Protein CXCL8

URN urn:agi-llid:3576
Total Entities 0
Connectivity 13044
Name CXCL8
Description chemokine (C-X-C motif) ligand 8
Notes The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]
Primary Cell Localization Extracellular
Class Ligand

Pathway Proteins Involved in Stem Cell Exhaustion in Aging
ECL-cell: CHGA and Histamine Synthesis
Cortisol in Resolving Inflammation
Toll-like Receptors Act through MYD88-TIRAP Signaling
TLR4 Signaling in Leukocytes
T-Cell Maturation (Hypothesis)
CXC Chemokine Receptor Signaling
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Toll-like Receptors in Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
MC1R in anti-Inflammatory Signaling
Find me Signal: Apoptotic Cell Attracts Phagocyte
Lipids Enhance Apoptotic Cell Engulfment and Reduce Inflammation
Keep out Signal: LTF Inhibits Neutrophil Recruitment and Inflammation
Leukotriene Effect on Vascular Endothelial Cell Response
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation through TNFSF8 Signaling
Mast-Cell Activation via IgE Signaling
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cell Activation without Degranulation through CXCR4 Signaling
Mast-Cell Activation without Degranulation
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Mast-Cell Activation without Degranulation through IL1R1 and TLR Signaling
Neutrophil Recruitment and Priming
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Nociception Expression Targets Signaling
NTSR1 Expression Targets
BDKRB1/2 -> Interleukins Production
PTGER2/3 -> Inflammation-Related Expression Targets
TACR1 -> TNF/IL6/IL8 Production
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
CHRNA7 -> IL8 Production
P2RY11/13/14 -> IL8/10 Production
Proteins Involved in Atherosclerosis
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
Dendritic Cells Function in Atherosclerosis
Proteins Involved in Arterial Hypertension
Arterial Hypertension
Proteins Involved in Myocardial Ischemia
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Proteins Involved in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Mast-Cells Activation in Atopic Dermatitis
Proteins with Altered Expression in Melanoma
Melanoma
Proteins Involved in Melanoma
IL17 Signaling in Psoriasis
Proteins Involved in Psoriasis
Oxidative Stress in Vitiligo
Proteins with Altered Expression in Vitiligo
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Proteins Involved in Diabetic Nephropathy
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
Proteins Involved in non-Alcoholic Fatty Liver Disease
Proteins Involved in Obesity
Proteins Involved in Colorectal Neoplasms
Metastatic Colorectal Cancer
Paneth-Cell Function in Crohn's Disease
Proteins Involved in Inflammatory Bowel Diseases
OipA Signaling in Helicobacter Pylori Infection
Proteins Involved in Helicobacter Infections
CagA Phosphorylation Independent Signaling
Leukocyte Migration toward the Endothelial Cell in Ulcerative Colitis
Proteins Involved in Ulcerative Colitis
Antiphospholipid Antibodies in Endothelial Cell
Hodgkin and Reed-Sternberg Cells in Hodgkin Lymphoma
Hodgkin Lymphoma
TNFR/NF-kB Classical Pathway in Multiple Myeloma Plasma Cells
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
NOTCH Signaling in Multiple Myeloma
TNFR/NF-kB Alternative Pathway in Multiple Myeloma Plasma Cells
Antiphospholipid Antibodies and Endothelial Cell Interaction
SERPINA1 Associated Liver Damage
Proteins Involved in Pancreatic Cancer
TRPM7/8 in Pancreatic Adenocarcinoma
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
Neutrophil Degranulation via FPR1/IL8
Mast-Cell Activation in Asthma
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF
Proteins Involved in Cystic Fibrosis
Airway Epithelial Cell Dysfunction
CFTR Related Ion-Channel Dysfunction in Cystic Fibrosis Airway Epithelium (Class III Mutations)
Proteins Involved in Gout
Proteins with Altered Expression in Gout
Neutrophil Recruitment in Sinovium in Gout
Monocytes Function in Gout
Proteins Involved in Osteoarthritis
Synovial Fibroblast Activation in Psoriatic Arthritis
Keratinocyte Activation in Psoriatic Arthritis
Synovial Fibroblast Activation by Citokines in Rheumatoid Arthritis
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Proteins Involved in Rheumatoid Arthritis
FAS Mediated Apoptosis in Systemic Scleroderma
Genes with Mutations Associated with Systemic Scleroderma
Proteins Involved in Systemic Scleroderma
Toll-like Receptors (TLR) in Periodontitis
Diabetes Induced Periodontitis
Estrogen Effects on Pregnancy Gingivitis
Proteins Involved in Periodontitis
IL36 Receptor Antagonist (IL1F5) Deficiency (DITRA)
NF-kB Signaling Activation in Huntington Disease
Proteins with Altered Expression in Psoriatic Arthritis
Proteins with Altered Expression in Rheumatoid Arthritis
Proteins Involved in Ependymoma
Proteins Involved in Glioma
Proteins Involved in Adhesion, Migration and Invasion of Endometriotic Cell
Proteins Involved in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Proteins Involved in Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Cholesteatoma
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Proteins Involved in Age-Related Macular Degeneration
ER Stress in Macular Degeneration
Proteins Involved in Otitis Media
Cytokines Trigger Otitis Media
Proteins with Altered Expression in Asthma
Alveolar Macrophage Negative Regulation Declined in COPD
Alveolar Macrophages Dysfunction in COPD
Glucocorticoid Resistance
Proteins Involved in Chronic Obstructive Pulmonary Disease
