URN | urn:agi-llid:5599 |
---|---|
Total Entities | 0 |
Connectivity | 4146 |
Name | MAPK8 |
Description | mitogen-activated protein kinase 8 |
Notes | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] |
Primary Cell Localization | Cytoplasm |
Class | Protein kinase |
Pathway | Proteins Involved in Stem Cell Exhaustion in Aging |
---|---|
Osteoarthritis | |
Skin Aging | |
Fatty Acids Block TLR Signaling in Enteroendocrine Cell | |
Dopamine Receptors Signaling | |
Thrombopoietin Receptors Signaling in Platelet Maturation | |
Toll-like Receptors Act through MYD88-TIRAP Signaling | |
NOD-like Receptors | |
TLR4 Signaling in Leukocytes | |
T-Cell Positive Selection and Neglect Induced Death | |
T-Cell Central Tolerance | |
Scavenger Receptors in Platelet Activation | |
Toll-like Receptors in Sterile Inflammation | |
MC1R in anti-Inflammatory Signaling | |
Basophil Activation | |
Eosinophil Survival by Cytokine Signaling | |
Mast-Cell Activation via IgE Signaling | |
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling | |
AXL Receptor Inhibits Macrophages and Dendritic Cells Function | |
Neutrophil Recruitment and Priming | |
Negative Acute Phase Proteins Synthesis | |
Positive Acute Phase Proteins Synthesis | |
Vascular Endothelial Cell Activation by Cytokines | |
Nociception Expression Targets Signaling | |
ADRA1A -> IL6 Production | |
CNR1/2 -> IL1B/2/4/6/10 Production | |
DRD2 Expression Targets | |
PTGER2/3 -> Inflammation-Related Expression Targets | |
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons | |
Apoptosis | |
Proteins Involved in Atherosclerosis | |
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction | |
Dendritic Cells Function in Atherosclerosis | |
Dilated Cardiomyopathy | |
Proteins Involved in Dilated Cardiomyopathy | |
Proteins Involved in Hypertrophic Cardiomyopathy | |
Proteins Involved in Arterial Hypertension | |
Myocardial Remodeling | |
Myocardial Infarction | |
Proteins Involved in Myocardial Ischemia | |
Inflammatory Reaction in Acne Vulgaris | |
Mast-Cells Activation in Atopic Dermatitis | |
Proteins Involved in Melanoma | |
IL17 Signaling in Psoriasis | |
IL22 Induces Keratinocyte Proliferation in Psoriasis | |
Proteins with Altered Expression in Psoriasis | |
Dendritic Cells Function in Psoriasis | |
beta-Cell Death in Diabetes Mellitus Type 2 | |
Proteins Involved in Diabetes Mellitus Type 2 | |
Podocyte Dysfunction in Diabetic Nephropathy | |
Proteins Involved in Diabetic Nephropathy | |
Proteins Involved in Insulin Resistance | |
Insulin Resistance in Myocytes Induced by Obesity | |
Insulin Resistance in Hepatocytes | |
Proteins Involved in non-Alcoholic Fatty Liver Disease | |
beta-Cell Destruction through Cytokines in Diabetes Mellitus | |
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model) | |
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism | |
Fatty Acids in Hypertension and Atherosclerosis Development | |
Proteins Involved in Obesity | |
Macrophage Dysfunction | |
OipA Signaling in Helicobacter Pylori Infection | |
Dendritic Cell Function in Ulcerative Colitis | |
B-Cell Acute Lymphoblastic Leukemia | |
B-Cell Chronic Lymphocytic Leukemia | |
Chronic Myeloid Leukemia | |
Proteins Involved in Chronic Myeloid Leukemia | |
Follicular Lymphoma | |
Osteoclast Activation in Multiple Myeloma | |
Multiple Myeloma | |
T-Cell Acute Lymphoblastic Leukemia | |
SERPINA1 Associated Liver Damage | |
Proteins Involved in Hepatocellular Carcinoma | |
Hepatocellular Carcinoma | |
