Protein MAP2K6

URN urn:agi-llid:5608
Total Entities 0
Connectivity 937
Name MAP2K6
Description mitogen-activated protein kinase kinase 6
Notes This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Osteoarthritis
Skin Aging
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thrombopoietin Receptors Signaling in Platelet Maturation
Toll-like Receptors Act through MYD88-TIRAP Signaling
TLR4 Signaling in Leukocytes
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Scavenger Receptors in Platelet Activation
Bradykinin Effects in Inflammation
MC1R in anti-Inflammatory Signaling
Leukotriene Effect on Vascular Endothelial Cell Response
Leukotriene Effect on Airway Smooth Muscle Response
Basophil Activation
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
Neutrophil Recruitment and Priming
Neutrophil Degranulation via FPR1 Signaling
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Growth Factors
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
EDNRA/B -> Vascular Motility
ADRA1A -> IL6 Production
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
CHRM1 -> IL2 Production
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
IL1B Expression Targets -> Nociception
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Cardiomyocyte Dysfunction
Dendritic Cells Function in Atherosclerosis
Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
IL17 Signaling in Psoriasis
Dendritic Cells Function in Psoriasis
Podocyte Dysfunction in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
Osteoclast Activation in Multiple Myeloma
Antiphospholipid Antibodies and Endothelial Cell Interaction
IL33 Signaling Related Eosinophilia in Asthma
IgE Induces Airway Smooth Muscle Cell Proliferation
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoblast Function Decline in Gout
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
IL1B Induced Arthralgia
Dendritic Cell Dysfunction in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Skin Fibrosis
CCR5 Signaling in Macrophages
Apoptosis Block in Infected Cells
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Bone Loss in Osteoporosis
Hyperparathyroidism, Secondary Effect
Osteoclast Activation in Postmenopause
Glioma Invasion Signaling
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Microglia and Motor Neuron Interaction Dysregulation
Breast Cancer
Angiogenesis in Endometriosis
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Plasmin Role in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> AP-1 Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
CXCR4 -> ARRB1 Signaling
Sialophorin -> CTNNB/MYC/TP53 Signaling
CD72 -> NF-kB Expression Targets
CD8 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD86 -> NFATC Expression Targets
Complement Component GPCRs Signaling
Clozapine Induced Granulocytopenia
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
ADCYAP1 Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TGFB Signaling activation by Blocking of Tumor Suppressors
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF2/MEF/MYOD Expression Targets
Insulin -> MEF/MYOD Expression Targets
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> MEF/MYOD/MYOG Signaling
FibronectinR -> NF-kB Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
IL1R -> NF-kB Signaling
IL16-> ATF/CREB/CREBBP Expression Target
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
EDN1 Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
AngiopoietinR -> AP-1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TGFBR -> AP-1 Signaling
TGFBR -> CREB/ELK-SRF Signaling
TGFBR -> ATF/GADD/MAX/TP53 Signaling
TGFBR -> MEF/MYOD/MYOG Signaling
TNF-alpha/TNFRSF1A Signaling
TGF-beta Signaling
P38 MAPK/MAPK14 Signaling
VEGF Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
T-Cell Receptor -> ATF/CREB Signaling
TGFA -> TP53 Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> NF-kB Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF5/6 -> RB1/E2F Signaling
NGFR -> NF-kB Signaling
TNFR -> NF-kB Signaling
NGFR -> MEF Signaling
TNFRSF6 -> DDIT3 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR -> AP-1 Signaling
ER Stress (Unfolded Protein Response)
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
1_Inflammation in keratinocytes in the pathology of acne
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_Osteoclast-mediated bone resorption in postmenopausal women
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
4_2_Insulin resistance: inflammation-related insulin resistance
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Source curated

MedScan ID 5608

LocusLink ID 5608
26399
114495
19104
286883
568951

Alias MEK6
ERK kinase VI
Dual specificity mitogen-activated protein kinase kinase 6
MAPK/ERK kinase VI
Map2k6
SAPK kinase 3
MAPKK6
protein kinase, mitogen-activated, kinase VI
PRKMK6
MGC93287
OTTMUSP00000003317
Dual specificity mitogen-activated protein kinase kinase VI
RP23-162E10.1
MAP kinase kinase 6
MAPK kinase 6
OTTMUSP00000003318
MAPK kinase VI
MAP kinase kinase VI
MAPK/ERK kinase 6
protein kinase, mitogen activated, kinase 6
MKK6
ERK kinase 6
stress activated protein kinase kinase 3
SAPKK3
mitogen-activated protein kinase kinase VI
mitogen activated protein kinase kinase 6
protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
SAPKK-3
MAPKK 6
MEK 6
stress-activated protein kinase kinase 3
SKK3
mitogen-activated protein kinase kinase 6
protein kinase, mitogen-activated, kinase 6
PRKMK6s
MAPKK6s
SAPKK3s
kinase 6