Alveolar Epithelial Cell Dysfunction in COPD
Proteins Involved in Chronic Bronchitis
Genes with Mutations Associated with Cystic Fibrosis
Proteins Involved in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Proteins Involved in Pyelonephritis
Proteins with Altered Expression in Pyelonephritis
Toll-like Receptors in Pyelonephritis
Endothelial Cell Dysfunction in Pyelonephritis
AREG -> CREB/CREBBP Expression Targets
AREG -> NCOR2 Expression Targets
AREG -> CTNN Expression Targets
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
Elevated Receptors -> Expression Targets in Joint
Elevated Receptors -> Expression Targets in Bone and Joint
Elevated Receptors -> Expression Targets in Blood vessel
Elevated Receptors -> Expression Targets in Blood Vessel
CXCL6 Expression Targets
CXCL2 Expression Targets
CXCL5 Expression Targets
CXCL12 Expression Targets
CCL3 Expression Targets
IL8 Expression Targets
CSF3 Expression Targets
CSF2 -> NF-kB Expression Targets
CSF2 -> STAT Expression Targets
LIF Expression Targets
EGF -> CTNN Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> MEF/MYOD/NFATC Expression Targets
EGF -> STAT Expression Targets
PECAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> STAT1/NF-kB Expression Targets
FGF18 -> STAT Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF1 -> STAT Expression Targets
Elevated Receptors -> Expression Targets in Mouth
Elevated Receptors -> Expression Targets in Colon
HBEGF -> STAT Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HGF -> STAT Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
EGFR Transactivation in Cancer and Non-Cancer Cells
TAM Receptor Signaling Activation in Cancer
ANGPT/TEK Maintains Endothelial Cell Quiescence in Cancer
Lactate as a Signaling Molecule in Cancer Cells
Proteins with Altered Expression in Cancer Metabolic Reprogramming
Tumor Infiltrating Macrophages in Cancer Progression and Immune Escape
IGF1 -> MEF/MYOD/MYOG Expression Targets
IGF1 -> STAT Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
Fibrinogen Expression Targets
EGFR -> Expression Targets in Skin
IFNB1/IFNR Expression Targets
IFNG/IFNR Expression Targets
IL7 Expression Targets
IL13 Expression Targets
IL15 Expression Targets
IL3 Expression Targets
IL10 Expression Targets
IL11 Expression Targets
IL2 Expression Targets
Leptin -> STAT Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Morphine Expression Targets
PAF/Gq -> NF-kB Expression Targets
S1P Expression Targets
Proteins/Ions Transporters -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Lymphoid System and Blood
F2R/F2RL1 -> Expression Targets in Lymphoid System and Blood
CD Markers -> Expression Targets in Lymphoid System and Blood
GPCRs Family -> Expression Targets in Lymphoid System and Blood
Cell Adhesion Receptors -> Expression Targets in Lymphoid System and Blood
TNF Receptors -> Expression Targets in Lymphoid System and Blood
Receptor Tyrosine Kinase Family -> Expression Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Bone Marrow
Interleukin Receptors -> Expression Targets in Lymphoid System and Blood
C5AR1 -> Expression Targets in Lymphoid System and Blood
IgE Receptors -> Targets in Lymphoid System and Blood
Elevated Receptors -> Expression Targets in Thymus
NGF -> SMAD3/NF-kB Expression Targets
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
Adenosine Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
PDGF -> STAT Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
GNRH2 Expression Targets
POMC Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
IFNA1/Gq Expression Targets
TAC1 Expression Targets
AGT -> STAT Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
CSF1 -> STAT Expression Targets
GAS6 -> AP-1/CREB Expression Targets
KITLG -> STAT Expression Targets
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
PAF Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
Elevated Receptors -> Expression Targets in Endometrium
Elevated Receptors -> Expression Targets in Lung
MERTK Signaling
TCR -> AP-1 Expression Targets
TGFA -> STAT Expression Targets
TGFA -> CTNNB/CTNND Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFB1-TGFBR2 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TGFB1-ACVRL1 Expression Targets
FASLG Expression Targets
TNF -> NF-kB Expression Targets
TNFSF10 Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNF -> CREB Expression Targets
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
TLR3 Expression Targets
TLR4 -> AP-1 Expression Targets
TLR5 Expression Targets
TLR7 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
TLR1 -> 2/6 Expression Targets
IL1B Expression Targets
TLR4 -> NF-kB/IRF Expression Targets
IL1A Expression Targets
TLR9 Expression Targets
ROS in Triggering Vascular Inflammation
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFA -> STAT Expression Targets
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFA -> CTNNB/CTNND Expression Targets
WNT1 Expression Targets
WNT5A Expression Targets
WNT Canonical Signaling Expression Targets
pathway 3
pathway 4
ace2
New Pathway (2)
PPAR Psoriasis
pprarg neg, uknown targets, ps-positive
prarg neg,ukn expres targets, ps-positive
PPARG negative targets
pparg expr target_regulators
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of exhaustion
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of tumor aggressiveness
Neighbors of tumor resistance
Neighbors of median survival
Neighbors of cancer recurrence
Neighbors of antimetastatic activity
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of gastric cancer risk
