CAD/CAM Abutments versus Stock Abutments: An Update Review

: With the evolution of CAD/CAM technology, custom titanium and/or zirconia abutments are increasingly being used, leading to several comparisons in the literature, both mechanical and aesthetic, to evaluate performance differences between these two types of abutments. Therefore, the aim of this comprehensive review is to present the most recent data on the latest comparisons between CAD/CAM and stock abutment applications. The PICO model was used to perform this review, through a literature search of the PubMed (MEDLINE) and Scopus electronic databases. CAD/CAM abutments allow individualization of abutment parameters with respect to soft tissue, allow increased fracture toughness, predict the failure mode, show no change in the fracture toughness over time, reduce the prosthetic steps, and reduce the functional implant prosthesis score and pain perceived by patients in the early stages. The advantages associated with the use of stock abutments mainly concern the risk of corrosion, time spent, cost, and ﬁt, evaluated in vitro, in the implant–abutment connection. Equal conditions are present regarding the mechanical characteristics during dynamic cycles, screw loss, radiographic ﬁt, and degree of micromotion. Further randomized controlled clinical trials should be conducted to evaluate the advantages reported to date, following in vitro studies about titanium and/or zirconia stock abutments.


Introduction
Osseointegration and long implant longevity were the initial challenges of implantsupported prosthetic oral rehabilitation, which have been widely addressed in the literature to date [1].
Over time, given the increased expectations of patients, achieving a satisfactory aesthetic result has become progressively important, and this can also be achieved through high-quality prosthetic structures and customised morphology [2].Additionally, it is necessary to establish the correct relationship between peri-implant mucosa, alveolar bone, and prosthetic materials [3].Finally, peri-implant soft tissue also provides a protective barrier between the oral cavity and the underlying bone [4].
Mechanical loading, radiotherapy, prosthetic interference, and microbial biofilm negatively affect the transition zone between the mucosa and the abutment, compromising implant longevity [5,6].
Biofilm represents the primary etiological factor in the development of peri-implant mucositis and peri-implantitis [7], whose prevalence can reach 80% and 56%, respectively [8].In this regard, recent studies highlighted that the peri-implant microbiota shows less bacterial differentiation than the periodontal microbiota, becoming more complex when moving from peri-implant mucositis to peri-implantitis [9,10].Scaling and root planning represents the gold standard of nonsurgical treatment for peri-implant pathology, with some shortcomings, among which bacterial recolonization is the most represented [11].As a result, additional therapeutic approaches have been proposed, including antibiotics [12], ozone application [13], photodynamic treatment [14,15], and probiotics [16], which have no side effects, and their anti-inflammatory effects toward peri-implant disease have been examined in a few studies [17,18].
Previous studies have defined how the material (titanium, precious alloys, alumina, and zirconia) and morphology of the abutment appear to be critical in ensuring proper epithelial-connective attachment between the mucosa and the abutment, stabilizing the mucosal margin and ensuring proper interproximal filling [19,20].
In addition, the functionality of implant-supported restorations and the health and stability of the peri-implant soft tissues is influenced by several other factors, such as the design and stability of the implant-abutment connection and the chemical composition and surface properties of the abutment constituent material [21].
Surface topography, surface free energy, and especially surface roughness are important factors in biofilm formation [22].The optimal abutment surface should be smooth enough to prevent biofilm formation but rough enough (0.2 microns) to allow fibroblast adhesion [23].
Before the introduction of CAD/CAM technology (Computer-Aided Design/Computer-Aided Manufacturing), two main types of abutments were available: stock abutments, provided by dental implant manufacturers, and custom cast abutments [24].
Recently, implant abutments have also been produced by CAD/CAM technology; they can be adapted to individual and local situations, offering different advantages.Moreover, different materials can be used to realize abutments with CAD/CAM technology [25].
The respective advantages related to the use of CAD/CAM and stock abutments led to comparisons in the literature, both mechanical and aesthetic, aimed to assess differences in the performances between these two types of abutments.
Therefore, the aim of this review is to present the most recent data regarding the latest comparisons between the applications of CAD/CAM and stock abutments.

