A Wearable Internet of Things Device for Noninvasive Remote Monitoring of Vital Signs Related to Heart Failure

: Cardiovascular disease is one of the leading causes of death in the world. Heart failure is a cardiovascular disease in which the heart is unable to pump sufficient blood to fulfill the body’s requirements and can lead to fluid overload. Traditional solutions are not adequate to address the progression of heart failure. Herein, we report a body-mounted wearable sensor to monitor the parameters related to heart failure. These include heart rate, blood oxygen saturation, thoracic impedance, and activity status. The device is compact and wearable and measures the parameters continuously in real time. The device is an Internet of Things (IoT) device connected with a cloud-based database enabling the parameters to be visualized on a mobile application.


Introduction
Cardiovascular diseases are related to heart and blood diseases [1].They account for one-third of the deaths around the world with more than half a billion people affected.Heart failure (HF) is a serious cardiovascular disease with approximately 56.19 million cases around the world and 6.5 million in the US alone [2,3].In this condition, the heart cannot pump a sufficient amount of blood to meet the requirements of the body.This lack of blood supply can lead to fluid overload and pulmonary edema, whereby fluid builds up in the lungs [4].There are two main types: HF with preserved ejection fraction (HFpEF), also known as diastolic HF, and HF with reduced ejection fraction (HFrEF), also known as systolic HF [5].In HFpEF, the heart pumps 50% or more of the amount of blood in the left ventricle, whereas in reduced ejection fraction less than or equal to 40% of blood is ejected.HF is difficult to treat completely however it can be managed by guideline-directed medical therapy and monitoring significant parameters [5].These include heart rate (HR), oxygen blood saturation (SPO2), thoracic impedance, and activity status of the subject.Current solutions for managing HF are implantable cardioverter defibrillators (ICDs) and CardioMEMS [6].An ICD is an invasive solution in which a device is implanted inside the chest and used to monitor parameters related to HF, as well as treating irregular heart rhythms.The HF management program from Medtronic utilizes one such ICD that monitors parameters including HR, heart rate variability (HRV), activity status, and thoracic impedance [7][8][9].CardioMEMS is another invasive device that monitors the progression of HF using pulmonary artery pressure [8,10].
These devices not only have surgical risks but are also very expensive.According to one estimate, an ICD costs approximately USD 37,000 and CardioMEMS costs approximately USD 17,750 [11,12] and, therefore, are not accessible for all HF patients.Moreover, ICDs are only recommended for patients with HFrEF.Therefore, there is a need for a cost-effective solution that is accessible to all HF patients.According to the World Health Organization (WHO), diagnostic tools should be in accordance with the ASSURED criteria, whereby ASSURED stands for affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable devices.Internet of Things (IoT)-based wearable devices are one such solution that can provide continuous real-time monitoring and in accordance with the ASSURED criteria [13][14][15].IoT is an integration of different things, such as sensors and software, embedded together for exchanging useful data over the Internet [16].IoT allows for remote monitoring that not only provides timely monitoring and diagnosis but also has the potential to reduce healthcare costs [17].Wearable devices have been found to be an effective tool for the use of IoT in healthcare [18].Recently, efforts have been made for using wearable devices for various medical applications.Some efforts have also been made for the use of wearable devices specifically for HF management and monitoring [19][20][21][22].Notable examples include a wearable vest for HF monitoring, a hemotag, and a wearable belt for monitoring vital cardiovascular parameters [23][24][25].The wearable belt by Svagard et al. is a chest-based belt that measures transthoracic impedance (TTI) and weight to monitor HF [23].They have found TTI to be 76% sensitive enough to HF and 33% sensitive to body weight.However, this device is not only bulky for the patient, but it is not a real-time continuous monitor, as it is only required to be used for 10 minutes to extract parameters.Moreover, it is not fully wearable in nature such that it cannot be used at all times and in all conditions, as it is only required to be used in resting conditions.Similarly, a hemotag can only be used in a resting position [24]; it monitors HF using time-synchronized vibrations from the chest for only 30 secs.Moreover, the wearable belt by Svagard et al. is a multiparametric belt for monitoring different vital cardiovascular parameters, such as heart rate and activity level, along with other vital parameters, including skin temperature, but does not include the most specific HF parameter, thoracic impedance [25].Thoracic impedance is a vital indicator for measuring fluid accumulation and is a specific diagnostic indicator for HF.Herein, we report a wearable device that can monitor vitals related to HF in different real-time conditions at all times.
The device measures parameters such as thoracic impedance, oxygen saturation in blood (SPO2), HR, and activity status.Thoracic impedance is the electrical impedance in the lung region and is a vital indicator for HF progression, as it decreases in the presence of pulmonary fluid.SPO2 is the measure of blood oxygen saturation and is measured as the percentage of oxygen in the blood.It is an important parameter for evaluating heart function and, hence, a vital indicator for the management of HF.It can also have HF diagnosis and prognostic abilities.According to one study conducted on 220 patients with myocardial infraction, an acute setting in HF, it was found that SPO2 may have diagnostic and prognostic implications especially when the baseline SPO2 is less than 93% [26].A healthy subject has an SPO2 greater than 95% [27].Similarly, HR is the measure of the number of heartbeats each minute.In HF, to make up for the lack of blood supply, the heart may beat faster than normal and, therefore, HF patients may have a higher HR than the normal range of 60-100.Moreover, during the progression of HF, patients experience fatigue or swelling in the legs due to a lack of blood supply, which leads to a loss of activity [28].Therefore, monitoring activity status can help in monitoring and managing HF.
Traditional ICDs measure multiple parameters for the management of HF.The proposed device measures these parameters noninvasively and continuously in real time and is connected with a cloud database.We also developed a Wi-Fi-enabled mobile application (App) in which the data for each patient are stored in the database and can be visualized on the App.We tested this device with 10 subjects in three different real-time conditions such as sitting, standing, and walking.The developed wearable device can help monitor multiple HF-related parameters in real-time, thus providing more effective disease management.

