Pathway
|
Skin Aging
|
|
GCG and PPY Regulate Metabolism and Satiety
|
|
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
|
|
Taste Receptors Activation in Tongue
|
|
L-cell: GCG, PYY and 5-HT Release
|
|
P-cell Activation
|
|
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
|
|
D-cell: Somatostatin Release
|
|
A-cell (X-like): Ghrelin and Nesfatin-1 Synthesis
|
|
G-cell: Gastrin Secretion
|
|
ECL-cell: CHGA and Histamine Synthesis
|
|
Insulin Secretion
|
|
Dopamine Receptors Signaling
|
|
Serotonin Receptors Signaling
|
|
Catecholamines Secretion from Adrenal Gland
|
|
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
|
|
Norepinephrine Release Regulation
|
|
Dopamine Synthesis and Release
|
|
CRH Secretion Regulation
|
|
Prolactin Production
|
|
Oxytocin Action in Mammary Gland
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
Mineralcorticoids Secretion Regulation
|
|
Dectin-1 (CLEC7A) Signaling
|
|
Dectin-2 (CLEC6A)/Mincle (CLEC4E)/BDCA2 (CLEC4C) Signaling
|
|
T-Cell Dependent B-Cell Activation
|
|
T-Cell Independent B-Cell Activation
|
|
V(D)J Recombination Activation
|
|
Natural Killer Cell Activation through C-Type Lectin-like Receptors
|
|
Natural Killer Cell Activation through ITAM-Containing Receptors
|
|
Natural Killer Cell Activation through ITSM-Containing Receptors
|
|
T-Cell Maturation (Hypothesis)
|
|
Natural Killer Cell Activation
|
|
Peripheral T-Cell Tolerance
|
|
T-Cell Central Tolerance
|
|
CD8+ T-Cell Activation
|
|
Th1-Cell Differentiation
|
|
Treg-Cell Differentiation
|
|
Th2-Cell Differentiation
|
|
T-Cell Receptor Signaling
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Platelet Activation via Adhesion Molecules
|
|
Scavenger Receptors in Platelet Activation
|
|
Scavenger Receptors in Platelet Aggregation
|
|
Proplatelet Maturation
|
|
Bradykinin Effects in Inflammation
|
|
Platelet Activation via GPCR Signaling
|
|
Lipoxin A4/FPR2-Related Neutrophil Depression
|
|
Annexins in Inflammation Resolution
|
|
Eat me Signal: Apoptotic Cell Induces Phagocytosis
|
|
Leukotriene Effect on Vascular Endothelial Cell Response
|
|
Eicosanoids in Myeloid Cell Activation
|
|
Leukotriene Effect on Airway Smooth Muscle Response
|
|
Histamine Receptor H3 Signaling in Neurons
|
|
Prostaglandin E2 and Histamine in Gastric Acid Secretion
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Eosinophil Activation
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
Macrophage M2-Related Phagocytosis
|
|
anti-Inflammatory Function of Macrophage M2 Lineage
|
|
Neutrophil Recruitment and Priming
|
|
Neutrophil Activation via FCGR3B
|
|
Neutrophil Degranulation via FPR1 Signaling
|
|
CR3 Mediated Phagocytosis in Neutrophils and Macrophages
|
|
Neutrophil Chemotaxis
|
|
Neutrophil Activation via Adherence on Endothelial Cells
|
|
SNS Related Adrenal Cortex Response
|
|
Vascular Endothelial Cell Activation by NO
|
|
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
|
|
Vascular Endothelial Cell Activation by Cytokines
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Vascular Endothelial Cell Permeability Activation
|
|
Potassium Flux Regulation
|
|
GFs/TNF -> Ion Channels
|
|
Nociception Expression Targets Signaling
|
|
Vascular Motility
|
|
Ca2+ Flux Regulation
|
|
TAAR1 -> Neurotransmitter Uptake
|
|
NPY1R -> CRH/POMC Production
|
|
NTSR1 Expression Targets
|
|
CRH -> Synthesis of Corticosteroids
|
|
EDNRA/B -> Vascular Motility
|
|
CCKBR -> Neurotransmitter Uptake
|
|
ADORA3 -> Mast-Cell Degranulation
|
|
ADRA1 -> Vasoconstriction
|
|
ADRA1A -> IL6 Production
|
|
ADRA1 -> Ion Channels
|
|
ADRA2C/ADRB2 -> Vasoconstriction
