Protein PTK2

URN urn:agi-llid:5747
Total Entities 1
Connectivity 8007
Name PTK2
Description protein tyrosine kinase 2
Notes This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

ChildConcepts FRNK

Pathway Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Platelet Activation via Adhesion Molecules
Eat me Signal: Apoptotic Cell Induces Phagocytosis
Neutrophil Activation via Adherence on Endothelial Cells
Vascular Endothelial Cell Permeability Activation
CHRNA7 -> NOS1 Production
EPHB -> NMDA Receptor Activation
G0/G1 Phase Transition
Focal Junction Assembly
Proteins Involved in Dilated Cardiomyopathy
Proteins Involved in Arterial Hypertension
Proteins Involved in Myocardial Ischemia
Proteins with Altered Expression in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
Dedifferentiation and Metastatic Progression in Melanoma
Proteins Involved in Melanoma
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
Proteins Involved in Diabetic Nephropathy
Proliferative Diabetic Retinopathy
RET1 Mutation in Hyperparathyroidism
Cardiovascular Effects in Hyperthyroidism
Myocyte Dysfunction in Hypoparathyroidism
Metastatic Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Independent Signaling
CagA Phosphorylation Dependent Signaling
Proteins Involved in Hepatocellular Carcinoma
Proteins Involved in Pancreatic Cancer
Goblet-Cell Exocytosis in Asthma
Neutrophil Degranulation via FPR1/IL8
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
WHIM Syndrome
Macrophage Survival through CCR5 and CXCR4 Mediated Signaling
Cowden Syndrome
Ca2+ Overload in Muscular Dystrophies
Muscular Dystrophies
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies
Glioma Invasion Signaling
Proteins Involved in Glioma
Ependymoma
Proteins Involved in Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
Proteins Involved in Prostate Cancer
Proteins Involved in Cataract
VEGFA in Neovascular Glaucoma
CD157/ITGB2 Signaling in Myeloid Cell
Acetylcholine Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
Elevated Receptors -> Expression Targets in Bone
CHRNA7 -> CREB Signaling
NCAM1 Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
Receptors and Adaptor Proteins Activated in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
G0/G1 Cell Cycle Phase Transition Activation in Cancer
HIF1A in Vasculogenic Mimicry of Cancer
ANGPT/TEK Stimulates Endothelial Cell Migration in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
Proteins with Altered Expression in Cancer Metastases
Epithelial to Mesenchymal Transition in Cancer: Overview
BSG (CD147) in Cancer Cells Motility, Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
Lipogenesis/Lipolysis Activation in Cancer Cells and Cancer-Associated Adipocytes
NCAM1 -> CREB/ELK/SRF/MYC Signaling
FibronectinR -> CTNNB Signaling
FibronectinR -> NF-kB Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
EphrinB -> Cytoskeleton Signaling
EphrinB -> MAPK/JUN/FOS Signaling
FOXO1 Signaling
MERTK Signaling
PI3K/RAC1 Signaling
VEGF Signaling
EGFR Signaling
ERK5/MAPK7 Signaling
ERK/MAPK Canonical Signaling
VEGFC -> CTNNB Expression Target
VEGFA -> STAT Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
VEGFR -> CTNNB Signaling
VEGFR -> STAT Signaling
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
Possible Interplay between SOX11, CCND1 and EZH2 in Mantle Cell Lymphoma
3_Enhanced angiogenesis in endometriosis
2_Pathogens stimulate mucins expression in the middle ear
3_1_Mucus accumulation in asthma
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_1_General pathways of thyroid hormone signaling
Model of PPARG signaling in psoriais (tested)

Group Proteins Involved in Cowden Syndrome

MedScan ID 5747

LocusLink ID 5747
14083
25614

Alias PTK2 protein tyrosine kinase
focal adhesion kinase p125
PTK-2
Focal adhesion kinase I
FAK
FADK
p125FAK
PTK2
focal adhesion kinase
FAK I
mKIAA4203
PTK2 protein tyrosine kinase 2
PPP1R71
FADK I
focal ashension kinase 1
FADK 1
pp125FAK
protein tyrosine kinase 2
Focal adhesion kinase 1
protein phosphatase 1, regulatory subunit 71
FAK1
focal adhesion kinase isoform FAK-Del33
PTK2 protein tyrosine kinase II
KIAA4203
FRNK
FAK-related non-kinase polypeptide
focal adhesion kinase-related nonkinase
protein phosphatase 1 regulatory subunit 71
protein-tyrosine kinase 2
FAK-related non kinase polypeptide
FAK-related nonkinase polypeptide

