Pathway
|
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
|
|
PRL and CSH Action in Mammary Gland
|
|
Thrombopoietin Receptors Signaling in Platelet Maturation
|
|
Natural Killer Cell Activation
|
|
CD8+ T-Cell Activation
|
|
T-Cell Cytotoxic Mediated Cell Death
|
|
Th1-Cell Differentiation
|
|
AHR Signaling in Treg and Dendritic Cells Function
|
|
AHR Signaling in Tr1 Cells Function
|
|
CXC Chemokine Receptor Signaling
|
|
CC Chemokine Receptor Signaling
|
|
Plasmin Effects in Inflammation
|
|
Basophil Activation
|
|
Eosinophil Survival by Cytokine Signaling
|
|
Mast-Cell Activation via IgE Signaling
|
|
Mast-Cell Activation without Degranulation through CXCR4 Signaling
|
|
Mast-Cell Activation without Degranulation
|
|
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
|
|
Macrophage M1 Lineage
|
|
CD16/CD14 Proinflammatory Monocyte Activation
|
|
AHR Signaling in M1 Macrophages Function
|
|
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
|
|
Neutrophil Recruitment and Priming
|
|
Vascular Endothelial Cell Activation by Cytokines
|
|
Vascular Endothelial Cell Activation by Blood Coagulation Factors
|
|
Vascular Endothelial Cell Activation by Growth Factors
|
|
Nociception Expression Targets Signaling
|
|
CCR1 Expression Targets
|
|
IL6 Expression Targets -> Nociception
|
|
G0/G1 Phase Transition
|
|
Proteins Involved in Atherosclerosis
|
|
Th1-Cells Activation and Proliferation in Atherosclerosis
|
|
Cardiomyocyte Hypertrophy
|
|
Hypertrophic Cardiomyopathy
|
|
Endothelial Cell Dysfunction in Pulmonary Hypertension
|
|
Proteins Involved in Myocardial Ischemia
|
|
Preconditioning Ischemia
|
|
Lymphocyte Mediated Myocardial Injury in Myocarditis
|
|
SOCS in Negative Feedback Regulation in Myocarditis
|
|
Hair Follicle Keratinocyte Apoptosis
|
|
Atopic Dermatitis
|
|
Melanoma
|
|
Apoptosis Block in Melanoma Cell
|
|
Proteins Involved in Melanoma
|
|
T-Cells Differentiation Block in Psoriasis
|
|
IFN-gamma/TNF-alpha Mediated Cell Proliferation in Psoriasis
|
|
Dendritic Cell Activation in Systemic Lupus Erythematosis
|
|
Proteins Involved in Systemic Lupus Erythematosus
|
|
Th1-Cell Function in Systemic Lupus Erythematosus
|
|
B-Cell Activation in Systemic Lupus Erythematosus
|
|
Vitiligo
|
|
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
|
|
Plasmacytoid Dendritic Cell in Diabetes Mellitus Type 1
|
|
Toll-like Receptors in beta-Cell
|
|
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
|
|
Proteins Involved in Diabetic Nephropathy
|
|
beta-Cell Destruction through Cytokines in Diabetes Mellitus
|
|
beta-Cell Destruction in Diabetes Mellitus Type 1
|
|
Nitric Oxide Effects on beta-Cell
|
|
Hashimoto's Thyroiditis
|
|
Proteins Involved in Hypothyroidism
|
|
Proteins Involved in Celiac Disease
|
|
CD4+T-Cell Response in Celiac Disease
|
|
Metastatic Colorectal Cancer
|
|
Th1-Cell Activation in Crohn's Disease
|
|
OipA Signaling in Helicobacter Pylori Infection
|
|
Proteins Involved in Ulcerative Colitis
|
|
B-Cell Acute Lymphoblastic Leukemia
|
|
Diffuse Large-B-Cell Lymphoma
|
|
Primary Mediastinal B-cell Lymphoma (PMBL) Subtype
|
|
Follicular Lymphoma
|
|
Proteins Involved in Hodgkin Lymphoma
