Protein STAT3

URN urn:agi-llid:6774
Total Entities 0
Connectivity 11402
Name STAT3
Description signal transducer and activator of transcription 3 (acute-phase response factor)
Notes The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Primary Cell Localization Nucleus
Class Transcription factor
ObjectType Protein

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
Apoptosis of Cochlear Hair Cells (Noise-Induced, Mouse Model)
mTOR Signaling
Telomer Attrition Triggers Genomic Instability
Leptin and CCK8 Activate Nodose Ganglia Neuron
P-cell Activation
I-cell: CCK-8 Secretion and Regulation of Eating Behavior
N-cell: Neurotensin Production
Serotonin Receptors Signaling
PRL and CSH Action in Mammary Gland
Thrombopoietin Receptors Signaling in Platelet Maturation
T-Cell Maturation (Hypothesis)
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Proplatelet Maturation
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CXCR4 Signaling
Mast-Cell Activation without Degranulation
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
CCR1 Expression Targets
ADRA1A -> IL6 Production
PTGER2/3 -> Inflammation-Related Expression Targets
IL6 Expression Targets -> Nociception
Leptin -> CD25/IL6/IL10 Production
CHRNA7 -> IL8 Production
Proteins Involved in Atherosclerosis
Proteins Involved in Dilated Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Proteins Involved in Pulmonary Hypertension
Endothelial Cell Dysfunction in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Preconditioning Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Hair Follicle Keratinocyte Apoptosis
Proteins Involved in Atopic Dermatitis
Melanoma
Apoptosis Block in Melanoma Cell
Proteins Involved in Melanoma
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
Donohue Syndrome Progression (Hypothesis)
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Proliferative Diabetic Retinopathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Insulin Resistance in Myocytes Induced by Obesity
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
Leptin in Insulin Synthesis and Secretion
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hashimoto's Thyroiditis
RET1 Mutation in Hyperparathyroidism
Thyroid Hormones in Adipose Tissue Metabolism
Thyroid Dysfunction
Graves Ophthalmopathy
KISS1 Production Impairment in Hypogonadotropic hypogonadism
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyrotropin Releasing Hormone (TRH) Hypothalamic Release in non-Autoimmune Hypothyroidism
Central Hypothyroidism
Tertiary Hypothyroidism
SOCS3 and PTPN1 in Hypothalamic Neuron Insensitivity to Insulin and Leptin
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
CD4+T-Cell Response in Celiac Disease
Proteins Involved in Colorectal Neoplasms
Cetuximab Resistance in Colorectal Cancer
Metastatic Colorectal Cancer
EGFR Nuclear Signaling in Colorectal Cancer
Crohn's Disease
Paneth-Cell Function in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Peutz-Jeghers Syndrome
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
B-Cell Acute Lymphoblastic Leukemia
Chronic Myeloid Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Proteins Involved in Diffuse Large-B-Cell Lymphoma
Follicular Lymphoma
Proteins Involved in Hodgkin Lymphoma
Proteins Involved in Mantle Cell Lymphoma
Mantle Cell Lymphoma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
Proteins Involved in Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Hepatocellular Carcinoma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
TRPM7/8 in Pancreatic Adenocarcinoma
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Th17-Cell Differentiation in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
Skin Fibrosis
Th17-Cell Numbers Reduction in HIV
Diabetes Induced Periodontitis
Cowden Syndrome
Gluten Impact on Neuronal System (Hypothesis)
beta-Casomorphins/Opioid Receptors Affect Brain Function (Hypothesis)
IL6 and Insulin Resistance in Muscular Dystrophies
IL6 Promotes Inflammation in Muscular Dystrophies
Bone Loss in Osteoporosis
Proteins with Altered Expression in Rheumatoid Arthritis
Proteins Involved in Epilepsy
BDNF Upregulation Triggered by Seizures
Glioblastoma, Primary
Proteins Involved in Glioblastoma
Glioblastoma, Secondary
Astrocytoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Glioma Stem Cell Program Activation
Neuroblastoma
ALK Associated Neuroblastoma
Proteins Involved in Parkinson's Disease
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Proteins Involved in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in High-Grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Proteins Involved in Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
