Protein MAP2K1

URN urn:agi-llid:5604
Total Entities 0
Connectivity 3619
Name MAP2K1
Description mitogen-activated protein kinase kinase 1
Notes The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Alzheimer's Disease
Osteoarthritis
Skin Aging
Oncogene Induced Cellular Senescence
Melatonin Effects on Circadian Cycle
mTOR Signaling
mTOR Signaling Hyperfunction
High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
mTOR Signaling Activation by Taste Sensor Receptors (Rodent Model)
Leptin and CCK8 Activate Nodose Ganglia Neuron
Insulin Influence on Protein Synthesis
Insulin Influence on Glycogenesis
Insulin Synthesis in beta-Cell
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Norepinephrine Release Regulation
CRH Secretion Regulation
Insulin Signaling
Prolactin Production
POMC Secretion in adenohypophysis
Thrombopoietin Receptors Signaling in Platelet Maturation
Mineralcorticoids Secretion Regulation
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Inhibitory Receptor Signaling
Natural Killer Cell Activation through ITSM-Containing Receptors
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
MC1R in anti-Inflammatory Signaling
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Basophil Activation
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Positive Acute Phase Proteins Synthesis
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Nociception Expression Targets Signaling
Vascular Motility
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA2C/ADRB2 -> Vasoconstriction
ADRA2C/ADRB2 -> Synaptic Endocytosis
ADRB1 -> Prostaglandin Generation
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD1/5 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR7 -> IL6 Production
HTR5 -> TNF Production
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
CHRNA7 -> NOS1 Production
GABA(B)R -> Postsynaptic Inhibition
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
P2RY11/13/14 -> IL8/10 Production
Luteinizing Hormone in Oocyte Meiotic Resumption
Melatonin in Cell Survival and Antioxidant Response
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Vitamine D Deficite and Dentin Formation
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
G0/G1 Phase Transition
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Endothelial Cell Dysfunction in Arterial Hypertension
Aldosterone Synthesis Chronic Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Contraction Due Vasospasm
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
IL17 Signaling in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
Adiponectin Synthesis Declines in Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hyperparathyroidism, Neonatal Severe
RET1 Mutation in Hyperparathyroidism
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
Graves Ophthalmopathy
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Myocyte Dysfunction in Hypoparathyroidism
Hypoparathyroidism, Primary
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TRPM7/8 in Pancreatic Adenocarcinoma
TGFBR Signaling in Pancreatic Neoplasms
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
Eosinophil Activation and Degranulation in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Neutrophil Degranulation via FPR1/IL8
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Antigen-Presenting Cell Role in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Ovulation Block
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
WHIM Syndrome
Dentin Formation Disruption
CCR5 Signaling in Macrophages
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Cowden Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Synaptic Exocytosis in Dementia
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
MIF Role in Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
TRPM8 Effects in Prostate Cancer (Hypothesis)
Proteins Involved in Cataract
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
PGF2-alpha Effect on Treatment
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Alveolar Macrophage Negative Regulation Declined in COPD
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Polycystins Mutation Effects in Cystic Kidney Disease
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Sertoli Cells Dysfunction Causes Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
GLP1R -> ARRB1 Signaling
AGTR1 -> ARRB1/ARRB2 Signaling
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CHRNA7 -> CREB Signaling
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGF -> NCOR2 Expression Target
EGFR -> NCOR2 Signaling
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF1 -> NCOR2 Expression Target
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF23 -> NCOR2 Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF2 -> NCOR2 Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
GCG Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
Genes with Mutations in Cancer-Associated Sustaining of Proliferative Signaling
G0/G1 Cell Cycle Phase Transition Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Treg Cells Promote Immunosuppression in Cancer Immune Escape
EZH2 Methyltransferase Role in Cancer
HCAR1/HCAR2 -> MAPK Signaling
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
AGER -> CREB/SP1 Signaling
NCAM1 -> CREB/ELK/SRF/MYC Signaling
CD19 -> JUN/ELK Signaling
PECAM -> SP1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
InsulinR -> ELK/SRF/SREBF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
CTGF -> NCOR2 Expression Target
ICAM1 Expression Targets
IL6R -> CEBP/ELK/SRF Signaling
IL2R -> ELK/SRF/MYC Signaling
IL1R -> NF-kB Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL16 -> AP-1 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
S1P Expression Targets
PGE1 Expression Targets
MTNR1 Signaling
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
Adenosine Expression Targets
OR1A1 -> GNAS Signaling
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
FIGF -> NCOR2 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
MERTK Signaling
Ras Signaling
TGF-beta Signaling
AMPK Signaling
AXL Receptor Tyrosine Kinase Signaling
KRAS Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
HRAS Signaling
ERK/MAPK Canonical Signaling
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> NCOR2 Expression Target
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pathway 3
ace2
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Inflammation in keratinocytes in the pathology of acne
2_Hyperseborrhea in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Osteoblast-mediated bone demineralization
1_Formation of cysts in polycystic kidney disease
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
1_Local estrogen production stimulates ectopic endometrium proliferation
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_1_Eosinophilia and neutrophilia in asthma: eosinophil migration and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
1_1_Insulin synthesis and secretion: insulin processing and storage
4_1_Insulin resistance: insulin signaling
3_Islet beta-cell destruction in T1D
1_Microangiopathy in diabetic neuropathy
2_1_General pathways of thyroid hormone signaling
Model of PPARG signaling in psoriais (tested)
public list
New Pathway
HRAS->RAF->MAPK1/3
KRAS->RAFs->MAPK1/3
NRAS->RAFs->MAPK1/3
mapk1
New Pathway
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Cowden Syndrome
Genes Associated with Syndromic Epilepsy

