Protein MAP3K1

URN urn:agi-llid:4214
Total Entities 0
Connectivity 1362
Name MAP3K1
Description mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Notes The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Osteoarthritis
Skin Aging
Melatonin Effects on Circadian Cycle
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thrombopoietin Receptors Signaling in Platelet Maturation
T-Cell Dependent B-Cell Activation
T-Cell Maturation (Hypothesis)
Th17-Cell Differentiation
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Scavenger Receptors in Platelet Activation
Bradykinin Effects in Inflammation
Toll-like Receptor Independent Sterile Inflammation
MC1R in anti-Inflammatory Signaling
Leukotriene Effect on Vascular Endothelial Cell Response
Leukotriene Effect on Airway Smooth Muscle Response
Basophil Activation
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Degranulation via FPR1 Signaling
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Growth Factors
Nociception Expression Targets Signaling
EDNRA/B -> Vascular Motility
ADRA1A -> IL6 Production
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
CHRM1 -> IL2 Production
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
IL1B Expression Targets -> Nociception
Melatonin in Cell Survival and Antioxidant Response
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Lymphocyte Mediated Myocardial Injury in Myocarditis
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
IL17 Signaling in Psoriasis
T-Cells Differentiation Block in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
Toll-like Receptors in beta-Cell
Proteins Involved in Diabetes Mellitus Type 2
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Insulin Resistance in Hepatocytes
beta-Cell Destruction through Cytokines in Diabetes Mellitus
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Hypoparathyroidism, Primary
CD4+T-Cell Response in Celiac Disease
OipA Signaling in Helicobacter Pylori Infection
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Follicular Lymphoma
Osteoclast Activation in Multiple Myeloma
Multiple Myeloma
Antiphospholipid Antibodies and Endothelial Cell Interaction
T-Cell Acute Lymphoblastic Leukemia
IL33 Signaling Related Eosinophilia in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Skin Fibrosis
Dentin Formation Disruption
CCR5 Signaling in Macrophages
Th17-Cell Numbers Reduction in HIV
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Osteoclast Activation in Postmenopause
Synaptic Exocytosis in Dementia
Glioma Invasion Signaling
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Microglia and Motor Neuron Interaction Dysregulation
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway
WNT Signaling in Breast Cancer
Angiogenesis in Endometriosis
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
VEGFA in Neovascular Glaucoma
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
WNT Signaling in Cystic Kidney Disease
Polycystins Mutation Effects in Cystic Kidney Disease
Plasmin Role in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> AP-1 Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
Frizzled Receptors -> ARRB1/ARRB2 non-Canonical Signaling
CD72 -> NF-kB Expression Targets
CD8 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD86 -> NFATC Expression Targets
Complement Component GPCRs Signaling
Clozapine Induced Granulocytopenia
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
FrizzledR -> JUN/PAX2 Signaling
ADCYAP1 Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
VEGFA Dependent Angiogenesis in Cancer
Inhibition of THBS1 Activates Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF2/MEF/MYOD Expression Targets
Insulin -> MEF/MYOD Expression Targets
AGER -> CREB/SP1 Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> MEF/MYOD/MYOG Signaling
FibronectinR -> NF-kB Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
IL16-> ATF/CREB/CREBBP Expression Target
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
MTNR1 Signaling
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
GNRH2 Expression Targets
EDN1 Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TNF-alpha/TNFRSF1A Signaling
JNK/MAPK Signaling
MERTK Signaling
Ras Signaling
TGF-beta Signaling
P38 MAPK/MAPK14 Signaling
AXL Receptor Tyrosine Kinase Signaling
PI3K/RAC1 Signaling
VEGF Signaling
EGFR Signaling
WNT Planar Cell Polarity (PCP) non-Canonical Signaling
ERK/MAPK Canonical Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
T-Cell Receptor -> ATF/CREB Signaling
TGFA -> TP53 Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF5/6 -> RB1/E2F Signaling
NGFR -> MEF Signaling
TNFRSF6 -> DDIT3 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> SPI1 Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
WNT1 Expression Targets
WNT3A Expression Targets
WNT4 Expression Targets
WNT5A Expression Targets
WNT7A Expression Targets
ace2
PPAR Psoriasis
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Formation of cysts in polycystic kidney disease
3_The role of interstitial fibroblasts in pyelonephritis
3_Enhanced angiogenesis in endometriosis
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Pathogens stimulate mucins expression in the middle ear
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_1_Polymorphisms associated with inflammatory bowel diseases
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
2_HIV - induced depletion of CD4+ T-cells
1_Microangiopathy in diabetic neuropathy
Model of PPARG signaling in psoriais (tested)
mapk1 protein modificators
Differentiation of psoriatic T cells
Interleukin-17 and interleukin-22 signaling in psoriasis

