Protein IL10

URN urn:agi-llid:3586
Total Entities 0
Connectivity 12874
Name IL10
Description interleukin 10
Notes The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway Cortisol in Resolving Inflammation
Dectin-1 (CLEC7A) Signaling
DC-SIGN (CD209) Signaling
TLR4 Signaling in Leukocytes
Treg-Cell Differentiation
Th2-Cell Differentiation
AHR Signaling in Treg and Dendritic Cells Function
AHR Signaling in Th17 Cells Function
AHR Signaling in Tr1 Cells Function
MC1R in anti-Inflammatory Signaling
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
anti-Inflammatory Function of Macrophage M2 Lineage
Nociception Expression Targets Signaling
CCR1 Expression Targets
BDKRB1/2 -> Interleukins Production
CNR1/2 -> IL1B/2/4/6/10 Production
HRH2/4 -> IL6/10 Production
Leptin -> CD25/IL6/IL10 Production
P2RY11/13/14 -> IL8/10 Production
Proteins Involved in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Arterial Hypertension
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Proteins Involved in Acne Vulgaris
Genes with Mutations Associated with Atopic Dermatitis
Acute Phase in Atopic Dermatitis
Proteins Involved in Atopic Dermatitis
Atopic Dermatitis
Proteins Involved in Melanoma
Proteins Involved in Psoriasis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Proteins Involved in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Proteins Involved in Vitiligo
Genes with Mutations Associated with Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Proteins Involved in Diabetic Nephropathy
Proteins Involved in Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
Proteins Involved in Myasthenia Gravis
Proteins Involved in Obesity
Crohn's Disease
B-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Proteins Involved in Diffuse Large-B-Cell Lymphoma
Hodgkin and Reed-Sternberg Cells in Hodgkin Lymphoma
Proteins Involved in Hodgkin Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
Proteins Involved in Multiple Myeloma
Proteins Involved in Hepatocellular Carcinoma
Th2-Cell Response in Asthma
Proteins Involved in Gout
Proteins Involved in Osteoarthritis
Proteins Involved in Psoriatic Arthritis
Proteins Involved in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Proteins with Altered Expression in Systemic Scleroderma
Proteins Involved in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
Proteins Involved in Periodontitis
Gluten Impact on Neuronal System (Hypothesis)
Proteins Involved in Osteoporosis
Proteins Involved in Alzheimer's Disease
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Migraine
Proteins Involved in Parkinson's Disease
Proteins Involved in Multiple Sclerosis
Proteins Involved in Endometriosis
Proteins Involved in Spontaneous Abortion
Proteins Involved in Age-Related Macular Degeneration
IL10/STAT3 Signaling in M2 Macrophage and Retinal Angiogenesis
Proteins with Altered Expression in Age-Related Macular Degeneration
Proteins Involved in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
Elevated Receptors -> Expression Targets in Adipose Tissue
CD2 Expression Targets
CD19 Expression Targets
CD8 -> STAT Expression Targets
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Blood Vessel
CXCL12 Expression Targets
CCL3 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
Clozapine Induced Granulocytopenia
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> STAT Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
Elevated Receptors -> Expression Targets in Colon
Elevated Receptors -> Expression Targets in Appendix
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
IL12 Antitumor Effect is Blocked in Cancer
Proteins with Altered Expression in Tumor-Promoting Inflammation
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
Proteins with Altered Expression in Cancer Immune Escape
INHBA/ACVR2/BMPR Expression Targets
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IFNLR1-> STAT/NFKB Signaling
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
IL10R -> STAT Signaling
IL7 Expression Targets
