Protein MAPK14

URN urn:agi-llid:1432
Total Entities 0
Connectivity 16208
Name MAPK14
Description mitogen-activated protein kinase 14
Notes The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase
ObjectType Protein

Pathway Alzheimer's Disease
Osteoarthritis
Skin Aging
Oncogene Induced Cellular Senescence
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thrombopoietin Receptors Signaling in Platelet Maturation
T-Cell Dependent B-Cell Activation
T-Cell Maturation (Hypothesis)
T-Cell Positive Selection and Neglect Induced Death
T-Cell Central Tolerance
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
AHR Signaling in Tr1 Cells Function
Platelet Activation via Adhesion Molecules
Scavenger Receptors in Platelet Activation
Bradykinin Effects in Inflammation
MC1R in anti-Inflammatory Signaling
Leukotriene Effect on Vascular Endothelial Cell Response
Leukotriene Effect on Airway Smooth Muscle Response
Basophil Activation
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation
Mast-Cell Activation without Degranulation through IL33/IL1RL1 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Macrophage M1 Lineage
Neutrophil Recruitment and Priming
Neutrophil Degranulation via FPR1 Signaling
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Cytokines
Vascular Endothelial Cell Activation by Growth Factors
GFs/TNF -> Ion Channels
Nociception Expression Targets Signaling
EDNRA/B -> Vascular Motility
ADRA1A -> IL6 Production
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
CHRM1 -> IL2 Production
HTR1 -> IL6 Production
HTR5 -> TNF Production
HTR1 -> Membrane Transport
IL1B Expression Targets -> Nociception
Luteinizing Hormone in Oocyte Meiotic Resumption
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Cardiomyocyte Dysfunction
Proteins Involved in Atherosclerosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Dendritic Cells Function in Atherosclerosis
Th1-Cells Activation and Proliferation in Atherosclerosis
Dilated Cardiomyopathy
Proteins Involved in Hypertrophic Cardiomyopathy
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Proteins Involved in Arterial Hypertension
Proteins Involved in Pulmonary Hypertension
Proteins Involved in Myocardial Ischemia
Proteins Involved in Myocarditis
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Acute Phase in Atopic Dermatitis
Atopic Dermatitis
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Proteins with Altered Expression in Psoriasis
Dendritic Cells Function in Psoriasis
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Humoral Immunity in Vitiligo
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Treg-Cell Activation in Diabetes Mellitus
Proteins Involved in Diabetes Mellitus Type 2
Podocyte Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Proteins Involved in Diabetic Neuropathy
Adiponectin in Insulin Resistance Prevention
Proteins Involved in Insulin Resistance
Insulin Resistance in Hepatocytes
Oxidation of Fatty Acid in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
Nitric Oxide Effects on beta-Cell
Immune Sustem Activation in Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
Bone Remodeling in Hyperthyroidism
CD4+T-Cell Response in Celiac Disease
Celiac Disease
OipA Signaling in Helicobacter Pylori Infection
Epithelial Cell in the Innate Immune Response in Ulcerative Colitis
Th2-Cell Function in Ulcerative Colitis
Antiphospholipid Antibodies in Platelets and Coagulation Cascade
Antiphospholipid Antibodies in Endothelial Cell
Proteins Involved in Antiphospholipid Syndrome
Proteins Involved in B-Cell Chronic Lymphocytic Leukemia
Osteoclast Activation in Multiple Myeloma
Proteins Involved in Multiple Myeloma
Antiphospholipid Antibodies and Endothelial Cell Interaction
Platelet and Coagulation Cascade Activation by Antiphospholipid Antibodies
IL33 Signaling Related Eosinophilia in Asthma
IgE Induces Airway Smooth Muscle Cell Proliferation
Basophil Activation in Asthma
Mast-Cell Activation in Asthma
Th2-Cell Response in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
CFTR Expression in Epithelial Cells (Class I Mutations)
Osteoblast Function Decline in Gout
Osteoclast Activation in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
Apoptosis of Chondrocyte
IL1B Induced Arthralgia
TGFB2 Signaling Impairement in Osteoarthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
Apoptosis Block in Synovial Fibroblast
Proteins Involved in Rheumatoid Arthritis
Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
CCR5 Signaling in Macrophages
Apoptosis Block in Infected Cells
Diabetes Induced Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
Cryopyrin (NLPR3) Associated Periodic Syndromes
Bone Loss in Osteoporosis
Hyperparathyroidism, Secondary Effect
Osteoclast Activation in Postmenopause
Proteins Involved in Alzheimer's Disease
Glioma Invasion Signaling
