Protein TGFBR1

URN urn:agi-llid:4484
Total Entities 0
Connectivity 3496
Name TGFBR1
Description transforming growth factor beta receptor I
Notes The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway Osteoarthritis
Immunoglobulin Class-Switch Recombination Activation
Treg-Cell Differentiation
AHR Signaling in Treg and Dendritic Cells Function
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
anti-Inflammatory Function of Macrophage M2 Lineage
Vascular Endothelial Cell Activation by Growth Factors
Vascular Smooth Muscle Cell/Pericyte Differentiation and Proliferation
PRL Expression Regulation by BMP4 and TGFB1
G1/S Damage Checkpoint
Cell Cycle Overiew
Transcytosis
Cardiomyocyte Dysfunction
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Pulmonary Hypertension
BMP/TGF-beta Signaling Impairment in Pulmonary Hypertension
Lymphocyte Mediated Myocardial Injury in Myocarditis
Hair Follicle Keratinocyte Apoptosis
Androgens in Sebocyte Maturation
Androgens Promote Scalp Dermal Papilla Regression
T-Cells Differentiation Block in Psoriasis
TGF-beta Signaling in Skin Aging
Treg-Cell Function in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Treg-Cell Activation in Diabetes Mellitus
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Metastatic Colorectal Cancer
GUCY2C Signaling in Colorectal Cancer
Th17-Cell Activation in Crohn's Disease
Chronic Myeloid Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
TGFBR Signaling in Pancreatic Neoplasms
ADAM33 Role in Asthma
Th17-Cell Differentiation in Asthma
Osteoblast Function Decline in Gout
TGFB2 Signaling Impairement in Osteoarthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Skin Fibrosis
Th17-Cell Numbers Reduction in HIV
Hereditary Hemorrhagic Telangiectasia
Myostatin in Skeletal Muscles in Muscular Dystrophies
Myostatin-IGF1 Crosstalk in Skeletal Muscles in Muscular Dystrophies
Proteins with Altered Expression in Osteoarthritis
Bone Loss in Osteoporosis
Hyperparathyroidism, Secondary Effect
Blood-Brain Barrier Disruption in Epileptiform Disorders
Glioma Stem Cell Program Activation
Medulloblastoma
Proteins with Altered Expression in Breast Cancer
Breast Cancer
Ovarian Cancer
Proteins with Altered Expression in Ovarian Cancer
BMP Signaling Impairment in Granulosa Cell in POF
Prostate Cancer
Proteins Involved in Prostate Cancer
Cytokines Trigger Otitis Media
Podocyte Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
TGFBR3 -> ARRB2 Signaling
Dexamethasone Induced Osteoporosis
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
DNA Damage Checkpoint Impairment in Cancer
IL23A and IL17A Provoke Cancer-Associated Inflammation
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
Genes with Mutations in Cancer-Associated Evading of Growth Suppressors
Proteins with Altered Expression in Cancer-Associated Evading of Growth Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Invadopodia Formation in Cancer Cells
Skeletal Muscle Wasting in Cancer Cachexia
Treg Cells Promote Immunosuppression in Cancer Immune Escape
TGFBR -> AP-1 Signaling
TGFBR/BMPR -> SMAD2/3 Signaling
TGFBR -> CREB/ELK-SRF Signaling
TGFBR -> ATF/GADD/MAX/TP53 Signaling
TGFBR -> MEF/MYOD/MYOG Signaling
TGFBR1/AP-1 Signaling
TGF-beta Signaling
TGFB2-TGFBR1 Expression Targets
TGFB3-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
PPAR Psoriasis
prarg negative regulators, ps-positive
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
1_Differentiation of psoriatic T cells
3_TGFB signaling provokes endochondral ossification with osteophyte formation
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
2_Podocyte dysfunction in glomerulonephritis
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
2_Cardiomyocyte hypertrophy
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
4_2_Genes with mutations currently associated with ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Defective tolerance of autoreactive T-cell in T1D
Differentiation of psoriatic T cells