EC Number 2.7.12.2
2.7.1.-

GO ID 0005524
0004708
0019901
0004674
0004713
0006975
0000165
0000187
0032147
0006915
0060048
0007050
0072709
0120163
0070423
0022602
0018108
0043065
0051770
0032308
0042493
0002931
0007165
0023014
0031098
0005737
0005856
0005829
0005654
0005634
0016301
0000166
0004672
0016740
0016310
0001934
0006468
0004702
0035897
0006355
0006351
0006950
0007346
0002755
0002756
0035666
0045087
0042692
0035872
0009405
0051149
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0016772
0005622
0035556
0008063
0034130
0008152
0005515

KEGG ID hsa:5608
mmu:26399
rno:114495

MedLine Reference 10848581
8621675
12213961
12556533
14744933
11593045
12477932
12829175
14709549
15492008
15722372
16755153
17007737
10097111
10349636
10922068
10949032
11042159
11076861
11217851
12151339
12466851
12482988
12824301
12893778
15644321
15767678
16141072
16141073
16199873
16387856
16498455
8861944
10497253
10570156
10961885
11062067
11279118
11460167
11727828
11836244
11971971
12054652
12509443
12589052
12761180
15375157
15516490
15550393
15677464
15778394
15790570
15866172
16313339
16342939
16344560
16728640
7750576
8622669
8626699
8663074
9218798
9373149
9430721
9768359
9841871
11282978
16305752
11104681
15489334
16960152
8125298
17214902
17588539

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 11
11 E1

OMIM ID 601254
OMIM:601254

Rat chromosome position 10q32.1

Hugo ID 6846
HGNC:6846

Human chromosome position 17q24.3

Swiss-Prot Accession A0A024R8K3
A8K3Y2
P52564
P52564.1
P70236
Q543Z5
P70236.1
Q925D6
Q60521
Q6MZH7
P70273
Q3UU57
Q8BP44
Q8C371
MP2K6_HUMAN
MP2K6_MOUSE
A8K3Y2_HUMAN
Q543Z5_MOUSE
Q925D6_RAT

PIR ID S71631
S71632

GenBank ID NC_000017
NM_002758
NP_002749
XM_005257516
XP_005257573
XM_011525027
XP_011523329
NM_001330450
NP_001317379
XM_011525026
XP_011523328
XM_006721975
XP_006722038
NG_029437
AC002546
AC015920
CH471099
EAW89084
EAW89085
EAW89086
EU332850
ABY87539
JX512448
AGC09595
KT585201
AA932919
AB451252
BAG70066
AB451376
BAG70190
AK056975
AK225719
AK290747
BAF83436
BC012009
AAH12009
BC037328
BX641121
CAE46056
D87905
BAA13496
DB111443
U39064
AAB03708
U39065
AAB03705
U39656
AAC50388
U39657
AAC50389
U49732
AAB05035
X96757
CAA65532
P52564
NC_000077
XM_011249034
XP_011247336
NM_011943
NP_036073
XM_011249035
XP_011247337
XM_006533378
XP_006533441
XM_006533377
XP_006533440
NM_001356345
NM_001356346
NM_001356347
NM_001356352
NM_001356353
AL691461
CH466558
EDL34384
EDL34385
EDL34386
EDL34387
AA389344
AI429449
AK043482
BAC31556
AK053547
AK077712
BAC36972
AK086722
BAC39729
AK138757
BAE23771
AK140289
AK141708
BAE24808
AK162671
BAE37014
BB202796
BE859531
BU695367
BY280286
BY284275
U39066
AAB03709
X97052
CAA65764
X98067
CAA66670
P70236
NC_005109
NM_053703
NP_446155
AC_000078
AABR07030670
AABR07030671
AABR07030672
AABR07030673
AAHX01066462
AAHX01066463
AAHX01066464
AAHX01066465
AAHX01066466
AAHX01066467
CH473948
EDM06489
EDM06490
EDM06491
AF369384
AAK53428
BC087004
AAH87004
XM_005257515
XP_005257572
XM_011525025
XP_011523327
NC_018928
AMYH02033884
AMYH02033885
DQ891488
ABM82414
DQ894673
ABM85599
XM_011249036
XP_011247338
XM_006533376
XP_006533439
AC_000033
AAHY01096284
AAHY01096285
AAHY01096286
AAHY01096287
AAHY01096288
AAHY01096289
BC075652
AAH75652
XM_005257517
XP_005257574
AC_000149
ABBA01028938
ABBA01028939
ABBA01028940
ABBA01028941
ABBA01028942
ABBA01028943
ABBA01028944
XM_006533375
XP_006533438
AABR06065948
AABR06065949
AABR06065950
AABR06065951
AABR06065952
AABR06065953
AABR06065954
AABR06065955
AL603826
CAM17458
CAM15928
CAM15929
NT_010783
NW_001838454
NW_926918
AC_000060
CR604345
CR616398
CR624804
CR625265
Q6MZH7
NT_165773
NW_001030434
P70273
Q3UU57
Q543Z5
Q60521
Q8BP44
Q8C371
NW_047343
NW_001084656
Q925D6
NT_010641
NM_031988
NT_096135
BG065128
NP_114365
NW_000040
BB261602
BG078419
34875497
NT_086886
NT_039521
56799416
16758520
14039929
14039930
56270320
56270321
51474120
14589899
14589900
14589901
14589902
51474508
15080539
15080540
1596164
1596165
1209670
1209671
1209672
1408567
1203815
1203816
1203817
1203818
1314476
1314477
1495484
1495485
1709088
51766637
33859653
33859654
26335710
26335711
26346646
26346647
49523345
49523346
1209674
1209675
1495701
1495702
1495709
1495710
3024165
81916439
123788527
26352185
74200485
74202136
74218281
81883904
81908495
81909188
81913452
81913971
119609491
123995995
1667613
59857961
75039372
75070059
AAB18824
AAX08815
BT020798
NC_007317
NM_001034045
NP_001029217
NW_001493708
P79118
Q5E9X2
U76873
144686011
ABP01909
EF489398
NC_007123
NW_001510704
XM_692311
XP_697403
119609490
119609492
123981170
34365448
123227427
148702437
148702438
148702439
148702440
149054672
149054673
149054674

