Pathway
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Circadian Clock Genes Mutations Cause Insomnia
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Melatonin Effects on Circadian Cycle
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Hypoxia Inhibits mTOR Signaling
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High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
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GCG and PPY Regulate Metabolism and Satiety
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Ghrelin and Nesfatin-1 Regulate Stomach Functional State and Satiety
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mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
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Ghrelin and SST Regulate GH1 Release in Hypothalamus
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L-cell: GCG, PYY and 5-HT Release
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P-cell Activation
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K-cell: GIP Production
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I-cell: CCK-8 Secretion and Regulation of Eating Behavior
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D-cell: Somatostatin Release
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M-cell: Motilin Release
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A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
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G-cell: Gastrin Secretion
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ECL-cell: CHGA and Histamine Synthesis
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N-cell: Neurotensin Production
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Insulin Synthesis in beta-Cell
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Insulin Release Inhibition by Somatostatins
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Dopamine Receptors Signaling
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Serotonin Receptors Signaling
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Catecholamines Secretion from Adrenal Gland
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Circadian Clock and Sleep Regulation by Melatonin
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Norepinephrine Release Regulation
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Dopamine Mediated Glutamate Release/Uptake Circle in Neuron in Migraine
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Dopamine Synthesis and Release
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CRH Secretion Regulation
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Prolactin Production
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Somatostatin Receptors Signaling
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POMC Secretion in adenohypophysis
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Testicular AMH Production
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LH and FSH Signaling and Steroidogenesis
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Estrogens in Prolactin Production
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Steroid Hormones Steroidogenesis
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CXC Chemokine Receptor Signaling
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CC Chemokine Receptor Signaling
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Proplatelet Maturation
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Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
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MC1R in anti-Inflammatory Signaling
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Prostaglandin E2 Receptor Signaling in Neurons
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Leukotriene Effect on Vascular Endothelial Cell Response
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Eicosanoids in Myeloid Cell Activation
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Histamine Receptor H3 Signaling in Neurons
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Prostaglandin E2 and Histamine in Gastric Acid Secretion
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Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
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Basophil Activation
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Mast-Cell Activation without Degranulation through CRHR1 Signaling
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Mast-Cell Activation without Degranulation
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Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
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Neutrophil Chemotaxis
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SNS Related Adrenal Cortex Response
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Vascular Endothelial Cell Activation by NO
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Vasodilation Activation
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Vascular Endothelial Cell Activation by Cytokines
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Lipolysis Regulation in Adipocyte
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Synaptic Potentiation by PKMZ in LTP Maintenance - Active State
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Potassium Flux Regulation
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Nociception Expression Targets Signaling
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Sodium Flux Regulation
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Vascular Motility
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Ca2+ Flux Regulation
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TAAR1 -> Neurotransmitter Uptake
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NPY1R -> CRH/POMC Production
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CGRP -> Calcium Influx
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CRH -> Synthesis of Corticosteroids
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EDNRA/B -> Vascular Motility
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ADORA2A/B -> Vasodilation
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ADORA1/2A -> Exocytosis
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ADRB1/3 -> Vasodilation
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ADRA1 -> Ion Channels
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ADRA2C/ADRB2 -> Vasoconstriction
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ADRB1 -> Ion Channels
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ADRA2C/ADRB2 -> Synaptic Endocytosis
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ADRA2A -> Hyperpolarization
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ADRB1 -> Prostaglandin Generation
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BDKRB1/2 -> Vasodilation
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BDKRB1/2 -> Ion Channels
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CNR1/2 -> Membrane Transport
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CNR1/2 -> Vascular Motility
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CNR1/2 -> IL1B/2/4/6/10 Production
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DRD1/5 Expression Targets
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DRD2/4 -> Membrane Transport
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GALR1/2/3 -> POMC/NPY Production
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GALR1/2/3 -> Neurotransmitter Metabolism
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HRH1/2 -> Membrane Polarization
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HRH1/3 -> Synaptic Transmission
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HRH1/2 -> Vascular Motility
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HRH2/4 -> IL6/10 Production
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CHRM1/2/3/5 -> Ion Channels
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CHRM1/2/3 -> Vascular Motility
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OPRD/OPRM -> Ion Channels