Proteins Involved in Mucinous Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Proteins Involved in Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Proteins Involved in Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
MIF Role in Cholesteatoma
IL6/JAK/STAT3 Signaling in Cholesteatoma
Cholesteatoma
Prostate Cancer
Proteins Involved in Prostate Cancer
TLR3 Role in Retinal Pigment Epithelial Cell
IL10/STAT3 Signaling in M2 Macrophage and Retinal Angiogenesis
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Proteins Involved in Noise-Induced Hearing Loss
Cochlear Inflammation (Noise-Induced)
Alveolar Macrophage Negative Regulation Declined in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Polycystins Mutation Effects in Cystic Kidney Disease
Proteins Involved in Polycystic Kidney Disease
Proteins Involved in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
ANGPT2 -> STAT Expression Targets
ANGPT1 -> STAT Expression Targets
AREG -> STAT Expression Targets
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
BTC -> STAT Expression Targets
IFNG -> ARRB1/STAT1 Signaling
CD2 Expression Targets
CD22 -> STAT Expression Targets
CD8 -> NFATC Expression Targets
CD80 -> ATF/CREB/CREBBP Expression Targets
CD86 -> ATF/CREB/CREBBP Expression Targets
CLCF1 Expression Targets
CXCL12 Expression Targets
CCL3 Expression Targets
CCL3L1 Expression Target
CCL16 Expression Targets
CCL5 Expression Targets
CCL7 Expression Target
CCL7 Expression Targets
CCL8 Expression Targets
CCL15 Expression Targets
CCL2 Expression Targets
IL8 Expression Targets
CSF3 Expression Targets
CSF2 -> STAT Expression Targets
CNTF Expression Targets
Clozapine Induced Granulocytopenia
EGF -> STAT Expression Targets
EGFR/ERBB -> STAT Signaling
EREG -> STAT Expression Targets
Erythropoietin -> STAT Expression Targets
PECAM1 Expression Targets
FGF2 -> STAT Expression Targets
FGF10 -> STAT Expression Targets
FGF18 -> STAT Expression Targets
FGF1 -> STAT Expression Targets
FGF9 -> STAT Expression Targets
FGF8 -> STAT Expression Targets
FGFR1 -> STAT Signaling
FGFR3 -> STAT Signaling
GH2/GHR Expression Target
GH1/GHR -> STAT Expression Targets
CSH1/GHR Expression Targets
CSH1/PRLR Expression Targets
GH1/PRLR Expression Targets
HBEGF -> STAT Expression Targets
HGF -> STAT Expression Targets
HGFR -> STAT Signaling
TAM Receptor Signaling Activation in Cancer
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
Proteins with Altered Expression in Tumor-Promoting Inflammation
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
Apoptosis Block by Inhibitor of Apoptosis Proteins (IAPs) in Cancer
Proteins with Altered Expression in Cancer-Associated Resisting to Cell Death
Suppression of Caspase Activity in Cancer
Apoptosis Evasion in Cancer: Overview
TERT Activation in Cancer
Proteins with Altered Expression in Cancer-Associated Enabling of Replicative Immortality
VEGFA Dependent Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival
Skeletal Muscle Wasting in Cancer Cachexia
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
CD46/CD55/CD59 Inhibit Complement Mediated Lysis of Cancer Cells
EZH2 Methyltransferase Role in Cancer
IGF2 -> STAT Expression Targets
IGF1 -> STAT Expression Targets
Insulin -> STAT Expression Targets
CD2 -> STAT Signaling
ICAM2 -> CTNNB/FOXO/STAT3 Signaling
PECAM -> STAT Signaling
InsulinR -> STAT Signaling
IGF1R -> STAT Signaling
Elevated Receptors -> Expression Targets in Skin
IFNLR1-> STAT/NFKB Signaling
IFNW1/IFNR Expression Target
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL22R -> STAT3 Signaling
IL31R -> STAT Signaling
IL15R -> STAT Signaling
IL1R -> STAT3 Signaling
IL10R -> STAT Signaling
IL13R -> STAT Signaling
IL3R -> STAT Signaling
IL27R -> STAT Signaling
IL7R -> STAT Signaling
IL9R -> STAT Signaling
IL5R -> STAT Signaling
IL11R -> STAT3 Signaling
IL6R -> STAT Signaling
IL2R -> STAT Signaling
IL12R -> STAT Signaling
IL23R -> STAT3/NF-kB Signaling
IL21R -> STAT Signaling
IL7 Expression Targets
IL13 Expression Targets
IL21 Expression Targets
IL15 Expression Targets
IL12B Expression Targets
IL3 Expression Targets
IL16 -> STAT Expression Targets
IL6 Expression Targets
IL10 Expression Targets
IL5 Expression Targets
IL22 Expression Targets
IL11 Expression Targets
IL9 Expression Targets
IL31 Expression Targets
IL2 Expression Targets
Leptin -> STAT Expression Targets
Morphine Expression Targets
NRG1 -> STAT Expression Targets
OSM/OSMR Expression Targets
PDGFC -> STAT Expression Target
PDGFD -> STAT Expression Targets
PDGF -> STAT Expression Targets
PDGFB -> STAT Expression Target
PDGFR -> STAT Signaling
CSF2 -> STAT Signaling
KIT -> STAT Signaling