Source curated
ResNet
GO component

MedScan ID 4214

LocusLink ID 4214
26401
116667
100912399
17269
523962
564899

Alias SRXY6
MAPK/ERK kinase kinase I
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MEKK
OTTMUSP00000021865
LOC100912399
mitogen activated protein kinase kinase kinase 1
mitogen-activated protein kinase kinase kinase I
MAPKKK I
MEKK1
mitogen-activated protein kinase kinase kinase 1-like
OTTHUMP00000065818
Map3k I
Map3k1
MEK kinase 1
MAP kinase kinase kinase 1
MAPK/ERK kinase kinase 1
MAP/ERK kinase kinase 1
MAPKKK1
MEK kinase I
MAP/ERK kinase kinase I
MEK kinase
MEKK 1
mitogen-activated protein kinase kinase kinase 1
MAPK/ ERK kinase kinase I
MAPK/ ERK kinase kinase 1
MEKK I
scaffold
chromosome
similar to hCG40615
LOC564899

EC Number 2.7.11.25
2.7.1.-

GO ID 0005524
0004709
0004672
0019901
0004674
0008270
0038095
0000165
0002755
0000186
0032147
0071260
0006468
0023014
0031098
0005737
0005829
0008432
0004706
0008092
0016301
0046872
0051019
0031434
0000166
0046625
0016740
0004842
0007254
0007257
0008637
0043010
0003382
0061029
0002011
0016310
0030838
0030334
0007179
0042060
0030054
0005856
0031941
0016020
0007256
0032232
0018105
0043507
0043406
0043065
0045944
0050434
0046777
0051259
0000209
0006970
0006511
0007346
0004702
0006915
0042787
0008545
0030036
0045087
0035556
0034166
0034134
0034142
0034146
0034162
0038123
0038124
0002224
0016772
0016567
0005622
0008063
0034130
0004710
0010552
0005624
0008152
0007165
0042802
0000287
0007249
0005575
0005515
0008372
0001747
0000151

KEGG ID hsa:4214
rno:116667
mmu:26401

MedLine Reference 12941696
9808624
11784851
12011049
12049732
15037605
15164763
16006144
16427076
16491099
8643568
10349636
10465784
10523642
10805784
10852963
11042159
11076861
11217851
11756439
11782455
11891332
12048245
12122119
12458213
12466851
12493778
12584189
12839996
12878610
14500727
14586403
14967141
15001576
15358865
15558021
15601830
15607429
15795331
15882989
16141072
16141073
16557301
16568086
16760432
16761309
16887003
17101801
17143273
4035594
4724491
4865553
5630254
6740513
6883178
7618106
8385802
8597633
8621675
8637721
9427625
9924790
10611349
11746500
11815602
11903060
11971970
11971971
12079429
12185592
12228228
12456688
12600818
12763138
14612408
14743216
15205333
15299005
16044153
16046415
16286467
16434970
16636664
16714289
9008162
9689078
9836645
16344560
17301822
17397260
16081685
9078260

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio
Human

Mouse chromosome position 13 63.36 cM
13 60.0 cM

OMIM ID 600982
613762
OMIM:600982

Rat chromosome position 2q14
2

Hugo ID 6848
HGNC:6848

Human chromosome position 5q11.2

Swiss-Prot Accession Q13233
Q13233.4
F8VQ72
P53349.3
Q62925
Q62925.1
F1M778
P53349
M3K1_HUMAN
M3K1_RAT

