Pathway
|
Osteoarthritis
|
|
Skin Aging
|
|
Oncogene Induced Cellular Senescence
|
|
MTHFR Activity Regulation
|
|
Melatonin Effects on Circadian Cycle
|
|
N-cell: Neurotensin Production
|
|
Dopamine Receptors Signaling
|
|
Prolactin Production
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
Cortisol in Resolving Inflammation
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Independent B-Cell Activation
|
|
Natural Killer Cell Activation through C-Type Lectin-like Receptors
|
|
Natural Killer Cell Activation through ITAM-Containing Receptors
|
|
Natural Killer Cell Activation through ITSM-Containing Receptors
|
|
Natural Killer Cell Activation
|
|
CD8+ T-Cell Activation
|
|
Plasmin Effects in Inflammation
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
Lipoxin A4/FPR2-Related Neutrophil Depression
|
|
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
|
|
Mast-Cell Activation without Degranulation through CXCR4 Signaling
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
|
|
Neutrophil Recruitment and Priming
|
|
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Adipokines Production by Adipocyte
|
|
Nociception Expression Targets Signaling
|
|
NTSR1 Expression Targets
|
|
ADRA1A -> IL6 Production
|
|
CNR1/2 -> IL1B/2/4/6/10 Production
|
|
DRD2 Expression Targets
|
|
DRD1/5 Expression Targets
|
|
CHRM1 -> IL2 Production
|
|
PTGER2/3 -> Inflammation-Related Expression Targets
|
|
IL1B Expression Targets -> Nociception
|
|
Melatonin in Cell Survival and Antioxidant Response
|
|
Cell Cycle Overiew
|
|
G0/G1 Phase Transition
|
|
SCF/FBXW7 Complex
|
|
Proteins Involved in Atherosclerosis
|
|
Dendritic Cells Function in Atherosclerosis
|
|
RAGE/AGER and S100 Proteins in Cardiovascular Injury
|
|
Proteins Involved in Hypertrophic Cardiomyopathy
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Endothelin Signaling in Arterial Hypertension
|
|
Arterial Hypertension
|
|
Endothelial Cell Dysfunction in Arterial Hypertension
|
|
Aldosterone Synthesis Chronic Regulation
|
|
Smooth Muscle Cell Dysfunction in Arterial Hypertension
|
|
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
|
|
Myocardial Remodeling
|
|
Proteins Involved in Myocardial Ischemia
|
|
Sebocyte Proliferation in Acne Vulgaris
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
IL17 Signaling in Psoriasis
|
|
Proteins Involved in Psoriasis
|
|
IL22 Induces Keratinocyte Proliferation in Psoriasis
|
|
Proteins Involved in Photoaging
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
Humoral Immunity in Vitiligo
|
|
CD8+ T-Cell Response to Self-Determinants in Diabetes
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
|
|
Protein Kinase C in Diabetic Microangiopathy
|
|
Peripheral Tissue Microangiopathy
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
Microangiopathy in Diabetic Neuropathy
|
|
Proliferative Diabetic Retinopathy
|
|
Proteins Involved in Insulin Resistance
|
|
Adiponectin Synthesis Declines in Insulin Resistance
|
|
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Mass Regulation
|
|
Hypothyrodism Associated Hyperprolactinemia
|
|
DRD2 Pharmacological Inhibition in Hyperprolactinemia
|
|
Ethanol Induced Efects in Hyperprolactinemia
|
|
Thyroid Dysfunction
|
|
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
|
|
Myocyte Dysfunction in Hypoparathyroidism
|
|
Adipokines Production by Adipocyte Impaired in Obesity
|
|
Prolactinoma Overiew
|
|
CD8+ T-Cell Response in Celiac Disease
|
|
Proteins Involved in Colorectal Neoplasms
|
|
GUCY2C Signaling in Colorectal Cancer
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
CagA Phosphorylation Dependent Signaling
|
|
Peutz-Jeghers Syndrome
|
|
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
Proteins Involved in Acute Myeloid Leukemia
|
|
Antiphospholipid Antibodies in Endothelial Cell
|
|
Proteins Involved in Antiphospholipid Syndrome
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Chronic Myeloid Leukemia
|
|
Follicular Lymphoma
|
|
Osteoclast Activation in Multiple Myeloma
|
|
Multiple Myeloma
|
|
Antiphospholipid Antibodies and Endothelial Cell Interaction
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Proteins Involved in Hepatocellular Carcinoma
|
|
NOTCH Signaling in Hepatocellular Carcinoma
|
|
WNT Signaling in Hepatocellular Carcinoma
|
|
Hepatocellular Carcinoma
|
|
Growth Factor Signaling in Hepatocellular Carcinoma
|
|
Pancreatic Ductal Carcinoma
|
|
Growth Factor Signaling in Pancreatic Neoplasms
|
|
Pancreatic Neuroendocrine Tumors
|
|
TRPM7/8 in Pancreatic Adenocarcinoma
|
|
TGFBR Signaling in Pancreatic Neoplasms
|
|