Source GO component
curated

MedScan ID 5604

LocusLink ID 5604
26395
170851
336276
19101
336209
533199
406728
326395

Alias MAPKK I
MPK I
MAPK kinase I
MAP kinase kinase 1
MAP kinase kinase I
ERK kinase 1
MAP kinase/Erk kinase I
MAP kinase kinase 1 , splice form A
MAP2K1
MAPK kinase 1
MAP kinase/Erk kinase 1
PRKMK I
ERK activator kinase I
mitogen activated protein kinase kinase 1
OTTMUSP00000018355
MPK1
MAPK/ERK kinase I
protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Map2k I
protein kinase, mitogen activated, kinase 1, p45
MKK I
PRKMK1
MPK1_HUMAN
MKK1
ERK activator kinase 1
ERK kinase I
MAPK/ERK kinase 1
Dual specificity mitogen-activated protein kinase kinase I
MAPKK1
mitogen-activated protein kinase kinase I
Dual specificity mitogen-activated protein kinase kinase 1
MEK1
MEK I
CFC3
MAPKK 1
MEK 1
MEKK1
mitogen-activated protein kinase kinase 1
PRKMK1s
MAPKK1s
Edpm9
PRKMK Is
Map3k1
mitogen-activated
Estrogen-dependent pituitary mass QTL 9
MAPKKK1
protein kinase, mitogen-activated, kinase I
oestrogen-dependent pituitary mass qtl, chromosome 9
MAPKK Is
kinase 1
Estrogen-dependent pituitary mass QTL, Chromosome 9
kinase 1 (MAP kinase kinase 1)
Estrogen-dependent pituitary mass QTL IX
protein kinase, mitogen-activated, kinase 1
protein kinase
kinase, mitogen activated, kinase 1, p
Mekk
oestrogen-dependent pituitary mass qtl, chromosome IX
MEK1(MAP2K1)

