Pathway
|
Alzheimer's Disease
|
|
Osteoarthritis
|
|
Skin Aging
|
|
mTOR Signaling
|
|
mTOR Signaling Hyperfunction
|
|
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
|
|
Insulin Influence on Protein Synthesis
|
|
Insulin Influence on Glycogenesis
|
|
Dopamine Receptors Signaling
|
|
Serotonin Receptors Signaling
|
|
Catecholamines Secretion from Adrenal Gland
|
|
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
|
|
CRH Secretion Regulation
|
|
Prolactin Production
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
Mineralcorticoids Secretion Regulation
|
|
T-Cell Dependent B-Cell Activation
|
|
Natural Killer Cell Activation through C-Type Lectin-like Receptors
|
|
Natural Killer Cell Activation through ITAM-Containing Receptors
|
|
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
|
|
T-Cell Maturation (Hypothesis)
|
|
Natural Killer Cell Activation
|
|
CD8+ T-Cell Activation
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Plasmin Effects in Inflammation
|
|
Platelet Activation via Adhesion Molecules
|
|
Proplatelet Maturation
|
|
Platelet Activation via GPCR Signaling
|
|
Toll-like Receptor Independent Sterile Inflammation
|
|
MC1R in anti-Inflammatory Signaling
|
|
Leukotriene Effect on Airway Smooth Muscle Response
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
Macrophage M2-Related Phagocytosis
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
Neutrophil Recruitment and Priming
|
|
Neutrophil Degranulation via FPR1 Signaling
|
|
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
|
|
Neutrophil Chemotaxis
|
|
Negative Acute Phase Proteins Synthesis
|
|
Positive Acute Phase Proteins Synthesis
|
|
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Nociception Expression Targets Signaling
|
|
Vascular Motility
|
|
NPY1R -> CRH/POMC Production
|
|
NTSR1 Expression Targets
|
|
EDNRA/B -> Vascular Motility
|
|
ADRA1 -> Vasoconstriction
|
|
ADRA1A -> IL6 Production
|
|
ADRA2C/ADRB2 -> Vasoconstriction
|
|
ADRA2C/ADRB2 -> Synaptic Endocytosis
|
|
ADRA1 -> Prostaglandin Generation
|
|
BDKRB1/2 -> Prostaglandin Generation
|
|
CNR1/2 -> IL1B/2/4/6/10 Production
|
|
DRD2 Expression Targets
|
|
GALR1/2/3 -> POMC/NPY Production
|
|
HRH2/4 -> IL6/10 Production
|
|
CHRM1 -> IL2 Production
|
|
CHRM1/2/3 -> Vascular Motility
|
|
OPRK -> Pain Perception
|
|
PTGIR -> IL6 Production
|
|
PTGER1/4 -> Vascular Motility
|
|
HTR1 -> IL6 Production
|
|
HTR5 -> TNF Production
|
|
HTR1 -> Membrane Transport
|
|
IL6 Expression Targets -> Nociception
|
|
P2RY11/13/14 -> IL8/10 Production
|
|
Luteinizing Hormone in Oocyte Meiotic Resumption
|
|
Vitamine D Deficite and Dentin Formation
|
|
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
|
|
G0/G1 Phase Transition
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Endothelin Signaling in Arterial Hypertension
|
|
Aldosterone Synthesis Acute Regulation
|
|
Aldosterone Synthesis Chronic Regulation
|
|
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
|
|
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
|
|
Contraction Due Vasospasm
|
|
Sebocyte Proliferation in Acne Vulgaris
|
|
Inflammatory Reaction in Acne Vulgaris
|
|
Hair Follicle Keratinocyte Apoptosis
|
|
Androgens in Sebocyte Maturation
|
|
Atopic Dermatitis Onset
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
MITF as a Regulator of Melanoma Cell Development
|
|
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
|
|
IL22 Induces Keratinocyte Proliferation in Psoriasis
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Apoptosis of Melanocyte in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
CD8+ T-Cell Response to Self-Determinants in Diabetes
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Donohue Syndrome Progression (Hypothesis)
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Mesangial Cell Dysfunction in Diabetic Nephropathy
|
|
Proliferative Diabetic Retinopathy
|
|
Adiponectin Synthesis Declines in Insulin Resistance
|
|
Insulin Resistance in Hepatocytes
|
|
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
|
|
G-Proteins Signaling in Insulin Secretion in beta-Cell
|
|
Olanzapine Effect on Insulin Secretion in Diabetes Mellitus
|
|
Ghrelin Influence on Insulin Secretion (Hypothesis)
|
|
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