TSLP Signaling in Bronchial Epithelial Cell in Asthma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
Osteoclast Activation in Gout
|
|
Monocytes Function in Gout
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
Ovulation Block
|
|
FSH Action in Polycystic Ovary Syndrome
|
|
Synovial Fibroblast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
Proteins Involved in Psoriatic Arthritis
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
|
|
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
|
|
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
|
|
B-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
CCR5 Signaling in Macrophages
|
|
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
|
|
Diabetes Induced Periodontitis
|
|
Estrogen Effects on Pregnancy Gingivitis
|
|
Majeed Syndrome
|
|
Hereditary Breast and Ovarian Cancer Syndrome
|
|
Cowden Syndrome
|
|
Proteins Involved in Huntington Disease
|
|
Oxytocin Signaling in Brain Nerve Cell (Hypothesis)
|
|
IL6 Promotes Inflammation in Muscular Dystrophies
|
|
IL6 Overexpression After Contraction in Skeletal Muscles in Muscular Dystrophies
|
|
Ca2+ Overload in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
|
|
IGF1 Role in Muscle Hypertrophy
|
|
Proteins Involved in Osteopetrosis
|
|
Osteoblast Function Decline in Osteoporosis
|
|
Osteoclast Activation in Postmenopause
|
|
Proteins Involved in Alzheimer's Disease
|
|
Metals and Amyloid beta Toxicity in Alzheimer's Disease
|
|
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
|
|
Glioma Invasion Signaling
|
|
Proteins Involved in Medulloblastoma
|
|
Proteins Involved in Parkinson's Disease
|
|
Proteins Involved in Amyotrophic Lateral Sclerosis
|
|
Microglia and Motor Neuron Interaction Dysregulation
|
|
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to NOTCH Signaling Pathway
|
|
WNT Signaling in Breast Cancer
|
|
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
|
|
Breast Cancer
|
|
ESR1 Signaling in Breast Cancer
|
|
NOTCH1 Signaling in Breast Cancer
|
|
Endometrial Cancer
|
|
Endometrioid Endometrial Cancer
|
|
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
|
|
Angiogenesis in Endometriosis
|
|
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
|
|
Leptin Role in Endometriosis
|
|
Proteins Involved in High-Grade Serous Ovarian Carcinoma
|
|
Endometrioid Ovarian Carcinoma
|
|
Proteins Involved in Endometrioid Ovarian Carcinoma
|
|
Clear Cell Ovarian Carcinoma
|
|
Proteins Involved in Mucinous Ovarian Carcinoma
|
|
High-Grade Serous Ovarian Carcinoma
|
|
Low-Grade Serous Ovarian Carcinoma
|
|
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
|
|
Ovarian Cancer
|
|
Proteins Involved in Clear Cell Ovarian Carcinoma
|
|
Mucinous Ovarian Carcinoma
|
|
MIF Role in Cholesteatoma
|
|
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV Infection and Cancer
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
Kruppel-like Factor 6 Signaling in Prostate Cancer
|
|
TRPM8 Effects in Prostate Cancer (Hypothesis)
|
|
ER Stress in Macular Degeneration
|
|
Steroids Induced Cataract
|
|
VEGFA in Neovascular Glaucoma
|
|
PGF2-alpha Effect on Treatment
|
|
MUC5AC Expression by NTHi and S. Pneumoniae
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Alveolar Macrophages Dysfunction in COPD
|
|
VEGFA Low Expression Level in Chronic Bronchitis
|
|
T-Cell Cytotoxic Activation
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
WNT Signaling in Cystic Kidney Disease
|
|
Polycystins Mutation Effects in Cystic Kidney Disease
|
|
Plasmin Role in Glomerulonephritis
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Mesangial Cell Dysfunction in Glomerulonephritis
|
|
Interstitial Fibroblasts in Pyelonephritis
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
CD38 -> cADPR/Calcium Signaling
|
|
S100B Expression Targets
|
|
ANGPT2 -> STAT Expression Targets
|
|
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
|
|
AREG -> AP-1 Expression Targets
|
|
Noradrenaline/Gs Expression Targets
|
|
Dopamine/Gs Expression Targets
|
|
Noreadrenaline/Gq Expression Targets
|
|
Epinephrine/Gs Expression Targets
|
|
Acetylcholine Expression Targets
|
|
Serotonin/Gq Expression Targets
|
|
Epinephrine/Gq Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
B-Cell Receptor -> AP-1 Signaling
|
|
BMP2/BMPR2 Expression Targets
|
|
BMP4/BMPR2 Expression Targets
|
|
BMP7/BMPR2/ACVR2 Expression Targets
|
|
BTC -> AP-1/ATF/CREB Expression Targets
|
|
Elevated Receptors -> Expression Targets in Bone and Joint
|
|
AGTR1 -> ARRB1/ARRB2 Signaling
|
|
CD19 Expression Targets
|
|
CD81 -> AP-1 Expression Targets
|
|
CD247 Expression Targets
|
|
gamma Globulins Expression Targets
|
|
