Protein FOXP3

URN urn:agi-llid:28953
Total Entities 0
Connectivity 3780
Name FOXP3
Description forkhead box P3
Notes The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway T-Cell Maturation (Hypothesis)
Treg-Cell Differentiation
AHR Signaling in Treg and Dendritic Cells Function
Kynurenine/AHR Signaling in Treg Cell Activation
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Melanoma
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Treg-Cell Function in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Neonatal Diabetes Mellitus
Proteins Involved in Celiac Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Autoimmune Polyglandular Syndromes Progression (Hypothesis)
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Proteins Involved in Endometriosis
Proteins Involved in Chronic Obstructive Pulmonary Disease
CD80 -> AP-1 Expression Targets
CD81 Expression Targets
Elevated Receptors -> Expression Targets in Colon
Elevated Receptors -> Expression Targets in Appendix
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
Adenosine/cAMP Promote Immunosuppression by Treg Cells
IL15 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
LDLR -> Expression Targets in Lymphoid System and Blood
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
NOTCH -> Expression Targets in Thymus
Elevated Receptors -> Expression Targets in Thymus
PDCD1 -> STAT Expression Targets
PDCD1 -> NFATC Expression Targets
PDCD1 -> AP-1 Expression Targets
TCR -> NFAT Expression Targets
TCR -> STAT Expression Targets
TGFB1-TGFBR1 Expression Targets
TGFB1-ACVRL1 Expression Targets
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
1_Differentiation of psoriatic T cells
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Defective tolerance of autoreactive T-cell in T1D
Model of PPARG signaling in psoriais (tested)
before laser treatment
Differentiation of psoriatic T cells
Anti-psoriatic drugs influence PPARG signaling
PPARG signaling after laser treatment

Group Genes with Mutations Associated with Diabetes Mellitus Type 1
Genes with Mutations Associated with Neonatal Diabetes Mellitus

MedScan ID 28953

LocusLink ID 28953
50943
20371
317382

Alias RP23-54C14.1
JM2 protein
OTTHUMP00000025832
XPID
FOXP3 transcription factor
RGD1562112
FOXP3delta7
scurfy
MGC141963
MGC141961
OTTHUMP00000025833
FOXP3
immunodeficiency, polyendocrinopathy, enteropathy, X-linked locus
Zinc finger protein JM2
PIDX
OTTMUSP00000017962
OTTMUSP00000017961
Scurfins
transcription factor FOXP3
forkhead box P3, scurfy
OTTMUSP00000017952
AIID
forkhead box P3
X-linked immunodeficiency, polyendocrinopathy, enteropathy gene
Scurfin
X-linked immune dysregulation, polyendocrinopathy, enteropathy gene
DIETER
JM2
IPEX
immune dysregulation, polyendocrinopathy, enteropathy, X-linked
immunodeficiency, polyendocrinopathy, enteropathy, X-linked
forkhead box protein P3
sf

GO ID 0003677
0003700
0000981
0051059
0051525
0000978
0035035
0042826
0046872
0042803
0043565
0003714
0001782
0002362
0042110
0043029
0002456
0050852
0006338
0001816
0002262
0032792
0043433
0032088
0002725
0042130
2000320
0046007
0008285
0002677
0042036
0050710
0035067
0031064
0050777
0045077
0032689
0032693
0032700
0045085
0032703
0032713
0032714
0032715
0048294
0000122
0045892
0032720
0032831
0002669
0035066
0033092
0032753
0002851
0045944
0045893
0032914
0002667
0030111
0048302
0045589
0006355
0009615
0002513
0005737
0005654
0005634
0032991
0003676
0002361
0010629
0050728
0050672
0002666
0010628
0045591
0002637
0006357
0002507
0045066
0005622
0006351
0003705
0001047
0043234
0009653
0030154
0006366
0008301
0003682
0003690
0046982
0008270
0043010
0021757
0021549
0021987
0009790
0040007
0048286
0007389
0060501
0002053
0009791
0021758
0060013
0007519
0048745
0042297
0005667