|
|
Hyperparathyroidism, Neonatal Severe
|
|
RET1 Mutation in Hyperparathyroidism
|
|
Hypothyrodism Associated Hyperprolactinemia
|
|
DRD2 Pharmacological Inhibition in Hyperprolactinemia
|
|
Ethanol Induced Efects in Hyperprolactinemia
|
|
Bone Remodeling in Hyperthyroidism
|
|
Cardiovascular Effects in Hyperthyroidism
|
|
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
|
|
CD4+T-Cell Response in Celiac Disease
|
|
CD8+ T-Cell Response in Celiac Disease
|
|
Celiac Disease
|
|
Metastatic Colorectal Cancer
|
|
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
RARA Signaling in Acute Myeloid Leukemia (M3)
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Proteins Involved in Chronic Myeloid Leukemia
|
|
Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Proteins Involved in Multiple Myeloma
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
TRPM7/8 in Pancreatic Adenocarcinoma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Goblet-Cell Related Mucus Secretion in Asthma
|
|
Basophil Activation in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Antigen-Presenting Cell Role in Asthma
|
|
Th2-Cell Response in Asthma
|
|
Mucin Production in Goblet Airway Epithelial Cells
|
|
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
|
|
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
|
|
Steroidogenesis Impairement in Polycystic Ovary Syndrome
|
|
Ovulation Block
|
|
Polycystic Ovary Syndrome
|
|
FSH Action in Polycystic Ovary Syndrome
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
Skin Fibrosis
|
|
Dentin Formation Disruption
|
|
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
|
|
CD4+ T-Cell Function Decline in HIV
|
|
CD4+ T-Cell Death in HIV
|
|
Estrogen Effects on Pregnancy Gingivitis
|
|
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
|
|
Cowden Syndrome
|
|
Gluten Impact on Neuronal System (Hypothesis)
|
|
Myostatin in Skeletal Muscles in Muscular Dystrophies
|
|
IL6 Promotes Inflammation in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
|
|
Osteoblast Function Decline in Osteoporosis
|
|
Proteins with Altered Expression in Rheumatoid Arthritis
|
|
APP and Glutamate Signaling Cause Neuronal Dysfunction in Alzheimer Disease
|
|
BDNF Upregulation Triggered by Seizures
|
|
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
|
|
Synaptic Exocytosis in Dementia
|
|
Glioblastoma, Primary
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Glioma Invasion Signaling
|
|
Ependymoma
|
|
Growth Factor Signaling in Neuroblastoma
|
|
Neuroblastoma
|
|
Microglia and Motor Neuron Interaction Dysregulation
|
|
ERBB/VEGFR/Akt Signaling in Breast Cancer
|
|
IGF1R/AKT Signaling in Breast Cancer
|
|
ESR1/ERBB Positive Luminal Breast Cancer
|
|
Breast Cancer
|
|
Angiogenesis in Endometriosis
|
|
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
|
|
Leptin Role in Endometriosis
|
|
MIF Role in Cholesteatoma
|
|
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
|
|
Cholesteatoma
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
Prostate Cancer
|
|
TRPM8 Effects in Prostate Cancer (Hypothesis)
|
|
Steroids Induced Cataract
|
|
VEGFA in Neovascular Glaucoma
|
|
CDKN2B-AS1 in Epigenetic Regulation of Glaucoma
|
|
Glutamate Mediated Excitotoxicity in Glaucoma
|
|
PGF2-alpha Effect on Treatment
|
|
Cytokines Trigger Otitis Media
|
|
Alveolar Macrophage Negative Regulation Declined in COPD
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Mucin Hyperproduction in Goblet and Mucous Cells
|
|
Polycystins Mutation Effects in Cystic Kidney Disease
|
|
Plasmin Role in Glomerulonephritis
|
|
Mesangial Cell Dysfunction in Glomerulonephritis
|
|
Interstitial Fibroblasts in Pyelonephritis
|
|
Sertoli Cells Dysfunction Causes Male Infertility
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
CD38 -> cADPR/Calcium Signaling
|
|
CD157 -> cADPR/Calcium Signaling
|
|
ANGPT1 -> CREB/CREBBP Expression Targets
|
|
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
|
|
AREG -> CREB/CREBBP Expression Targets
|
|
AREG -> NCOR2 Expression Targets
|
|
AREG -> SMAD1 Expression Target
|
|
AREG -> HIF1A Expression Targets
|
|
AREG -> AP-1 Expression Targets
|
|
Noradrenaline/Gs Expression Targets
|
|
Noreadrenaline/Gq Expression Targets
|
|
Epinephrine/Gs Expression Targets
