Protein STAT4

URN urn:agi-llid:6775
Total Entities 0
Connectivity 1224
Name STAT4
Description signal transducer and activator of transcription 4
Notes The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Primary Cell Localization Nucleus
Class Transcription factor

Pathway CD8+ T-Cell Activation
Th1-Cell Differentiation
Th1-Cells Activation and Proliferation in Atherosclerosis
Lymphocyte Mediated Myocardial Injury in Myocarditis
Proteins Involved in Myocarditis
Atopic Dermatitis
T-Cells Differentiation Block in Psoriasis
Th1-Cell Function in Systemic Lupus Erythematosus
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
CD4+T-Cell Response in Celiac Disease
Th1-Cell Activation in Crohn's Disease
Proteins Involved in Ulcerative Colitis
Proteins Involved in Rheumatoid Arthritis
IL12 Antitumor Effect is Blocked in Cancer
IL27R -> STAT Signaling
IL12R -> STAT Signaling
UrokinaseR -> STAT Signaling
NOTCH -> Expression Targets in Thymus
Elevated Receptors -> Expression Targets in Testis
PPAR Psoriasis
Model of PPARG signaling in psoriasis
New Pathway (3)
Figure 3_Mixed network of dexamethasone targets
Figure 3_Mixed network of dexamethasone targets
1_Differentiation of psoriatic T cells
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
4_1_Polymorphisms associated with inflammatory bowel diseases
Differentiation of psoriatic T cells

Group Genes with Mutations Associated with Psoriasis
Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Assosiated with Rheumatoid Arthritis

MedScan ID 6775

LocusLink ID 6775
20849
367264

Alias signal transducer and activator of transcription 4
transcription factor STAT4
STAT4
signal transducers and activators of transcription 4
OTTHUMP00000163553
SLEB11
STAT4 transcription factor
STA4_MOUSE
signal transducer and activator of transcription 4 variant 3
Systemic lupus erythematosus, susceptibility to, 11
signal transducer and activator of transcription IV

GO ID 0001228
0003700
0000981
0000978
0007259
0019221
0006952
0035722
0038114
0038155
0070757
0045944
0042127
0043434
0005829
0005654
0005634
0003677
0043565
0008283
0071310
0010628
0006468
0006355
0007165
0005737
0071345
0071407
0061326
0006351
0000977
0004871
0000979
0042803
0000983
0005164
0035458
0060333
0046725
0043124
0016525
0001937
0033209
0000790
0005730
0048471
0005509
0003690
0019899
0031663
0043330
0009617
0032496

KEGG ID hsa:6775
mmu:20849
rno:367264

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 1 26.67 cM
1 25.9 cM

OMIM ID 600558
612253
180300
152700

Rat chromosome position 9q22

Hugo ID 11365
HGNC:11365

Human chromosome position 2q32.2-q32.3

Swiss-Prot Accession Q14765
Q14765.1
P42228
Q3V157
P42228.1
Q66HB2
Q96NZ6
Q53RU2
Q53S87
Q59GR6
Q3U098
Q4G0C1
Q8C2A4
O70428

PIR ID A56047

GenBank ID NC_000002
XM_011511705
XP_011510007
NM_001243835
NP_001230764
NM_003151
NP_003142
XM_006712719
XP_006712782
XM_017004784
XP_016860273
NG_012852
AB111353
AC067945
AAY24184
AC079777
AAY15055
AF423072
AAL12164
AX354560
CAD22977
CH471058
EAX10846
EAX10847
EAX10848
EAX10849
DQ003482
KT584956
AB209043
BAD92280
AK299976
BAG61799
AK300868
BAG62516
AK301172
BAG62759
BC016694
BC031212
AAH31212
BF966132
DC306142
DC399230
EU304788
ACA01857
EU304789
ACA01858
EU304790
ACA01859
EU304791
ACA01860
EU304792
ACA01861
EU304793
ACA01862
L78440
AAB05605
MF781077
ATE87180
Q14765
NC_000067
XM_006495815
XP_006495878
XM_006495814
XP_006495877
NM_001308266
NP_001295195
XM_006495816
XP_006495879
NM_011487
NP_035617
AC108840
AC123752
CH466548
EDK99962
EDK99963
AK037598
AK088991
BAC40690
AK132675
BAE21295
AK157083
BAE33957
BC052907
BC098499
AAH98499
BF020635
BY097735
BY750146
U06923
AAA19453
U09351
AAA19692
P42228
NC_005108
NM_001012226
NP_001012226
AC_000077
AABR07067608
AABR07067609
AABR07067610
AAHX01059849
AAHX01059850
AF055291
AAC12758
BC081938
AAH81938
XM_011511704
XP_011510006
XM_005246817
XP_005246874
XM_011511706
XP_011510008
NC_018913
AC092614
AMYH02005442
AMYH02005443
HG495061
DQ891548
ABM82474
DQ894736
ABM85662
AC_000023
AAHY01006299
AAHY01006300
AAHY01006301
AAHY01006302
AAHY01006303
AAHY01006304
AAHY01006305
AAHY01006306
AC_000134
ABBA01062392
ABBA01062393
ABBA01062394
ABBA01062395
NT_005403
NW_921585
NW_001838863
AC_000045
Q53RU2
Q53S87
Q59GR6
NT_039170
NW_001030680
Q3U098
Q3V157
Q4G0C1
Q8C2A4
NW_047815
NW_001084882
O70428
Q66HB2

Swiss-Prot ID STAT4_HUMAN
STAT4_MOUSE
Q66HB2_RAT
Q3V157_MOUSE

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000138378
ENSP00000351255.4
ENST00000358470.8
ENSP00000376134.2
ENST00000392320.7
ENSMUSG00000062939
ENSMUSP00000130713.1
ENSMUST00000168302.7
ENSMUSP00000027277.5
ENSMUST00000027277.6
ENSRNOG00000014079
ENSRNOP00000020032.5
ENSRNOT00000020032.6
ENST00000392320.6
ENSP00000351255
ENST00000358470
ENSP00000376134
ENST00000392320
ENSMUSP00000027277
ENSMUST00000027277
ENSRNOP00000020032
ENSRNOT00000020032
ENSMUSP00000130713
ENSMUST00000168302
ENSRNOG00000050942

MGI ID MGI:103062
103062

RGD ID 1305747

Unigene ID Hs.80642
Mm.1550
Rn.137580
Hs.735572

Homologene ID 20679

Shape O-vertex

IPI ID IPI00114970
IPI00000106
IPI00471606
IPI00649102