Group Genes with Susceptibility Loci Associated with Age-Related Macular Degeneration
Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 4484

LocusLink ID 4484
7046
21812
29591

Alias T beta R-I
TGF-beta type I and activin receptors
Transforming Growth Factor-beta RI
OTTMUSP00000007207
OTTHUMP00000021783
AU017191
activin A receptor type II-like kinase, 53kD
transforming growth factor beta (TGF-beta) receptor type I
TGF-beta R I
TGF-beta type I and activin receptor
TGF-beta 1 receptor
Tgfbr I
ESK2
OTTMUSP00000007205
activin A receptor type II-like kinase
ALK V
MSSE gene
TGFR-1
TGF-beta 1 receptors
AAT5
TbetaRI
TGF-beta I receptors
TGFR I
RP23-457P12.1
transforming growth factor-beta serine/threonine type I receptors
TGF-beta type I receptor
type I transforming growth factor-beta receptor
ESS I
TGF-beta 1Rs
Transforming Growth Factor-beta R I
MGC93659
activin A receptor type II-like kinase, 53kDa
Activin receptor-like kinase 5
transforming growth factor beta receptor I
TGF-beta receptor type I
type I transforming growth factor-beta receptors
multiple self-healing squamous epithelioma gene
LDS2A
transforming growth factor beta 1 receptor
transforming growth factor beta 1 receptors
T beta RI
LOC666236
ALK-5
TGFb1R
TGF-beta RI
multiple self-healing squamous epithelioma protein
LOC669553
TbetaR-I
ESS1
SKR4
LOC674605
TGFBR1
LDS1A
transforming growth factor-beta serine/threonine type I receptor
TGF-beta 1R
TGFb1Rs
TGR1_HUMAN
RP11-96L7.1
TGF-beta receptor type-1
TGR I
TBRI
Serine/threonine-protein kinase receptor R4
Activin receptor-like kinase V
transforming growth factor, beta receptor 1
TGR1
ALK5
LDS1
MSSE
TBR-i
ACVRLK4
activin A receptor type II-like protein kinase of 53kD
mutant transforming growth factor beta receptor I
transforming growth factor-beta receptor type I
transforming growth factor, beta receptor I
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)

EC Number 2.7.11.30

GO ID 0005524
0070411
0046332
0048185
0019838
0046872
0004672
0004674
0050431
0005025
0005024
0005114
0000186
0032924
0060978
0009952
0006915
0048844
0001824
0060317
0007050
0048870
0071560
0030199
0060982
0048701
0042118
0043542
1905223
0001837
0043062
0008354
0007507
0001701
0035556
0001822
0002088
0008584
0048762
0032331
0001937
2001237
0030512
0048663
0060017
0060389
0007389
0018105
0018107
0060037
0060391
2001235
0030307
0030335
0008284
0051272
0001938
0010718
1905007
0051491
0010628
0010862
0051897
0051496
1905075
0045893
0009791
0003342
0016579
0006468
0060043
0010717
0043393
0031396
0006355
0070723
0060021
0007165
0001501
0048705
0048538
0007179
0003223
0060412
0003222
0042060
0048179
0005923
0009986
0005768
0005887
0043231
0045121
0005634
0005886
0043235
0016301
0000166
0046982
0044877
0005102
0016740
0004675
0031625
0001525
0030154
0043066
0045602
1902894
0016310
0043065
1902895
0046777
0010468
0040008
0043627
0007178
0016324
0016323
0005901
0030054
0016021
0016020
0032991
0007568
0031100
0048565
0007566
0030324
0051602
0001666
0014070
0034695
0009636
0005623
0005622
0070022
0005057
0004702
0023014
0032403
0009790
0043234
0016772

KEGG ID hsa:7046
mmu:21812

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 4 26.02 cM

OMIM ID 190181
609192
132800

Rat chromosome position 5q22

Hugo ID 11772
HGNC:11772

Human chromosome position 9q22.33
9q22

Swiss-Prot Accession B4DXN7
P36897
Q5T7S2
B4DY26
P36897.1
Q64729
Q9D5H8
Q4FJL1
Q64729.1
Q5M9H3
P80204
P80204.1
Q6IR47
Q706C0
Q706C1
A2AJN0

