Protein MAP2K2

URN urn:agi-llid:5605
Total Entities 0
Connectivity 875
Name MAP2K2
Description mitogen-activated protein kinase kinase 2
Notes The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Primary Cell Localization Cytoplasm
Class Protein kinase

Pathway Osteoarthritis
Skin Aging
Melatonin Effects on Circadian Cycle
High Fat Diet Activates cAMP Related Exocytosis in Synapse and Endocrine Cell
Leptin and CCK8 Activate Nodose Ganglia Neuron
Insulin Influence on Protein Synthesis
Insulin Synthesis in beta-Cell
Dopamine Receptors Signaling
Serotonin Receptors Signaling
Thyroid Hormones Common non-Genomic Effects in Hyperthyroidism
Norepinephrine Release Regulation
CRH Secretion Regulation
Insulin Signaling
Prolactin Production
POMC Secretion in adenohypophysis
Mineralcorticoids Secretion Regulation
T-Cell Dependent B-Cell Activation
T-Cell Independent B-Cell Activation
Natural Killer Cell Activation through C-Type Lectin-like Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
T-Cell Maturation (Hypothesis)
Natural Killer Cell Activation
CD8+ T-Cell Activation
Th1-Cell Differentiation
Treg-Cell Differentiation
Th2-Cell Differentiation
T-Cell Receptor Signaling
CXC Chemokine Receptor Signaling
CC Chemokine Receptor Signaling
Plasmin Effects in Inflammation
Platelet Activation via Adhesion Molecules
Proplatelet Maturation
Platelet Activation via GPCR Signaling
Toll-like Receptor Independent Sterile Inflammation
Lipoxin A4/FPR2-Related Neutrophil Depression
Hypothalamic-Pituitary-Adrenal Axis in Acute Phase Response
MC1R in anti-Inflammatory Signaling
Eicosanoids in Myeloid Cell Activation
Leukotriene Effect on Airway Smooth Muscle Response
Neutrophil Activation via LTB4/Polyisoprenyl Phosphate Signaling
Eosinophil Survival by Cytokine Signaling
Eosinophil Activation
Mast-Cell Activation without Degranulation through CYSLTR1/CYSLTR2 Signaling
Mast-Cells De Novo Synthesized Mediators via IgE Independent Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
Macrophage M2-Related Phagocytosis
anti-Inflammatory Function of Macrophage M2 Lineage
Neutrophil Recruitment and Priming
Neutrophil Activation via FCGR3B
Neutrophil Degranulation via FPR1 Signaling
Neutrophil Chemotaxis
Neutrophil Activation via Adherence on Endothelial Cells
Negative Acute Phase Proteins Synthesis
Positive Acute Phase Proteins Synthesis
Vascular Smooth Muscle Cell/Pericyte Migration and Proliferation
Vascular Endothelial Cell Activation by Blood Coagulation Factors
Vascular Endothelial Cell Activation by Growth Factors
Potassium Flux Regulation
Nociception Expression Targets Signaling
Vascular Motility
NPY1R -> CRH/POMC Production
NTSR1 Expression Targets
EDNRA/B -> Vascular Motility
ADRA1 -> Vasoconstriction
ADRA1A -> IL6 Production
ADRA2C/ADRB2 -> Vasoconstriction
ADRA2C/ADRB2 -> Synaptic Endocytosis
ADRB1 -> Prostaglandin Generation
ADRA1 -> Prostaglandin Generation
BDKRB1/2 -> Prostaglandin Generation
CNR1/2 -> IL1B/2/4/6/10 Production
DRD2 Expression Targets
DRD1/5 Expression Targets
GALR1/2/3 -> POMC/NPY Production
HRH2/4 -> IL6/10 Production
CHRM1 -> IL2 Production
CHRM1/2/3 -> Vascular Motility
OPRK -> Pain Perception
PTGIR -> IL6 Production
PTGER1/4 -> Vascular Motility
PTGER2/3 -> Inflammation-Related Expression Targets
HTR1 -> IL6 Production
HTR7 -> IL6 Production
HTR5 -> TNF Production
HTR4/6/7 -> Cation Channels
IL6 Expression Targets -> Nociception
IL1B Expression Targets -> Nociception
CHRNA7 -> NOS1 Production
GABA(B)R -> Postsynaptic Inhibition
NMDA Receptors -> Ca2+/CREB Activation/PGE2 Synthesis
P2RY11/13/14 -> IL8/10 Production
Luteinizing Hormone in Oocyte Meiotic Resumption
Melatonin in Cell Survival and Antioxidant Response
Circadian Clock Genes in Suprachiasmatic Nuclei Neurons
Vitamine D Deficite and Dentin Formation
non-Genomic Rapid Actions of Vitamin D in Vitamin D Biology
Scavenger Receptor OLR1 in Inflammation Related Endothelial Dysfunction
RAGE/AGER and S100 Proteins in Cardiovascular Injury
Th1-Cells Activation and Proliferation in Atherosclerosis
Cardiomyocyte Hypertrophy
Hypertrophic Cardiomyopathy
Endothelin Signaling in Arterial Hypertension
Arterial Hypertension
Aldosterone Synthesis Acute Regulation
Endothelial Cell Dysfunction in Arterial Hypertension
