Protein IL13

URN urn:agi-llid:3596
Total Entities 0
Connectivity 5590
Name IL13
Description interleukin 13
Notes This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand

Pathway Immunoglobulin Class-Switch Recombination Activation
Immunoglobulin Genes Transcriptional Activation
T-Cell Maturation (Hypothesis)
Th2-Cell Differentiation
Lipoxins and Resolvins in Inflammation Resolution
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
anti-Inflammatory Function of Macrophage M2 Lineage
Proteins Involved in Atherosclerosis
Proteins Involved in Myocarditis
Mast-Cells Activation in Atopic Dermatitis
Genes with Mutations Associated with Atopic Dermatitis
Acute Phase in Atopic Dermatitis
Proteins Involved in Atopic Dermatitis
Atopic Dermatitis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Th2-Cell Function in Systemic Lupus Erythematosus
Proteins Involved in Diabetes Mellitus Type 1
B-Cell Activation in Crohn's Disease
Proteins Involved in Helicobacter Infections
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Diffuse Large-B-Cell Lymphoma
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
Proteins Involved in Hodgkin Lymphoma
Hodgkin Lymphoma
Hodgkin and Reed-Sternberg Cells Reprogramming
Proteins Involved in Pancreatic Cancer
ADAM33 Role in Asthma
Eosinophil Survival in Asthma
IL33 Signaling Related Eosinophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Periostin (POSTN) Production by Airway Epithelium in Asthma
IgE Induces Airway Smooth Muscle Cell Proliferation
Airway Smooth Muscle Cell Contraction
Goblet-Cell Exocytosis in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
B-Cell Mediated IgE Production in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Proteins with Altered Expression in Systemic Scleroderma
Proteins Involved in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
Genes with Mutations Associated with Psoriatic Arthritis
Proteins Involved in Glioblastoma
Proteins Involved in Glioma
Proteins Involved in Endometriosis
Genes with Mutations Associated with Asthma
Proteins with Altered Expression in Asthma
Proteins Involved in Chronic Obstructive Pulmonary Disease
Proteins Involved in Pulmonary Emphysema
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins Involved in Chronic Bronchitis
Proteins with Altered Expression in Cystic Fibrosis
Proteins Involved in Polycystic Kidney Disease
Epinephrine/Gs Expression Targets
Epinephrine/Gq Expression Targets
IL13/STAT6/ZEB1 Signalling Promotes Cancer Metastatic Progression
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
Proteins with Altered Expression in Cancer Immune Escape
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IL13R -> STAT6 Signaling
IL13R -> STAT Signaling
IL13 Expression Targets
IL3 Expression Targets
IL2 Expression Targets
LPA Expression Targets
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Thymus
Adenosine Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
TCR -> NFAT Expression Targets
TCR -> AP-1 Expression Targets
TLR4 -> AP-1 Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
PPAR Psoriasis
Model of PPARG signaling in psoriasis
Overview. Diseases of the respiratory (chapter 9)
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
drug-target moltransport
drug-target molsynthesis
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atopic Dermatitis
Genes with Mutations Associated with Psoriasis
Genes with Mutations Associated with Graves Disease
Genes with Mutations Associated with Asthma
Genes with Mutations in GWA Studies of Asthma
Genes with Mutations Associated with Psoriatic Arthritis
Genes with Mutations Associated with Systemic Scleroderma

Source curated
GO component

MedScan ID 3596

LocusLink ID 3596
16163
116553
281247

Alias interleukin IL-13 cytotoxin
T-cell activation protein P600
interleukin 13
IL13_HUMAN
interleukin IL13
NC30
IL-13 cytotoxin
RP23-239O19.1
interleukin-13 receptor ligand
IL13
IL XIIIs
OTTMUSP00000005816
interleukin IL13_HUMAN
MGC116789
MGC116786
IL XIII
interleukin IL XIII
interleukin IL XIIIs
MGC116788
LOC96500
P600
IL-13
interleukin-13
ALRH
BHR1
allergic rhinitis
Bronchial hyperresponsiveness-1 (bronchial asthma)

GO ID 0005125
0005144
0071260
0019221
0006955
0006954
0001774
0033861
1903660
2000352
1901247
1901215
0071635
0030890
0120162
0032723
0010628
0002639
1901251
0043032
0043306
2000231
0050714
0051281
0048661
0042531
0010155
0045471
0032496
0035094
0005737
0009897
0005576
0005615
0005126
0071345
0043270
0010469
0009612
0005623
0007267
0006928
0042526
0007165
0008284
0005625
0005515
0004871
0008283
0008009
0019735