GAST Expression Targets in GAST Expression Targets
POMC Expression Targets
CCL11 Expression Targets
AVP/Gq -> STAT Expression Targets
IFNA1/Gq Expression Targets
AVP/Gs -> STAT Expression Targets
AGT -> STAT Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
ProlactinR -> STAT Signaling
PDCD1 -> STAT Expression Targets
ALK -> STAT Signaling
AngiopoietinR -> STAT Signaling
EphrinR -> STAT Signaling
CSF1 -> STAT Expression Targets
MDK/PTN Expression Targets
KITLG -> STAT Expression Targets
EphrinR Expression Targets
EFNA1 -> STAT Expression Target
PAF Expression Targets
FOXO1 Signaling
BMPR2 Signaling
Ras-GAP Regulation Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
TCR -> STAT Expression Targets
T-Cell Receptor -> STAT Signaling
TGFA -> STAT Expression Targets
LTA Expression Targets
CD40LG -> STAT Expression Targets
TNF -> STAT Expression Targets
TNFRSF5 -> STAT Signaling
TNFRSF1A -> STAT Signaling
Thrombopoietin -> STAT Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
VEGFA -> STAT Expression Targets
VEGFR -> STAT Signaling
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of tumor grade
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of infarct area
Neighbors of fertility
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of bone volume
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of lesion area
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of viral load
Neighbors of blood pressure
Neighbors of tumor grade
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of tumor aggressiveness
Neighbors of systolic blood pressure
Neighbors of tumor resistance
Neighbors of blood glucose
Neighbors of ejection fraction
Neighbors of median survival
Neighbors of fasting plasma glucose
Neighbors of T-cell count
Neighbors of antimetastatic activity
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of infarct area
Neighbors of fertility
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of bone volume
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of monocyte
Neighbors of macrophage
Neighbors of intestine epithelium cell
Neighbors of hepatocyte
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of inflammatory cell
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of cardiac myocyte
Neighbors of myeloid cell
Neighbors of stem cell
Neighbors of leukocyte
Neighbors of insulin-secreting cell
Neighbors of T-cell
Neighbors of hematopoietic cell
Neighbors of podocyte
Neighbors of antigen-presenting cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of blood vessel
Neighbors of heart
Neighbors of microvessel
Neighbors of uterus
Neighbors of esophagus
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of artery
Neighbors of pancreas
Neighbors of prostate
Neighbors of decidua
Neighbors of immune system
Neighbors of vein
Neighbors of ankle joint
Neighbors of thymus gland
Neighbors of brain blood vessel
Neighbors of myelin sheath
Neighbors of blastocyst
Neighbors of nerve
Neighbors of NF-kB family
Neighbors of PPAR
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of cytokine
Neighbors of JAK
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of ovalbumin
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of estrogen receptor
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of proteasome endopeptidase complex
Neighbors of non-coding RNA
Neighbors of STAT5
Neighbors of retinoid-X receptor subfamily
Neighbors of WNT
Neighbors of PP2B
Neighbors of TORC1
Neighbors of Rho kinase
Neighbors of PDGF receptor
Neighbors of caspase
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
New Pathway (5)
New Pathway (3)
sars-cov no binding
H2A-K119 and H3-K27
New Pathway
IFN signaling in alveolar cells
Possible Interplay between SOX11, CCND1 and EZH2 in Mantle Cell Lymphoma
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
1_Differentiation of psoriatic T cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_Formation of cysts in polycystic kidney disease
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
3_Increased proliferation of pulmonary artery smooth muscle cells (PASMCs) in familial forms of pulmonary hypertension
2_Cardiomyocyte hypertrophy
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Inflammatory mediators increase the production of hepcidin (HAMP)
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Defective tolerance of autoreactive T-cell in T1D
1_Decreased secretion of thyroid hormones
Model of PPARG signaling in psoriais (tested)
before laser treatment
New Pathway
Differentiation of psoriatic T cells
Interleukin-17 and interleukin-22 signaling in psoriasis
Anti-psoriatic drugs influence PPARG signaling
PPARG signaling after laser treatment

