Protein JAK1

URN urn:agi-llid:3716
Total Entities 0
Connectivity 11657
Name JAK1
Description Janus kinase 1
Notes This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway I-cell: CCK-8 Secretion and Regulation of Eating Behavior
T-Cell Dependent B-Cell Activation
V(D)J Recombination Activation
Immunoglobulin Class-Switch Recombination Activation
Immunoglobulin Genes Transcriptional Activation
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
CD8+ T-Cell Activation
T-Cell Cytotoxic Mediated Cell Death
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
AHR Signaling in Treg and Dendritic Cells Function
AHR Signaling in Th17 Cells Function
Th17-Cell Differentiation
AHR Signaling in Tr1 Cells Function
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Proplatelet Maturation
AHR in Intestinal Cell Antimicrobial Barrier Maintenance
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation without Degranulation through CXCR4 Signaling
Mast-Cell Activation without Degranulation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
anti-Inflammatory Function of Macrophage M2 Lineage
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Adipokines Production by Adipocyte
Nociception Expression Targets Signaling
CCR1 Expression Targets
IL6 Expression Targets -> Nociception
Proteins Involved in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Preconditioning Ischemia
Lymphocyte Mediated Myocardial Injury in Myocarditis
SOCS in Negative Feedback Regulation in Myocarditis
Hair Follicle Keratinocyte Apoptosis
Acute Phase in Atopic Dermatitis
Atopic Dermatitis
Melanoma
Apoptosis Block in Melanoma Cell
T-Cells Differentiation Block in Psoriasis
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Oxidative Stress in Vitiligo
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Proliferative Diabetic Retinopathy
Adipokines and Cytokines in Insulin Resistance in Skeletal Muscles
Proteins Involved in Insulin Resistance
Adiponectin Synthesis Declines in Insulin Resistance
Insulin Resistance in Hepatocytes
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Hashimoto's Thyroiditis
Thyroid Hormones in Adipose Tissue Metabolism
Thyroid Dysfunction
Graves Ophthalmopathy
Immune System Activation in Hyperthyroidism
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyrotropin Releasing Hormone (TRH) Hypothalamic Release in non-Autoimmune Hypothyroidism
Central Hypothyroidism
Tertiary Hypothyroidism
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Metastatic Colorectal Cancer
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Apoptosis Block in Acute Myeloid Leukemia Cell
RARA Signaling in Acute Myeloid Leukemia (M3)
Acute Myeloid Leukemia
B-Cell Acute Lymphoblastic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Hodgkin and Reed-Sternberg Cells Reprogramming
Mantle Cell Lymphoma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
TRPM7/8 in Pancreatic Adenocarcinoma
Eosinophil Survival in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
Periostin (POSTN) Production by Airway Epithelium in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
Goblet-Cell Exocytosis in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
B-Cell Mediated IgE Production in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
CCR5 Signaling in Macrophages
Th17-Cell Numbers Reduction in HIV
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Diabetes Induced Periodontitis
Cowden Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Bone Loss in Osteoporosis
BDNF Upregulation Triggered by Seizures
Glioma Invasion Signaling
Glioma Stem Cell Program Activation
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
IL6/JAK/STAT3 Signaling in Cholesteatoma
Cholesteatoma
Prostate Cancer
IL10/STAT3 Signaling in M2 Macrophage and Retinal Angiogenesis