Growth Factor Signaling in Hepatocellular Carcinoma | |
Pancreatic Ductal Carcinoma | |
Growth Factor Signaling in Pancreatic Neoplasms | |
Pancreatic Neuroendocrine Tumors | |
TGFBR Signaling in Pancreatic Neoplasms | |
TSLP Signaling in Bronchial Epithelial Cell in Asthma | |
IgE Induces Airway Smooth Muscle Cell Proliferation | |
Basophil Activation in Asthma | |
Mast-Cell Activation in Asthma | |
Mucin Production in Goblet Airway Epithelial Cells | |
CFTR Facilitates Oxidative Stress in Airway Epithelium in CF | |
Airway Epithelial Cell Dysfunction | |
Osteoclast Activation in Gout | |
Monocytes Function in Gout | |
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis | |
Apoptosis of Chondrocyte | |
Dendritic Cell Dysfunction in Psoriatic Arthritis | |
Synovial Fibroblast Activation in Psoriatic Arthritis | |
Keratinocyte Activation in Psoriatic Arthritis | |
Synovial Fibroblast Proliferation in Rheumatoid Arthritis | |
Osteoclast Activation in Rheumatoid Arthritis | |
Apoptosis Block in Synovial Fibroblast | |
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis | |
Proteins Involved in Rheumatoid Arthritis | |
Skin Fibrosis | |
CCR5 Signaling in Macrophages | |
Apoptosis Block in Infected Cells | |
TNF Receptor Associated Periodic Syndrome | |
Cryopyrin (NLPR3) Associated Periodic Syndromes | |
Majeed Syndrome | |
ER Stress in Huntington Disease | |
Proteins Involved in Huntington Disease | |
IL6 and Insulin Resistance in Muscular Dystrophies | |
IL6 Overexpression After Contraction in Skeletal Muscles in Muscular Dystrophies | |
Muscular Dystrophies | |
Dystrophin Glycoprotein Complex Signaling in Muscular Dystrophies | |
Osteoclast Activation in Postmenopause | |
Proteins Involved in Alzheimer's Disease | |
Glioma Invasion Signaling | |
Proteins Involved in Glioma | |
Growth Factor Signaling in Neuroblastoma | |
Neuroblastoma | |
Proteins Involved in Parkinson's Disease | |
Proteins Involved in Breast Cancer Related to WNT Signaling Pathway | |
Proteins Involved in Breast Cancer Related to ESR1 Signaling Pathway | |
WNT Signaling in Breast Cancer | |
ESR1/ERBB Positive Luminal Breast Cancer | |
ESR1 Signaling in Breast Cancer | |
Endometrial Cancer | |
Endometrioid Endometrial Cancer | |
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer | |
Proteins Involved in Endometriosis | |
Angiogenesis in Endometriosis | |
Proteins Involved in High-Grade Serous Ovarian Carcinoma | |
Endometrioid Ovarian Carcinoma | |
Proteins Involved in Endometrioid Ovarian Carcinoma | |
Clear Cell Ovarian Carcinoma | |
Proteins Involved in Mucinous Ovarian Carcinoma | |
High-Grade Serous Ovarian Carcinoma | |
Low-Grade Serous Ovarian Carcinoma | |
Proteins Involved in Low-Grade Serous Ovarian Carcinoma | |
Ovarian Cancer | |
Proteins Involved in Clear Cell Ovarian Carcinoma | |
Mucinous Ovarian Carcinoma | |
Subepithelial Fibroblasts in Middle Ear Cholesteatoma | |
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes | |
Androgen Receptor/Akt Signaling | |
RNase L Signaling in Prostate Cancer | |
Proteins Involved in Age-Related Macular Degeneration | |
ER Stress in Macular Degeneration | |
Steroids Induced Cataract | |
MYOC Associated Glaucoma | |
Proteins Involved in Noise-Induced Hearing Loss | |
Aminoglycosides and Cisplatin Induced Ototoxicity (Mouse Model) | |
Proteins Involved in Hearing Loss | |
Proteins Involved in Otitis Media | |
Cytokines Trigger Otitis Media | |
Immune System Role in Otitis Media | |
Alveolar Macrophage Negative Regulation Declined in COPD | |