CD19/CR2 Expression Targets
|
|
CD72 -> CREB/CREBBP Expression Targets
|
|
CD8 -> ATF/CREB/CREBBP Expression Targets
|
|
CD80 -> NF-kB Expression Targets
|
|
CD86 -> NF-kB Expression Targets
|
|
Elevated Receptors -> Expression Targets in Myocardium
|
|
CXCL12 Expression Targets
|
|
CSF2 -> STAT Expression Targets
|
|
LIF Expression Targets
|
|
Clozapine Induced Granulocytopenia
|
|
EGF -> CTNN Expression Targets
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
EGF -> MEF/MYOD/NFATC Expression Targets
|
|
EGF -> STAT Expression Targets
|
|
EGFR -> AP-1/ATF2 Signaling
|
|
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
|
|
EREG -> AP-1/ATF Expression Targets
|
|
Erythropoietin -> NF-kB Expression Targets
|
|
Erythropoietin -> AP-1/MYC/CREB Expression Targets
|
|
Erythropoietin -> ELK/SRF Expression Targets
|
|
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
F2 -> STAT1/NF-kB Expression Targets
|
|
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
PLG -> STAT1/NF-kB Expression Targets
|
|
FGF9 -> AP-1/CREB/MYC Expression Targets
|
|
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> STAT Expression Targets
|
|
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
FGF18 -> STAT Expression Targets
|
|
FGF18 -> AP-1/CREB Expression Targets
|
|
FGF1 -> STAT Expression Targets
|
|
FGF4 -> AP-1/MYC Expression Targets
|
|
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
|
|
FrizzledR -> JUN/PAX2 Signaling
|
|
GCG Expression Targets
|
|
FSHR Expression Targets
|
|
VIP Expression Targets
|
|
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
|
|
GH1/GHR -> STAT Expression Targets
|
|
GH1/PRLR Expression Targets
|
|
HBEGF -> AP-1/ATF Expression Targets
|
|
HGF -> STAT Expression Targets
|
|
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
HGFR -> AP-1/CREB/MYC Signaling
|
|
TAM Receptor Signaling Activation in Cancer
|
|
G0/G1 Cell Cycle Phase Transition Activation in Cancer
|
|
RAS/RAF/MAPK Signaling Activation in Cancer
|
|
WNT Canonical Signaling Activation in Cancer
|
|
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
|
|
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
|
|
WNT Signaling Activation by Blocking of Tumor Suppressors
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
VEGFA Dependent Angiogenesis in Cancer
|
|
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
|
|
Integrins in Cancer Cell Motility, Invasion and Survival
|
|
MTOR/TORC in Cancer Cell Motility and Invasion
|
|
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
IGF1 -> MEF/MYOD/MYOG Expression Targets
|
|
IGF1 -> STAT Expression Targets
|
|
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
INHBA/ACVR2/BMPR Expression Targets
|
|
Insulin -> STAT Expression Targets
|
|
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
|
|
Insulin -> MEF/MYOD Expression Targets
|
|
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
CD19 -> JUN/ELK Signaling
|
|
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
|
|
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
|
|
CTGF -> AP-1/CREB/MYC Expression Targets
|
|
ICAM1 Expression Targets
|
|
EGFR -> Expression Targets in Skin
|
|
IFNG/IFNR Expression Targets
|
|
IL7 Expression Targets
|
|
IL16 -> AP-1 Expression Targets
|
|
IL3 Expression Targets
|
|
IL6 Expression Targets
|
|
IL2 Expression Targets
|
|
PTPRJ Expression Targets
|
|
Leptin -> STAT Expression Targets
|
|
Leptin -> ELK/SRF Expression Targets
|
|
Prostaglandin F Expression Targets
|
|
Thromboxane A2 Expression Targets
|
|
LPA Expression Targets
|
|
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
|
|
Dronabinol/Anandamide Expression Targets
|
|
Morphine Expression Targets
|
|
S1P Expression Targets
|
|
PGE1 Expression Targets
|
|
MTNR1 Signaling
|
|
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
|
|
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
NRG1/Catenin Expression Targets
|
|
NRG1 -> STAT Expression Targets
|
|
NRG1 -> AP-1/ATF Expression Targets
|
|
Elevated Receptors -> Expression Targets in Nerve Tissue
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
NGF -> AP-1/TP53/MYC Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
Adenosine Expression Targets
|
|
PDGFB -> AP-1/CREB/MYC Expression Target
|
|
PDGFD -> AP-1 Expression Targets
|
|
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PDGF -> STAT Expression Targets
|
|
PDGFR -> AP-1/MYC Signaling
|
|
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
GNRH1 Expression Targets
|
|
NTS Expression Targets
|
|
GAST Expression Targets in GAST Expression Targets
|
|
GNRH2 Expression Targets
|
|
POMC Expression Targets
|
|
CCL11 Expression Targets