EC Number 2.7.10.2

GO ID 0005524
0008432
0042169
0003779
0004715
0004672
0019901
0019903
0004713
0038096
0000165
0001525
0007411
0030154
0048870
0021955
0043542
0048013
0007173
0030010
0030198
0060396
0003007
0007229
0000226
2000811
0043066
0010507
0050771
0022408
0046621
0051964
0038007
0001764
0007097
0038083
0018108
0001890
0010613
0030335
0008284
0043552
0014068
0051897
0045860
0001934
2000060
0046777
0043087
0030155
0033628
0042127
0008360
0051493
0010594
0010632
0051893
0045667
0001932
1900024
0007172
0007179
0048010
0001570
0005912
0016324
0005938
0005737
0005856
0005829
0043197
0005925
0030027
0005815
0005634
0005886
0001725
0005178
0016301
0000166
0019902
0043548
0044877
0016740
0031625
0007254
0001568
0030644
0071560
0007275
0030336
0016310
0097755
0045785
0030307
0060252
0050766
0014911
0048661
0050806
0006468
0016323
0030054
0098978
0014704
0016020
0016604
0005730
0098794
0042383
0045444
0046685
0042493
0032355
0009749
0009612
0014070
0010033
0010243
0048471
0045087
0031234
0005102
0032319
0005515
0009790
0007010
0004871
0040023
0007596
0032403
0006915
0043547
0007165
0007169
0006921
0006928
0030168
0016772
0005088
0045909
0007155

KEGG ID hsa:5747
mmu:14083
rno:25614

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 15 33.94 cM
15 42.0 cM

OMIM ID 600758

Rat chromosome position 7q34

Hugo ID 9611
HGNC:9611

Human chromosome position 8q24.3

Swiss-Prot Accession Q05397
Q59GM6
Q658W2
Q59GN8
Q05397.2
P34152
K7Q751
P34152.4
O35346
O35346.1
B4E2N6
F5H4S4
J3QT16
Q14291
Q8IYN9
Q9UD85
O08578
Q5DTH7
Q8C513
Q8CFH7
Q8CHM2
Q8K2S0
Q9DAW3
Q62900
P34152.3
R9PXT6
E7ESA6