|
|
ADRA2C/ADRB2 -> Synaptic Endocytosis
|
|
ADRA1 -> Prostaglandin Generation
|
|
BDKRB1/2 -> Ion Channels
|
|
BDKRB1/2 -> Prostaglandin Generation
|
|
CNR1/2 -> Membrane Transport
|
|
CNR1/2 -> Vascular Motility
|
|
CNR1/2 -> IL1B/2/4/6/10 Production
|
|
DRD2 Expression Targets
|
|
GALR1/2/3 -> POMC/NPY Production
|
|
GALR1/2/3 -> Neurotransmitter Metabolism
|
|
HRH1/2 -> Membrane Polarization
|
|
HRH1/3 -> Synaptic Transmission
|
|
HRH1/2 -> Vascular Motility
|
|
HRH2/4 -> IL6/10 Production
|
|
CHRM1 -> IL2 Production
|
|
CHRM1/2/3/5 -> Ion Channels
|
|
CHRM1/2/3 -> Vascular Motility
|
|
OPRK -> Pain Perception
|
|
PTGFR -> Vasoconstriction
|
|
PTGIR -> IL6 Production
|
|
PTGER1/4 -> Vascular Motility
|
|
PTGER2/3 -> Vascular Motility
|
|
PTGER2/3 -> Inflammation-Related Expression Targets
|
|
HTR1 -> IL6 Production
|
|
HTR5 -> TNF Production
|
|
HTR2 -> Membrane Transport
|
|
HTR1 -> Membrane Transport
|
|
HTR1 -> Vascular Motility
|
|
TACR1 -> Membrane Transport
|
|
TACR1 -> TNF/IL6/IL8 Production
|
|
GRM1/5 (Postsynaptic) -> Ion Channels
|
|
P2RY11/13/14 -> IL8/10 Production
|
|
P2RY1/2/4/6 -> Potassium Channels
|
|
NTRK1/2/3 -> Acetylcholine Production
|
|
EPHB -> NMDA Receptor Activation
|
|
Luteinizing Hormone in Oocyte Meiotic Resumption
|
|
Agomelatine Antidepressant Action
|
|
Histamine in Arousal Regulation
|
|
Circadian Clock in Sleep Regulation
|
|
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
|
|
Hypocretin (Orexin) in Arousal Regulation
|
|
Adenosine Role in Sleep Regulation
|
|
Retinal Ganglion and Suprachiasmatic Nucleus in Melatonin Synthesis Regulation
|
|
RHO Signaling (Light Signal Termination and Photoreceptor Recovery)
|
|
Vitamine D Deficite and Dentin Formation
|
|
G0/G1 Phase Transition
|
|
Gap Junction Assembly
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Endothelin Signaling in Arterial Hypertension
|
|
Arterial Hypertension
|
|
Aldosterone Synthesis Acute Regulation
|
|
Endothelial Cell Dysfunction in Arterial Hypertension
|
|
Aldosterone Synthesis Chronic Regulation
|
|
Smooth Muscle Cell Dysfunction in Arterial Hypertension
|
|
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
|
|
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
|
|
Myocardial Remodeling
|
|
Vascular Reactivity in Raynaud Disease
|
|
Cold Stress and Adrenoceptor alpha 2C Signaling in Raynaud Disease
|
|
NO Synthesis in Early Vasospasm
|
|
Neurons Necrosis Caused by Energy Deficiency
|
|
Contraction Due Vasospasm
|
|
Atopic Dermatitis Onset
|
|
Mast-Cells Activation in Atopic Dermatitis
|
|
Cell Cycle Dysregulation in Melanoma
|
|
WNT Signaling in Melanoma
|
|
Melanoma
|
|
Apoptosis Block in Melanoma Cell
|
|
MITF as a Regulator of Melanoma Cell Development
|
|
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
|
|
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Th2-Cell Function in Systemic Lupus Erythematosus
|
|
Oxidative Stress in Vitiligo
|
|
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Apoptosis of Melanocyte in Vitiligo
|
|
Humoral Immunity in Vitiligo
|
|
CD8+ T-Cell Response to Self-Determinants in Diabetes
|
|
Treg-Cell Function in Diabetes Mellitus Type 1
|
|
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
|
|
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
|
|
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
|
|
Natural Killer Cell in Diabetes Mellitus Type 1
|
|
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
|
|
Treg-Cell Activation in Diabetes Mellitus
|
|
Proliferative Diabetic Retinopathy
|
|
G-Proteins Signaling in Insulin Secretion in beta-Cell
|
|