|
|
EDN1 Expression Targets
|
|
AGT -> CREB Expression Targets
|
|
NPY Expression Targets
|
|
AVP/Gq -> STAT Expression Targets
|
|
TAC1 Expression Targets
|
|
AVP/Gs -> STAT Expression Targets
|
|
EDN3 Expression Targets
|
|
AGT -> STAT Expression Targets
|
|
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
PRL/PRLR Expression Targets
|
|
PRL/GHR -> STAT Expression Targets
|
|
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
|
|
PDCD1 -> AP-1 Expression Targets
|
|
AngiopoietinR -> AP-1 Signaling
|
|
EphrinB -> MAPK/JUN/FOS Signaling
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
CSF1 -> STAT Expression Targets
|
|
GAS6 -> AP-1/CREB Expression Targets
|
|
FIGF -> AP-1 Expression Target
|
|
KITLG -> STAT Expression Targets
|
|
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
GDNF -> HSF1 Expression Targets
|
|
PAF Expression Targets
|
|
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
|
|
TGFBR -> AP-1 Signaling
|
|
TGFBR1/AP-1 Signaling
|
|
MSTN/ACVR2/BMPR Expression Targets
|
|
TNF-alpha/TNFRSF1A Signaling
|
|
Lysophosphatidic Acid/LPARs Signaling
|
|
JNK/MAPK Signaling
|
|
Estrogens/ESR1 Genomic Canonical Signaling
|
|
MERTK Signaling
|
|
TGF-beta Signaling
|
|
BMPR2 Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
TNF-alpha/TNFRSF1B Signaling
|
|
VEGF Signaling
|
|
Estrogens/ESR1 non-Genomic Signaling
|
|
EGFR Signaling
|
|
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
|
|
HRAS Signaling
|
|
ERK/MAPK Canonical Signaling
|
|
TCR -> AP-1 Expression Targets
|
|
TGFA -> STAT Expression Targets
|
|
TGFA -> CTNNB/CTNND Expression Targets
|
|
TGFA/AP-1/ATF Expression Targets
|
|
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
|
|
TGFB3-TGFBR2 Expression Targets
|
|
TGFB2-TGFBR2 Expression Targets
|
|
TGFB1-TGFBR2 Expression Targets
|
|
TGFB1-TGFBR1/AP-1 Expression Targets
|
|
TGFB1-ACVRL1 Expression Targets
|
|
FASLG Expression Targets
|
|
TNFSF10 Expression Targets
|
|
LTA Expression Targets
|
|
TNFSF14 Expression Targets
|
|
TNF -> AP-1 Expression Targets
|
|
CD72 -> AP-1 Expression Targets
|
|
TNFSF13 Expression Targets
|
|
TNFSF13B Expression Targets
|
|
EDA Expression Targets
|
|
EctodysplasinR -> AP-1 Signaling
|
|
TNFR -> AP-1/ATF/TP53 Signaling
|
|
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
|
|
TNFRSF1A -> AP-1/ATF/TP53 Signaling
|
|
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
TLR4 -> AP-1 Expression Targets
|
|
TLR5 Expression Targets
|
|
TLR7 Expression Targets
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IL1B -> NO Expression Targets
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TLR4 -> AP-1/EGR1/HIF1A Expression Targets
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IL1B -> PGE2 Expression Targets
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TLR1 -> 2/6 Expression Targets
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IL1B Expression Targets
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IL1A Expression Targets
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TLR9 Expression Targets
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TLR -> AP-1 Signaling
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VEGFA -> ATF/CREB/ELK-SRF Expression Targets
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VEGFA -> STAT Expression Targets
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VEGFA -> AP-1/CREBBP/MYC Expression Targets
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VEGFA -> CTNNB/CTNND Expression Targets
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VEGFR -> AP-1/CREB/MYC Signaling
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WNT1 Expression Targets
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WNT3A Expression Targets
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WNT4 Expression Targets
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WNT5A Expression Targets
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WNT7A Expression Targets
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pathway 3
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n
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ace2
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prarg negative regulators, ps-positive
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PPARG negative regulators
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pparg expr target_regulators
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Neighbors of disease exacerbation
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Neighbors of tumor progression
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Neighbors of cancer progression