Alveolar Macrophages Dysfunction in COPD | |
Proteins Involved in Chronic Obstructive Pulmonary Disease | |
T-Cell Cytotoxic Activation | |
Mucin Hyperproduction in Goblet and Mucous Cells | |
WNT Signaling in Cystic Kidney Disease | |
Polycystins Mutation Effects in Cystic Kidney Disease | |
Proteins Involved in Polycystic Kidney Disease | |
Proteins Involved in Glomerulonephritis | |
Podocyte Dysfunction in Glomerulonephritis | |
Apoptosis of Renal Tubule Epithelial Cell in Pyelonephritis | |
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets | |
AREG -> AP-1 Expression Targets | |
Dopamine/Gi Expression Targets | |
BTC -> AP-1/ATF/CREB Expression Targets | |
Frizzled Receptors -> ARRB1/ARRB2 non-Canonical Signaling | |
Complement Component GPCRs Signaling | |
EGF -> AP-1/ATF Expression Targets | |
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets | |
EGF -> TP53 Expression Targets | |
EGFR/ERBB2 -> TP53 Signaling | |
EGFR -> AP-1/ATF2 Signaling | |
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling | |
EREG -> AP-1/ATF Expression Targets | |
Erythropoietin -> AP-1/MYC/CREB Expression Targets | |
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets | |
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets | |
FGF9 -> AP-1/CREB/MYC Expression Targets | |
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets | |
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets | |
FGF8 -> AP-1/CREB/MYC Expression Targets | |
FGF18 -> AP-1/CREB Expression Targets | |
FGF4 -> AP-1/MYC Expression Targets | |
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets | |
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets | |
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling | |
FrizzledR -> JUN/PAX2 Signaling | |
HBEGF -> AP-1/ATF Expression Targets | |
HBEGF -> TP53 Expression Targets | |
HBEGF -> CREB/MYC Expression Targets | |
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets | |
HGFR -> AP-1/CREB/MYC Signaling | |
RAS/RAF/MAPK Signaling Activation in Cancer | |
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors | |
Apoptosis Block by Death Receptor Signaling in Cancer | |
Apoptosis Evasion in Cancer: Overview | |
Apoptosis Block by BCL2 Family Proteins in Cancer | |
VEGFA Dependent Angiogenesis in Cancer | |
Inhibition of THBS1 Activates Angiogenesis in Cancer | |
VEGF Independent Angiogenesis in Cancer | |
Hyaluronic Acid, CD44 and HMMR in Cancer Cell Invasion and Survival | |
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling | |
CTGF -> AP-1/CREB/MYC Expression Targets | |
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets | |
Dronabinol/Anandamide Expression Targets | |
S1P Expression Targets | |
GPCRs Family -> Expression Targets in Lymphoid System and Blood | |
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets | |
NRG1 -> TP53 Expression Target | |
NRG1 -> AP-1/ATF Expression Targets | |
NGF -> SMAD3/NF-kB Expression Targets | |
NGF -> AP-1/TP53/MYC Expression Targets | |
BDNF Expression Targets | |
NTF3 Expression Targets | |
NTF4 Expression Targets | |
NOTCH -> TCF3 Signaling | |
NOTCH Expression Targets | |
PDGFB -> AP-1/CREB/MYC Expression Target | |
PDGFD -> AP-1 Expression Targets | |
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets | |
PDGFR -> AP-1/MYC Signaling | |
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets | |
GNRH1 Expression Targets | |
GNRH2 Expression Targets | |
EDN1 Expression Targets | |
EDN3 Expression Targets | |
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets | |
AngiopoietinR -> AP-1 Signaling | |
GDNF -> HSF1 Signaling | |
EphrinB -> MAPK/JUN/FOS Signaling | |
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling | |
GAS6 -> AP-1/CREB Expression Targets | |
FIGF -> AP-1 Expression Target | |
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets | |
GDNF -> HSF1 Expression Targets | |
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets | |
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets | |
FLT3LG -> AP-1/CREB/CREBBP Expression Targets | |
TGFBR -> AP-1 Signaling | |
TNF-alpha/TNFRSF1A Signaling | |
JNK/MAPK Signaling | |
AXL Receptor Tyrosine Kinase Signaling | |
VEGF Signaling | |
EGFR Signaling | |
WNT Planar Cell Polarity (PCP) non-Canonical Signaling | |
HRAS Signaling | |
TGFA -> TP53 Expression Targets | |
TGFA/AP-1/ATF Expression Targets | |
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
TGFB3-TGFBR2 Expression Targets | |
TGFB2-TGFBR2 Expression Targets | |
TGFB1-TGFBR2 Expression Targets | |
FASLG Expression Targets | |
TNFSF10 Expression Targets | |
LTA Expression Targets | |
TNFSF14 Expression Targets | |
TNF -> AP-1 Expression Targets | |
CD72 -> AP-1 Expression Targets | |
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets | |
TNFSF13 Expression Targets | |
TNFSF13B Expression Targets | |
TNF -> ELK-SRF Expression Targets | |
TNF -> TP53/ATF Expression Targets | |
EDA Expression Targets | |
EctodysplasinR -> AP-1 Signaling | |
TNFR -> CREB/ELK-SRF Signaling | |
TNFR -> AP-1/ATF/TP53 Signaling | |
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling | |
TNFRSF6 -> DDIT3 Signaling | |
TNFRSF6 -> HSF1 Signaling | |
TNFRSF1A -> AP-1/ATF/TP53 Signaling | |
TNFRSF1A -> CREB/ELK-SRF Signaling | |
Thrombopoietin -> SPI1 Expression Targets | |
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets | |
TLR4 -> AP-1 Expression Targets | |
TLR5 Expression Targets | |
TLR7 Expression Targets | |
TLR4 -> AP-1/EGR1/HIF1A Expression Targets | |
IL1B -> PGE2 Expression Targets | |
TLR1 -> 2/6 Expression Targets | |
TLR9 Expression Targets | |
TLR -> AP-1 Signaling | |
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy | |
VEGFA -> AP-1/CREBBP/MYC Expression Targets | |
VEGFR -> AP-1/CREB/MYC Signaling | |
WNT1 Expression Targets | |
WNT3A Expression Targets | |
WNT4 Expression Targets | |
WNT5A Expression Targets | |
WNT7A Expression Targets | |
1_Inflammation in keratinocytes in the pathology of acne | |
2_Acute phase initiation in atopic dermatitis | |
2_Interleukin-17 and interleukin-22 signaling in psoriasis | |
1_TNF and IL1B provoke ECM degradation in osteoarthritis | |
1_Osteoclast-mediated bone resorption in postmenopausal women | |
1_Formation of cysts in polycystic kidney disease | |
2_Podocyte dysfunction in glomerulonephritis | |
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS | |
2_MYOC-associated glaucoma | |
3_Endoplasmic reticulum stress in age-related macular degeneration | |
2_Pathogens stimulate mucins expression in the middle ear | |
2_Cigarette smoke and inflammation cause alveolar epithelial cell death in COPD | |
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD | |
2_Intestine epithelial cells drive immunological responses in ulcerative colitis | |
2_Lipotoxicity in NAFLD | |
6_p12I Viral protein promotes T-cell activation in HTLV-1 infection | |
4_2_Insulin resistance: inflammation-related insulin resistance | |
4_3_Insulin resistance: FFA-related insulin resistance | |
2_SERPINA1-associated liver damage | |
2_Neuron and Schwann cell death | |
