Protein RUNX3

URN urn:agi-llid:864
Total Entities 0
Connectivity 1826
Name RUNX3
Description runt related transcription factor 3
Notes This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway Proteins Involved in Melanoma
T-Cells Differentiation Block in Psoriasis
Th1-Cell Activation in Crohn's Disease
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Psoriatic Arthritis
Proteins Involved in Neuroblastoma
Proteins Involved in Endometriosis
Prostate Cancer
EZH2 Methyltransferase Role in Cancer
NOTCH -> Expression Targets in Thymus
PPAR Psoriasis
1_Differentiation of psoriatic T cells
4_1_Polymorphisms associated with inflammatory bowel diseases
New Pathway
Differentiation of psoriatic T cells

Group Genes Hypermethylated in Melanoma
Genes with Mutations Associated with Hepatocellular Carcinoma
Genes Hypermethylated in Glioma

MedScan ID 864

LocusLink ID 864
12399
156726

Alias runt domain, alpha subunit 3
FLJ34510
core binding factor alpha 3
acute myeloid leukemia-2
Runt related transcription factor 3
CBFA3
runt-related transcription factor III
RP23-167O21.1
core-binding factor subunit alpha-3
acute myeloid leukemia 2 protein
transcription factor CBFA3
core binding factor alpha 3 subunit
RP3-398I9.1
RUNX3
AML2
polyomavirus enhancer-binding protein 2 alpha C subunit
transcription factor RUNX3
core-binding factor, runt domain, alpha subunit III
CBF-alpha-3
MGC16070
acute myeloid leukemia 2
SL3/AKV core-binding factor alpha C subunit
OTTHUMP00000003370
runt domain, alpha subunit III
transcription factor AML2/CBFA3
SL3-3 enhancer factor 1 alpha C subunit
PEBP2aC
acute myeloid leukemia gene-2
oncogene AML-2
OTTHUMP00000003371
core-binding factor, runt domain, alpha subunit 3
OTTMUSP00000042121
acute myeloid leukemia gene 2
PEA2 alpha C
PEBP2A3
transcription factor AML2
pebp2 alpha c
RUNX family transcription factor 3
runt-related transcription factor 3
PEA2-alpha C
PEBP2-alpha C
acute myeloid leukaemia gene 2

GO ID 0005524
0003700
0000981
0000977
0002062
0030097
0043371
0045786
0050680
0000122
0030182
0048935
0043378
0045893
0006468
0006355
0071559
0006366
0016513
0005737
0005829
0043231
0000790
0005730
0005654
0005634
0003677
0046332
0042826
0007411
0048469
0031069
0032609
0042789
0031175
2001238
0045944
0006357
0001503
0006351
0045595
0005794

KEGG ID hsa:864

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 4 67.19 cM

OMIM ID 600210

Rat chromosome position 5q36

Hugo ID 10473
HGNC:10473

Human chromosome position 1p36.11
1p36

Swiss-Prot Accession A0A024RAH4
Q13761
Q13761.2
Q3U1Q3
Q64131.3
Q91ZK1
B1AJV5
Q12969
Q13760
Q64131

PIR ID B55563
S60078

GenBank ID NC_000001
NM_001320672
NP_001307601
NM_001031680
NP_001026850
NM_004350
NP_004341
XM_005246024
XP_005246081
XM_011542351
XP_011540653
AJ238394
CAB42882
AL023096
AL445471
CH471134
EAW95147
EAW95148
EAW95149
CQ834770
CAH05600
FB571463
CAR95149
FB571465
CAR95150
HI574042
CBX47510
HI574044
CBX47511
U14520
AAA86465
Z38104
Z38108
AF022726
AAB80759
AI375031
AJ001432
AK091829
AK300056
BAG61865
AK301044
BAG62657
AK310945
BC013362
AAH13362
DA935726
EF491807
EF491822
X79550
CAA56093
Z35278
CAA84541
Q13761
NC_000070
NM_019732
NP_062706
XM_006538506
XP_006538569
NT_187024
NM_001369050
AF169246
AAD46381
AF321443
AAK11181
AJ308681
CAC41361
AL731718
CH466552
EDL29993
CU459015
FJ026730
S78518
AAB34843
AF085246
AAC34127
AF155880
AAD38985
AK053910
BAC35587
AK155436
BAE33265
AK155802
BAE33440
AK185845
AK193548
AK196105
AK198691
AK200435
Q64131
NC_005104
NM_130425
NP_569109
AC_000073
AABR07050147
AABR07050148
AAHX01040222
AAHX01040223
CH473968
EDL80748
AF421886
AAL16092
FQ230848
NC_018912
AMYH02000534
AMYH02000535
XM_006537058
XP_006537121
AC_000026
AAHY01040740
AAHY01040741
BC168396
AAI68396
XM_006711016
XP_006711079
AC_000133
ABBA01059922
ABBA01059923

Swiss-Prot ID RUNX3_HUMAN

Cell Localization Nucleus
Cytoplasm

Ensembl ID ENSG00000020633
ENSP00000382800.1
ENST00000399916.5
ENSP00000343477.3
ENST00000338888.3
ENSP00000308051.6
ENST00000308873.10
ENSMUSG00000070691
ENSMUSP00000050353.7
ENSMUST00000056977.13
ENSRNOG00000054217
ENSRNOP00000075140.1
ENSRNOT00000086650.1
ENSP00000382800
ENST00000399916
ENSP00000308051
ENST00000308873
ENSMUSP00000050353
ENSMUST00000056977
ENSRNOP00000075140
ENSRNOT00000086650
ENSRNOG00000018058
ENSRNOP00000045395
ENSRNOT00000041474

MGI ID MGI:102672

RGD ID 620082

Unigene ID Hs.170019
Mm.378894
Rn.34220

Homologene ID 37914

Shape O-vertex