Focused Questions
Are there differences in the clinical performances between CAD/CAM abutments and stock abutments?What are the advantages in the application of the two types of abutments?Are there any equal conditions of use?

Eligibility Criteria
The following inclusion criteria guided the analysis of the studies: Type of studies.Clinical trials, case-control studies, cross-sectional studies, cohort studies, narrative reviews, and systematic reviews.
Type of participants.Patients with titanium and/or zirconia CAD/CAM abutments and stock titanium and/or zirconia abutments for implant rehabilitations and in vitro models in which the mechanical properties of the two types of abutments were tested.
Type of interventions.Comparison of the clinical, mechanical, and esthetic performances of titanium and/or zirconia CAD/CAM abutments and titanium and/or zirconia stock abutments, assessed through case-control, cross-sectional, cohort, clinical, and review studies.
Outcome type.Identification of the advantages and equal conditions of using titanium and/or zirconia CAD/CAM abutments and titanium and/or zirconia stock abutments, both in vitro and for clinical use.
Only studies that met all the inclusion criteria were included.However, the following exclusion criteria were considered: (I) articles published in non-English languages, (II) studies where non-titanium or zirconia abutments were tested, (III) the presence of concomitant systemic diseases/treatments that could influence the results, (IV) animal clinical studies, and (V) the absence of ethics committee approval.

Search Strategy
The PICO model (Population, Intervention, Comparison, and Outcome) was used to perform this review through a literature search of the PubMed (MEDLINE) and Scopus electronic databases.Abstracts of studies that compared the mechanical and aesthetic characteristics, in vitro and in clinical use, of titanium and/or zirconia CAD/CAM abutments and titanium and/or zirconia stock abutments were reviewed.

Results
CAD/CAM abutments allow the individualization of abutment parameters in implant rehabilitation with respect to soft tissue, reducing the risk of cement remaining in the peri-implant sulcus, improving the tissue support and papillary recession index .Moreover, they allow for increased fracture toughness (two-piece CAD/CAM zirconia), and predict the failure mode (if containing titanium inserts).In clinical use, they show no change in the fracture toughness over time, and finally, CAD/CAM technology used in the construction of healing abutments makes it possible to reduce the prosthetic steps and reduce the functional implant prosthodontics score and pain perceived by patients in the early stages.
The advantages associated with the use of stock abutments relate primarily to the risk of corrosion, time spent, cost, and fit, assessed in vitro, in the implant-abutment connection.
Equal conditions are present regarding the mechanical characteristics at the dynamic cycles, screw loss, radiographic fit, and degree of micromotion .

Risk of Bias
The risk of bias of the main articles reviewed is shown in Table 1.This review has a moderate risk of bias.
The results of the search reveal that, with the MeSH terms "dental abutments" AND "dentistry", there were 11,440 articles; with "dental abutments" AND "dental implants", there were 13,778 publications; and with "dental abutments" AND "computer-aided design" AND "computer-aided manufacturing" 1219 articles, with "dental abutments" AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.
bias of the studies is represented by the green symbol for a low risk of bias and a or a moderate risk of bias.

Concealment
Blinding Incomplete Outcome Data

Registration Outcome Data
AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mecha tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mec tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mecha tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mec tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mecha tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mec tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mec tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mecha tests", there were 821 publications.AND "dental esthetics" 2177 articles, and with "dental abutments" AND "mechanical tests", there were 821 publications.Figure 1 shows the trend of publications over the years regarding CAD/CAM and stock abutment population studies.Using the keywords "dentistry" AND "abutments", the first study present in PubMed (MEDLINE) dates back to 1945 [49]; however, in Scopus, until 1955 [50], there were no studies; with the keywords "CAD/CAM" AND "abutments", the first study present in PubMed (MEDLINE) dates back to 1976 [51], while, in Scopus, the first study dates back to 1989 [52].Until the 1980s, before the introduction of CAD/CAM, only standard abutments were on the market.Since the early 2000s, CAD/CAM has become increasingly used in clinical dental practice, leading to the introduction of the first CAD/CAM abutments.However, this resulted in the introduction of the term "stock" to differentiate standard versus digitally individualized abutments.From 2007 to 2011, an increase was seen with the keywords "dentistry" AND "abutments" from 275 articles to 518, while, for "CAD/CAM" AND "abutments", the trend changed from 17 to 68 publications; from 2011 to 2021, the trends for both keywords increased from 518 articles to 616 and from 68 to 155, respectively, for "dentistry" AND "abutments" and "CAD/CAM" AND "abutments".Up to the beginning of the year 2022, there have been 291 and 73 articles about the keywords "dentistry" and "CAD/CAM", respectively.The increased number of studies regarding the use of CAD/CAM highlight the great clinical interest in this well-established method, making dentistry increasingly individualized and digital.