Olanzapine Effect on Insulin Secretion in Diabetes Mellitus
|
|
Bone Remodeling in Hyperthyroidism
|
|
Cardiovascular Effects in Hyperthyroidism
|
|
Thyroid Dysfunction
|
|
Immune System Activation in Hyperthyroidism
|
|
GNRH Release Impairment in Hypogonadotrophic Hypogonadism
|
|
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
|
|
KISS1 Production Impairment in Hypogonadotropic hypogonadism
|
|
Hypothyroidism, Secondary (Central)
|
|
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
|
|
Overt Hypothyroidism, Primary
|
|
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
|
|
Central Hypothyroidism
|
|
Tertiary Hypothyroidism
|
|
Prolactinoma Overiew
|
|
CD4+T-Cell Response in Celiac Disease
|
|
CD8+ T-Cell Response in Celiac Disease
|
|
Metastatic Colorectal Cancer
|
|
B-Cell Activation in Crohn's Disease
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
CagA Phosphorylation Dependent Signaling
|
|
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
|
|
Th2-Cell Function in Ulcerative Colitis
|
|
T-Cell Cytotoxic Response in Ulcerative Colitis
|
|
Antiphospholipid Antibodies in Platelets and Coagulation Cascade
|
|
B-Cell Chronic Lymphocytic Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Diffuse Large-B-Cell Lymphoma ABC Subtype
|
|
Follicular Lymphoma
|
|
Hodgkin Lymphoma
|
|
Mantle Cell Lymphoma
|
|
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
|
|
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
|
|
Splenic Marginal Zone Lymphoma
|
|
Multiple Myeloma
|
|
Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
TRPM7/8 in Pancreatic Adenocarcinoma
|
|
Eosinophil Survival in Asthma
|
|
Eosinophil Activation and Degranulation in Asthma
|
|
Airway Smooth Muscle Cell High Rate Proliferation
|
|
IgE Induces Airway Smooth Muscle Cell Proliferation
|
|
Airway Smooth Muscle Cell Contraction
|
|
Goblet-Cell Exocytosis in Asthma
|
|
Neutrophil Degranulation via FPR1/IL8
|
|
Basophil Activation in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Mast-Cell Related Chemokines Signaling in Asthma
|
|
Antigen-Presenting Cell Role in Asthma
|
|
Th2-Cell Response in Asthma
|
|
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
|
|
Airway Epithelial Cell Dysfunction
|
|
CFTR Expression in Epithelial Cells (Class I Mutations)
|
|
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
|
|
Steroidogenesis Impairement in Polycystic Ovary Syndrome
|
|
Ovulation Block
|
|
Polycystic Ovary Syndrome
|
|
FSH Action in Polycystic Ovary Syndrome
|
|
PTPN22 Role in Rheumatoid Arthritis
|
|
B-Cells Function in Systemic Scleroderma
|
|
Th2-Cells Function in Systemic Scleroderma
|
|
WHIM Syndrome
|
|
Dentin Formation Disruption
|
|
CCR5 Signaling in Macrophages
|
|
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
|
|
CD4+ T-Cell Function Decline in HIV
|
|
Acinar Cells in the Saliva Formation
|
|
Epithelial Cell in the Saliva Formation
|
|
Glutamate Toxiicity Effects on Striatum Medium Spiny Neurons in Hantington's Disease
|
|
Ca2+ Overload in Muscular Dystrophies
|
|
Muscular Dystrophies
|
|
Ca2+ Toxicity in Neurons
|
|
BDNF Upregulation Triggered by Seizures
|
|
Blood-Brain Barrier Disruption in Epileptiform Disorders
|
|
mTOR Hyperactivation after Status Epilepticus
|
|
Glutamate, D-Serine, and ATP Release from Astrocytes
|
|
Glioblastoma, Primary
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
Vascular Endothelial Cell Vasodilation in Brain
|
|
CCL2 Role in CGRP Expression and Release
|
|
Dopamine Synthesis and Release in Migraine
|
|
Vascular Smooth Muscle Cell Vasodilation in Brain
|
|
Postsynaptic Neuron Activation
|
|