Prostaglandin E2 Synthesis Activation via Glutamate in Familial Hemiplegic Migraine
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
Proteins Involved in Amyotrophic Lateral Sclerosis
Microglia and Motor Neuron Interaction Dysregulation
Crystallin alpha B (CRYAB) Suppresses Multiple Sclerosis
Breast Cancer
Proteins Involved in Endometriosis
Angiogenesis in Endometriosis
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
Neurotrophic Factor Deprivation in Retinal Ganglion Cell Death
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Proteins Involved in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Podocyte Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Interstitial Fibroblasts in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> NFATC Expression Target
AREG -> CREB/CREBBP Expression Targets
AREG -> AP-1 Expression Targets
Acetylcholine Expression Targets
Dopamine/Gi Expression Targets
BTC -> NFATC Expression Targets
BTC -> AP-1/ATF/CREB Expression Targets
CXCR4 -> ARRB1 Signaling
Sialophorin -> CTNNB/MYC/TP53 Signaling
CD72 -> NF-kB Expression Targets
CD8 -> NF-kB Expression Targets
CD80 -> NFATC Expression Targets
CD86 -> NFATC Expression Targets
CCL3 Expression Targets
CCL7 Expression Target
IL8 Expression Targets
Complement Component GPCRs Signaling
Doxorubicin Induced Cardiotoxicity
Clozapine Induced Granulocytopenia
Cyclosporine Induced Nephrotoxicity
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG Signaling
EGFR/ERBB2 -> TP53 Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
ADCYAP1 Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> MEF/MYOD Expression Target
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
Oxidized LDL/OLR1 Activates Cell Proliferation in Cancer
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF2/MEF/MYOD Expression Targets
Insulin -> MEF/MYOD Expression Targets
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> MEF/MYOD/MYOG Signaling
FibronectinR -> NF-kB Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
IL1R -> NF-kB Signaling
IL16-> ATF/CREB/CREBBP Expression Target
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
NRG1 -> MEF/MYOD Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
AGT -> TP53 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
AGT -> ELK/SRF Expression Targets
AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PDCD1 -> ATF/CREB/CREBBP Expression Targets
DDR1 -> NF-kB Signaling
AngiopoietinR -> AP-1 Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
Collagen -> NF-kB Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
TGFBR -> AP-1 Signaling
TGFBR -> CREB/ELK-SRF Signaling
TGFBR -> ATF/GADD/MAX/TP53 Signaling
TGFBR -> MEF/MYOD/MYOG Signaling
TNF-alpha/TNFRSF1A Signaling
TGF-beta Signaling
BMPR2 Signaling
P38 MAPK/MAPK14 Signaling
AXL Receptor Tyrosine Kinase Signaling
PI3K/RAC1 Signaling
TNF-alpha/TNFRSF1B Signaling
KRAS Signaling
VEGF Signaling
TCR -> CREB/CREBBP/ATF Expression Targets
T-Cell Receptor -> NFATC Signaling
T-Cell Receptor -> ATF/CREB Signaling
TGFA -> TP53 Expression Targets
TGFA -> MEF/MYOD/NFATC Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> NF-kB Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF5/6 -> RB1/E2F Signaling
NGFR -> NF-kB Signaling
TNFR -> NF-kB Signaling
NGFR -> MEF Signaling
TNFRSF6 -> DDIT3 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
TLR4 -> AP-1/EGR1/HIF1A Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
TLR -> AP-1 Signaling
ER Stress (Unfolded Protein Response)
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> NFATC Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> NFATC Signaling
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
pathway 3
e
pathway 4
ace2
New Pathway (2)
cypa
sars-cov no binding
dsRNA induces innate immunity and INFs in alveolar cells
1_Inflammation in keratinocytes in the pathology of acne
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
1_Osteoclast-mediated bone resorption in postmenopausal women
1_Osteoclast functional impairment in osteopetrosis
2_Chondrocyte death in osteoarthritis
2_The role of endothelial cells in pyelonephritis
3_The role of interstitial fibroblasts in pyelonephritis
3_Mesangial cell dysfunction in glomerulonephritis
2_Podocyte dysfunction in glomerulonephritis
3_Role of neurotrophic factor deprivation in retinal ganglion cell death
2_Pathogens stimulate mucins expression in the middle ear
2_Oxidized LDL causes endothelial dysfunction in atherosclerosis
2_Cardiomyocyte hypertrophy
3_Cardiomyocyte dysfunction unrelated to cell junctions in ARVD
4_Inflammatory mediators inhibit GATA signaling in erythropoiesis
4_2_Insulin resistance: inflammation-related insulin resistance
4_3_Insulin resistance: FFA-related insulin resistance
drug-target moltransport
DIPG overview_1 (histones)
New Pathway (1)
mapk1
New Pathway
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group other partners for SARS

