We investigated the associations between the incidence rates of five typical cancer types and five air pollutants in 317 Japanese municipalities in 2017. We obtained the concentrations of the five air pollutants, i.e., sulfur dioxide (SO
2), nitric oxide (NO), nitric dioxide
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We investigated the associations between the incidence rates of five typical cancer types and five air pollutants in 317 Japanese municipalities in 2017. We obtained the concentrations of the five air pollutants, i.e., sulfur dioxide (SO
2), nitric oxide (NO), nitric dioxide (NO
2), photochemical oxidants (O
x), and fine particulate matter (PM
2.5), from Japan’s National Institute for Environmental Studies and calculated the yearly mean of each. We identified patients of both sexes with the five most common cancers in Japan’s National Cancer Registry, which covers all cancer patients in the country. For males, we included prostate, stomach, colorectal, lung, and liver cancers. For females, we included breast, colorectal, lung, stomach, and uterine cancers. We calculated the Spearman’s correlation coefficients between 25 pairs of air-pollutant concentrations and the age-standardized incidence rate of the cancer types for each sex. We used Poisson regression models to examine the dose–response relationships. We identified 11 significantly positive correlation coefficients at the Bonferroni-corrected alpha level for the five pollutants for the five cancers in both sexes. We observed significantly positive dose–response relationships between NO
2 and colorectal cancer and PM
2.5 and lung cancer for both sexes. We also observed significant dose–response relationships between SO
2 and PM
2.5 and liver cancer for males and between NO and lung cancer and NO
2 and breast cancer for females. We did not observe significant associations with prostate, stomach, or uterine cancer. Our findings support the concept that exposure to air pollutants increases cancer incidence rates.
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