Discussion
Through CAD/CAM technology, it is possible to optimize the geometry of the abutment, particularly the position of the finish line according to the roots of the contiguous tooth elements and the gingival margin, thus reducing the possibility of leaving cement remnants in the peri-implant sulcus [26,53].
CAD/CAM abutments have an excellent finishing line, thus avoiding sharp edges.They also compensate for poor implant angulation and provide a biological advantage, as they support and interact with the soft tissues, unlike stock abutments, in which it is the crown that performs this function [27].On the other hand, stock abutments have several advantages: the industrial manufacturing process standardizes the quality of the product and ensures the use of biocompatible materials in the abutment-soft tissue interface [28].Finally, there is less risk of corrosion due to the possible use of different alloys in the milled parts, and it is less time-consuming and expensive [29].
A recent study by Schepke et al. [30] showed that there is no significant difference in fracture toughness for the CAD/CAM zirconia abutments compared to their pristine copies after 1 year of clinical service, unlike the stock zirconia abutments, which showed a significant reduction in fracture toughness, although the maximum fracture toughness values still exceeded human chewing forces, which can exceed 250 N.However, for the zirconia abutments, it was possible to get a good fit and stability only with a conical connection and in the anterior zone, whereas, in the posterior area and in the internal hexagon connection, the use of zirconia abutments is not recommended [54].
In addition, abutments containing titanium inserts had higher fracture resistance than the full zirconia abutment.Titanium inserts affect the fracture patterns of the zirconia abutments.In case of a fracture, the presence of a titanium reinforcement leads to a higher possibility of a horizontal fracture surface.Without titanium inserts otherwise, an oblique fracture is more likely.Moreover, the titanium insert keeps the buccal fracture surface of the zirconia abutment away from the implant platform, thus protecting the implant-abutment connection [31].
Previous in vitro studies evaluated the static load fracture resistance of one-piece CAD/CAM zirconia abutments compared with stock zirconia abutments, showing that one-piece CAD/CAM zirconia abutments have lower static fracture loads than their stock counterparts [45,46].Furthermore, dynamic loading can improve the fracture resistance of zirconia abutments, and two-piece CAD/CAM zirconia abutments are an equivalent alternative to titanium abutments in a single-implant restoration in the anterior region [47].One-piece CAD/CAM zirconia abutments provided less favorable mechanical properties in fracture loads than two-piece CAD/CAM zirconia abutments and titanium abutments.The weakest point of one-piece CAD/CAM zirconia abutments was the area around the screwhead under dynamic loading and the internal connection under static loading [34].
Likewise, the studies by Schepke et al. [29] and Gehrke et al. [32] showed that twopiece CAD/CAM zirconia abutments with an internal hexagonal connection demonstrated a greater fracture resistance than single-piece CAD/CAM zirconia and stock zirconia abutments.Based on these results, two-piece abutments could be clinically advantageous in high-load areas, such as single premolar and molar tooth replacements.
However, the prospective cohort study by Fonseca et al. [33], with a follow-up of 4.5-8.8years, showed how screw-retained implant crowns based on CAD/CAM zirconia abutments with a conical connection exhibited excellent clinical performance, recommending them for the replacement of missing anterior teeth and premolars.
Furthermore, assessing the implant-abutment interface after the dynamic loading of conventional titanium abutments compared to CAD/CAM zirconia abutments, the microgap values at the implant-abutment interface are equivalent to each other, demonstrating how CAD/CAM zirconia abutments can withstand functional forces, as well as stock titanium abutments [40].
