Protein PTPN6

URN urn:agi-llid:5777
Total Entities 0
Connectivity 2384
Name PTPN6
Description protein tyrosine phosphatase, non-receptor type 6
Notes The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein phosphatase

Pathway DCIR1 (CLEC4A) Signaling
T-Cell Dependent B-Cell Activation
Natural Killer Cell Inhibitory Receptor Signaling
Peripheral T-Cell Tolerance
Treg-Cell Differentiation
T-Cell Receptor Signaling
Toll-like Receptors in Sterile Inflammation
Do not Eat me\xc2\x9d Signal: Viable Cells Inhibits Phagocytosis
Hemapoietic Stem Cell -> Lymphoid Multipotent Progenitor Surface Expression Markers
Atopic Dermatitis Onset
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Immune Sustem Activation in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
Immune System Activation in Hyperthyroidism
CD4+T-Cell Response in Celiac Disease
Celiac Disease
Dendritic Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Follicular Lymphoma
B-Cells Function in Systemic Scleroderma
IL6 Promotes Inflammation in Muscular Dystrophies
CD47 Repression by miRNAs
Alveolar Macrophage Negative Regulation Declined in COPD
B-Cell Receptor -> NFATC Signaling
B-Cell Receptor -> NF-kB Signaling
CD22 -> STAT Expression Targets
CD22 -> NF-kB Expression Targets
CD8 -> AP-1 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD72 -> NF-kB Expression Targets
CD72 -> NFATC Expression Targets
CD72 -> STAT Expression Target
CD80 -> STAT Expression Targets
CD81 Expression Targets
CD80 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD80 -> ATF/CREB/CREBBP Expression Targets
CD86 -> NFATC Expression Targets
CD86 -> ATF/CREB/CREBBP Expression Targets
CD86 -> STAT Expression Targets
CD86-> NFATC Expression Targets
CD86 -> NF-kB Expression Targets
Effector T-cell Inactivation in Cancer Immune Escape
PTPRJ Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
PDCD1 -> STAT Expression Targets
PDCD1 -> NF-kB Expression Targets
PDCD1 -> NFATC Expression Targets
PDCD1 -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
T-Cell Receptor -> NF-kB Signaling
T-Cell Receptor -> NFATC Signaling
T-Cell Receptor -> STAT Signaling
T-Cell Receptor -> ATF/CREB Signaling
T-Cell Receptor -> CREBBP Signaling
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
ace2
sialic
PPAR Psoriasis
New Pathway (3)
1_Differentiation of psoriatic T cells
1_The onset of atopic dermatitis
1_Th2 cell response in asthma
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_CD4+ T cell and epithelial cell response in celiac disease
2_Defective tolerance of autoreactive T-cell in T1D
Differentiation of psoriatic T cells

Group Genes Frequently Hypermethylated in Follicular Lymphoma

MedScan ID 5777

LocusLink ID 5777
15170
116689

Alias SH2-containing tyrosine phosphatase SHP-1
70Z-SHP
protein tyrosine phosphatase, non receptor type 6
SH-PTP1
Src homology region 2 domain (SH2)-containing tyrosine phosphatase-1
hematopoietic phosphotyrosine phosphatase SHP-1
hematopoietic cell protein-tyrosine phosphatase
SHP-1Ls
MGC124580
PTP-1Cs
Src homology domain 2 (SH2)-containing tyrosine phosphatase-1
PTPN6
Src homology region 2 domain-containing tyrosine phosphatase SHP-1
Src homology domain 2 containing protein phosphatase 1
motheaten
PTPTY-42
HCPH
SH2 phosphatase 1
Src homology region domain 2 (SH2)-containing tyrosine phosphatase-1
hemopoietic cell phosphatase
Src homology domain 2-containing tyrosine phosphatase SHP-1
SHP I
Src homology region domain 2-containing tyrosine phosphatase SHP-1
protein tyrosine phosphatase, nonreceptor type 6
SHP1 protein tyrosine phosphatase
Src homology region domain 2 containing protein phosphatase 1
phosphatase SHP1
SHP-1L
protein-tyrosine phosphatase 1C
Ptph6
HPTP1C
protein tyrosine phosphatase, non receptor type VI
protein-tyrosine phosphatase SHP-1
Src homology region 2 domain-containing protein phosphatase 1
SHP1
SHP 1 phosphatase
SH2 phosphatase I
protein tyrosine phosphatase, nonreceptor type VI
Ptp1C
hematopoietic cell phosphatase
70 kda SHP-1L protein
hematopoietic cell phophatase
SH-PTP I
HCP
SHP-1
PTP-1C
tyrosine-protein phosphatase non-receptor type 6
me
protein tyrosine phosphatase, non-receptor type 6
protein tyrosine phosphatase, non-receptor type VI
motheaten protein