IL15 Expression Targets
IL10 Expression Targets
IL2 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
PAF/Gq -> NF-kB Expression Targets
PGE1 Expression Targets
LDLR -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymph Node
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
CD40 -> Expression Targets in Thymus
CD40 -> Expression Targets in Lymph Node
C5AR1 -> Expression Targets in Lymphoid System and Blood
IgE Receptors -> Targets in Lymphoid System and Blood
Chemokine Receptor Family -> Expression Targets in Lymphoid System
Elevated Receptors -> Expression Targets in Thymus
NGF -> SMAD3/NF-kB Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
POMC Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
IFNA1/Gq Expression Targets
AGT -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
PDCD1 -> STAT Expression Targets
PDCD1 -> AP-1 Expression Targets
Collagen -> NF-kB Expression Targets
PAF Expression Targets
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> NFAT Expression Targets
TCR -> STAT Expression Targets
TGFB2-TGFBR1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB1-ACVRL1 Expression Targets
FASLG Expression Targets
CD40LG -> STAT Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TLR3 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR1 -> 2/6 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR9 Expression Targets
PPAR Psoriasis
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of renal hypertrophy
Neighbors of osteoclast number
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of carotid artery
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of allantois
Neighbors of alveolus
Neighbors of coronary artery
Neighbors of uterine cervix
Neighbors of vein
Neighbors of villus
Neighbors of bronchus
Neighbors of glands
Neighbors of nose
Neighbors of eye
Neighbors of cornea
Neighbors of hippocampus
Neighbors of lymph node of mesentery
Neighbors of mammary gland
Neighbors of ankle joint
Neighbors of vitreous body
Neighbors of thymus gland
Neighbors of cerebral cortex
Neighbors of myelin sheath
Neighbors of bladder
Neighbors of draining lymph node
Neighbors of nervous system
Neighbors of mesentery
Neighbors of nasopharynx
Neighbors of cervical lymph node group
Neighbors of periodontal ligament
Neighbors of salivary gland
Neighbors of corpus luteum of ovary
Neighbors of sympathetic nervous system
Neighbors of ileum
Neighbors of endocrine system
Neighbors of small intestine
Neighbors of aggregated lymphoid follicle of small intestine
Neighbors of mediastinal lymph node group
Neighbors of reproductive system
Neighbors of Fallopian tube
Neighbors of hypothalamus
Neighbors of choroid plexus
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of interleukin-35
Neighbors of endothelin
Neighbors of NOS
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of PP2B
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of TLR1/2 heterodimer
Neighbors of TORC1
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of histone acetyltransferase
Neighbors of adrenoceptor
Neighbors of phosphodiesterase
Model of PPARG signaling in psoriasis
dsRNA induces innate immunity and INFs in alveolar cells
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
Overview. Diseases of the skin (chapter 11)
Overview. Diseases of the digestive system (chapter 10)
Overview. Diseases of the ear (chapter 7)
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
3_Impairment of iron release from splenic macrophages
2_Defective tolerance of autoreactive T-cell in T1D
drug-target pairs direct regulation
drug-target moltransport
New Combined Pathway
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atopic Dermatitis
Genes with Mutations Associated with Psoriasis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Vitiligo
Genes with Mutations Associated with Inflammatory Bowel Diseases
Genes with Mutations Associated with Systemic Scleroderma
Genes with Mutations Associated with Multiple Sclerosis
Genes with Mutations Associated with Endometriosis