Regarding peri-implant soft tissues, Lops et al. [35] showed that, for restorations supported by stock abutments, the mean papillary recession index (REC) was higher than for CAD/CAM abutments, both for titanium and zirconia abutments, in which slight papilla regrowth was also measured after 2 years of follow-up.
CAD/CAM abutments combine most of the advantages of stock and cast abutments since, in addition to a predictable fit and durability, all prosthetic parameters are modifiable, including the emergence file, thickness, finish line position, and outer contour [36].For these reasons, a CAD/CAM abutment could improve the papilla support and avoid excessive papilla compression [37].In addition, a clinical study showed how CAD/CAM technology used in the development of healing abutments requires fewer steps for prosthetic finalization than the standard healing abutments customized step by step with composite.Additionally, CAD/CAM healing abutments allow for a higher functional implant prosthodontics score, commonly used to evaluate both the functional and aesthetic results, and the perceived pain is less in the early stages of prosthetic rehabilitation [38].
Abutment material does not determine any significant difference in the degree of papillary recession for either stock abutments or CAD/CAM abutments made of titanium and zirconia, given the biocompatibility of these materials [39].
It has been shown that, after the application of 5000 cycles of cyclic loading, with a force between 10 N and 250 N, there is no significant difference in screw loosening with the titanium stock abutment or titanium CAD/CAM abutment, highlighting that the connection of the CAD/CAM abutment to the fixture was as stable as that of the stock abutment [41].Therefore, good stability of the screw joint could be achieved by performing a precise examination of the CAD/CAM abutments [24].However, it must be considered that, in the research by Paek and colleagues [41], a dynamical force from 10 N to 250 N has been applied, which is much lower with respect to the masticatory forces that humans can apply, ranging between 300 and 500 N [55]; therefore, further studies are aimed at evaluating the mechanical behavior of CAD/CAM abutments also under maximum load conditions.
Regarding the precision of the implant-abutment connection between the CAD/CAM and stock abutments, the study by Apicella et al. [44] was the only one to date performed in which the fit was investigated by radiography and scanning electron microscopy (SEM).The results showed that the fit achievable with CAD/CAM abutments was comparable to that of the stock abutments.
In vitro studies on stock titanium abutments showed a significantly higher volume of material involved in the implant-abutment connection than CAD/CAM titanium abutments [42].In fact, the frictional fit achieved with the stock abutment is better than the CAD/CAM abutment connected to the same implant system [43].
Finally, it has been reported that micromotion at the implant-abutment interface, a major determinant of long-term implant success, since technical problems related to screw loosening and a subsequent fracture may be due to excessive micromotion, does not present significant differences between zirconia CAD/CAM abutments and titanium stock abutments [48].
Based on the most recent literature, it is possible to assert that the use of CAD/CAM abutments has more advantages than stock abutments, both mechanical and aesthetic.From the in vitro studies performed to date, there are some common features, such as mechanical resistance to dynamic cycling, radiographic fit, and micromotion at the implantabutment interface.However, some inherent advantages of using non-individualized abutments persist, such as time and cost, although some recent in vitro studies have shown mechanical advantages over one-piece CAD/CAM abutments and a better implantabutment connection.
A summary table of the advantages and common aspects of CAD/CAM and stock abutments included in this work is shown in Table 2.