Aldosterone Synthesis Chronic Regulation
Smooth Muscle Cell Dysfunction in Arterial Hypertension
TRPM4/6/7/8 Signaling in Arterial Hypertension (Hypothesis)
Smooth Muscle Cell Dysfunction in Pulmonary Hypertension
Myocardial Remodeling
Contraction Due Vasospasm
Sebocyte Proliferation in Acne Vulgaris
Inflammatory Reaction in Acne Vulgaris
Keratinocyte Proliferation in Acne Vulgaris
Hair Follicle Keratinocyte Apoptosis
Atopic Dermatitis Onset
Mast-Cells Activation in Atopic Dermatitis
Cell Cycle Dysregulation in Melanoma
Melanoma
Apoptosis Block in Melanoma Cell
MITF as a Regulator of Melanoma Cell Development
IL17 Signaling in Psoriasis
IL22 Induces Keratinocyte Proliferation in Psoriasis
Th0-Cell Aberrant Activation in Systemic Lupus Erythematosus
Th1-Cell Function in Systemic Lupus Erythematosus
B-Cell Activation in Systemic Lupus Erythematosus
Th2-Cell Function in Systemic Lupus Erythematosus
Acute Cytotoxic CD8+T-Cell Response against Melanocytes
Vitiligo
T-Cell Cytotoxic Response against Melanocytes in Vitiligo
Apoptosis of Melanocyte in Vitiligo
Humoral Immunity in Vitiligo
CD8+ T-Cell Response to Self-Determinants in Diabetes
Treg-Cell Function in Diabetes Mellitus Type 1
Natural Killer T-Cell Roles in Diabetes Mellitus Type 1
non-Suppressive Treg-Cell in Diabetes Mellitus Type 1
TLR2 Signaling in Treg-Cell in Type 1 Diabetes (Animal Model)
Natural Killer Cell in Diabetes Mellitus Type 1
Toll-like Receptors in beta-Cell
Peripheral Tolerance to Autoantigens Recession in Diabetes Mellitus Type 1
Treg-Cell Activation in Diabetes Mellitus
Donohue Syndrome Progression (Hypothesis)
Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Protein Kinase C in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy
Tubular Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Progressive Diabetic Nephropathy
Endothelial Cell Dysfunction in Early Diabetic Nephropathy
Mesangial Cell Dysfunction in Diabetic Nephropathy
Microangiopathy in Diabetic Neuropathy
Proliferative Diabetic Retinopathy
AGE Related Insulin Resistance in Skeletal Muscles
Adiponectin Synthesis Declines in Insulin Resistance
Hepatic Stellate Cells in non-Alcoholic Fatty Liver Disease
beta-Cell Destruction through Cytokines in Diabetes Mellitus
FOXO1 and SREBP-1C Role in beta-Cell Suppression (Rodent Model)
Hyperparathyroidism, Neonatal Severe
RET1 Mutation in Hyperparathyroidism
Hypothyrodism Associated Hyperprolactinemia
DRD2 Pharmacological Inhibition in Hyperprolactinemia
Ethanol Induced Efects in Hyperprolactinemia
Bone Remodeling in Hyperthyroidism
Cardiovascular Effects in Hyperthyroidism
Thyroid Dysfunction
GNRH Signaling Impairment in Hypogonadotrophic Hypogonadism
Hypoparathyroidism, Primary
Thyroid Stimulating Hormone (TSH) Resistance in Congenital Hypothyroidism
Overt Hypothyroidism, Primary
Thyroid Stimulating Hormone (TSH) Secretion in Overt Hypothyroidism
Prolactinoma Overiew
CD4+T-Cell Response in Celiac Disease
CD8+ T-Cell Response in Celiac Disease
Celiac Disease
Metastatic Colorectal Cancer
OipA Signaling in Helicobacter Pylori Infection
CagA Phosphorylation Dependent Signaling
EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Th2-Cell Function in Ulcerative Colitis
T-Cell Cytotoxic Response in Ulcerative Colitis
FLT3/KIT/MLL Signaling in Leukemia
Acute Myeloid Leukemia
Myeloid Cell Differentiation Block in Leukemia
B-Cell Acute Lymphoblastic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Follicular Lymphoma
Hodgkin Lymphoma
Osteoclast Activation in Multiple Myeloma
IL6/IGF1/VEGFA Signaling in Multiple Myeloma
Multiple Myeloma
T-Cell Acute Lymphoblastic Leukemia
Hepatocellular Carcinoma
Growth Factor Signaling in Hepatocellular Carcinoma
Pancreatic Ductal Carcinoma
Growth Factor Signaling in Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumors
TRPM7/8 in Pancreatic Adenocarcinoma
TGFBR Signaling in Pancreatic Neoplasms
Eosinophil Survival in Asthma
Il17 Signaling Related Neutrophilia in Asthma
Eosinophil Activation and Degranulation in Asthma
IL17F Signaling in Bronchial Epithelial Cell in Asthma
Airway Smooth Muscle Cell High Rate Proliferation
IgE Induces Airway Smooth Muscle Cell Proliferation
Goblet-Cell Related Mucus Secretion in Asthma
Neutrophil Degranulation via FPR1/IL8
