Protein IL4

URN urn:agi-llid:3565
Total Entities 0
Connectivity 9899
Name IL4
Description interleukin 4
Notes The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand
ObjectType Protein

Pathway T-Cell Dependent B-Cell Activation
Immunoglobulin Class-Switch Recombination Activation
T-Cell Maturation (Hypothesis)
CD8+ T-Cell Activation
Th2-Cell Differentiation
T-Cell Receptor Signaling
Lipoxins and Resolvins in Inflammation Resolution
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Histamine Effects in Inflammation
Basophil Activation
Eosinophil Activation
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Nociception Expression Targets Signaling
CNR1/2 -> IL1B/2/4/6/10 Production
Hematopoietic Cell Lineage: B-cell (mouse)
Proteins Involved in Atherosclerosis
Proteins Involved in Myocarditis
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Genes with Mutations Associated with Atopic Dermatitis
Acute Phase in Atopic Dermatitis
Proteins Involved in Atopic Dermatitis
Atopic Dermatitis
Proteins Involved in Psoriasis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
Proteins with Altered Expression in Psoriasis
Proteins Involved in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Genes with Mutations Associated with Vitiligo
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
Proteins Involved in Diabetes Mellitus Type 1
Proteins Involved in Diabetic Neuropathy
Immune Sustem Activation in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
Proteins Involved in Graves Disease
Graves Ophthalmopathy
Immune System Activation in Hyperthyroidism
Proteins Involved in Myasthenia Gravis
Proteins Involved in Obesity
Proteins Involved in Celiac Disease
CD4+T-Cell Response in Celiac Disease
Proteins with Altered Expression in Celiac Disease
Celiac Disease
B-Cell Activation in Crohn's Disease
Macrophage Dysfunction
Proteins Involved in Inflammatory Bowel Diseases
Proteins Involved in Helicobacter Infections
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
Proteins Involved in Diffuse Large-B-Cell Lymphoma
Follicular Lymphoma
Osteoclast Activation in Multiple Myeloma
Proteins Involved in Multiple Myeloma
Proteins Involved in Hepatocellular Carcinoma
ADAM33 Role in Asthma
Eosinophil Survival in Asthma
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Exocytosis in Asthma
Goblet-Cell Related Mucus Secretion in Asthma
Club-Cell Role in Asthma
Basophil Activation in Asthma
Antigen-Presenting Cell Role in Asthma
B-Cell Mediated IgE Production in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Proteins Involved in Osteoarthritis
PTPN22 Role in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
FAS Mediated Apoptosis in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Proteins with Altered Expression in Systemic Scleroderma
Proteins Involved in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
Proteins Involved in Periodontitis
Proteins Involved in Glioblastoma
Proteins Involved in Astrocytoma
Proteins Involved in Glioma
Proteins Involved in Neuroblastoma
MBP/MOG/PLP in Immune System Activation
Proteins Involved in Multiple Sclerosis
Proteins Involved in Endometriosis
Proteins Involved in Spontaneous Abortion
Genes with Mutations Associated with Asthma
Proteins Involved in Chronic Obstructive Pulmonary Disease
Mucin Hyperproduction in Goblet and Mucous Cells
Proteins Involved in Chronic Bronchitis
Proteins Involved in Polycystic Kidney Disease
Noradrenaline/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD8 -> AP-1 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD72 -> STAT Expression Target
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> AP-1 Expression Targets
CD80 -> STAT Expression Targets
CD81 Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> STAT Expression Targets
CD86-> NFATC Expression Targets
CD86 -> NF-kB Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
Myeloid Derived Suppressor Cells in Cancer Immune Escape
Proteins with Altered Expression in Cancer Immune Escape
Insulin -> STAT Expression Targets
Insulin -> CEBPA/CTNNB/FOXA/FOXO Expression Targets
Insulin -> MEF/MYOD Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
IFNA1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL4R -> STAT Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL7 Expression Targets
IL15 Expression Targets
IL12B Expression Targets
IL3 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
PGE1 Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
NOTCH -> Expression Targets in Thymus
Elevated Receptors -> Expression Targets in Thymus
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
JAG1 Expression Targets
NOTCH Expression Targets
Adenosine Expression Targets
GNRH1 Expression Targets
CCL11 Expression Targets
NPY Expression Targets
Collagen -> NF-kB Expression Targets
PAF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> NFAT Expression Targets
TCR -> AP-1 Expression Targets
TGFB1-TGFBR1 Expression Targets
TNFSF14 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13B Expression Targets
TLR4 -> AP-1 Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
B-Cell Differentiation Inhibition by Dioxin
PPAR Psoriasis
Model of PPARG signaling in psoriasis
IFN signaling in alveolar cells
Overview. Diseases of the skin (chapter 11)
Overview. Diseases of the respiratory (chapter 9)
2_Acute phase initiation in atopic dermatitis
1_Differentiation of psoriatic T cells
1_The onset of atopic dermatitis
1_Th2 cell response in asthma
3_2_Regulation of airway surface liquid (ASL) thickness
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_Mucin hyperproduction in goblet and mucous cells in COPD
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_CD4+ T cell and epithelial cell response in celiac disease
2_Defective tolerance of autoreactive T-cell in T1D
drug-target moltransport
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Atopic Dermatitis
Genes with Mutations Associated with Psoriasis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Vitiligo
Genes with Mutations Associated with Hashimoto's Thyroiditis
Genes with Mutations Associated with Asthma
Genes with Mutations Associated with Multiple Sclerosis

