Protein JAK2

URN urn:agi-llid:3717
Total Entities 0
Connectivity 16776
Name JAK2
Description Janus kinase 2
Notes This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Apoptosis of Cochlear Hair Cells (Noise-Induced, Mouse Model)
Leptin and CCK8 Activate Nodose Ganglia Neuron
P-cell Activation
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Serotonin Receptors Signaling
PRL and CSH Action in Mammary Gland
Thrombopoietin Receptors Signaling in Platelet Maturation
Immunoglobulin Genes Transcriptional Activation
Natural Killer Cell Activation
CD8+ T-Cell Activation
T-Cell Cytotoxic Mediated Cell Death
Th1-Cell Differentiation
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Proplatelet Maturation
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CXCR4 Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through KIT/F2R Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Prolactin Induced Dopamin Synthesis by TIDA Neurons (Negative Feedback)
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
IL6 Expression Targets -> Nociception
Leptin -> NO Production/Vasodilation
Leptin -> CD25/IL6/IL10 Production
CHRNA7 -> IL8 Production
G0/G1 Phase Transition
Th1-Cells Activation and Proliferation in Atherosclerosis
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Hair Follicle Keratinocyte Apoptosis
Atopic Dermatitis
Melanoma
Apoptosis Block in Melanoma Cell
T-Cells Differentiation Block in Psoriasis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Oxidative Stress in Vitiligo
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Toll-like Receptors in beta-Cell
Donohue Syndrome Progression (Hypothesis)
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Proliferative Diabetic Retinopathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Leptin in Insulin Synthesis and Secretion
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Mass Regulation
beta-Cell Destruction in Diabetes Mellitus Type 1
PTPRN/STAT5 in Insulin Synthesis in beta-Cell (Rodent Model)
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hashimoto's Thyroiditis
Thyroid Hormones in Adipose Tissue Metabolism
Thyroid Dysfunction
Graves Ophthalmopathy
KISS1 Production Impairment in Hypogonadotropic hypogonadism
Hypothyroidism, Secondary (Central)
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyrotropin Releasing Hormone (TRH) Hypothalamic Release in non-Autoimmune Hypothyroidism
Central Hypothyroidism
Tertiary Hypothyroidism
SOCS3 and PTPN1 in Hypothalamic Neuron Insensitivity to Insulin and Leptin
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
Metastatic Colorectal Cancer
B-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Proteins Involved in Acute Myeloid Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
B-Cell Acute Lymphoblastic Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Hodgkin and Reed-Sternberg Cells Reprogramming
Mantle Cell Lymphoma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in T-Cell Acute Lymphoblastic Leukemia
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
TRPM7/8 in Pancreatic Adenocarcinoma
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mast-Cell Related Chemokines Signaling in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Skin Fibrosis
CCR5 Signaling in Macrophages
Th17-Cell Numbers Reduction in HIV
CD4+ T-Cell Death in HIV
Diabetes Induced Periodontitis
Cowden Syndrome
IL6 Promotes Inflammation in Muscular Dystrophies
Bone Loss in Osteoporosis
BDNF Upregulation Triggered by Seizures
Glioma Stem Cell Program Activation
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Leptin Role in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
MIF Role in Cholesteatoma
IL6/JAK/STAT3 Signaling in Cholesteatoma
Cholesteatoma
Prostate Cancer
Proteins Involved in Prostate Cancer
TLR3 Role in Retinal Pigment Epithelial Cell
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Proteins Involved in Noise-Induced Hearing Loss
Cochlear Inflammation (Noise-Induced)
Cytokines Trigger Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Polycystins Mutation Effects in Cystic Kidney Disease
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
AREG -> STAT Expression Targets
Noreadrenaline/Gq Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
BTC -> STAT Expression Targets
IFNG -> ARRB1/STAT1 Signaling
CD22 -> STAT Expression Targets
CD72 -> NFATC Expression Targets
CD80 -> ATF/CREB/CREBBP Expression Targets
CD86 -> ATF/CREB/CREBBP Expression Targets
CLCF1 Expression Targets
CTF1 Expression Targets
CXCL12 Expression Targets
CCL3 Expression Targets
CCL3L1 Expression Target