Source curated
ResNet
GO component
Biopax

MedScan ID 1432

LocusLink ID 1432
26416
81649
12975
326416
282273
534492
65237
321438
336914

Alias Csaids-binding protein
mitogen-activated protein kinase p38 alpha
mitogen-activated protein kinase p38
tRNA synthetase cofactor p38
cytokine suppressive anti-inflammatory drug-binding protein
LOC101929346
p38/Mpk2
MAPK p38alpha
p38alpha Exip
cytokine suppressive anti-inflammatory drug binding protein
MAX-interacting protein II
CSBP2
PRKM15
MAX-interactive protein 2
CSBP/p38 MAPK
CSBP/p38 MAP kinase
cytokine-supressive anti-inflammatory drug-binding protein
CSAID-binding protein
OTTMUSP00000021707
MAP kinase p38 alpha
Mpk2/p38
RP24-137E7.1
CSPB I
p38 mitogen activated protein kinase
CSBP/p38 kinase
MAP kinase p38
p38ALPHA
p38alpha mitogen-activated protein kinase
Crk1
MAX-interacting protein 2
CSBP
Exip
MAP kinase MXI2
CSPB1
MAP kinase 14
RP1-179N16.5
PRKM14
p38 SAPK
mitogen-activated protein kinase 14A
MGC105413
OTTMUSP00000021708
MAX-interactive protein II
p38 MAP kinase
Mxi2
stress-activated protein kinase p38
p38Hog
OTTMUSP00000021706
p38a
p38 MAP kinase alpha
CSBP1
OTTHUMP00000216566
OTTHUMP00000216563
Csaids binding protein
MAPK14
mitogen activated protein kinase 14
MGC102436
cytokine suppressive anti-inflammatory drug binding protein 1
tRNA synthase cofactor p38
cytokine-supressive anti-inflammatory drug binding protein
CSBP I
cytokine suppressive anti-inflammatory drug binding protein I
p38MAPK
CSAID binding protein
MAPK p38
p38alpha MAPK
OTTMUSP00000021709
p38alpha MAP kinase
SAPK2A
p38 kinase
stress-activated protein kinase 2A
RK
p38
mitogen-activated protein kinase 14
p38-alpha
MAPK 14
p38 MAPK
Hog
MAP kinase 2
reactive kinase
p38 alpha
Mitogen-activated protein kinase p38
PRKM14s
PRKM15s
MAPK14s
Lil I
Serum cholesterol level QTL XII
Serum cholesterol level QTL 12
P-38
Lil1
Lipid Level QTL 1
Scl12
Lipid Level QTL I