|
|
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
|
|
Multiple Myeloma
|
|
T-Cell Acute Lymphoblastic Leukemia
|
|
Eosinophil Survival in Asthma
|
|
Mast-Cell Activation in Asthma
|
|
Osteoclast Activation in Gout
|
|
Neutrophil Recruitment in Sinovium in Gout
|
|
Dendritic Cell Dysfunction in Psoriatic Arthritis
|
|
Osteoclast Activation in Psoriatic Arthritis
|
|
Keratinocyte Activation in Psoriatic Arthritis
|
|
Proteins Involved in Psoriatic Arthritis
|
|
Osteoclast Activation in Rheumatoid Arthritis
|
|
Skin Fibrosis
|
|
CCR5 Signaling in Macrophages
|
|
CD4+ T-Cell Death in HIV
|
|
Diabetes Induced Periodontitis
|
|
Glioblastoma, Primary
|
|
Glioblastoma, Secondary
|
|
Astrocytoma
|
|
IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis
|
|
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
|
|
Proteins Involved in Breast Cancer Related to IGF1R/Akt Signaling Pathway
|
|
Cholesteatoma
|
|
Prostate Cancer
|
|
RNase L Signaling in Prostate Cancer
|
|
Proteins Involved in Prostate Cancer
|
|
CDKN2B-AS1 in Epigenetic Regulation of Glaucoma
|
|
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model)
|
|
Proteins Involved in Hearing Loss
|
|
Cytokines Trigger Otitis Media
|
|
Proteins Involved in Chronic Obstructive Pulmonary Disease
|
|
Polycystins Mutation Effects in Cystic Kidney Disease
|
|
Endothelial Cell Dysfunction in Pyelonephritis
|
|
AREG -> STAT Expression Targets
|
|
Noreadrenaline/Gq Expression Targets
|
|
Epinephrine/Gq Expression Targets
|
|
Aryl Hydrocarbon Receptor Genomic and non-Genomic Signaling
|
|
BTC -> STAT Expression Targets
|
|
IFNG -> ARRB1/STAT1 Signaling
|
|
CD2 Expression Targets
|
|
CD22 -> STAT Expression Targets
|
|
CD8 -> NFATC Expression Targets
|
|
CD80 -> ATF/CREB/CREBBP Expression Targets
|
|
CD86 -> ATF/CREB/CREBBP Expression Targets
|
|
CXCL12 Expression Targets
|
|
CCL3 Expression Targets
|
|
CCL16 Expression Targets
|
|
CCL5 Expression Targets
|
|
CCL7 Expression Target
|
|
CCL15 Expression Targets
|
|
CCL2 Expression Targets
|
|
IL8 Expression Targets
|
|
CSF3 Expression Targets
|
|
CSF2 -> STAT Expression Targets
|
|
Clozapine Induced Granulocytopenia
|
|
EGF -> STAT Expression Targets
|
|
EGFR/ERBB -> STAT Signaling
|
|
EREG -> STAT Expression Targets
|
|
Erythropoietin -> STAT Expression Targets
|
|
F2 -> STAT1/NF-kB Expression Targets
|
|
PLG -> STAT1/NF-kB Expression Targets
|
|
FGF2 -> STAT Expression Targets
|
|
FGF10 -> STAT Expression Targets
|
|
FGF18 -> STAT Expression Targets
|
|
FGF1 -> STAT Expression Targets
|
|
FGFR1 -> STAT Signaling
|
|
FGFR3 -> STAT Signaling
|
|
GH1/GHR -> STAT Expression Targets
|
|
CSH1/GHR Expression Targets
|
|
CSH1/PRLR Expression Targets
|
|
GH1/PRLR Expression Targets
|
|
HGF -> STAT Expression Targets
|
|
HGFR -> STAT Signaling
|
|
Receptors and Adaptor Proteins Activated in Cancer
|
|
Proteins with Altered Expression in Cancer-Associated Sustaining of Proliferative Signaling
|
|
G0/G1 Cell Cycle Phase Transition Activation in Cancer
|
|
N2 Neutrophils in Tumor-Promoting Inflammation and Tumor Progression
|
|
VEGF Independent Angiogenesis in Cancer
|
|
Myeloid Derived Suppressor Cells in Cancer Immune Escape