CCL5 Expression Targets
CCL7 Expression Target
CCL7 Expression Targets
CCL8 Expression Targets
CCL15 Expression Targets
CCL2 Expression Targets
CCL4 Expression Targets
IL8 Expression Targets
CSF3 Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
CNTF Expression Targets
Clozapine Induced Granulocytopenia
EGF -> STAT Expression Targets
EGFR/ERBB -> STAT Signaling
EREG -> STAT Expression Targets
Erythropoietin -> FOXO3A Expression Targets
Erythropoietin -> NF-kB Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> STAT Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF2 -> STAT Expression Targets
FGF10 -> STAT Expression Targets
FGF18 -> STAT Expression Targets
FGF1 -> STAT Expression Targets
FGF9 -> STAT Expression Targets
FGF8 -> STAT Expression Targets
FGFR1 -> STAT Signaling
FGFR3 -> STAT Signaling
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH2/GHR Expression Target
GH1/GHR -> STAT Expression Targets
CSH1/GHR Expression Targets
CSH1/PRLR Expression Targets
GH1/PRLR Expression Targets
HBEGF -> STAT Expression Targets
HGF -> STAT Expression Targets
HGFR -> STAT Signaling
Receptors and Adaptor Proteins Activated in Cancer
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
G0/G1 Cell Cycle Phase Transition Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
IL12 Antitumor Effect is Blocked in Cancer
IL13/STAT6/ZEB1 Signalling Promotes Cancer Metastatic Progression
VEGFA Dependent Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Epithelial to Mesenchymal Transition in Cancer: Overview
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
IGF2 -> STAT Expression Targets
IGF1 -> STAT Expression Targets
Insulin -> STAT Expression Targets
InsulinR -> STAT Signaling
IGF1R -> STAT Signaling
IFNG/IFNR Expression Targets
IL31R -> STAT Signaling
IL6R -> CEBP/ELK/SRF Signaling
IL3R -> STAT Signaling
IL27R -> STAT Signaling
IL5R -> STAT Signaling
IL11R -> STAT3 Signaling
IL6R -> STAT Signaling
IL12R -> STAT Signaling
IL6ST -> STAT5B Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL12B Expression Targets
IL3 Expression Targets
IL6 Expression Targets
IL5 Expression Targets
IL11 Expression Targets
IL31 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Morphine Expression Targets
NRG1 -> STAT Expression Targets
OSM/OSMR Expression Targets
OSM/IL6ST/LIFR Expression Targets
PDGFC -> STAT Expression Target
PDGFD -> STAT Expression Targets
PDGF -> STAT Expression Targets
PDGFB -> STAT Expression Target
PDGFR -> STAT Signaling
CSF2 -> STAT Signaling
KIT -> STAT Signaling
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
POMC Expression Targets
CCL11 Expression Targets
AGT -> CREB Expression Targets
AVP/Gq -> STAT Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
AVP/Gs -> STAT Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
ProlactinR -> STAT Signaling
PDCD1 -> STAT Expression Targets
EphrinR -> STAT Signaling
CSF1 -> STAT Expression Targets
KITLG -> STAT Expression Targets
EphrinR Expression Targets
EFNA1 -> STAT Expression Target
PAF Expression Targets
FOXO1 Signaling
Ras-GAP Regulation Signaling
EGFR Signaling
T-Cell Receptor -> STAT Signaling
TGFA -> STAT Expression Targets
LTA Expression Targets
TNF -> STAT Expression Targets
TNFRSF1A -> STAT Signaling
Thrombopoietin -> STAT Expression Targets
ROS in Neutrophil Mediated Cell Damage
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
B-Cell Differentiation Inhibition by Dioxin
PPAR Psoriasis
Model of PPARG signaling in psoriasis
New Pathway (3)
H4 Modification Sites
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
1_Formation of cysts in polycystic kidney disease
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Cardiomyocyte hypertrophy
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Inflammatory mediators increase the production of hepcidin (HAMP)
5_The rationale for the treatment of anemia of chronic disease with erythropoietin
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
3_1_Beta-cell proliferation and compensation: proliferation
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
1_Decreased secretion of thyroid hormones
drug-target pairs binding
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Acute Myeloid Leukemia
Genes with Mutations Associated with B-Cell Acute Lymphoblastic Leukemia
Proteins Involved in B-Cell Acute Lymphoblastic Leukemia
Genes with Mutations Associated with Diffuse Large-B-Cell Lymphoma, PMBL Subtype
Genes with Mutations Associated with Hodgkin Lymphoma
Genes with Mutations Associated with T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Cowden Syndrome

MedScan ID 3717

LocusLink ID 3717
16452
24514
98155
107213

Alias OTTHUMP00000043260
THCYT3
Fd17
Janus kinase II
Jak2
Janus kinase 2 (a protein tyrosine kinase)
AI504024
Janus tyrosine kinase 2
C81284
Tyrosine-protein kinase JAK2
JAK2 kinase
JTK10
OTTHUMP00000021024
Janus kinase 2
JAK-2
C81284s
expressed sequence C81284
expressed sequence AI504024

EC Number 2.7.10.2
2.7.10.1
2.7.1.112

GO ID 0005524
0042169
0033130
0005131
0020037
0042393
0035401
0043560
0005143
0046872
0004715
0051428
0043548
0008022
0004672
0019901
0004713
0005102
0031702
0007186
0007259
0060397
0000165
0030041
0042976
0000186
0006919
0097296
0002250
0006915
0031103
0007596
0030154
0019221
0007167
0030218
0097191
0060396
0035409
0060333
0035722
0038155
0070106
0070757
0070102
0035556
0008631
0061180
0007498
0001774
0031959
0050804
0043392
0010667
0008285
0022408
0045822
0043524
0018108
0048008
0043388
0051091
0045348
0046579
0050867
0045597
0030335
0010811
0120162
0007204
1904037
1902728
0060399
0050729
0032024
0050725
0045429
0051770
0050731
0014068
0032516
0010870
0042535
0032760
0042531
1904707
0099527
0046777
0006468
0046425
0050727
0060334
0045428
0046677
0033194
0070671
0032496
0034612
0007165
0033209
0007260
0005901
0005737
0005856
0005829
0031904
0005925
0098978
0045121
0016363
0005654
0005634
0005886
0098794
0016301
0000166
0016740
0071549
0036016
0071222
0006325
0009755
0034050
0002376
0045087
0030099
0043066
0060548
0016310
0043065
2001235
0008284
0032731
0045944
0035166
0097012
0006979
0016020
0012505
0033160
0042981
0005088
0030155
0005622
0006954
0031234
0016477
0007243
0005515
0038083
0043547
0042977
0006928
0016568
0042503
0042506
0042508
0016772
0042517
0007262
0042523
0042127
0043526
0005624
0008636
0051773
0004718
0023034
0004674
0000074
0007242

KEGG ID hsa:3717
mmu:16452
rno:24514

MedLine Reference 12817007
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16269269
16847321
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16887119
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14522994
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11360203
15522878
17012261
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10899310
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16034466
11799081
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10205168
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1281307
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10872831
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12147240
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12426001
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15121872
15860661
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16632470
15530849
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15958724
16871275
12106016
12686512
12478664
9510175
15604419
11373296
11114734
15988755
7530656
15354294
8876196
15256805
12244095
9632636
11694501
14978237
12107179
7543024
11591716
12488507
11881154
10747872
9553131
9670957
11971965
9126968
15815685
16247455
15169911
12441334
8657151
16025117
11698276
10725249
9624169
10757801
16478879
15985214
11294897
9355737
8611693
14678947
14551204
12777386
9618263
15676212
17105449
16929538
10635327
16926301
16084028
8034026
15591245
16804112
15716400
12540842
12223098
10954736
9590174
9590173
10922068
16873677
15677497
14759523
10064597
15358195
14996842
7746328
10842184
8617237
12594853
8918879
15932931
9484840
9326218
12960006
11042159
8343951
7607555
8593242
16091753
16079889
10531356
11413148
15790774
1581631
7540178
15688010
15615703
8063772
16204151
10872802
16923108
16280321
15701573
10781830
15688008
8063815
16514419
2466296
10925297
16849644
12007403
16868251
16420986
11313464
12244045
8378315
11163768
9162069
16728702
10506573
11839738
12637327
7889566
7544789
9473212
15863514
11944994
7500025
11818507
15322111
16620973
10842319
17078929
15322115
2482828
16932338
9689060
12584205
8912646
14998905
10026141
15007095
16365288
10979953
7534285
9344848
9446644
15065871
16442619
10455176
9548458
16990780
8208550
12691918
16257269
9133424
9573010
15666812
16757685
9111318
16772604
10374907
7535773
9492017
16567515
8609418
9452495
15102475
11585385
9119818
8943354
16257270
10551884
14500680
10224114
16987804
12921784
9575217
12456798
16084495
1620548
7925280
11430697
10586060
12393730
16141073
17057021
8662243
16141072
12370296
9169451
12595539
16572200
15781101
16990759
16934228
11593427
15793561
17024180
9012831
10502458
11779507
10200816
9889194
7613027
15292206
16502590
17128263
12952963
17249502
7690989
11134016
15923602
12023981
17077140
8702385
11934902
15143188
15837627
11923474
15143187
7542761
12748279
16497804
12777975
15985544
7775438
9363897
11679576
15746188
9727029
7657660
12023369
10938266
12920237
16982687
16705160
12552091
7812050
16831057
15611059
15159394
8756581
7499280
12538627
16598312
12477932
10349636
11731619
9516124
16959875
12668872
9837922
11087817
15156153
10918587
12576423
10421843
16598306
10772872
16603627
10931824
15899943
16434490
12941779
9202126
11152457
16597920
8995399
10692450
9342212
11350938
15198092
12551917
16885051
12393587
11875116
7559603
8934548
15659221
16877349
7514165
16914724
15164053
15805263
16424865
16537803
16769584
16904848
16954506
17045648
17052978
17068151
17110452
17111143
17151700
17169814
17190855
17198871
17229651
17229652
17237409
17263783
17267906
17296581
17296594
17315023
17344916
17356406
17363731
17376889
17389152
17403204
17408106
17426257
17439832
17440984
17443220
17460706
17476275
17488346
17509995
17596137
17613428
17625156
17689208
12388746
12704203
16563502
17317861
17519353
17543594
8022486
11064147
11244571
17021051
17332060
17496209
17526654

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 19 23.73 cM
19 24.0 cM

OMIM ID 147796
601626
600880
133100
254450
263300
614521
187950

Rat chromosome position 1q52
1q51-q53

Hugo ID 6192
HGNC:6192

Human chromosome position 9p24.1
9p24

Swiss-Prot Accession O60674
A8K910
B4DYV1
O60674.2
G5E852
Q62120
Q62120.2
Q62689
Q62689.1
O14636
O75297
Q62124
Q7TQD0
Q506Q0
Q52R86
Q8IXP2
Q8CIN8
O35804
JAK2_RAT
JAK2_HUMAN
JAK2_MOUSE

PIR ID JW0091
A47511
B39577
JH0114
JC4127

GenBank ID NC_000009
NM_001322194
NP_001309123
NM_001322195
NP_001309124
NM_001322198
NP_001309127
NM_001322196
NP_001309125
NM_001322199
NP_001309128
NM_004972
NP_004963
NM_001322204
NP_001309133
NG_009904
AL158147
AL161450
AL513350
AY973037
AAY16348
CH471071
EAW58774
EF094945
ABK91947
EF194100
ABM69254
EU272048
ABX71217
KT584046
AF001362
AAC23653
AF005216
AAB82092
AF058925
AAC23982
AI923337
AK292525
BAF85214
AK302618
BAG63863
AK308668
AY973034
AAY22962
BC039695
AAH39695
BC043187
O60674
NC_000085
XM_006526713
XP_006526776
XM_006526715
XP_006526778
NM_008413
NP_032439
NM_001048177
NP_001041642
XM_011247155
XP_011245457
XM_017318068
XP_017173557
XM_006526714
XP_006526777
AC119228
AC162456
AY157991
AAN62560
AY785782
CH466534
EDL41674
AA756436
AK087255
BC054807
AAH54807
BC059834
AAH59834
BE981299
BF019856
BF730796
BG068603
CD363707
CJ046359
CJ056249
L16956
AAB41327
M33423
AAA40014
Q62120
NC_005100
NM_031514
NP_113702
AC_000069
AAHX01000018
AAHX01000019
AC109391
CH473953
EDM13086
EDM13087
AJ000557
CAA04188
U13396
AAA79911
Q62689
AMYH02019083
AAHY01142971
AAHY01142970
XM_006231195
AMYH02019081
AMYH02019082
XP_005251512
AAHY01142968
AAHY01142969
CAD13329
XM_005251455
AC_000041
AC_000141
NC_018920
ABBA01065417
ABBA01065418
XP_006231257
AABR06010486
AABR06010485
AABR06010487
NT_008413
NW_001839149
NW_924062
AC_000052
Q506Q0
Q52R86
Q8IXP2
NT_039687
NW_001030643
Q8CIN8
NW_001084774
NW_047565
O35804
24711711
409584
2288927
200572
BG066996
62947930
2570359
BG068848
595683
37590526
81866447
74728217
12643404
NW_000143
Q7TQD0
17384438
2499669
BG081632
2499668
62836431
BG080085
3236322
3068752
74725766
32451722
24981011
81894616
AI504024
74739295
AU023352
119579178
C81284
81886639
118430822
123187091
148709728
149062663
149062664

Swiss-Prot ID JAK2_HUMAN
JAK2_MOUSE
JAK2_RAT

Cell Localization Endomembrane system
Cytoplasm
Nucleus

Ensembl ID ENSG00000096968
ENSP00000371067.3
ENST00000381652.3
ENSMUSG00000024789
ENSMUSP00000025705.6
ENSMUST00000025705.6
ENSMUSP00000064394.3
ENSMUST00000065796.9
ENSMUSP00000158405.1
ENSMUST00000236990.1
ENSRNOG00000059968
ENSRNOP00000071877.1
ENSRNOT00000087011.1
ENSMUST00000025705
ENSMUST00000065796
ENST00000381652
ENSRNOP00000071877
ENSMUSP00000025705
ENSRNOT00000087011
ENSP00000371067
ENSRNOG00000015547
ENSMUSP00000064394
ENSRNOP00000021218
ENSRNOT00000021217

MGI ID MGI:96629
96629
2147795
2147569

RGD ID 2939

Unigene ID Rn.18909
Mm.275839
Hs.656213
Hs.591081
Mm.393199
Hs.434374

Homologene ID 21033

Shape Sickle-vertex

IPI ID IPI00207182
IPI00031016
IPI00122143
IPI00885005
IPI00476692

Homo sapiens Chromosome position 9p24

Ensembl Transcript ID ENST00000381652

ENSEMBL ENSG00000096968

FunctionalClass kinase
protein kinase
protein binding
protein-tyrosine kinase
nucleotide binding
SH2 domain binding
protein serine/threonine kinase
transferase
ATP binding
Janus kinase
receptor binding
growth hormone receptor binding

Mus musculus Chromosome position 19
19 24.0 cM

KEGG pathway Jak-STAT signaling pathway
Pancreatic cancer
Adipocytokine signaling pathway

Rattus norvegicus Chromosome position 1q51-q53

Ensembl Gene ID ENSG00000096968

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix
uterine; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: skeletal muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in tubules; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: follicle cells; Level: Weak; Expression type: Staining; Reliability: Supportive
uterine; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: seminal vesicle; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: lymphoid tissue; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: breast; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in granular layer; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: colon; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: duodenum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: epididymis; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: fallopian tube; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: gall bladder; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: heart muscle; Cell type: myocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: neuronal cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in glomeruli; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: bile duct cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: hepatocytes; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: macrophages; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: ovarian stroma cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: islets of Langerhans; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: parathyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: decidual cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: trophoblastic cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: prostate; Cell type: glandular cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: rectum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: salivary gland; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: small intestine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, lower; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: stomach, upper; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: thyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: germinal center cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: urinary bladder; Cell type: urothelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: vagina; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Negative; Expression type: Staining; Reliability: Supportive

LocatorString pmftq:achondroplasia