Protein IL1B

URN urn:agi-llid:3553
Total Entities 0
Connectivity 18723
Name IL1B
Description interleukin 1, beta
Notes The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway Alzheimer's Disease
Osteoarthritis
Toll-like Receptors Act through MYD88-TIRAP Signaling
NOD-like Receptors
Dectin-1 (CLEC7A) Signaling
TLR4 Signaling in Leukocytes
Th17-Cell Differentiation
Plasmin Effects in Inflammation
Bradykinin Effects in Inflammation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
MC1R in anti-Inflammatory Signaling
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Prostaglandin E2 Receptor Signaling in Neurons
Macrophage Related Iron Uptake and Release
Macrophage M1 Lineage
anti-Inflammatory Function of Macrophage M2 Lineage
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
CNR1/2 -> IL1B/2/4/6/10 Production
IL1B Expression Targets -> Nociception
Proteins Involved in Atherosclerosis
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Inflammatory Reaction in Acne Vulgaris
Proteins Involved in Atopic Dermatitis
Proteins Involved in Psoriasis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 1
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 2
Proteins Involved in Diabetic Neuropathy
Proteins Involved in Insulin Resistance
Proteins Involved in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Nitric Oxide Effects on beta-Cell
Apoptosis of Thyroid Cell in Hashimoto's Thyroiditis
Proteins Involved in Graves Disease
Graves Ophthalmopathy
Proteins Involved in Hypothyroidism
Fatty Acids in Hypertension and Atherosclerosis Development
Adipokines Production by Adipocyte Impaired in Obesity
Proteins Involved in Obesity
CD4+T-Cell Response in Celiac Disease
Crohn's Disease
Paneth-Cell Function in Crohn's Disease
Macrophage Dysfunction
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
Proteins Involved in Helicobacter Infections
Dendritic Cell Function in Ulcerative Colitis
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Proteins Involved in Multiple Myeloma
Proteins Involved in Thrombophilia
Proteins Involved in Pancreatic Cancer
TRPM7/8 in Pancreatic Adenocarcinoma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Antigen-Presenting Cell Role in Asthma
Th17-Cell Differentiation in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Proteins Involved in Cystic Fibrosis
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
Proteins Involved in Gout
Proteins with Altered Expression in Gout
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Proteins Involved in Osteoarthritis
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
FAS Mediated Apoptosis in Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Proteins Involved in Dental Caries
Proteins Involved in HIV Type 1 Infection
Th17-Cell Numbers Reduction in HIV
CD4+ T-Cell Function Decline in HIV
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
Proteins Involved in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
NF-kB Signaling Activation in Huntington Disease
Muscular Dystrophies
Proteins with Altered Expression in Osteoarthritis
Proteins Involved in Osteoporosis
Proteins with Altered Expression in Rheumatoid Arthritis
Microglia Activation in Alzheimer's Disease
Proteins Involved in Alzheimer's Disease
Proteins Involved in Epilepsy
Ketogenic Diet Mechanism (Hypothesis)
Blood-Brain Barrier Disruption in Epileptiform Disorders
HMGB1 and IL1B in Neuroinflammation
ADK Expression Downregulation after Acute Seizures
HMGB1 and IL1B in Neuronal Hyperexcitation
Proteins Involved in Glioblastoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Neuroblastoma
Microglia Activation in Parkinson's Disease
Proteins with Altered Expression in Parkinson's Disease
Proteins Involved in Parkinson's Disease
Proteins with Altered Expression in Amyotrophic Lateral Sclerosis
Proteins Involved in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
Neuroinflammation in Amyotrophic Lateral Sclerosis
Proteins Involved in Multiple Sclerosis
Proteins Involved in Sleep Initiation and Maintenance Disorders
Proteins Involved in Sleep Disorders
Proteins Involved in Adhesion, Migration and Invasion of Endometriotic Cell
Local Estrogen Production in Endometriosis
Proteins Involved in Endometriosis
Proteins with Altered Expression in Endometriosis
Leptin Role in Endometriosis
Proteins Involved in Spontaneous Abortion
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Androgen Receptor/NKX3-1 Signaling
Proteins Involved in Age-Related Macular Degeneration
Proteins Involved in Hearing Loss
Cochlear Inflammation (Noise-Induced)
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Proteins Involved in Bronchiectasis
Alveolar Macrophages Dysfunction in COPD
Proteins Involved in Chronic Obstructive Pulmonary Disease
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins Involved in Glomerulonephritis
Proteins with Altered Expression in Glomerulonephritis
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Proteins with Altered Expression in Pyelonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
HMGB1 Expression Targets
S100B Expression Targets
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Dopamine/Gi Expression Targets
BMP7/BMPR2/ACVR2 Expression Targets
Elevated Receptors -> Expression Targets in Adipose Tissue
Elevated Receptors -> Expression Targets in Joint
CD8 -> ATF/CREB/CREBBP Expression Targets
CD8 -> STAT Expression Targets
CXCL3 Expression Targets
CXCL12 Expression Targets
CSF2 -> STAT Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF18 -> STAT Expression Targets
FGF18 -> AP-1/CREB Expression Targets
VIP Expression Targets
Elevated Receptors -> Expression Targets in Small Intestine
Elevated Receptors -> Expression Targets in Mouth
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
GH1/GHR -> STAT Expression Targets
GH1/PRLR Expression Targets
TAM Receptor Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
Asbestosis- and Silicosis-Associated Inflammation Provokes Cancer Development
Proteins with Altered Expression in Tumor-Promoting Inflammation
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
VEGFA Dependent Angiogenesis in Cancer