eNOS (NOS3) Activation via Prostaglandin E2 and Histamine
|
|
NO Effect on Vasodilation and Vasoconstriction
|
|
GABRB3 Mutation and Adenosine Deaminase Polymorphism
|
|
Hypocretin Elevation and Monoamine Oxidase Decrease/Inhibition
|
|
Brain Cell Necrosis in Vascular Dementia
|
|
Angiogenesis in Endometriosis
|
|
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
|
|
EGFR and PTAFR Signaling in Ovarian Cancer
|
|
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
|
|
Prostate Cancer
|
|
TRPM8 Effects in Prostate Cancer (Hypothesis)
|
|
Oxidative Stress, All-Trans-Retinal and Lipofuscin Toxicity in AMD
|
|
Ca2+ Toxicity in Lens Cells
|
|
VEGFA in Neovascular Glaucoma
|
|
Glutamate Mediated Excitotoxicity in Glaucoma
|
|
PGF2-alpha Effect on Treatment
|
|
Serotonin Signaling in the Ciliary Body
|
|
Cytokines Trigger Otitis Media
|
|
Alveolar Macrophages Dysfunction in COPD
|
|
Muscarinic Receptor-Mediated Airway Smooth Muscle Contraction
|
|
VEGFA Low Expression Level in Chronic Bronchitis
|
|
VEGFA High Expression Level in Pulmonary Emphysema
|
|
Alveolar Epithelial Cell Dysfunction in COPD
|
|
Penile Detumescense Augmentation Mechanisms
|
|
Endothelial Cell Dysfunction in Glomerulonephritis
|
|
Sertoli Cells Dysfunction Causes Male Infertility
|
|
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
|
|
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
|
|
CD38 -> cADPR/Calcium Signaling
|
|
CD157 -> cADPR/Calcium Signaling
|
|
ANGPT1 -> CREB/CREBBP Expression Targets
|
|
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
|
|
AREG -> NFATC Expression Target
|
|
AREG -> CREB/CREBBP Expression Targets
|
|
AREG -> NCOR2 Expression Targets
|
|
AREG -> SMAD1 Expression Target
|
|
AREG -> HIF1A Expression Targets
|
|
AREG -> AP-1 Expression Targets
|
|
Noradrenaline/Gs Expression Targets
|
|
Noreadrenaline/Gq Expression Targets
|
|
Epinephrine/Gs Expression Targets
|
|
Acetylcholine Expression Targets
|
|
Serotonin/Gq Expression Targets
|
|
Epinephrine/Gq Expression Targets
|
|
Dopamine/Gi Expression Targets
|
|
B-Cell Receptor -> NFATC Signaling
|
|
B-Cell Receptor -> AP-1 Signaling
|
|
B-Cell Receptor -> NF-kB Signaling
|
|
BTC -> NFATC Expression Targets
|
|
BTC -> AP-1/ATF/CREB Expression Targets
|
|
BTC -> EP300/ETS/ETV/SP1 Expression Targets
|
|
SELE -> ELK-SRF Signaling
|
|
CD2 Expression Targets
|
|
CD19 Expression Targets
|
|
CD81 -> AP-1 Expression Targets
|
|
CD247 Expression Targets
|
|
gamma Globulins Expression Targets
|
|
FCGR3A Expression Targets
|
|
CD19/CR2 Expression Targets
|
|
CD8 -> AP-1 Expression Targets
|
|
CD72 -> CREB/CREBBP Expression Targets
|
|
CD72 -> NF-kB Expression Targets
|
|
CD8 -> ATF/CREB/CREBBP Expression Targets
|
|
CD8 -> NF-kB Expression Targets
|
|
CD80 -> AP-1 Expression Targets
|
|
CD81 Expression Targets
|
|
CD80 -> NF-kB Expression Targets
|
|
CD80 -> NFATC Expression Targets
|
|
CD86 -> NFATC Expression Targets
|
|
CD86-> NFATC Expression Targets
|
|
CD86 -> NF-kB Expression Targets
|
|
CXCL6 Expression Targets
|
|
CXCL1 Expression Targets
|
|
CXCL2 Expression Targets
|
|
CXCL3 Expression Targets
|
|
CXCL5 Expression Targets
|
|
Inositol Phosphate Metabolism
|
|
Complement Component GPCRs Signaling
|
|
Doxorubicin Induced Cardiotoxicity
|
|
Clozapine Induced Granulocytopenia
|
|
Cyclosporine Induced Nephrotoxicity
|
|
EGF -> HIF1A Expression Targets
|
|
EGF -> AP-1/ATF Expression Targets
|
|
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
EGF -> MEF/MYOD/NFATC Expression Targets
|
|
EGF -> TP53 Expression Targets
|
|
EGF -> NCOR2 Expression Target
|
|
EGFR -> NCOR2 Signaling
|
|
