Protein IRAK4

URN urn:agi-llid:51135
Total Entities 0
Connectivity 2141
Name IRAK4
Description interleukin-1 receptor-associated kinase 4
Notes This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Osteoarthritis
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
Toll-like Receptors Act through MYD88-TIRAP Signaling
Antiviral Signaling through Pattern Recognition Receptors
Toll-like Receptors Act through MYD88 Signaling
TLR4 Signaling in Leukocytes
Th1-Cell Differentiation
Th17-Cell Differentiation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
IL1B Expression Targets -> Nociception
Proteins Involved in Atherosclerosis
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Myocardial Infarction
Proteins Involved in Myocardial Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Insulin Resistance in Myocytes Induced by Obesity
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
Celiac Disease
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Splenic Marginal Zone Lymphoma
Antiphospholipid Antibodies and Endothelial Cell Interaction
IL33 Signaling Related Eosinophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Th17-Cell Numbers Reduction in HIV
Toll-like Receptors (TLR) in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Microglia Activation in Alzheimer's Disease
HMGB1 and IL1B in Neuroinflammation
Microglia Activation in Parkinson's Disease
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
NFKB Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
NFKB Signaling Activation by Blocking of Tumor Suppressors
IDO1 in Cancer Immune Escape
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
NF-kB Canonical Signaling
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR4 -> IRF Signaling
TLR4/5/7/9 -> NF-kB Signaling
TLR1/2/6 -> NF-kB Signaling
TLR -> AP-1 Signaling
pathway 4
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
dsRNA induces innate immunity and INFs in alveolar cells
Innate immunity in Leukocytes
AGER feed forward loop in innate immunity
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
4_3_Insulin resistance: FFA-related insulin resistance
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell

MedScan ID 51135

LocusLink ID 51135
266632
300177
71485
77562
108842
239628

Alias RIKEN cDNA 9330209D03 gene
RIKEN cDNA 8430405M07 gene
OTTMUSP00000018066
LOC239628
interleukin-1 receptor associated kinase 4
IL-1 receptor associated kinase 4
9330209D03Rik
renal carcinoma antigen NY-REN-64
IRAK4
IL-1R associated kinase (IRAK) 4
NY REN 64 antigen
REN64
9330209D03
8430405M07
IPD1
IL-1R associated kinase 4
IL-1 receptor-associated kinase (IRAK) IV
8430405M07Rik
interleukin-1 receptor associated kinase (IRAK) 4
interleukin-1 receptor-associated kinase (IRAK) IV
LOC65651
IRAK-4 mutated form 1
IL-1 receptor associated kinase (IRAK) 4
OTTMUSP00000018065
IL-1 receptor-associated kinase IV
IL-1R-associated kinase IV
LOC95458
NY-REN-64
IL-1R-associated kinase (IRAK) IV
interleukin-1 receptor-associated kinase IV
LOC51135
IRAK-4
interleukin-1 receptor-associated kinase 4
IRAK

EC Number 2.7.11.1

GO ID 0005524
0005149
0000287
0004672
0004674
0007254
0002755
0001816
0019221
0045087
0070498
0035556
0002446
1990266
0043123
0051092
0048661
0034162
0002224
0005737
0005829
0010008
0005615
0005634
0005886
0016301
0000166
0016740
0002376
0016310
0006468
0007165
0005622
0034146
0034166
0038123
0045944
0016772
0038124
0034142
0034134
0008063
0034130
0004872
0007249
0005575
0005515
0003674
0004713

KEGG ID hsa:51135
mmu:266632
rno:300177

MedLine Reference 10508479
11923871
11960013
12297423
12477932
12496252
12637671
12721283
12860405
12925671
14702039
15084582
15292196
15489334
15825022
15905496
16286015
16286016
17046325
17141195
17161373
17217339
3772297
10349636
11042159
11076861
11217851
12466851
16141072
16141073
11544199
12538665
12682231
12819136
14634120
16040976
16177054
16179420
16574867
17178921
17337443
17360955
15890643

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 15
15 F1

OMIM ID 606883
610799
607676

Rat chromosome position 7q35

Hugo ID 17967
HGNC:17967

Human chromosome position 12q12

Swiss-Prot Accession B4E359
Q69FE3
Q9NWZ3
B2RAP9
Q9NWZ3.1
Q8R4K2
Q8R4K2.1
D4A7K4
Q69FE1
Q8TDF7
Q9Y589
Q80WW1
Q7Z6A7
Q7Z6A8
Q3USX5
Q9D250