KEGG ID hsa:50943
mmu:20371
rno:317382

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position X 3.41 cM
X 2.1 cM

OMIM ID 300292
304790
222100

Rat chromosome position Xq12
Xq13

Hugo ID 6106
HGNC:6106

Human chromosome position Xp11.23

Swiss-Prot Accession Q9BZS1
B7ZLG1
Q9BZS1.1
Q53Z59
Q99JB6
Q99JB6.1
D3ZKI1
D4Q8I2
A5HJT1
B7ZLG0
B9UN80
O60827
Q14DD8
Q4ZH51

GenBank ID NC_000023
XM_006724533
XP_006724596
NM_014009
NP_054728
XM_017029567
XP_016885056
NM_001114377
NP_001107849
NG_007392
AC232271
AF235097
CH471224
EAW50671
EAW50672
EAW50673
GN344065
CAY55968
JA738833
CCF77062
JB259913
CDH61704
KP784358
KP784359
KP784360
KP784361
KP784362
KP784363
KP784364
KP784365
KP784366
KP784367
KP784368
KP784369
AF277993
AAG53607
AJ005891
CAA06748
AK292052
BAF84741
AK299988
BAG61809
BC113401
AAI13402
BC113403
AAI13404
BC143785
AAI43786
BC143786
AAI43787
BQ184335
DB342786
DQ010327
AAY27088
EF534714
ABQ15210
EU855812
ACJ46653
Q9BZS1
NC_000086
NM_001199347
NP_001186276
NM_054039
NP_473380
NM_001199348
NP_001186277
AF277994
AAG53608
AL672231
AL731793
CH466638
EDL33899
EDL33900
AB673115
AF277991
AAG53605
AF277992
AAG53606
AK157447
BAE34089
AK210240
AK212556
AK216372
AY357712
AAR11305
AY357713
AAR11306
BC132333
AAI32334
BC132335
AAI32336
DQ387959
ABD52722
KF471319
AHA56672
Q99JB6
NC_005120
NM_001108250
NP_001101720
XM_006256731
XP_006256793
AC_000089
AABR07073520
AAHX01109184
CH474078
EDL83847
EDL83848
AB232988
BAJ05810
AB232989
BAJ05811
AB232990
BAJ05812
XM_011543915
XP_011542217
XM_011543918
XP_011542220
XM_011543919
XP_011542221
XM_011543916
XP_011542218
XM_011543917
XP_011542219
NC_018934
AMYH02039324
BC111853
AAI11854
HQ258232
ADR82986
AC_000042
AAHY01206809
XM_005272611
XP_005272668
XM_005272610
XP_005272667
AC_000155
ABBA01046142
ABBA01046143
NW_004070880
CAM25950

Swiss-Prot ID FOXP3_HUMAN
FOXP3_MOUSE

Cell Localization Nucleus
Cytoplasm

Ensembl ID ENSG00000049768
ENSP00000365372.2
ENST00000376199.7
ENSP00000365380.4
ENST00000376207.9
ENSP00000396415.3
ENST00000455775.7
ENSP00000451208.1
ENST00000557224.6
ENSMUSG00000039521
ENSMUSP00000111405.1
ENSMUST00000115740.8
ENSMUSP00000111403.1
ENSMUST00000115738.7
ENSMUSP00000111404.1
ENSMUST00000115739.8
ENSRNOG00000011702
ENSRNOP00000015641.4
ENSRNOT00000015641.6
ENSRNOP00000073801.1
ENSRNOT00000077391.1
ENST00000376199.6
ENST00000557224.5
ENSMUST00000115739.7
ENST00000455775.6
ENST00000376207.8
ENSMUST00000115740.7
ENSP00000365372
ENST00000376199
ENSP00000365380
ENST00000376207
ENSP00000396415
ENST00000455775
ENSMUSP00000111405
ENSMUST00000115740
ENSMUSP00000111403
ENSMUST00000115738
ENSMUSP00000111404
ENSMUST00000115739
ENSRNOP00000015641
ENSRNOT00000015641
ENSRNOP00000073801
ENSRNOT00000077391

MGI ID MGI:1891436
1891436

RGD ID 1562112

Unigene ID Mm.182291
Mm.288192
Rn.177272
Hs.247700

Homologene ID 8516

Shape O-vertex

IPI ID IPI00115123
IPI00328094
IPI00604500
IPI00644203