Protein TICAM2

URN urn:agi-llid:353376
Total Entities 0
Connectivity 227
Name TICAM2
Description toll-like receptor adaptor molecule 2
Notes TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
Primary Cell Localization Cytoplasm
ObjectType Protein

Pathway Cortisol in Resolving Inflammation
Antiviral Signaling through Pattern Recognition Receptors
TLR4 Signaling in Leukocytes
T-Cell Independent B-Cell Activation
Toll-like Receptors in Sterile Inflammation
Necrosis
MC1R in anti-Inflammatory Signaling
Macrophage M1 Lineage
CD16/CD14 Proinflammatory Monocyte Activation
AXL Receptor Inhibits Macrophages and Dendritic Cells Function
Dendritic Cells Function in Atherosclerosis
Myocardial Infarction
MAVS in Antiviral Innate Immune Response in Myocarditis
Toll-like Receptors (TLR) in Antiviral Innate Immune Response
Dendritic Cell Activation in Systemic Lupus Erythematosis
Crohn's Disease
Dendritic Cell Dysfunction in Crohn's disease
Dendritic Cell Function in Ulcerative Colitis
Nicotine anti-Inflammatory Effect in Ulcerative Colitis
Club-Cell Role in Asthma
Antigen-Presenting Cell Role in Asthma
Mucin Production in Goblet Airway Epithelial Cells
Airway Epithelial Cell Dysfunction
Monocytes Function in Gout
TLR2 Induced Synovial Fibroblast Activation in Rheumatoid Arthritis
Toll-like Receptors (TLR) in Periodontitis
IL1 Receptor Antagonist (IL1RN) Deficiency (DIRA)
PAPA Syndrome
TNF Receptor Associated Periodic Syndrome
Mevalonate Kinase Deficiency
Blau Syndrome
Cryopyrin (NLPR3) Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome 2
Familial Mediterranean Fever
Majeed Syndrome
HMGB1 and IL1B in Neuroinflammation
HPV E6 and E7 Induced Disruption of TNFR/NF-kB Signaling in Keratinocytes
Alveolar Macrophages Dysfunction in COPD
Mucin Hyperproduction in Goblet and Mucous Cells
TLR4 -> NF-kB/IRF Expression Targets
TLR4 -> IRF Signaling
pathway 4
Model of PPARG signaling in psoriasis
Model of PPARG related pathways in psoriasis (short version)
sars-cov no binding
Dendritic Cell Activation in COVID19
1_Insufficient activation of immune response in the middle ear epithelium cells in otitis media
3_Role of alveolar macrophages in pulmonary tissue destruction in COPD
1_Th2 cell response in asthma
1_Defects in response to pathogens in the gut promotes inflammation in Crohn's disease
2_Intestine epithelial cells drive immunological responses in ulcerative colitis
1_Intestine epithelial cell dysfunction in ulcerative colitis
1_Antigen-presenting cells promote islet dysfunction and immune system activation in T1D
2_Neuron and Schwann cell death
Model of PPARG signaling in psoriais (tested)

Group other partners for SARS

MedScan ID 353376

LocusLink ID 353376
225471
364867

Alias TIRAP3a
OTTHUMP00000162868
toll-like receptor adaptor molecule II
Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2
TRAM
TICAM2
TIRP
TIR domain-containing adaptor molecule 2
TIRAP3
MGC129877
TRIF-related adaptor molecule TRAM
MGC107370
MGC129876
TIRAP3a short
NF-kappa-B-activating protein 502
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
MyD88-4
toll/interleukin-1 receptor domain-containing protein
TIR-containing adaptor molecule II
toll-like receptor adaptor protein 3
OTTHUMP00000207407
TRIF-related adaptor molecule
B430113A10
toll-like receptor adaptor molecule 2
TIR-containing adaptor molecule 2
TICAM-2
cytoplasmic adaptor
putative NF-kappa-B-activating protein 502
toll/interleukin-1 receptor (TIR) domain-containing adapter protein
TIR domain-containing adapter molecule 2
Trif
TIR domain-containing adapter protein
TRIF-related adapter molecule TRAM
TIR-containing adapter molecule II
TRIF-related adapter molecule
Toll-interleukin I receptor domain (TIR)-containing adapter molecule (TICAM) 2
TIR-containing adapter molecule 2
toll-like receptor adapter molecule 2
toll-like receptor adapter molecule II