|
|
Acetylcholine Expression Targets
|
|
Serotonin/Gq Expression Targets
|
|
Epinephrine/Gq Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
|
|
B-Cell Receptor -> AP-1 Signaling
|
|
BTC -> AP-1/ATF/CREB Expression Targets
|
|
BTC -> EP300/ETS/ETV/SP1 Expression Targets
|
|
SELE -> ELK-SRF Signaling
|
|
CD19 Expression Targets
|
|
CD81 -> AP-1 Expression Targets
|
|
CD247 Expression Targets
|
|
gamma Globulins Expression Targets
|
|
FCGR3A Expression Targets
|
|
CD19/CR2 Expression Targets
|
|
CD72 -> CREB/CREBBP Expression Targets
|
|
CD8 -> ATF/CREB/CREBBP Expression Targets
|
|
CD80 -> NF-kB Expression Targets
|
|
CD86 -> NF-kB Expression Targets
|
|
CXCL6 Expression Targets
|
|
CXCL1 Expression Targets
|
|
CXCL2 Expression Targets
|
|
CXCL3 Expression Targets
|
|
CXCL5 Expression Targets
|
|
Clozapine Induced Granulocytopenia
|
|
EGF -> HIF1A Expression Targets
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
EGF -> TP53 Expression Targets
|
|
EGF -> NCOR2 Expression Target
|
|
EGFR -> NCOR2 Signaling
|
|
EGFR/ERBB2 -> TP53 Signaling
|
|
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
|
|
EGFR -> SMAD1 Signaling
|
|
EGFR/ERBB2 -> HIF1A Signaling
|
|
EGFR -> AP-1/ATF2 Signaling
|
|
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
|
|
EREG -> CREB Expression Target
|
|
EREG -> EP300/SP1 Expression Targets
|
|
EREG -> HIF1A Expression Target
|
|
EREG -> AP-1/ATF Expression Targets
|
|
Erythropoietin -> AP-1/MYC/CREB Expression Targets
|
|
Erythropoietin -> ELK/SRF Expression Targets
|
|
PECAM1 Expression Targets
|
|
NCAM1 Expression Targets
|
|
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
FGF9 -> AP-1/CREB/MYC Expression Targets
|
|
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
FGF1 -> NCOR2 Expression Target
|
|
FGF7 -> RUNX Expression Targets
|
|
FGF8 -> AP-1/CREB/MYC Expression Targets
|
|
FGF1 -> RUNX Expression Targets
|
|
FGF18 -> AP-1/CREB Expression Targets
|
|
FGF23 -> NCOR2 Expression Targets
|
|
FGF8 -> RUNX Expression Targets
|
|
FGF9 -> RUNX Expression Targets
|
|
FGF2 -> NCOR2 Expression Targets
|
|
FGF4 -> AP-1/MYC Expression Targets
|
|
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> RUNX Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
FGFR -> RUNX2 Signaling
|
|
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
|
|
ADCYAP1 Expression Targets
|
|
FSHR Expression Targets
|
|
Glutamate/Gq Expression Targets
|
|
VIP Expression Targets
|
|
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
HBEGF -> AP-1/ATF Expression Targets
|
|
HBEGF -> TP53 Expression Targets
|
|
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
|
|
HBEGF -> HIF1A Expression Targets
|
|
HBEGF -> CREB/MYC Expression Targets
|
|
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
HGFR -> AP-1/CREB/MYC Signaling
|
|
TAM Receptor Signaling Activation in Cancer
|
|
G0/G1 Cell Cycle Phase Transition Activation in Cancer
|
|
TGFB Signaling activation by Blocking of Tumor Suppressors
|
|
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
|
|
Integrins in Cancer Cell Motility, Invasion and Survival
|
|
CDH2 Activation Promotes Cancer Cell Migration and Survival
|
|
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
IGF2 -> HIF1A/MYC Expression Targets
|
|
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
|
|
NCAM1 -> CREB/ELK/SRF/MYC Signaling
|
|
CD19 -> JUN/ELK Signaling
|
|
PECAM -> SP1 Signaling
|
|
FcIgER -> ELK-SRF Signaling
|
|
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
|
|
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
|
|
InsulinR -> ELK/SRF/SREBF Signaling
|
|
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
|
|
Fibronectin Expression Targets
|
|
CTGF -> AP-1/CREB/MYC Expression Targets
|
|
CTGF -> NCOR2 Expression Target
|
|
ICAM1 Expression Targets
|
|
IL6R -> CEBP/ELK/SRF Signaling
|
|
IL2R -> ELK/SRF/MYC Signaling
|
|
IL4R -> ELK/SRF/HMGY Signaling
|
|
IL16 -> AP-1 Expression Targets
|
|
IL6 Expression Targets
|
|
IL4 Expression Targets
|
|
IL2 Expression Targets
|
|
UrokinaseR -> ELK/SRF Signaling
|
|
PTPRC -> BCL6 Expression Targets
|
|
Leptin -> ELK/SRF Expression Targets
|
|
Prostaglandin F Expression Targets
|
|
Thromboxane A2 Expression Targets
|
|
LPA Expression Targets
|
|
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
