Protein IL12B

URN urn:agi-llid:3593
Total Entities 0
Connectivity 2324
Name IL12B
Description interleukin 12B
Notes This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Primary Cell Localization Extracellular
Class Ligand

Pathway Toll-like Receptors Act through MYD88-TIRAP Signaling
Dectin-1 (CLEC7A) Signaling
TLR4 Signaling in Leukocytes
CD8+ T-Cell Activation
Th1-Cell Differentiation
Toll-like Receptors in Sterile Inflammation
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AHR Signaling in M1 Macrophages Function
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Dendritic Cells Function in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Inflammatory Reaction in Acne Vulgaris
Atopic Dermatitis
Proteins Involved in Psoriasis
Genes with Mutations Associated with Psoriasis
T-Cells Differentiation Block in Psoriasis
Dendritic Cells Function in Psoriasis
Th1-Cell Function in Systemic Lupus Erythematosus
Neutrophil and Macrophage Function in Systemic Lupus Erythematosus
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Toll-like Receptors in beta-Cell
Macrophage Function in Diabetes Mellitus Type 1
TLR7 and TLR9 in Plasmacytoid Dendritic Cell
Proteins Involved in Diabetes Mellitus Type 1
Conventional Dendritic Cell Role in Diabetes Mellitus Type 1
Proteins Involved in Hashimoto's Thyroiditis
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Th17-Cell Activation in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
Dendritic Cell Dysfunction in Crohn's disease
DupA Induced IL12 Production in Helicobacter Pylori Infection
Dendritic Cell Function in Ulcerative Colitis
Follicular Lymphoma
Il17 Signaling Related Neutrophilia in Asthma
Th17-Cell and Th1 Immune Responsein Psoriatic Arthritis
Proteins Involved in Psoriatic Arthritis
Genes with Mutations Associated with Psoriatic Arthritis
Proteins with Altered Expression in Psoriatic Arthritis
Proteins Involved in Glioblastoma
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
CD8 -> STAT Expression Targets
CD80 -> STAT Expression Targets
CSF2 -> STAT Expression Targets
ADCYAP1 Expression Targets
IL12R -> STAT Signaling
IL23R -> STAT3/NF-kB Signaling
IL12R -> NF-kB/NFATC Signaling
IL12B Expression Targets
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
Immunoglobulin Superfamily -> Expression Targets in Lymphoid System and Blood
CD40 -> Expression Targets in Thymus
CD40 -> Expression Targets in Lymph Node
Elevated Receptors -> Expression Targets in Thymus
PRL/PRLR Expression Targets
PRL/GHR -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
TCR -> CREB/CREBBP/ATF Expression Targets
TCR -> NF-kB Expression Targets
TCR -> NFAT Expression Targets
TCR -> STAT Expression Targets
TCR -> AP-1 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TNF -> NF-kB Expression Targets
CD40LG -> STAT Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TLR3 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR7 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
TLR9 Expression Targets
ROS in Triggering Vascular Inflammation
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of mortality
Neighbors of survival rate
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of morbidity
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of T-cell count
Neighbors of skin thickness
Neighbors of disease exacerbation
Neighbors of mortality
Neighbors of survival rate
Neighbors of bacterial load
Neighbors of graft survival
Neighbors of therapeutic efficacy
Neighbors of lethality
Neighbors of recurrence-free survival
Neighbors of tumor response
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of morbidity
Neighbors of cancer risk
Neighbors of cancer incidence
Neighbors of T-cell count
Neighbors of skin thickness
Neighbors of cell development
Neighbors of immune response
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of immunity
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of cell count
Neighbors of pregnancy
Neighbors of neutrophil recruitment
Neighbors of cell migration
Neighbors of hepatic regeneration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of hemopoiesis
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of neuroprotection
Neighbors of cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cell differentiation
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of leukocyte infiltration
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of encephalomyelitis
Neighbors of autoimmune disease
Neighbors of dermatitis
Neighbors of heart disease
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of experimental autoimmune encephalomyelitis
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of collagen-induced arthritis
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of cancer
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of respiratory hypersensitivity
Neighbors of liver disease
Neighbors of allograft rejection
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of monocyte
Neighbors of alveolar macrophage
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of microglia
Neighbors of mononuclear cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of neutrophil
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of mononuclear phagocyte
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of myeloid cell
Neighbors of stem cell
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of leukocyte
Neighbors of insulin-secreting cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of spleen cell
Neighbors of conventional dendritic cell
Neighbors of antigen-presenting cell
Neighbors of phagocyte
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of lymph node cell
Neighbors of lung
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of gastrointestinal tract
Neighbors of bone
Neighbors of brain
Neighbors of islets of Langerhans
Neighbors of pancreas
Neighbors of spleen
Neighbors of alveolus
Neighbors of cornea
Neighbors of lymph node of mesentery
Neighbors of thymus gland
Neighbors of draining lymph node
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of ovalbumin
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of histone deacetylase
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of NOS
Neighbors of proteasome endopeptidase complex
Neighbors of histone H3
Neighbors of alpha2 adrenoceptor
Neighbors of PP2A
Neighbors of SAPK
Neighbors of phospholipase
Neighbors of CD3 complex
Neighbors of TLR1/2 heterodimer
Neighbors of TORC1
Neighbors of histone
Neighbors of neuropeptides
Neighbors of histone acetyltransferase
Neighbors of caspase
comon ps_pos, pprarg_neg targets
1_Inflammation in keratinocytes in the pathology of acne
1_Differentiation of psoriatic T cells
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
Figure 4_Diabetes mellitus Type 1: conventional dendritic cell
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Psoriasis
Genes with Mutations Associated with Inflammatory Bowel Diseases
Genes with Mutations Associated with Psoriatic Arthritis