EC Number 2.7.12.2
2.7.1.-

GO ID 0005524
0004708
0008022
0047485
0004672
0043539
0004674
0004712
0004713
0097110
0060020
0070371
0000165
0000187
0032147
0007050
0048870
0090398
0021697
0006935
0060502
0060324
0007507
0030216
0060711
0008285
0010629
0030182
0018107
0018108
0060674
0070374
0050772
0010628
1903800
0071902
0045893
0006468
0090170
0048679
2000641
0032872
0007165
0023014
0031098
0048538
0030878
0060440
0005794
0005737
0005829
0005769
0005783
0005925
0005770
0005815
0005739
0005634
0005886
0017016
0016301
0031435
0000166
0019901
0016740
0048313
0008283
0042593
0060425
0032402
0000278
0034111
1903298
0048812
0016310
2001171
0043547
0046579
0010508
0045597
0030335
0045933
0032968
0051291
0070372
0098696
0003056
0048678
0051384
0006979
0070328
0047496
0030424
0005938
0005856
0030425
0032839
0098978
0016020
0005874
0043204
0048471
0014069
0035556
0004702
0004728
0098779
0006928
0035897
0070062
0007067
0001932
0042981
0007346
0038095
0002755
0002756
0007265
0035666
0000186
0007411
0007173
0008543
0045087
0008286
0048011
0009405
0032320
0007264
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0048010
0016772
0035335
0005816
0008063
0034130
0033267
0007243
0005625
0008152
0016311
0010149
0005515
0043406
0005575

KEGG ID hsa:5604
mmu:26395
rno:170851

MedLine Reference 17461449
8462694
8131746
16481589
12270934
15557124
12594221
8297798
1381507
15890671
10489373
12832465
10780709
15302887
9779826
11823456
8168826
9325171
15069060
10395327
11579140
12792650
16424016
12466851
17498664
12697810
15538402
15572374
8626767
1411546
11217851
15021912
11076861
15304090
9149902
12663500
9558095
12807433
14672918
10570282
8388392
15757891
11134045
7914033
8529659
15657353
15917294
1281467
17182854
12370306
15240686
16861903
12689928
15020233
14656894
17366577
12609978
11604401
17192257
12244094
15701678
7969158
17197157
12063167
14627958
10725249
9440696
7957875
8602223
16737746
8602221
15353548
15292274
16086581
10982368
10209122
12695496
7601337
17038630
11841548
15657590
15615716
12167619
15665520
10523642
17054908
15979847
11042159
14594209
8157000
12531514
11409852
11044099
12917419
15469737
16199873
16463380
15118098
15284233
15782199
17490600
11352917
9841871
16439621
9621077
10828601
17603482
8406028
8226933
9223324
10997882
10806207
15159407
15145949
9852579
9733512
12875843
12876277
12788225
16686604
11266467
15004527
14563325
16913865
15753041
11226259
16820947
17183546
16931773
11104681
12663662
9553107
10536014
16761309
9465908
10757792
9208850
12839928
12482669
16887817
15489334
15509711
11222509
8385802
11260070
12975377
7624324
15737734
17419998
15297310
17260965
16239230
16141073
16141072
10912793
12456688
7731720
16728640
10748187
12532330
17396120
9806642
9155017
11535599
15647843
10917603
8394352
1379797
14963006
11278389
11891225
16313339
12401521
10799874
16148006
15543157
15305288
15782137
16957420
10716983
12032872
12612059
8380494
70317
12612072
17202850
9563949
11684694
11823472
15546878
11044439
12477932
12522145
10838075
10349636
14581471
10509564
8632902
14871928
11101507
11872750
16162927
8621729
9351825
12556561
11822869
11741894
12522135
12682854
8939914
15888452
11948406
10848576
15299019
17101779