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
|
|
EGFR/ERBB2 -> TP53 Signaling
|
|
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
|
|
EGFR -> SMAD1 Signaling
|
|
EGFR/ERBB2 -> HIF1A Signaling
|
|
EGFR -> AP-1/ATF2 Signaling
|
|
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
|
|
EREG -> CREB Expression Target
|
|
EREG -> EP300/SP1 Expression Targets
|
|
EREG -> HIF1A Expression Target
|
|
EREG -> AP-1/ATF Expression Targets
|
|
Erythropoietin -> AP-1/MYC/CREB Expression Targets
|
|
Erythropoietin -> ELK/SRF Expression Targets
|
|
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
|
|
FGF9 -> AP-1/CREB/MYC Expression Targets
|
|
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
FGF1 -> NCOR2 Expression Target
|
|
FGF7 -> RUNX Expression Targets
|
|
FGF8 -> AP-1/CREB/MYC Expression Targets
|
|
FGF1 -> RUNX Expression Targets
|
|
FGF18 -> AP-1/CREB Expression Targets
|
|
FGF23 -> NCOR2 Expression Targets
|
|
FGF8 -> RUNX Expression Targets
|
|
FGF9 -> RUNX Expression Targets
|
|
FGF2 -> NCOR2 Expression Targets
|
|
FGF4 -> AP-1/MYC Expression Targets
|
|
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
FGF2 -> RUNX Expression Targets
|
|
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
FGFR -> RUNX2 Signaling
|
|
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
|
|
FPR1 -> Cytoskeleton Signaling
|
|
ADCYAP1 Expression Targets
|
|
FSHR Expression Targets
|
|
Glutamate/Gq Expression Targets
|
|
VIP Expression Targets
|
|
HBEGF -> AP-1/ATF Expression Targets
|
|
HBEGF -> TP53 Expression Targets
|
|
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
|
|
HBEGF -> HIF1A Expression Targets
|
|
HBEGF -> MEF/MYOD Expression Target
|
|
HBEGF -> CREB/MYC Expression Targets
|
|
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
|
|
HGFR -> AP-1/CREB/MYC Signaling
|
|
EGFR Transactivation in Cancer and Non-Cancer Cells
|
|
TAM Receptor Signaling Activation in Cancer
|
|
G0/G1 Cell Cycle Phase Transition Activation in Cancer
|
|
NFKB Canonical Signaling Activation in Cancer
|
|
VEGF Independent Angiogenesis in Cancer
|
|
CDH2 Activation Promotes Cancer Cell Migration and Survival
|
|
Treg Cells Promote Immunosuppression in Cancer Immune Escape
|
|
Effector T-cell Inactivation in Cancer Immune Escape
|
|
CD2 -> NFATC1 Signaling
|
|
CD19 -> JUN/ELK Signaling
|
|
FcIgER -> NFATC1 Signaling
|
|
FcIgER -> ELK-SRF Signaling
|
|
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
|
|
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
|
|
CTGF -> AP-1/CREB/MYC Expression Targets
|
|
CTGF -> NCOR2 Expression Target
|
|
ICAM1 Expression Targets
|
|
IL16 -> AP-1 Expression Targets
|
|
IL16-> ATF/CREB/CREBBP Expression Target
|
|
UrokinaseR -> ELK/SRF Signaling
|
|
PTPRC -> BCL6 Expression Targets
|
|
Prostaglandin F Expression Targets
|
|
Thromboxane A2 Expression Targets
|
|
LPA Expression Targets
|
|
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
|
|
Dronabinol/Anandamide Expression Targets
|
|
Morphine Expression Targets
|
|
PAF/Gq -> NF-kB Expression Targets
|
|
S1P Expression Targets
|
|
PGE1 Expression Targets
|
|
NRG1 -> MEF/MYOD Expression Targets
|
|
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
|
|
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
|
|
NRG1 -> TP53 Expression Target
|
|
NRG1 -> AP-1/ATF Expression Targets
|
|
NRG1 -> HIF1A Expression Target
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NGF -> SMAD3/NF-kB Expression Targets
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NGF -> AP-1/TP53/MYC Expression Targets
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NGF -> FOXO/MYCN/ELK-SRF Expression Targets