EC Number 2.7.11.24
2.7.1.37
2.7.1.-
2.7.11.1

GO ID 0005524
0004707
0004708
0051525
0019899
0048273
0019903
0004674
0070935
0000077
0007265
0000187
0001525
0006915
0001502
0000902
0007166
0071479
0071222
0071223
0071310
0071356
0035924
0098586
0006935
0002062
0019395
0006006
0035556
0031663
0090090
0043312
0030316
0038066
0018105
0001890
0043536
0090336
0060045
0031281
0002741
0045648
0010628
0046326
2001184
0010759
1905050
0051149
0045663
1901741
0010831
0042307
2000379
0045944
0051090
1900015
0010468
0030278
1901796
0099179
0006357
0032495
0035994
0007165
0042770
0007519
0090400
0051146
0007178
0048010
0005737
0005829
0005576
1904813
0098978
0005739
0016607
0005654
0005634
0034774
0000922
0016301
0000166
0008022
0004672
0016740
0006974
0014835
0016310
0046777
0006468
0006355
0032496
0051403
0005623
0009749
0005622
0045087
0002756
0002755
0016071
0007243
0016070
0007005
0006950
0005515
0071363
0035666
0008063
0044445
0070062
0048011
0034166
0038123
0038124
0034162
0007596
0002224
0000165
0006996
0034146
0034142
0006351
0042692
0023014
0006928
0010467
0034134
0034138
0034130
0030168
0016772
0008152
0005625
0008339
0004682
0006960
0004713
0019735
0004691
0040016