MedScan ID 3593

LocusLink ID 3593
16160
64546

Alias Interleukin-12 beta
BHR I
cytotoxic lymphocyte maturating factor 2
interleukin IL23, subuint p40
IL23, subuint p40
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
BHR1
IL-12/23 p40
interleukin-12 p40 subunit
interleukin 12 beta subunit
IL-12 p40
I12B_MOUSE
IL12B
interleukin IL-12 p40
Bronchial hyperresponsiveness-1 (bronchial asthma)
natural killer cell stimulatory factor-2
RP23-388G23.1
interleukin 12B
bronchial hyperresponsiveness 1
Cytotoxic lymphocyte maturation factor 40 kDa subunit
cytotoxic lymphocyte maturating factor II
cytotoxic lymphocyte maturating factor 2, p40
natural killer cell stimulatory factor, 40 kD subunit
bronchial hyperresponsiveness-I
cytotoxic lymphocyte maturation factor II
interleukin 12, p40
OTTMUSP00000005619
bronchial hyperresponsiveness I
I12B
Cytotoxic lymphocyte maturating factor 40 kDa subunit
interleukin IL12, subunit p40
cytotoxic lymphocyte maturation factor 2, p40
CLMF P40
interleukin IL-12-specific subunit p40
NK cell stimulatory factor chain II
CLMF2
cytotoxic lymphocyte maturation factor 2
Interleukin IL12 beta
natural killer cell stimulatory factor II
I12B_HUMAN
interleukin IL12b
IL-23 p40
bronchial hyperresponsiveness-1
NKSF2
OTTHUMP00000160820
IL12, subunit p40
NK cell stimulatory factor chain 2
IL-23 subunit p40
interleukin 12 subunit p40
interleukin-12 subunit beta
IL-12-specific subunit p40
IL-12 p40 subunit
CLMF
NKSF
IMD28
IMD29
IL-12B
IL-12 subunit p40
interleukin-12 beta chain
p40
Il12p40
Il-12p40
Il12
interleukin-12 p40