Antigen-Presenting Cell Role in Asthma
Th2-Cell Response in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Osteoclast Activation in Gout
TNF and IL1B Induce Metalloproteinase Synthesis in Osteoarthritis
IL1B Induced Arthralgia
Steroidogenesis Impairement in Polycystic Ovary Syndrome
Ovulation Block
Polycystic Ovary Syndrome
FSH Action in Polycystic Ovary Syndrome
Keratinocyte Activation in Psoriatic Arthritis
PTPN22 Role in Rheumatoid Arthritis
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
B-Cells Function in Systemic Scleroderma
Th2-Cells Function in Systemic Scleroderma
Skin Fibrosis
WHIM Syndrome
Dentin Formation Disruption
CCR5 Signaling in Macrophages
CD8+ T-Cell Action Impairment in HIV Type 1 Infection
CD4+ T-Cell Function Decline in HIV
CD4+ T-Cell Death in HIV
Estrogen Effects on Pregnancy Gingivitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
Cowden Syndrome
Gluten Impact on Neuronal System (Hypothesis)
Osteoblast Function Decline in Osteoporosis
Osteoclast Activation in Postmenopause
BDNF Upregulation Triggered by Seizures
Apoptosis and Immediate Early Gene Activation in Epileptiform Disorders
Glioblastoma, Primary
Glioblastoma, Secondary
Astrocytoma
Growth Factor Signaling in Neuroblastoma
Neuroblastoma
ALK Associated Neuroblastoma
ERBB/VEGFR/Akt Signaling in Breast Cancer
IGF1R/AKT Signaling in Breast Cancer
ESR1/ERBB Positive Luminal Breast Cancer
Breast Cancer
ESR1 Signaling in Breast Cancer
Endometrial Cancer
Endometrioid Endometrial Cancer
Clear Cell Endometrial Cancer and Papillary Serous Endometrial Cancer
Angiogenesis in Endometriosis
Coagulation Factors and PAR1/2 Receptors (F2R/F2RL1) in Endometriosis
Leptin Role in Endometriosis
Endometrioid Ovarian Carcinoma
Clear Cell Ovarian Carcinoma
EGFR and PTAFR Signaling in Ovarian Cancer
High-Grade Serous Ovarian Carcinoma
Low-Grade Serous Ovarian Carcinoma
Ovarian Cancer
Mucinous Ovarian Carcinoma
MIF Role in Cholesteatoma
HMGB1/RAGE Signaling in Middle Ear Cholesteatoma
Subepithelial Fibroblasts in Middle Ear Cholesteatoma
Cholesteatoma
HPV E5 Regulates EDNRA and EGFR Signaling Pathway in Keratinocytes
Prostate Cancer
TRPM8 Effects in Prostate Cancer (Hypothesis)
Steroids Induced Cataract
VEGFA in Neovascular Glaucoma
PGF2-alpha Effect on Treatment
Cytokines Trigger Otitis Media
MUC5AC Expression by NTHi and S. Pneumoniae
Alveolar Macrophage Negative Regulation Declined in COPD
VEGFA Low Expression Level in Chronic Bronchitis
VEGFA High Expression Level in Pulmonary Emphysema
Alveolar Epithelial Cell Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
Polycystins Mutation Effects in Cystic Kidney Disease
Plasmin Role in Glomerulonephritis
Endothelial Cell Dysfunction in Glomerulonephritis
Mesangial Cell Dysfunction in Glomerulonephritis
Sertoli Cells Dysfunction Causes Male Infertility
CD38/CD3 -> JUN/FOS/NF-kB Signaling in T-cell Proliferation
CD38/CD19 -> JUN/FOS/NF-kB Signaling in B-cell Proliferation
CD38 -> cADPR/Calcium Signaling
CD157 -> cADPR/Calcium Signaling
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
S100A Expression Targets
S100B Expression Targets
ANGPT1 -> CREB/CREBBP Expression Targets
ANGPT2 -> AP-1/CREBBP/MYC Expression Targets
AREG -> CREB/CREBBP Expression Targets
AREG -> SMAD1 Expression Target
AREG -> HIF1A Expression Targets
AREG -> AP-1 Expression Targets
Noradrenaline/Gs Expression Targets
Dopamine/Gs Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
Epinephrine/Gs Expression Targets
Acetylcholine Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Dopamine/Gi Expression Targets
B-Cell Receptor -> AP-1 Signaling
BTC -> AP-1/ATF/CREB Expression Targets
BTC -> EP300/ETS/ETV/SP1 Expression Targets
GLP1R -> ARRB1 Signaling
SELE -> ELK-SRF Signaling
CD19 Expression Targets
CD81 -> AP-1 Expression Targets
CD247 Expression Targets
gamma Globulins Expression Targets
FCGR3A Expression Targets
CD19/CR2 Expression Targets
CD72 -> CREB/CREBBP Expression Targets
CD8 -> ATF/CREB/CREBBP Expression Targets
CD80 -> NF-kB Expression Targets
CD86 -> NF-kB Expression Targets
CXCL6 Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CHRNA7 -> CREB Signaling
Clozapine Induced Granulocytopenia
EGF -> HIF1A Expression Targets
EGF -> AP-1/ATF Expression Targets