|
|
Dronabinol/Anandamide Expression Targets
|
|
Morphine Expression Targets
|
|
PAF/Gq -> NF-kB Expression Targets
|
|
S1P Expression Targets
|
|
PGE1 Expression Targets
|
|
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
|
|
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
NRG1 -> TP53 Expression Target
|
|
NRG1 -> AP-1/ATF Expression Targets
|
|
NRG1 -> HIF1A Expression Target
|
|
NGF -> SMAD3/NF-kB Expression Targets
|
|
NGF -> AP-1/TP53/MYC Expression Targets
|
|
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
|
|
BDNF Expression Targets
|
|
NTF3 Expression Targets
|
|
NTF4 Expression Targets
|
|
NGF -> CREB/CEBPB/MEF2A Expression Targets
|
|
Adenosine Expression Targets
|
|
PDGFB -> AP-1/CREB/MYC Expression Target
|
|
PDGFC -> CREB Expression Target
|
|
PDGFD -> AP-1 Expression Targets
|
|
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
KIT -> MITF Signaling
|
|
PDGFR -> AP-1/MYC Signaling
|
|
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
GNRH1 Expression Targets
|
|
NTS Expression Targets
|
|
GAST Expression Targets in GAST Expression Targets
|
|
AGT -> TP53 Expression Targets
|
|
GNRH2 Expression Targets
|
|
OXT Expression Targets
|
|
POMC Expression Targets
|
|
CCL11 Expression Targets
|
|
EDN1 Expression Targets
|
|
AGT -> CREB Expression Targets
|
|
NPY Expression Targets
|
|
IFNA1/Gq Expression Targets
|
|
AGT -> ELK/SRF Expression Targets
|
|
TAC1 Expression Targets
|
|
EDN3 Expression Targets
|
|
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
|
|
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
|
|
PDCD1 -> AP-1 Expression Targets
|
|
PTPRC -> BCL6 Signaling
|
|
AngiopoietinR -> AP-1 Signaling
|
|
GDNF -> HSF1 Signaling
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
GAS6 -> AP-1/CREB Expression Targets
|
|
FIGF -> AP-1 Expression Target
|
|
FIGF -> NCOR2 Expression Target
|
|
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
GDNF -> HSF1 Expression Targets
|
|
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
|
|
Lysophosphatidic Acid/LPARs Signaling
|
|
Ras-GRF Regulation Signaling
|
|
Androgen Receptor non-Genomic Signaling
|
|
MERTK Signaling
|
|
Ras Signaling
|
|
TGF-beta Signaling
|
|
AMPK Signaling
|
|
Ras-GAP Regulation Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
PI3K/RAC1 Signaling
|
|
VEGF Signaling
|
|
EGFR Signaling
|
|
ERK/MAPK Canonical Signaling
|
|
TCR -> AP-1 Expression Targets
|
|
T-Cell Receptor -> AP-1 Signaling
|
|
TGFA -> TP53 Expression Targets
|
|
TGFA -> HIF1A Expression Targets
|
|
TGFA/AP-1/ATF Expression Targets
|
|
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
|
|
LTA Expression Targets
|
|
TNF -> AP-1 Expression Targets
|
|
TNF -> ELK-SRF Expression Targets
|
|
TNF -> CREB Expression Targets
|
|
TNF -> TP53/ATF Expression Targets
|
|
TNFRSF1A -> AP-1/ATF/TP53 Signaling
|
|
TNFRSF1A -> CREB/ELK-SRF Signaling
|
|
Thrombopoietin -> SPI1 Expression Targets
|
|
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
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Thrombopoietin -> SP1 Expression Targets
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IL1B -> NO Expression Targets
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ROS in Triggering Vascular Inflammation
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ROS and RNS in Vasoconstriction and Vasodilation Regulation
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ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
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PLAU -> ELK-SRF/AP-1 Expression Targets
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VEGFA -> ATF/CREB/ELK-SRF Expression Targets
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VEGFA -> NFATC Expression Targets
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VEGFC -> ATF Expression Target
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VEGFA -> AP-1/CREBBP/MYC Expression Targets
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VEGFA -> NCOR2 Expression Target
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VEGFR -> NFATC Signaling
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VEGFR -> AP-1/CREB/MYC Signaling
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VEGFR -> ATF/CREB/ELK-SRF Signaling