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
IDO1 in Cancer Immune Escape
Fibronectin Expression Targets
Fibrinogen Expression Targets
NOTCH -> Expression Targets in Skin
IFNG/IFNR Expression Targets
IL1R -> STAT3 Signaling
IL1R -> NF-kB Signaling
IL13 Expression Targets
IL16 -> AP-1 Expression Targets
IL3 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
IL16 -> NF-kB Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
S1P Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Cell Adhesion Receptors -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Bone Marrow
C5AR1 -> Expression Targets in Lymphoid System and Blood
IgE Receptors -> Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Thymus
CNR1-> Expression Targets in Nerve Tissue
GPCRs -> Expression Targets in Brain
P2RX7 -> Expression Targets in Nerve Tissue
Elevated Receptors -> Expression Targets in Nerve Tissue
BDNF Expression Targets
OSM/OSMR Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
NTS Expression Targets
POMC Expression Targets
IFNA1/Gq Expression Targets
TAC1 Expression Targets
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
CSF1 -> STAT Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
PAF Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
MSTN/ACVR2/BMPR Expression Targets
Elevated Receptors -> Expression Targets in Lung
TCR -> AP-1 Expression Targets
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
Dioxin Induced Chloracne (Hypothesis)
WNT5A Expression Targets
e
pathway 4
New Pathway (2)
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of systolic blood pressure
Neighbors of blood glucose
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of monocyte count
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of functional recovery
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of bone mass
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of glucose tolerance
Neighbors of morbidity
Neighbors of fibrosis progression
Neighbors of mortality rate
Neighbors of fat mass
Neighbors of exhaustion
Neighbors of bone mineral density
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of cell density
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular reactivity
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of systolic blood pressure
Neighbors of blood glucose
Neighbors of renal hypertrophy
Neighbors of fasting plasma glucose
Neighbors of osteoclast number
Neighbors of cancer recurrence
Neighbors of energy expenditure
Neighbors of glucose level
Neighbors of vascular tone
Neighbors of left ventricular ejection fraction
Neighbors of breast cancer risk
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of functional status
Neighbors of gastric cancer risk
Neighbors of neurological outcome
Neighbors of infarct area
Neighbors of fertility
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of monocyte count
Neighbors of metabolic response
Neighbors of insulin level
Neighbors of comorbidity
Neighbors of bone volume
Neighbors of fibroblast phenotype
Neighbors of fractional shortening
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of macrophage function
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of neointima
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of respiratory hypersensitivity
Neighbors of myocardial fibrosis
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of aortic smooth muscle cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of bone marrow derived mast cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of luteal cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of cardiovascular system
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of lymphatic system
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of allantois
Neighbors of coronary artery
Neighbors of left ventricle
Neighbors of uterine cervix
Neighbors of vein
Neighbors of arteriole
Neighbors of villus
Neighbors of nose
Neighbors of eye
Neighbors of cornea
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of lymph node of mesentery
Neighbors of mammary gland
Neighbors of vagina
Neighbors of ankle joint
Neighbors of vitreous body
Neighbors of thymus gland
Neighbors of cerebral cortex
Neighbors of brain blood vessel
Neighbors of myelin sheath
Neighbors of bladder
Neighbors of nervous system
Neighbors of blastocyst
Neighbors of nasopharynx
Neighbors of periodontal ligament
Neighbors of corpus luteum of ovary
Neighbors of sympathetic nervous system
Neighbors of nerve
Neighbors of endocrine system
Neighbors of globus pallidus
Neighbors of lymphatic vessels
Neighbors of pleura
Neighbors of Fallopian tube
Neighbors of hypothalamus
Neighbors of choroid plexus
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of Ang II receptor
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of histone H3
Neighbors of alpha2 adrenoceptor
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of immunoglobulin
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of ITG
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of relaxin
Neighbors of TLR1/2 heterodimer
Neighbors of TORC1
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of adrenoceptor
Neighbors of phosphodiesterase
Neighbors of caspase
Neighbors of deacetylase
Neighbors of TLR4/Myd88
Neighbors of TNF-alpha receptor
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
sars-cov no binding
dsRNA induces innate immunity and INFs in alveolar cells
Dendritic Cell Activation in COVID19
Figure 2_Levothyroxine and aspirin effects crossing
Figure 2_Levothyroxine and aspirin effects crossing
Overview. Diseases of the digestive system (chapter 10)
1_Inflammation in keratinocytes in the pathology of acne
1_Differentiation of psoriatic T cells
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
2_Lipotoxicity in NAFLD
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
3_Impairment of iron release from splenic macrophages
5_The rationale for the treatment of anemia of chronic disease with erythropoietin
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
drug-target pairs direct regulation
drug-target moltransport
drug-target molsynthesis
Differentiation of psoriatic T cells