EGF -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
EGF -> TP53 Expression Targets
EGFR/ERBB2 -> TP53 Signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 Signaling
EGFR -> SMAD1 Signaling
EGFR/ERBB2 -> HIF1A Signaling
EGFR -> AP-1/ATF2 Signaling
EGFR -> AP-1/CREB/ELK/SRF/MYC Signaling
EREG -> CREB Expression Target
EREG -> EP300/SP1 Expression Targets
EREG -> HIF1A Expression Target
EREG -> AP-1/ATF Expression Targets
Erythropoietin -> AP-1/MYC/CREB Expression Targets
Erythropoietin -> ELK/SRF Expression Targets
PECAM1 Expression Targets
NCAM1 Expression Targets
F2 -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
PLG -> AP-1/CREB/ELK/SRF/SP1 Expression Targets
FGF9 -> AP-1/CREB/MYC Expression Targets
FGF10 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF1 -> AP-1/CREB/ELK/SRF/MYC Expression Targets
FGF7 -> RUNX Expression Targets
FGF8 -> AP-1/CREB/MYC Expression Targets
FGF1 -> RUNX Expression Targets
FGF18 -> AP-1/CREB Expression Targets
FGF8 -> RUNX Expression Targets
FGF9 -> RUNX Expression Targets
FGF4 -> AP-1/MYC Expression Targets
FGF7 -> AP-1/CREB/CREBBP/MYC Expression Targets
FGF2 -> RUNX Expression Targets
FGF2 -> AP-1/CREB/CREBBP/ELK/SRF/MYC Expression Targets
FGFR -> RUNX2 Signaling
FGFR -> AP-1/CREB/CREBBP/ELK/SRF/MYC Signaling
GCG Expression Targets
ADCYAP1 Expression Targets
FSHR Expression Targets
Glutamate/Gq Expression Targets
VIP Expression Targets
GH1/GHR -> NF-kB/ELK/SRF/MYC Expression Targets
CSH1/GHR Expression Targets
HBEGF -> AP-1/ATF Expression Targets
HBEGF -> TP53 Expression Targets
HBEGF -> EP300/ETS/ETV/SP1 Expression Targets
HBEGF -> HIF1A Expression Targets
HBEGF -> CREB/MYC Expression Targets
HGF -> AP-1/CREB/ELK/SRF/MYC Expression Targets
HGFR -> AP-1/CREB/MYC Signaling
TAM Receptor Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation in Cancer
RAS/RAF/MAPK Signaling Activation by Blocking of Tumor Suppressors
TGFB Signaling activation by Blocking of Tumor Suppressors
HIF1A in Vasculogenic Mimicry of Cancer
VEGFA Dependent Angiogenesis in Cancer
VEGF Independent Angiogenesis in Cancer
Integrins in Cancer Cell Motility, Invasion and Survival
CDH2 Activation Promotes Cancer Cell Migration and Survival
TGFB Family in Epithelial to Mesenchymal Transition in Cancer
Treg Cells Promote Immunosuppression in Cancer Immune Escape
HCAR1/HCAR2 -> MAPK Signaling
IGF2 -> HIF1A/MYC Expression Targets
IGF1 -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
Insulin -> ELK/SRF/HIF1A/MYC/SREBF Expression Targets
AGER -> CREB/SP1 Signaling
NCAM1 -> CREB/ELK/SRF/MYC Signaling
CD19 -> JUN/ELK Signaling
PECAM -> SP1 Signaling
FcIgER -> ELK-SRF Signaling
ICAM1 -> AP-1/CREB/ELK/SRF Signaling
IGF1R -> ELK/SRF/HIF1A/MYC/SREBF Signaling
InsulinR -> ELK/SRF/SREBF Signaling
FibronectinR -> AP-1/ELK/SRF/SREBF Signaling
Fibronectin Expression Targets
CTGF -> AP-1/CREB/MYC Expression Targets
ICAM1 Expression Targets
IL6R -> CEBP/ELK/SRF Signaling
IL2R -> ELK/SRF/MYC Signaling
IL1R -> NF-kB Signaling
IL4R -> ELK/SRF/HMGY Signaling
IL16 -> AP-1 Expression Targets
IL6 Expression Targets
IL4 Expression Targets
IL2 Expression Targets
UrokinaseR -> ELK/SRF Signaling
PTPRC -> BCL6 Expression Targets
Leptin -> ELK/SRF Expression Targets
Prostaglandin F Expression Targets
Thromboxane A2 Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK/SRF Expression Targets
Dronabinol/Anandamide Expression Targets
Morphine Expression Targets
S1P Expression Targets
PGE1 Expression Targets
MTNR1 Signaling
NRG1 -> EP300/ETS/ETV/SP1 Expression Targets
NRG1 -> CREB/CREBBP/ELK/SRF/MYC Expression Targets
NRG1 -> TP53 Expression Target
NRG1 -> AP-1/ATF Expression Targets
NRG1 -> HIF1A Expression Target
NGF -> AP-1/TP53/MYC Expression Targets
NGF -> FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
NGF -> CREB/CEBPB/MEF2A Expression Targets
NOTCH -> TCF3 Signaling
NOTCH Expression Targets
Adenosine Expression Targets
OR1A1 -> GNAS Signaling
PDGFB -> AP-1/CREB/MYC Expression Target
PDGFC -> CREB Expression Target
PDGFD -> AP-1 Expression Targets
PDGF -> AP-1/CREB/CREBBP/MYC Expression Targets
KIT -> MITF Signaling
PDGFR -> AP-1/MYC Signaling
AVP/Gs -> CREB/ELK/SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
NTS Expression Targets