|
|
IDO1 in Cancer Immune Escape
|
|
IGF2 -> STAT Expression Targets
|
|
IGF1 -> STAT Expression Targets
|
|
Insulin -> STAT Expression Targets
|
|
CD2 -> STAT Signaling
|
|
InsulinR -> STAT Signaling
|
|
IGF1R -> STAT Signaling
|
|
IFNLR1-> STAT/NFKB Signaling
|
|
IFNW1/IFNR Expression Target
|
|
IFNA1/IFNR Expression Targets
|
|
IFNB1/IFNR Expression Targets
|
|
IFNG/IFNR Expression Targets
|
|
IL31R -> STAT Signaling
|
|
IL15R -> STAT Signaling
|
|
IL10R -> STAT Signaling
|
|
IL13R -> STAT Signaling
|
|
IL3R -> STAT Signaling
|
|
IL27R -> STAT Signaling
|
|
IL7R -> STAT Signaling
|
|
IL9R -> STAT Signaling
|
|
IL5R -> STAT Signaling
|
|
IL6R -> STAT Signaling
|
|
IL2R -> STAT Signaling
|
|
IL12R -> STAT Signaling
|
|
IL21R -> STAT Signaling
|
|
IL7 Expression Targets
|
|
IL13 Expression Targets
|
|
IL21 Expression Targets
|
|
IL15 Expression Targets
|
|
IL12B Expression Targets
|
|
IL3 Expression Targets
|
|
IL6 Expression Targets
|
|
IL10 Expression Targets
|
|
IL5 Expression Targets
|
|
IL9 Expression Targets
|
|
IL31 Expression Targets
|
|
IL2 Expression Targets
|
|
UrokinaseR -> STAT Signaling
|
|
Leptin -> STAT Expression Targets
|
|
EGFR-> Expression Targets in Lymphoid System and Blood
|
|
NRG1 -> STAT Expression Targets
|
|
PTGER4 -> Expression Targets in Nerve Tissue
|
|
PDGF -> STAT Expression Targets
|
|
PDGFR -> STAT Signaling
|
|
CSF2 -> STAT Signaling
|
|
KIT -> STAT Signaling
|
|
GAST Expression Targets in GAST Expression Targets
|
|
CCL11 Expression Targets
|
|
AVP/Gq -> STAT Expression Targets
|
|
AVP/Gs -> STAT Expression Targets
|
|
AGT -> STAT Expression Targets
|
|
PRL/PRLR Expression Targets
|
|
PRL/GHR -> STAT Expression Targets
|
|
ProlactinR -> STAT Signaling
|
|
PDCD1 -> STAT Expression Targets
|
|
ALK -> STAT Signaling
|
|
EphrinR -> STAT Signaling
|
|
CSF1 -> STAT Expression Targets
|
|
MDK/PTN Expression Targets
|
|
KITLG -> STAT Expression Targets
|
|
EphrinR Expression Targets
|
|
Ras-GAP Regulation Signaling
|
|
AXL Receptor Tyrosine Kinase Signaling
|
|
EGFR Signaling
|
|
TCR -> STAT Expression Targets
|
|
T-Cell Receptor -> STAT Signaling
|
|
TGFA -> STAT Expression Targets
|
|
LTA Expression Targets
|
|
TNF -> STAT Expression Targets
|
|
TNFRSF1A -> STAT Signaling
|
|
Thrombopoietin -> STAT Expression Targets
|
|
PLAU -> STAT1 Expression Targets
|
|
VEGFA -> STAT Expression Targets
|
|
VEGFR -> STAT Signaling
|
|
PPAR Psoriasis
|
|
pprarg neg, uknown targets, ps-positive
|
|
prarg neg,ukn expres targets, ps-positive
|
|
PPARG negative targets
|
|
pparg expr target_regulators
|
|
Neighbors of disease exacerbation
|
|
Neighbors of tumor progression
|
|
Neighbors of cancer progression
|
|
Neighbors of inflammatory status
|
|
Neighbors of overall survival
|
|
Neighbors of disease severity
|
|
Neighbors of tumor size
|
|
Neighbors of lesion size
|
|
Neighbors of mortality
|
|
Neighbors of infarct size
|
|
Neighbors of functional recovery
|
|
Neighbors of bacterial load
|
|
Neighbors of cancer survival
|
|
Neighbors of graft survival
|
|
Neighbors of lethality
|
|
Neighbors of tumor regression
|
|
Neighbors of disease-free survival
|
|
Neighbors of tumor response
|
|