Group Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Graves Ophthalmopathy
Genes with Polymorphisms Associated with Migraine
Genes with Mutations Associated with Multiple Sclerosis
other partners for SARS

MedScan ID 3553

LocusLink ID 3553
16176
24494

Alias pro-interleukin-1-beta
OTTHUMP00000203695
OTTHUMP00000203694
IL1B
interleukin 1B
OTTHUMP00000203693
preinterleukin 1 beta
Interleukin IL1 beta
IL1B_HUMAN
RP23-384K11.2
beta interferon inducing 22 k factor
Catabolin
IL1F2
interleukin IL1B
OTTMUSP00000016525
interleukin IL1F2
IL1beta
interleukin 1 beta
interferon beta inducing 22k factor
interleukin IL1B_HUMAN
IL-1
IL1-BETA
IL-1 beta
interleukin-1 beta
Il-1b
IL-1beta
IL-1F2
interleukin 1, beta

GO ID 0005125
0005178
0005149
0019904
0000165
0000187
0006915
0048143
0007267
0035690
0071222
0071260
0071407
0071310
0019221
0035234
0007566
0097192
0001660
0030213
0006955
0006954
0032611
0070498
0032635
0031663
0070487
0043407
0070164
0008285
2001240
0010829
0046627
0050995
0045833
0050768
0050805
0030593
0051091
0043123
0046330
0051092
1901224
1902680
0002711
0042102
2000556
0045766
0060559
0060355
0051781
0030335
0008284
0045080
0045917
0010718
0031622
0010628
0060252
0032725
0034116
0035066
0033129
0050729
0032729
0045086
0045410
0032755
2000778
0032757
0050996
0051044
0045840
0071639
0035505
0150078
0045429
1900745
0050766
0031394
0032308
0046827
0001934
0045944
0045893
0010575
0030949
0043491
0070372
0043122
0050691
1903140
0050796
0050767
0050999
0033198
0009743
0070555
0032496
0030730
0007165
0014805
0005829
0070062
0005576
0005615
0005764
0030141
0050900
0007613
2000173
0010629
0014050
2000178
0045665
0000122
0070374
0043507
0043065
0048711
0010942
0007204
0045687
0033092
0043525
0090023
0032874
0035176
0005737
0031410
0031982
0002526
0071236
0071398
0071333
0071396
0002439
0007611
0030728
0010469
0033591
0071548
0042493
0032355
0045471
0010332
0051384
0009408
0001666
0035902
0043278
0007584
0014070
0010243
0010193
0043434
0035634
0033280
0042060
0005776
0002437
2000866
0005622
0005623
0071414
0043066
0008210
0005102
0019742
0001525
0030638
0006144
0007568
0010977
0006916
0009100
0036273
0036270
0042221
0042346
0010552
0008083