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of fibroblast phenotype
Neighbors of disease exacerbation
Neighbors of tumor progression
Neighbors of cancer progression
Neighbors of inflammatory status
Neighbors of overall survival
Neighbors of disease severity
Neighbors of tumor size
Neighbors of lesion size
Neighbors of mortality
Neighbors of survival rate
Neighbors of infarct size
Neighbors of survival time
Neighbors of insulin sensitivity
Neighbors of bacterial load
Neighbors of cancer survival
Neighbors of therapeutic efficacy
Neighbors of clinical stage
Neighbors of lethality
Neighbors of tumor regression
Neighbors of recurrence-free survival
Neighbors of disease-free survival
Neighbors of tumor response
Neighbors of macrophage count
Neighbors of long-term survival
Neighbors of treatment outcome
Neighbors of body weight
Neighbors of body weight gain
Neighbors of cardiovascular risk
Neighbors of microvessel density
Neighbors of tumor recurrence
Neighbors of tumor promotion
Neighbors of neutrophil count
Neighbors of morbidity
Neighbors of mortality rate
Neighbors of exhaustion
Neighbors of adverse outcome
Neighbors of radioresistance
Neighbors of cell density
Neighbors of cancer-specific survival
Neighbors of progression-free survival
Neighbors of apoptosis rate
Neighbors of early mortality
Neighbors of shear stress
Neighbors of viral load
Neighbors of blood pressure
Neighbors of leukocyte count
Neighbors of vascular leakage
Neighbors of body mass index
Neighbors of vascular density
Neighbors of muscle mass
Neighbors of cancer risk
Neighbors of tumor aggressiveness
Neighbors of tumor resistance
Neighbors of median survival
Neighbors of cancer recurrence
Neighbors of antimetastatic activity
Neighbors of radiosensitivity
Neighbors of breast cancer risk
Neighbors of proliferation index
Neighbors of cell permeability
Neighbors of pregnancy outcome
Neighbors of gastric cancer risk
Neighbors of recurrence rate
Neighbors of pathological response
Neighbors of lymphocyte count
Neighbors of monocyte count
Neighbors of skin thickness
Neighbors of metabolic response
Neighbors of comorbidity
Neighbors of carotid intima-media thickness
Neighbors of fibroblast phenotype
Neighbors of cell development
Neighbors of immune response
Neighbors of cell population
Neighbors of T-cell development
Neighbors of inflammatory response
Neighbors of wound healing
Neighbors of angiogenesis
Neighbors of innate immune response
Neighbors of cell function
Neighbors of macrophage activation
Neighbors of cell formation
Neighbors of adaptive immune response
Neighbors of osteoclast development
Neighbors of epithelial to mesenchymal transition
Neighbors of immunity
Neighbors of cell proliferative response
Neighbors of chemotaxis
Neighbors of dendritic cell differentiation
Neighbors of cell survival
Neighbors of osteoclast differentiation
Neighbors of cell phenotype
Neighbors of T-cell proliferation
Neighbors of tissue remodeling
Neighbors of cell adhesion
Neighbors of T-cell activation
Neighbors of endothelial cell proliferation
Neighbors of fibrogenesis
Neighbors of tumor growth
Neighbors of dendritic cell development
Neighbors of tissue repair
Neighbors of cell count
Neighbors of cell infiltration
Neighbors of cell interaction
Neighbors of SMC proliferation
Neighbors of lumen formation
Neighbors of endothelial cell migration
Neighbors of adipogenesis
Neighbors of lipid storage
Neighbors of cell damage
Neighbors of pregnancy
Neighbors of monocyte differentiation
Neighbors of aging
Neighbors of cell motility
Neighbors of bone resorption
Neighbors of monocyte migration
Neighbors of fibroblast proliferation
Neighbors of adipocyte differentiation
Neighbors of macrophage migration
Neighbors of microglial activation
Neighbors of neutrophil recruitment
Neighbors of regeneration
Neighbors of cell migration
Neighbors of cancer growth
Neighbors of stem cell proliferation
Neighbors of smooth muscle cell migration
Neighbors of hepatic regeneration
Neighbors of transendothelial migration
Neighbors of phagocytosis
Neighbors of immune system activation
Neighbors of leukocyte migration
Neighbors of leukocyte recruitment
Neighbors of osteoclast formation
Neighbors of monocyte recruitment
Neighbors of cell invasion
Neighbors of heart function
Neighbors of hemopoiesis
Neighbors of bone remodeling
Neighbors of ossification
Neighbors of T-cell function
Neighbors of immune system function
Neighbors of lung development
Neighbors of autophagy
Neighbors of monocyte adhesion
Neighbors of transcription activation
Neighbors of senescence
Neighbors of T-cell response
Neighbors of tumor immunity
Neighbors of hepatocyte proliferation
Neighbors of cell transdifferentiation
Neighbors of neuroprotection
Neighbors of stem cell differentiation
Neighbors of endothelial cell function
Neighbors of neuronal death
Neighbors of cell growth
Neighbors of ROS generation
Neighbors of epithelial cell proliferation
Neighbors of first trimester pregnancy
Neighbors of cancer cell growth
Neighbors of sensitization
Neighbors of hemato-encephalic barrier
Neighbors of cellular immune response
Neighbors of cellular senescence
Neighbors of colony formation
Neighbors of macrophage differentiation
Neighbors of cell differentiation
Neighbors of keratinocyte proliferation
Neighbors of stem cell migration
Neighbors of life span
Neighbors of psoriasis
Neighbors of inflammatory disease
Neighbors of rheumatoid arthritis
Neighbors of atherosclerosis
Neighbors of fibrosis
Neighbors of colitis
Neighbors of arthritis
