Protein CEBPA

URN urn:agi-llid:1050
Total Entities 0
Connectivity 4535
Name CEBPA
Description CCAAT/enhancer binding protein (C/EBP), alpha
Notes This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway Androgen Deficiency in Male Obesity
Androgens in Adipocyte Activation
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Negative Acute Phase Proteins Synthesis
Adipokines Production by Adipocyte
Hematopoietic Cell Lineage: B-cell (mouse)
Androgens in Sebocyte Maturation
IL22 Induces Keratinocyte Proliferation in Psoriasis
Adiponectin Synthesis Declines in Insulin Resistance
Gluconeogenesis Impairment in non-Alcoholic Fatty Liver Disease
PNPLA3 in non-Alcoholic Fatty Liver Disease
Lipid Metabolism Impairement in non-Alcoholic Fatty Liver Disease
Graves Ophthalmopathy
Adipocyte Hypertrophy and Hyperplasia
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
Metastatic Colorectal Cancer
Proteins Involved in Acute Myeloid Leukemia
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
Chronic Myeloid Leukemia
Proteins Involved in Chronic Myeloid Leukemia
Eosinophil Activation and Degranulation in Asthma
Club-Cell Role in Asthma
Mast-Cell Activation in Asthma
Proteins Involved in Polycystic Ovary Syndrome
Li-Fraumeni Syndrome
Proteins Involved in Huntington Disease
Proteins Involved in Endometriosis
Fatty Acid Synthase (FASN) Signaling
Prostate Cancer
Proteins Involved in Prostate Cancer
Proteins Involved in Polycystic Kidney Disease
Elevated Receptors -> Expression Targets in Adipose Tissue
CCL3 Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> STAT Expression Targets
Elevated Receptors -> Expression Targets in Gallbladder
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
TERT Activation in Cancer
Cancer Cells Inhibit Adipocyte Differentiation
IGF1 -> CEBPA/FOXO1A Expression Targets
IGF2 -> CEBPA/FOXO1A Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IGF1R -> CEBPA/FOXO1A Signaling
IL6 Expression Targets
IL11 Expression Targets
Prostaglandin F Expression Targets
NOTCH -> Expression Targets in Thymus
OSM/OSMR Expression Targets
EDN1 Expression Targets
CSF1 -> STAT Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
IL1B Expression Targets
IL1A Expression Targets
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_The role of endothelial cells in pyelonephritis
2_Impaired steroidogenesis in PCOS
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
1_Triglyceride storage in NAFLD
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with Acute Myeloid Leukemia
Proteins Involved in Li-Fraumeni Syndrome

MedScan ID 1050

LocusLink ID 1050
12606
24252

Alias C/EBPa
CCAAT/enhancer binding protein alpha
LOC51011
CEBPA
CCAAT/enhancer-binding protein
DBPCEP
CCAAT/enhancer binding protein (C/EBP), alpha
OTTHUMP00000220269
CCAAT/enhancer binding protein
CAAT/enhancer binding protein alpha
C/EBP
transcription factor C EBP alpha
CEBP
CAAT/enhancer-binding protein, DNA-binding protein
CGI-105S
C/EBP-alpha
CCAAT/enhancer-binding protein alpha
CBF-A
C/ebpalpha
C/EBP alpha
CAAT/enhancer-binding protein DNA-binding protein
CCAAT/enhancer binding protein, alpha

GO ID 0003677
0001228
0003700
0000981
0000978
0019900
0042803
0003713
0008134
0044212
0007219
0050873
0048469
0071285
0071407
0071356
0008203
0019221
0001892
0045444
0006091
0042593
0030851
0048839
0070102
0055088
0001889
0030324
0030225
0007005
0030099
0008285
0045736
0000122
0045892
0045600
0050729
0043032
0045669
0032436
0045944
0045945
0006366
0006351
0000050
0016032
0050872
0090575
0043231
0005730
0005654
0005634
0005667
0071837
0001013
0042826
0019904
0046982
0044877
0043565
0007275
0045786
2000144
0045893
0042127
0006357
0006355
0006360
0036488
0035189
0016363
0032991
0006953
0031100
0030154
0035690
0007613
0002076
0071548
0007584
0080184
0033274
0003705
0001077
0032403
0043234
0051384
0019048
0010843
0003704
0044419
0010552
0016563
0016564

KEGG ID hsa:1050
mmu:12606
rno:24252

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 7 21.02 cM
7 12.0 cM

OMIM ID 116897
601626

Rat chromosome position 1q21
1q22

Hugo ID 1833
HGNC:1833

Human chromosome position 19q13.11
19q13.1

Swiss-Prot Accession P49715
P49715.3
P53566
P53566.2
P05554
P05554.3
A7LNP2
P78319
Q05CA4
Q91XB6
Q6P3S4
Q3U2H8
Q9QWK8

PIR ID JC4311
I49575
S06890

GenBank ID NC_000019
NM_004364
NP_004355
NM_001285829
NP_001272758
NM_001287435
NP_001274364
NM_001287424
NP_001274353
NG_012022
AC008738
EU048234
ABS82765
S75265
AAB33475
U34070
AAC50235
BC027902
AAH27902
BC063874
AAH63874
X87248
CAA60698
Y11525
CAA72289
P49715
NC_000073
NM_007678
NP_031704
NM_001287514
NP_001274443
NM_001287515
NP_001274444
NM_001287521
NP_001274450
NM_001287523
NP_001274452
AC150683
CH466618
EDL03027
M62362
AAA37374
AK155281
BAE33162
AK160443
AW045436
BC011118
AAH11118
BC028890
AAH28890
BC051102
AAH51102
BC058161
AAH58161
BC106174
P53566
NC_005100
NM_001287577
NP_001274506
NM_012524
NP_036656
NM_001287578
NP_001274507
NM_001287579
NP_001274508
AC_000069
AAHX01004671
AB020756
BAA36342
AC109741
CH473979
EDM07633
X12752
CAA31242
P05554
NC_018930
AMYH02035938
BC160133
AAI60133
AC_000029
AAHY01060488
AC_000151
ABBA01012597
ABBA01012598
AABR06004416
NT_011109
NW_927206
NW_001838492
AC_000062
Q6P3S4
NT_039413
NW_001030843
Q3U2H8
NW_001084763
NW_047557
Q9QWK8

Swiss-Prot ID CEBPA_HUMAN
CEBPA_MOUSE
CEBPA_RAT

Cell Localization Nucleus
Nucleolus
Nucleus, nucleolus

Ensembl ID ENSG00000245848
ENSP00000427514.1
ENST00000498907.3
ENSMUSG00000034957
ENSMUSP00000096129.4
ENSMUST00000042985.10
ENSRNOG00000010918
ENSRNOP00000063123.2
ENSRNOT00000014517.5
ENSP00000427514
ENST00000498907
ENSMUSP00000096129
ENSMUST00000042985
ENSRNOP00000063123
ENSRNOT00000014517

MGI ID MGI:99480
99480

RGD ID 2326

Unigene ID Hs.76171
Mm.349667
Hs.740432
Rn.204833

Homologene ID 3211

Shape O-vertex

IPI ID IPI00132435
IPI00200620
IPI00292025
IPI00383649