URN | urn:agi-llid:8767 |
---|---|
Total Entities | 0 |
Connectivity | 956 |
Name | RIPK2 |
Description | receptor interacting serine/threonine kinase 2 |
Notes | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008] |
Primary Cell Localization | Cytoplasm |
Class | Protein kinase |
ObjectType | Protein |
Pathway | NOD-like Receptors |
---|---|
Crohn's Disease | |
Paneth-Cell Function in Crohn's Disease | |
Macrophage Dysfunction | |
Dendritic Cell Dysfunction in Crohn's disease | |
CagA Phosphorylation Independent Signaling | |
Dendritic Cell Function in Ulcerative Colitis | |
Blau Syndrome | |
Proteins Involved in Huntington Disease | |
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes | |
Model of PPARG signaling in psoriasis | |
Model of PPARG related pathways in psoriasis (short version) | |
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media | |
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD | |
1_Th2 cell response in asthma | |
2_Paneth cell dysfunction in Crohn's disease | |
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease | |
3_Autophagy dysfunction in Crohn's disease | |
2_Intestine epithelial cells drive immunological responses in ulcerative colitis | |
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D | |
mapk1 protein modificators |
MedScan ID | 8767 |
---|
LocusLink ID | 8767 |
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192656 | |
362491 |
Alias | CARDIAK,CCK,RICK,RIP |
---|---|
RIKEN cDNA 2210420D18 gene | |
receptor interacting protein 2 | |
receptor interactive protein II | |
receptor-interactive serine-threonine kinase 2 | |
RIP-like-interacting CLARP kinase | |
DNA segment, Chr 4, Brigham & Women's Genetics 0615 expressed | |
RP23-378L22.1 | |
CARD-containing IL-1 beta ICE-kinase | |
receptor (TNFRSF)-interactive serine-threonine kinase 2 | |
CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase | |
tyrosine-protein kinase RIPK2 | |
CARD3 | |
2210420D18Rik | |
growth-inhibiting gene 30 | |
GIG30 | |
receptor-interacting serine-threonine kinase 2 | |
RICK | |
OTTMUSP00000004983 | |
CARD-carrying kinase | |
CARDIAKs | |
WUGSC:H_RG437L15.1 | |
receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase | |
D4Bwg0615e | |
CARDIAK | |
receptor (TNFRSF)-interacting serine-threonine kinase II | |
receptor-interactive serine-threonine kinase II | |
(CARD)-containing serine/threonine kinase Rip2 | |
receptor (TNFRSF)-interacting serine-threonine kinase 2 | |
receptor interacting protein II | |
receptor (TNFRSF)-interactive serine-threonine kinase II | |
receptor interactive protein 2 | |
CARD-containing interleukin-1 beta-converting enzyme-associated kinase | |
2210420D18 | |
RIP serine threonine kinase 2 | |
RIPK2 | |
RIP2 | |
receptor-interacting serine-threonine kinase II | |
CCK | |
RIP-2 | |
receptor-interacting protein 2 | |
receptor-interacting serine/threonine-protein kinase 2 |
EC Number | 2.7.10.2 |
---|---|
2.7.11.1 |
GO ID | 0005524 |
---|---|
0050700 | |
0004706 | |
0030274 | |
0089720 | |
0004715 | |
0042803 | |
0004674 | |
0005102 | |
0007249 | |
0007254 | |
0000165 | |
0042098 | |
0050852 | |
0007256 | |
0007257 | |
0000187 | |
0097202 | |
0002250 | |
0006915 | |
0071223 | |
0071225 | |
0071224 | |
0050830 | |
0006954 | |
0045087 | |
0070498 | |
0031663 | |
0043066 | |
0070427 | |
0070431 | |
0070423 | |
0018108 | |
0070374 | |
0043123 | |
0051092 | |
0045627 | |
0046641 | |
0043065 | |
0010942 | |
0032722 | |
0001961 | |
0033091 | |
0032727 | |
0032728 | |
0032729 | |
0050718 | |
0032735 | |
0032743 | |
0032755 | |
0033138 | |
0010800 | |
0050731 | |
0032092 | |
0031398 | |
0045944 | |
0032760 | |
1904417 | |
0043330 | |
0070671 | |
0070673 | |
0007165 | |
0034134 | |
0034142 | |
0005737 | |
0005856 | |
0005829 | |
0032991 | |
0031982 | |
0016301 | |
0000166 | |
0004672 | |
0016740 | |
0071222 | |
0002376 | |
0016310 | |
0046330 | |
0002827 | |
0032874 | |
0006468 | |
0042981 | |
0043281 | |
0070555 | |
0004871 | |
0043234 | |
0002755 | |
0002756 | |
0035666 | |
0008063 | |
0048011 | |
0035872 | |
0051403 | |
0034130 | |
0034138 | |
0002224 | |
0016772 | |
0005622 | |
0006916 | |
0004872 | |
0034166 | |
0034146 | |
0034162 | |
0038123 | |
0038124 |
KEGG ID | hsa:8767 |
---|---|
mmu:192656 | |
rno:362491 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 4 6.7 cM |
---|---|
4 5.4 cM |
OMIM ID | 603455 |
---|
Rat chromosome position | 5q13 |
---|
Hugo ID | 10020 |
---|---|
HGNC:10020 |
Human chromosome position | 8q21.3 |
---|---|
8q21 |
Swiss-Prot Accession | A0A0S2Z4Z8 |
---|---|
O43353 | |
O43353.2 | |
P58801 | |
Q547H1 | |
P58801.1 | |
G3V783 | |
B7Z748 | |
Q6UWF0 | |
Q2TU65 | |
Q6Q322 | |
Q3B7U0 |
Swiss-Prot ID | RIPK2_HUMAN |
---|---|
RIPK2_MOUSE | |
Q547H1_MOUSE |
Cell Localization | Cytoplasm |
---|
Ensembl ID | ENSG00000104312 |
---|---|
ENSP00000220751.4 | |
ENST00000220751.5 | |
ENSMUSG00000041135 | |
ENSMUSP00000038833.5 | |
ENSMUST00000037035.11 | |
ENSMUST00000183871.1 | |
ENSRNOG00000009389 | |
ENSRNOP00000012963.2 | |
ENSRNOT00000012963.5 | |
ENSP00000220751 | |
ENST00000220751 | |
ENSMUSP00000038833 | |
ENSMUST00000037035 | |
ENSMUST00000183871 | |
ENSRNOP00000012963 | |
ENSRNOT00000012963 |
MGI ID | MGI:1891456 |
---|---|
1891456 |
RGD ID | 1309167 |
---|
Unigene ID | Hs.103755 |
---|---|
Mm.112765 | |
Rn.102179 |
Homologene ID | 37856 |
---|
Shape | Sickle-vertex |
---|
IPI ID | IPI00139382 |
---|---|
IPI00021917 | |
IPI00554774 | |
IPI00816174 | |
IPI00207880 | |
IPI00766118 |