Protein MTOR

URN urn:agi-llid:2475
Total Entities 0
Connectivity 17250
Name MTOR
Description mechanistic target of rapamycin (serine/threonine kinase)
Notes The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Longevity Related Drugs
Proteins with Altered Expression in Aging
Oncogene Induced Cellular Senescence
DNA Persistent Repair Inhibits mTOR Signaling
mTOR Signaling Activation by Fatty Acids and Glucose
mTOR Signaling Activation by Amino Acids
mTOR Signaling
mTOR Signaling Hyperfunction
Hypoxia Inhibits mTOR Signaling
SIRT1 Signaling in Aging
Autophagic-Lysosomal System Decline Associated with Aging
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
MTOR/TP53 Regulates Cell Metabolism
A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
Insulin Influence on Protein Synthesis
Insulin Signaling
Synaptic Potentiation by PKMZ in LTP Maintenance - Active State
SCF/FBXW7 Complex
SCF/BTRC Complex
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Myocardial Remodeling
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Cell Cycle Dysregulation in Melanoma
Melanoma
Proteins Involved in Melanoma
IL22 Induces Keratinocyte Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Proteins Involved in Diabetes Mellitus Type 2
Donohue Syndrome Progression (Hypothesis)
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Glucocorticoids in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Insulin Resistance in Hepatocytes
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Mass Regulation
beta-Cell Function Inhibition by Rapamycin (Rodent Model)
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
Proteins Involved in Obesity
Proteins Involved in Colorectal Neoplasms
Cetuximab Resistance in Colorectal Cancer
Peutz-Jeghers Syndrome
Acute Myeloid Leukemia
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Lymphoma, GCB Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TNF Receptor Associated Periodic Syndrome
Cowden Syndrome
Huntingtin Mutant Protein Toxicity Effects
Proteins Involved in Huntington Disease
Proteins Involved in Autistic Disorder and Aggression
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
Proteins Involved in Alzheimer's Disease
Proteins Involved in Epilepsy
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
mTOR Hyperactivation after Status Epilepticus
Glioblastoma, Primary
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Glioma
Neuroblastoma
ALK Associated Neuroblastoma
Sonic Hedgehog Signaling in Neuroblastoma
Proteins Involved in Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Genes with Mutations Associated with Hereditary Breast and/or Ovarian Cancer Syndrome
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
Proteins with Altered Expression in Ovarian Cancer
Proteins Involved in Primary Ovarian Insufficiency
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Androgen Receptor/Akt Signaling
Androgen Receptor and Cell Cycle in Prostate Cancer
Proteins Involved in Prostate Cancer
Androgen Receptor/SGK1 Signaling
Polycystins Mutation Effects in Cystic Kidney Disease
Proteins Involved in Polycystic Kidney Disease
AREG -> HIF1A Expression Targets
Noradrenaline/Gs Expression Targets
Epinephrine/Gs Expression Targets
EGF -> HIF1A Expression Targets
EGFR/ERBB2 -> HIF1A Signaling
EREG -> HIF1A Expression Target
HBEGF -> HIF1A Expression Targets
TAM Receptor Signaling Activation in Cancer
PI3K/AKT/MTOR Signaling Activation in Cancer
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
TGFB Signaling activation by Blocking of Tumor Suppressors
PI3K/AKT/MTOR Signaling Activation by Blocking of Tumor Suppressors
FBLN5 Potentiates Migration and Proliferation of Endothelial Cells in Cancer
HIF1A as Master Regulator of Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
MTOR/TORC in Cancer Cell Motility and Invasion
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Respiratory Chain Impairment in Cancer
Skeletal Muscle Wasting in Cancer Cachexia
Glutamine in Cancer Metabolism
Mutations in Krebs Cycle Enzymes in Cancer
IDO1 in Cancer Immune Escape
ICAM2 -> CTNNB/FOXO/STAT3 Signaling
NRG1 -> HIF1A Expression Target
Lysophosphatidic Acid/LPARs Signaling
Androgen Receptor non-Genomic Signaling
MERTK Signaling
TGF-beta Signaling
AMPK Signaling
AXL Receptor Tyrosine Kinase Signaling
mTOR Signaling
VEGF Signaling
EGFR Signaling
TGFA -> HIF1A Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
ace2
PPAR Psoriasis
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_Formation of cysts in polycystic kidney disease
3_Enhanced angiogenesis in endometriosis
2_Cardiomyocyte hypertrophy
2_Neuron and Schwann cell death
drug-target pairs direct regulation
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Ageing (Mammalian Animal Model)
Proteins Involved in Cowden Syndrome

