- Communication
Characterizing the Effects of Voluntary Wheel Running on Cardiac SERCA Function in Ovariectomized Mice
- Bianca M. Marcella,
- Mia S. Geromella,
- Ahmad Mohammad,
- Jacob Sweezey-Munroe,
- Rebecca E. K. MacPherson and
- Val A. Fajardo
The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) actively transports Ca2+ into the sarcoplasmic reticulum to facilitate cardiac muscle relaxation. Phospholamban (PLN) allosterically inhibits SERCA, and an imbalance of SERCA2a, dominant cardiac is...