Neighbors of inflammatory bowel disease
Neighbors of injury
Neighbors of atherogenesis
Neighbors of vascular remodeling
Neighbors of metastasis
Neighbors of carcinogenesis
Neighbors of multiple sclerosis
Neighbors of chronic inflammation
Neighbors of inflammation
Neighbors of tumor microenvironment
Neighbors of pathological angiogenesis
Neighbors of obesity
Neighbors of vascular disease
Neighbors of diabetes mellitus
Neighbors of asthma
Neighbors of pneumonia
Neighbors of hyperplasia
Neighbors of osteoarthritis
Neighbors of liver fibrosis
Neighbors of chronic obstructive pulmonary disease
Neighbors of myocardial infarction
Neighbors of leukocyte infiltration
Neighbors of reperfusion injury
Neighbors of airway inflammation
Neighbors of hepatitis
Neighbors of insulin resistance
Neighbors of infection
Neighbors of vascular injury
Neighbors of renal injury
Neighbors of preeclampsia
Neighbors of macrophage infiltration
Neighbors of liver injury
Neighbors of neuroinflammation
Neighbors of sepsis
Neighbors of death
Neighbors of type 1 diabetes
Neighbors of autoimmune disease
Neighbors of ischemic stroke
Neighbors of dermatitis
Neighbors of neutrophil infiltration
Neighbors of heart disease
Neighbors of diabetic nephropathy
Neighbors of lung injury
Neighbors of immunopathology
Neighbors of systemic sclerosis
Neighbors of hepatocellular carcinoma
Neighbors of autoimmunity
Neighbors of acute lung injury
Neighbors of gastric cancer
Neighbors of atherosclerotic plaque
Neighbors of colorectal cancer
Neighbors of cardiac remodeling
Neighbors of breast cancer
Neighbors of ischemia
Neighbors of systemic lupus erythematosus
Neighbors of melanoma
Neighbors of cartilage degeneration
Neighbors of interstitial fibrosis
Neighbors of neoplasm invasion
Neighbors of kidney disease
Neighbors of heart failure
Neighbors of lung disease
Neighbors of pulmonary fibrosis
Neighbors of cardiovascular disease
Neighbors of stroke
Neighbors of cancer
Neighbors of cerebral ischemia
Neighbors of type 2 diabetes
Neighbors of neoplasm
Neighbors of endometriosis
Neighbors of vasculitis
Neighbors of atrophy
Neighbors of respiratory hypersensitivity
Neighbors of synovitis
Neighbors of coronary artery disease
Neighbors of rupture
Neighbors of endothelial cell dysfunction
Neighbors of liver disease
Neighbors of prostate cancer
Neighbors of hypertrophy
Neighbors of osteolysis
Neighbors of ovarian cancer
Neighbors of pancreatic cancer
Neighbors of hypertension
Neighbors of intimal hyperplasia
Neighbors of allograft rejection
Neighbors of proteinuria
Neighbors of epithelial cell
Neighbors of keratinocyte
Neighbors of vascular smooth muscle cell
Neighbors of umbilical vein endothelial cell
Neighbors of monocyte
Neighbors of endometrial stromal cell
Neighbors of alveolar macrophage
Neighbors of synoviocyte
Neighbors of macrophage
Neighbors of adipocyte
Neighbors of activated monocyte
Neighbors of fibroblast
Neighbors of airway epithelial cell
Neighbors of PBMC
Neighbors of stromal cell
Neighbors of airway smooth muscle cell
Neighbors of osteoblast
Neighbors of pneumocyte
Neighbors of endometrium cell
Neighbors of microglia
Neighbors of trophoblast
Neighbors of intestine epithelium cell
Neighbors of mononuclear cell
Neighbors of hepatic stellate cell
Neighbors of hepatocyte
Neighbors of decidual cell
Neighbors of kidney mesangial cell
Neighbors of endothelial cell
Neighbors of dendritic cell
Neighbors of Kuppfer cell
Neighbors of proadipocyte
Neighbors of kidney tubule cell
Neighbors of inflammatory cell
Neighbors of bone marrow macrophage
Neighbors of peritoneal macrophage
Neighbors of osteoclast
Neighbors of neutrophil
Neighbors of smooth muscle myocyte
Neighbors of astrocyte
Neighbors of bone marrow derived dendritic cell
Neighbors of lung fibroblast
Neighbors of activated T-cell
Neighbors of mesothelial cell
Neighbors of mononuclear phagocyte
Neighbors of capillary endothelial cell
Neighbors of immunocompetent cell
Neighbors of granulocyte
Neighbors of cardiac myocyte
Neighbors of cancer-associated fibroblast
Neighbors of myeloid cell
Neighbors of mesenchymal stroma cell
Neighbors of corneal epithelial cell
Neighbors of cytotrophoblast
Neighbors of stem cell
Neighbors of tumor infiltrating macrophage
Neighbors of sinusoidal cell
Neighbors of B-cell
Neighbors of granulosa cell
Neighbors of leukocyte
Neighbors of chondrocyte
Neighbors of insulin-secreting cell
Neighbors of mesenchymal cell
Neighbors of T-cell
Neighbors of M1 macrophage
Neighbors of myofibroblast
Neighbors of pancreatic stellate cell
Neighbors of mast cell
Neighbors of bone marrow stromal cell
Neighbors of spleen cell
Neighbors of brain capillary endothelial cell
Neighbors of neuroglia
Neighbors of thyroid epithelial cell
Neighbors of aortic smooth muscle cell
Neighbors of hematopoietic cell
Neighbors of adipose macrophage
Neighbors of podocyte
Neighbors of mammary epithelial cell
Neighbors of conventional dendritic cell
Neighbors of pericyte
Neighbors of antigen-presenting cell
Neighbors of epidermis cell
Neighbors of phagocyte
Neighbors of kidney cell
Neighbors of syncytiotrophoblast
Neighbors of lymphocyte
Neighbors of Langerhans cell
Neighbors of decidual natural killer cell
Neighbors of thymic epithelial cell
Neighbors of brain cell
Neighbors of M2 macrophage
Neighbors of peritoneum cell
Neighbors of lymphoid cell
Neighbors of retina cell
Neighbors of blood cell
Neighbors of skin cell
Neighbors of peripheral lymphocyte
Neighbors of activated B-cell
Neighbors of lung
Neighbors of liver
Neighbors of kidney
Neighbors of skin