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Neighbors of inflammatory status
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Neighbors of overall survival
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Neighbors of tumor size
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Neighbors of mortality
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Neighbors of survival rate
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Neighbors of infarct size
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Neighbors of survival time
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Neighbors of functional recovery
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Neighbors of insulin sensitivity
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Neighbors of bacterial load
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Neighbors of cancer survival
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Neighbors of lethality
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Neighbors of recurrence-free survival
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Neighbors of macrophage count
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Neighbors of long-term survival
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Neighbors of treatment outcome
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Neighbors of body weight
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Neighbors of tumor promotion
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Neighbors of morbidity
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Neighbors of mortality rate
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Neighbors of exhaustion
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Neighbors of radioresistance
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Neighbors of cell density
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Neighbors of apoptosis rate
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Neighbors of viral load
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Neighbors of tumor grade
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Neighbors of tumor resistance
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Neighbors of renal hypertrophy
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Neighbors of radiosensitivity
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Neighbors of pregnancy outcome
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Neighbors of metabolic response
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Neighbors of disease exacerbation
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Neighbors of tumor progression
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Neighbors of cancer progression
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Neighbors of inflammatory status
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Neighbors of overall survival
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Neighbors of tumor size
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Neighbors of mortality
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Neighbors of survival rate
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Neighbors of infarct size
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Neighbors of survival time
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Neighbors of functional recovery
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Neighbors of insulin sensitivity
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Neighbors of bacterial load
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Neighbors of cancer survival
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Neighbors of lethality
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Neighbors of recurrence-free survival
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Neighbors of macrophage count
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Neighbors of long-term survival
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Neighbors of treatment outcome
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Neighbors of body weight
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Neighbors of tumor promotion
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Neighbors of morbidity
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Neighbors of mortality rate
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Neighbors of exhaustion
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Neighbors of radioresistance
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Neighbors of cell density
