URN | urn:agi-llid:4903 |
---|---|
Total Entities | 0 |
Connectivity | 3387 |
Name | PTPN11 |
Description | protein tyrosine phosphatase, non-receptor type 11 |
Notes | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016] |
Primary Cell Localization | Cytoplasm |
Class | Protein phosphatase |
Pathway | Leptin and CCK8 Activate Nodose Ganglia Neuron |
---|---|
Natural Killer Cell Inhibitory Receptor Signaling | |
Peripheral T-Cell Tolerance | |
Do not Eat me\xc2\x9d Signal: Viable Cells Inhibits Phagocytosis | |
Eosinophil Survival by Cytokine Signaling | |
Mast-Cell Activation via IgE Signaling | |
Mast-Cell Activation without Degranulation | |
Mast-Cell Activation without Degranulation through KIT/F2R Signaling | |
Negative Acute Phase Proteins Synthesis | |
Positive Acute Phase Proteins Synthesis | |
IL6 Expression Targets -> Nociception | |
Proteins Involved in Atherosclerosis | |
Proteins Involved in Dilated Cardiomyopathy | |
IL22 Induces Keratinocyte Proliferation in Psoriasis | |
Insulin Resistance in Hepatocytes | |
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease | |
Immune System Activation in Hyperthyroidism | |
Proteins Involved in Helicobacter Infections | |
CagA Phosphorylation Dependent Signaling | |
Proteins Involved in Acute Myeloid Leukemia | |
IL6/IGF1/VEGFA Signaling in Multiple Myeloma | |
Multiple Myeloma | |
Mast-Cell Activation in Asthma | |
Mast-Cell Related Chemokines Signaling in Asthma | |
IL6 Promotes Inflammation in Muscular Dystrophies | |
Leptin Role in Endometriosis | |
Noreadrenaline/Gq Expression Targets | |
Epinephrine/Gq Expression Targets | |
SELE -> ELK-SRF Signaling | |
Erythropoietin -> ELK/SRF Expression Targets | |
PECAM1 Expression Targets | |
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets | |
CSH1/GHR Expression Targets | |
Receptors and Adaptor Proteins Activated in Cancer | |
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling | |
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling | |
Effector T-cell Inactivation in Cancer Immune Escape | |
PECAM -> SP1 Signaling | |
IL6R -> CEBP/ELK/SRF Signaling | |
IL6 Expression Targets | |
Leptin -> ELK/SRF Expression Targets | |
LPA Expression Targets | |
AGT -> TP53 Expression Targets | |
AGT -> CREB Expression Targets | |
AGT -> ELK/SRF Expression Targets | |
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets | |
AXL Receptor Tyrosine Kinase Signaling | |
ROS and RNS in Vasoconstriction and Vasodilation Regulation | |
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy | |
sialic | |
2_Interleukin-17 and interleukin-22 signaling in psoriasis | |
2_Defective tolerance of autoreactive T-cell in T1D | |
Interleukin-17 and interleukin-22 signaling in psoriasis |
Group | Genes with Mutations Associated with Acute Myeloid Leukemia |
---|---|
Genes Associated with Syndromic Epilepsy |
MedScan ID | 4903 |
---|
LocusLink ID | 4903 |
---|---|
5781 | |
19247 | |
25622 |
Alias | Src homology phosphatase-2 |
---|---|
phosphotyrosine phosphatase 1D | |
protein tyrosine phosphatase SH-PTP2 | |
RIKEN cDNA 2700084A17 gene | |
protein tyrosine phosphatase-2 | |
protein tyrosine phosphatase, nonreceptor type 11 isoform II | |
Src homology region phosphatase SHP2 | |
Src homology phosphatase SHP2 | |
protein tyrosine phosphatase, non receptor type 11 | |
PTNB_HUMAN | |
phosphatase SHP2 | |
Noonan syndrome 1 gene | |
Src homology region 2 domain-containing phosphatase 2 | |
OTTMUSP00000017430 | |
Src homology region 2 domain-containing protein tyrosine phosphatase SHP-2 | |
protein-tyrosine phosphatase SYP | |
SH2 domain-containing protein tyrosine phosphatase-2 | |
protein tyrosine phosphatase, nonreceptor type 11 (Noonan syndrome 1) | |
protein tyrosine phosphatase, non receptor type 11 (Noonan syndrome 1) | |
SH2 domain-containing protein tyrosine phosphatase II | |
Noonan syndrome 1 protein | |
SH-PTP2 | |
BPTP3 | |
SHP2 | |
protein tyrosine phosphatase, nonreceptor type 11 isoform 1 | |
Src homology region phosphotyrosyl phosphatase SHP2 | |
nonreceptor protein tyrosine phosphatase 11 | |
protein tyrosine phosphatase, non receptor type 11 isoform 1 | |
Src homology region domain 2 containing protein phosphatase 2 | |
protein tyrosine phosphatase, non receptor type 11 isoform 2 | |
non receptor protein tyrosine phosphatase 11 | |
NS I | |
protein tyrosine phosphatase SHP2 | |
PTP1D | |
tyrosine phosphatase 2C | |
SHPTP2 | |
SHP2/pp75 | |
MGC14433 | |
protein tyrosine phosphatase, nonreceptor type 11 isoform I | |