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OPRK -> Pain Perception
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OPRL1 -> Ion Channels
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PTGIR -> IL6 Production
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PTGDR -> Vasodilation
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PTGER1/4 -> Vascular Motility
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PTGER2/3 -> Vascular Motility
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PTGIR -> Vasodilation
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HTR4/6/7 -> Vasodilation
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HTR7 -> IL6 Production
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HTR4/6/7 -> Cation Channels
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HTR2 -> Membrane Transport
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HTR1 -> Vascular Motility
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TACR1 -> Membrane Transport
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GABA(B)R -> Postsynaptic Inhibition
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GRM2-4/6-8 (Presynaptic) -> Glutamate Release Attenuation
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GRM1/5 (Postsynaptic) -> Ion Channels
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P2RY11/13/14 -> IL8/10 Production
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GPR3 in Oocyte Meiotic Arrest
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Agomelatine Antidepressant Action
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Histamine in Arousal Regulation
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Endocannabinoids Role in Sleep Regulation
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Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
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Prostaglandins Role in Sleep Regulation
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HRH3 in Negative Regulation of Histamine Production and Release in Sleep Regulation
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Adenosine Role in Sleep Regulation
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Retinal Ganglion and Suprachiasmatic Nucleus in Melatonin Synthesis Regulation
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Melatonin Synthesis in Pinealocytes
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non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
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Gap Junction Assembly
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beta-Cell Granules Exocytois
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Cardiomyocyte Dysfunction
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Dilated Cardiomyopathy
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Alcoholic Dilated Cardiomyopathy (Mouse Model)
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Ca2+ Signaling in Dilated Cardiomyopathy
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Angiotensin-Aldosterone System Activation Scheme
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Arterial Hypertension
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Endothelial Cell Dysfunction in Pulmonary Hypertension
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Vascular Reactivity in Raynaud Disease
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NO Synthesis in Early Vasospasm
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Contraction Due Vasospasm
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Sebocyte Proliferation in Acne Vulgaris
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Hyperseborrhea in Acne Vulgaris
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Melanoma
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MITF as a Regulator of Melanoma Cell Development
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Melanocyte Role in Skin Aging
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Wolfram Syndrome Progression (Hypothesis)
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Leptin in Insulin Synthesis and Secretion
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beta-Cell Destruction through Cytokines in Diabetes Mellitus
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beta-Cell Mass Regulation
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beta-Cell Recovery in Diabetes Mellitus
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G-Proteins Signaling in Insulin Secretion in beta-Cell
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beta-Cell Function Inhibition by Ciclosporine and Tacrolimus (Rodent Model)
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Ghrelin Influence on Insulin Secretion (Hypothesis)
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Ca2+ Reabsorption Decline in Intestine
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Ca2+/Pi Reabsorption Decline in Kidney in Hyperparathyroidism
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Hypothyrodism Associated Hyperprolactinemia
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DRD2 Pharmacological Inhibition in Hyperprolactinemia
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Ethanol Induced Efects in Hyperprolactinemia
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Cardiovascular Effects in Hyperthyroidism
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GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
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Ca2+/Pi Reabsorption Decline in Kidney in Hypoparathyroidism
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Osteoblast Dysfunction in Hypoparathyroidism
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Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
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Central Hypothyroidism
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Tertiary Hypothyroidism
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Prolactinoma Overiew
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Metastatic Colorectal Cancer
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Basophil Activation in Asthma
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CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
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Airway Epithelial Cell Dysfunction
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CFTR Expression in Epithelial Cells (Class I Mutations)
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CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
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Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
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Proteins Involved in Epilepsy
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ADK Expression Downregulation after Acute Seizures
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Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
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Vascular Endothelial Cell Vasodilation in Brain
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Nitroxyl and CGRP in Migraine Pain Activation
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Dopamine Synthesis and Release in Migraine
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Dopamine Mediated Glutamate Release and Glutamate Uptake Circle
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Vascular Smooth Muscle Cell Vasodilation in Brain
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eNOS (NOS3) Activation via Prostaglandin E2 and Histamine
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NO Effect on Vasodilation and Vasoconstriction
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GABRB3 Mutation and Adenosine Deaminase Polymorphism
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Sleep Disturbance (Hypothesis)
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Prostaglandin D2 Synthase Downregulation
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Local Estrogen Production in Endometriosis