Source curated
GO component

MedScan ID 3586

LocusLink ID 3586
16153
25325
281246
553957

Alias IL10R ligands
IL10
IL10_HUMAN
IL10R ligand
IL10 receptor ligand
IL10A
CSIF
DRG-0229
interleukin IL10
AL513351.1
interleukin IL10A
Cytokine synthesis inhibitory factor
OTTMUSP00000017964
rhuIL-10
LOC113640
RP11-262N9.1
interleukin 10
MGC126451
T-cell growth inhibitory factor
interleukin IL10X
GVHDS
interleukin-10 receptor ligand
MGC126450
IL10X
T-cell growth inhibitory factor (TGIF)
interleukin IL10_HUMAN
TGIF
IL-10
interleukin-10
SCH 52000
Cytokine synthesis inhibitory factor
chromosome
scaffold

GO ID 0005125
0008083
0005141
0030183
0042100
0007568
0060670
0071392
0035729
0071222
0019221
0007253
0042742
0042832
0072577
0030097
0006954
0035722
0030595
0097421
0030889
0045347
0042130
0043066
0010507
0008285
0071650
0002875
0060302
0001818
0002740
2000352
0044130
0034115
1903208
0050728
0045355
0032689
0032692
0032695
0032701
0032715
0032717
0051045
0045930
0030886
0045019
1904057
0042536
0032720
1904706
0002904
0051091
0046427
0045348
0045787
0050715
0001938
0034116
0043032
1902895
1903672
0045893
1904707
0032800
1903659
0010468
0045191
1903034
0050807
0014823
0034465
0051384
0014854
0032868
0002237
0042092
0005576
0005615
0006955
0045944
0051930
0042493
0032496
0010033
0005622
0006916
0007267
0005737
0043193
0006950
0005515
0007260
0045077
0030236
0042095
0042221