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BDNF Expression Targets
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NTF3 Expression Targets
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NTF4 Expression Targets
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NGF -> CREB/CEBPB/MEF2A Expression Targets
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Adenosine Expression Targets
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PDGFB -> AP-1/CREB/MYC Expression Target
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PDGFC -> CREB Expression Target
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PDGFD -> AP-1 Expression Targets
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PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
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KIT -> MITF Signaling
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PDGFR -> AP-1/MYC Signaling
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AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
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GNRH1 Expression Targets
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NTS Expression Targets
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GAST Expression Targets in GAST Expression Targets
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AGT -> TP53 Expression Targets
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GNRH2 Expression Targets
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OXT Expression Targets
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POMC Expression Targets
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CCL11 Expression Targets
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EDN1 Expression Targets
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AGT -> CREB Expression Targets
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AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
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NPY Expression Targets
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AVP/Gq -> STAT Expression Targets
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IFNA1/Gq Expression Targets
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AGT -> ELK/SRF Expression Targets
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TAC1 Expression Targets
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AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
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EDN3 Expression Targets
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AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
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PDCD1 -> ATF/CREB/CREBBP Expression Targets
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PDCD1 -> NFATC Expression Targets
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PDCD1 -> AP-1 Expression Targets
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PTPRC -> BCL6 Signaling
|
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AngiopoietinR -> AP-1 Signaling
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GDNF -> HSF1 Signaling
|
|
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
|
|
GAS6 -> AP-1/CREB Expression Targets
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|
FIGF -> AP-1 Expression Target
|
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FIGF -> NCOR2 Expression Target
|
|
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
GDNF -> HSF1 Expression Targets
|