EC Number 3.1.3.48

GO ID 0042169
0017124
0050839
0140031
0001784
0019901
0004725
0005001
0050853
0007186
0031295
0033277
0006915
0030154
0008283
0071345
0019221
0002244
0035556
0050900
0035855
0042267
0043407
0042130
0050860
0008285
0002924
0032715
0050732
0032720
0043312
0035335
0018108
0030168
0070527
0030220
0033630
0008284
0014068
0006470
0045577
0070372
2000045
0051279
0060338
0042105
0005911
0005737
0005829
0070062
0005576
0016020
0005730
0005654
0005634
0032991
0035580
1904724
0016787
0046703
0016791
0004721
0016311
0043409
0050859
0009611
0060397
0007596
0060333
0060334
0060337
0007165
0005622
0034329
0004872

KEGG ID rno:116689
hsa:5777
mmu:15170

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6 59.17 cM
6 60.22 cM

OMIM ID 176883

Rat chromosome position 4q42

Hugo ID 9658
HGNC:9658

Human chromosome position 12p13.31
12p13

Swiss-Prot Accession P29350
Q53XS4
P29350.1
P29351
Q3UB72
Q3UCJ0
P29351.2
P81718
P81718.1
A8K306
G3V0F8
Q969V8
Q9UK67
O35128
Q63872
Q63873
Q63874
Q921G3
Q9QVA6
Q9QVA7
Q9QVA8
Q9R0V6
Q53EL0
Q3TE70
Q499N7
Q8R5H0

PIR ID B42031
A44390

GenBank ID NC_000012
NM_080548
NP_536858
XM_011520988
XP_011519290
NM_080549
NP_536859
XM_006718994
XP_006719057
NM_002831
NP_002822
XM_024449106
XP_024304874
AB019535
AB079851
BAC81774
BAC81775
AH003242
AAA82879
CH471116
EAW88700
EAW88701
EAW88702
EAW88703
EAW88704
HI573994
CBX47486
HI573996
CBX47487
U47924
AAB51322
AAB51323
X82818
AF178946
AAD53317
AK223629
BAD97349
AK290421
BAF83110
AK298470
BAG60682
AK300167
BAG61949
AK308230
AK309037
AK313379
BAG36177
BC002523
AAH02523
BC007667
AAH07667
BG754792
BM006699
BM742181
BT007390
AAP36054
CR986427
DA431502
DA868001
DC297194
M74903
AAA35963
M77273
AAA36610
P29350
NC_000072
NM_001077705
NP_001071173
NM_013545
NP_038573
AC002397
AAC36008
AAC36009
AC164157
AH007124
AAD00151
AAD00152
CH466523
EDK99751
AK132509
BAE21210
AK150509
BAE29622
AK151077
BAE30092
AK151623
AK159686
AK159833
AK167923
AK169804
BAE41378
BC012660
AAH12660
BY035180
BY747031
M68902
AAA37796
M90389
AAA40007
S63763
AAP13944
S63764
AAP13945
S63803
AAP13953
P29351
NC_005103
NM_053908
NP_446360
AC_000072
AAHX01032846
AAHX01032847
AC129138
CH473964
EDM01944
EDM01945
AF468653
AAL77056
BC099824
AAH99824
FQ232747
U77038
AAD00262
P81718
XR_931520
XM_011520989
XP_011519291
NC_018923
AMYH02025958
U15528
AAA82880
U15529
U15530
U15531
U15532
U15533
U15534
U15535
U15536
U15537
DQ891946
ABM82872
DQ895133
ABM86059
AC_000028
AAHY01057229
U65951
U65952
U65953
U65954
U65955
AC_000144
ABBA01017669
ABBA01017670
NW_003871083
NT_009759
NW_925295
NW_001838050
AC_000055
CR590933
Q53EL0
Q53XS4
Q9UK67
NT_039353
NW_001030811
Q3TE70
Q3UB72
Q3UCJ0
NW_047696
NW_001084832
Q499N7
Q8R5H0

Swiss-Prot ID PTN6_RAT
PTN6_HUMAN
PTN6_MOUSE
Q3UCJ0_MOUSE
Q53XS4_HUMAN
Q9UK67_HUMAN
A8K306_HUMAN

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000111679
ENSP00000326010.9
ENST00000318974.14
ENSP00000382376.1
ENST00000399448.5
ENSP00000391592.1
ENST00000456013.5
ENSMUSG00000004266
ENSMUSP00000129124.2
ENSMUST00000171549.8
ENSMUSP00000108103.3
ENSMUST00000112484.9
ENSRNOG00000014294
ENSRNOP00000059867.1
ENSRNOT00000065416.3
ENST00000318974.13
ENSP00000326010
ENST00000318974
ENSP00000382376
ENST00000399448
ENSP00000391592
ENST00000456013
ENSMUSP00000129124
ENSMUST00000171549
ENSMUSP00000108103
ENSMUST00000112484
ENSRNOP00000059867
ENSRNOT00000065416

MGI ID MGI:96055
96055

RGD ID 620660

Unigene ID Hs.63489
Rn.18985
Mm.271799

Homologene ID 56589

Shape 2Triangles

IPI ID IPI00225419
IPI00225422
IPI00310909
IPI00183046
IPI00218604
IPI00396552
IPI00941721
IPI00339114
IPI00795221
IPI00789746