GenBank ID NC_000012
XM_017019390
XP_016874879
NM_001351338
NP_001338267
NM_001351345
NP_001338274
NM_001351341
NP_001338270
NM_001351343
NP_001338272
NM_001351339
NP_001338268
NM_001114182
NP_001107654
NM_001145256
NP_001138728
NM_001351340
NP_001338269
NM_016123
NP_057207
NM_001145257
NP_001138729
NM_001351344
NP_001338273
NM_001351342
NP_001338271
NM_001145258
NP_001138730
XM_024449008
XP_024304776
XM_006719440
XP_006719503
XM_006719442
XP_006719505
XM_005268943
XP_005269000
XM_005268949
XP_005269006
XM_006719438
XP_006719501
XM_005268945
XP_005269002
XM_011538431
XP_011536733
XM_005268944
XP_005269001
XM_011538433
XP_011536735
NG_009892
AC093012
AX431306
CAD37279
AY186092
AAN75440
CH471111
EAW57867
AF155118
AAD42884
AF445802
AAM15772
AI126481
AK000528
BAA91232
AK027301
AK299944
BAG61774
AK304583
BAG65371
AK314288
BAG36946
AY283670
AAP57089
AY283671
AAP57090
AY340962
AAR02358
AY340963
AAR02359
AY340964
AAR02360
AY340965
AAR02361
AY340966
AAR02362
AY340967
AAR02363
AY730682
AAX22228
BC013316
AAH13316
DA290809
KU178631
ALQ34089
KU178632
ALQ34090
Q9NWZ3
NC_000081
XM_011245645
XP_011243947
NM_029926
NP_084202
AC147160
CH466550
EDL04264
EDL04265
AF445803
AAM15773
AK020397
BAB32090
AK028837
BAC26146
AK029028
AK078803
AK139992
BAE24205
BC051676
AAH51676
BE635313
Q8R4K2
NC_005106
NM_001106791
NP_001100261
XM_006242193
XP_006242255
AC_000075
AABR07058739
AABR07058740
AAHX01052385
CH474027
EDL76640
EDL76641
EDL76642
XM_011538432
XM_005268946
XM_005268947
XM_005268948
AAHY01124586
AAHY01124585
AAHY01124584
XP_006719506
XP_006719504
XP_006719502
ABM87133
AC_000037
AABR06052501
AABR06052500
DQ892885
XP_005269005
XP_005269004
XP_011536734
XP_005269003
AC_000144
NC_018923
LK938723
AMYH02026382
ABM83811
AABR06052502
XM_006719443
DQ896134
XM_006719439
ABBA01031423
XM_006719441
ABBA01031422
NT_029419
NW_925351
NW_001838057
AC_000055
Q69FE1
Q69FE3
Q7Z6A7
Q7Z6A8
NT_039621
NW_001030577
Q3USX5
Q9D250
NW_047783
NW_001084860
XM_001058330
XP_217026
XM_217026
XP_001058330
119578271
123987595
123999100
15426432
20219010
26000793
31871818
31871820
37727959
37727961
37727963
37727965
37727967
37727969
45220438
50401181
5360131
60502299
7020684
74708987
74713733
74738925
74758864
74759223
BAD12234
Q6ZWT8
15919912
123785112
148672317
148672318
20219012
26324784
30354528
50401077
74145960
81881248
BM220651
149017636
149017637
149017638

Swiss-Prot ID IRAK4_HUMAN
IRAK4_MOUSE
B2RAP9_HUMAN
Q69FE3_HUMAN
B4E359_HUMAN
D4A7K4_RAT
Q69FE1_HUMAN

Cell Localization Cytoplasm

Ensembl ID ENSG00000198001
ENSP00000446490.1
ENST00000551736.5
ENSP00000390327.1
ENST00000431837.5
ENSP00000408734.2
ENST00000440781.6
ENSP00000479889.2
ENST00000613694.4
ENSP00000390651.3
ENST00000448290.6
ENSMUSG00000059883
ENSMUSP00000074471.3
ENSMUST00000074936.9
ENSRNOG00000005965
ENSRNOP00000007932.4
ENSRNOT00000007932.5
ENST00000551736
ENSMUST00000074936
ENSMUSP00000074471
ENSP00000408734
ENSP00000390327
ENST00000431837
ENST00000613694
ENSRNOP00000007932
ENSRNOT00000007932
ENST00000440781
ENSP00000446490
ENSP00000479889

MGI ID MGI:2182474
2182474
1918735
1924812

RGD ID 1305303

Unigene ID Rn.61427
Hs.138499
Mm.422858

Homologene ID 41109

Shape Sickle-vertex

IPI ID IPI00153899
IPI00007641
IPI00798404
IPI00372984
IPI00385374
IPI00460849
IPI00755511
IPI00188049

Homo sapiens Chromosome position 12q12

FunctionalClass ATP binding
kinase
magnesium ion binding
nucleotide binding
protein binding
protein serine/threonine kinase
protein-tyrosine kinase
receptor
transferase
interleukin-1 receptor binding
protein kinase
molecular_function

Mus musculus Chromosome position 15 E3
15 F1

KEGG pathway Apoptosis
Toll-like receptor signaling pathway

Rattus norvegicus Chromosome position 7q35

Ensembl Gene ID LRG_75
ENSG00000198001