Swiss-Prot ID MP2K6_HUMAN
MP2K6_MOUSE
A8K3Y2_HUMAN
Q543Z5_MOUSE
Q925D6_RAT

Cell Localization Nucleus
Cytoplasm
Cytoskeleton
Cytoplasm, cytoskeleton

Ensembl ID ENSG00000108984
ENSP00000467213.1
ENST00000589647.5
ENSP00000468348.1
ENST00000590474.7
ENSMUSG00000020623
ENSMUSP00000020949.5
ENSMUST00000020949.11
ENSRNOG00000004437
ENSRNOP00000006217.3
ENSRNOT00000006217.6
ENSP00000468348
ENST00000590474
ENSP00000467213
ENST00000589647
ENSMUSP00000020949
ENSMUST00000020949
ENSRNOP00000006217
ENSRNOT00000006217

MGI ID MGI:1346870
1346870
108032

RGD ID 620666

Unigene ID Hs.463978
Mm.14487
Rn.17256
Hs.256924
Bt.561
Dr.88531

Homologene ID 55686

Shape Sickle-vertex

IPI ID IPI00003814
IPI00219569
IPI00137439
IPI00205537
IPI00425919
IPI00796408
IPI00648735
IPI00781935

Microarray ID 849
OH7912
MB172
1387809_at
rc_ai176689_at
A_42_P748910
A_51_P256093
A_52_P299915
U39064
76095_at
205699_at
205698_s_at
1543_at
2014_s_at
U39657_at
A_23_P207445
A_14_P106514
A_14_P132828
A_14_P133360
A_24_P416489
A_14_P106339
A_14_P130621
M80
102828_at
102829_s_at

Homo sapiens Chromosome position 17q24.3

Ensembl Transcript ID ENST00000359094

FunctionalClass MAP kinase kinase
protein binding
ATP binding
kinase
nucleotide binding
protein kinase
protein serine/threonine kinase
protein-tyrosine kinase
transferase

Hugo Symbol MAP2K6

Bos taurus Chromosome position 19

Mus musculus Chromosome position 11 E1

KEGG pathway Toll-like receptor signaling pathway
MAPK signaling pathway
Fc epsilon RI signaling pathway
GnRH signaling pathway

Rattus norvegicus Chromosome position 10q32.1

Ensembl Gene ID ENSG00000108984

ProteinAtlas NormalTissue Tissue: cerebral cortex; Cell type: glial cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: lymph node; Cell type: non-germinal center cells; Level: Medium; Expression type: APE; Reliability: Medium
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Low; Expression type: APE; Reliability: Medium