KEGG ID hsa:1432
mmu:26416
rno:81649

MedLine Reference 10601328
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11466386
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11925444
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11994045
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16542681
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16895802
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17034759
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9513091
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10629051
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11960370
11997522
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12819782
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12937170
12947324
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14561730
14578350
14585994
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14592977
14593000
14606520
14617800
14622137
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14634061
14665434
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14712227
14718543
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15024092
15031106
15102471
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15232685
15240007
15282297
15287722
15289440
15316018
15319438
15345139
15381256
15385464
15388329
15459198
15483225
15485852
15509711
15523637
15537893
15557738
15561967
15567067
15572149
15572667
15590669
15601830
15611087
15625301
15630166
15632024
15648447
15649893
15652346
15661878
15687248
15691843
15708845
15735648
15746179
15760340
15761494
15761973
15764603
15767263
15767678
15772134
15778378
15778394
15782199
15795936
15808838
15817653
15824134
15833736
15836771
15837794
15850458
15864310
15870258
15890335
15893881
15905332
15907784
15910777
15919053
15923604
15936714
15946254
15955110
15964803
15971269
15979729
16020390
16098594
16116476
16120811
16135819
16138010
16141072
16141073
16143643
16156785
16169504
16207331
16217033
16272151
16275897
16288922
16289764
16297369
16306704
16357362
16364914
16387856
16400028
16443758
16481366
16492136
16507991
16547729
16571868
16585552
16595708
16603589
16616932
16632522
16650898
16699960
16714293
16751104
16775014
16849316
16849392
16880512
16887817
16912279
16920928
16935932
16936205
16966377
16979163
17015449
17028194
17030606
17052691
17071578
17074887
17077290
17083486
17088247
17090686
17105401
17105766
17139251
17214902
8444355
8449498
8925912
9806642
10085140
10206983
10330143
10348343
10364159
10391943
10415025
10557092
10559944
10581258
10597297
10644717
10706854
10727080
10747897
10779345
10805738
10806207
10838079
10849446
10857861
1088347
10884347
10910078
10912793
10942774
10961885
10978317
10980603
11042204
11042694
11157753
11226159
11259586
11333986
11344273
11346645
11359773
11377386
11387337
11390380
11416124
11489891
11495898
11551930
11551945
11602244
11604491
11691836
11741533
11756422
11773065
11777913
11781324
11788583
11788789
11847341
11848686
11852102
11866441
11896401
11994493
12009331
12051955
12067303
12071847
12085235
12105188
12110590
12126643
12138194
12164931
12170268
12171600
12183063
12200131
12225289
12296996
12370831
12391307
12429732
12473116
12505871
12509443
12519482
12589052
12595530
12606502
12631076
12654092
12663671
12665511
12665801
12684028
12697810
12698197
12702497
12761180
12784337
12810082
12855667
12882963
12897141
12933809
13679851
14512875
14552880
14586399
14648593
14714552
14715645
14970175
14989597
15132952
15133024
15170913
15245437
15246972
15256218
15257094
15273249
15284239
15292176
15292225
15304097
15304486
15310753
15315972
15322009
15345584
15375157
15383283
15388348
15489375
15514847
15516490
15527495
15541600
15542843
15550393
15569672
15578697
15592496
15625302
15629715
15632082
15650392
15665518
15668322
15677464
15728454
15737629
15737736
15753227
15778365
15784503
15790570
15791651
15797859
15843433
15845648
15849811
15851480
15862947
15894558
15901830
15917247
15946948
15950779
15964514
16027723
16027724
16098034
16099944
16123320
16133687
16135815
16138080
16139274
16153249
16153436
16164755
16189514
16197369
16214108
16242072
16251188
16256071
16256948
16257181
16278378
16308312
16338464
16342939
16344056
16351573
16380078
16410245
16410316
16446363
16467496
16469115
16478922
16516911
16538384
16554354
16581800
16613612
16627995
16636664
16645187
16648477
16648633
16683917
16697418
16699462
16699726
16709866
16720051
16769768
16790501
16820791
16843435
16861915
16864945
16869889
16899715
16912047
16924420
16964394
16973972
17030506
17030510
17035228
17050539
17054722
17055984
17059827
17107667
17141198
17142767
7479834
7493921
7535770
7592979
7696354
7716521
7750576
7839144
7997261
8083223
8274451
8530093
8548291
8622669
8626699
8650547
8695800
8798479
8846784
8917518
9069290
9092573
9130707
9155018
9211903
9278512
9295308
9405468
9465032
9554853
9628874
9753748
9768359
9788880
9792677
9858528
9878398
9889198
12140684
14576193
14588145
15475493
10995439
11116087
16456712
16774848
14574404
15489334
15592455
16532349
16814421
16924234
16927023
16935849
16951426
17000004
17012370
17081983
17085432
17126905
17188240
17192257
17196171
17202865
17207971
17234706
17241234
17244678
17255097
17255949
17277157
17284589
17303382
17303384
17307333
17316568
17332506
17341442
17347580
17373649
17406030
17438131
17446930
17464174
17468755
17519236
17524358
17531530
17543571
17548358
17583675
17612563
17613714
17616668
17624368
17675521
7923354
8910361
9095200
9753691
11593045
12872135
16177070
16413747
16442778
16476765
16514068
16574378
16806764
16844343
16889766
16924238
16937126
16978838
17040971
17117477
17158101
17158963
17167049
17182102
17185377
17187070
17194700
17202326
17210568
17219434
17234967
17244351
17255352
17267699
17277164
17291992
17292829
17304211
17334779
17344394
17346981
17362930
17373651
17441692
17464186
17467682
17468757
17481611
17490618
17534150
17544802
17574041
17588539
17613723
17621549
17658519
17699753
9122194
16983391
17069850
17133350
17151195
17172269
17196178
17208994
17235686
17293487
17308014
17333127
17401436
17467311
17488713
17496214
17583725
17609504
17882791

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio
Human

Mouse chromosome position 17 14.85 cM
17 13.5 cM

OMIM ID 600289
61407
OMIM:600289

Rat chromosome position 20p12

Hugo ID 6876
HGNC:6876

Human chromosome position 6p21.31
6p21.3-p21.2

Swiss-Prot Accession L7RSM2
Q16539
A0A024RD15
B4E0K5
Q16539.3
P47811
Q5U421
P47811.3
Q56A33
G3V617
P70618.3
A6ZJ92
A8K6P4
B0LPH0
B5TY32
O60776
Q13083
Q14084
Q8TDX0
B2KF37
B2KF38
O08666
Q3U6R5
Q3UZS3
Q8C289
Q9JLV8
Q9QZ80
P70618
Q15454
MK14_HUMAN
MK14_MOUSE
B2KF37_MOUSE
Q56A33_RAT