GO ID 0006888
0007030
0007249
0002756
0035669
0035666
0097190
0071222
0006954
0045087
0006886
0070266
0034128
0043312
0006909
0043123
2000494
0034145
0034142
0030134
0005794
0042995
0031901
0005783
0005793
0010008
0031902
0001891
0005886
0030667
0005149
0005543
0046982
0051607
0002376
0071650
0034144
0071651
0032729
0032755
0043122
0001817
0045357
0070671
0007165
0005737
0005769
0005768
0045323
0005770
0016020
0005622
0034138
0008063
0004871
0002224
0004888
0002755
0034130
0034134
0031224

KEGG ID mmu:225471
hsa:353376
rno:364867

Organism Homo sapiens {Organism urn:agi-taxid:9606}
Mus musculus {Organism urn:agi-taxid:10090}
Rattus norvegicus {Organism urn:agi-taxid:10116}
Homo sapiens
Mus musculus
Rattus norvegicus

Mouse chromosome position 18

OMIM ID 608321

Rat chromosome position 18q11

Hugo ID 21354
HGNC:21354

Human chromosome position 5q22.3
5q23.1

Swiss-Prot Accession Q86XR7
Q86XR7.1
Q8BJQ4
Q8BJQ4.1
D3ZXR7
Q3U996

GenBank ID NC_000005
NM_021649
NP_067681
AC010226
CH471086
EAW48960
AB002444
AB091054
BAC98397
AB097022
BAC77375
AB109098
BAC98399
AB446491
BAG55268
AY232653
AAO74498
AY304582
AAQ97431
BC109265
AAI09266
BC109266
AAI09267
BX956265
CA441688
CD638761
DA092564
DA899189
DA992598
Q86XR7
NC_000084
NM_173394
NP_775570
AC127342
CH466528
EDL09980
AB100441
BAC98398
AK054192
AK080873
BAC38055
AK134103
BAE22014
AK151885
BAE30771
AY268050
AAP29979
AY275837
AAP81749
BC099933
AAH99933
Q8BJQ4
NC_005117
NM_001108890
NP_001102360
XM_006254690
XP_006254752
AC_000086
AABR07031956
AAHX01094883
AAHX01094884
CH473971
EDM14388
EDM14394
AC_000137
XP_005272044
AMYH02012005
AAHY01138318
AAHY01138319
XM_006525868
AABR06094987
ABBA01069032
XM_005271987
AC_000040
NC_018916
XP_006525931
NT_034772
NW_001838952
NW_922751
AC_000048
NT_039674
NW_001030635
NW_047513
NW_001084736

Swiss-Prot ID TCAM2_MOUSE
D3ZXR7_RAT
TCAM2_HUMAN

Cell Localization Cytoplasm
Golgi apparatus
Cell membrane
Early endosome
Late endosome
Endoplasmic reticulum
Cell projection
Phagocytic cup

Ensembl ID ENSG00000243414
ENSP00000415139.2
ENST00000427199.2
ENSMUSG00000056130
ENSMUSP00000066239.3
ENSMUST00000070084.10
ENSRNOG00000042070
ENSRNOP00000056221.2
ENSRNOT00000059466.2
ENSRNOT00000059466
ENSMUST00000070084
ENST00000427199
ENSRNOP00000056221
ENSMUSP00000066239
ENSP00000415139
ENSMUST00000070084.9

MGI ID MGI:3040056
3040056

RGD ID 1308258

Unigene ID Rn.225789
Mm.149280
Hs.718838
Hs.709120
Mm.484659

Homologene ID 11014

IPI ID IPI00222444
IPI00782769
IPI00360266