Protein MAP3K7

URN urn:agi-llid:6885
Total Entities 0
Connectivity 2267
Name MAP3K7
Description mitogen-activated protein kinase kinase kinase 7
Notes The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Osteoarthritis
Fatty Acids Block TLR Signaling in Enteroendocrine Cell
Toll-like Receptors Act through MYD88-TIRAP Signaling
NOD-like Receptors
Antiviral Signaling through Pattern Recognition Receptors
Toll-like Receptors Act through MYD88 Signaling
TLR4 Signaling in Leukocytes
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
V(D)J Recombination Activation
Immunoglobulin Class-Switch Recombination Activation
Peripheral T-Cell Tolerance
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Th17-Cell Differentiation
Toll-like Receptors in Sterile Inflammation
Toll-like Receptor Independent Sterile Inflammation
Prostaglandin E2 Receptor Signaling in Neurons
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Neutrophil Recruitment and Priming
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Endothelial Cell Activation by Cytokines
Adipokines Production by Adipocyte
IL1B Expression Targets -> Nociception
Apoptosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Dendritic Cells Function in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Dilated Cardiomyopathy
Myocardial Infarction
MAVS in Antiviral Innate Immune Response in Myocarditis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
WNT Signaling in Melanoma
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
Dendritic Cells Function in Psoriasis
Apoptotic Keratinocytes Clearance Recession in Systemic Lupus Erythematosus
Dendritic Cell Activation in Systemic Lupus Erythematosis
Th17-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Toll-like Receptors in beta-Cell
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Adiponectin in Insulin Resistance Prevention
Insulin Resistance in Myocytes Induced by Obesity
Adipose Tissue Inflammation Provokes Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
beta-Cell Destruction in Diabetes Mellitus Type 1
Adipokines Production by Adipocyte Impaired in Obesity
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
Crohn's Disease
Macrophage Dysfunction
Dendritic Cell Dysfunction in Crohn's disease
CagA Phosphorylation Independent Signaling
Dendritic Cell Function in Ulcerative Colitis
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
B-Cell Chronic Lymphocytic Leukemia
Diffuse Large-B-Cell Lymphoma
Diffuse Large-B-Cell Lymphoma ABC Subtype
Follicular Lymphoma
Hodgkin Lymphoma
Mantle Cell Lymphoma
mTOR/NF-kB/BCR Signaling Disregulation in Mantle Cell Lymphoma
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Splenic Marginal Zone Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
Osteoclast Activation in Multiple Myeloma
Multiple Myeloma
Antiphospholipid Antibodies and Endothelial Cell Interaction
T-Cell Acute Lymphoblastic Leukemia
Il17 Signaling Related Neutrophilia in Asthma
IL33 Signaling Related Eosinophilia in Asthma
TSLP Signaling in Bronchial Epithelial Cell in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
B-Cell Mediated IgE Production in Asthma
Th17-Cell Differentiation in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Airway Epithelial Cell Dysfunction
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoblast Function Decline in Gout
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
Hyper IgM Syndrome
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
IL1B Induced Arthralgia
TGFB2 Signaling Impairement in Osteoarthritis
Dendritic Cell Dysfunction in Psoriatic Arthritis
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Osteoclast Activation in Psoriatic Arthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
CD4+ T-Cell Function Decline in HIV
Apoptosis Block in Infected Cells
CD4+ T-Cell Death in HIV
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Myostatin in Skeletal Muscles in Muscular Dystrophies
Osteoclasts Function in Osteopetrosis
Bone Loss in Osteoporosis
Hyperparathyroidism, Secondary Effect
Osteoclast Activation in Postmenopause
Microglia Activation in Alzheimer's Disease
HMGB1 and IL1B in Neuroinflammation
Microglia Activation in Parkinson's Disease
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
OPTN Effects on NF-kB Signaling in Glaucoma
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Immune System Role in Otitis Media
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
T-Cell Cytotoxic Activation
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Endothelial Cell Dysfunction in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
B-Cell Receptor -> NF-kB Signaling
TLR -> ARRB2/NF-kB Signaling
gamma Globulins Expression Targets
CD22 -> NF-kB Expression Targets
CD72 -> STAT Expression Target
CD8 -> STAT Expression Targets
CD80 -> STAT Expression Targets
CD86 -> STAT Expression Targets
PECAM1 Expression Targets
NFKB Canonical Signaling Activation in Cancer