Group Genes with Mutations Associated with Inflammatory Bowel Diseases
Proteins Involved in Cowden Syndrome
other partners for SARS

Source curated
ResNet
GO component

MedScan ID 6774

LocusLink ID 6774
20848
25125
68733
104593
114129
508541
282085
30767
323957
334563
793847
50949

Alias 1110034C02
Signal transducer and activator of transcription III
STAT3 transcription factor
Signal transducer and activator of transcription 3
signal transducer and activator of transcription 3 isoform 2
signal transducer and activator of transcription 3 (acute-phase response fa
FLJ20882
MGC16063
OTTMUSP00000002053
DNA-binding protein APRF
1110034C02Rik
Hyper-IgE syndrome gene
signal transducer and activator of transcription 3 isoform II
signal transducer and activator of transcription 3 isoform 1
RP23-279L23.5
HIES gene
MGC93551
APRF
Hyper-IgE syndrome protein
transcription factor STAT3
RIKEN cDNA 1110034C02 gene
HIES protein
OTTMUSP00000045316
OTTMUSP00000002052
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
OTTMUSP00000045315
signal transducer and activator of transcription 3 isoform I
acute phase response factor
AW109958
ADMIO1 gene
HIES
ADMIO
ADMIO1
acute-phase response factor
Acute-phase response factor
hypothetical protein MGC16063

GO ID 0031730
0003677
0001228
0003700
0000981
0000978
0001103
0031490
0035259
0004879
0042803
0019901
0019903
0008134
0044212
0007259
0060397
0072540
0006953
0007568
0048708
0008283
0071345
0032870
0044320
0071407
0019221
0006952
0042755
0097009
0001754
0042593
0060396
0006954
0035723
0038114
0038155
0070106
0070757
0070102
0038111
0038113
0030522
0033210
0042789
0035278
0050804
0043066
0010507
0008285
0045820
0010730
1901215
2001223
2000737
0000122
0007399
0016310
2001171
0051092
0045747
0045766
0030335
0045648
0010628
2000637
1902728
0045410
1904685
1902895
0045944
0045893
0042531
1905564
0099527
0006606
0060019
0051726
0042127
0060259
0046902
0040014
0006357
0006355
0032355
0045471
0044321
0043434
0019953
0007165
0035019
0001659
0016032
0090575
0098685
0005737
0005829
0098978
0005743
0000790
0005654
0005634
0005886
0014069
0005667
0043565
0060548
0008284
0034097
0019827
0006366
0005739
0042493
0014070
0010033
0006351
0001077
0005622
0005509
0005515
0046983
0048011
0004871
0019048
0005730
0006928
0042517
0016563
0044419
0055091
0005062
0045449
0006350
0007242

