ID 7155
HGNC:7155

Human chromosome position 11q22.2
11q22.3

Swiss-Prot Accession B4DN15
P03956
Q53G95
P03956.3
Q9EPL5
Q9EPL5.1
B5DFD5
P81563.1
P08156
Q149J4

PIR ID A37308

GenBank ID NC_000011
NM_001145938
NP_001139410
NM_002421
NP_002412
NG_011740
AF007878
AF023338
AJ002550
AP000619
AY769434
AAV28732
CH471065
EAW67031
HF583680
CCQ43177
M16567
AAA52033
U78045
AAB36941
AK024818
AK098450
AK130687
AK223034
BAD96754
AK223035
BAD96755
AK223036
BAD96756
AK223056
BAD96776
AK223281
BAD97001
AK225495
AK297723
BAG60077
AK301340
BAG62888
BC013118
AAH13118
BC013875
AAH13875
BT006874
AAP35520
BT020147
AAV38949
DC385245
DQ399597
ABD92796
M13509
AAA35699
M15996
AAA35700
X05231
CAA28858
X54925
CAA38691
P03956
NC_000075
NM_032006
NP_114395
AC115689
CH467335
EDL00990
AJ278462
CAC18880
AK049552
BAC33807
BC117756
AAI17757
BQ558168
Q9EPL5
NC_005107
NM_001134530
NP_001128002
AC_000076
AABR07069019
AAHX01053076
BC169019
AAI69019
P81563
NC_018922
AMYH02025488
DQ890729
ABM81655
DQ893904
ABM84830
NW_001034521
AAHY01195788
AAHY01195789
AC_000143
ABBA01039931

Swiss-Prot ID MMP1_HUMAN
MMP1A_MOUSE

Cell Localization Secreted
Extracellular space
Extracellular matrix
Secreted, extracellular space, extracellular matrix

Ensembl ID ENSG00000196611
ENSP00000322788.6
ENST00000315274.7
ENSMUSG00000043089
ENSMUSP00000151193.1
ENSMUST00000217651.1
ENSRNOG00000032353
ENSRNOP00000012595.2
ENSRNOT00000012595.3
ENSP00000322788
ENST00000315274
ENSMUSP00000034492
ENSMUST00000034492
ENSRNOP00000012595
ENSRNOT00000012595

MGI ID MGI:1933846

RGD ID 1307917

Unigene ID Hs.83169
Mm.156952
Rn.79007

Homologene ID 20544