HRAS->RAF->MAPK1/3 | |
mapk1 protein modificators | |
Interleukin-17 and interleukin-22 signaling in psoriasis |
Group | Genes with Mutations Associated with Ageing (non-Mammalian Animal Model) |
---|
Source | GO component |
---|---|
ResNet | |
curated |
MedScan ID | 5599 |
---|
LocusLink ID | 5599 |
---|---|
26419 | |
116554 | |
71973 | |
539941 | |
19098 | |
105560 | |
445436 | |
326419 | |
65236 | |
50656 | |
102478 |
Alias | OTTMUSP00000019791 |
---|---|
c-Jun N-terminal kinase 1 | |
SAPK1/JNK | |
p46JNK1 | |
OTTHUMP00000019558 | |
p54 gamma | |
OTTHUMP00000019556 | |
MAP kinase 8 | |
stress-activated protein kinase JNK I | |
mitogen-activated protein kinase 8 isoform JNK1 beta2 | |
Jun NH2-terminal kinase I | |
AI849689 | |
protein kinase JNK1 | |
protein kinase JNK I | |
stress-activated protein kinase JNK1 | |
JNK1A2 | |
stress-activated protein kinase 1 | |
JNK21B1/2 | |
OTTHUMP00000019552 | |
JNK1 beta protein kinase | |
mitogen activated protein kinase 8 | |
SAPK I | |
SAPK1 | |
JNK I | |
Jun NH2-terminal kinase 1 | |
JNK1 | |
stress-activated protein kinase 1c | |
PRKM8 | |
OTTMUSP00000019794 | |
JNK1 alpha2 protein kinase | |
mitogen-activated protein kinase 8 isoform JNK1 alpha1 | |
cJun N-terminal kinase 1 | |
c-Jun NH2-kinase 1 | |
c-Jun NH2-terminal kinase 1 | |
PIR:A53063 | |
OTTMUSP00000019790 | |
mitogen activated protein kinase VIII | |
SAPK gamma | |
OTTMUSP00000019793 | |
OTTHUMP00000019555 | |
JNK1 beta1 protein kinase | |
c-Jun NH2-terminal kinase I | |
protein kinase mitogen-activated 8 | |
MAPK8 | |
JNK-46 | |
protein kinase mitogen-activated VIII | |
SAPK1/c-Jun N-terminal kinase | |
JNK1 alpha protein kinase | |
SAPK1c | |
stress activated protein kinase 1 | |
c-Jun N-terminal kinase I | |
JNK | |
JUN N-terminal kinase | |
mitogen-activated protein kinase 8 | |
MAPK 8 | |
c-jun NH2-terminal kinase | |
Jun NH2-terminal kinase | |
c-Jun N-terminal kinase | |
c-Jun NH2-kinase | |
cJun N-terminal kinase | |
Stress-activated protein kinase JNK1 | |
Stress-activated protein kinase JNK I | |
RBPMS2 | |
JNK1alpha2 | |
expressed sequence AI849689 | |
RBPMS2s | |
JNK1-alpha-1 | |
RNA-binding protein with multiple splicing II | |
similar to RIKEN cDNA 2400008B06 | |
expressed sequence ai316523 | |
Pristane induced arthritis QTL 1 | |
Pristane induced arthritis QTL I | |
mitogen-activated protein kinase 8 transcript variant II | |
Pia I | |
mitogen-activated protein kinase 8 transcript variant 2 | |
Pia1 | |
RNA-binding protein with multiple splicing 2 | |
scaffold | |
chromosome | |
zgc:112379 |
EC Number | 2.7.11.24 |
---|---|
2.7.1.- | |
2.7.11.1 | |
2.7.1.37 |
GO ID | 0005524 |
---|---|
0004705 | |
0004707 | |
0019899 | |
0042826 | |
0035033 | |
0016301 | |
0004674 | |
0038095 | |
0007254 | |
0007258 | |
0034198 | |
0071276 | |
0071345 | |
0071222 | |
0071260 | |
0071310 | |
0034614 | |
0035556 | |
0043066 | |
0032091 | |
0048666 | |
0018105 | |
0018107 | |
0043065 | |
0031281 | |
0090045 | |
0010628 | |
1900740 | |
0051247 | |
0006468 | |
1902595 | |
0051090 | |
0042752 | |
0010468 | |
0031063 | |
0016241 | |
0032880 | |
0009411 | |
0009612 | |
0048511 | |
0051403 | |
0030424 | |
0097441 | |
0005737 | |
0005829 | |
0005739 | |
0043005 | |
0005654 | |
0005634 | |
0019894 | |
0000166 | |
0004672 | |
0004712 | |
0016740 | |
0070301 | |
0071732 | |
0048813 | |
0048263 | |
0006954 | |
0001764 | |
0031175 | |
0097150 | |
0001503 | |
0016310 | |
0045740 | |
2001235 | |
0010666 | |
0030335 | |
2000017 | |
0034352 | |
0031116 | |
0002052 | |