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LH and FSH Signaling Impairment in Primary Ovarian Insufficiency
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MIF Role in Cholesteatoma
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Cholesteatoma
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HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
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Noradrenalin Signaling in Glaucoma
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Serotonin Signaling in the Ciliary Body
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Cochlear Hair Cell Synapse Proteins Mutations (Age-Related/Congenital)
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Polycystins Mutation Effects in Cystic Kidney Disease
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Penile Detumescense Augmentation Mechanisms
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Penile Erection Impairment
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Cryptorchidism Molecular Mechanism (Hypothesis)
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Sertoli Cells Dysfunction Causes Male Infertility
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Ions Reabsorption Dysregulation in Nephrolithiasis
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Ca2+ Reabsorption Dysregulation in Urolithiasis
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Noradrenaline/Gs Expression Targets
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Dopamine/Gs Expression Targets
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Serotonin/Gs Expression Targets
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Epinephrine/Gs Expression Targets
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GLP1R -> ARRB1 Signaling
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AGTR1 -> ARRB1/ARRB2 Signaling
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GPCRs Desentization
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Hedgehog Family -> ARRB1/ARRB2 Canonical Signaling
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CXCL6 Expression Targets
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CXCL1 Expression Targets
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CXCL2 Expression Targets
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CXCL3 Expression Targets
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CXCL5 Expression Targets
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Complement Component GPCRs Signaling
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Valdecoxib Induced Ischemic Disease
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Doxorubicin Induced Cardiotoxicity
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GCG Expression Targets
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ADCYAP1 Expression Targets
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FSHR Expression Targets
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Glutamate/Gq Expression Targets
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VIP Expression Targets
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HIF1A in Vasculogenic Mimicry of Cancer
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Myeloid Derived Suppressor Cells in Cancer Immune Escape
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Adenosine/cAMP Promote Immunosuppression by Treg Cells
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HCAR1/HCAR2 -> MAPK Signaling
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Thromboxane A2 Expression Targets
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PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
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Dronabinol/Anandamide Expression Targets
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S1P Expression Targets
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PGE1 Expression Targets
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MTNR1 Signaling
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Purine Metabolism
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OR1A1 -> GNAS Signaling
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AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
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AGT -> TP53 Expression Targets
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EDN1 Expression Targets
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AGT -> CREB Expression Targets
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SST Expression Targets
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NPY Expression Targets
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AGT -> ELK/SRF Expression Targets
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TAC1 Expression Targets
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EDN3 Expression Targets
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Lysophosphatidic Acid/LPARs Signaling
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Estrogens/ESR1 non-Genomic Signaling
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ERK/MAPK Canonical Signaling
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Hedgehog Family Signaling
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IL1B -> PGE2 Expression Targets
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ROS and RNS in Vasoconstriction and Vasodilation Regulation
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Model of PPARG signaling in psoriasis
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Model of PPARG related pathways in psoriasis (short version)
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3_Increased proliferation of sebocytes in acne vulgaris
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2_Hyperseborrhea in acne vulgaris
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1_Osteoclast-mediated bone resorption in postmenopausal women
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1_Formation of cysts in polycystic kidney disease
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1_Local estrogen production stimulates ectopic endometrium proliferation
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2_Impaired steroidogenesis in PCOS
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2_Dysfunctions of cochlear hair cell synapse proteins in hearing loss
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1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
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3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
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4_Endothelial cells repress vasoconstriction in hypertension
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3_1_Mucus accumulation in asthma
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4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
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4_Mucin hyperproduction in goblet and mucous cells in COPD
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1_Intestine epithelial cell dysfunction in ulcerative colitis
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3_1_Beta-cell proliferation and compensation: proliferation
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1_2_Insulin synthesis and secretion: insulin secretion
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1_1_Insulin synthesis and secretion: insulin processing and storage
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3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation
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1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
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3_Pain perception in diabetic neuropathy
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1_2_Glutamate overload and NO-mediated vasodilation
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1_Decreased secretion of thyroid hormones
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Model of PPARG signaling in psoriais (tested)
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