GO ID 0005125
0019955
0004896
0008083
0042164
0005143
0045519
0046982
0042803
0035744
0042088
0042093
0007050
0016477
0008283
0071346
0071222
0019221
0050829
0042832
0051607
0042095
0035722
0038155
0030101
0002323
0044130
0002862
0032693
0032700
0048662
1901224
0051135
0051142
0001916
0042102
0002827
2000330
2000318
0042104
0010536
0045785
0002230
0032725
0050729
0045078
0032729
0032733
0032735
0032740
0050671
0043382
0032946
0032816
0002860
0032819
0045672
0034393
0034105
0032760
0042531
0042035
0042509
0010224
0019233
0019953
0005829
0005788
0009897
0005576
0005615
0043514
0070743
0031906
0043235
0005126
0007166
0010033
0009986
0005737
0016020
0032609
0010469
0042346
0010535
0042517
0042520
0042523
0042510
0004871
0007165

KEGG ID hsa:3593
mmu:16160
rno:64546

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 11 25.94 cM
11 19.0 cM

OMIM ID 161561
614890
600807
209950
177900

Rat chromosome position 10q21

Hugo ID 5970
HGNC:5970

Human chromosome position 5q33.3
5q31.1-q33.1

Swiss-Prot Accession P29460
P29460.1
P43432
Q3ZAX5
P43432.1
Q9R278
E9PU71
Q9QUM1
Q8N0X8
Q62712

PIR ID A38957
I72789

GenBank ID NC_000005
NM_002187
NP_002178
NG_009618
AC011418
AF512686
AAM34792
AY008847
AAG32620
AY064126
CH471062
EAW61576
JA104591
CCA63965
KP140671
AJQ18452
KP140688
KP140689
KP140690
KP140691
KP140692
KP140693
KP140694
KP140695
KP140699
KP140700
U89323
AF180563
AAD56386
AY046592
AAL05890
AY046593
AAL05891
BC067498
AAH67498
BC067499
AAH67499
BC067500
AAH67500
BC067501
AAH67501
BC067502
AAH67502
BC074723
AAH74723
EF173865
ABM53138
M65272
AAA35695
M65290
AAA59938
P29460
NC_000077
NM_001303244
NP_001290173
AH004859
AAB37383
AL607030
AL669944
CH466575
EDL33847
EDL33848
D63333
AF128214
AAF22555
AF128215
AAF22556
AK162981
BAE37146
BC103608
AAI03609
BC103609
AAI03610
BC103610
AAI03611
BC103614
AAI03615
BY154173
M86671
AAA39296
P43432
NC_005109
XM_006246147
XP_006246209
NM_022611
NP_072133
AC_000078
AABR07029474
AAHX01063521
CH473948
EDM04146
EDM04147
AF133197
AAD24190
U16674
AAA52229
NC_018916
AMYH02012586
HQ447568
ADQ32054
AC_000033
AAHY01092921
AC_000137
ABBA01044239
XM_006532306
XP_006532369
NM_008352
NP_032378
S82421
S82422
S82424
S82425
S82426
CAM20288
CAM22832
NT_023133
NW_001838954
NW_922784
AC_000048
Q8N0X8
NT_096135
NW_001030461
Q3ZAX5
NW_047334
NW_001084656
Q62712
Q9R278

Swiss-Prot ID IL12B_HUMAN
IL12B_MOUSE
Q9R278_RAT
Q3ZAX5_MOUSE

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000113302
ENSP00000231228.2
ENST00000231228.2
ENSMUSG00000004296
ENSMUSP00000099860.3
ENSMUST00000102796.9
ENSRNOG00000004380
ENSRNOP00000005898.5
ENSRNOT00000005898.6
ENSP00000231228
ENST00000231228
ENSMUSP00000099860
ENSMUST00000102796
ENSRNOP00000005898
ENSRNOT00000005898

MGI ID MGI:96540
96540

RGD ID 628704

Unigene ID Hs.674
Mm.239707
Rn.48686

Homologene ID 1648

Shape Rhomb

IPI ID IPI00120356
IPI00021798
IPI00207823