0043525 | |
2001224 | |
0071803 | |
0031398 | |
1901485 | |
0097300 | |
0061833 | |
0046605 | |
0045664 | |
0006355 | |
0046686 | |
0009408 | |
0042542 | |
0006970 | |
0007165 | |
0097050 | |
0032839 | |
0043204 | |
0002102 | |
0031982 | |
0000165 | |
1904646 | |
0071347 | |
0034349 | |
0048545 | |
0006950 | |
0071216 | |
0005622 | |
0002755 | |
0002756 | |
0035666 | |
0006915 | |
0097190 | |
0045087 | |
0097193 | |
0048011 | |
0034166 | |
0034134 | |
0034138 | |
0034142 | |
0034146 | |
0034162 | |
0038123 | |
0038124 | |
0002224 | |
0016772 | |
0008063 | |
0008633 | |
0034130 | |
0023014 | |
0033267 | |
0008624 | |
0008629 | |
0031558 | |
0008152 | |
0005515 | |
0006928 | |
0046933 | |
0004682 | |
0050775 | |
0016469 | |
0004713 | |
0046961 | |
0004691 | |
0015986 | |
0003723 | |
0003676 |
KEGG ID | hsa:5599 |
---|---|
mmu:26419 | |
rno:116554 |
Organism | Homo sapiens {Organism urn:agi-taxid:9606} |
---|---|
Mus musculus {Organism urn:agi-taxid:10090} | |
Rattus norvegicus {Organism urn:agi-taxid:10116} | |
Homo sapiens | |
Mus musculus | |
Rattus norvegicus | |
Danio rerio | |
Bos taurus | |
Human |
Mouse chromosome position | 14 |
---|---|
14 B |
OMIM ID | 601158 |
---|---|
OMIM:601158 | |
61411 |
Rat chromosome position | 16p16 |
---|
Hugo ID | 6881 |
---|---|
HGNC:6881 |
Human chromosome position | 10q11.22 |
---|
PIR ID | S71097 |
---|---|
S71099 | |
S43970 |
Swiss-Prot ID | MK08_HUMAN |
---|---|
MK08_MOUSE | |
MK08_RAT | |
Q544A0_MOUSE | |
A1L4K2_HUMAN | |
B5BTZ5_HUMAN | |
B7ZLV4_HUMAN | |
D3DX92_HUMAN | |
D3DX88_HUMAN |
Cell Localization | Cytoplasm |
---|---|
Nucleus | |
Extracellular |
Ensembl ID | ENSG00000107643 |
---|---|
ENSP00000378974.4 | |
ENST00000395611.7 | |
ENSP00000353483.4 | |
ENST00000360332.7 | |
ENSP00000363297.3 | |
ENST00000374182.7 | |
ENSP00000363304.1 | |
ENST00000374189.5 | |
ENSP00000363294.3 | |
ENST00000374179.8 | |
ENSMUSG00000021936 | |
ENSMUSP00000107574.1 | |
ENSMUST00000111943.7 | |
ENSMUSP00000022504.5 | |
ENSMUST00000022504.11 | |
ENSMUSP00000107575.3 | |
ENSMUST00000111944.9 | |
ENSMUSP00000107576.2 | |
ENSMUST00000111945.8 | |
ENSRNOG00000020155 | |
ENSRNOP00000062048.3 | |
ENSRNOT00000065216.3 | |
ENSP00000378974 | |
ENST00000395611 | |
ENSP00000353483 | |
ENST00000360332 | |
ENSP00000363294 | |
ENST00000374179 | |
ENSP00000363304 | |
ENST00000374189 | |
ENSMUSP00000107576 | |
ENSMUST00000111945 | |
ENSMUSP00000022504 | |
ENSMUST00000022504 | |
ENSMUSP00000107575 | |
ENSMUST00000111944 | |
ENSMUSP00000107574 | |
ENSMUST00000111943 | |
ENSRNOP00000062048 | |
ENSRNOT00000065216 | |
ENSP00000363297 | |
ENST00000374182 | |
ENSP00000363291 | |
ENST00000374176 |
MGI ID | MGI:1346861 |
---|---|
1346861 | |
1328367 | |
2143015 | |
2145699 |
RGD ID | 621506 |
---|---|
61411 |
Unigene ID | Hs.138211 |
---|---|
Hs.522924 | |
Mm.21495 | |
Rn.4090 | |
Rn.160441 | |
Mm.441782 | |
Hs.445864 | |
Bt.14050 | |
Hs.267445 | |
Dr.82505 |
Homologene ID | 56760 |
---|
Shape | Sickle-vertex |
---|
IPI ID | IPI00129682 |
---|---|
IPI00191803 | |
IPI00003145 | |
IPI00024672 | |
IPI00220305 | |
IPI00220306 | |
IPI00854859 | |
IPI00646929 | |
IPI00639865 | |
IPI00857698 | |
IPI00775848 | |
IPI00775931 | |
IPI00775897 | |
IPI00776030 | |
IPI00764183 |
Chromosome position | 14 B |
---|---|
9 C | |
16p16 | |
10q11.22 |
Microarray ID | 104047_at |
---|---|
100391_at | |
A_52_P559044 | |
A_65_P05523 | |
56901_at | |
84382_at | |
H3066H10-3 | |
A_14_P122151 | |
A_43_P15745 | |
2070_i_at | |
rc_AI029013_at | |
A_51_P422342 | |
AK047936 | |