NFKB Non-Canonical Signaling Activation in Cancer
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
IL23A and IL17A Provoke Cancer-Associated Inflammation
TGFB Signaling activation by Blocking of Tumor Suppressors
NFKB Signaling Activation by Blocking of Tumor Suppressors
Apoptosis Block by Death Receptor Signaling in Cancer
Apoptosis Evasion in Cancer: Overview
Telomeric Proteins/NFKB Positive Feedback Interplay in Cancer
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
IDO1 in Cancer Immune Escape
Effector T-cell Inactivation in Cancer Immune Escape
IFNLR1-> STAT/NFKB Signaling
IL1R -> NF-kB Signaling
IL16 -> NF-kB Expression Targets
PDCD1 -> NF-kB Expression Targets
DDR1 -> NF-kB Signaling
EphrinB -> MAPK/JUN/FOS Signaling
Collagen -> NF-kB Expression Targets
WNT/Calcium non-Canonical Signaling
TNF-alpha/TNFRSF1A Signaling
JNK/MAPK Signaling
TGF-beta Signaling
BMPR2 Signaling
P38 MAPK/MAPK14 Signaling
NF-kB non-Canonical Signaling
TNF-alpha/TNFRSF1B Signaling
NF-kB Canonical Signaling
TCR -> NF-kB Expression Targets
T-Cell Receptor -> AP-1 Signaling
T-Cell Receptor -> NF-kB Signaling
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
EctodysplasinR -> LEF1 Signaling
TNFR -> NF-kB Signaling
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR4/5/7/9 -> NF-kB Signaling
TLR1/2/6 -> NF-kB Signaling
TLR -> AP-1 Signaling
pathway 4
prarg negative regulators, ps-positive
PPARG negative regulators
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of mortality
Neighbors of infarct size
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of macrophage count
Neighbors of body weight gain
Neighbors of neutrophil count
Neighbors of cell density
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of radiosensitivity
Neighbors of functional status
Neighbors of infarct area
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of overall survival
Neighbors of disease severity
Neighbors of mortality
Neighbors of infarct size
Neighbors of bacterial load
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of macrophage count
Neighbors of body weight gain
Neighbors of neutrophil count
Neighbors of cell density
Neighbors of T-cell count
Neighbors of energy expenditure
Neighbors of radiosensitivity
Neighbors of functional status
Neighbors of infarct area
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of adipocyte differentiation
Neighbors of microglial activation
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of osteoclast formation
Neighbors of cell invasion
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of hepatocyte proliferation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of cancer cell growth
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of life span
Neighbors of cell homeostasis
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of inflammation
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of pneumonia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of death
Neighbors of encephalomyelitis
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of gastric cancer
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of collagen-induced arthritis
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of neoplasm
Neighbors of atrophy
Neighbors of diet-induced obesity
Neighbors of myocardial fibrosis
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of proteinuria
Neighbors of lymph node
Neighbors of colon
Neighbors of gastrointestinal tract
Neighbors of central nervous system
Neighbors of Ras GTPase
Neighbors of GPCR
Neighbors of heat shock protein 90
Neighbors of proteasome endopeptidase complex
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
dsRNA induces innate immunity and INFs in alveolar cells
Innate immunity in Leukocytes
Dendritic Cell Activation in COVID19
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Osteoclast functional impairment in osteopetrosis
2_Chondrocyte death in osteoarthritis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
2_Podocyte dysfunction in glomerulonephritis
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
2_Pathogens stimulate mucins expression in the middle ear
3_Arterial wall inflammation and calcification in atherosclerosis
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
3_Autophagy dysfunction in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
2_Lipotoxicity in NAFLD
1_CD4+ T cell and epithelial cell response in celiac disease
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
2_HIV - induced depletion of CD4+ T-cells
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
1_CFTR expression and degradation in epithelial cells in cystic fibrosis (class I-II mutations)
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
3_Islet beta-cell destruction in T1D
2_Neuron and Schwann cell death
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
Model of PPARG signaling in psoriais (tested)
Interleukin-17 and interleukin-22 signaling in psoriasis