CAD/CAM Abutments Advantages
References and Study Details CAD/CAM abutments containing titanium inserts had higher fracture resistance than solid zirconia abutment; this conditioned the type of fracture, mainly horizontal, and the location of the fracture, mainly buccal, distant from the implant platform.
Chang et al. 2022 [31]: in vitro investigation comparing three groups of zirconia abutments (n = 5) consisting of different connection designs or manufacturers (All-Zr, ASC-Zr, and AM-Zr groups) All prosthetic parameters are modifiable, including emergence file, thickness, outer contour, position of the finish line in relation to the roots of contiguous tooth elements and the gingival margin, predictable fit, and durability.
Cantieri Mello et al. 2019 [36]: systematic review and meta-analysis of 11 in vitro studies After 1 year of clinical service, no difference in fracture toughness was found for the CAD/CAM zirconia abutments compared with their pristine copies.[26]: review Abutment material does not determine any significant difference in the degree of papillary recession for either stock abutments or CAD/CAM abutments made of titanium and zirconia, given the biocompatibility of these materials.

Stock abutments advantages
One-piece CAD/CAM zirconia abutments have lower static fracture loads than their stock counterparts.
The volume of material involved in the implant-abutment connection is higher than CAD/CAM titanium abutments and the frictional fit achieved with the stock abutment is better than the CAD/CAM abutment connected to the same implant system.
Lops et al. 2018 [42]: in vitro study comparing 10 CAD/CAM titanium abutments with 10 stock titanium abutments Alonso-Pérez et al. 2017 [43]: in vitro study comparing 13 implants connected to original stock abutments and 13 implants connected to nonoriginal laser-sintered abutments Better internal fit with respect to CAD/CAM abutments Lops et al. 2018 [42]: in vitro study comparing 10 CAD/CAM titanium abutments with 10 stock titanium abutments Apicella et al. 2010 [44]: radiographic and SEM analysis on 12 titanium abutments, 12 stock zirconia abutments, and 12 third party zirconia abutments Less risk of corrosion due to the possible use of different alloys in the milled parts; less time-consuming and expensive.
Ragupathi et al. 2020 [56]: in vitro study on 10 titanium abutments and 10 PEEK abutments Souza et al. 2020 [57]: review Industrial manufacturing process standardizes the quality of the product and ensuring the use of biocompatible materials in the abutment/soft tissue interface.

Common aspects
After application of 5000 cycles of cyclic loading, with a force between 10 N and 250 N, there is no significant difference in screw loosening with titanium stock abutment or titanium CAD/CAM abutment, highlighting that the connection of the CAD/CAM abutment to the fixture was as stable as that of the stock abutment.
Paek et al. 2016 [41]: in vitro study on stock and customized CAD/CAM abutments Micromotion at the implant-abutment interface does not present significant differences between zirconia CAD/CAM abutments and titanium stock abutments.
Karl and Taylor 2014 [48]: in vitro study on CAD/CAM zirconia and CAD/CAM titanium abutments Radiographic and scanning electron microscopy (SEM) investigations have shown that the fit achievable with CAD/CAM abutments is comparable to that of stock abutments.
Apicella et al. 2010 [44]: radiographic and SEM analysis on 12 titanium abutments, 12 stock zirconia abutments, and 12 third party zirconia abutments Two-piece CAD/CAM zirconia abutments are an equivalent alternative to titanium abutments in a single-implant restoration in the anterior region.
Wittneben et al. 2020 [47]: 3-year randomized clinical trial After dynamic loading, microgap values at the implant-abutment interface are equivalent, demonstrating that CAD/CAM zirconia abutments can withstand functional forces as well as stock titanium abutments.
Coray et al. 2016 [40]: systematic review and meta-analysis on 7 studies The present report presents some limitations.It is possible that the search methodology did not take into account all the articles in the literature, with particular reference to the gray literature and unindexed research.Moreover, these results may be different depending on the population considered.Most of the articles currently in the literature are in vitro studies, so there is a lack of clinical evidence.Another limitation is that CAD/CAM abutments can be realized in the same factory as the implants or by other companies; since it is not always specified in the articles, this aspect should be inserted, as it was demonstrated that some differences can occur between them [58].Finally, the heterogeneity within CAD/CAM and stock abutments complicates the comparison between them; while CAD/CAM abutments may use the same materials as stock abutments, many materials may be used for CAD/CAM abutments; therefore, it may be difficult to get a general comment/generalizability on this topic.
Future research perspectives could include further randomized controlled clinical trials that should be conducted to evaluate the advantages reported to date, following in vitro studies, of using titanium and/or zirconia stock abutments.

Conclusions
The advantages of using CAD/CAM abutments are many and exceed the advantages of using stock abutments.
CAD/CAM abutments allow the clinician to individualize the abutment parameters in implant rehabilitation, respecting the soft tissue and maintaining excellent mechanical characteristics.
However, some advantages associated with the use of stock abutments remain, such as the risk of corrosion, time spent, cost, and in vitro assessed fit of the implant-abutment connection.The accuracy of the latter advantage will need to be evaluated clinically.