Neighbors of macrophage count
|
|
Neighbors of bone mass
|
|
Neighbors of tumor recurrence
|
|
Neighbors of tumor promotion
|
|
Neighbors of morbidity
|
|
Neighbors of fibrosis progression
|
|
Neighbors of bone mineral density
|
|
Neighbors of radioresistance
|
|
Neighbors of lesion area
|
|
Neighbors of cell density
|
|
Neighbors of early mortality
|
|
Neighbors of viral load
|
|
Neighbors of leukocyte count
|
|
Neighbors of cancer risk
|
|
Neighbors of tumor aggressiveness
|
|
Neighbors of tumor resistance
|
|
Neighbors of osteoclast number
|
|
Neighbors of cancer recurrence
|
|
Neighbors of T-cell count
|
|
Neighbors of radiosensitivity
|
|
Neighbors of recurrence rate
|
|
Neighbors of disease exacerbation
|
|
Neighbors of tumor progression
|
|
Neighbors of cancer progression
|
|
Neighbors of inflammatory status
|
|
Neighbors of overall survival
|
|
Neighbors of disease severity
|
|
Neighbors of tumor size
|
|
Neighbors of lesion size
|
|
Neighbors of mortality
|
|
Neighbors of infarct size
|
|
Neighbors of functional recovery
|
|
Neighbors of bacterial load
|
|
Neighbors of cancer survival
|
|
Neighbors of graft survival
|
|
Neighbors of lethality
|
|
Neighbors of tumor regression
|
|
Neighbors of disease-free survival
|
|
Neighbors of tumor response
|
|
Neighbors of macrophage count
|
|
Neighbors of bone mass
|
|
Neighbors of tumor recurrence
|
|
Neighbors of tumor promotion
|
|
Neighbors of morbidity
|
|
Neighbors of fibrosis progression
|
|
Neighbors of bone mineral density
|
|
Neighbors of radioresistance
|
|
Neighbors of lesion area
|
|
Neighbors of cell density
|
|
Neighbors of early mortality
|
|
Neighbors of viral load
|
|
Neighbors of leukocyte count
|
|
Neighbors of cancer risk
|
|
Neighbors of tumor aggressiveness
|
|
Neighbors of tumor resistance
|
|
Neighbors of osteoclast number
|
|
Neighbors of cancer recurrence
|
|
Neighbors of T-cell count
|
|
Neighbors of radiosensitivity
|
|
Neighbors of recurrence rate
|
|
Neighbors of cell development
|
|
Neighbors of immune response
|
|
Neighbors of cell population
|
|
Neighbors of T-cell development
|
|
Neighbors of inflammatory response
|
|
Neighbors of wound healing
|
|
Neighbors of angiogenesis
|
|
Neighbors of innate immune response
|
|
Neighbors of cell function
|
|
Neighbors of macrophage activation
|
|
Neighbors of cell formation
|
|
Neighbors of adaptive immune response
|
|
Neighbors of osteoclast development
|
|
Neighbors of epithelial to mesenchymal transition
|
|
Neighbors of immunity
|
|
Neighbors of cell proliferative response
|
|
Neighbors of chemotaxis
|
|
Neighbors of dendritic cell differentiation
|
|
Neighbors of cell survival
|
|
Neighbors of osteoclast differentiation
|
|
Neighbors of cell phenotype
|
|
Neighbors of T-cell proliferation
|
|
Neighbors of tissue remodeling
|
|
Neighbors of cell adhesion
|
|
Neighbors of T-cell activation
|
|
Neighbors of endothelial cell proliferation
|
|
Neighbors of tumor growth
|
|
Neighbors of dendritic cell development
|
|
Neighbors of tissue repair
|
|
Neighbors of cell count
|
|
Neighbors of cell infiltration
|
|
Neighbors of cell interaction
|
|
Neighbors of SMC proliferation
|
|
Neighbors of lumen formation