PIR ID I53012
PC1225
A46166

GenBank ID NC_000008
NR_148039
NR_148038
NR_148036
NR_148037
NM_001352699
NP_001339628
NM_001352746
NP_001339675
NM_001352742
NP_001339671
NM_001352745
NP_001339674
NM_001352744
NP_001339673
NM_001352741
NP_001339670
NM_001352738
NP_001339667
NM_001316342
NP_001303271
NM_001352733
NP_001339662
NM_001352734
NP_001339663
NM_001352732
NP_001339661
NM_001352730
NP_001339659
NM_001352728
NP_001339657
NM_001352729
NP_001339658
NM_001352711
NP_001339640
NM_001352694
NP_001339623
NM_001352720
NP_001339649
NM_001352713
NP_001339642
NM_001352715
NP_001339644
NM_001352727
NP_001339656
NM_001352721
NP_001339650
NM_001352706
NP_001339635
NM_001352747
NP_001339676
NM_001352700
NP_001339629
NM_001352736
NP_001339665
NM_001352740
NP_001339669
NM_001352743
NP_001339672
NM_001352696
NP_001339625
NM_001352731
NP_001339660
NM_001352726
NP_001339655
NM_001352716
NP_001339645
NM_153831
NP_722560
NM_001352718
NP_001339647
NM_001199649
NP_001186578
NM_001352714
NP_001339643
NM_001352717
NP_001339646
NM_001352723
NP_001339652
NM_001352724
NP_001339653
NM_001352709
NP_001339638
NM_001352695
NP_001339624
NM_001352704
NP_001339633
NM_001352702
NP_001339631
NM_001352701
NP_001339630
NM_001352735
NP_001339664
NM_001352719
NP_001339648
NM_001352722
NP_001339651
NM_001352708
NP_001339637
NM_001352725
NP_001339654
NM_001352739
NP_001339668
NM_001352707
NP_001339636
NM_001352703
NP_001339632
NM_001352712
NP_001339641
NM_001352737
NP_001339666
NM_005607
NP_005598
NM_001352697
NP_001339626
NM_001352705
NP_001339634
NM_001352698
NP_001339627
NM_001352710
NP_001339639
NM_001352752
NP_001339681
NM_001352751
NP_001339680
NM_001352750
NP_001339679
NM_001352749
NP_001339678
XM_024447210
XP_024302978
XM_024447207
XP_024302975
XM_024447206
XP_024302974
XM_024447205
XP_024302973
XM_024447203
XP_024302971
XM_017013666
XP_016869155
XM_017013669
XP_016869158
XM_024447202
XP_024302970
XM_017013656
XP_016869145
XM_017013688
XP_016869177
XM_017013684
XP_016869173
XM_024447211
XP_024302979
XM_024447209
XP_024302977
XM_024447208
XP_024302976
XM_024447200
XP_024302968
XM_024447199
XP_024302967
XM_017013654
XP_016869143
XM_017013653
XP_016869142
XM_024447212
XP_024302980
XM_017013664
XP_016869153
XM_024447204
XP_024302972
XM_024447201
XP_024302969
XM_017013657
XP_016869146
NM_001352748
NP_001339677
NG_029467
AC067931
AC100860
AC105009
AC105235
AY323812
CH471060
EAW92210
EAW92211
EAW92212
EAW92213
EAW92214
KF458878
KF458882
AB209071
BAD92308
AB209083
BAD92320
AK055139
AK094999
BAC04470
AK124810
AK294873
BAG57974
AK301557
BAG63053
AK304356
BAG65198
AL832961
CAH56296
BC015361
BC028733
AAH28733
BC035404
AAH35404
BC043202
BF434494
BY800117
DA236314
DA994616
DB478006
KF437463
AHZ89389
L13616
AAA58469
Q05397
NC_000081
XM_006520426
XP_006520489
XM_006520430
XP_006520493
XM_006520431
XP_006520494
XR_383981
XM_006520435
XP_006520498
XM_006520424
XP_006520487
XM_006520416
XP_006520479
XM_006520425
XP_006520488
XM_006520415
XP_006520478
XM_006520429
XP_006520492
XM_006520428
XP_006520491
XM_006520427
XP_006520490
XM_006520434
XP_006520497
XM_017316429
XP_017171918
XM_006520433
XP_006520496
XM_006520423
XP_006520486
XM_006520422
XP_006520485
XM_006520421
XP_006520484
XM_006520420
XP_006520483
XM_006520418
XP_006520481
XM_011245453
XP_011243755
NM_007982
NP_032008
XM_006520432
XP_006520495
XM_017316428
XP_017171917
XM_011245452
XP_011243754
NM_001130409
NP_001123881
XR_001781493
NM_001358045
NM_001358046
AC121319
AC132863
AC161581
AH005806
AAB95262
AAB95263
CH466545
EDL29415
EDL29416
EDL29417
EDL29418
U77074
AAB51229
U77075
AAB51230
U77076
AAB51231
AB011499
BAC53890
AB030035
BAC53924
AK005468
BAB24058
AK052252
AK079821
BAC37757
AK135490
AK220543
BAD90317
AY916078
AAY16304
BB816209
BC030180
BU512211
BY297123
CJ050166
DQ478404
ABF47284
DQ478405
ABF47285
DQ478406
ABF47286
DQ478407
ABF47287
JN971016
AFR23585
M95408
AAA37592
U15088
P34152
NC_005106
XM_017594678
XP_017450167
NM_013081
NP_037213
AC_000075
AABR07058402
AABR07058403
AAHX01051533
AAHX01051534
AAHX01051535
CH473950
EDM16117
EDM16118
EDM16119
AF020777
AAB72203
AI717382
CA508631
CA511845
CB713440
EV773243
U43940
AAA86278
U43941
AAA86279
U43942
AAA86280
O35346
XM_011517184
XM_011517185
ABW03595
XM_011517186
XM_011517187
XM_011517188
XM_011517189
XM_011517180
XM_011517181
XM_011517182
XM_011517183
XP_011515483
XP_011515482
XP_011515489
XP_011515488
XP_011515485
XP_011515484
XP_011515487
XP_011515486
XP_011515492
XP_011515491
XP_011515494
XP_011515493
XP_011515490
XP_011515499
XP_011515496
XP_011515495
XP_011515498
XP_011515497
XP_006716669
XM_008765546
XP_006716673
XP_006716672
XP_006716671
AMYH02018889
AMYH02018888
XP_006716670
XM_011517195
XM_011517196
XM_011517197
XM_011517198
AMYH02018890
AAHY01123319
AMYH02018892
AMYH02018891
AMYH02018894
AMYH02018893
XM_011517190
AMYH02018895
XM_011517191
XM_011517192
XM_011517193
XM_011517194
AAHY01123323
AAHY01123321
AAHY01123322
AAHY01123320
XP_005251067
XP_005251066
XP_005251069
XP_005251068
XP_005251063
XP_005251062
XP_005251065
XP_005251064
XP_005251061
XP_005251060
XP_008763768
ABBA01013677
ABBA01013679
ABBA01013678
XP_005251070
XP_005251071
AF025650
AF025651
AF025652
AF025648
AF025649
XP_006241787
XP_006520482
XP_006520480
XM_006241725
XM_006520417
XM_006520419
AC_000037
AABR06051811
AABR06051812
AABR06051810
XM_005251013
XM_005251012
XM_005251011
XM_005251010
XM_006716609
XM_006716608
XM_006716607
XM_006716606
XM_005251014
NC_018919
XM_005251009
XM_005251008
XM_005251007
XM_005251006
XM_005251005
XM_005251004
XM_005251003
XM_006716610
XP_011515500
EU176794
AC_000140