A_65_P05437 | |
2071_s_at | |
L27129_at | |
A_23_P356152 | |
136576_r_at | |
702 | |
L26318 | |
R637 | |
1420932_at | |
229664_at | |
OH7871 | |
A_23_P202540 | |
I_932382 | |
226046_at | |
NM_016700 | |
NM_002750.2 | |
L27129.1 | |
A_14_P128899 | |
34006_s_at | |
210671_x_at | |
U35005_s_at | |
1437045_at | |
A_24_P286898 | |
1420931_at | |
A_51_P357182 | |
A_52_P657817 | |
170626_i_at | |
226048_at | |
132248_r_at | |
210477_x_at | |
A_14_P107815 |
Homo sapiens Chromosome position | 10q11.22 |
---|
Ensembl Transcript ID | ENST00000374176 |
---|---|
ENST00000374182 | |
ENST00000374179 | |
ENST00000374189 | |
ENST00000360332 |
ENSEMBL | ENSG00000107643 |
---|
FunctionalClass | protein kinase |
---|---|
MAP kinase | |
hydrogen-transporting ATP synthase activity, rotational mechanism | |
nucleotide binding | |
hydrogen ion transporting ATPase activity, rotational mechanism | |
kinase | |
protein binding | |
protein-tyrosine kinase | |
protein kinase CK2 | |
JUN kinase | |
hydrogen ion transporting ATP synthase activity, rotational mechanism | |
protein serine/threonine kinase | |
transferase | |
hydrogen-transporting ATPase activity, rotational mechanism | |
ATP binding | |
cAMP-dependent protein kinase | |
RNA binding | |
nucleic acid binding |
Hugo Symbol | MAPK8 |
---|
Bos taurus Chromosome position | 28 |
---|
Mus musculus Chromosome position | 14 B |
---|---|
9 | |
14 |
KEGG pathway | Insulin signaling pathway |
---|---|
Type II diabetes mellitus | |
Focal adhesion | |
Wnt signaling pathway | |
Toll-like receptor signaling pathway | |
Colorectal cancer | |
Pancreatic cancer | |
MAPK signaling pathway | |
ErbB signaling pathway | |
GnRH signaling pathway | |
Fc epsilon RI signaling pathway | |
Adipocytokine signaling pathway |
State | isoform 4 |
---|---|
isoform 3 | |
isoform 2 | |
isoform 1 | |
p |
Rattus norvegicus Chromosome position | 16p16 |
---|
Ensembl Gene ID | ENSG00000107643 |
---|
Keyword | map kinase |
---|---|
RNA | |
map kinase kinase | |
nuclei | |
ERK activator kinase | |
PKC | |
phosphotransferase | |
SAP kinase | |
protein phosphatase | |
nucleus | |
synaptosome | |
map kinases |
ProteinAtlas NormalTissue | Tissue: adrenal gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain |
---|---|
Tissue: appendix; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: appendix; Cell type: lymphoid tissue; Level: Negative; Expression type: Staining; Reliability: Uncertain | |
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: breast; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain | |
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: cerebellum; Cell type: cells in granular layer; Level: Negative; Expression type: Staining; Reliability: Uncertain | |
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: cerebellum; Cell type: Purkinje cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain | |
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: cervix, uterine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain | |
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: colon; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain | |
Tissue: duodenum; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: epididymis; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: fallopian tube; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: gall bladder; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: heart muscle; Cell type: myocytes; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: hippocampus; Cell type: glial cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: hippocampus; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: kidney; Cell type: cells in glomeruli; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: kidney; Cell type: cells in tubules; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain | |
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: liver; Cell type: bile duct cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: liver; Cell type: hepatocytes; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: lung; Cell type: macrophages; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: lymph node; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: lymph node; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Negative; Expression type: Staining; Reliability: Uncertain | |
Tissue: ovary; Cell type: ovarian stroma cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: pancreas; Cell type: islets of Langerhans; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: parathyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: placenta; Cell type: trophoblastic cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: prostate; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: rectum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Uncertain | |
Tissue: salivary gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: seminal vesicle; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: skeletal muscle; Cell type: myocytes; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: small intestine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: spleen; Cell type: cells in red pulp; Level: Negative; Expression type: Staining; Reliability: Uncertain | |
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: stomach, lower; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: stomach, upper; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: thyroid gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: tonsil; Cell type: germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: tonsil; Cell type: non-germinal center cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: urinary bladder; Cell type: urothelial cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Weak; Expression type: Staining; Reliability: Uncertain | |
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain | |
Tissue: vagina; Cell type: squamous epithelial cells; Level: Strong; Expression type: Staining; Reliability: Uncertain | |
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Uncertain |
LocatorString | pmquery:curcumin+prostate+cancer |
---|---|
pmquery:curcumin prostate cancer | |
gscquery:curcumin+prostate+cancer |
State Description | Transcript Variant: This variant (1) is also known as JNK1 alpha1. It encodes the longest isoform (1). |
---|---|
Transcript Variant: This variant (2) is also known as JNK1 alpha2. It contains extra 5 nt within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (2) thus contains a distinct and shorter C-te... | |
Transcript Variant: This variant (3) is also known as JNK1 beta 1. It contains a different segment, and extra 5 nt within the coding region, when compared to variant 1. The extra 5 nt leads to a translation frameshift, and results in an isoform (1) tha... | |
Transcript Variant: This variant (4) is also known as JNK1 beta2. It contains a different segment within the coding region when compared to variant 1. The translation remains in-frame, and results in an isoform (4) that contains a different internal se... |