KEGG ID hsa:6774
mmu:20848
rno:25125

MedLine Reference 10323205
11710966
11799081
11867182
11872739
12080006
12087100
12130569
12153141
12191995
12242030
12392283
12477932
12487370
12494267
12498781
12528179
12531244
12584205
12595539
12695539
12847226
14678947
14725620
14767990
15007380
15060019
15187153
15256805
15292470
15322111
15469886
15476586
15548519
15590660
15591053
15716400
15860735
15893771
15948155
15948243
15998644
16025117
16127698
16225866
16300827
16306356
16413512
16514419
16551428
16565302
16616937
16764840
16809483
16931573
16934228
16971535
8530402
9716657
10023769
10077599
10080923
10200816
10205054
10349636
10428964
10458605
10469645
10521404
10526573
10675904
10725249
10781587
10781830
10851050
10851059
10851062
10867663
10922068
10978511
11013085
11042159
11076861
11087819
11089524
11161808
11180952
11217851
11238899
11239451
11275690
11437454
11520461
11579100
11591128
11726030
11735219
11739197
11764284
11807093
11812786
11853668
11861304
11881154
11889125
11964286
12032149
12049654
12057007
12061821
12084939
12090754
12093727
12111703
12147685
12150892
12193580
12208879
12219085
12426389
12438448
12444555
12466851
12526039
12540842
12571365
12594516
12628925
12634107
12691915
12727921
12738762
12743296
12746441
12748279
12753872
12810593
12826573
12832402
12842895
12907458
14525952
14527166
14566054
14623907
14634136
14636556
14657276
14660441
14670306
14673160
14673173
14688356
14702106
14716305
14729509
14729671
14737107
14764608
14764630
14975238
14978477
14996842
15021879
15037656
15044588
15069015
15070774
15188379
15192020
15194489
15207851
15208705
15218058
15226823
15251981
15254021
15278897
15284232
15292206
15306216
15343379
15343391
15356132
15358102
15366002
15467733
15485908
15541348
15561935
15572665
15582129
15607729
15618518
15632011
15634877
15640156
15647843
15650055
15659653
15664994
15671148
15673499
15673569
15688008
15688401
15694417
15705584
15730854
15735683
15735720
15749075
15749841
15761497
15761498
15778348
15781265
15782199
15790774
15793565
15838885
15893881
15895073
15917293
15919823
15923602
15936723
15964802
15970507
15976028
15978261
15991029
15994947
15996112
15998795
16014896
16026757
16041381
16046413
16054060
16107692
16116228
16141072
16141073
16141211
16174774
16192306
16212920
16230418
16285960
16286017
16288283
16289036
16293640
16298512
16368885
16377083
16388483
16417589
16418226
16452166
16581004
16601124
16634641
16636663
16647058
16679075
16702165
16709597
16713992
16717113
16718380
16720575
16728475
16737695
16751181
16783372
16787943
16788692
16825489
16829633
16888100
16939807
16959875
16971418
16982690
16988490
17015723
17023536
17028185
17030178
17077290
17078929
17082570
17095713
17202473
7512451
7523373
7545930
7568080
7579387
7681397
8140422
8530075
8626752
8631837
8670868
8675499
8692794
8692797
8782827
8833906
8889548
8918689
8942998
9022056
9108058
9119818
9287210
9342212
9464852
9497331
9630560
9638363
9695817
9794394
9874564
10037026
10446219
10464281
10490649
10506573
10521505
10570284
10602027
10688651
10764767
10809230
10825200
10875894
10878010
10918587
10925297
10954736
10982829
11021801
11134330
11163768
11171987
11279133
11294897
11335711
11350938
11418668
11429412
11438698
11463827
11470914
11536047
11585385
11594781
11722592
11751884
11751994
11773079
11809683
11815625
11827956
11843291
11856732
11859072
11861277
11861839
11882364
11923478
11929748
11940567
11940572
11959895
11960372
11987152
12023369
12039028
12060494
12061840
12067972
12070153
12105218
12168776
12193474
12235142
12244095
12359225
12361954
12389630
12393476
12396456
12444102
12444174
12466961
12506013
12531804
12545153
12547716
12551922
12555068
12556536
12559950
12562765
12576423
12600988
12615922
12623850
12626508
12629155
12629515
12637318
12637586
12640143
12670499
12707028
12748293
12763138
12777975
12782602
12789269
12804609
12821944
12833138
12846741
12865928
12865943
12867595
12873986
12900415
12947115
12960275
12963127
12969979
14515142
14522952
14551213
14593105
14647442
14672334
14674010
14688368
14701810
14702039
14712222
14715251
14715258
14736711
14963038
14966128
15034082
15064716
15070700
15077160
15141228
15143062
15145953
15150111
15156153
15161657
15162527
15163742
15165826
15184909
15194868
15198092
15207733
15223310
15229229
15242774
15254691
15277698
15284113
15286705
15297310
15336564
15378007
15465816
15474458
15476590
15530426
15575898
15588985
15590419
15604419
15615703
15629435
15643501
15649887
15650183
15653507
15665295
15677474
15682485
15688010
15703780
15735682
15735721
15736426
15764709
15809078
15837065
15845643
15870198
15878791
15882975
15894558
15905571
15912144
15935090
15936715
15944400
15950906
15958548
15979846
16007214
16036105
16061629
16061651
16081048
16082218
16098628
16125646
16140268
16142329
16192633
16236134
16236267
16278387
16331268
16382134
16407171
16425286
16432158
16503733
16512876
16524883
16557588
16568091
16571725
16619044
16636048
16651533
16709613
16732314
16807407
16825495
16828865
16835372
16840717
16861352
16871275
16877361
16887796
16926159
16935931
16948814
16959370
16984731
17008315
17012261
17015686
3031469
7624343
7719938
8272872
8608603
8626374
8626489
8631962
8657134
8921406
8923468
9162009
9211920
9343414
9373245
9388192
9398404
9440692
9484840
9566874
9584171
9647732
9670957
9714332
9864141
9872331
9917912
9923604
9989503
12419823
12637510
16257644
11076863
15194700
15489334
15489336
15592455
15951569
15994929
16381901
16685378
16841088
16904741
16946298
17078813
17142261
17145757
17151100
17182572
17194701
17203226
17204573
17209045
17220301
17241887
17276988
17289576
17311011
17318196
17341611
17341659
17344214
17360477
17374439
17376889
17379849
17404258
17438134
17459060
17460772
17463090
17531096
17533050
17543278
17543500
17545518
17597020
17602083
17603019
17616678
17634553
17676033
17689208
17824789
7701321
12704203
17082315
17089128
17113145
17131407
17161614
17198696
17202361
17204554
17227828
17233738
17234735
17241879
17256754
17277312
17353274
17360716
17363300
17363460
17404271
17452461
17475846
17485440
17493959
17509611
17525280
17562326
17581537
7543024
9671298
17031671
17322172
17326204
17464217
17487688
17498643
17611279
10441580