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Neighbors of apoptosis rate
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Neighbors of viral load
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Neighbors of tumor grade
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Neighbors of tumor resistance
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Neighbors of renal hypertrophy
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Neighbors of radiosensitivity
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Neighbors of pregnancy outcome
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Neighbors of metabolic response
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Neighbors of cell development
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Neighbors of immune response
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Neighbors of cell population
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Neighbors of T-cell development
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Neighbors of inflammatory response
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Neighbors of wound healing
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Neighbors of angiogenesis
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Neighbors of innate immune response
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Neighbors of cell function
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Neighbors of macrophage activation
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Neighbors of cell formation
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Neighbors of osteoclast development
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Neighbors of epithelial to mesenchymal transition
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Neighbors of immunity
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Neighbors of cell proliferative response
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Neighbors of dendritic cell differentiation
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Neighbors of cell survival
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Neighbors of osteoclast differentiation
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Neighbors of cell phenotype
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Neighbors of T-cell proliferation
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Neighbors of tissue remodeling
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Neighbors of cell adhesion
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Neighbors of T-cell activation
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Neighbors of endothelial cell proliferation
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Neighbors of fibrogenesis
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Neighbors of tumor growth
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Neighbors of dendritic cell development
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Neighbors of tissue repair
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Neighbors of cell count
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Neighbors of cell infiltration
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Neighbors of cell interaction
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Neighbors of SMC proliferation
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Neighbors of lumen formation
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Neighbors of endothelial cell migration
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Neighbors of adipogenesis
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Neighbors of lipid storage
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Neighbors of cell damage
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Neighbors of pregnancy
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Neighbors of monocyte differentiation
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Neighbors of aging
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Neighbors of cell motility
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Neighbors of bone resorption
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Neighbors of fibroblast proliferation
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Neighbors of adipocyte differentiation
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Neighbors of microglial activation
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Neighbors of regeneration
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Neighbors of cell migration