PIR ID S53536
I49066

GenBank ID NC_000006
XR_926065
NM_139012
NP_620581
NM_139014
NP_620583
NM_001315
NP_001306
XM_011514310
XP_011512612
XM_017010300
XP_016865789
XM_017010299
XP_016865788
XM_017010301
XP_016865790
XM_017010304
XP_016865793
XM_017010303
XP_016865792
XM_017010302
XP_016865791
NM_139013
NP_620582
XM_006714998
XP_006715061
CH471081
EAX03867
EAX03868
EAX03869
EAX03870
EAX03871
EAX03872
EAX03873
EU332860
ABY87549
JD591565
CIW96073
JX512452
AGC09599
U19775
AAC50329
Z95152
AB074150
BAB85654
AF100544
AAF36770
AK291709
BAF84398
AK303414
BAG64467
BC000092
AAH00092
BC031574
AAH31574
BT006933
AAP35579
CR536505
CAG38743
DA438432
FJ032367
ACI00233
FJ032368
ACI00234
L35263
AAA57455
L35264
AAA57456
Z25432
CAA80919
Q16539
NC_000083
NM_001168514
NP_001161986
NM_011951
NP_036081
NM_001168508
NP_001161980
XM_017317480
XP_017172969
NM_001168513
NP_001161985
NT_187005
NM_001357724
AC170998
CH466606
EDL22584
EDL22585
EDL22586
EDL22587
CT009661
JD591567
CIW96269
AF128892
AAF34818
AF195850
AAF06348
AI132714
AK089059
BAC40726
AK133684
BAE21782
AK151348
BAE30324
AK153025
BAE31659
AK177608
AK178357
AK185139
AK191704
AK192555
AK195023
AK199780
AK201673
AK205426
AK210155
AK210810
AK216421
AK218544
AK219197
BC012235
AAH12235
BC018227
BC085303
AAH85303
CX568915
D83073
BAA19741
U10871
AAA20888
W66694
X65067
CAA46200
P47811
NC_005119
XM_017601781
XP_017457270
XM_006256142
XP_006256204
NM_031020
NP_112282
AC_000088
AABR07044432
AABR07044433
AABR07044434
AAHX01099785
CH473988
EDL96934
EDL96935
EDL96936
EDL96937
AB000783
BAF80890
AF346293
AAK15541
BC092193
AAH92193
U73142
AAC71059
U91847
AAB51285
P70618
AABR06099920
AABR06099918
AABR06099919
AMYH02013551
AC_000039
XR_926067
XR_926068
XM_011514311
XP_006524368
XP_006524367
ABBA01038251
AC_000138
ABBA01038250
AAHY01131921
ABBA01038249
CAQ52037
CAQ52035
CAQ52036
CAQ52033
CAQ52034
XM_006524305
XP_011512613
XM_006524304
XR_241882
NC_018917
NT_007592
NW_923073
NW_001838980
AC_000049
CR598726
CR612713
Q15454
NT_039649
NT_165782
NW_001030605
Q5U421
NW_047597
NW_001084789
Q56A33
1621646
1621647
20986515
20986516
6996646
6996647
NW_000124
34852317
1181606
3036773
10092589
3392894
3392895
4503069
4503068
26354195
51465701
2499600
2499601
1136798
1136797
NT_086693
CAB08440
603917
603918
51465675
603916
603919
19071869
19071868
50551
BG087465
50552
30582705
30582704
405743
405742
7109717
7109716
17390519
1945623
51770238
55154531
55154530
1916984
26354196
12652686
13194758
12652687
NT_039548
15126598
15126597
1916983
1346566
13194757
21594896
CAB08439
21594895
6273386
13591927
6273387
13591928
531125
NW_043430
531124
10092590
49168495
49168496
20986513
20986514
20986511
20986512
62089482
81909362
74191494
74225499
74227417
81910272
119624273
119624274
119624275
119624276
119624277
119624278
74706557
BE589157
BM434141
CK981031
NC_007324
NW_001494145
XM_614274
XP_614274
30316123
37589891
9836500
AAH44128
AB030897
AI353982
AL929282
BAB11807
BC044128
BC059417
BE693168
NC_007119
NM_131722
NP_571797
NW_001513952
Q9DGE2
AW595028
119624272
148690637
148690638
148690639
148690640
149043483
149043484
149043485
149043486
O60776