CellType hematopoietic cell
endometrial stromal cell
squamous cell
airway epithelial cell
trophoblast
germinal center B-cell
muscle cell
Purkinje cell
neuroglia
epidermis cell
Leydig cell
neuron
ovary follicle cell
kidney tubule cell
exocrine cell
transitional epithelial cell
smooth muscle myocyte
hepatocyte
decidual cell
macrophage
pneumocyte
glandular cells
lymphoid tissue
hematopoietic cells
cells in endometrial stroma
squamous epithelial cells
respiratory epithelial cells
cells in white pulp
cells in granular layer
trophoblastic cells
cells in molecular layer
germinal center cells
myocytes
Purkinje Cells
cells in seminiferus ducts
non-germinal center cells
glial cells
epidermal cells
Leydig Cells
neuronal cells
cells in glomeruli
follicle cells
cells in tubules
ovarian stroma cells
exocrine glandular cells
urothelial cells
smooth muscle cells
islets of Langerhans
bile duct cells
cells in red pulp
Hepatocytes
decidual cells
Macrophages
Pneumocytes

Tissue myocardium
mouth mucosa
skeletal muscles
smooth muscle
lymphoid tissue
colon
Appendix
duodenum
bone marrow
epididymis
breast
uterus, post-menopause
esophagus
bronchus
spleen
fallopian tube
Cerebellum
uterus, pre-menopause
stomach, lower
Placenta
gall bladder
stomach, upper
Prostate
lymph node
heart muscle
vagina
testis
rectum
hippocampus
cerebral cortex
vulva/anal skin
Salivary gland
nasopharynx
thyroid gland
seminal vesicle
oral mucosa
Kidney
tonsil
skeletal muscle
Ovary
Skin
lateral ventricle
small intestine
Pancreas
urinary bladder
Liver
parathyroid gland
Lung
cervix, uterine
Adrenal gland

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Danio rerio
Bos taurus
Human

Mouse chromosome position 9 34.55 cM
9 36.0 cM

OMIM ID 176872
615279
163950
115150
OMIM:176872
61385

Rat chromosome position 8q24

Hugo ID 6840
HGNC:6840

Human chromosome position 15q22.31
15q22.1-q22.33

Swiss-Prot Accession A4QPA9
Q02750
B4DFY5
H3BRW9
Q02750.2
P31938
Q3TMJ8
P31938.2
Q01986
Q01986.2
Q5EBD5
Q3TMW4
Q3U3F4
Q3UK05
Q9JJE1
MP2K1_HUMAN
MP2K1_MOUSE
MP2K1_RAT
Q3TMJ8_MOUSE
A4QPA9_HUMAN