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Neighbors of cancer growth
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Neighbors of stem cell proliferation
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Neighbors of smooth muscle cell migration
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Neighbors of hepatic regeneration
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Neighbors of transendothelial migration
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Neighbors of osteoclast formation
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|
Neighbors of cell invasion
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Neighbors of heart function
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Neighbors of hemopoiesis
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Neighbors of bone remodeling
|
|
Neighbors of ossification
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Neighbors of T-cell function
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Neighbors of immune system function
|
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Neighbors of lung development
|
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Neighbors of autophagy
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|
Neighbors of monocyte adhesion
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Neighbors of transcription activation
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Neighbors of senescence
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|
Neighbors of hepatocyte proliferation
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|
Neighbors of cell transdifferentiation
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|
Neighbors of neuroprotection
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Neighbors of stem cell differentiation
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|
Neighbors of endothelial cell function
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|
Neighbors of neuronal death
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Neighbors of cell growth
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|
Neighbors of ROS generation
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|
Neighbors of epithelial cell proliferation
|
|
Neighbors of cancer cell growth
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|
Neighbors of sensitization
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|
Neighbors of macrophage function
|
|
Neighbors of cellular immune response
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|
Neighbors of cellular senescence
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|
Neighbors of colony formation
|
|
Neighbors of macrophage differentiation
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|
Neighbors of cell differentiation
|
|
Neighbors of keratinocyte proliferation
|
|
Neighbors of stem cell migration
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|
Neighbors of life span
|
|
Neighbors of psoriasis
|
|
Neighbors of inflammatory disease
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|
Neighbors of rheumatoid arthritis
|
|
Neighbors of atherosclerosis
|
|
Neighbors of fibrosis
|
|
Neighbors of arthritis
|
|
Neighbors of injury
|
|
Neighbors of atherogenesis
|
|
Neighbors of vascular remodeling
|
|
Neighbors of metastasis
|
|
Neighbors of carcinogenesis
|
|
Neighbors of inflammation
|
|
Neighbors of tumor microenvironment
|
|
Neighbors of pathological angiogenesis
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|
Neighbors of obesity
|
|
Neighbors of vascular disease
|
|
Neighbors of diabetes mellitus
|
|
Neighbors of asthma
|
|
Neighbors of pneumonia
|
|
Neighbors of hyperplasia
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|
Neighbors of osteoarthritis
|
|
Neighbors of chronic obstructive pulmonary disease
|
|
Neighbors of reperfusion injury
|
|
Neighbors of airway inflammation
|
|
Neighbors of hepatitis
|
|
Neighbors of insulin resistance
|
|
Neighbors of infection
|
|
Neighbors of vascular injury
|
|
Neighbors of liver injury
|
|
Neighbors of neuroinflammation
|
|
Neighbors of sepsis
|
|
Neighbors of death
|
|
Neighbors of type 1 diabetes
|
|
Neighbors of autoimmune disease
|
|
Neighbors of ischemic stroke
|
|
Neighbors of dermatitis
|
|
Neighbors of neutrophil infiltration
|
|
Neighbors of heart disease
|
|
Neighbors of diabetic nephropathy
|
|
Neighbors of hepatocellular carcinoma
|
|
Neighbors of gastric cancer
|
|
Neighbors of colorectal cancer
|
|
Neighbors of cardiac remodeling
|
|
Neighbors of breast cancer
|
|
Neighbors of ischemia
|
|
Neighbors of systemic lupus erythematosus