MedScan ID 2475

LocusLink ID 2475
56717
56718

Alias RAFT1
FK506 binding protein 12-rapamycin associated protein II
mechanistic target of rapamycin (serine/threonine kinase)
target of rapamycin
FKBP12-rapamycin complex-associated protein
FK506 binding protein 12-rapamycin associated protein 2
FKBP12-rapamycin complex-associated protein 1
FKBP-rapamycin-associated protein FRAP
2610315D21
serine/threonine-protein kinase mTOR
rapamycin target protein
FK506 binding protein 12-rapamycin associated protein 1
AI327068
FKBP-rapamycin associated protein
RIKEN cDNA 2610315D21 gene
FKBP12-rapamycin complex-associated protein I
mTOR
mechanistic target of rapamycin
mammalian target of rapamycin kinase
MGC118056
FRAP/mTOR
RAPT1
FKBP12-rapamycin-associated protein
dj576k7.1
RP23-423L9.1
LOC230906
rapamycin and FKBP12 target-1 protein
flat-top protein
OTTMUSP00000011776
mTOR kinase
RAFT I
FK506-binding protein 12-rapamycin complex-associated protein 1
rapamycin associated protein frap2
FRAP_HUMAN
m-TOR
FRAP I
LOC277698
RAPT I
FRAP2
FKBP-rapamycin-associated protein
mechanistic target of rapamycin kinase
OTTHUMP00000001983
2610315D21Rik
FRAP1
mammalian target of rapamycin
FLJ44809
rapamycin target protein 1
2610315D21Rik(2)
SKS
FRAP
rapamycin and FKBP12 target 1
flat
FKBP-rapamycin associated protein (FRAP)
angiopoietin-like factor CDT6
TOR

EC Number 2.7.11.1
2.7.1.1

GO ID 0005524
0001030
0001031
0001032
0001156
0016301
0051219
0019904
0004672
0019901
0004674
0043022
0045182
0006207
0002296
0031929
0038202
0032148
0043276
0007420
0055013
0060048
0007569
0007050
0034198
0071230
0071456
0071233
1990253
0031669
0009267
0006112
0007281
0003007
0003179
0007616
0048255
0060135
0035264
0010507
0070885
0045792
1904193
1904213
0016242
0014736
0001933
0031397
0018105
0018107
0016310
0030838
0061051
1904056
1904690
0060999
1904000
0001938
0010718
0010628
0060252
1904197
0051549
0010592
0046889
0010831
1901216
0014042
0045429
0048714
0050731
0032516
0051897
0001934
1904058
1904206
0048661
0051496
0045945
1901838
0045727
1903691
0009791
0046777
0030163
0006468
0043087
0032956
0090335
0043610
0001558
0008361
1900034
0042752
0031998
0005979
1904059
0016241
0090559
0031641
0045670
0032095
0099547
0014823
0043200
0042220
0032868
0043278
0007584
0031667
0048511
0031529
0035176
0021510
0008542
0050882
0042060
0000139
0016605
0031931
0031932
0005737
0005829
0030425
0012505
0005789
0098978
0005765
0005764
0016020
0005741
0043025
0005654
0005634
0099524
0000166
0044877
0016740
0055006
0048738
0030030
0010942
0050769
0010976
0006109
0051896
0045859
0001932
0005794
0005783
0005739
0032991
0008144
0006281
0031295
0016049
0040007
0016236
0051534
0048015
0006950
0007165
0005942
0016773
0038095
0034605
0000724
0007173
0008543
0045087
0008286
0048011
0032314
0048010
0016772
0070438
0000082