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Cytokines Trigger Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Endothelial Cell Dysfunction in Pyelonephritis
IFNG -> ARRB1/STAT1 Signaling
CLCF1 Expression Targets
CTF1 Expression Targets
CXCL12 Expression Targets
CCL3 Expression Targets
CCL3L1 Expression Target
CCL16 Expression Targets
CCL5 Expression Targets
CCL7 Expression Target
CCL7 Expression Targets
CCL8 Expression Targets
CCL2 Expression Targets
CSF3 Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
CNTF Expression Targets
Clozapine Induced Granulocytopenia
GH2/GHR Expression Target
GH1/GHR -> STAT Expression Targets
CSH1/GHR Expression Targets
Receptors and Adaptor Proteins Activated in Cancer
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
IL13/STAT6/ZEB1 Signalling Promotes Cancer Metastatic Progression
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
VEGFA Dependent Angiogenesis in Cancer
Epithelial to Mesenchymal Transition in Cancer: Overview
Cancer Cells Inhibit Adipocyte Differentiation
Skeletal Muscle Wasting in Cancer Cachexia
Treg Cells Promote Immunosuppression in Cancer Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IDO1 in Cancer Immune Escape
IGF2 -> STAT Expression Targets
IGF1 -> STAT Expression Targets
Insulin -> STAT Expression Targets
IGF1R -> STAT Signaling
IFNLR1-> STAT/NFKB Signaling
IFNW1/IFNR Expression Target
IFNA1/IFNR Expression Targets
IFNB1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL22R -> STAT3 Signaling
IL13R -> STAT6 Signaling
IL31R -> STAT Signaling
IL15R -> STAT Signaling
IL7R -> FOXO/NF-kB Signaling
IL15R -> NF-kB/NFATC Signaling
IL2R -> ELK/SRF/MYC Signaling
IL10R -> STAT Signaling
IL13R -> STAT Signaling
IL3R -> STAT Signaling
IL27R -> STAT Signaling
IL7R -> STAT Signaling
IL9R -> STAT Signaling
IL5R -> STAT Signaling
IL11R -> STAT3 Signaling
IL6R -> STAT Signaling
IL2R -> STAT Signaling
IL6ST -> STAT5B Signaling
IL4R -> STAT Signaling
IL23R -> STAT3/NF-kB Signaling
IL21R -> STAT Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL7 Expression Targets
IL13 Expression Targets
IL21 Expression Targets
IL15 Expression Targets
IL3 Expression Targets
IL6 Expression Targets
IL10 Expression Targets
IL5 Expression Targets
IL22 Expression Targets
IL11 Expression Targets
IL9 Expression Targets
IL31 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
UrokinaseR -> STAT Signaling
PTPRC -> STAT6 Expression Targets
OSM/OSMR Expression Targets
OSM/IL6ST/LIFR Expression Targets
PRL/GHR -> STAT Expression Targets
PTPRC -> STAT6 Signaling
FOXO1 Signaling
Ras-GAP Regulation Signaling
LTA Expression Targets
TNF -> STAT Expression Targets
TNFRSF1A -> STAT Signaling
B-Cell Differentiation Inhibition by Dioxin
PLAU -> STAT1 Expression Targets
PLAU -> ELK-SRF/AP-1 Expression Targets
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
Model of PPARG signaling in psoriasis
New Pathway (3)
dsRNA induces innate immunity and INFs in alveolar cells
IFN signaling in alveolar cells
Dendritic Cell Activation in COVID19
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
2_The role of endothelial cells in pyelonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Cardiomyocyte hypertrophy
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
2_CD8+ T-cell response and mucosal damage in celiac disease
5_Tax-mediated dysregulation of NF-kB signaling in HTLV-1 infection
1_Inflammatory mediators increase the production of hepcidin (HAMP)
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Defective tolerance of autoreactive T-cell in T1D
1_Decreased secretion of thyroid hormones
Differentiation of psoriatic T cells
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes with Mutations Associated with B-Cell Acute Lymphoblastic Leukemia
Proteins Involved in B-Cell Acute Lymphoblastic Leukemia
Genes with Mutations Associated with T-Cell Acute Lymphoblastic Leukemia
Proteins Involved in Cowden Syndrome