|
|
Neighbors of endothelial cell migration
|
|
Neighbors of adipogenesis
|
|
Neighbors of lipid storage
|
|
Neighbors of cell damage
|
|
Neighbors of pregnancy
|
|
Neighbors of monocyte differentiation
|
|
Neighbors of aging
|
|
Neighbors of cell motility
|
|
Neighbors of bone resorption
|
|
Neighbors of monocyte migration
|
|
Neighbors of fibroblast proliferation
|
|
Neighbors of adipocyte differentiation
|
|
Neighbors of macrophage migration
|
|
Neighbors of microglial activation
|
|
Neighbors of cell migration
|
|
Neighbors of cancer growth
|
|
Neighbors of stem cell proliferation
|
|
Neighbors of smooth muscle cell migration
|
|
Neighbors of hepatic regeneration
|
|
Neighbors of transendothelial migration
|
|
Neighbors of phagocytosis
|
|
Neighbors of immune system activation
|
|
Neighbors of leukocyte migration
|
|
Neighbors of osteoclast formation
|
|
Neighbors of cell invasion
|
|
Neighbors of hemopoiesis
|
|
Neighbors of bone remodeling
|
|
Neighbors of ossification
|
|
Neighbors of T-cell function
|
|
Neighbors of immune system function
|
|
Neighbors of autophagy
|
|
Neighbors of monocyte adhesion
|
|
Neighbors of transcription activation
|
|
Neighbors of senescence
|
|
Neighbors of T-cell response
|
|
Neighbors of tumor immunity
|
|
Neighbors of hepatocyte proliferation
|
|
Neighbors of cell transdifferentiation
|
|
Neighbors of neuronal death
|
|
Neighbors of cell growth
|
|
Neighbors of ROS generation
|
|
Neighbors of epithelial cell proliferation
|
|
Neighbors of cancer cell growth
|
|
Neighbors of sensitization
|
|
Neighbors of hemato-encephalic barrier
|
|
Neighbors of macrophage function
|
|
Neighbors of cellular immune response
|
|
Neighbors of cellular senescence
|
|
Neighbors of colony formation
|
|
Neighbors of macrophage differentiation
|
|
Neighbors of cell differentiation
|
|
Neighbors of cell homeostasis
|
|
Neighbors of psoriasis
|
|
Neighbors of inflammatory disease
|
|
Neighbors of rheumatoid arthritis
|
|
Neighbors of atherosclerosis
|
|
Neighbors of fibrosis
|
|
Neighbors of colitis
|
|
Neighbors of arthritis
|
|
Neighbors of inflammatory bowel disease
|
|
Neighbors of injury
|
|
Neighbors of metastasis
|
|
Neighbors of carcinogenesis
|
|
Neighbors of multiple sclerosis
|
|
Neighbors of chronic inflammation
|
|
Neighbors of inflammation
|
|
Neighbors of tumor microenvironment
|
|
Neighbors of obesity
|
|
Neighbors of diabetes mellitus
|
|
Neighbors of asthma
|
|
Neighbors of pneumonia
|
|
Neighbors of liver fibrosis
|
|
Neighbors of chronic obstructive pulmonary disease
|
|
Neighbors of myocardial infarction
|
|
Neighbors of leukocyte infiltration
|
|
Neighbors of reperfusion injury
|
|
Neighbors of airway inflammation
|
|
Neighbors of hepatitis
|
|
Neighbors of insulin resistance
|
|
Neighbors of infection
|
|
Neighbors of vascular injury
|
|
Neighbors of renal injury
|
|
Neighbors of macrophage infiltration
|
|
Neighbors of liver injury
|
|
Neighbors of neuroinflammation
|
|
Neighbors of sepsis
|
|
Neighbors of death
|
|
Neighbors of type 1 diabetes
|
|
Neighbors of encephalomyelitis
|
|
Neighbors of autoimmune disease
|
|
Neighbors of ischemic stroke
|
|
Neighbors of dermatitis