Src homology phosphotyrosyl phosphatase SHP2 | |
Src homology 2 domain protein tyrosine phosphatase SHP-2 | |
SH-PTP3 | |
protein tyrosine phosphatase, non receptor type 11 isoform II | |
Src homology 2 domain-containing protein tyrosine phosphatase SHP-2 | |
METCDS | |
SHP2 phosphatase | |
SH-PTP2 protein tyrosine phosphatase nonreceptor type 11 | |
2700084A17 | |
Noonan syndrome I gene | |
protein tyrosine phosphatase, nonreceptor type 11 isoform 2 | |
protein-tyrosine phosphatase 1D | |
AW536184 | |
Src homology region phosphatase-2 | |
PTP2C | |
PRO1847 | |
Src homology domain 2 containing protein phosphatase 2 | |
SH2 domain-containing protein tyrosine phosphatase SHP-2 | |
PTNB | |
PTPN11 | |
2700084A17Rik | |
OTTHUMP00000166108 | |
Noonan syndrome I protein | |
protein-tyrosine-phosphatase, nonreceptor type 11 | |
Src homology region 2 domain protein tyrosine phosphatase SHP-2 | |
protein tyrosine phosphatase, non receptor type 11 isoform I | |
SH-PTP2 protein tyrosine phosphatase non receptor type 11 | |
CFC | |
NS1 | |
JMML | |
PTP-1D | |
PTP-2C | |
protein-tyrosine phosphatase 2C | |
tyrosine-protein phosphatase non-receptor type 11 | |
Syp | |
SAP-2 | |
SHP-2 | |
SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 | |
encodes catalytic domain | |
SH-PTP2 protein tyrosine phosphatase non-receptor type 11 | |
null | |
protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | |
protein tyrosine phosphatase, non-receptor type 11 isoform I | |
protein tyrosine phosphatase, non-receptor type 11 isoform 2 | |
protein tyrosine phosphatase, non-receptor type 11 | |
protein tyrosine phosphatase, non-receptor type 11 isoform 1 | |
protein tyrosine phosphatase, non-receptor type 11 isoform II |
EC Number | 3.1.3.48 |
---|
GO ID | 0031748 |
---|---|
0005070 | |
0050839 | |
0005158 | |
0043560 | |
0004726 | |
0051428 | |
0043274 | |
0004721 | |
0001784 | |
0019904 | |
0019901 | |
0004725 | |
0030971 | |
0060020 | |
0000077 | |
0038127 | |
0031295 | |
0033277 | |
0000187 | |
0036302 | |
0007411 | |
0007420 | |
0071345 | |
0071364 | |
0071260 | |
0021697 | |
0019221 | |
0048013 | |
0007173 | |
0060325 | |
0008543 | |
0048806 | |
0042593 | |
0007507 | |
0048873 | |
0042445 | |
0009755 | |
0048839 | |
0007229 | |
0070102 | |
0061582 | |
0050900 | |
0035855 | |
0032528 | |
0035264 | |
0048609 | |
0033629 | |
0051463 | |
0060125 | |
0046676 | |
0048011 | |
0035265 | |
0035335 | |
0030168 | |
0030220 | |
0048008 | |
0070374 | |
0046326 | |
0046887 | |
0046628 | |
0032728 | |
0032755 | |
0045931 | |
0050731 | |
0051897 | |
0032760 | |
0033628 | |
0043254 | |
0046825 | |
0060338 | |
0006641 | |
0005737 | |
0005829 | |
0005739 | |
0005654 | |
0005634 | |
0032991 | |
0016787 | |
0016791 | |
1990782 | |
0007409 | |
0016311 | |
0006629 | |
0046888 | |
0009967 | |
0006470 | |
0030054 | |
0016020 | |
0001725 | |
0040014 | |
0016303 | |
0046934 | |
0046854 | |
0036092 | |
0048015 | |
2001275 | |
0014066 | |
0043234 | |
0038095 | |
0007596 | |
0045087 | |
0008286 | |
0060333 | |
0060334 | |
0060337 |
KEGG ID | hsa:5781 |
---|---|
mmu:19247 | |
rno:25622 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus |
Mouse chromosome position | 5 |
---|
OMIM ID | 176876 |
---|---|
607785 | |
151100 | |
156250 | |
163950 |
Rat chromosome position | 12q16 |
---|
Hugo ID | 9644 |
---|---|
HGNC:9644 |
Human chromosome position | 12q24.13 |
---|---|
12q24 |
Swiss-Prot Accession | Q06124 |
---|---|
Q06124.2 | |
P35235 | |
P35235.2 | |
P41499 | |
P41499.4 | |
A8K1D9 | |
Q96HD7 | |
Q3TQ84 | |
Q64509 | |
Q6PCL5 | |
Q62626 |
PIR ID | JN0805 |
---|---|
A46209 | |
A53593 |
Swiss-Prot ID | PTN11_HUMAN |
---|---|
PTN11_MOUSE | |
PTN11_RAT |
Cell Localization | Cytoplasm |
---|---|
Nucleus |
Ensembl ID | ENSG00000179295 |
---|---|
ENSP00000489597.1 | |
ENST00000635625.1 | |
ENSP00000340944.2 | |
ENST00000351677.6 | |
ENSP00000376376.1 | |
ENST00000392597.5 | |
ENSMUSG00000043733 | |
ENSMUSP00000098333.2 | |
ENSMUST00000100770.8 | |
ENSMUSP00000058757.7 | |
ENSMUST00000054547.8 | |
ENSRNOG00000030124 | |
ENSRNOP00000041842.5 | |
ENSRNOT00000046323.5 | |
ENSP00000340944 | |
ENST00000351677 | |
ENSP00000376376 | |
ENST00000392597 | |
ENSP00000489597 | |
ENST00000635625 | |
ENSMUSP00000098333 | |
ENSMUST00000100770 | |
ENSMUSP00000058757 | |
ENSMUST00000054547 | |
ENSRNOP00000041842 | |
ENSRNOT00000046323 |
MGI ID | MGI:99511 |
---|
RGD ID | 3447 |
---|
Unigene ID | Hs.506852 |
---|---|
Mm.8681 | |
Rn.98209 |
Homologene ID | 2122 |
---|
Shape | 2Triangles |
---|