Protein AHR

URN urn:agi-llid:196
Total Entities 0
Connectivity 4587
Name AHR
Description aryl hydrocarbon receptor
Notes The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway Longevity Related Drugs
AHR Signaling in Treg and Dendritic Cells Function
Kynurenine/AHR Signaling in Treg Cell Activation
AHR Signaling in Th17 Cells Function
AHR Signaling in Tr1 Cells Function
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
AHR Signaling in M1 Macrophages Function
Hematopoietic Cell Lineage: B-cell
Proteins Involved in Arterial Hypertension
Proteins Involved in Vitiligo
Proteins Involved in non-Alcoholic Fatty Liver Disease
Proteins Involved in Glioma
Proteins Involved in Endometriosis
Dioxin Role in Endometriosis
Aryl Hydrocarbon Receptor/Tryptophan Metabolites Signaling
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
Aryl Hydrocarbon Receptor/Arachidonic Acid Metabolites Signaling
Aryl Hydrocarbon Receptor/Heme-Derived Molecules Signaling
Ubiquitin Ligase Complex in Prostata Cell
Treg Cells Promote Immunosuppression in Cancer Immune Escape
IDO1 in Cancer Immune Escape
CD40 -> Expression Targets in Lymph Node
Chemokine Receptor Family -> Expression Targets in Lymphoid System
ER Stress (Unfolded Protein Response)
Oxidative Stress Protection via AHR-NFE2L2-NQO1 Signaling in Keratinocytes
Dioxin Induced Chloracne (Hypothesis)
B-Cell Differentiation Inhibition by Dioxin
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor promotion
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of ejection fraction
Neighbors of fasting plasma glucose
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of gastric cancer risk
Neighbors of fertility
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of metabolic response
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of mortality
Neighbors of survival rate
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor promotion
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of apoptosis rate
Neighbors of shear stress
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of tumor grade
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of ejection fraction
Neighbors of fasting plasma glucose
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of pregnancy outcome
Neighbors of gastric cancer risk
Neighbors of fertility
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of metabolic response
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of obesity
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of lung disease
Neighbors of cardiovascular disease
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of hepatocyte
Neighbors of mesenchymal stroma cell
Neighbors of stem cell
Neighbors of B-cell
Neighbors of T-cell
Neighbors of lung
Neighbors of liver
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of gastrointestinal tract
Neighbors of bone
Neighbors of ovary
Neighbors of breast
Neighbors of cardiovascular system
Neighbors of immune system
Neighbors of myelin sheath
Neighbors of nervous system
Neighbors of endocrine system
Neighbors of reproductive system
Neighbors of NF-kB family
Neighbors of IL1 family
Neighbors of Jun/Fos
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of TLR
Neighbors of interferon
Neighbors of PDGF
Neighbors of growth factor
Neighbors of PKA
Neighbors of chorionic gonadotropin
Neighbors of protein tyrosine kinase
Neighbors of SMAD subfamily
Neighbors of LXR
Neighbors of IL23
Neighbors of heat shock protein 90
Neighbors of proteasome endopeptidase complex
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of FSH
Neighbors of RA receptor
Neighbors of histone
Neighbors of PDGF receptor
Neighbors of phosphodiesterase
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
2_Defective tolerance of autoreactive T-cell in T1D
drug-target pairs direct regulation
drug-target molsynthesis

MedScan ID 196

LocusLink ID 196
11622
25690

Alias LOC193333
Ah receptor
dioxin receptor
Ah receptors
aromatic hydrocarbon receptor
AHR_HUMAN
class E basic helix-loop-helix protein 76
AhR
dioxin receptors
bHLHe76
aromatic hydrocarbon responsiveness
AHR2
aryl hydrocarbon receptors
Ahre
aryl hydrocarbon receptor
RP85
AH-receptor
Ah
In
Ahh

GO ID 0003677
0003700
0000981
0070888
0051879
0017025
0001094
0035326
0004879
0046982
0042803
1990837
0001223
0008134
0044212
0006915
0001568
0019933
0007049
1904613
0071320
1904322
0032922
0030522
0045892
0045944
0045893
0030888
0010468
0006357
0006355
0009636
0009410
0006366
0006805
0005737
0005829
0034752
0005654
0005634
0032991
0005667
0017162
0051087
0043565
0015643
0030183
0001782
0001922
0043029
0008015
0048514
0001974
0001569
0043010
0003214
0000902
1904682
0003243
0061009
0035162
0048732
0072102
0002376
0060993
0001889
0002260
2000279
0010693
1903170
0060547
0045668
0033689
0003085
0000122
0045906
0001541
0045899
0045793
0040010
0035166
0030850
0008217
0097746
0060420
0048608
0014070
0048511
0048745
0048536
0060841
0034751
0034753
0071385
0051726
0032355
0004874
0003705
0050880
0006950
0006351
0005730
0004871
0007165
0010843
0030528
0004872
0045927

KEGG ID hsa:196
mmu:11622
rno:25690

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 12 15.78 cM
12 18.0 cM

OMIM ID 600253

Rat chromosome position 6q16

Hugo ID 348
HGNC:348

Human chromosome position 7p21.1
7p15

Swiss-Prot Accession A0A024R9Z8
P35869
P35869.2
Q3U5D9
P30561
P30561.3
Q8R4S5.1
Q8R4S6.1
G3V6M2
P41738.2
A4D130
Q13728
Q13803
Q13804
Q8QZX6
Q8R4S3
Q99P79
Q9QVY1
Q8R4S5
Q8R4S6
P41738
O88930
O89105
Q3U2B1
Q6DLW6
Q6DLW7
Q6DLW8
Q6DLW9
Q6DLX0
Q6DLX1
Q6DLX2
Q6DLX3
Q6DLX4
Q6LEC9
Q683N8

PIR ID S59514
A46266
S58375

GenBank ID NC_000007
NM_001621
NP_001612
AC003075
AH003424
AAA92082
AAA92083
AAA92084
CH236948
EAL24281
CH471073
EAW93686
EAW93687
D31708
D38044
BAA07235
HF547963
CCO13674
LC377520
LC377521
LC377522
LC377523
LC377524
LC377525
LC377526
LC377527
LC377528
LC377529
LC377530
LC377531
LC377532
LC377533
LC377534
LC377535
U60524
AA329775
AK130815
AK307495
BC021696
BC069390
AAH69390
BC070080
AAH70080
BQ020427
BQ024331
BX505160
D16354
BAA03857
L19872
AAA16210
P35869
NC_000078
NM_001314027
NP_001300956
NM_013464
NP_038492
AC159635
AF325111
AAK13443
AH003146
CH466526
EDL36863
M94623
AAA02896
S76844
AAB33978
U50336
AF405560
AAL89725
AF405561
AAL89726
AF405562
AAL89727
AF405563
AAL89728
AF405565
AAL89730
AF405566
AAL89731
AF405567
AAL89732
AF405568
AAL89733
AF405570
AAL89735
AK014512
AK136072
AK153678
BAE32140
AK155380
BAE33231
AK171945
AK172436
AY662080
AAT75227
AY662081
AAT75228
AY662082
AAT75229
AY662083
AAT75230
AY662084
AAT75231
AY662085
AAT75232
AY662086
AAT75233
AY662087
AAT75234
AY662088
AAT75235
AY662089
AAT75236
AY662090
AAT75237
BC040248
D38416
P30561
Q8R4S5
Q8R4S6
NC_005105
XM_017594050
XP_017449539
NM_001308255
NP_001295184
NM_013149
NP_037281
NM_001308254
NP_001295183
NR_131776
NR_131775
AC_000074
AABR07063901
AAHX01043426
AAHX01043427
CH473947
EDM03301
EDM03302
EDM03303
EDM03304
AF082124
AAC35168
AF082125
AAC35169
AF082126
AAC35170
AJ821851
CAH25391
AM902281
CAP16657
AM902282
CAP16658
AM902283
CAP16659
AM902284
CAP16660
AM902285
CAP16661
AM902286
CAP16662
U09000
AAA56897
P41738
NC_018918
AMYH02015311
AC_000034
AAHY01099184
L19749
L19750
L19751
L19752
L19753
L19754
L19755
L19756
L19757
AAA72026
L19758
L19759
BC152973
AAI52974
BC156629
AAI56630
AC_000068
AC_000139
U28063
U28064
U28066
NT_079592
NT_007819
NW_001839003
NW_923240
AC_000050
NT_039548
NW_001030500
Q3U2B1
Q3U5D9
Q6DLW6
Q6DLW7
Q6DLW8
Q6DLW9
Q6DLX0
Q6DLX1
Q6DLX2
Q6DLX3
Q6DLX4
Q6LEC9
NW_001084845
NW_047760
Q683N8
ABBA01056640

Swiss-Prot ID AHR_HUMAN
AHR_MOUSE
AHR_RAT
Q3U5D9_MOUSE
A4D130_HUMAN

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000106546
ENSP00000242057.4
ENST00000242057.9
ENSMUSG00000019256
ENSMUSP00000112137.2
ENSMUST00000116436.8
ENSRNOG00000004342
ENSRNOP00000006618.5
ENSRNOT00000006618.7
ENSP00000242057
ENST00000242057
ENSMUSP00000112137
ENSMUST00000116436
ENSRNOP00000006618
ENSRNOT00000006618

MGI ID MGI:105043
105043

RGD ID 2074

Unigene ID Hs.171189
Mm.341377
Rn.91370

Homologene ID 1224

Shape O-vertex

IPI ID IPI00131277
IPI00231916
IPI00364957
IPI00021008
IPI00625415
IPI00890036