Protein CASP1

URN urn:agi-llid:834
Total Entities 0
Connectivity 4348
Name CASP1
Description caspase 1, apoptosis-related cysteine peptidase
Notes This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
ObjectType Protein

Pathway NOD-like Receptors
Dectin-1 (CLEC7A) Signaling
T-Cell Cytotoxic Mediated Cell Death
Toll-like Receptor Independent Sterile Inflammation
Axonal Transport
Inflammatory Reaction in Acne Vulgaris
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
Macrophage Function in Diabetes Mellitus Type 1
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction in Diabetes Mellitus Type 1
Crohn's Disease
Macrophage Dysfunction
Proteins Involved in Helicobacter Infections
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Antigen-Presenting Cell Role in Asthma
Proteins Involved in Gout
Monocytes Function in Gout
Proteins Involved in Osteoarthritis
Dendritic Cell Dysfunction in Psoriatic Arthritis
PAPA Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Proteins Involved in Huntington Disease
Proteins Involved in Retinitis Pigmentosa
HMGB1 and IL1B in Neuroinflammation
HMGB1 and IL1B in Neuronal Hyperexcitation
SOD1 Mutation
Proteins with Altered Expression in Amyotrophic Lateral Sclerosis
Proteins Involved in Amyotrophic Lateral Sclerosis
Proteins Involved in Age-Related Macular Degeneration
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
Genes with Mutations in Cancer-Associated Resisting to Cell Death
Suppression of Caspase Activity in Cancer
Apoptosis Evasion in Cancer: Overview
Elevated Receptors -> Expression Targets in Lymph Node
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Thymus
Elevated Receptors -> Expression Targets in Breast
e
pathway 4
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of body weight
Neighbors of body weight gain
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of bone mineral density
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of early mortality
Neighbors of viral load
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of systolic blood pressure
Neighbors of fasting plasma glucose
Neighbors of energy expenditure
Neighbors of left ventricular ejection fraction
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of recurrence rate
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of body weight
Neighbors of body weight gain
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of bone mineral density
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of early mortality
Neighbors of viral load
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of systolic blood pressure
Neighbors of fasting plasma glucose
Neighbors of energy expenditure
Neighbors of left ventricular ejection fraction
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of recurrence rate
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of aging
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of smooth muscle cell migration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte recruitment
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of T-cell response
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of sensitization
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of life span
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of hypertrophy
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of monocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of PBMC
Neighbors of microglia
Neighbors of mononuclear cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of mononuclear phagocyte
Neighbors of immunocompetent cell
Neighbors of myeloid cell
Neighbors of stem cell
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of chondrocyte
Neighbors of T-cell
Neighbors of neuroglia
Neighbors of hematopoietic cell
Neighbors of antigen-presenting cell
Neighbors of brain cell
Neighbors of liver
Neighbors of intestine
Neighbors of bone
Neighbors of brain
Neighbors of artery wall
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of NFKBI
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of growth factor
Neighbors of ovalbumin
Neighbors of chorionic gonadotropin
Neighbors of LXR
Neighbors of IL23
Neighbors of caspase
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
sars-cov no binding
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Mutations in SOD1 and associated proteins cause motor neuron death in familial ALS
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
drug-target pairs direct regulation
drug-target moltransport

Group other partners for SARS

MedScan ID 834
12342236

LocusLink ID 834
12362
25166

Alias interleukin 1beta precursor proteinase
caspase 1 isoform gamma
Interleukin-1 converting enzyme
pro-interleukin 1beta proteinase
pro-interleukin 1beta proteinases
pro-interleukin 1beta protease
prointerleukin 1beta proteases
prointerleukin 1beta proteinase
Casp I
IL1BC
interleukin 1, beta, convertase
apoptosis-related cysteine proteinase caspase 1
pro-interleukin 1beta proteases
caspase 1
interleukin-1beta convertases
prointerleukin 1beta proteinases
interleukin 1beta precursor proteases
caspase 1 isoform beta
interleukin IL1BC
interleukin 1beta precursor proteinases
interleukin 1-beta converting enzymes
IL-1B converting enzyme
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
caspase 1, apoptosis-related cysteine proteinase (interleukin 1, beta, convertase)
IL1 converting enzyme
interleukin 1-B converting enzyme
ICEs
IL-1 beta converting enzyme
interleukin 1 beta-converting enzyme
interleukin IL1B-convertase
Interleukin IL1 converting enzyme
caspase I
caspase 1 isoform epsilon
caspase 1 isoform delta
caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
IL1BCE
CASP1 nirs variant 1
apoptosis-related cysteine protease caspase 1
3.4.22.36
apoptosis-related cysteine peptidase caspase 1
interleukin IL1-beta convertase
interleukin IL-1 beta converting enzyme
interleukin IL1beta-converting endopeptidase
interleukin 1beta precursor protease
caspase 1, apoptosis-related cysteine peptidase
I1BC
interleukin IL1-B converting enzyme
ICE
interleukin 1 beta-converting endopeptidase
IL1B-convertase
prointerleukin 1beta protease
I1BC_HUMAN
IL1beta-converting endopeptidase
interleukin IL1BCE
CASP1
interleukin 1beta-converting endopeptidases
caspase 1 isoform alpha
P45
IL-1 beta-converting enzyme
caspase-1
CASP-1
IL-1BC
interleukin-1 beta convertase
interleukin-1 beta-converting enzyme
Interleukin 1beta converting enzyme
interleukin 1-beta converting enzyme
interleukin 1-beta-converting endopeptidase
interleukin-1 beta convertase precursor
interleukin 1 converting enzyme
interleukin 1-beta convertase