Source curated
GO component

MedScan ID 3565

LocusLink ID 3565
16189
287287
24496
280824

Alias IGG1 induction factor
IL4R ligands
interleukin IL4_HUMAN
B-cell IgG differentiation factor
BSF I
b cell stimulating factor
IL4e12
interleukin IL4
RP23-188H3.4
IL4
B cell stimulating factor 1
IL IV
interleukin[4]
interleukin IV
BCGF-1
b lymphocyte stimulating factor 1
B-cell stimulatory factor 1
interleukin(4)
interleukin IL4e12
interleukin-4 receptor ligand
interleukin IL IV
interleukin 4 variant 2
B_cell stimulatory factor 1
binetrakin
MGC79402
BSF-1
IL-4 receptor ligand
OTTMUSP00000005817
Lymphocyte stimulatory factor 1
B-cell stimulatory factor I
pitrakinra
B cell growth factor 1
Lymphocyte stimulatory factor I
IL4_HUMAN
BSF1
IL-4
BCGF1
interleukin-4
B-cell growth factor 1
IL[4]
interleukin 4
Interleukin-IL4
IgG1

GO ID 0005125
0008083
0005136
0030183
0042110
0035745
0042976
0008203
0045189
0019221
0097028
0006955
0043011
0043066
1903660
2000352
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0045671
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0016239
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0042531
0050776
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0042092
0005576
0005615
0005126
0042113
0031296
0002296
0045064
0006914
0042832
0097192
0002227
0001774
0050868
2000320
0002674
0002677
2001237
0043031
0045019
0070351
0050871
0051091
0042104
0008284
0045080
0002230
2000424
0002639
0032733
0043306
0071677
1901741
0050731
0001934
1903428
0050727
0010155
0009897
0071288
0007565
0046427
1903142
0046825
0010469
0034097
0042493
0045471
0007584
0014070
0060041
0006954
0006968
0005515
0006935
0050863
0042523
0016563
0016564
0043193
0008283
0042087

KEGG ID rno:287287
hsa:3565
mmu:16189

MedLine Reference 12004164
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1983334

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus

Mouse chromosome position 11 31.97 cM
11 29.0 cM

OMIM ID 147780

Rat chromosome position 10q22

Hugo ID 6014
HGNC:6014

Human chromosome position 5q31.1

Swiss-Prot Accession D4HNR6
P05112
Q5FC01
P05112.1
P07750
P07750.1
P20096
P20096.2
Q14630
Q6NZ77
Q5SV00
Q6NWP0
Q9UPB9
Q5KT56
Q91Y50
Q6RIC4