KEGG ID hsa:3586
mmu:16153
rno:25325

MedLine Reference 10975994
11244051
11777537
11900340
11943322
12020953
12117955
12162438
12405978
12547408
12565791
12595497
12692173
12707357
12765335
1280414
14715528
15086467
15102771
15147725
15251379
15309723
15385469
15466015
15793858
16002150
16086233
16460340
16461369
16504995
16522370
16523426
16696964
16801669
16804000
16807647
16827395
16949747
17017555
17033197
17042978
17105443
1847510
8228801
8312229
8484757
8499633
9463379
10029084
10049699
10072260
10072487
10072503
10075984
10080539
10213266
10220502
10338525
10349636
10352288
10395689
10415042
10438933
10447769
10452990
10456884
10510089
10512928
10520755
10579119
10580272
10648462
10671193
10680745
10723680
10768980
10770288
10799901
10801266
10806208
10811896
10833484
10849019
10859210
10859330
10896769
10898750
10899905
10946317
10947805
10948132
11009441
11027433
11042159
11053501
11076861
11087155
11091273
11114383
11120869
11145695
11145720
11149562
11154238
11159016
11197687
11217851
11240949
11285204
11290761
11301049
11312256
11337387
11342656
11349033
11353686
11354274
11406467
11438376
11439163
11447117
11465103
11472326
11485976
11489951
11507020
11518689
11544198
11544344
11553589
11592059
11707574
11713466
11714812
11714822
11747355
11751938
11777988
11781183
11781285
11809742
11823481
11823525
11847480
11859129
11869683
11875494
11895333
11895981
11907098
11911827
11920565
11921420
11956064
11970958
11979045
11981816
11984528
11986256
12010973
12016137
12031039
12031983
12055222
12055591
12107190
12147624
12165544
12193690
12213197
12234058
12244307
12391013
12392966
12393933
12406350
12421951
12423305
12443720
12444141
12466851
12477932
12493739
12496393
12505044
12516547
12517950
12517967
12538658
12538682
12540559
12540780
12555667
12591228
12594061
12604029
12644245
12646621
12646644
12648490
12654856
12670447
12672053
12695566
12716449
12734362
12736147
12757625
12759407
12773301
12791309
12791311
12791312
12794151
12813366
12823276
12829028
12842419
12847222
12847269
12855551
12865418
12874231
12902846
12907458
12933825
12938214
12941137
12941477
12960338
12960341
12964046
1350294
13679317
1381512
14500669
14500676
14500760
14511232
14527170
14568011
14568953
14583235
14587096
14597556
14607897
14607938
14625477
14638805
14638808
14659593
14707076
14712288
14734716
14764687
14764735
14975940
14978122
14978125
15016857
15026134
15039316
15039389
15096489
15102048
15102820
15111500
15113757
15116295
15128834
15155614
15158910
1517575
15178562
15187140
15191815
15197230
15218058
15221959
15239105
15240669
15240692
15240714
15240716
15240748
15240754
15251981
15265879
15314695
15319439
15331352
15362035
15364107
15368285
15368446
15381187
15383460
15448706
15465816
15466252
15485815
15491348
15501390
15501460
15501755
15514019
15520859
15522916
15528374
15534372
15538945
15564479
15588938
15593122
15593124
15608148
15611254
15618456
15624697
15634884
15634927
15642955
15652291
15654818
15657087
15661876
15696103
15699124
15728505
15728512
15735429
15749884
15749903
15778345
15784551
15784555
15819696
15825073
15843536
15845473
15879082
15879134
15905543
15919371
15930318
15937545
15944323
15967820
15972681
16002688
16002704
16002724
16005735
16014616
16020505
16041410
16045731
16046470
16081806
16081807
16087867
16113316
16116213
16141072
16141073
16148099
16148101
16148158
16150927
16151533
16166328
16177068
16181351
16184516
16200070
16239532
16256304
16263172
16285949
16299306
16310049
16319715
16339566
16362885
16407368
16428751
16456026
16465591
16467201
16467202
16476050
16476058
16497487
16500554
16513385
16517715
16524889
16600195
16618605
16621988
16622000
16628253
16634801
16636014
16670770
16709607
16714569
16740391
16765924
16769814
16778140
16778988
16782435
16818788
16822852
16861635
16872378
16879997
16885377
16888018
16903779
16914507
16917957
16935932
16936808
16966495
16982822
17002586
17003481
17015698
17015721
17041596
17048272
17057220
17082624
17109466
17111348
17137799
17142729
17148671
17200193
2161559
2531194
7485382
7507352
7525726
7547677
7554464
7594497
7608550
7622047
7696210
7722286
7769128
7783752
7790826
7811281
7930605
7963574
7996051
8035532
8089491
8112615
8116046
8132775
8133052
8168140
8207233
8299735
8313907
8402911
8459215
8605933
8606382
8607899
8622125
8640871
8671667
8691138
8703029
8752931
8770874
8823360
8870704
8871628
8890206
8896500
8977282
8990348
9000540
9036973
9091582
9103224
9120288
9125545
9182682
9184696
9190113
9234781
9292893
9307269
9344502