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 11 63.82 cM
11 60.5 cM

OMIM ID 102582
615952
147060

Rat chromosome position 10q31
10q32.1

Hugo ID 11364
HGNC:11364

Human chromosome position 17q21.2
17q21.31
4q21

Swiss-Prot Accession P40763
P40763.2
Q6GU23
P42227
Q3ULI4
P42227.2
P52631
P52631.1
A8K7B8
K7ENL3
O14916
Q9BW54
A2A5D1
B7ZC17
Q9BXH2
Q3U5Q4
Q3U6S9
Q8CFJ6
Q99ML3
STAT3_HUMAN
STAT3_MOUSE
STAT3_RAT
A2A5D1_MOUSE
B7ZC17_MOUSE
Q6GU23_MOUSE
Q8N2X9

PIR ID A54444
I49508

GenBank ID NC_000017
XM_017024973
XP_016880462
NM_001369519
NP_001356448
NM_003150
NP_003141
NM_001369517
NP_001356446
NM_001369512
NP_001356441
NM_001369514
NP_001356443
NM_001369518
NP_001356447
NM_001369513
NP_001356442
NM_001369520
NP_001356449
NM_001369516
NP_001356445
NM_213662
NP_998827
NM_139276
NP_644805
XM_024450896
XP_024306664
NG_007370
AC087691
AC107993
AF332508
AAK17196
AY572796
AAS66986
CH471152
EAW60820
EAW60821
EAW60822
EAW60823
EAW60824
EAW60825
EAW60826
EAW60827
HI961665
CBY84972
JA362592
CCA94578
JX296640
JX296641
JX296642
JX296643
JX296644
JX296645
JX296646
JX296647
JX296648
JX296649
JX296650
JX296651
JX296652
JX296653
JX296654
JX296655
JX296656
JX296657
JX296658
JX296659
JX296660
JX296661
JX296662
JX296663
JX296664
JX296665
JX296666
JX296667
JX296668
JX296669
JX296670
JX296671
JX296672
JX296673
JX296674
JX296675
JX296676
JX296677
JX296678
JX296679
AB451232
BAG70046
AF029311
AAB84254
AI631896
AJ012463
CAA10032
AK024535
AK092965
AK291933
BAF84622
AK297994
BAG60302
AK301200
BAG62778
AK316139
BAH14510
BC000627
AAH00627
BC008044
BC014482
AAH14482
BC029783
BC067119
BC107775
BI461226
CB216860
CB321646
CF454565
L29277
AAA58374
P40763
NC_000077
NM_213660
NP_998825
NM_011486
NP_035616
NM_213659
NP_998824
XM_011248846
XP_011247148
XM_017314401
XP_017169890
AB008160
AF246978
AAL59017
AF332507
AAK17195
AL591466
DS033677
EDL01234
AA123454
AK004083
AK079406
AK145486
BAE26464
AK153005
BAE31645
AK153170
AK153472
BAE32023
AK161906
AK184281
AK192932
AK192951
AK193746
AK197148
AY299489
AAQ75418
AY299490
AAQ75419
BC003806
AAH03806
BC019168
AAH19168
BC037688
AAH37688
BY301717
L29278
AAA37254
U06922
AAA19452
U08378
AAA56668
U30709
AAC52612
P42227
NC_005109
XM_006247259
XP_006247321
XM_006247257
XP_006247319
XM_006247258
XP_006247320
NM_012747
NP_036879
AC_000078
AAHX01066019
AC117979
CH473948
EDM06069
BC087025
AAH87025
FQ223504
FQ225489
GU477503
GU477504
X91810
CAA62920
P52631
XM_017024972
XM_017024976
XM_017024974
XM_017024975
XP_005257673
XP_005257674
XP_011523447
XP_011523448
XM_011525146
XM_011525145
XP_016880463
XP_016880461
XP_016880465
XP_016880464
XM_005257616
XM_005257617
NW_001072672
ABZ92186
AAHY01199405
AC_000149
XP_005257677