GAST Expression Targets in GAST Expression Targets
AGT -> TP53 Expression Targets
GNRH2 Expression Targets
OXT Expression Targets
POMC Expression Targets
CCL11 Expression Targets
EDN1 Expression Targets
AGT -> CREB Expression Targets
NPY Expression Targets
IFNA1/Gq Expression Targets
AGT -> ELK/SRF Expression Targets
TAC1 Expression Targets
EDN3 Expression Targets
AVP/Gq -> CREB/ELK/SRF/AP-1/EGR Expression Targets
PRL/GHR -> NF/kB/ELK/SRF/MYC Expression Targets
PDCD1 -> AP-1 Expression Targets
PTPRC -> BCL6 Signaling
AngiopoietinR -> AP-1 Signaling
GDNF -> HSF1 Signaling
EphrinB -> MAPK/JUN/FOS Signaling
NTRK -> AP-1/CREB/ELK/SRF/MYC/SMAD3/TP53 Signaling
GAS6 -> AP-1/CREB Expression Targets
FIGF -> AP-1 Expression Target
KITLG -> AP-1/CREB/CREBBP/MYC Expression Targets
GDNF -> HSF1 Expression Targets
CSF1 -> AP-1/CREB/CREBBP/MYC Expression Targets
PGF -> AP-1/CREB/CREBBP/MYC Expression Targets
FLT3LG -> AP-1/CREB/CREBBP Expression Targets
Lysophosphatidic Acid/LPARs Signaling
Androgen Receptor non-Genomic Signaling
FOXO1 Signaling
TGF-beta Signaling
AMPK Signaling
VEGF Signaling
Estrogens/ESR1 non-Genomic Signaling
EGFR Signaling
ERK/MAPK Canonical Signaling
TCR -> AP-1 Expression Targets
T-Cell Receptor -> AP-1 Signaling
TGFA -> TP53 Expression Targets
TGFA -> HIF1A Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFA -> CREB/CREBBP/ELK-SRF/MYC Expression Targets
FASLG Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF -> AP-1 Expression Targets
CD72 -> AP-1 Expression Targets
CD40LG -> NF-kB/ELK/SRF -> CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
TNF -> ELK-SRF Expression Targets
TNF -> CREB Expression Targets
TNF -> TP53/ATF Expression Targets
EDA Expression Targets
EctodysplasinR -> AP-1 Signaling
TNFR -> CREB/ELK-SRF Signaling
TNFR -> AP-1/ATF/TP53 Signaling
NGFR -> AP-1/CEBPB/CREB/ELK/SRF/TP53 Signaling
TNFRSF6 -> HSF1 Signaling
TNFRSF1A -> AP-1/ATF/TP53 Signaling
TNFRSF1A -> CREB/ELK-SRF Signaling
Thrombopoietin -> AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin -> SP1 Expression Targets
IL1B -> NO Expression Targets
IL1B -> PGE2 Expression Targets
IL1B Expression Targets
IL1A Expression Targets
ROS in Angiotensin Mediated Cardiovascular Remodeling and Hypertrophy
PLAU -> ELK-SRF/AP-1 Expression Targets
VEGFA -> ATF/CREB/ELK-SRF Expression Targets
VEGFC -> ATF Expression Target
VEGFA -> AP-1/CREBBP/MYC Expression Targets
VEGFR -> AP-1/CREB/MYC Signaling
VEGFR -> ATF/CREB/ELK-SRF Signaling
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
1_Inflammation in keratinocytes in the pathology of acne
2_Hyperseborrhea in acne vulgaris
2_Acute phase initiation in atopic dermatitis
2_Interleukin-17 and interleukin-22 signaling in psoriasis
1_The onset of atopic dermatitis
1_TNF and IL1B provoke ECM degradation in osteoarthritis
2_Osteoblast-mediated bone demineralization
1_Formation of cysts in polycystic kidney disease
3_Enhanced angiogenesis in endometriosis
2_Impaired steroidogenesis in PCOS
1_Disruption of luteinizing hormone and follicle-stimulating hormone secretion in PCOS
2_Pathogens stimulate mucins expression in the middle ear
2_Cardiomyocyte hypertrophy
3_Dysfunction of smooth muscle cells in hypertension
1_Rise in aldosterone synthesis in adrenal zona glomerulosa cells
2_The intense proliferation and contractile activity of smooth muscle cells in pulmonary hypertension
1_Cigarette smoke causes dysfunction and production of inflammatory mediators in alveolar epithelial cells
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
3_1_Mucus accumulation in asthma
2_2_Eosinophilia and neutrophilia in asthma: eosinophil apoptosis
4_2_Airway smooth muscle cells proliferation and airway tissue remodeling
4_Mucin hyperproduction in goblet and mucous cells in COPD
1_CD4+ T cell and epithelial cell response in celiac disease
2_CD8+ T-cell response and mucosal damage in celiac disease
1_1_Insulin synthesis and secretion: insulin processing and storage
4_1_Insulin resistance: insulin signaling
1_Microangiopathy in diabetic neuropathy
2_1_General pathways of thyroid hormone signaling
public list
New Pathway
KRAS->RAFs->MAPK1/3
NRAS->RAFs->MAPK1/3
mapk1
New Pathway
mapk1 protein modificators
Interleukin-17 and interleukin-22 signaling in psoriasis