9366429
9366559
9398398
9498745
9521054
9588906
9610731
9620592
9636366
9665272
9697983
9730890
9759845
9780204
9806746
9811341
9824514
9828225
9831707
9878080
9886396
9891477
9892616
9916075
9916727
9935167
9973435
10064624
10231374
10542212
10714547
10775602
10985253
11044099
11121048
1121048
11441115
11485736
11717514
11737614
11758730
11792123
11805149
11820460
11828010
11829538
11833470
11838849
11857058
11881827
11883743
11896938
11908705
11919157
11920312
11922883
11928840
11929132
11952921
11960393
11964134
11964300
11986609
11991675
11994432
12039409
12042661
12060853
12069178
12069391
12078789
12093676
12095128
12097418
12101075
12115622
12119553
12121678
12145682
12164877
12165551
12170266
12189567
12197884
12202153
12207099
12207325
12207353
12219016
12220553
12223518
12233881
12239181
12370394
12377950
12389080
12393426
12393603
12423294
12438341
12438348
12438424
12444143
12447749
12486603
12495723
12496396
12496489
12525572
12531774
12538698
12548511
12581488
12594817
12595905
12599058
12609526
12615834
12616343
12626585
12640314
12654092
12662377
12663757
12668613
12676754
12700072
12707018
12709682
12714267
12714269
12727335
12730860
12738388
12761561
12778475
12782719
12787424
12788307
12788980
12791310
12791313
12791314
12792880
12802400
12813360
12823999
12824008
12826153
12826369
12847677
12850811
12851716
12861049
12864989
12926133
12934185
12938145
12940515
12944981
12946990
12959221
12967650
13129651
14550257
14567558
14583474
14585195
14592815
14630401
14631168
14638775
14657427
14682393
14697935
14701701
14730222
14746814
14959851
14978075
14994383
14999688
15001471
15016829
15036247
15042002
15057267
15066699
15070757
15072702
15084933
15085177
15086488
15116066
15122773
15122797
15129234
15131577
15144570
15152368
15155645
15179129
15180472
15187110
15188059
15191519
15194284
15200436
15223612
15246967
15271933
15292362
15295621
15306847
15316224
15316663
15325405
15345120
15368517
15381182
15388260
15452323
15462469
15488737
15497451
15527169
15534100
15547296
15551142
15573087
15579372
15596839
15599664
15611648
15622443
15650893
15652446
15659329
15661939
15674653
15682481
15693804
15718915
15728515
15748779
15761493
15780075
15780879
15803357
15810889
15814696
15814743
15815689
15838798
15843082
15845862
15900488
15907845
15927856
15933064
15933743
15940038
15951665
15964392
15978325
15979955
15985167
15990800
16034145
16038043
16043753
16043989
16078336
16084491
16098562
16122836
16162776
16165702
16226734
16256199
16259956
16276011
16305644
16341266
16361810
16364177
16378687
16396704
16413199
16433832
16441483
16460885
16481285
16507146
16551363
16579847
16584395
16611358
16644716
16672419
16690414
16698276
16698426
16699450
16699452
16707559
16720211
16785496
16803619
16809636
16824070
16850164
16861661
16861684
16863661
16889540
16895750
16920714
16924108
16933851
16940525
16945026
16959027
16987066
17003778
17006334
17006724
17015714
17015751
17049666
17052299
17083041
17097497
17133531
17163451
17178344
17188628
2173142
7591871
7695626
7759550
8037735
8248239
8590020
8897595
8898665
8910398
9162098
9312047
9334723
9405662
9637497
9689103
9743208
11196656
11196718
11238636
11477472
12825869
15340161
15837194
16435103
16525502
16690518
16712948
16859503
16872712
16911685
16943796
16978071
17041236
17051272
17092253
17178764
17202341
17204399
17209781
17215862
17225142
17230494
17237407
17237722
17238853
17241871
17261758
17304105
17310845
17314689
17321603
17326156
17331973
17335372
17338374
17380193
17389013
17389235
17393023
17408400
17412916
17413867
17420099
17428673
17431682
17438520
17449476
17460178
17463301
17470530
17490670
17530721
17543146
17544674
17544800
17552041
17559576
17574964
17587429
17587715
17597660
17605296
17617027
17634568
17652887
17665434
17674321
17700165
17716608
7547951
7590988
7749063
8364028
8881045
9043871
9234486
9788463
10754317
10843696
11034365
11035098
11390498
11441071
11489988
11698492
11714756
12218136
12642601
12706496
12799032
15887111
16272349
16275384
16275759
16301610
16314435
16365149
16413748
16488621
16549598
17099102
17116728
17122368
17130251
17157804
17182557
17200198
17202367
17207783
17215490
17228359
17237385
17237391
17238832
17239241
17241399
17295069
17304625
17322422
17353283
17420232
17456802
17464085
17479109
17485448
17485459
17495050
17502388
17505142
17531383
17548634
17574631
17579057
17600128
17618911
17692287
17694059
9432975
9463404
9574553
9892605
17174526
17278885
17336456
17517520
15372997
16111147
16005068
16202237