Swiss-Prot ID FAK1_HUMAN
FAK1_MOUSE
FAK1_RAT

Cell Localization Cell junction
Focal adhesion
Cell membrane
Cytoplasm
Cell cortex
Cytoskeleton
Microtubule organizing center
Centrosome
Nucleus
Perinuclear region
Cytoplasm, cell cortex
Cytoplasm, cytoskeleton
Cytoplasm, perinuclear region
Cell junction, focal adhesion
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Ensembl ID ENSG00000169398
ENSP00000341189.3
ENST00000340930.7
ENSP00000429474.1
ENST00000521059.5
ENSP00000428492.1
ENST00000523539.5
ENSP00000429170.1
ENST00000519465.5
ENSP00000403416.2
ENST00000430260.6
ENSP00000429911.1
ENST00000522684.5
ENST00000519993.5
ENSP00000429082.1
ENST00000517887.5
ENSP00000429129.1
ENST00000519419.5
ENSMUSG00000022607
ENSMUSP00000105663.2
ENSMUST00000110036.10
ENSMUSP00000154242.1
ENSMUST00000226988.2
ENSRNOG00000007916
ENSRNOP00000011219.6
ENSRNOT00000011219.6
ENSRNOP00000075518.1
ENSRNOT00000079599.1
ENSMUSP00000105663
ENSMUST00000110036
ENSP00000341189
ENSRNOP00000075518
ENST00000522684
ENSMUST00000170939
ENSMUSP00000126764
ENSP00000429911
ENSRNOP00000011219
ENSP00000429082
ENSRNOT00000011219
ENSRNOT00000079599
ENST00000517887
ENST00000340930

MGI ID MGI:95481
95481

RGD ID 3443

Unigene ID Rn.2809
Hs.395482
Mm.254494

Homologene ID 7314

Shape Sickle-vertex

IPI ID IPI00875543
IPI00895396
IPI00338858
IPI00982478
IPI00476238
IPI00216218
IPI00216217
IPI00973349
IPI00895208
IPI00625418
IPI01011193
IPI00113563
IPI00230629
IPI00895269