Neighbors of intestine
Neighbors of lymph node
Neighbors of colon
Neighbors of airway
Neighbors of blood vessel
Neighbors of heart
Neighbors of aorta
Neighbors of gastrointestinal tract
Neighbors of microvessel
Neighbors of bone
Neighbors of placenta
Neighbors of synovial membrane
Neighbors of uterus
Neighbors of esophagus
Neighbors of periodontium
Neighbors of retina
Neighbors of brain
Neighbors of ovary
Neighbors of breast
Neighbors of blood vessel wall
Neighbors of stomach
Neighbors of islets of Langerhans
Neighbors of joint
Neighbors of artery
Neighbors of pancreas
Neighbors of prostate
Neighbors of central nervous system
Neighbors of kidney glomerulus
Neighbors of colorectal region
Neighbors of decidua
Neighbors of amnion
Neighbors of immune system
Neighbors of spleen
Neighbors of peritoneum
Neighbors of allantois
Neighbors of alveolus
Neighbors of uterine cervix
Neighbors of omentum
Neighbors of vein
Neighbors of villus
Neighbors of bronchus
Neighbors of glands
Neighbors of nose
Neighbors of eye
Neighbors of cornea
Neighbors of hippocampus
Neighbors of intervertebral disc
Neighbors of mammary gland
Neighbors of vagina
Neighbors of vitreous body
Neighbors of myelin sheath
Neighbors of bladder
Neighbors of retina blood vessel
Neighbors of nasopharynx
Neighbors of periodontal ligament
Neighbors of salivary gland
Neighbors of trachea
Neighbors of corpus luteum of ovary
Neighbors of nerve
Neighbors of endocrine system
Neighbors of small intestine
Neighbors of amniotic cavity
Neighbors of knee joint
Neighbors of hypothalamus
Neighbors of NF-kB family
Neighbors of oxidized LDL
Neighbors of JNK
Neighbors of IL1 family
Neighbors of PPAR
Neighbors of Jun/Fos
Neighbors of NFKBI
Neighbors of PKC
Neighbors of PI3K
Neighbors of STAT family
Neighbors of mitogen-activated protein kinase
Neighbors of IFNAR ligand
Neighbors of transforming growth factor
Neighbors of TLR
Neighbors of cytokine
Neighbors of interferon
Neighbors of interleukin
Neighbors of JAK
Neighbors of MEK1/2
Neighbors of PDGF
Neighbors of Ras GTPase
Neighbors of ERK1/2
Neighbors of growth factor
Neighbors of PKA
Neighbors of LDL
Neighbors of NF-AT family
Neighbors of beta adrenoceptor
Neighbors of chorionic gonadotropin
Neighbors of IKBK
Neighbors of adipokine
Neighbors of protein tyrosine kinase
Neighbors of NAD(P)H oxidase
Neighbors of IgG
Neighbors of SMAD subfamily
Neighbors of AMPK
Neighbors of LXR
Neighbors of HDL
Neighbors of p38
Neighbors of inflammatory cytokine
Neighbors of IL23
Neighbors of estrogen receptor
Neighbors of T-cell receptor
Neighbors of histone deacetylase
Neighbors of PDGF-BB
Neighbors of IL1R
Neighbors of HIF-1
Neighbors of GPCR
Neighbors of IL12
Neighbors of Notch
Neighbors of prostaglandin-endoperoxide synthase
Neighbors of heat shock protein 90
Neighbors of lectin
Neighbors of fibrinogen
Neighbors of aldehyde reductase
Neighbors of mitogen-activated protein kinase kinase
Neighbors of interleukin-35
Neighbors of TSH
Neighbors of endothelin
Neighbors of NOS
Neighbors of superoxide dismutase
Neighbors of proteasome endopeptidase complex
Neighbors of class nuclear receptor with C4 zinc fingers
Neighbors of non-coding RNA
Neighbors of histone H3
Neighbors of STAT5
Neighbors of alpha2 adrenoceptor
Neighbors of vitronectin receptor (integrin)
Neighbors of PP2A
Neighbors of retinoid-X receptor subfamily
Neighbors of SAPK
Neighbors of WNT
Neighbors of gonadotropins
Neighbors of immunoglobulin
Neighbors of PP2B
Neighbors of phospholipase
Neighbors of AHR subfamily
Neighbors of ITG
Neighbors of endostatins
Neighbors of CD3 complex
Neighbors of relaxin
Neighbors of TLR1/2 heterodimer
Neighbors of TORC1
Neighbors of angiotensin receptor
Neighbors of RA receptor
Neighbors of histone
Neighbors of Rho kinase
Neighbors of neuropeptides
Neighbors of pancreatic elastase
Neighbors of histone acetyltransferase
Neighbors of phosphodiesterase
Neighbors of caspase
Neighbors of phosphoinositide phospholipase C
Neighbors of deacetylase
Neighbors of TLR4/Myd88
comon ps_pos, pprarg_neg targets
Model of PPARG signaling in psoriasis
PPARG negative regulators and targets
Model of PPARG related pathways in psoriasis (short version)
sars-cov no binding
Overview. Diseases of the respiratory (chapter 9)
Overview. Endocrine and metabolic diseases (chapter 4)
1_Inflammation in keratinocytes in the pathology of acne
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The role of Toll-like receptors in pyelonephritis
2_The role of endothelial cells in pyelonephritis
3_Endoplasmic reticulum stress in age-related macular degeneration
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
2_3_Eosinophilia and neutrophilia in asthma: Neutrophil chemotaxis and activation
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
2_Paneth cell dysfunction in Crohn's disease
4_2_Genes with mutations currently associated with ulcerative colitis
3_Leukocyte migration toward the endothelial cells in the intestine microvasculature
4_1_Polymorphisms associated with inflammatory bowel diseases
5_Human papilloma virus E6 and E7 proteins promote epithelial cell proliferation
1_SERPINA1-associated pulmonary emphysema
2_SERPINA1-associated liver damage
drug-target pairs direct regulation
drug-target moltransport
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes Associated with Systemic Lupus Erythematosus
Genes with Mutations Associated with Cystic Fibrosis
Genes with Mutations Associated with Systemic Scleroderma
Chemokines, Growth Factors and Receptors Involved in Cancer Cells Chemotaxis
other partners for SARS