MedScan ID 6885
21347

LocusLink ID 6885
313121
26409
100910771
21347
93774
230048

Alias OTTHUMP00000016872
MEKK7
TGF-beta- activated kinase I
TGF1a
mitogen activated protein kinase kinase kinase TAK1
TAK1
OTTHUMP00000016870
Transforming growth factor-beta-activated kinase 1
TGF beta-activated kinase
mitogen-activated protein kinase kinase kinase VII
TGF-beta-activated kinase 1
RP1-154G14.1
mitogen-activated protein kinase kinase kinase 7
Transforming growth factor-beta-activated kinase I
OTTMUSP00000005101
Map3k7
FMD2 gene
MAPKKK7
OTTHUMP00000016871
RP23-447J12.1
OTTMUSP00000005100
OTTHUMP00000016873
CSCF
FMD2
TGF-beta activated kinase 1
mitogen activated protein kinase kinase kinase 7
B430101B05
LOC100910771
EST C87327
mitogen-activated protein kinase kinase kinase 7-like
transforming growth factor beta-activated kinase 1
C87327
TGF-beta- activated kinase 1
mitogen activated protein kinase kinase kinase 7 (predicted)

EC Number 2.7.11.25
2.7.1.-

GO ID 0005524
0004709
0000287
0004672
0004674
0030971
0097110
0038095
0007249
0007252
0007254
0002755
0050852
0007223
0000187
0000186
0007250
0043276
0043966
0070498
0070423
0043123
0043507
0051092
0002726
0032743
0016239
0016579
0002223
0051403
0007179
0016032
0005671
0008385
0005829
0010008
0005634
0005886
0004708
0000165
0001525
0006915
2001234
0060546
2000378
1902443
0001841
0018107
0046330
0006468
2000377
0005737
0014069
0005622
0050870
0045087
0034146
0035872
0016310
0034142
0006351
0007165
0002756
0043066
0006355
0097481
0006950
0005515
0034134
0034138
0035666
0008063
0034130
0034166
0038123
0038124
0016772
0034162
0046872
0005654
0016301
0016740
0016020
0002224
0000166
0008152
0004713

KEGG ID hsa:6885
rno:100910771
rno:313121
mmu:26409

MedLine Reference 12969270
15831522
16157589
16183734
17085580
10349636
10725249
10757786
10922068
11042159
11076861
11217851
11356033
12464436
12466851
12477932
12545162
12556533
12711537
12805214
12842894
14592977
15226265
15647289
15782199
15837794
15894542
15911626
16141072
16141073
16145668
16186825
16260493
16301747
16339560
16360132
16385569
16446357
16498455
16556914
16675448
16754690
16799562
16831874
16835226
16857737
16919269
16940043
8533096
10022904
10094049
10187861
10195894
10224067
10748100
10779355
10807933
10838074
10882101
10921914
11104763
11118615
11259596
11397816
11460167
11585904
11809792
11865055
12048196
12089335
12242293
12296995
12372426
12547194
12589052
12609980
12804775
12859960
12874243
14702039
14743216
14960582
15075345
15082531
15125833
15277532
15590691
15670770
15764709
15917296
16000313
16153868
16251197
16260783
16280329
16293250
16527194
16893890
17114179
3031469
7708055
8638164
9278437
9380693
9466656
9480845
9556573
9689078
14574404
15489334
16289117
17081983
17158449
17173073
17202147
17276978
17379600
17114649
17197697
17209006

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Rattus norvegicus
Mus musculus

Mouse chromosome position 4
4 A5

OMIM ID 602614
157800
617137
OMIM:602614

Rat chromosome position 5q21
9

Hugo ID 6859
HGNC:6859

Human chromosome position 6q15
6q16.1-q16.3

Swiss-Prot Accession O43318
O43318.1
P0C8E4
P0C8E4.1
B2RE27
E1P523
O43317
O43319
Q5TDN2
Q5TDN3
Q5TDT7
Q9NTR3
Q9NZ70
Q543B5
Q923A8
Q62073
Q5U0C9
Q5U0D0
Q9UG54
Q3TXG1
Q5TDM9
M3K7_HUMAN