Swiss-Prot ID MK14_HUMAN
MK14_MOUSE
Q56A33_RAT
Q5U421_MOUSE
B2KF37_MOUSE

Cell Localization Cytoplasm
Nucleus

Ensembl ID ENSG00000112062
ENSP00000229795.3
ENST00000229795.7
ENSP00000229794.4
ENST00000229794.8
ENSP00000308669.4
ENST00000310795.8
ENSP00000419837.1
ENST00000468133.5
ENSMUSG00000053436
ENSMUSP00000004990.6
ENSMUST00000004990.13
ENSMUSP00000110400.1
ENSMUST00000114752.2
ENSMUSP00000110402.1
ENSMUST00000114754.7
ENSMUSP00000061958.8
ENSMUST00000062694.15
ENSRNOG00000000513
ENSRNOP00000000617.3
ENSRNOT00000000617.8
ENSRNOP00000000618.2
ENSRNOT00000000618.6
ENSMUSP00000061958
ENST00000310795
ENSMUST00000062694.14
ENSMUST00000004990.12
ENSP00000308669
ENSMUST00000004990
ENST00000229794
ENSMUSP00000004990
ENSMUSP00000110400
ENSP00000229794
ENSMUSP00000110402
ENSP00000419141
ENSRNOT00000000617
ENSP00000229795
ENSRNOT00000000618
ENST00000229795
ENST00000468133
ENSMUST00000114754
ENSMUST00000114752
ENSP00000419837
ENSRNOP00000000618
ENSRNOP00000000617
ENSMUST00000062694
ENST00000472333

MGI ID MGI:1346865
1346865
1338028

RGD ID 70496
61407

Unigene ID Mm.311337
Rn.88085
Hs.485233
Hs.588289
Mm.4437
Mm.347796
Hs.79107
Bt.11377
Dr.72252
Hs.719314
Hs.722031

Homologene ID 31777

Shape Sickle-vertex

IPI ID IPI00816843
IPI00221141
IPI00331732
IPI00828805
IPI00221143
IPI00221142
IPI00002857
IPI00112346
IPI00230807
IPI00830415
IPI00190530
IPI00829435
IPI00558535

Microarray ID 99978_s_at
1367697_at
U73142_at
U73142_g_at
U91847_s_at
rc_aa924542_s_at
rc_ai137862_s_at
rc_ai171630_s_at
A_43_P12479
NM_031020
1416703_at
1416704_at
1426104_at
1451927_a_at
u10871_s_at
Msa.8386.0_s_at
Msa.343.0_at
Msa.8386.0_at
A_65_P02959
L0241G04-3
A_51_P325343
NM_011951
A_65_P19663
AF195850.1
L35263
37733_at
78240_at
1671_s_at
202530_at
210449_x_at
211087_x_at
211561_x_at
1999_s_at
L35263_at
L35253_s_at
A_23_P214696
I_957350
A_23_P426292
A_14_P139376
A_14_P138042
A_14_P129108
A_14_P111428
A_24_P283288
A_24_P397566
704
OH7873
M190
R519
OR0693

Homo sapiens Chromosome position 6p21.3-p21.2

Ensembl Transcript ID ENST00000229794
ENST00000229795
ENST00000310795

ENSEMBL ENSG00000112062

FunctionalClass MAP kinase
MAP kinase kinase
MP kinase
kinase
protein C-terminus binding
protein binding
protein kinase
protein-tyrosine kinase
ATP binding
nucleotide binding
protein serine/threonine kinase
transferase
cAMP-dependent protein kinase
protein kinase CK2

