Protein CCR1

URN urn:agi-llid:1230
Total Entities 0
Connectivity 3118
Name CCR1
Description C-C motif chemokine receptor 1
Notes This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor

Pathway CC Chemokine Receptor Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Nociception Expression Targets Signaling
CCR1 Expression Targets
Chemokines Signaling in Atherosclerosis
Proteins Involved in Myocarditis
Osteoclast Activation in Multiple Myeloma
Proteins Involved in Rheumatoid Arthritis
Proteins Involved in Endometriosis
Proteins Involved in Glomerulonephritis
CCL3 Expression Targets
CCL3L1 Expression Target
CCL16 Expression Targets
CCL5 Expression Targets
CCL7 Expression Target
CCL7 Expression Targets
CCL8 Expression Targets
CCL2 Expression Targets
TNF Receptors -> Expression Targets in Lymphoid System and Blood
C5AR1 -> Expression Targets in Lymphoid System and Blood
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
drug-target pairs direct regulation

Group Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis

MedScan ID 1230

LocusLink ID 1230
12768
57301

Alias CKR1_HUMAN
Cmkbr1l I
SCYAR1
CCR1 receptor
CMKBR1
CCR1
RANTES-R
chemokine (C-C) receptor I
chemokine (C-C) receptor 1,-like
CCR1 receptors
CMKR I
LD78 receptor
RANTES receptors
CMKBR I
chemokine receptor CCR1
Ccr1l I
CC-chemokine receptor-1
C-C chemokine receptor 1
C-C chemokine receptor I
Ccr I
LD78 receptors
hCCR1
antigen CD191
chemokine receptors CCR1
LOC57301
chemokine (C-C) receptor 1
CMKR1
RANTES receptor
CKR-1
SCYAR I
CKR I
chemokine (C-C motif) receptor 1
MIP-1 alphaRL I
CC-CKR I
HM145
CD191 antigen
chemokine (C-C motif) receptor I
chemokine (C-C motif) receptor 1-like 1
CD191
chemokine (C-C) receptor 1-like 1
C-C motif chemokine receptor 1
CC-CKR-1
CKR1
MIP1aR
C-C CKR-1
CCR-1
MIP-1alpha-R
macrophage inflammatory protein 1-alpha receptor
C-C chemokine receptor type 1
Mip-1a-R
MIP-1 alpha R
MIP-1 alphaR
macrophage inflammatory protein-1 alpha receptor

GO ID 0019957
0016493
0071791
0035717
0019956
0004950
0004435
0007186
0007187
0006816
0019722
0007155
0060326
0007166
0007267
0006874
0070098
0006935
0019221
0002407
0006887
0006955
0006954
0030502
0010629
0070374
0051928
0030335
0007204
0090026
0045672
0009611
0005737
0009897
0005887
0005886
0004930
0030595
0030099
0045824
0007165
0016021
0016020
0043025
0021549

KEGG ID hsa:1230
mmu:12768

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}

Mouse chromosome position 9 75.05 cM

OMIM ID 601159

Rat chromosome position 8q32

Hugo ID 1602

Human chromosome position 3p21.31

Swiss-Prot Accession P32246
Q5U003
P32246.1
P51675
Q8BMH9
Q8BVW4
P51675.2
Q9JLY8
Q86VA9
Q6ZWR7
Q91VP9

PIR ID A45177
I49339

GenBank ID NC_000003
NM_001295
NP_001286
AC104439
CH471055
EAW64756
EAW64757
AI089760
BC051306
AAH51306
BC064991
AAH64991
BT019908
AAV38711
BT019909
AAV38712
BX337412
CK903574
D10925
BAA01723
L09230
AAA58408
L10918
AAA36543
P32246
NC_000075
NM_009912
NP_034042
AC140491
AC192862
CH466671
EDL37173
U28404
AAA89153
AK031109
BAC27256
AK036597
BAC29500
AK036690
BAC29535
AK076275
BAC36284
BC011092
AAH11092
CT010178
CAJ18386
U29678
AAA86119
P51675
NC_005107
NM_020542
NP_065417
AC_000076
AABR07071821
AAHX01057714
AF119381
AAF34340
CH473954
EDL76748
BC079207
AAH79207

Swiss-Prot ID CCR1_HUMAN
CCR1_MOUSE

Cell Localization Cell membrane

Ensembl ID ENSG00000163823
ENSP00000296140.3
ENST00000296140.4
ENSMUSG00000025804
ENSMUSP00000026911.4
ENSMUST00000026911.5
ENSRNOG00000006715
ENSRNOP00000008772.3
ENSRNOT00000008772.4

MGI ID MGI:104618

RGD ID 708446