Protein CCL20

URN urn:agi-llid:6364
Total Entities 0
Connectivity 2291
Name CCL20
Description chemokine (C-C motif) ligand 20
Notes This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Primary Cell Localization Extracellular
Class Ligand

Pathway CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
Proteins Involved in Diabetic Nephropathy
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Helicobacter Infections
Proteins Involved in Ulcerative Colitis
Hodgkin and Reed-Sternberg Cells in Hodgkin Lymphoma
Hodgkin Lymphoma
Osteoclast Activation in Multiple Myeloma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Th17-Cell Differentiation in Asthma
Keratinocyte Activation in Psoriatic Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Neuroblastoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cytokines Trigger Otitis Media
T-Cell Cytotoxic Activation
Plasmin Role in Glomerulonephritis
HMGB1 Expression Targets
EGFR -> Expression Targets in Skin
DLL4 Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
IL1B Expression Targets
IL1A Expression Targets
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival time
Neighbors of functional recovery
Neighbors of therapeutic efficacy
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of bone mass
Neighbors of neutrophil count
Neighbors of viral load
Neighbors of vascular density
Neighbors of neurological outcome
Neighbors of recurrence rate
Neighbors of skin thickness
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival time
Neighbors of functional recovery
Neighbors of therapeutic efficacy
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of bone mass
Neighbors of neutrophil count
Neighbors of viral load
Neighbors of vascular density
Neighbors of neurological outcome
Neighbors of recurrence rate
Neighbors of skin thickness
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of cell adhesion
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of macrophage migration
Neighbors of neutrophil recruitment
Neighbors of cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of bone remodeling
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of monocyte adhesion
Neighbors of tumor immunity
Neighbors of neuroprotection
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of psoriasis
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of asthma
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of chronic obstructive pulmonary disease
Neighbors of leukocyte infiltration
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of melanoma
Neighbors of cartilage degeneration
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of liver disease
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of microglia
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mononuclear phagocyte
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of insulin-secreting cell
Neighbors of T-cell
Neighbors of mast cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of hematopoietic cell
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of lymphocyte
Neighbors of M2 macrophage
Neighbors of lung
Neighbors of liver
Neighbors of skin
Neighbors of intestine
Neighbors of airway
Neighbors of blood vessel
Neighbors of gastrointestinal tract
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of periodontium
Neighbors of brain
Neighbors of blood vessel wall
Neighbors of joint
Neighbors of lymphatic system
Neighbors of vagina
Neighbors of periodontal ligament
Neighbors of ileum
Neighbors of small intestine
Neighbors of NF-kB family
Neighbors of JNK
Neighbors of IL1 family
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of mitogen-activated protein kinase
Neighbors of TLR
Neighbors of cytokine
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of chorionic gonadotropin
Neighbors of protein tyrosine kinase
Neighbors of SMAD subfamily
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of IL12
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of mitogen-activated protein kinase kinase
Neighbors of non-coding RNA
Neighbors of PP2A
Neighbors of PP2B
Neighbors of ITG
Neighbors of CD3 complex
Neighbors of TORC1
Neighbors of phosphodiesterase
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
2_Interleukin-17 and interleukin-22 signaling in psoriasis
4_1_Polymorphisms associated with inflammatory bowel diseases
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 6364

LocusLink ID 6364
20297
29538

Alias C-C motif chemokine 20
CC chemokine ST38
MIP-3-alpha
chemokine CCL20
CCL20
CC chemokine LARC
OTTMUSP00000017966
CCL20 chemokine
MIP-3as
chemokine LARC
SCYA20
chemokine (C-C motif) ligand 20
CC chemokine MIP 3alpha
Beta chemokine exodus-1
Small inducible cytokine A20
LARC chemokine
OTTMUSP00000017965
MIP3A
ST38
exodus I
small inducible cytokine subfamily A (Cys-Cys), member 20
SY20_HUMAN
SY20
MIP-3[a]
exodus-1
CKb4
chemokine MIP 3alpha
LARC
C-C motif chemokine ligand 20
Liver and activation-regulated chemokine
macrophage inflammatory protein 3 alpha
Exodus
MIP-3a
small-inducible cytokine A20
beta-chemokine exodus-1
small inducible cytokine subfamily A20

GO ID 0048020
0031731
0008009
0007186
0072678
0035584
0060326
0007267
0071346
0071347
0071356
0070098
0006935
0019221
0042742
0006955
0006954
0048247
0002548
0030593
0070374
0043547
2000406
0007165
0072679
0005576
0005615
0005125
0050726
0051770
0002724
2000319
0071222
0071223
0071310
0010469
0042060
0042466

KEGG ID hsa:6364
mmu:20297
rno:29538

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 1 42.69 cM
1 52.0 cM

OMIM ID 601960

Rat chromosome position 9q34

Hugo ID 10619
HGNC:10619

Human chromosome position 2q36.3
2q33-q37

Swiss-Prot Accession P78556
P78556.1
O89093
Q642U4
Q54AI7
O89093.1
P97884
P97884.1
Q53S51
Q99664
Q9Z1X3
F8WHA7

GenBank ID NC_000002
NM_004591
NP_004582
NM_001130046
NP_001123518
AC073065
AAX93214
AY150053
AAN28940
CH471063
EAW70877
EAW70878
HI574034
CBX47506
BC020698
AAH20698
D17012
D86955
BAA13191
U64197
AAB61534
U77035
AAC50943
P78556
NC_000067
NM_016960
NP_058656
NM_001159738
NP_001153210
AB015137
BAA78113
AC123676
AJ007862
CAA07714
CH466629
EDL02154
EDL02155
EDL02156
AB015136
BAA76955
AF053313
AAC78295
AF099052
AAC78680
AJ222694
CAA10948
AK079862
BC028504
AAH28504
BX525886
BY026108
O89093
NC_005108
XM_006245164
XP_006245226
NM_019233
NP_062106
AC_000077
AABR07068189
AAHX01061198
CH474004
EDL75527
AF053312
AAC78294
U90447
AAB61459
P97884
NC_018913
AMYH02005926
DQ891973
ABM82899
DQ896841
ABM87840
XM_006496447
XP_006496510
XM_006496448
XP_006496511
AC_000023
AAHY01007985
AC_000134
NT_005403
NW_921618
NW_001838866
AC_000045
NT_039173
NW_001030684
Q54AI7
Q642U4
NW_001084884
NW_047816
ABBA01050170

Swiss-Prot ID CCL20_HUMAN
CCL20_MOUSE
CCL20_RAT
Q642U4_MOUSE
Q54AI7_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000115009
ENSP00000386273.3
ENST00000409189.7
ENSP00000351671.4
ENST00000358813.5
ENSMUSG00000026166
ENSMUSP00000139923.1
ENSMUST00000186832.1
ENSMUSP00000109064.2
ENSMUST00000113437.8
ENSRNOG00000015992
ENSRNOP00000021730.1
ENSRNOT00000021730.3
ENSP00000386273
ENST00000409189
ENSP00000351671
ENST00000358813
ENSMUSP00000139923
ENSMUST00000186832
ENSMUSP00000109064
ENSMUST00000113437
ENSMUSP00000027351
ENSMUST00000027351
ENSRNOP00000021730
ENSRNOT00000021730

MGI ID MGI:1329031
1329031

RGD ID 3646

Unigene ID Hs.75498
Mm.116739
Rn.10722

Homologene ID 3375

Shape Rhomb

IPI ID IPI00130917
IPI00221705
IPI00020355
IPI00216291
IPI00208858
IPI00750862