MedScan ID 3716

LocusLink ID 3716
16451
84598
230508
100022
319959
362552

Alias OTTMUSP00000008566
BAP004
Janus protein tyrosine kinase 1
Janus kinase I
JAK1B
Tyrosine-protein kinase JAK1
MGC37919
JAK1A
LOC105378775
AA960307
kinase JAK1
Janus kinase 1
Jak I
C130039L05
Tyrosine-protein kinase JAK I
C130039L05Rik
Janus kinase 1 (a protein tyrosine kinase)
JAK1
JTK3
LOC362552
RP23-336G7.2
Janus protein tyrosine kinase I
JAK1 kinase
kinase JAK I
RIKEN cDNA C130039L05 gene
OTTHUMP00000010896
JAK-1
expressed sequence AA960307

EC Number 2.7.10.2
2.7.10.1
2.7.1.112

GO ID 0005524
0031730
0005131
0046872
0004715
0019903
0004713
0031625
0000165
0019221
0060333
0035722
0035723
0038110
0038114
0070106
0070757
0070102
0038111
0038113
0035556
0018108
1903672
0006468
0060334
0046677
0060337
0005737
0005856
0005829
0005768
0005925
0016020
0005634
0016301
0000166
0004672
0016740
0036016
0098761
0007167
0016310
1904894
0007260
0005088
0005622
0045087
0031234
0016477
0043547
0007243
0007169
0046777
0005102
0005515
0016772
0038083
0012505
0030154
0060338
0042127
0004718
0023034
0016021
0004872
0007242

KEGG ID hsa:3716
rno:84598
mmu:16451

MedLine Reference 10967130
12087100
12477932
12487370
12584205
15126250
16413512
10200816
10349636
10374907
10526570
10781830
10872802
10922068
11042159
11058581
11076861
11114734
11217851
11390995
11437454
12466851
12576323
12738762
15254900
15456882
15659653
15782199
1581631
15923602
15988755
16141072
16141073
16280321
16417589
16737695
17114464
1848670
2466296
2482828
7490523
7539296
7542761
7544789
7579387
7589562
7613027
7713924
7796811
7929391
8331382
8514334
8535092
8593242
8608597
8662243
8889548
8918879
8934548
9229117
9342212
9360952
9524251
9548458
9553136
9590172
9638363
9889194
10433356
10502458
10531356
10586060
10702271
10825200
10875931
10899310
10982844
10993906
11016959
11133764
11162588
11163768
11201744
11418623
11468294
11527382
11557047
11722592
11742534
11786531
11801527
12130510
1213395
12133952
12200137
12223098
12374810
12551917
12559972
12620806
12777975
12960323
1373877
15883164
15894543
16102578
16239216
16767694
7499365
7512720
7698020
7973659
8232552
8272872
8536716
8700888
8702790
8756628
8995399
9020188
9178903
9417082
9446616
9452495
9492017
9516124
9566874
9774657
15194700
17158029
17433443
8247543
8022486
11244571

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 4 46.19 cM
4 46.3 cM

OMIM ID 147795

Rat chromosome position 5q33
5q31.3-q35

Hugo ID 6190
HGNC:6190

Human chromosome position 1p31.3
1p32.3-p31.3

Swiss-Prot Accession P23458
Q6P669
P23458.2
B1ASP2
Q3U8P8
Q3URU8
P52332.1
G3V9W2
Q59GQ2
Q9UD26
P52332
Q0VGA4
Q4LDX3
Q8IV82
Q3TI10
Q3UZ30
Q8CFX4
Q8K0I7
O35803
Q5FVF5
Q8CIZ4
JAK1_HUMAN
B1ASP2_MOUSE
Q3U8P8_MOUSE
Q6ZRA6

