Protein NOD1

URN urn:agi-llid:10392
Total Entities 0
Connectivity 1213
Name NOD1
Description nucleotide binding oligomerization domain containing 1
Notes This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

Pathway NOD-like Receptors
Proteins Involved in Acne Vulgaris
Genes with Mutations Associated with Atopic Dermatitis
Proteins Involved in Helicobacter Infections
CagA Phosphorylation Independent Signaling
Dendritic Cell Function in Ulcerative Colitis
Proteins Involved in Periodontitis
Blau Syndrome
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
Overview. Diseases of the skin (chapter 11)
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
1_Th2 cell response in asthma
2_Paneth cell dysfunction in Crohn's disease
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
4_1_Polymorphisms associated with inflammatory bowel diseases

Group Genes with Mutations Associated with Atopic Dermatitis

MedScan ID 10392

LocusLink ID 10392
107607
500133

Alias nucleotide oligomerization domain protein 1
caspase recruitment domain-containing protein 4
Nod1
nucleotide-binding oligomerization domain containing 1
NOD1 signaling adaptor protein
F830007N14Rik
nucleotide binding oligomerization domain protein 1
F830007N14
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1
NLRC1
Nod I
RGD1562269
NLR family, CARD domain containing 1
caspase recruitment domain 4
RIKEN cDNA F830007N14 gene
Card4
caspase recruitment domain family, member IV
C230079P11
CLR7.1
caspase recruitment domain family, member 4
nucleotide-binding oligomerization domain-containing protein 1

GO ID 0005524
0050700
0008656
0042834
0042803
0044877
0007254
0000187
0006919
0006915
0071225
0006952
0050830
0042742
0016045
0009595
0006954
0045087
0070498
0042228
0035556
0070423
0070374
0043123
0046330
0051092
1901224
0043280
0002606
0032731
0032755
0051000
0032760
1904417
0051259
0007165
0016324
0016323
0005737
0005829
0000166
0002376
0010942
0032874
0042981
0016020
0005886
0002755
0002756
0035666
0035872
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0008063
0006917
0034130
0005622

KEGG ID hsa:10392
mmu:107607
rno:500133

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 6

OMIM ID 605980

Rat chromosome position 4q24

Hugo ID 16390
HGNC:16390

Human chromosome position 7p14.3
7p15-p14

Swiss-Prot Accession A0A024RA73
Q9Y239
G3XAL1
Q9Y239.1
Q540J8
Q8BHB0
Q8BHB0.1
D4ADT7
B4DTU3
Q549U4
Q8IWF5
Q8BUT6

GenBank ID NC_000007
NR_149002
XR_002956406
XR_926908
XR_001744529
XR_926909
XR_926910
XR_001744530
NM_001354849
NP_001341778
XM_011515081
XP_011513383
XM_005249572
XP_005249629
NM_006092
NP_006083
XM_011515079
XP_011513381
XM_011515083
XP_011513385
XM_011515085
XP_011513387
XM_011515084
XP_011513386
XM_005249568
XP_005249625
XM_006715633
XP_006715696
XM_011515080
XP_011513382
XM_005249576
XP_005249633
XM_017011674
XP_016867163
XM_011515087
XP_011513389
XM_011515088
XP_011513390
NG_013025
AACC02000087
EAL24453
AC005154
AC006027
AAS46897
AH007965
AX082205
CAC33156
CH471073
EAW93944
EAW93945
EAW93946
EAW93947
EAW93948
EAW93949
AA845215
AF113925
AAD28350
AF126484
AAD29125
AK023969
BAG51242
AK300367
BAG62105
AY128682
AAM98064
AY128683
AAM98065
AY128684
AAM98066
AY128685
AAM98067
AY128686
AAM98068
AY187249
AY187250
BC020114
BC040339
AAH40339
CV569884
KU178514
ALQ33972
KU178515
ALQ33973
KU178516
ALQ33974
KU178517
ALQ33975
Q9Y239
NC_000072
NM_172729
NP_766317
NM_001171007
NP_001164478
XM_006505278
XP_006505341
XR_377400
AC079183
CH466597
EDK98713
AI645572
AK082663
BAC38566
AK089662
BAC40940
AK137585
BAE23420
AY160222
AAN52479
BC043670
AAH43670
Q8BHB0
NC_005103
NM_001109236
NP_001102706
XM_008762910
XP_008761132
AC_000072
AABR07060610
AAHX01030269
AAHX01030270
CH474011
EDL88106
XM_011515086
XP_011513388
XM_011515082
XP_011513384
XR_926907
NC_018918
AF149773
AF149774
AAD43922
AMYH02015456
AMYH02015457
AMYH02015458
AMYH02015459
AMYH02015460
XM_006505277
XP_006505340
AC_000028
NW_001073834
AAHY01053426
AAHY01053427
AAHY01053428
AAHY01146467
BC042670
AAH42670
XM_006715635
XP_006715698
XM_005249575
XP_005249632
XM_005249574
XP_005249631
XM_005249573
XP_005249630
XM_006715634
XP_006715697
XR_428069
XM_006715636
XP_006715699
XM_006715637
XP_006715700
AC_000139
ABBA01056813
AC_000068

Swiss-Prot ID NOD1_HUMAN
NOD1_MOUSE

Cell Localization Cytoplasm
Cell membrane
Apical cell membrane
Basolateral cell membrane

Ensembl ID ENSG00000106100
ENSP00000222823.4
ENST00000222823.9
ENSP00000416946.1
ENST00000434755.5
ENSMUSG00000038058
ENSMUSP00000130487.1
ENSMUST00000168172.3
ENSMUSP00000055747.8
ENSMUST00000060655.14
ENSRNOG00000010629
ENSRNOP00000014324.4
ENSRNOT00000014324.6
ENSP00000222823
ENST00000222823
ENSP00000416946
ENST00000434755
ENSMUSP00000130487
ENSMUST00000168172
ENSMUSP00000055747
ENSMUST00000060655
ENSRNOP00000014324
ENSRNOT00000014324

MGI ID MGI:1341839
1341839

RGD ID 1562269

Unigene ID Hs.405153
Hs.738731
Mm.28498
Rn.53929

Homologene ID 4440

IPI ID IPI00005776
IPI00221820