Group Proteins Involved in Cowden Syndrome
Genes Associated with Syndromic Epilepsy

Source curated
GO component

MedScan ID 5605

LocusLink ID 5605
26396
58960
29570
19102
103107
258960
619546
510434
474377
563181

Alias MAPK/ERK kinase 2
LOC82591
Map2k2
p45 MAPK kinase
MAP kinase kinase II
ERK activator kinase II
p45 MAPKK
MEK2
MEK2 protein kinase
OTTMUSP00000018442
protein kinase, mitogen activated, kinase 2, p45
MAPK/ERK kinase II
MAPKK2
Dual specificity mitogen-activated protein kinase kinase II
PRKMK2
AA589381
ERK kinase II
LOC619546
OTTMUSP00000018443
MAPK kinase II
mitogen-activated protein kinase kinase II
Dual specificity mitogen-activated protein kinase kinase 2
ERK activator kinase 2
MKK2
mitogen-activated protein kinase kinase 2, p45
CFC4
ERK kinase 2
MAPK kinase 2
OTTHUMP00000165827
mitogen activated protein kinase kinase 2
MAP kinase/Erk kinase
cardiofaciocutaneous syndrome gene
FLJ26075
MAP kinase kinase 2
LOC85511
MK2
MAPKK 2
MEK 2
mitogen-activated protein kinase kinase 2
PRKMK2s
MAPKK2s
CFC syndrome
cardiofaciocutaneous syndrome
dual specificity
kinase, mitogen activated, kinase 2, p
Olfr171
GA_x54KRFPKG5P-16071018-16070077
MOR273 I
MOR273-1
MOR273-5
olfactory receptor 171
olfactory receptor MOR273 I
olfactory receptor MOR273-1
MEK2(MAP2K2)

EC Number 2.7.12.2
2.7.1.-

GO ID 0005524
0004708
0030165
0046872
0043539
0004674
0004712
0004713
0097110
0070371
0000165
0000187
0032147
0010629
0036289
0018108
1903800
0071902
0045893
0090170
2000641
0032872
0023014
0031098
0005794
0005911
0005737
0009898
0005829
0005769
0005783
0005576
0005925
0005770
0005874
0005739
0005634
0048471
0005778
0016301
0060090
0000166
0004672
0016740
0060502
0060324
0007507
0060425
0016310
0050772
2000147
0006468
0048679
0048538
0030878
0060440
0005938
0016020
0032947
0004702
0035897
0001932
0042981
0007346
0038095
0002755
0002756
0007265
0035666
0000186
0007411
0007173
0008543
0045087
0008286
0048011
0009405
0007264
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0048010
0016772
0008063
0034130
0005625
0008152
0005515
0004930
0004984
0004872
0007186
0007608
0016021
0005575

KEGG ID hsa:5605
mmu:26396
rno:58960

MedLine Reference 8388392
12477932
1379797
14963006
8380494
8393135
8462694
10349636
10922068
10984455
11042159
11076861
11217851
11823472
12052889
12440954
12466851
12832465
14556008
15305288
15509711
15782199
16141072
16141073
16162927
16423921
16432225
16508014
16840785
16880206
16887817
17015449
17030606
7592946
7929159
8093038
8297798
8385802
8692939
9149902
9507200
10224087
10489373
10509564
10780709
10799874
10828601
10862698
10982368
11044099
11134045
11260070
11409852
11579140
11823456
11909642
12032872
12063167
12167619
12482669
12505790
12531514
12582162
12612059
12792650
12839928
14499342
14517288
14656894
14672918
14702039
15071496
15284233
15292274
15302935
15543157
15979847
16239230
16332685
16439621
16651638
17038630
7687743
7839144
8157000
8226933
8529659
8626767
8668348
8702863
9159118
9223324
9325171
9427625
9558095
9563949
9621077
9671314
9733512
9781012
9915804
12618376
11104681
15489334
16957420
16964243
17081983
17101779
17192257
17366577
17419998
17461449
17603482
1381507
15118098
16978838
17256754
17396120
17576778
15753041
8397117