Source curated
GO component

MedScan ID 3576

LocusLink ID 3576
280828
567083

Alias C-X-C motif chemokine ligand 8
IL8_HUMAN
LYNAP
lymphocyte derived neutrophil activating peptide
monocyte-derived neutrophil-activating peptide
LECT
Granulocyte chemotactic protein 1
neutrophil-activating peptide I
IL8
CXC chemokine ligand 8
interleukin IL VIIIs
interleukin IL8
chemokine CXC ligand 8
CXCL8
small inducible cytokine subfamily B, member 8
IL VIII
small inducible cytokine subfamily B, member VIII
Lymphocyte-derived neutrophil- activating factor
Neutrophil-activating factor
polymorphonuclear granulocyte activating factor
Granulocyte chemotactic protein I
IL VIIIs
interleukin VIII
b-ENAP
CXC chemokine ligand VIII
GCP-1
monocyte-derived neutrophil chemotactic factor
neutrophil activating peptide
Neutrophil-activating protein I
GCP I
chemokine CXCL8
C-X-C motif chemokine 8
beta-thromboglobulin-like protein
neutrophil-activating peptide 1
beta endothelial cell-derived neutrophil activating peptide
granulocyte chemotactic peptide
LUCT
MONAP
lung giant cell carcinoma-derived chemotactic protein
LUCT/interleukin-8
interleukin 8
interleukin IL VIII
alveolar macrophage chemotactic factor I
neutrophil attracting peptide
monocyte derived neutrophil-activating protein
OTTHUMP00000199825
interleukin IL8_HUMAN
MDNCF
T-cell chemotactic factor
CXCL8 chemokine
AMCF-I
chemokine (C-X-C motif) ligand 8
LOC133094
SCYB8
Neutrophil-activating protein 1
3-10C
NAF
GCP1
NAP1
NAP-1
emoctakin
tumor necrosis factor-induced gene 1
interleukin-8
IL[8]
T cell chemotactic factor
lymphocyte-derived neutrophil-activating factor
Interleukin-IL8
Neutrophil- activating protein 1
Neutrophil-activating factor
Neutrophil- activating protein I
K60
TSG-1
Monocyte-derived neutrophil chemotactic factor
TSG I
K-60
IL-8
protein 3-10C
chemokine (c-x-c motif) ligand VIII
K(60)
LOC567083
chromosome
scaffold
similar to interleukin 8