PIR ID A45100
I59571
JN0840

GenBank ID NC_000015
NM_002755
NP_002746
XM_017022411
XP_016877900
XM_011521783
XP_011520085
XM_017022412
XP_016877901
XM_017022413
XP_016877902
NG_008305
AC011276
AC055855
AC116913
AF190498
CH471082
EAW77765
EAW77766
EAW77767
EAW77768
EAW77769
AK022276
AK291500
BAF84189
AK294322
BAG57596
AK312356
BC137459
AAI37460
BC139729
AAI39730
BE856741
BG709050
CA419665
DA653983
L05624
AAA36318
L11284
Q02750
NC_000075
XM_006511196
XP_006511259
NM_008927
NP_032953
AC160118
AY902345
AAY21055
CH466522
EDL26058
AB041567
BAA95051
AK146233
BAE26999
AK146931
BAE27542
AK154793
BAE32832
AK165664
BAE38326
AK165894
BAE38443
AK167336
BAE39437
AK181307
AK190957
AK192193
AK192210
AK193287
AK193946
AK194551
AK196845
AK197193
AK199082
AK199200
AK199288
AK200800
AK203410
AK203853
AK214848
BC051137
BC054754
AAH54754
BY698931
L02526
AAA39523
P31938
NC_005107
NM_031643
NP_113831
XM_017595427
XP_017450916
AC_000076
AABR07070404
AABR07070405
AABR07070406
AABR07070407
AABR07070408
AABR07070409
AABR07070410
AABR07070411
AABR07070412
AABR07070413
AABR07070414
AABR07070415
AABR07070416
AABR07070417
AABR07070418
AABR07070419
AABR07070420
AABR07070421
AABR07070422
AABR07070423
AABR07070424
AABR07070425
AABR07070426
AABR07070427
AABR07070428
AABR07070429
AABR07070430
AAHX01055170
AAHX01055171
AAHX01055172
AAHX01055173
CH473975
EDL95791
AI603089
BC089772
AAH89772
D13341
BAA02603
D14591
BAA03441
FQ213946
X62313
CAA44192
Z16415
CAA78905
Q01986
NC_018926
AMYH02030645
AMYH02030646
AMYH02030647
AMYH02030648
AMYH02030649
AC_000031
AAHY01078835
AAHY01078836
AAHY01078837
AAHY01078838
AAHY01078839
AAHY01078840
XM_005254541
XP_005254598
XM_006720608
XP_006720671
AC_000147
ABBA01038819
ABBA01038820
ABBA01038821
ABBA01038822
XM_006511197
XP_006511260
XM_005254540
XP_005254597
AABR06055284
AABR06055285
NT_010194
NW_001838218
NW_925884
AC_000058
CR604502
CR621481
NT_039474
NW_001030907
Q3TMJ8
Q3TMW4
Q3U3F4
Q3UK05
Q9JJE1
NW_047799
NW_001084873
59808149
59808148
74191215
220811
266566
220812
199124
199123
37540936
BC052120
307183
BX927065
74191750
74227056
303803
24475715
82226062
AAH97064
AU041108
AW282020
119598175
56628
119598172
119598171
119598174
56629
119598173
400275
123791419
400274
NC_007308
111308433
AAH52120
XP_612526
32451982
32451983
51472784
286228
Q5EBD5
BC097064
51765023
29835265
29835266
62910170
NW_000353
5579478
188568
188569
BC119886
13928886
AW281751
CAK04706
123796627
148694111
123790854
CT863714
34865068
AAH51137
NW_001492790
407861
407860
81871107
82188372
Q4V947
346266
Q80XD2
7670398
7670399
NM_213419
66910416
NW_001512924
Q7ZTX6
AAI19887
74226698
6678793
6678794
149041950
NT_086827
Q0VD16
Q1LUY7
14589898
123888458
33859656
148726469
30353821
NP_998584
NC_007113
81917507
XM_612526
141796928
123790130
AW281434
74147303
122143526
94733356
CAN88104
81909568
74139093

Swiss-Prot ID MP2K1_HUMAN
MP2K1_MOUSE
MP2K1_RAT
A4QPA9_HUMAN
Q3TMJ8_MOUSE

Cell Localization Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Spindle pole body
Nucleus
Membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body

Ensembl ID ENSG00000169032
ENSP00000302486.4
ENST00000307102.9
ENSP00000456438.1
ENST00000566326.1
ENSMUSG00000004936
ENSMUSP00000005066.8
ENSMUST00000005066.8
ENSRNOG00000010176
ENSRNOP00000013933.4
ENSRNOT00000013933.6
ENSP00000302486
ENST00000307102
ENSMUSP00000005066
ENSMUST00000005066
ENSRNOP00000013933
ENSRNOT00000013933

MGI ID MGI:1346866
1346866
102562

RGD ID 70495
61385

Unigene ID Hs.145442
Mm.248907
Rn.5850
Mm.435672
Mm.426740
Mm.465469
Dr.81130
Mm.456154
Bt.29185
Hs.132311
Dr.107100

Homologene ID 2063

Shape Sickle-vertex

IPI ID IPI00219604
IPI00797850
IPI00231247
IPI00466610

Microarray ID L11284_at
l04485mrna_s_at
1844_s_at
MB170
335
d14591_s_at
l02526_s_at
202670_at
92585_at
1416351_at
OR0879
A_14_P100756
rc_ai178835_at
A_42_P638191
A_14_P118260
R724
A_23_P20248
A_51_P241074
60945_at
1130_at
L05624_s_at
OH7696
99707_at
A_32_P189110
A_32_P406652
L05624
214592_s_at
M347
OH7707
1367760_at
A_14_P128795

