Protein IL10RB

URN urn:agi-llid:3588
Total Entities 0
Connectivity 293
Name IL10RB
Description interleukin 10 receptor subunit beta
Notes The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Primary Cell Localization Plasma membrane
Class Receptor
ObjectType Protein

Pathway AHR in Intestinal Cell Antimicrobial Barrier Maintenance
anti-Inflammatory Function of Macrophage M2 Lineage
IL22 Induces Keratinocyte Proliferation in Psoriasis
Keratinocyte Activation in Psoriatic Arthritis
Gluten Impact on Neuronal System (Hypothesis)
IL10/STAT3 Signaling in M2 Macrophage and Retinal Angiogenesis
Alveolar Macrophage Negative Regulation Declined in COPD
STAT3 and NFkB Activate Inflammation-Induced Tumorigenesis
STAT3 Inhibits Maturation of Dendritic Cells and Facilitates Cancer Progression
STAT3 Facilitates the Function of Treg Cells and Cancer Progression
Myeloid Derived Suppressor Cells in Cancer Immune Escape
IFNLR1-> STAT/NFKB Signaling
IL22R -> STAT3 Signaling
IL10R -> STAT Signaling
IL10 Expression Targets
IL22 Expression Targets
IFN signaling in alveolar cells
2_Interleukin-17 and interleukin-22 signaling in psoriasis
4_1_Polymorphisms associated with inflammatory bowel diseases
1_Inflammatory mediators increase the production of hepcidin (HAMP)
2_Defective tolerance of autoreactive T-cell in T1D
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Genes Highly-Expressed on Surface of Human Primary beta-Cell According to PMID:22460761

MedScan ID 3588

LocusLink ID 3588
16155
304091

Alias RGD1560373
D21S58
6620401D04
IL-10R subunit beta
antigen CDw210b
IL10r2
CDw210b antigen
interleukin 10 receptor, beta
cytokine receptor family II, member IV
interleukin-10 receptor subunit 2
cytokine receptor family 2 member 4
CRF2-4
interleukin IL10 receptor 2
OTTHUMP00000221101
interleukin IL-10 receptor beta
interleukin IL10R beta
interleukin IL10RB
IL10RB
interleukin IL-10R-B
PIR:G01418
CRF2 IV
RIKEN cDNA 6620401D04 gene
IL-10 receptor subunit beta
CDW210B
IL-10 receptor beta
interleukin IL10r2
D16H21S58
cytokine receptor class-II CRF2 IV
D21S66
CRFB4
interleukin-10 receptor beta subunit
D21S58h
IL-10R-B
interleukin-10 receptor subunit beta
IL10R beta
AI528744
interleukin 10 receptor 2
IL-10R subunit 2
6620401D04Rik
cytokine receptor family II, member 4
cytokine receptor class-II CRF2-4
IL-10R2
IL-10RB
cytokine receptor class-II member 4

GO ID 0004896
0004920
0038023
0019221
0051607
0006955
0006954
0046427
0007165
0016021
0032002
0005886
0016020
0007596
0070062
0004872

KEGG ID hsa:3588
rno:304091
mmu:16155

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Mus musculus
Homo sapiens
Rattus norvegicus

Mouse chromosome position 16 52.87 cM

OMIM ID 123889
610424
612567

Rat chromosome position 11q11

Hugo ID 5965
HGNC:5965

Human chromosome position 21q22.11

Swiss-Prot Accession Q08334
Q08334.2
Q8VHM7
Q3TU35
Q61190.1
D3ZM36
Q9BUU4
Q61190

PIR ID A47003

GenBank ID NC_000021
NM_000628
NP_000619
NG_012089
AP000295
AP001716
AY323826
AAP72016
CH471079
EAX09840
EAX09841
U08988
AAA86872
AI025402
AK124057
BAC85761
AK299961
BAG61787
AK313348
AU133530
BC001903
AAH01903
BT009777
AAP88779
JN591378
AEX60807
Z17227
CAA78933
Q08334
NC_000082
NM_008349
NP_032375
XM_006522924
XP_006522987
AC152503
AF440786
AAL40943
CH466602
EDL03829
EDL03830
AF440787
AAL40946
AK018347
AK040938
AK134042
BAE21991
AK137922
AK160991
BAE36136
AK177687
AK179694
AK181086
AK183290
AK195215
AK196209
AK201410
AK208585
AK213392
BC145791
AAI45792
CK788837
U53696
AAC53062
Q61190
NC_005110
XM_006248062
XP_006248124
NM_001107111
NP_001100581
XM_006248063
XP_006248125
AC_000079
AABR07033630
AABR07033631
AABR07072220
AAHX01068278
AAHX01068279
CH473989
EDM10716
EDM10717
DQ892552
AMYH02037735
XP_005261028
XP_005261027
ABM86689
AAHY01130186
AAHY01130185
AC_000038
DQ895763
AABR06067655
AABR06067654
ABM83478
AC_000153
L42243
NC_018932
XM_005260970
XM_005260971
ABBA01057337
ABBA01057336

Swiss-Prot ID I10R2_HUMAN

Cell Localization Membrane
Plasma membrane

Ensembl ID ENSG00000243646
ENSP00000290200.2
ENST00000290200.7
ENSMUSG00000022969
ENSMUSP00000023691.5
ENSMUST00000023691.11
ENSRNOG00000028638
ENSRNOP00000058062.3
ENSRNOT00000061345.3
ENSRNOT00000061345
ENST00000290200
ENST00000290200.6
ENSP00000290200
ENSRNOP00000058062
ENSMUST00000023691
ENSMUSP00000023691

MGI ID MGI:109380
109380

RGD ID 1560373

Unigene ID Hs.654593
Mm.4154
Rn.22261

Homologene ID 523