PIR ID A49432
JC2061
JC2062

GenBank ID NC_000009
XM_011518949
XP_011517251
XM_017015063
XP_016870552
NM_001306210
NP_001293139
NM_004612
NP_004603
NM_001130916
NP_001124388
XM_011518950
XP_011517252
XM_024447658
XP_024303426
XM_011518948
XP_011517250
NG_007461
AH006005
AAC08998
AH007196
AAD02042
AH015633
ABD46753
AL162427
AY497473
AAR32097
CH471105
EAW58905
EAW58906
GU143401
ACZ58375
HB448229
CAZ91468
U51139
AJ420419
AJ619019
CAF02096
AJ619020
CAF02097
AK002171
AK129793
AK302059
BAG63449
AK302234
BAG63588
AL117597
BC038347
BC056247
BC071181
AAH71181
BX648917
EF142853
ABO93068
EF142854
ABO93069
L11695
AAA16073
P36897
NC_000070
NM_009370
NP_033396
NM_001312868
NP_001299797
XM_017320103
XP_017175592
NM_001312869
NP_001299798
AL772150
AL772232
CH466565
EDL02353
FB746001
CAT04599
AK007125
BAB24865
AK015337
BAB29802
AK153796
AK154381
BAE32548
BC063260
AAH63260
BY200044
CK637995
CT010393
CAJ18600
D25540
BAA05023
D28526
BAA05878
Q64729
NC_005104
XM_006238030
XP_006238092
NM_012775
NP_036907
AC_000073
AABR07048119
AABR07048120
AAHX01036783
CH474056
EDL78209
U48401
BC087035
AAH87035
BC091352
CB804748
CK844086
L26110
AAA83216
P80204
XM_005252150
XP_005252207
NC_018920
AF035662
AF035663
AF035664
AF035665
AF035666
AF035667
AF035668
AF035669
AF035670
AF054590
AF054591
AF054592
AF054593
AF054595
AF054597
AF054598
AMYH02021328
AMYH02021329
DQ383416
DQ383417
DQ383418
DQ383419
DQ383420
DQ383421
DQ383422
DQ383423
DQ383424
XM_006537756
XP_006537819
XM_006537757
XP_006537820
AC_000026
AAHY01035599
AAHY01035600
XR_592491
AC_000141
ABBA01042903
ABBA01042904

Swiss-Prot ID TGFR1_HUMAN
TGFR1_MOUSE
TGFR1_RAT

Cell Localization Cell membrane
Cell junction
Tight junction
Cell surface
Membrane raft
Cell junction, tight junction

Ensembl ID ENSG00000106799
ENSP00000364129.2
ENST00000374990.6
ENSP00000447297.1
ENST00000552516.5
ENSP00000364133.4
ENST00000374994.9
ENSP00000450052.1
ENST00000550253.1
ENSMUSG00000007613
ENSMUSP00000048501.7
ENSMUST00000044234.13
ENSMUSP00000103353.2
ENSMUST00000107725.2
ENSMUSP00000007757.8
ENSMUST00000007757.14
ENSMUSP00000123761.1
ENSMUST00000126171.8
ENSRNOG00000007036
ENSRNOP00000071347.1
ENSRNOT00000081090.1
ENST00000374994.8
ENSP00000364129
ENST00000374990
ENSP00000364133
ENST00000374994
ENSP00000450052
ENST00000550253
ENSP00000447297
ENST00000552516
ENSMUSP00000007757
ENSMUST00000007757
ENSMUSP00000048501
ENSMUST00000044234
ENSRNOP00000071347
ENSRNOT00000081090
ENSRNOG00000050760

MGI ID MGI:98728

RGD ID 3852

Unigene ID Rn.44402
Hs.494622
Mm.197552

Homologene ID 3177

Shape Stick-vertex