PIR ID G01887
T10757

GenBank ID NC_000005
XR_001742068
NM_005921
NP_005912
XM_017009485
XP_016864974
XM_017009484
XP_016864973
NG_031884
AC008937
HF583845
CCQ43342
U29671
AAB05828
AA602425
AF042838
AAC97073
AK307828
BU194120
BX537527
DA889202
Q13233
NC_000079
NM_011945
NP_036075
XM_017315516
XP_017171005
XM_017315517
XP_017171006
AC118704
CH466568
EDL18419
EDL18420
U29669
U29670
AB014614
BAA85878
AF117340
AAD25049
AK142245
L13103
AAA97500
U23470
AAA85038
P53349
NC_005101
NM_053887
NP_446339
AC111653
CH473955
EDM10340
EDM10341
EDM10342
JQ013733
AFD32168
U48596
AAC52596
Q62925
XM_006231926
XP_006231988
AC_000070
XM_006224013
XP_006224075
AABR07008108
AAHX01013021
AAHX01013022
XM_011543407
XP_011541709
XM_011543408
XP_011541710
XM_011543406
XP_011541708
XM_005248519
XP_005248576
NC_018916
AMYH02011332
XM_006517664
XP_006517727
XM_011244663
XP_011242965
XM_011244664
XP_011242966
AC_000035
AAHY01110126
AAHY01110127
AAHY01110128
AAHY01110129
AAHY01110130
BC172631
AAI72631
XM_005248520
XP_005248577
AC_000137
ABBA01015768
XM_006517665
XP_006517728
XM_006517667
XP_006517730
XM_006517666
XP_006517729
XM_006231919
XP_006231981
XM_006231920
XP_006231982
AABR06012815
NT_006713
NW_922607
NW_001838934
AC_000048
NT_039590
NW_001030537
NW_001084795
NW_047620
XM_001074670
XP_001074670
XP_042066
AI317205
XM_042066
34854322
16758759
16758760
1354136
1354137
2499638
51767945
33859655
33859656
6141558
6141559
4583379
4583380
4032472
293729
293730
1143819
1143820
19860665
ENST00000264777
51465008
51464911
51464912
1002603
1002604
2815887
2815888
31873589
8488988
XM_001128827
XP_001128827
NC_007318
NW_001493936
XM_602275
XP_602275
NC_007123
NW_001510849
XM_688224
XP_693316
148887396
148686472
148686473
149059333
149059334
149059335

Swiss-Prot ID M3K1_HUMAN
M3K1_RAT

Cell Localization Membrane
Cytoplasm

Ensembl ID ENSG00000095015
ENSP00000382423.3
ENST00000399503.4
ENSMUSG00000021754
ENSMUSP00000104890.2
ENSMUST00000109267.8
ENSRNOG00000013177
ENSRNOP00000017968.3
ENSRNOT00000017968.3
ENSRNOG00000050275
ENSRNOP00000063470.3
ENSRNOT00000065473.4
ENST00000399503.3
ENSP00000382423
ENST00000399503
ENSMUSP00000104890
ENSMUST00000109267
ENSRNOP00000017968
ENSRNOT00000017968
ENSRNOP00000063470
ENSRNOT00000065473

MGI ID MGI:1346872
1346872
104845

RGD ID 620966
6487511

Unigene ID Rn.11081
Mm.15918
Hs.653654
Hs.657756
Hs.508461
Hs.170610
Hs.634810
Bt.65484
Dr.87896
Mm.446367

Homologene ID 8056

Shape Sickle-vertex

IPI ID IPI00210195
IPI00855985
IPI00130375
IPI00677379

Chromosome position 2q14
13 60.0 cM
5q11.2

Microarray ID 1368871_at
u48596_at
u48596_g_at
A_43_P12971
A_51_P402193
A_65_P05116
AF042838 >1
AF042838 >2
33009_at
214786_at
225927_at
2004_at
A_23_P41796
A_24_P766204
OR2370
OH5738A
ST079
MA256
RA0812
103020_s_at
103021_r_at
103022_at
243030_at

Homo sapiens Chromosome position 5q11.2

Ensembl Transcript ID ENST00000399503

ENSEMBL ENSG00000095015

FunctionalClass ATP binding
MAP kinase kinase kinase
identical protein binding
protein binding
kinase
magnesium ion binding
metal ion binding
nucleotide binding
protein kinase
protein serine/threonine kinase
transferase
zinc ion binding
ubiquitin-protein ligase
JUN kinase kinase

Hugo Symbol MAP3K1

Bos taurus Chromosome position 20

Mus musculus Chromosome position 13 60.0 cM

KEGG pathway GnRH signaling pathway
MAPK signaling pathway

Rattus norvegicus Chromosome position 2q14

Ensembl Gene ID ENSG00000095015

ProteinAtlas NormalTissue Tissue: lymph node; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: uterus
post-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: parathyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: glial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: lymphoid tissue; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: colon; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: vagina; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: islets of Langerhans; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: adrenal gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: breast; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in granular layer; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: duodenum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: epididymis; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: fallopian tube; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: gall bladder; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: heart muscle; Cell type: myocytes; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in glomeruli; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in tubules; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: bile duct cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: hepatocytes; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: macrophages; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: follicle cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: ovarian stroma cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: decidual cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: trophoblastic cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: prostate; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: rectum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: salivary gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: seminal vesicle; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: skeletal muscle; Cell type: myocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: small intestine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, lower; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: thyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: urinary bladder; Cell type: urothelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive