Protein RASGRF1

URN urn:agi-llid:5923
Total Entities 0
Connectivity 404
Name RASGRF1
Description Ras protein-specific guanine nucleotide-releasing factor 1
Notes The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
Primary Cell Localization Cytoplasm

Pathway Skin Aging
High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Catecholamines Secretion from Adrenal Gland
CRH Secretion Regulation
Prolactin Production
Thrombopoietin Receptors Signaling in Platelet Maturation
Mineralcorticoids Secretion Regulation
Plasmin Effects in Inflammation
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Leukotriene Effect on Vascular Endothelial Cell Response
Leukotriene Effect on Airway Smooth Muscle Response
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
CD16/CD14 Proinflammatory Monocyte Activation
anti-Inflammatory Function of Macrophage M2 Lineage
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Permeability Activation
Nociception Expression Targets Signaling
Vascular Motility
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA2C/ADRB2 -> Vasoconstriction
ADRA2C/ADRB2 -> Synaptic Endocytosis
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
HTR1 -> Vascular Motility
P2RY11/13/14 -> IL8/10 Production
Luteinizing Hormone in Oocyte Meiotic Resumption
G0/G1 Phase Transition
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Endothelin Signaling in Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Contraction Due Vasospasm
B-Cell Activation in Systemic Lupus Erythematosus
Vitiligo
Apoptosis of Melanocyte in Vitiligo
Proliferative Diabetic Retinopathy
G-Proteins Signaling in Insulin Secretion in beta-Cell
Olanzapine Effect on Insulin Secretion in Diabetes Mellitus
Ghrelin Influence on Insulin Secretion (Hypothesis)
RET1 Mutation in Hyperparathyroidism
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Prolactinoma Overiew
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Hodgkin Lymphoma
T-Cell Acute Lymphoblastic Leukemia
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Airway Smooth Muscle Cell Contraction
Mast-Cell Related Chemokines Signaling in Asthma
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Ovulation Block
FSH Action in Polycystic Ovary Syndrome
Dentin Formation Disruption
Proteins Involved in Epilepsy
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Vascular Smooth Muscle Cell Vasodilation in Brain
NO Effect on Vasodilation and Vasoconstriction
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
EGFR and PTAFR Signaling in Ovarian Cancer
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
VEGFA in Neovascular Glaucoma
PGF2-alpha Effect on Treatment
Cytokines Trigger Otitis Media
Muscarinic Receptor-Mediated Airway Smooth Muscle Contraction
Polycystins Mutation Effects in Cystic Kidney Disease
Plasmin Role in Glomerulonephritis
Sertoli Cells Dysfunction Causes Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
Complement Component GPCRs Signaling
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
G0/G1 Cell Cycle Phase Transition Activation in Cancer
VEGF Independent Angiogenesis in Cancer
CFL1 in Cancer Cell Motility
CD19 -> JUN/ELK Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL16 -> AP-1 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
PGE1 Expression Targets
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
Adenosine Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Ras-GRF Regulation Signaling
MERTK Signaling
AMPK Signaling
AXL Receptor Tyrosine Kinase Signaling
EGFR Signaling
HRAS Signaling
TCR -> AP-1 Expression Targets
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
ROS in Triggering Vascular Inflammation
ROS and RNS in Vasoconstriction and Vasodilation Regulation
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pathway 3
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
3_Enhanced angiogenesis in endometriosis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_2_Insulin synthesis and secretion: insulin secretion
1_1_Insulin synthesis and secretion: insulin processing and storage
3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation

Source curated
GO component

MedScan ID 5923
192213

LocusLink ID 5923
19417
192213
26449
9983
315877
785619
568885

Alias LOC315877
LOC145899
PP13187
Ras-specific nucleotide exchange factor CDC25
Rasgrf I
GRFbeta
GRF55
AI844718
guanine nucleotide-releasing factor, 55 kD
RASGRF1
Ras guanine release factor beta
Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
Ras protein-specific guanine nucleotide-releasing factor I
guanine nucleotide exchange factor (S. cerevisiae CDC25-related, son of sevenless-related)
guanine nucleotide releasing factor 1
CDC25Mm
P140 Ras-GRF
Ras guanine nucleotide-releasing factor 1
Ras-GRF1
Ras guanine nucleotide-releasing factor I
H-GRF55
Ras protein-specific guanine nucleotide-releasing factor 1
GNRP
GRF1
CDC25
CDC25L
guanine nucleotide exchange factor
guanine nucleotide-releasing factor 1
guanine nucleotide-releasing protein
ras-specific guanine nucleotide-releasing factor 1
p190
P190-A
p190RhoGEF
Ras-specific guanine nucleotide-releasing factor, homolog
cdc25 homolog
Guanine nucleotide releasing protein (GNRP) (P140 Ras-GRF)
GRF beta
p190Rho-GAP
p190Rho-GEF
guanine nucleotide exchange factor(S. cerevisiae CDC25-related, son of seve
guanine nucleotide exchange factor(S. cerevisiae CDC25-related, son of sevenless-related)
RAS guanyl releasing protein 3
Rasgrp3
Ras-specific nucleotide exchange factor CDC25
RAS guanyl releasing protein III
Guanine nucleotide releasing protein

GO ID 0005088
0005089
0035254
0005085
0000165
0090630
0008283
0007616
0031175
0043547
0046579
2000310
0035020
0046578
0035023
0048168
0048167
0034976
0007165
0007264
0005829
0030426
0043005
0005886
0017016
0008022
0019901
0030971
0035556
0048146
0097440
0016327
0016323
0005737
0043025
0005096
0071236
0032869
0001975
0005622
0032863
0032320
0007268
0051056
0005099
0005543
0006915
0048011
0008624
0019717
0050790
0023034
0005515
0007242

KEGG ID hsa:5923
mmu:19417
rno:192213

MedLine Reference 12024021
12477932
1379346
14749369
9933566
10349636
10455104
11042159
11076861
11172053
11217851
11640934
11749043
11753386
11909944
12095702
12466851
12496377
12740578
12805218
12925882
1376246
1379731
1396590
14676298
15029245
15513915
15629714
16141072
16141073
16236762
16314537
16325815
16407208
16467520
16513268
16723539
17028431
17030618
17075039
8088844
8246988
8293576
8299730
8782830
8889548
9045698
9384379
9501318
9570946
9602157
9603515
9872389
10220378
10681520
10918068
14702039
16855028
7637786
7684828
16969075
7828890
11500497
16921254
17114649
17135267
17141611
17321057

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 9 47.31 cM
9 50.0 cM

OMIM ID 606600

Rat chromosome position 8q31

Hugo ID 9875
HGNC:9875

Human chromosome position 15q25.1
15q24.2
15q24

Swiss-Prot Accession Q8IUU5
A8K270
Q13972
Q13972.2
Q9QZR7
B2RS27
P27671
P27671.2
P28818
Q5BJV1
P28818.1
F8VPA5
H0YKF2
J3KQP9
Q16027
Q71RC4
P70317
Q3UY04
Q9QYS5
Q8N849
GRP3_HUMAN
Q71UW1
RGRF1_MOUSE
A8K270_HUMAN
Q8IUU5_HUMAN
B2RS27_MOUSE
Q9QZR7_MOUSE

PIR ID A38985
S28407
S29083

GenBank ID NC_000015
XM_017022459
XP_016877948
XM_017022456
XP_016877945
XM_017022455
XP_016877944
XM_011521867
XP_011520169
NM_153815
NP_722522
NM_001145648
NP_001139120
NM_002891
NP_002882
XM_017022458
XP_016877947
XM_017022457
XP_016877946
XM_011521866
XP_011520168
AC011944
AC104231
CH471136
EAW99141
EAW99142
LS482415
SPT35792
AK092325
AK226101
AK290135
BAF82824
AK301205
BAH13432
AK309047
AL109674
AL109675
AL355696
AL359931
BC040275
AAH40275
DA126882
L26584
AAA58417
M91815
S62035
AAB26881
Q13972
NC_000075
XR_001778822
XM_006510875
XP_006510938
NM_011245
NP_035375
NM_001039655
NP_001034744
NM_001357743
NM_001357744
AC102545
AH008385
AAF08011
CH466560
EDL20898
EDL20899
U55232
AAB18907
AF169826
AAD55995
AK038936
AK079638
AK135070
BAE22409
AK140227
BAE24289
AK140380
AK162908
BAE37111
BC042449
BC138682
AAI38683
BC138683
AAI38684
CD775453
DV043084
L20899
AAA02741
M91816
X59868
CAA42525
P27671
NC_005107
NM_001105753
NP_001099223
NM_001170531
NP_001164002
AC_000076
AABR07071024
AABR07071025
AABR07071026
AABR07071027
AABR07071028
AAHX01056185
AAHX01056186
AAHX01056187
AAHX01056188
AAHX01056189
AAHX01056190
CH473954
EDL77567
EDL77568
AF044907
AAC25083
AF044908
AAC25084
BC091317
AAH91317
BF405809
CB583610
CB607130
CB713048
CB714920
X67241
CAA47666
P28818
XM_011521865
XP_011520167
XM_005254578
XP_005254635
XM_011521864
XP_011520166
XM_011521863
XP_011520165
XM_011521868
XP_011520170
XM_011521869
XP_011520171
NC_018926
AMYH02030874
AMYH02030875
AF370414
AAQ15250
XM_011242680
XP_011240982
AC_000031
AAHY01080404
AAHY01080405
AAHY01080406
AAHY01080407
AAHY01080408
XM_006720628
XP_006720691
XM_006720629
XP_006720692
XM_006720627
XP_006720690
AC_000147
ABBA01060598
ABBA01060599
ABBA01060600
ABBA01060601
ABBA01060602
ABBA01060603
XR_379405
NT_010194
NW_925907
NW_001838219
AC_000058
Q71RC4
Q8IUU5
NT_039476
NW_001030918
AF094687
AF094688
AF094690
AF094691
P70317
Q3UY04
Q9QYS5
Q9QZR7
Q8N849
AAH42449
Q8CFQ5
NW_000355
XM_236468
XP_236468
121515
3282806
3282808
57665
60688449
81864892
81909466
NW_001084876
NW_047800
Q5BJV1
Q71UW1
XM_001063727
XM_001063783
XP_001063727
XP_001063783
123792084
1669492
1708003
27503719
388247
50358
5917696
6424497
74148694
74149246
74187954
81861629
81869484
81900278
81907166
119619547
13124259
25955554
386047
433720
74729359
74759584
NT_086829
NC_007305
NW_001495267
XM_001253580
XP_001253581
NC_007124
NW_001510986
XM_692247
XP_697339
119619548
33341758
74712766
148688951
148688952
149018926
149018927

Swiss-Prot ID RGRF1_HUMAN
RGRF1_MOUSE
RGRF1_RAT
B2RS27_MOUSE
Q8IUU5_HUMAN
Q9QZR7_MOUSE
A8K270_HUMAN
Q5BJV1_RAT

Cell Localization Cytoplasm
Plasma membrane

Ensembl ID ENSG00000058335
ENSP00000452781.2
ENST00000558480.6
ENSP00000405963.3
ENST00000419573.7
ENSP00000378228.3
ENST00000394745.3
ENSMUSG00000032356
ENSMUSP00000034909.4
ENSMUST00000034909.10
ENSMUSP00000034912.4
ENSMUST00000034912.5
ENSRNOG00000014025
ENSRNOP00000070883.1
ENSRNOT00000082757.1
ENSP00000452781
ENST00000558480
ENSP00000405963
ENST00000419573
ENSP00000378228
ENST00000394745
ENSMUSP00000034909
ENSMUST00000034909
ENSMUSP00000034912
ENSMUST00000034912
ENSRNOP00000070883
ENSRNOT00000082757
ENSRNOP00000018794
ENSRNOT00000018794

MGI ID MGI:99694
99694

RGD ID 620395

Unigene ID Hs.459035
Mm.44561
Rn.135776
Rn.230019
Rn.230593
Hs.591111
Dr.117676
Rn.204769

Homologene ID 74972

IPI ID IPI00016784
IPI00171312
IPI00118835
IPI00795882
IPI00137899
IPI00435928
IPI00204771
IPI00199276
IPI00476106

Microarray ID 96313_at
215688_at

Homo sapiens Chromosome position 15q24

Ensembl Transcript ID ENST00000261752
ENST00000394745

FunctionalClass Ras guanyl-nucleotide exchange factor
guanyl-nucleotide exchange factor
Rho guanyl-nucleotide exchange factor
Ras GTPase activator
protein C-terminus binding

Bos taurus Chromosome position 7

Mus musculus Chromosome position 9 50.0 cM

KEGG pathway MAPK signaling pathway

Rattus norvegicus Chromosome position 8q31

Ensembl Gene ID ENSG00000058335

ProteinAtlas NormalTissue Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: cervix
uterine; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: islets of Langerhans; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: rectum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: skin; Cell type: epidermal cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: appendix; Cell type: lymphoid tissue; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: ovary; Cell type: ovarian stroma cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain