Protein DEFB4A

URN urn:agi-llid:1673
Total Entities 0
Connectivity 1330
Name DEFB4A
Description defensin beta 4A
Notes Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]
Class Transporter

Pathway Proteins Involved in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
IL17 Signaling in Psoriasis
Proteins Involved in Cystic Fibrosis
Proteins Involved in HIV Type 1 Infection
Diabetes Induced Periodontitis
Proteins Involved in Cholesteatoma
Proteins Involved in Otitis Media
Proteins Involved in Chronic Obstructive Pulmonary Disease
Elevated Receptors -> Expression Targets in Mouth
EGFR -> Expression Targets in Skin
IFNG/IFNR Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
EGFR-> Expression Targets in Lymphoid System and Blood
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
TNF -> STAT Expression Targets
TLR3 Expression Targets
TLR5 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
New Pathway (2)
Overview. Diseases of the skin (chapter 11)
1_Inflammation in keratinocytes in the pathology of acne
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
4_1_Polymorphisms associated with inflammatory bowel diseases
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins under Expressed in Pyelonephritis

MedScan ID 1673

LocusLink ID 1673

Alias defensin, beta 4A
DEFB4A
beta defensin 2
LOC115252
Skin-antimicrobial peptide I
beta-defensin 4A
beta-defensin II
defensin, beta II
hBD-2
DEFB2
SAP1
Skin-antimicrobial peptide 1
beta 2 defensin
defensin, beta 2
DEFB102
BD-2
DEFB4
DEFB-2
beta defensin-2
defensin, beta 4

GO ID 0031731
0042056
0007186
0061844
0019730
0060326
0006935
0050829
0050830
0042742
0006955
0031640
0050918
0005796
0005576
0005615
0045087

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Homo sapiens

OMIM ID 602215

Hugo ID 2767
HGNC:2767

Human chromosome position 8p23.1

Swiss-Prot Accession O15263
O15263.1

GenBank ID NC_000008
NM_004942
NP_004933
NW_018654717
NG_023301
AC130365
AC243982
AC270258
AF040153
AAC33549
AF071216
AAC69554
AJ000152
CAB65126
BC069285
AAH69285
BC093983
AAH93983
BC093985
AAH93985
BM855542
HY264007
Z71389
CAA95992
O15263
NC_018919
AMYH02017345
AMYH02017346
NW_001841719
ABBA01156881

Ensembl ID ENSG00000171711
ENSP00000303532.2
ENST00000302247.2
ENSP00000303532
ENST00000302247

Unigene ID Hs.105924

Shape Rhomb