EC Number 3.4.22.36

GO ID 0050700
0008656
0004197
0097153
0097199
0004175
0019900
0006919
0006915
0097190
0071345
0071346
0071222
0071260
0071310
0019221
0097194
0043123
0043280
0032731
0050718
1903265
0016540
0006508
0042981
0007165
0097169
0072557
0072558
0072559
0005737
0005829
0005886
0097179
0032991
0008234
0016787
0008233
0097110
0032611
0060081
0007613
0001774
0051882
0007520
0043065
0046010
0050715
0050717
0097300
0016485
0070269
0010506
0050727
0033198
0009617
0042493
0001666
0032496
0014070
1901998
0005576
0043005
0005634
0030324
0007494
0009636
0005739
0005622
0008219
0097200
0045087
0006917
0035872
0005515
0042221
0043234
0008152

KEGG ID hsa:834
mmu:12362
rno:25166

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 9 2.46 cM
9 1.0 cM

OMIM ID 147678

Rat chromosome position 8q11

Hugo ID 1499
HGNC:1499

Human chromosome position 11q22.3
11q23

Swiss-Prot Accession P29466
A8K249
A8K257
P29466.1
P29452
P29452.1
Q91W32
P43527.1
B5MDZ1
Q53EY6
Q6DMQ1
Q6GSS3
Q6PI75
Q9UCN3
P43527
Q5FBZ0

PIR ID A54263
A56084
B56084
C56084
D56084
A46495

GenBank ID NC_000011
NM_033293
NP_150635
NM_001223
NP_001214
NM_033292
NP_150634
XM_017018395
XP_016873884
XM_017018394
XP_016873883
XM_017018393
XP_016873882
NM_033295
NP_150637
NM_033294
NP_150636
NM_001257119
NP_001244048
NM_001257118
NP_001244047
XM_017018396
XP_016873885
NG_029124
AP001153
CH471065
EAW67057
EAW67058
EAW67059
EAW67060
EAW67061
KF455483
L27475
AAD15243
AA505065
AA737419
AA761907
AB102878
BAD89407
AK223503
BAD97223
AK290114
BAF82803
AK290122
BAF82811
AK296646
BAG59246
AK301037
BAG62650
AK310059
AK313516
BAG36296
AY660536
AAT72297
BC041689
AAH41689
BC062327
AAH62327
M87507
AAA66942
U13697
AAC50107
U13698
AAC50108
U13699
AAC50109
U13700
AAC50110
X65019
CAA46153
P29466
NC_000075
NM_009807
NP_033937
AC141637
CH466636
EDL09320
EDL09321
EDL09322
EDL09323
U04269
AAA56992
AK132826
AK163069
BC008152
AAH08152
L03799
AAA39306
L28095
AAA20209
P29452
NC_005107
NM_012762
NP_036894
AC_000076
AABR07068939
AAHX01052962
CH474089
EDL85232
EDL85233
BC088098
D85899
BAB67770
FQ228818
S79676
AAB35431
U14647
AAA85812
U34621
AAC52259
P43527
AABR06052953
AAHY01030335
HQ447656
ABBA01039912
AC_000025
XM_011543017
XM_011543018
ADQ32141
XP_011541319
AC_000143
NC_018922
XM_006718924
XP_006718987
XP_011541320
AMYH02025506
NT_033899
NW_001838042
NW_925173
AC_000054
CR592117
Q5FBZ0
NT_039471
NW_001030736
NW_047797
NW_001084863
Q91W32

Swiss-Prot ID CASP1_HUMAN
CASP1_MOUSE
Q91W32_RAT

Cell Localization Cytoplasm
Cell membrane

Ensembl ID ENSG00000137752
ENSP00000432340.1
ENST00000527979.5
ENSP00000433138.1
ENST00000533400.6
ENSP00000434779.1
ENST00000525825.5
ENSP00000410076.3
ENST00000436863.7
ENSP00000434250.1
ENST00000526568.5
ENSP00000403260.1
ENST00000446369.5
ENSP00000344132.5
ENST00000353247.9
ENSMUSG00000025888
ENSMUSP00000027015.5
ENSMUST00000027015.5
ENSRNOG00000007372
ENSRNOP00000009993.5
ENSRNOT00000009993.6
ENST00000525825
ENST00000353247
ENSRNOP00000009993
ENST00000393136
ENSP00000432340
ENSMUST00000027015
ENST00000533400
ENST00000533400.5
ENSP00000433138
ENST00000436863
ENSP00000410076
ENST00000527979
ENST00000526568
ENSMUSP00000027015
ENSRNOT00000009993
ENST00000446369
ENSP00000376844
ENSP00000403260
ENSP00000434779
ENSP00000344132
ENSP00000434250

MGI ID MGI:96544
96544

RGD ID 2274

Unigene ID Hs.2490
Rn.37508
Mm.1051

Homologene ID 7653
133272

IPI ID IPI00219307
IPI00219308
IPI00219309
IPI00021800
IPI00219310
IPI00125676
IPI00201423
IPI00797075
IPI00903240
IPI00554551