Figure 1 .
Figure 1.Number of research papers published up to 2022.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Se- quence Generated Allocation Concealment Blinding Incomplete Out- come Data Registr Outcom
of the studies is represented by the green symbol for a low risk of bias and a or a moderate risk of bias. bias

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.Adequate Se-

Generated Allocation Concealment Blinding Incomplete Out- come Data Registration Outcome Data
Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Haugen Håvard et al. 2022 [39] Prosthesis 2022, 4, FOR PEER REVIEW AND "dental esthetics" 2177 articles, and with "dental abutments tests", there were 821 publications.Table 1.Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Haugen Håvard et al. 2022 [39] Prosthesis 2022, 4, FOR PEER REVIEW 4

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Alsahhaf Abdulaziz et al. 2017 [34] Prosthesis 2022, 4, FOR PEER REVIEW 4

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Beretta Mario et al. 2019 [38] Prosthesis 2022, 4, FOR PEER REVIEW 4

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Alsahhaf Abdulaziz et al. 2017 [34] Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.Alsahhaf Abdulaziz et al. 2017 [34] Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 [37] Lops Diego et al. 2017 [35] Prosthesis 2022, 4, FOR PEER REVIEW 4

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Fonseca Manrique et al. 2021 [33] Alsahhaf Abdulaziz et al. 2017 [34] Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.Fonseca Manrique et al. 2021 [33] Alsahhaf Abdulaziz et al. 2017 [34] Lops Diego et al. 2017 [35] Cantieri Mello Caroline et al. 2019 [36] Lops Diego et al. 2015 Prosthesis 2022, 4, FOR PEER REVIEW

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.Adequate Se-

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.Schepke Ulf et al. 2019 [30] Chang Yu-Tsen et al. 2022 [31] Gehrke Peter et al. 2015 [32] Fonseca Manrique et al. 2021 [33] Prosthesis 2022, 4, FOR PEER REVIEW 4

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.Schepke Ulf et al. 2019 [30] Chang Yu-Tsen et al. 2022 [31] Gehrke Peter et al. 2015 [32] Fonseca Manrique et al. 2021 [33] IEW 4

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bias and a yellow symbol for a moderate risk of bias.

Table 1 .
Risk of bias of the studies is represented by the green symbol for a low risk of bia yellow symbol for a moderate risk of bias.

Table 2 .
Summary table of the advantages and equalities of CAD/CAM and stock abutments.
Schepke et al. 2019[30]: ex vivo study on 23 stock and 23 CAD/CAM customized zirconia implant abutments Two-piece CAD/CAM zirconia abutments with an internal-hex connection demonstrated greater fracture resistance than one-piece CAD/CAM zirconia and stock zirconia abutments.Gehrke et al. 2015 [32]: in vitro experiments on 21 abutment-crown specimens Mostafavi et al. 2021 [29]: randomized clinical trial with 50 participants Excellent finish, compensates poor implant angulation, and supports and interacts with soft tissue.Valsan et al. 2021 [27]: clinical report CAD/CAM healing abutments require fewer steps for prosthetic finalization than standard healing abutments, allow for a higher functional implant prosthodontics score, and perceived pain is less in the early stages of prosthetic rehabilitation.Beretta et al. 2019 [38]: randomized controlled clinical trial with 20 participants Screw-retained implant crowns based on CAD/CAM zirconia abutments with conical connection exhibited excellent clinical performance.Fonseca et al. 2021 [33]: prospective cohort study, with a 4.5-8.8-yearfollow-up on 32 patients with 40 implant single crowns CAD/CAM abutment-supported restorations in titanium and zirconia have lower mean papillary recession index than stock abutments, improving papilla support and avoid excessive papilla compression.Lops et al. 2017 [35] and Lops et al., 2015 [37]: 2-year prospective multicenter cohort studies Reduction of the risk of cement remaining deep in the peri-implant sulcus in the cemented prosthesis.Edelhoff et al. 2019