PIR ID A60237
A30546
A25870

GenBank ID NC_000005
NM_001354990
NP_001341919
NM_000589
NP_000580
NM_172348
NP_758858
NG_023252
AC004039
AF395008
AAK71324
AF465829
CH471062
EAW62322
EAW62323
CS255762
CAJ75955
FB507239
CAV32874
FJ807883
ADD60204
GQ892002
ADN03408
GQ892003
ADN03409
GQ892004
ADN03410
GQ892005
ADN03411
GQ892006
ADN03412
GQ892007
ADN03413
GQ892008
ADN03414
GQ892009
ADN03415
GQ892010
ADN03416
GQ892011
ADN03417
GQ892012
ADN03418
GQ892013
ADN03419
GQ892014
ADN03420
GQ892015
ADN03421
GQ892016
ADN03422
GQ892017
ADN03423
HC679221
CBL86566
HH829894
CBX32734
M23442
AAA59150
X06750
CAA29925
AB102862
BAD89396
AF043336
AAC03537
AM937235
CAP72493
BC066277
AAH66277
BC066278
BC067514
AAH67514
BC067515
AAH67515
BC070123
AAH70123
CD640452
EF173851
ABM53124
JX878389
AGM38212
M13982
AAA59149
X81851
CAA57444
P05112
NC_000077
NM_021283
NP_067258
NR_027491
AC005742
AL596095
AL645741
CH466575
EDL33576
EDL33577
EDL33578
U07869
X05064
CAA28731
X05252
CAA28873
X05253
CAA28874
AA199406
AB174765
BAD83771
AF352783
AAK52901
AF359558
BC027514
AAH27514
BX529138
M13238
AAA39307
M25892
AAA39298
X03532
CAA27233
P07750
NC_005109
NM_201270
NP_958427
AC_000078
AAHX01063900
AAHX01063901
AC107611
CH473948
EDM04390
EDM04391
EDM04392
EDM04393
X53087
CAA37256
X53088
X53089
AY496861
AAR87867
X16058
CAC16091
P20096
CAI24351
AAHY01093363
AMYH02012219
AC_000033
AC_000137
AABR06063818
CAI24688
ABBA01068803
XR_427710
NC_018916
NT_034772
NW_922784
NW_001838952
AC_000048
Q5FC01
Q6NWP0
Q6NZ77
Q9UPB9
NT_096135
NW_001030461
Q5KT56
Q5SV00
Q91Y50
NW_047334
NW_001084656
Q6RIC4
NT_039530
AAH66278
NW_000039
11140161
124339
40557191
4894184
81864133
124338
1334110
1334111
14030446
20380614
309412
51827
52679
533237
56205961
56206963
57157562
81889114
81902427
81910145
119582726
119582727
124337
14600280
186337
2905624
307061
33832
42490871
42490900
45708996
45709848
47123367
58736975
673419
74721228
74721688
74736926
74737031
86476574
NT_086681
163211
266339
555896
AAA30587
AAA82730
M77120
NC_007305
NM_173921
NP_776346
NW_001495335
P30367
U14159
U14160
148701629
148701630
148701631
149052573
149052574
149052575
149052576

Swiss-Prot ID IL4_RAT
IL4_HUMAN
IL4_MOUSE
Q5FC01_HUMAN
D4HNR6_HUMAN
Q5SV00_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000113520
ENSP00000231449.2
ENST00000231449.7
ENSP00000480581.1
ENST00000622422.1
ENSP00000325190.3
ENST00000350025.2
ENSMUSG00000000869
ENSMUSP00000000889.6
ENSMUST00000000889.6
ENSMUST00000150568.7
ENSRNOG00000007624
ENSRNOP00000010029.1
ENSRNOT00000010029.3
ENST00000231449.6
ENSMUSP00000000889
ENSP00000325190
ENSMUST00000150568
ENSRNOP00000010029
ENSRNOT00000010029
ENST00000350025
ENSMUST00000000889
ENST00000231449
ENSP00000231449

MGI ID MGI:96556
96556

RGD ID 2898

Unigene ID Mm.276360
Rn.108255
Hs.73917
Bt.423

Homologene ID 491

Shape Rhomb

IPI ID IPI00217945
IPI00131815
IPI00007081
IPI00195650
IPI00454514

Microarray ID 92283_s_at
92284_r_at
92285_at
92286_g_at
AFFX-MurIL4_at

Homo sapiens Chromosome position 5q31.1

Ensembl Transcript ID ENST00000350025
ENST00000231449

FunctionalClass cytokine
interleukin-4 receptor binding
protein binding
growth factor
hematopoietin/interferon-class (D200-domain) cytokine receptor binding

Bos taurus Chromosome position 7q15-q21

Mus musculus Chromosome position 11 29.0 cM

KEGG pathway Hematopoietic cell lineage
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway

Rattus norvegicus Chromosome position 10
10q22

Ensembl Gene ID ENSG00000113520