Protein IL23A

URN urn:agi-llid:51561
Total Entities 0
Connectivity 767
Name IL23A
Description interleukin 23 subunit alpha
Notes This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand

Pathway Th17-Cell Differentiation
Macrophage M1 Lineage
Lymphocyte Mediated Myocardial Injury in Myocarditis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
Th17-Cell Function in Systemic Lupus Erythematosus
Th17-Cell Activation in Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Th17-Cell Differentiation in Asthma
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Th17-Cell Numbers Reduction in HIV
CD4+ T-Cell Function Decline in HIV
Genes with Mutations Associated with Psoriatic Arthritis
Proteins with Altered Expression in Psoriatic Arthritis
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
Immune System Role in Otitis Media
Elevated Receptors -> Expression Targets in Colon
IL23A and IL17A Provoke Cancer-Associated Inflammation
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
Proteins with Altered Expression in Tumor-Promoting Inflammation
IL23R -> STAT3/NF-kB Signaling
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Bone Marrow
C5AR1 -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Breast
PPAR Psoriasis
1_Differentiation of psoriatic T cells
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Psoriasis
Genes with Mutations Associated with Psoriatic Arthritis

MedScan ID 51561

LocusLink ID 51561
83430
155140

Alias interleukin IL23P19
MGC79388
SGRF
interleukin 23 p19 subunit
interleukin 23p19
JKA3 induced upon T-cell activation
interleukin 23, alpha subunit p
UNQ2498/PRO5798
MGC114275
interleukin-six, G-CSF related factor
interleukin 23 alpha subunit
interleukin 23 alpha
interleukin 23, alpha subunit p19
IL23A
interleukin-23 subunit alpha
IL23P19
IL-23 subunit alpha
interleukin IL23A
interleukin 23A
interleukin-23 subunit p19
P19
IL-23
IL-23A
IL-23-A
IL-23p19

GO ID 0005125
0045519
0042098
0019221
0050829
0051607
0006954
0045087
0038155
0032693
1901224
0051135
0051142
0001916
0042102
0002827
2000330
2000318
0042104
0010536
0002230
0032725
0050729
0032729
0032733
0032735
0032740
0043382
0032816
0032819
0090023
0045672
0034105
0045944
0032760
0042531
0042509
0048771
0005788
0005576
0070743
0006955
0002376
0005615
0010469
0042346
0010535
0042517
0042520
0042523
0042510
0009615
0005126
0002295
0002460

KEGG ID hsa:51561
mmu:83430
rno:155140

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 10

OMIM ID 605580

Rat chromosome position 7q11

Hugo ID 15488
HGNC:15488

Human chromosome position 12q13.3

Swiss-Prot Accession Q9NPF7
Q9NPF7.1
Q9EQ14
Q9EQ14.1
Q91Z84
Q91Z84.1
Q6NZ80
Q6NZ82
Q9H2A5

GenBank ID NC_000012
XM_011538477
XP_011536779
NM_016584
NP_057668
AB030001
BAA93687
AC025574
CH471054
EAW96933
CS498403
CAM82731
HI574128
CBX47553
JA104589
CCA63964
AB030000
BAA93686
AF301620
AAG37232
AJ506993
CAD45088
AY359083
AAQ89442
BC066267
AAH66267
BC066268
AAH66268
BC066269
AAH66269
BC067511
AAH67511
BC067512
AAH67512
BC067513
AAH67513
BM842783
BM851337
U38443
Q9NPF7
NC_000076
NM_031252
NP_112542
AC135859
CH466578
EDL24554
CQ878369
CAH59603
FB701193
CAS03313
HC026803
CBH19860
AF301619
AAG37231
AK043894
BC019953
AAH19953
Q9EQ14
NC_005106
NM_130410
NP_569094
AC_000075
AAHX01047152
AC109891
CH474104
EDL84876
AY055379
AAL18229
BC098907
AAH98907
Q91Z84
NC_018923
AMYH02026567
HQ447589
ADQ32075
AC_000032
AAHY01090067
AC_000144
NT_029419
NW_001838059
NW_925395
AC_000055
NT_039500
NW_001030422
NW_001084851
NW_047773
ABBA01008423

Swiss-Prot ID IL23A_HUMAN
IL23A_MOUSE
IL23A_RAT

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000110944
ENSP00000228534.4
ENST00000228534.6
ENSMUSG00000025383
ENSMUSP00000026449.1
ENSMUST00000026449.2
ENSRNOG00000003254
ENSRNOP00000004363.2
ENSRNOT00000004363.3
ENST00000228534.5
ENSP00000228534
ENST00000228534
ENSMUSP00000026449
ENSMUST00000026449
ENSRNOP00000004363
ENSRNOT00000004363

MGI ID MGI:1932410
1932410

RGD ID 620873

Unigene ID Hs.382212
Mm.125482
Hs.98309
Rn.81073

Homologene ID 12832

Shape Rhomb

IPI ID IPI00110260
IPI00209334
IPI00300835
IPI00791254