KEGG ID hsa:3596
mmu:16163
rno:116553

MedLine Reference 10331006
12162438
12919086
15042582
15961726
16522370
7916615
10079098
10330435
10358179
10491413
10508526
10655497
10679097
10704283
10920230
10940898
10943842
10992460
10995789
11032397
11070175
11120785
11323701
11331286
11441116
11441125
11466392
11481612
11591797
11694459
11714822
11714828
11737071
11745342
11830478
11831873
11884467
11893731
12045241
12091879
12107190
12150887
12355446
12356575
12370375
12397019
12438750
12444158
12466851
12525563
12540780
12568496
12574343
12594274
12642602
12648490
12669034
12707030
12842850
12847266
12874364
12897202
12941477
14568929
14707083
14734772
14764728
14970180
15034018
15087305
15128831
15192232
15229217
15240714
15240716
15272080
15356151
15378055
15470039
15494506
15507491
15563687
15564479
15618138
15634931
15647285
15741272
15814686
15816016
15944273
15944318
16000330
16034131
16039582
16081840
16116211
16239566
16251181
16317093
16327802
16339553
16339565
16439363
16478801
16493031
16517724
16549365
16552085
16568498
16585593
16598817
16702603
16816360
16893457
16988272
17035062
17088137
17148674
2521353
7903102
7907877
8096327
8099936
8605347
8871614
9162077
9177770
9512421
9531306
9558109
9619371
9635196
9768762
9881967
9885919
9916716
9973388
10227975
10699178
10725748
10753117
11003391
11149986
11278629
11396683
11709756
11786536
11825773
11830476
11940068
12063528
12067309
12097410
12145428
12152987
12163193
12165514
12189139
12207328
12223527
12370393
12370400
12377947
12396617
12413765
12441140
12477932
12525574
12548511
12594065
12654630
12682264
12704784
12748293
12748907
12794003
12884288
12897746
12920029
12928861
12935900
1408833
14512310
14561191
14564352
14634100
14734771
14756548
14764428
14983029
14984938
15004182
15007352
15014952
15146247
15155567
15155645
15163701
15163899
15187156
15191916
15356556
15356573
15361241
15474066
15488706
15528258
15634905
15642470
15661077
15699166
15711639
15845862
15869882
15870068
15879126
15919378
15951665
16001979
16024972
16034134
16101942
16210662
16236836
16303333
16388492
16428771
16461126
16751012
16832637
16849505
16918506
16951338
16987060
17016624
17082655
17090525
17142763
17183946
7521694
7721105
8097324
8605348
9139718
9177784
9856949
9856950
10436181
10614495
10651852
11197307
11588017
16133987
17006604
17091279
17097743
17182591
17235327
17264150
17313976
17347445
17418380
17451413
17548690
17560640
17561245
17603012
17644317
7530359
10861042
12218103
12642601
16210602
16275384
16488622
16606668
17101709
17182558
17241396
17307869
17318894
17389581
17400600
17412309
17556359
17611223
17429054
17665443

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus
Bos taurus

Mouse chromosome position 11 31.98 cM
11 29.0 cM

OMIM ID 147683
607154
600807

Rat chromosome position 10q22

Hugo ID 5973
HGNC:5973

Human chromosome position 5q31.1
5q31

Swiss-Prot Accession P35225
P35225.2
P20109
P20109.1
P42203
P42203.1
O43644
Q4VB52
Q9UDC7
Q5SUZ9
Q4VB50
Q4VB51
Q4VB53

PIR ID I38060
E30552
I52290

GenBank ID NC_000005
NM_001354992
NP_001341921
NM_001354993
NP_001341922
NM_001354991
NP_001341920
NM_002188
NP_002179
NG_012090
AC004039
AC004041
AF172149
AF172150
AF193838
AF193839
AF193840
AF377331
AAK53823
AF416600
AY008331
AY008332
CH471062
EAW62324
EAW62325
EAW62326
EAW62327
HI573912
CBX47445
L13029
L42079
L42080
U10307
AAA83738
U31120
AAB01681
AF043334
AAC03535
BC096138
AAH96138
BC096139
AAH96139
BC096140
AAH96140
BC096141
AAH96141
L06801
AAA36107
X69079
CAA48823
CAA48824
P35225
NC_000077
NM_008355
NP_032381
AC005742
AL645741
CH466575
EDL33575
L13028
AA646049
M23504
AAA40149
P20109
NC_005109
NM_053828
NP_446280
AC_000078
AAHX01063901
AC107611
CH473948
EDM04394
L26913
AAA16478
P42203
NC_018916
AMYH02012219
AC_000033
AAHY01093363
BC152854
AAI52855
AC_000137
CAI24689
NT_034772
NW_001838952
NW_922784
AC_000048
Q4VB50
Q4VB51
Q4VB53
NT_096135
NW_001030461
Q5SUZ9
NW_047334
NW_001084656
Q4VB52
NT_039530
NT_086681
1170528
438876
129377
533247
56206964
81889541
1045452
1127548
116138167
121948508
14091716
186276
2905620
462408
580330
64653427
64654183
64654580
673420
74753700
74753701
74753702
4558814
5420145
7387804
AAD22748
AF072807
AF440369
AJ132441
CAB46636
NC_007305
NM_174089
NP_776514
NW_001495335
Q9XSV9
119582728
119582729
119582730
119582731
148701628
157170028
149052577
ABBA01068803

Swiss-Prot ID IL13_HUMAN
IL13_MOUSE
IL13_RAT
Q5SUZ9_MOUSE
Q4VB52_HUMAN

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000169194
ENSP00000304915.3
ENST00000304506.7
ENSMUSG00000020383
ENSMUSP00000020650.1
ENSMUST00000020650.1
ENSRNOG00000007652
ENSRNOP00000010121.1
ENSRNOT00000010121.2
ENSP00000304915
ENST00000304506
ENSMUSP00000020650
ENSMUST00000020650
ENSRNOP00000010121
ENSRNOT00000010121

MGI ID MGI:96541
96541

RGD ID 68949

Unigene ID Hs.845
Mm.1284
Rn.9921
Bt.12928

Homologene ID 1649

Shape Rhomb

IPI ID IPI00807607
IPI00116193
IPI00194737

Microarray ID 94168_at

Homo sapiens Chromosome position 5q31

Ensembl Transcript ID ENST00000304506

FunctionalClass signal transducer
cytokine
hematopoietin/interferon-class (D200-domain) cytokine receptor binding
interleukin-13 receptor binding
chemokine

Bos taurus Chromosome position 7

Mus musculus Chromosome position 11 29.0 cM

KEGG pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Fc epsilon RI signaling pathway

Rattus norvegicus Chromosome position 10q22

Ensembl Gene ID ENSG00000169194