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pathway 3
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ace2
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prarg negative regulators, ps-positive
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Neighbors of Ras GTPase
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Model of PPARG signaling in psoriasis
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PPARG negative regulators and targets
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Model of PPARG related pathways in psoriasis (short version)
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non-proteinal partners of SARSs
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H2A-K120, H2A-K119 and H3-K4
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Epigenetic Modifications of H2A-K120, H2A-K119 and H3-K4
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1_Inflammation in keratinocytes in the pathology of acne
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2_Hyperseborrhea in acne vulgaris
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2_Acute phase initiation in atopic dermatitis
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2_Interleukin-17 and interleukin-22 signaling in psoriasis
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1_The onset of atopic dermatitis
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1_TNF and IL1B provoke ECM degradation in osteoarthritis
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2_Osteoblast-mediated bone demineralization
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3_The role of interstitial fibroblasts in pyelonephritis
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3_Enhanced angiogenesis in endometriosis
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1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
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2_Cardiomyocyte hypertrophy
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3_Dysfunction of smooth muscle cells in hypertension
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1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
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2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
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1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
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3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
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1_Th2 cell response in asthma
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3_1_Mucus accumulation in asthma
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2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
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4_Mucin hyperproduction in goblet and mucous cells in COPD
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1_CD4+ T cell and epithelial cell response in celiac disease
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2_CD8+ T-cell response and mucosal damage in celiac disease
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1_2_Insulin synthesis and secretion: insulin secretion
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1_1_Insulin synthesis and secretion: insulin processing and storage
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4_1_Insulin resistance: insulin signaling
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3_2_Beta-cell proliferation and compensation: neogenesis/dedifferentiation
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3_Islet beta-cell destruction in T1D
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2_1_General pathways of thyroid hormone signaling
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New Pathway
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HRAS->RAF->MAPK1/3
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KRAS->RAFs->MAPK1/3
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NRAS->RAFs->MAPK1/3
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Other RASs-RAFs-MAPK1/3
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Interleukin-17 and interleukin-22 signaling in psoriasis
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