Pathway
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Osteoarthritis
|
|
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
|
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I-cell: CCK-8 Secretion and Regulation of Eating Behavior
|
|
Toll-like Receptors Act through MYD88-TIRAP Signaling
|
|
Antiviral Signaling through Pattern Recognition Receptors
|
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Toll-like Receptors Act through MYD88 Signaling
|
|
TLR4 Signaling in Leukocytes
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Independent B-Cell Activation
|
|
V(D)J Recombination Activation
|
|
Immunoglobulin Class-Switch Recombination Activation
|
|
T-Cell Maturation (Hypothesis)
|
|
CD8+ T-Cell Activation
|
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Th1-Cell Differentiation
|
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Treg-Cell Differentiation
|
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Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
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|
Th17-Cell Differentiation
|
|
Toll-like Receptors in Sterile Inflammation
|
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Toll-like Receptor Independent Sterile Inflammation
|
|
MC1R in anti-Inflammatory Signaling
|
|
Prostaglandin E2 Receptor Signaling in Neurons
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cell Activation without Degranulation
|
|
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
|
|
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
|
|
Macrophage M1 Lineage
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
AHR Signaling in M1 Macrophages Function
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
|
|
Neutrophil Recruitment and Priming
|
|
Negative Acute Phase Proteins Synthesis
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Positive Acute Phase Proteins Synthesis
|
|
Vascular Endothelial Cell Activation by Cytokines
|
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Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Adipokines Production by Adipocyte
|
|
GFs/TNF -> Ion Channels
|
|
IL1B Expression Targets -> Nociception
|
|
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
|
|
Proteins Involved in Atherosclerosis
|
|
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
|
|
Dendritic Cells Function in Atherosclerosis
|
|
RAGE/AGER and S100 Proteins in Cardiovascular Injury
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Myocardial Infarction
|
|
MAVS in Antiviral Innate Immune Response in Myocarditis
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Keratinocyte Proliferation in Acne Vulgaris
|
|
Atopic Dermatitis Onset
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
IL17 Signaling in Psoriasis
|
|
Dendritic Cells Function in Psoriasis
|
|
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
|
|
Dendritic Cell Activation in Systemic Lupus Erythematosis
|
|
Th17-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Toll-like Receptors in beta-Cell
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
|
|
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Insulin Resistance in Myocytes Induced by Obesity
|
|
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Destruction in Diabetes Mellitus Type 1
|
|
Bone Remodeling in Hyperthyroidism
|
|
Adipokines Production by Adipocyte Impaired in Obesity
|
|
CD4+T-Cell Response in Celiac Disease
|
|
Celiac Disease
|
|
Crohn's Disease
|
|
Dendritic Cell Dysfunction in Crohn's disease
|
|
Dendritic Cell Function in Ulcerative Colitis
|
|
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
|
|
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
Antiphospholipid Antibodies in Endothelial Cell
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Diffuse Large-B-Cell Lymphoma ABC Subtype
|
|
Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
Mantle Cell Lymphoma
|
|
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
|
|
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
|
|
Splenic Marginal Zone Lymphoma
|
|
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
|
|
Osteoclast Activation in Multiple Myeloma
|
|
Multiple Myeloma
|
|
Proteins Involved in Multiple Myeloma
|
|
Antiphospholipid Antibodies and Endothelial Cell Interaction
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Eosinophil Survival in Asthma
|
|
Il17 Signaling Related Neutrophilia in Asthma
|
|
IL33 Signaling Related Eosinophilia in Asthma
|
|
TSLP Signaling in Bronchial Epithelial Cell in Asthma
|
|
IL17F Signaling in Bronchial Epithelial Cell in Asthma
|
|
Club-Cell Role in Asthma
|
|
Basophil Activation in Asthma
|
|
Antigen-Presenting Cell Role in Asthma
|
|
B-Cell Mediated IgE Production in Asthma
|
|
Th17-Cell Differentiation in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
|
|
Airway Epithelial Cell Dysfunction
|
|
CFTR Expression in Epithelial Cells (Class I Mutations)
|
|
Osteoclast Activation in Gout
|
|
Neutrophil Recruitment in Sinovium in Gout
|
|
Monocytes Function in Gout
|
|
Hyper IgM Syndrome
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
IL1B Induced Arthralgia
|
|
Dendritic Cell Dysfunction in Psoriatic Arthritis
|
|
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
|
|
Osteoclast Activation in Psoriatic Arthritis
|
|
Synovial Fibroblast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
|
|
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
|
|
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
Dentin Formation Disruption
|
|
Th17-Cell Numbers Reduction in HIV
|
|
CD4+ T-Cell Function Decline in HIV
|
|
CD4+ T-Cell Death in HIV
|
|
Toll-like Receptors (TLR) in Periodontitis
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
PAPA Syndrome
|
|
TNF Receptor Associated Periodic Syndrome
|
|
Mevalonate Kinase Deficiency
|
|
Blau Syndrome
|
|
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
