As all of the articles published in Biomolecules (ISSN: 2218-273X) are open access, you have free and unlimited access to the full text. We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below:

1. “A Review of CYP-Mediated Drug Interactions: Mechanisms and In Vitro Drug-Drug Interaction Assessment”
by Jonghwa Lee, Jessica L. Beers, Raeanne M. Geffert and Klarissa D. Jackson
Biomolecules 2024, 14(1), 99; https://doi.org/10.3390/biom14010099
Full text available online: https://www.mdpi.com/2218-273X/14/1/99

2. “New Insights into the Role of PPARγ in Skin Physiopathology”
by Stefania Briganti, Sarah Mosca, Anna Di Nardo, Enrica Flori and Monica Ottaviani
Biomolecules 2024, 14(6), 728; https://doi.org/10.3390/biom14060728
Full text available online: https://www.mdpi.com/2218-273X/14/6/728

3. “Laccase-Mediated Oxidation of Phenolic Compounds from Wine Lees Extract towards the Synthesis of Polymers with Potential Applications in Food Packaging”
by Panagiotis E. Athanasiou, Christina I. Gkountela, Michaela Patila, Renia Fotiadou, Alexandra V. Chatzikonstantinou, Stamatina N. Vouyiouka and Haralambos Stamatis
Biomolecules 2024, 14(3), 323; https://doi.org/10.3390/biom14030323
Full text available online: https://www.mdpi.com/2218-273X/14/3/323

4. “Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy”
by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa and Mathew A. Coban
Biomolecules 2025, 15(1), 35; https://doi.org/10.3390/biom15010035
Full text available online: https://www.mdpi.com/2218-273X/15/1/35

5. “Novel Directed Enzyme Prodrug Therapy for Cancer Treatment Based on 2’-Deoxyribosyltransferase-Conjugated Magnetic Nanoparticles”
by Elena Pérez, Javier Acosta, Victor Pisabarro, Marco Cordani, José C. S. dos Santos, Jon Sanz-Landaluze, Juan Gallo, Manuel Bañobre-López and Jesús Fernández-Lucas
Biomolecules 2024, 14(8), 894; https://doi.org/10.3390/biom14080894
Full text available online: https://www.mdpi.com/2218-273X/14/8/894

6. “Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology”
by Rahul S. Patil, McKenzie E. Maloney, Rudolf Lucas, David J. R. Fulton, Vijay Patel, Zsolt Bagi, Anita Kovacs-Kasa, Laszlo Kovacs, Yunchao Su and Alexander D. Verin
Biomolecules 2024, 14(2), 140; https://doi.org/10.3390/biom14020140
Full text available online: https://www.mdpi.com/2218-273X/14/2/140

7. “An Engineered Laccase from Fomitiporia mediterranea Accelerates Lignocellulose Degradation”
by Le Thanh Mai Pham, Kai Deng, Hemant Choudhary, Trent R. Northen, Trent R. Northen, Steven W. Singer, Paul D. Adams, Blake A. Simmons and Kenneth L. Sale
Biomolecules 2024, 14(3), 324; https://doi.org/10.3390/biom14030324
Full text available online: https://www.mdpi.com/2218-273X/14/3/324

8. “PPARs in Clinical Experimental Medicine after 35 Years of Worldwide Scientific Investigations and Medical Experiments”
by Anna Skoczyńska, Monika Ołdakowska, Agnieszka Dobosz, Rajmund Adamiec, Sofya Gritskevich, Anna Jonkisz, Arleta Lebioda, Joanna Adamiec-Mroczek, Małgorzata Małodobra-Mazur and Tadeusz Dobosz
Biomolecules 2024, 14(7), 786; https://doi.org/10.3390/biom14070786
Full text available online: https://www.mdpi.com/2218-273X/14/7/786

9. “CYP3A-Mediated Carbon–Carbon Bond Cleavages in Drug Metabolism”
by Junhui Zhou, Xuan Qin, Shenzhi Zhou, Kevin R. MacKenzie and Feng Li
Biomolecules 2024, 14(9), 1125; https://doi.org/10.3390/biom14091125
Full text available online: https://www.mdpi.com/2218-273X/14/9/1125

10. “Evaluation of Antibiotic Biodegradation by a Versatile and Highly Active Recombinant Laccase from the Thermoalkaliphilic Bacterium Bacillus sp. FNT”
by Jorge Sánchez-SanMartín, Sebastián L. Márquez, Giannina Espina, Rodrigo Cortés-Antiquera, Junsong Sun and Jenny M. Blamey
Biomolecules 2024, 14(3), 369; https://doi.org/10.3390/biom14030369
Full text available online: https://www.mdpi.com/2218-273X/14/3/369