XP_005257670
XP_005257671
XP_005257672
XP_005257675
XP_005257676
AC_000033
AAHY01149956
ABBA01006426
ABBA01006427
AABR06065579
ABBA01006428
AABR06065578
NC_018928
ACE86450
AM393108
CAM19460
CAM19461
AMYH02033429
NW_001076646
ACE87126
AMYH02033428
EU831531
EU446657
EU831439
XM_005257613
CAX15621
CAX15620
XM_005257614
XM_005257615
XM_005257618
XM_005257619
AAHY01095762
CAL37986
XM_005257620
NT_010783
NW_001838436
NW_926828
AC_000060
Q9BXH2
NT_165773
NW_001030432
Q3U5Q4
Q3U6S9
Q3ULI4
Q6GU23
Q8CFJ6
Q99ML3
NW_047339
NW_001084656
NT_096143
NT_010755
AAH29783
Q8N2X9
NT_096135
XP_001005155
XM_907398
AI325183
XM_001005155
BI079838
BG076355
NW_000040
1107849
1711554
56268829
1166506
123794241
123794262
123794726
13272530
13277852
1711553
17512414
18087726
22902299
34559408
34559410
458706
473890
476716
74151969
74211440
74225465
81867865
81878009
81886328
AW109958
119581226
119581227
119581228
12653685
13272532
15680254
20987437
2613014
3850050
45505190
475789
48429227
74717617
74728735
NT_086877
XP_912491
44804293
44804295
44804297
44804303
44804305
44804309
44804311
44804313
44804317
48428571
8249012
AJ276489
AJ620655
AJ620656
AJ620657
AJ620660
AJ620661
AJ620663
AJ620664
AJ620665
AJ620667
CAB93140
CAF06182
CAF06183
CAF06184
CAF06187
CAF06188
CAF06190
CAF06191
CAF06192
CAF06194
P61635
122143993
44804299
44804301
44804307
44804315
75044935
75044936
75044937
75044938
75044939
75044940
75044941
75044942
75044943
75044944
75050657
75053153
81674209
AAI09482
AJ620658
AJ620659
AJ620662
AJ620666
BC109481
CAF06185
CAF06186
CAF06189
CAF06193
NC_007317
NM_001012671
NP_001012689
NW_001493680
Q32LP6
Q704V9
Q704W0
Q704W1
Q704W2
Q704W3
Q704W4
Q704W5
Q704W6
Q704W7
Q704W8
Q704W9
Q9N0J4
AI641458
AI657582
BF157016
BG307556
NC_007114
NW_001513072
XM_001333647
XP_001333683
117645040
119581224
119581225
119581229
119581230
119581231
123239571
123239572
148669287
149054252
P40763-2

Swiss-Prot ID STAT3_HUMAN
STAT3_MOUSE
STAT3_RAT
Q6GU23_MOUSE
A2A5D1_MOUSE
B7ZC17_MOUSE

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000168610
ENSP00000384943.3
ENST00000404395.3
ENSP00000264657.4
ENST00000264657.9
ENSMUSG00000004040
ENSMUSP00000099403.1
ENSMUST00000103114.7
ENSMUSP00000120152.1
ENSMUST00000127638.7
ENSMUSP00000090342.5
ENSMUST00000092671.11
ENSRNOG00000019742
ENSRNOP00000026760.3
ENSRNOT00000026760.4
ENSP00000467985.1
ENSP00000467000.1
ENST00000588969.5
ENST00000585517.5
ENSMUSP00000090342
ENSMUSP00000120152
ENSP00000384943
ENSMUST00000103114
ENSP00000467000
ENSP00000467985
ENSRNOP00000026760
ENST00000404395
ENSP00000264657
ENSMUSP00000099403
ENSMUST00000092671
ENST00000264657
ENST00000585517
ENST00000588969
ENSRNOT00000026760
ENSMUST00000127638