|
|
Cryopyrin (NLPR3) Associated Periodic Syndromes
|
|
Familial Cold Autoinflammatory Syndrome 2
|
|
Familial Mediterranean Fever
|
|
Majeed Syndrome
|
|
Gluten Impact on Neuronal System (Hypothesis)
|
|
Osteoclasts Function in Osteopetrosis
|
|
Proteins Involved in Osteopetrosis
|
|
Osteoclast Activation in Postmenopause
|
|
Microglia Activation in Alzheimer's Disease
|
|
HMGB1 and IL1B in Neuroinflammation
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
Microglia Activation in Parkinson's Disease
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
|
|
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
|
|
Cytokines Trigger Otitis Media
|
|
MUC5AC Expression by NTHi and S. Pneumoniae
|
|
Immune System Role in Otitis Media
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Alveolar Macrophages Dysfunction in COPD
|
|
T-Cell Cytotoxic Activation
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Toll-like Receptors in Pyelonephritis
|
|
Endothelial Cell Dysfunction in Pyelonephritis
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
B-Cell Receptor -> NF-kB Signaling
|
|
TLR -> ARRB2/NF-kB Signaling
|
|
gamma Globulins Expression Targets
|
|
CD22 -> NF-kB Expression Targets
|
|
CD72 -> STAT Expression Target
|
|
CD8 -> STAT Expression Targets
|
|
CD80 -> STAT Expression Targets
|
|
CD86 -> STAT Expression Targets
|
|
PECAM1 Expression Targets
|
|
NFKB Canonical Signaling Activation in Cancer
|
|
NFKB Non-Canonical Signaling Activation in Cancer
|
|
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
|
|
IL23A and IL17A Provoke Cancer-Associated Inflammation
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
NFKB Signaling Activation by Blocking of Tumor Suppressors
|
|
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
|
|
IDO1 in Cancer Immune Escape
|
|
IFNLR1-> STAT/NFKB Signaling
|
|
IL1R -> STAT3 Signaling
|
|
IL1R -> NF-kB Signaling
|
|
IL16 -> NF-kB Expression Targets
|
|
CD40 -> Expression Targets in Lymph Node
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
NGF -> AP-1/TP53/MYC Expression Targets
|
|
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
NGF -> CREB/CEBPB/MEF2A Expression Targets
|
|
PDCD1 -> NF-kB Expression Targets
|
|
DDR1 -> NF-kB Signaling
|
|
Collagen -> NF-kB Expression Targets
|
|
JNK/MAPK Signaling
|
|
TGF-beta Signaling
|
|
P38 MAPK/MAPK14 Signaling
|
|
NF-kB non-Canonical Signaling
|
|
ERK5/MAPK7 Signaling
|
|
NF-kB Canonical Signaling
|
|
TCR -> NF-kB Expression Targets
|
|
T-Cell Receptor -> AP-1 Signaling
|
|
T-Cell Receptor -> NF-kB Signaling
|
|
CD72 -> AP-1 Expression Targets
|
|
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
|
|
TNFSF13 Expression Targets
|
|
TNFSF13B Expression Targets
|
|
EDA Expression Targets
|
|
EctodysplasinR -> NF-kB Signaling
|
|
EctodysplasinR -> AP-1 Signaling
|
|
TNFR -> CREB/ELK-SRF Signaling
|
|
TNFR -> AP-1/ATF/TP53 Signaling
|
|
TNFRSF5/13B -> NFATC1 Signaling
|
|
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
|
|
TNFRSF5/6 -> RB1/E2F Signaling
|
|
NGFR -> NF-kB Signaling
|
|
EctodysplasinR -> LEF1 Signaling
|
|
TNFR -> NF-kB Signaling
|
|
NGFR -> MEF Signaling
|
|
TLR4 -> AP-1 Expression Targets
|
|
TLR5 Expression Targets
|
|
TLR7 Expression Targets
|
|
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
|
|
TLR1 -> 2/6 Expression Targets
|
|
IL1B Expression Targets
|
|
TLR4 -> NF-kB/IRF Expression Targets
|
|
IL1A Expression Targets
|
|
TLR9 Expression Targets
|
|
TLR4/5/7/9 -> NF-kB Signaling
|
|
TLR1/2/6 -> NF-kB Signaling
|
|
TLR -> AP-1 Signaling
|
|
pathway 4
|
|
Model of PPARG signaling in psoriasis
|
|
Model of PPARG related pathways in psoriasis (short version)
|
|
New Pathway (3)
|
|
sars-cov no binding
|
|
dsRNA induces innate immunity and INFs in alveolar cells
|
|
IFN signaling in alveolar cells
|
|
Innate immunity in Leukocytes
|
|
AGER feed forward loop in innate immunity
|
|
Dendritic Cell Activation in COVID19
|
|
1_Inflammation in keratinocytes in the pathology of acne
|
|
2_Acute phase initiation in atopic dermatitis
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
1_The onset of atopic dermatitis
|
|
1_TNF and IL1B provoke ECM degradation in osteoarthritis
|
|
1_Osteoclast-mediated bone resorption in postmenopausal women
|
|
1_Osteoclast functional impairment in osteopetrosis
|
|
2_Chondrocyte death in osteoarthritis
|
|
1_The role of Toll-like receptors in pyelonephritis
|
|
2_The role of endothelial cells in pyelonephritis
|
|
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
|
|
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
|
|
2_Pathogens stimulate mucins expression in the middle ear
|
|
3_Arterial wall inflammation and calcification in atherosclerosis
|
|
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
|
|
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
|
|
1_Th2 cell response in asthma
|
|
3_2_Regulation of airway surface liquid (ASL) thickness
|
|
3_1_Mucus accumulation in asthma
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
2_Paneth cell dysfunction in Crohn's disease
|
|
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
|
|
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
|
|
1_Intestine epithelial cell dysfunction in ulcerative colitis
|
|
2_Lipotoxicity in NAFLD
|
|
1_CD4+ T cell and epithelial cell response in celiac disease
|
|
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
|
|
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
|
|
4_3_Insulin resistance: FFA-related insulin resistance
|
|
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
|
|
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
|
|
3_Islet beta-cell destruction in T1D
|
|
2_Neuron and Schwann cell death
|
|
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
|
|
Model of PPARG signaling in psoriais (tested)
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|