KEGG ID hsa:2475
mmu:56717
rno:56718

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 4 78.76 cM

OMIM ID 601231
607341
616638

Rat chromosome position 5q36

Hugo ID 3942
HGNC:3942

Human chromosome position 1p36.22
1p36.2

Swiss-Prot Accession P42345
P42345.1
Q9JLN9
Q9JLN9.2
P42346
P42346.1
Q4LE76
Q5TER1
Q6LE87
Q96QG3
Q9Y4I3
Q2KHT0
Q811J5
Q9CST1
B4DZD5

PIR ID S45340
A54837

GenBank ID NC_000001
XR_001737087
XM_024446187
XP_024301955
NM_004958
NP_004949
XM_005263438
XP_005263495
XM_017000901
XP_016856390
XM_017000900
XP_016856389
XM_011541166
XP_011539468
XM_017000902
XP_016856391
NG_033239
AF152840
AJ300188
CAC15570
AL031291
AL049653
AL109811
AL359082
CAC42395
AL391561
CH471130
EAW71681
EAW71682
EAW71683
JB157964
CCW44092
KF495866
KJ399980
KT584057
AA725390
AB209995
BAE06077
AK126762
BAG54371
AK302863
BAG64047
AK304273
BAG65134
BC117166
AAI17167
BP250183
DC403129
L34075
AAA58486
L35478
AAC41713
U88966
AAC39933
P42345
NC_000070
NM_020009
NP_064393
XM_006539077
XP_006539140
NT_166299
AF350362
AAK38597
AL591032
AL713995
AL731654
CH466594
EDL14819
EDL14820
CU210865
AF152838
AAF73196
AK012031
BAB27985
AK036004
AK143381
AK158715
AK172584
BAE43081
BC021454
BC043920
AAH43920
BC112904
AAI12905
CJ130100
Q9JLN9
NC_005104
NM_019906
NP_063971
AC_000073
AABR07050447
AABR07050448
AAHX01040809
CH473968
EDL81121
FQ225126
L37085
AAA65929
U11681
AAA20091
P42346
XR_244786
NC_018912
AMYH02000283
AMYH02000284
AMYH02000285
AMYH02000286
AMYH02000287
AC_000026
AAHY01041929
AAHY01041930
XM_005263439
XP_005263496
AC_000133
ABBA01003042
ABBA01003043
ABBA01003044
ABBA01003045
XM_005263441
XP_005263498
XM_005263440
XP_005263497
AABR06040930

Swiss-Prot ID MTOR_HUMAN
MTOR_MOUSE
MTOR_RAT

Cell Localization Endoplasmic reticulum membrane
Golgi apparatus membrane
Mitochondrion outer membrane
Lysosome
Cytoplasm
Nucleus
PML body
Microsome membrane
Nucleus, PML body

Ensembl ID ENSG00000198793
ENSP00000354558.4
ENST00000361445.8
ENSMUSG00000028991
ENSMUSP00000099510.3
ENSMUST00000103221.9
ENSRNOG00000009615
ENSRNOP00000014167.4
ENSRNOT00000014167.7
ENSP00000354558
ENST00000361445
ENSMUSP00000099510
ENSMUST00000103221
ENSRNOP00000014167
ENSRNOT00000014167

MGI ID MGI:1928394
1332655
1928394

RGD ID 68371

Unigene ID Hs.338207
Mm.21158
Rn.11008

Homologene ID 3637

Shape Sickle-vertex