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CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
|
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FLT3LG -> AP-1/CREB/CREBBP Expression Targets
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|
WNT/Calcium non-Canonical Signaling
|
|
Lysophosphatidic Acid/LPARs Signaling
|
|
Ras-GRF Regulation Signaling
|
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MERTK Signaling
|
|
Ras Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
VEGF Signaling
|
|
Estrogens/ESR1 non-Genomic Signaling
|
|
EGFR Signaling
|
|
NF-kB Canonical Signaling
|
|
ERK/MAPK Canonical Signaling
|
|
TCR -> CREB/CREBBP/ATF Expression Targets
|
|
TCR -> NF-kB Expression Targets
|
|
TCR -> NFAT Expression Targets
|
|
TCR -> AP-1 Expression Targets
|
|
T-Cell Receptor -> AP-1 Signaling
|
|
T-Cell Receptor -> NF-kB Signaling
|
|
T-Cell Receptor -> NFATC Signaling
|
|
T-Cell Receptor -> CREBBP Signaling
|
|
TGFA -> TP53 Expression Targets
|
|
TGFA -> HIF1A Expression Targets
|
|
TGFA -> MEF/MYOD/NFATC Expression Targets
|
|
TGFA/AP-1/ATF Expression Targets
|
|
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
|
|
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
|
|
IL1B -> PGE2 Expression Targets
|
|
ROS in Neutrophil Mediated Cell Damage
|
|
ROS in Triggering Vascular Inflammation
|
|
ROS and RNS in Vasoconstriction and Vasodilation Regulation
|
|
Ca2+ Cytosolic Overload
|
|
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
|
|
PLAU -> ELK-SRF/AP-1 Expression Targets
|
|
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
|
|
VEGFA -> NFATC Expression Targets
|
|
VEGFC -> ATF Expression Target
|
|
VEGFA -> AP-1/CREBBP/MYC Expression Targets
|
|
VEGFA -> NCOR2 Expression Target
|
|
VEGFR -> NFATC Signaling
|
|
VEGFR -> AP-1/CREB/MYC Signaling
|
|
VEGFR -> ATF/CREB/ELK-SRF Signaling
|
|
ace2
|
|
cypa
|
|
Model of PPARG signaling in psoriasis
|
|
New Pathway
|
|
2_Acute phase initiation in atopic dermatitis
|
|
1_The onset of atopic dermatitis
|
|
2_Podocyte dysfunction in glomerulonephritis
|
|
3_Enhanced angiogenesis in endometriosis
|
|
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
|
|
2_Oxidative stress, all-trans-retinal, and lipofuscin toxicity in agerelated macular degeneration
|
|
2_Pathogens stimulate mucins expression in the middle ear
|
|
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
|
|
2_Cardiomyocyte hypertrophy
|
|
3_Dysfunction of smooth muscle cells in hypertension
|
|
4_Endothelial cells repress vasoconstriction in hypertension
|
|
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
|
|
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
|
|
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
|
|
3_1_Mucus accumulation in asthma
|
|
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_1_Airway smooth muscle cells contraction
|
|
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
|
|
4_Mucin hyperproduction in goblet and mucous cells in COPD
|
|
1_CD4+ T cell and epithelial cell response in celiac disease
|
|
2_CD8+ T-cell response and mucosal damage in celiac disease
|
|
1_2_Insulin synthesis and secretion: insulin secretion
|
|
1_1_Insulin synthesis and secretion: insulin processing and storage
|
|
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
|
|
3_Islet beta-cell destruction in T1D
|
|
3_Pain perception in diabetic neuropathy
|
|
2_Neuron and Schwann cell death
|
|
1_1_Glutamate overload enforced prostaglandins and NO synthesis in neurons
|
|
1_2_Glutamate overload and NO-mediated vasodilation
|
|
1_Decreased secretion of thyroid hormones
|
|
2_1_General pathways of thyroid hormone signaling
|