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 1 56.89 cM
1 69.9 cM

OMIM ID 124092
614395
609423
180300

Rat chromosome position 13q13

Hugo ID 5962
HGNC:5962

Human chromosome position 1q32.1
1q31-q32

Swiss-Prot Accession P22301
Q6FGW4
P22301.1
P18893
Q3U879
P18893.2
P29456
P29456.1
Q0VBJ1
Q63263
Q6FGS9
Q6LBF4
Q71UZ1
Q9BXR7
IL10_HUMAN
IL10_MOUSE
IL10_RAT
Q6FGW4_HUMAN
Q0VBJ1_MOUSE

PIR ID A38580
A34853
JN0475

GenBank ID NC_000001
NM_000572
NP_000563
NG_012088
AB098711
AB261995
AB261996
AF083251
AF247603
AF247604
AF247605
AF247606
AF295024
AAK19173
AF418271
AAL06594
AL513315
CH471100
EAW93524
DQ217938
ABB01008
GQ405199
ACV30066
GQ847742
GQ847743
JN859070
JN859071
JN859072
JN859073
KT291742
U06844
U16720
AAA80104
U63015
X73536
CAA51942
X78437
CAA55201
Z30175
CAA82914
AF043333
AAC03534
AY029171
AAK38162
BC022315
BC104252
AAI04253
BC104253
AAI04254
CD369014
CR541993
CAG46790
CR542028
CAG46825
EU751618
ACE95684
EU751619
ACE95685
M57627
AAA63207
P22301
NC_000067
NM_010548
NP_034678
AL513351
CH466520
EDL39722
M84340
AAA39275
AK152344
BAE31139
BC120612
AAI20613
BC137844
AAI37845
M37897
AAA39274
P18893
NC_005112
XM_006249712
XP_006249774
XM_008769426
XP_008767648
NM_012854
NP_036986
AC_000081
AABR07020941
AAHX01075050
AAHX01075051
CH473958
EDM09836
L02926
AAA41425
X60675
CAA43090
P29456
AMYH02002554
XP_011507808
AAHY01010930
XM_011509506
CAH71813
AC_000023
AC_000133
NC_018912
AABR06074649
ABBA01010192
NT_167186
NW_926794
NW_001838536
AC_000044
Q6FGS9
Q6FGW4
Q6LBF4
Q71UZ1
Q9BXR7
NT_078297
NW_001030662
CAM14013
Q0VBJ1
Q3U879
NW_047394
NW_001084685
NT_021877
NT_039180
NW_000154
204904
266338
296621
111306698
123789355
123791017
124293
198289
198292
74214592
1041813
119613930
124292
13345058
13774080
14625940
15724398
186271
2905618
49456939
49457009
55665331
74355810
74355812
74709677
74717628
74723161
74724623
74748480
77702090
150439399
122889462
148707775
149058679
NT_086601
1170526
392825
AAA19011
NC_007314
NM_174088
NP_776513
NW_001493377
P43480
U00799
67079379
82194585
AAW78362
AY887900
CR848830
NC_007122
NM_001020785
NP_001018621
NW_001510630
Q5EFQ8
67459915
106880414
126003251
67459916
553957
Dr.135567
ZDB-GENE-051111-1
dre:553957

Swiss-Prot ID IL10_HUMAN
IL10_MOUSE
IL10_RAT
Q3U879_MOUSE
Q0VBJ1_MOUSE
Q6FGW4_HUMAN

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000136634
ENSP00000412237.1
ENST00000423557.1
ENSMUSG00000016529
ENSMUSP00000016673.5
ENSMUST00000016673.5
ENSRNOG00000004647
ENSRNOP00000006246.2
ENSRNOT00000006246.5
ENSMUST00000016673
ENSMUSP00000016673
ENSP00000412237
ENSRNOP00000006246
ENST00000423557
ENSRNOT00000006246

MGI ID MGI:96537
96537

RGD ID 2886

Unigene ID Rn.9868
Hs.193717
Mm.874
Bt.4723
Dr.135567

Homologene ID 478

Shape Rhomb

IPI ID IPI00026102
IPI00654087
IPI00326111
IPI00115602

Microarray ID 100319_at
AFFX-MurIL10_at

Homo sapiens Chromosome position 1q31-q32

Ensembl Transcript ID ENST00000367099

FunctionalClass cytokine
interleukin-10 receptor binding
protein binding
growth factor

Bos taurus Chromosome position 16

Mus musculus Chromosome position 1 69.9 cM

KEGG pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
T cell receptor signaling pathway

Rattus norvegicus Chromosome position 13q13

Ensembl Gene ID ENSG00000136634