GO ID 0008009
0005153
0007186
0036499
0001525
0061844
0019722
0007050
0044344
0071347
0071222
0071356
0070098
0006935
0019221
0048566
0006955
0050930
0006954
0035556
0030595
0045744
0008285
0042119
0030593
0045766
0090023
0031623
0030155
2000535
0045091
0034976
0002237
0007165
0005576
0005615
0006928
0005622
0006987
0044267
0030968
0005515
0007267
0007242
0023034
0007600

KEGG ID hsa:3576

MedLine Reference 10343098
10368283
10376933
10491366
10620615
10707023
10734056
10775602
10820279
10823949
10880251
10881932
10929056
10982368
10985244
10985253
11023497
11069235
11083887
11160671
11328384
11483765
11564821
11756416
11784713
11814358
11854210
11855786
11868823
11876744
11877327
11884401
11884459
11888846
11896938
11910304
11911801
11950481
11956621
11960393
11964077
11966578
11973337
11989790
11999552
12027404
12033786
12034575
12039947
12055238
12055326
12056817
12060853
12090473
12091490
12093676
12096924
12096927
12100025
12101072
12115500
12117737
12117926
12117969
12117995
12123753
12126643
12133438
12139952
12149127
12150710
12151316
12151344
12163591
12165085
12169092
12169272
12186702
12186913
12187073
12195386
12223528
12225945
12239630
12359770
12364441
12366401
12382118
12384994
12388718
12388959
12391099
12393171
12410798
12453441
12477932
12480084
12485855
12496258
12502445
12513912
12520365
12524080
12529421
12530093
12533683
12543081
12547728
12548717
12565901
12573991
12576442
12584113
12586630
12594001
12594058
12615831
12626597
12628493
12632066
12634636
12637525
12646250
12653788
12654635
12654834
12660426
12662377
12702497
12707271
12720537
12727029
12729795
12738388
12744776
12748056
12748173
12777373
12782302
12792476
12797546
12802400
1281554
12818188
12820969
12839933
12839942
12849706
12850808
12855659
12857601
12871882
12876073
12898436
12898448
12901801
12902511
12909591
12919697
12933891
12952969
12960242
13129857
1391327
14500465
14500470
14500479
14530367
14550286
14578856
14623984
14625302
14630611
14634582
14634584
14641180
14645117
14657869
14669337
14672330
14676125
14688120
14714557
14718619
14725568
14729508
14730209
14756945
14767470
14977935
15001458
15021975
15039334
15047831
15057743
15063730
15069060
15072962
15077296
15079071
15085176
15096327
15102084
15120188
15143062
15146413
15152368
15158775
15169673
15178568
15178703
15181190
15194816
15196572
15203561
15203565
15208657
15208668
15209388
15214047
15218164
15222686
15271933
15273081
15280021
15280372
15292066
15297389
15300588
15302608
15321994
15321998
15331599
15337758
15342208
15356171
15356575
15358661
15364108
15379213
15385484
15453805
15454487
15469436
15489227
15496610
15498828
15514971
15521010
15528384
15529362
15531763
15534087
15541716
15542429
15556942
15564333
15569594
15579374
15579377
15583145
15585560
15585673
15591054
15607204
15607368
15609321
15613411
15615716
15630185
15641067
15650393
15650394
15652404
15652492
15659384
15661856
15664665
15667946
15679580
15701651
15731050
15746434
15760459
15760676
15784717
15803062
15805227
15828019
15831558
15845475
15845476
15845864
15862344
15866212
15894298
15897801
15902922
15914533
15945132
15962221
15972644
15976103
15976326
15979992
15987860
16004996
16029496
16038881
16039610
16052590
16085794
16088182
16096323
16098041
16098254
16101867
16107255
16125276
16134994
16164755
16166417
16168518
16185356
16195477
16195815
16197369
16204411
16220540
16240219
16251188
16251427
16270354
16280123
16289597
16293628
16293707
16299055
16322472
16365152
16373669
16387844
16394009
16406804
16491014
16498082
16499908
16525644
16541418
16545602
16547413
16552338
16552751
16554734
16581825
16632517
16679918
16687414
1673289
16757060
16769764
16777061
16793206
16794530
16795034
16797773
16820307
16824064
16825597
16846747
16864907
16864908
16873245
16890267
16926411
16937534
16939660
16973972
16990258
17035306
17078003
17115422
1840701
1895676
1988949
2007144
2184886
2648569
2663993
2664463
2681204
2953813
3223947
3260265
7673721
7695626
8077676
8081002
8381837
8626516
8662698
8663179
8702798
9141135
9323208
9363947
9378998
9464567
9510190
9551928
9659156
9828130
9921412
10361232
11978786
14711052
15489334
1639201
16547804
16620395
16927373
16928771
16978071
16996240
17008880
17020755
17020928
17022986
17024463
17061983
17075576
17141217
17174061
17189320
17202379
17203209
17204468
17207890
17211588
17215524
17220369
17240051
17244794
17257314
17268170
17277102
17304101
17307163
17309748
17356794
17420005
17433258
17458901
17466952
17494793
17498253
17498967
17513455
17538964
17540779
17543146
17550933
17565687
17592301
17620090
17638896
2005614
2145175
2170450
2182630
2200751
2212672
2456256
2523801
2555418
2648135
2655583
2659722
3057503
3279957
3322281
3480540
8631339
11252171
11768129
12016516
15372997
8737490
9922392