PIR ID A39577

GenBank ID NC_000001
NM_001321856
NP_001308785
NM_001320923
NP_001307852
NM_001321852
NP_001308781
NM_001321854
NP_001308783
NM_001321853
NP_001308782
NM_001321857
NP_001308786
NM_002227
NP_002218
NM_001321855
NP_001308784
NG_023402
AC093427
AL357078
AL590436
AL606517
CH471059
EAX06547
EAX06548
HC002094
CBG22571
KC876867
KC876881
KF495968
KT584867
AB209057
BAD92294
AB219242
BAE02826
AK128375
AK314257
BC009079
BC023604
AAH23604
BC062431
AAH62431
BC111401
AAI11402
BC132729
AAI32730
BX647675
BX648044
HQ628631
AER93381
M64174
AAA36527
P23458
NC_000070
NM_146145
NP_666257
XM_006502812
XP_006502875
XM_011240451
XP_011238753
NM_013567
AL627251
AL645668
CH466527
EDL30874
AK029232
AK033004
AK081552
AK133866
AK134143
BAE22031
AK141210
BAE24589
AK143650
AK148521
AK152128
BAE30969
AK161759
AK168058
BAE40036
AK180982
AK181063
AK181487
AK183753
AK196334
AK208150
BC024100
BC031297
AAH31297
BC039752
AAH39752
BC058993
M33425
AAA40016
S63728
AAB27517
P52332
NC_005104
XM_006238452
XP_006238514
XM_006238453
XP_006238515
NM_053466
NP_445918
AC_000073
AABR07049385
AAHX01038760
CH473998
EDL97824
AF540911
AAN59910
AJ000556
CAA04187
BC090029
AAH90029
FQ227839
FQ231507
FQ233794
XM_006502813
CAM21388
CAM21389
XP_005270898
AMYH02001172
AMYH02001173
AABR06038934
XP_011540812
AABR06038935
XM_011549220
XP_011539697
AC_000026
ABBA01074552
ABBA01074553
ABBA01074554
XP_006502876
XP_006710687
XM_005270841
XP_011547522
AC_000133
NC_018912
XM_011542510
XM_006710624
XM_011541395
AAHY01038557
AAHY01038558
NT_032977
NW_001838579
NW_921351
AC_000044
Q0VGA4
Q4LDX3
Q6P669
Q8IV82
NT_039264
NW_001030747
Q3TI10
Q3U8P8
Q3URU8
Q3UZ30
Q8CFX4
Q8K0I7
NW_047717
NW_001084842
O35803
Q5FVF5
Q8CIZ4
Q9UD26
XM_342872
XP_342873
XM_001061647
XP_001061647
BAC87406
Q59GQ2
Q6ZRA6
BG067874
BG074678
BF224937
BG080932
BG087301
NW_000211
BQ032637
2288925
24415844
58476629
81866487
81886638
81909629
123783325
123788792
123794305
123795003
1708580
200576
21410529
27370733
74137337
74189929
74207575
74212448
81878055
81878341
8248854
AA960307
111494091
119626952
121946632
121948500
124375862
125060
190735
27469796
34535713
38382952
62087694
68299593
74711103
74720332
74728049
74737464
74741308
119626953
123254037
148698927
149044565

Swiss-Prot ID JAK1_HUMAN
B1ASP2_MOUSE
Q3URU8_MOUSE
Q3U8P8_MOUSE

Cell Localization Endomembrane system
Cytoplasm

Ensembl ID ENSG00000162434
ENSP00000343204.4
ENST00000342505.5
ENSMUSG00000028530
ENSMUSP00000099842.3
ENSMUST00000102781.9
ENSRNOG00000011157
ENSRNOP00000061649.1
ENSRNOT00000064542.1
ENST00000342505.4
ENSMUSP00000099842
ENSMUST00000102781
ENSRNOT00000064542
ENST00000342505
ENSRNOP00000061649
ENSP00000343204

MGI ID MGI:96628
96628
2140180
2443062

RGD ID 69056

Unigene ID Hs.207538
Mm.289657
Rn.90191
Mm.185636

Homologene ID 1678

Shape Sickle-vertex

IPI ID IPI00784013
IPI00775993
IPI00126078
IPI00649788
IPI00212981

Homo sapiens Chromosome position 1p32.3-p31.3

Ensembl Transcript ID ENST00000342505

FunctionalClass protein binding
protein-tyrosine kinase
ATP binding
Janus kinase
kinase
nucleotide binding
protein kinase
transferase
growth hormone receptor binding
receptor

Mus musculus Chromosome position 4 46.3 cM
4

KEGG pathway Adipocytokine signaling pathway
Jak-STAT signaling pathway

Rattus norvegicus Chromosome position 5q31.3-q35
5q33

Ensembl Gene ID ENSG00000162434