|
|
Neighbors of melanoma
|
|
Neighbors of cartilage degeneration
|
|
Neighbors of interstitial fibrosis
|
|
Neighbors of neoplasm invasion
|
|
Neighbors of heart failure
|
|
Neighbors of lung disease
|
|
Neighbors of pulmonary fibrosis
|
|
Neighbors of cardiovascular disease
|
|
Neighbors of cancer
|
|
Neighbors of cerebral ischemia
|
|
Neighbors of neoplasm
|
|
Neighbors of neointima
|
|
Neighbors of atrophy
|
|
Neighbors of respiratory hypersensitivity
|
|
Neighbors of myocardial fibrosis
|
|
Neighbors of liver disease
|
|
Neighbors of prostate cancer
|
|
Neighbors of hypertrophy
|
|
Neighbors of ovarian cancer
|
|
Neighbors of pancreatic cancer
|
|
Neighbors of hypertension
|
|
Neighbors of intimal hyperplasia
|
|
Neighbors of kidney mesangial cell
|
|
Neighbors of osteoclast
|
|
Neighbors of T-cell
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Neighbors of lung
|
|
Neighbors of liver
|
|
Neighbors of skin
|
|
Neighbors of brain
|
|
Neighbors of nerve
|
|
Neighbors of NF-kB family
|
|
Neighbors of JNK
|
|
Neighbors of IL1 family
|
|
Neighbors of PPAR
|
|
Neighbors of Jun/Fos
|
|
Neighbors of NFKBI
|
|
Neighbors of PKC
|
|
Neighbors of PI3K
|
|
Neighbors of STAT family
|
|
Neighbors of mitogen-activated protein kinase
|
|
Neighbors of cytokine
|
|
Neighbors of interleukin
|
|
Neighbors of JAK
|
|
Neighbors of PDGF
|
|
Neighbors of Ras GTPase
|
|
Neighbors of ERK1/2
|
|
Neighbors of growth factor
|
|
Neighbors of PKA
|
|
Neighbors of LDL
|
|
Neighbors of NF-AT family
|
|
Neighbors of beta adrenoceptor
|
|
Neighbors of chorionic gonadotropin
|
|
Neighbors of IKBK
|
|
Neighbors of protein tyrosine kinase
|
|
Neighbors of NAD(P)H oxidase
|
|
Neighbors of SMAD subfamily
|
|
Neighbors of LXR
|
|
Neighbors of p38
|
|
Neighbors of estrogen receptor
|
|
Neighbors of T-cell receptor
|
|
Neighbors of histone deacetylase
|
|
Neighbors of PDGF-BB
|
|
Neighbors of HIF-1
|
|
Neighbors of GPCR
|
|
Neighbors of prostaglandin-endoperoxide synthase
|
|
Neighbors of aldehyde reductase
|
|
Neighbors of mitogen-activated protein kinase kinase
|
|
Neighbors of TSH
|
|
Neighbors of endothelin
|
|
Neighbors of proteasome endopeptidase complex
|
|
Neighbors of histone H3
|
|
Neighbors of alpha2 adrenoceptor
|
|
Neighbors of vitronectin receptor (integrin)
|
|
Neighbors of PP2A
|
|
Neighbors of SAPK
|
|
Neighbors of WNT
|
|
Neighbors of gonadotropins
|
|
Neighbors of immunoglobulin
|
|
Neighbors of PP2B
|
|
Neighbors of phospholipase
|
|
Neighbors of endostatins
|
|
Neighbors of FSH
|
|
Neighbors of TORC1
|
|
Neighbors of RA receptor
|
|
Neighbors of histone
|
|
Neighbors of Rho kinase
|
|
Neighbors of PDGF receptor
|
|
Neighbors of histone acetyltransferase
|
|
Neighbors of adrenoceptor
|
|
Neighbors of phosphodiesterase
|
|
sars-cov no binding
|
|
Figure 3_Mixed network of dexamethasone targets
|
|
Figure 3_Mixed network of dexamethasone targets
|
|
1_Inflammation in keratinocytes in the pathology of acne
|
|
2_Hyperseborrhea in acne vulgaris
|
|
2_Acute phase initiation in atopic dermatitis
|
|
2_Interleukin-17 and interleukin-22 signaling in psoriasis
|
|
1_TNF and IL1B provoke ECM degradation in osteoarthritis
|
|
1_Osteoclast-mediated bone resorption in postmenopausal women
|
|
2_Osteoblast-mediated bone demineralization
|
|
1_Osteoclast functional impairment in osteopetrosis
|
|
1_Formation of cysts in polycystic kidney disease
|
|
3_The role of interstitial fibroblasts in pyelonephritis
|
|
3_Mesangial cell dysfunction in glomerulonephritis
|
|
1_Local estrogen production stimulates ectopic endometrium proliferation
|
|
3_Enhanced angiogenesis in endometriosis
|
|
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
|
|
3_Endoplasmic reticulum stress in age-related macular degeneration
|
|
2_Pathogens stimulate mucins expression in the middle ear
|
|
2_Cardiomyocyte hypertrophy
|
|
3_Dysfunction of smooth muscle cells in hypertension
|
|
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
|
|
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
|
|
3_1_Mucus accumulation in asthma
|
|
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
|
|
4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
|
|
2_CD8+ T-cell response and mucosal damage in celiac disease
|
|
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
|
|
3_Human papilloma virus E4 and E5 proteins in viral reproduction
|
|
3_1_Beta-cell proliferation and compensation: proliferation
|
|
3_Islet beta-cell destruction in T1D
|
|
1_Microangiopathy in diabetic neuropathy
|
|
drug-target pairs binding
|
|
mapk1
|
|
New Pathway
|
|
Interleukin-17 and interleukin-22 signaling in psoriasis
|