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

Mouse chromosome position 10 39.72 cM
10 43.0 cM

OMIM ID 601263
615280
115150
OMIM:601263

Rat chromosome position 7q11

Hugo ID 6842
HGNC:6842

Human chromosome position 19p13.3

Swiss-Prot Accession P36507
P36507.1
Q8CB46
Q91YS7
Q63932
Q63932.2
P36506
P36506.1
Q9D7B0
A0JN15
B3KS97
Q3USU3
Q6ZPC5
Q7Z370
Q3UPM3
MP2K2_HUMAN
MP2K2_RAT
Q9D7B0_MOUSE

PIR ID A46723
A48081

GenBank ID NC_000019
XM_006722799
XP_006722862
NM_030662
NP_109587
XM_017026990
XP_016882479
XM_017026989
XP_016882478
XM_017026991
XP_016882480
NG_007996
AC016586
CH471139
EAW69262
EAW69263
EAW69264
EAW69265
KF511270
AA312322
AK093125
BAG52659
AK126446
AK129586
BAC85187
BC000471
AAH00471
BC018645
AAH18645
BX538081
CAD98005
L11285
P36507
NC_000076
XM_006513682
XP_006513745
NM_023138
NP_075627
XM_006513684
XP_006513747
XM_006513683
XP_006513746
NM_001347144
NM_001358539
AC155932
CH466553
EDL31456
EDL31457
EDL31458
EDL31459
EDL31460
AK009392
BAB26261
AK011247
AK036822
BAC29592
AK080574
BAC37945
AK138130
AK140101
BAE24237
AK143425
BAE25372
AK171584
BAE42542
AK172055
BAE42803
AK176974
AK181352
AK181608
AK186012
AK186466
AK188207
AK189608
AK192399
AK194767
AK196030
AK197970
AK198385
AK202988
AK203048
AK203356
AK208021
AK209603
AK210224
AK212183
AK212483
AK212487
AK214840
AK216389
AK217783
AK219722
AK220136
AW123542
BC014830
AAH14830
BE955857
BQ032953
CX204173
S68267
AAC60678
Q63932
NC_005106
XM_006240987
XP_006241049
NM_133283
NP_579817
AC_000075
AAHX01047467
AC120292
CH474029
EDL89191
EDL89192
EDL89193
EDL89194
EDL89195
EDL89196
BC126084
AAI26085
D14592
BAA03442
FQ215833
L14936
AAA41620
P36506
XM_011528133
XP_011526435
NC_018930
AMYH02035277
DQ893601
ABM84527
DQ895060
ABM85986
AC_000032
AAHY01086944
AC_000151
ABBA01056089
XM_005259595
XP_005259652
AABR06047713
NT_011255
NW_001838477
NW_927173
AC_000062
CR609681
CR615045
CR617539
Q6ZPC5
Q7Z370
NT_039500
NW_001030416
Q3UPM3
Q3USU3
Q8CB46
Q91YS7
Q9D7B0
NW_001084852
NW_047773
NT_079596
AC_000068
NW_000028
AW553456
XP_992860
XM_987766
BG074492
NT_039496
NR_002144
NT_086894
AAP70765
51830781
22129004
22129005
38080535
18479557
18479558
32027311
32027312
34863151
18959213
18959214
26348610
26348611
15990387
15990388
545202
545203
2499629
37552371
21614527
13489054
51475033
21751896
33875487
12653403
33879024
17391417
31874213
31874214
307184
547915
AY073130
NT_039624
NM_146958
NP_667169
NT_082357
AAL60793
AY317255
286229
303804
349544
349545
547916
51765774
31581583
31560267
12844162
12844163
26331723
26331724
116487988
123784954
123791823
74143054
74146207
74182302
74228585
81877470
81916259
81917083
AA589381
119589668
123996769
74723273
109659371
122136978
122145740
83405740
AAI11283
AAI18363
BC111282
BC118362
NC_007305
NM_001038071
NP_001033160
NW_001495330
Q17QH2
Q2T9T1
AL922183
AL923855
123889153
123907784
78394986
94732519
AAI07822
BC107821
BX088720
CAK04317
NC_007133
NM_001037391
NP_001032468
NW_001512420
Q1LY62
Q32Q50
119589669
119589670
119589671
123993851
148699509
148699510
148699511
148699512
148699513
149034454
149034455
149034456
149034457
149034458
149034459