KEGG ID hsa:3553
mmu:16176
rno:24494

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 2 62.97 cM
2 73.0 cM

OMIM ID 147720
137215

Rat chromosome position 3q36

Hugo ID 5992
HGNC:5992

Human chromosome position 2q14.1
2q14

Swiss-Prot Accession P01584
P01584.2
P10749
P10749.1
Q5BKB0
Q63264.1
Q53X59
Q53XX2
Q7M4S7
Q7RU01
Q96HE5
Q9UCT6
Q2M4J6
O43645
Q63264
Q3TI17

PIR ID A21851
A25542
I55969

GenBank ID NC_000002
NM_000576
NP_000567
XM_017003988
XP_016859477
NG_008851
AC079753
AAX88888
AY137079
AAM88883
BN000002
CAD29872
CH471217
EAW73605
EAW73606
EAW73607
JA104597
CCA63968
LC333978
M15840
AAA74137
X04500
CAA28185
X52430
X52431
AB451494
BAG70308
AF043335
AAC03536
AK313983
BC008678
AAH08678
BT007213
AAP35877
CR407679
CAG28607
K02770
AAA36106
M15330
AAA59135
M54933
AAA59136
X02532
CAA26372
X56087
CAA39567
P01584
NC_000068
XM_006498795
XP_006498858
NM_008361
NP_032387
AL808143
AY902319
AAX90604
CH466519
EDL28238
U03987
X04964
CAA28637
AK156396
AK157245
AK168047
BAE40029
AK224980
AK225002
AK225003
BC011437
AAH11437
M15131
AAA39276
P10749
NC_005102
NM_031512
NP_113700
AC_000071
AABR07053713
AAHX01025010
CH473949
EDL80163
BC091141
AAH91141
M98820
AAA41426
Q63264
NT_039207
AAHY01020661
XP_006712559
ABM84780
NW_047658
AC_000045
DQ893854
NW_001084813
Q2M4J6
Q3TI17
Q5BKB0
NT_022135
AMYH02004594
NW_001030694
AC_000024
AABR06026121
AABR06026120
ABM81599
O43645
CAM22719
AC_000134
DQ890673
NW_001838841
NC_018913
ABBA01074249
NW_921474
XM_006712496

Swiss-Prot ID IL1B_HUMAN
IL1B_MOUSE
Q5BKB0_RAT
Q2M4J6_MOUSE

Cell Localization Cytoplasm
Cytosol
Lysosome
Secreted
Exosome
Cytoplasmic vesicle
Autophagosome
Cytoplasm, cytosol
Secreted, exosome
Cytoplasmic vesicle, autophagosome
Extracellular

Ensembl ID ENSG00000125538
ENSP00000263341.2
ENST00000263341.6
ENSMUSG00000027398
ENSMUSP00000028881.7
ENSMUST00000028881.13
ENSRNOG00000004649
ENSRNOP00000006308.2
ENSRNOT00000006308.4
ENSMUST00000028881
ENSRNOT00000006308
ENSP00000263341
ENST00000263341
ENSRNOP00000006308
ENSMUSP00000028881

MGI ID MGI:96543
96543

RGD ID 2891

TCDB ID 1.A.109.1.2

Unigene ID Rn.9869
Hs.126256
Mm.222830

Homologene ID 481

Shape Rhomb

IPI ID IPI00114067
IPI00876594
IPI00307223
IPI00206984