Hugo Symbol MAPK14

Bos taurus Chromosome position 23

Mus musculus Chromosome position 17 13.5 cM

KEGG pathway Toll-like receptor signaling pathway
MAPK signaling pathway
Fc epsilon RI signaling pathway
GnRH signaling pathway
Leukocyte transendothelial migration
VEGF signaling pathway

ProteinAtlas SubcellularLocation Main location: Vesicles; Other location: Nucleus but not nucleoli;Cytoplasm;Golgi apparatus; Expression type: Staining; Reliability: Uncertain

State isoform 1
isoform 2
isoform 3
isoform 4
p

Rattus norvegicus Chromosome position 20p12

Ensembl Gene ID ENSG00000112062

Keyword map kinase
ERK activator kinase
tumor necrosis factor
SAP kinase
MAP kinase kinase kinase
phospholipase C
map kinases

ProteinAtlas NormalTissue Tissue: liver; Cell type: hepatocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: lung; Cell type: pneumocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: adrenal gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: appendix; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: appendix; Cell type: lymphoid tissue; Level: Low; Expression type: APE; Reliability: Low
Tissue: bone marrow; Cell type: hematopoietic cells; Level: High; Expression type: APE; Reliability: Low
Tissue: breast; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: cerebellum; Cell type: cells in granular layer; Level: Low; Expression type: APE; Reliability: Low
Tissue: cerebellum; Cell type: cells in molecular layer; Level: None; Expression type: APE; Reliability: Low
Tissue: cerebellum; Cell type: Purkinje cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cerebral cortex; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: cervix, uterine; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: colon; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: duodenum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: epididymis; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: fallopian tube; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: gall bladder; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: heart muscle; Cell type: myocytes; Level: Low; Expression type: APE; Reliability: Low
Tissue: hippocampus; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: hippocampus; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: kidney; Cell type: cells in glomeruli; Level: Low; Expression type: APE; Reliability: Low
Tissue: kidney; Cell type: cells in tubules; Level: Medium; Expression type: APE; Reliability: Low
Tissue: lateral ventricle; Cell type: glial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: liver; Cell type: bile duct cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: lung; Cell type: macrophages; Level: Medium; Expression type: APE; Reliability: Low
Tissue: lymph node; Cell type: germinal center cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: lymph node; Cell type: non-germinal center cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: ovary; Cell type: follicle cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: ovary; Cell type: ovarian stroma cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: pancreas; Cell type: islets of Langerhans; Level: Low; Expression type: APE; Reliability: Low
Tissue: parathyroid gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: placenta; Cell type: decidual cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: placenta; Cell type: trophoblastic cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: prostate; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: rectum; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: salivary gland; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: seminal vesicle; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: skeletal muscle; Cell type: myocytes; Level: Medium; Expression type: APE; Reliability: Low
Tissue: skin; Cell type: epidermal cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: small intestine; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: spleen; Cell type: cells in red pulp; Level: Medium; Expression type: APE; Reliability: Low
Tissue: spleen; Cell type: cells in white pulp; Level: Low; Expression type: APE; Reliability: Low
Tissue: stomach, lower; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: stomach, upper; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Medium; Expression type: APE; Reliability: Low
Tissue: testis; Cell type: Leydig cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: thyroid gland; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: tonsil; Cell type: germinal center cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: tonsil; Cell type: non-germinal center cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: urinary bladder; Cell type: urothelial cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: None; Expression type: APE; Reliability: Low
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Medium; Expression type: APE; Reliability: Low
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Low; Expression type: APE; Reliability: Low
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: vagina; Cell type: squamous epithelial cells; Level: Low; Expression type: APE; Reliability: Low
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Low; Expression type: APE; Reliability: Low

State Description Transcript Variant: This variant (1) encodes the longest isoform (1).
Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1.
Transcript Variant: This variant (3) contains a different internal segment within the coding region, and a different 3' coding region as well as a different 3' UTR, when compared to variant 1. It thus encodes an isoform that has a different internal se...
Transcript Variant: This variant (4) contains a different internal segment when compared to variant 1. It thus encodes an isoform that has a different and shorter internal segment, as compared to isoform 1.

EnzymeConsortium 2.7.1.37