MGI ID MGI:103038
103038
1915983
2144497

RGD ID 3772

Unigene ID Rn.10247
Hs.463059
Mm.473190
Mm.249934
Mm.277403
Hs.643543
Hs.567649
Bt.15334

Homologene ID 7960

Shape O-vertex

IPI ID IPI00753792
IPI00306436
IPI00227814
IPI00228955
IPI00208224
IPI00784414
IPI00412752

Microarray ID 99099_at
99100_at
208992_s_at

Homo sapiens Chromosome position 17q21.31
4q21

Ensembl Transcript ID ENST00000389272
ENST00000264657
ENST00000404395

ENSEMBL ENSG00000168610

FunctionalClass DNA binding
hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer
protein binding
protein dimerization
transcription factor
transcription factor binding
transcriptional activator
calcium ion binding
signal transducer
transcription activator

Bos taurus Chromosome position 19

Mus musculus Chromosome position 11 60.5 cM
11

KEGG pathway Jak-STAT signaling pathway

ProteinAtlas SubcellularLocation Main location: Nucleus but not nucleoli;Cytoplasm; Other location: ; Expression type: Staining; Reliability: Supportive

Rattus norvegicus Chromosome position 10q32.1

Ensembl Gene ID ENSG00000168610

ProteinAtlas NormalTissue Tissue: fallopian tube; Cell type: glandular cells; Level: High; Expression type: APE; Reliability: High
Tissue: kidney; Cell type: cells in tubules; Level: Medium; Expression type: APE; Reliability: High
Tissue: lung; Cell type: pneumocytes; Level: High; Expression type: APE; Reliability: High
Tissue: stomach
lower; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: spleen; Cell type: cells in white pulp; Level: None; Expression type: APE; Reliability: High
Tissue: uterus
pre-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: prostate; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: seminal vesicle; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: kidney; Cell type: cells in glomeruli; Level: Medium; Expression type: APE; Reliability: High
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: ovary; Cell type: ovarian stroma cells; Level: Low; Expression type: APE; Reliability: High
Tissue: skeletal muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: High
Tissue: adrenal gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: appendix; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: appendix; Cell type: lymphoid tissue; Level: Medium; Expression type: APE; Reliability: High
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Low; Expression type: APE; Reliability: High
Tissue: breast; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: cells in granular layer; Level: Low; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Low; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: Purkinje cells; Level: Low; Expression type: APE; Reliability: High
Tissue: cerebral cortex; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Low; Expression type: APE; Reliability: High
Tissue: cervix, uterine; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: colon; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: duodenum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: epididymis; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: gall bladder; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: heart muscle; Cell type: myocytes; Level: Low; Expression type: APE; Reliability: High
Tissue: hippocampus; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: hippocampus; Cell type: neuronal cells; Level: Low; Expression type: APE; Reliability: High
Tissue: lateral ventricle; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Low; Expression type: APE; Reliability: High
Tissue: liver; Cell type: bile duct cells; Level: Low; Expression type: APE; Reliability: High
Tissue: liver; Cell type: hepatocytes; Level: None; Expression type: APE; Reliability: High
Tissue: lung; Cell type: macrophages; Level: Medium; Expression type: APE; Reliability: High
Tissue: lymph node; Cell type: germinal center cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: lymph node; Cell type: non-germinal center cells; Level: Low; Expression type: APE; Reliability: High
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: pancreas; Cell type: islets of Langerhans; Level: Medium; Expression type: APE; Reliability: High
Tissue: parathyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: placenta; Cell type: decidual cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: placenta; Cell type: trophoblastic cells; Level: Low; Expression type: APE; Reliability: High
Tissue: rectum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: salivary gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: skin; Cell type: epidermal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: small intestine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: None; Expression type: APE; Reliability: High
Tissue: spleen; Cell type: cells in red pulp; Level: Low; Expression type: APE; Reliability: High
Tissue: stomach, lower; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: stomach, upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Medium; Expression type: APE; Reliability: High
Tissue: testis; Cell type: Leydig cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: thyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: germinal center cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: non-germinal center cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: urinary bladder; Cell type: urothelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Medium; Expression type: APE; Reliability: High
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Medium; Expression type: APE; Reliability: High
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: vagina; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High

LocatorString gscquery:curcumin+prostate+cancer
pmftq:achondroplasia
pmquery:egfr+transactivation

Danio rerio Chromosome position LG 3