Swiss-Prot ID MP2K2_HUMAN
MP2K2_MOUSE
MP2K2_RAT
Q3USU3_MOUSE
Q9D7B0_MOUSE
Q8CB46_MOUSE

Cell Localization Cytoplasm
Membrane
Extracellular

Ensembl ID ENSG00000126934
ENSP00000262948.3
ENST00000262948.9
ENSMUSG00000035027
ENSMUSP00000121111.1
ENSMUST00000143517.7
ENSMUSP00000100968.1
ENSMUST00000105331.7
ENSRNOG00000020005
ENSRNOP00000027272.3
ENSRNOT00000027272.5
ENSP00000262948
ENST00000262948
ENSMUSP00000121111
ENSMUST00000143517
ENSMUSP00000100968
ENSMUST00000105331
ENSRNOP00000027272
ENSRNOT00000027272

MGI ID MGI:1346867
1346867
2143493
101840
3030005

RGD ID 61888

Unigene ID Hs.465627
Mm.275436
Rn.82693
Hs.366546
Bt.8367
Dr.104532

Homologene ID 48591

Shape Sickle-vertex

IPI ID IPI00231331
IPI00135708
IPI00003783
IPI00776164
IPI00755513
IPI00443029
IPI00795187
IPI00653120
IPI00782344

Microarray ID 1398834_at
l14936_at
rc_aa957896_s_at
rc_aa963674_g_at
A_42_P653827
1415974_at
aa472313_s_at
msa.17267.0_f_at
msa.5815.0_s_at
msa.7301.0_s_at
A_51_P439626
L11285
223685_s_at
213487_at
213490_s_at
32519_at
58848_at
80459_at
202424_at
1131_at
L11285_at
A_23_P208839
A_14_P106299
A_14_P118247
A_23_P208835
C286
OH8080
R724
R613
OR0879
MB171
A_51_P123253
A_52_P26086
92543_at

Homo sapiens Chromosome position 19p13.3
12q24

Ensembl Transcript ID ENST00000262948

ENSEMBL ENSG00000126934

FunctionalClass ATP binding
kinase
nucleotide binding
protein kinase
protein serine/threonine kinase
protein-tyrosine kinase
transferase
protein binding

Hugo Symbol MAP2K2

Bos taurus Chromosome position 7

Mus musculus Chromosome position 10 43.0 cM
10

KEGG pathway Chronic myeloid leukemia
Endometrial cancer
ErbB signaling pathway
Fc epsilon RI signaling pathway
Gap junction
Glioma
GnRH signaling pathway
Insulin signaling pathway
Long-term depression
Long-term potentiation
MAPK signaling pathway
Melanogenesis
Melanoma
Natural killer cell mediated cytotoxicity
Non-small cell lung cancer
Regulation of actin cytoskeleton
Renal cell carcinoma
Thyroid cancer
VEGF signaling pathway

Rattus norvegicus Chromosome position 7q11

Ensembl Gene ID ENSG00000126934

ProteinAtlas NormalTissue Tissue: adrenal gland; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: appendix; Cell type: lymphoid tissue; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: bone marrow; Cell type: hematopoietic cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: breast; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: bronchus; Cell type: respiratory epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in granular layer; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: cells in molecular layer; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cerebellum; Cell type: Purkinje cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: cerebral cortex; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix, uterine; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: colon; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: duodenum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: epididymis; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: esophagus; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: fallopian tube; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: gall bladder; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: heart muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: hippocampus; Cell type: neuronal cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in glomeruli; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: kidney; Cell type: cells in tubules; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: glial cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lateral ventricle; Cell type: neuronal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: bile duct cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: liver; Cell type: hepatocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: macrophages; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lung; Cell type: pneumocytes; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: lymph node; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: nasopharynx; Cell type: respiratory epithelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: oral mucosa; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: follicle cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: ovary; Cell type: ovarian stroma cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: exocrine glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: pancreas; Cell type: islets of Langerhans; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: placenta; Cell type: trophoblastic cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: prostate; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: rectum; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: salivary gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: seminal vesicle; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: skeletal muscle; Cell type: myocytes; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: small intestine; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: smooth muscle; Cell type: smooth muscle cells; Level: Negative; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in red pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: spleen; Cell type: cells in white pulp; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: stomach, lower; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: stomach, upper; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: cells in seminiferus ducts; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: testis; Cell type: Leydig cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: thyroid gland; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: non-germinal center cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: tonsil; Cell type: squamous epithelial cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: urinary bladder; Cell type: urothelial cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: cells in endometrial stroma; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: uterus, post-menopause; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: cells in endometrial stroma; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: uterus, pre-menopause; Cell type: glandular cells; Level: Strong; Expression type: Staining; Reliability: Supportive
Tissue: vagina; Cell type: squamous epithelial cells; Level: Weak; Expression type: Staining; Reliability: Supportive
Tissue: vulva/anal skin; Cell type: epidermal cells; Level: Moderate; Expression type: Staining; Reliability: Supportive
Tissue: cervix
uterine; Cell type: glandular cells; Level: Moderate; Expression type: Staining; Reliability: Supportive