PIR ID JC5955
JC5956

GenBank ID NC_000006
NM_145333
NP_663306
NM_003188
NP_003179
NM_145332
NP_663305
NM_145331
NP_663304
XM_006715553
XP_006715616
XM_017011226
XP_016866715
NG_011966
AL121837
AL121964
CH471051
EAW48525
EAW48526
EAW48527
EAW48528
EAW48529
DQ314875
ABC40734
AB009356
BAA25025
AB009357
BAA25026
AB009358
BAA25027
AF218074
AAF27652
AI147171
AK055901
AK299268
BAG61290
AK315774
BAG38124
AL050393
CAB43687
AL520975
BC017715
AAH17715
BM172351
BT019654
AAV38460
BT019655
AAV38461
BX648277
O43318
NC_005104
XM_006237966
XP_006238028
NM_001107920
NP_001101390
AC_000073
AABR07047779
AAHX01035853
AAHX01035854
CH473962
EDL98558
EDL98559
BC099193
P0C8E4
NP_033342
CAI19609
XM_003750753
AK046565
BAA11184
XP_006245676
CAI19610
CAI19611
XP_006538011
CAI19612
CAI19613
NM_172688
AL833781
AAHY01034689
ABBA01040553
ABBA01040554
BAC35588
Q62073
BAE34955
AK145302
XM_006537948
AC_000026
CAI23532
CAI23533
CAI23530
CAI23531
CV559615
NC_000070
AC_000138
CAM24620
NP_766276
CAM24622
CAM24621
CAM24623
NM_009316
XR_390323
D76446
XP_005248818
AK211827
NC_005108
XM_006245614
AAHY01034690
AAH06665
AK053911
AK137046
EDL05512
XP_003750801
EDL05511
AK159277
BAE23216
AK133642
NC_018917
AABR07068650
AMYH02014101
BC006665
CH466538
AABR06036336
XM_005248761
NT_007299
NW_923184
NW_001838987
AC_000049
CR604679
Q5U0C9
Q5U0D0
Q9NZ70
Q9UG54
NT_166289
NW_001030740
Q3TXG1
Q543B5
Q923A8
NW_047711
NW_001084836
XM_232855
XP_232855
XM_001062961
XP_001062961
Q5TDM9
BG067741
BG085694
NT_086697
Q5TDN2
Q5TDN3
NW_000206
NT_109315
BG080801
10720099
1167506
123787232
13879376
26343863
74192894
74205839
81909144
81916394
C87327
119568910
119568911
119568912
119568913
119568914
12643557
17389343
2924624
2924626
54696176
54696178
56203689
56203690
56203691
56203692
56203693
56204060
56204061
56204062
56204063
6562171
6746615
74753307
74756530
74756708
74756709
74761825
83699657
8978252
123230057
123230058
123230059
123230060
148673564
148673565
149045558
149045559

Swiss-Prot ID M3K7_HUMAN
M3K7_MOUSE
M3K7_RAT
Q9NZ70_HUMAN
Q923A8_MOUSE
Q543B5_MOUSE
B2RE27_HUMAN
Q5TDT7_HUMAN

Cell Localization Cytoplasm
Cell membrane

Ensembl ID ENSG00000135341
ENSP00000358338.3
ENST00000369332.7
ENSP00000358335.3
ENST00000369329.8
ENSP00000358331.3
ENST00000369325.7
ENSP00000358333.3
ENST00000369327.7
ENSRNOG00000005724
ENSRNOP00000007654.4
ENSRNOT00000007654.5
ENSMUSG00000028284
ENSP00000358331
ENSP00000358333
ENSP00000358335
ENSP00000358338
ENST00000369325
ENSMUST00000037607
ENSMUST00000080933
ENSRNOP00000007654
ENSRNOP00000007657
ENSRNOT00000007654
ENST00000369329
ENST00000369327
ENST00000369329.7
ENSMUSP00000079734
ENST00000369332
ENSMUSP00000040307
ENSRNOG00000047516

MGI ID MGI:1346877
1346877
2135559
1203726

RGD ID 1309438
6496502

Unigene ID Hs.594838
Rn.24019
Mm.258589
Hs.722892
Hs.644143
Mm.392292
Hs.290346
Rn.100643
Hs.485968
Hs.652105

Homologene ID 37743
135715
118818

Shape Sickle-vertex

IPI ID IPI00121080
IPI00218566
IPI00218567
IPI00295738
IPI00367017
IPI00241935
IPI00123967
IPI00641808
IPI00648040
IPI00649898
IPI00214313

Homo sapiens Chromosome position 6q16.1-q16.3

Ensembl Transcript ID ENST00000369332
ENST00000369329
ENST00000369325
ENST00000369327

FunctionalClass MAP kinase kinase kinase
protein binding
protein-tyrosine kinase
ATP binding
kinase
magnesium ion binding
metal ion binding
nucleotide binding
protein kinase
protein serine/threonine kinase
transferase
MAP kinase kinase

Mus musculus Chromosome position 4 A5
4

Rattus norvegicus Chromosome position 5q21

Ensembl Gene ID ENSG00000135341