Homo sapiens Chromosome position 15q22.1-q22.33

Ensembl Transcript ID ENST00000307102

ENSEMBL ENSG00000169032

FunctionalClass MAP kinase kinase
kinase
protein kinase
protein binding
protein-tyrosine kinase
nucleotide binding
protein serine/threonine kinase
transferase
ATP binding

Hugo Symbol MAP2K1

Bos taurus Chromosome position 10

Mus musculus Chromosome position 9 36.0 cM

ProteinAtlas SubcellularLocation Main location: Plasma membrane;Cytoplasm; Other location: ; Expression type: Staining; Reliability: Supportive

Rattus norvegicus Chromosome position 8q24

Ensembl Gene ID ENSG00000169032

ProteinAtlas NormalTissue Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: duodenum; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: uterus
post-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in white pulp; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: colon; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain
Tissue: stomach
lower; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Negative; Expression type: Staining; Reliability: Uncertain
Tissue: lung; Cell type: pneumocytes; Level: Low; Expression type: APE; Reliability: High
Tissue: adrenal gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: appendix; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: appendix; Cell type: lymphoid tissue; Level: Medium; Expression type: APE; Reliability: High
Tissue: bone marrow; Cell type: hematopoietic cells; Level: High; Expression type: APE; Reliability: High
Tissue: breast; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: cells in granular layer; Level: Medium; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Medium; Expression type: APE; Reliability: High
Tissue: cerebellum; Cell type: Purkinje cells; Level: High; Expression type: APE; Reliability: High
Tissue: cerebral cortex; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: cervix, uterine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: colon; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: duodenum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: epididymis; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: fallopian tube; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: gall bladder; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: heart muscle; Cell type: myocytes; Level: None; Expression type: APE; Reliability: High
Tissue: hippocampus; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: hippocampus; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: kidney; Cell type: cells in glomeruli; Level: Low; Expression type: APE; Reliability: High
Tissue: kidney; Cell type: cells in tubules; Level: Medium; Expression type: APE; Reliability: High
Tissue: lateral ventricle; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: liver; Cell type: bile duct cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: liver; Cell type: hepatocytes; Level: None; Expression type: APE; Reliability: High
Tissue: lung; Cell type: macrophages; Level: Medium; Expression type: APE; Reliability: High
Tissue: lymph node; Cell type: germinal center cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: lymph node; Cell type: non-germinal center cells; Level: Low; Expression type: APE; Reliability: High
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: ovary; Cell type: follicle cells; Level: Low; Expression type: APE; Reliability: High
Tissue: ovary; Cell type: ovarian stroma cells; Level: Low; Expression type: APE; Reliability: High
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: pancreas; Cell type: islets of Langerhans; Level: Low; Expression type: APE; Reliability: High
Tissue: parathyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: placenta; Cell type: decidual cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: placenta; Cell type: trophoblastic cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: prostate; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: rectum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: salivary gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: seminal vesicle; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: skeletal muscle; Cell type: myocytes; Level: None; Expression type: APE; Reliability: High
Tissue: skin; Cell type: epidermal cells; Level: Low; Expression type: APE; Reliability: High
Tissue: small intestine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: None; Expression type: APE; Reliability: High
Tissue: spleen; Cell type: cells in red pulp; Level: Medium; Expression type: APE; Reliability: High
Tissue: spleen; Cell type: cells in white pulp; Level: Low; Expression type: APE; Reliability: High
Tissue: stomach, lower; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: stomach, upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Medium; Expression type: APE; Reliability: High
Tissue: testis; Cell type: Leydig cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: thyroid gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: germinal center cells; Level: High; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: non-germinal center cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: tonsil; Cell type: squamous epithelial cells; Level: High; Expression type: APE; Reliability: High
Tissue: urinary bladder; Cell type: urothelial cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: None; Expression type: APE; Reliability: High
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: High
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Low; Expression type: APE; Reliability: High
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: High
Tissue: vagina; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: High
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Low; Expression type: APE; Reliability: High

LocatorString pmftq:achondroplasia
gscquery:achondroplasia