|
|
Neighbors of neutrophil infiltration
|
|
Neighbors of diabetic nephropathy
|
|
Neighbors of lung injury
|
|
Neighbors of immunopathology
|
|
Neighbors of systemic sclerosis
|
|
Neighbors of hepatocellular carcinoma
|
|
Neighbors of autoimmunity
|
|
Neighbors of acute lung injury
|
|
Neighbors of gastric cancer
|
|
Neighbors of experimental autoimmune encephalomyelitis
|
|
Neighbors of colorectal cancer
|
|
Neighbors of cardiac remodeling
|
|
Neighbors of breast cancer
|
|
Neighbors of ischemia
|
|
Neighbors of systemic lupus erythematosus
|
|
Neighbors of melanoma
|
|
Neighbors of collagen-induced arthritis
|
|
Neighbors of interstitial fibrosis
|
|
Neighbors of kidney disease
|
|
Neighbors of heart failure
|
|
Neighbors of lung disease
|
|
Neighbors of pulmonary fibrosis
|
|
Neighbors of cardiovascular disease
|
|
Neighbors of stroke
|
|
Neighbors of cancer
|
|
Neighbors of neoplasm
|
|
Neighbors of neointima
|
|
Neighbors of vasculitis
|
|
Neighbors of atrophy
|
|
Neighbors of respiratory hypersensitivity
|
|
Neighbors of myocardial fibrosis
|
|
Neighbors of synovitis
|
|
Neighbors of coronary artery disease
|
|
Neighbors of liver disease
|
|
Neighbors of prostate cancer
|
|
Neighbors of ovarian cancer
|
|
Neighbors of pancreatic cancer
|
|
Neighbors of hypertension
|
|
Neighbors of allograft rejection
|
|
Neighbors of macrophage
|
|
Neighbors of fibroblast
|
|
Neighbors of hepatocyte
|
|
Neighbors of endothelial cell
|
|
Neighbors of immunocompetent cell
|
|
Neighbors of myeloid cell
|
|
Neighbors of insulin-secreting cell
|
|
Neighbors of T-cell
|
|
Neighbors of lung
|
|
Neighbors of colorectal region
|
|
Neighbors of NF-kB family
|
|
Neighbors of Jun/Fos
|
|
Neighbors of NFKBI
|
|
Neighbors of STAT family
|
|
Neighbors of IFNAR ligand
|
|
Neighbors of cytokine
|
|
Neighbors of interferon
|
|
Neighbors of JAK
|
|
Neighbors of Ras GTPase
|
|
Neighbors of ovalbumin
|
|
Neighbors of LXR
|
|
Neighbors of lectin
|
|
Neighbors of proteasome endopeptidase complex
|
|
Neighbors of STAT5
|
|
Neighbors of retinoid-X receptor subfamily
|
|
Neighbors of ITG
|
|
Neighbors of TORC1
|
|
Neighbors of RA receptor
|
|
Neighbors of histone acetyltransferase
|
|
Neighbors of deacetylase
|
|
comon ps_pos, pprarg_neg targets
|
|
Model of PPARG signaling in psoriasis
|
|
PPARG negative regulators and targets
|
|
Model of PPARG related pathways in psoriasis (short version)
|
|
New Pathway (3)
|
|
sars-cov no binding
|
|
IFN signaling in alveolar cells
|
|
Dendritic Cell Activation in COVID19
|
|
Figure 3_Mixed network of dexamethasone targets
|
|
Figure 3_Mixed network of dexamethasone targets
|
|
1_Differentiation of psoriatic T cells
|
|
1_Formation of cysts in polycystic kidney disease
|
|
1_Endothelial cells stimulate vasoconstriction and thrombosis in pulmonary hypertension
|
|
2_Cardiomyocyte hypertrophy
|
|
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
|
|
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
|
|
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
|
|
3_Islet beta-cell destruction in T1D
|
|
drug-target pairs direct regulation
|
|
drug-target moltransport
|
|
Differentiation of psoriatic T cells
|