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Homo sapiens
Bos taurus
Danio rerio

OMIM ID 146930

Hugo ID 6025
HGNC:6025

Human chromosome position 4q13.3
4q13-q21

Swiss-Prot Accession A0A024RDA5
P10145
P10145.1
B2R4L8
Q6FGF6
Q6LAE6
Q96RG6
Q9C077
Q9UCE1
Q9UCR8
Q9UCR9
Q9UCS0
AAB21773
AAB23944
Q6LDS6
IL8_HUMAN

PIR ID A37034

GenBank ID NC_000004
NM_000584
NP_000575
NM_001354840
NP_001341769
NG_029889
AC112518
AF385628
AAK60276
CH471057
EAX05687
EAX05688
EAX05689
D14283
BAA03245
HC462818
CBK51144
HI519526
CBX54344
M28130
AAA59158
AJ227913
AK131067
AK311874
BAG34815
BC013615
AAH13615
BG497712
BT007067
AAP35730
CR542151
CAG46948
DA671239
M17017
AAA35611
M26383
AAA36323
Y00787
CAA68742
Z11686
CAA77745
P10145
NC_018915
AMYH02009469
DQ890564
ABM92181
DQ893727
ABM84653
M23344
AAA74722
AC_000136
ABBA01022993
NT_022778
NW_001838914
NW_922162
AC_000047
CR594973
CR595357
CR600500
CR601533
CR601902
CR603686
CR619554
CR623683
CR623827
NT_006216
M20922
AAA66353
X87888
CAA61140
AAB21773
AAB23944
Q6LDS6
AAA63206
AF123369
CAA54789
AAA52849
M31608
BAC01669
AB064041
X77737
M62731
AAM75835
119626093
119626094
123994103
124359
14326461
15488984
179580
183043
185248
185490
186368
188628
21669289
21702298
219916
247142
258901
30582973
33959
34519
49457298
535097
535769
74724764
871269
119626092
124126817
NT_086651
1699354
2829675
56405844
56549077
7158874
73587443
75053328
AAB37483
AAD02808
AAF37575
AAI03311
AAV97702
AF061521
AF232704
AF465155
AY849380
BC103310
NC_007304
NM_173925
NP_776350
NW_001495205
P79255
Q71UR4
S82598
NC_007112
NW_001512005
XM_690370
XP_695462
68354177
126002739
567083
Dr.112992
dre:567083

Swiss-Prot ID IL8_HUMAN

Cell Localization Secreted
Extracellular

Ensembl ID ENSG00000169429
ENSP00000306512.3
ENST00000307407.8
ENSP00000385908.1
ENST00000401931.1
ENSP00000306512
ENST00000307407

Unigene ID Hs.624
Hs.561078
Hs.443948
Hs.449585
Hs.551925
Hs.654584
Bt.49740
Dr.112992

Shape Rhomb

IPI ID IPI00215621
IPI00288914
IPI00816576
IPI00873454
IPI00894389

Homo sapiens Chromosome position 4q13-q21

Ensembl Transcript ID ENST00000395775
ENST00000307407

FunctionalClass chemokine
interleukin-8 receptor binding
protein binding

Bos taurus Chromosome position 6

KEGG pathway Leukocyte transendothelial migration

Ensembl Gene ID ENSG00000169429

LocatorString pmquery:prevacid, prilosec (omeprazole) 2002:2010[PDAT]
pmquery:sepsis+OR+blood+poisoning+OR+Septicemia+OR+systemic+inflammatory+response+syndrome
pmquery:curcumin prostate cancer
pmquery:egfr+transactivation