Methods
The device measures parameters related to heart failure including thoracic impedance, HR, SPO2, and activity status using three different sensors: thoracic impedance sensor, MAX30101, and ADXL 362 [29,30].The thoracic impedance sensor was built, whereas MAX30101 and ADXL362 are low-cost, off-the-shelf components.This section discusses the development of the body-mounted wearable sensor including the development of the thoracic impedance sensor.It also discusses the protocol of experimentation performed using this device.

Sensor Development
The body-mounted wearable device, as shown in the Figure 1a,b, is housed inside a 70 × 48 mm 2 3D casing that can be attached on the chest using a medical-grade doublesided adhesive (DSA).The attachment of the device is shown in Figure 1c.The sensor consists of three different sensors connected to an Arduino MKR 1010 microcontroller.The thoracic impedance sensor and MAX30101 connects with the microcontroller using the I 2 C protocol, whereas the ADXL 362 connects using the SPI protocol [31,32].Figure 1d shows a schematic of the thoracic impedance sensor that we developed.The thoracic impedance component is a transthoracic impedance sensor that measures the impedance of the thorax region using a 2-electrode system.These 2 electrodes can be placed across the chest, as shown in the Figure 1c.The thoracic impedance sensor was developed using an AD5933 integrated circuit (IC) from analog devices [33].
The AD5933 is a 12-bit impedance analyzer that sends an AC voltage at a programmable frequency [33].This voltage can be used to measure unknown impedances.In the case of a two-electrode thoracic impedance system, one electrode is used as an input electrode to send the AC voltage, and the other electrode is used as the output electrode to measure the output voltage.The change in the voltage can be measured to show the impedance of the path between the input and output electrodes.The signal from the AD5933 is very weak and, therefore, requires signal amplification and filtration using the analog front end (AFE), as show in Figure 1d.The AFE is based on an active high-pass filter to filter any DC components, followed by an operational amplifier to form voltage-controlled current source (VCCS) and instrumentation amplifier.The VCCS injects a constant current into the thoracic region to create a potential difference in that region.This potential difference is measured using an instrumentation amplifier and then sent back to the AD5933 to calculate the thoracic impedance based on the generated current and the potential created by the current.Figure 1e shows the circuit of the thoracic impedance sensor consisting of the AD5933 and the AFE.
The MAX30101 measures the HR and SPO2 using a photoplethysmography (PPG) technique in which an LED with an infrared ray (IR) shines over the arterial periphery to measure the absorption of the input ray [29].The amount of absorbed light provides the HR and SPO2.The ADXL 362 is a tri-axial accelerometer for measuring static and dynamic accelerations and is used to detect the activity whenever there is significant motion by the subject [30].The ADXL 362 can be programmed with activity and inactivity thresholds in terms of codes for the purpose of defining the activity.Whenever the acceleration of the subject is higher than the activity threshold, the accelerometer will register it as an activity.For this purpose, we defined our activity threshold with 300 codes at a default output data rate (ODR) of 100 Hz.This activity threshold was found to be sensitive enough to detect the transition of the subject from a resting to active condition.In the wearable sensor we used binary states for activity, where 1 indicates an active state and 0 indicates an inactive state.These sensors are integrated with the Arduino MKR 1010, and the data are sent to Google Firebase.In this cloud-based database, a Wi-Fi-based mobile application, developed using JavaScript, reads data for the patients and the medical practitioner, which can be viewed in separate portals [34,35].The code for the device and data transmission to Google Firebase can be found written in the Arduino IDE (see Supplementary Material Section S1).The program for the wearable is an effective program that consumes only 62,100 bytes, constituting only 23% of the total flash memory of the microcontroller with 32 kilobytes (KB) of static RAM (SRAM) [34].The device is powered using a small 3.7 V battery with a 1300 mAh capacity.The device consumes 72.35 mA and, therefore, can run on the battery for approximately 18 h.The device was evaluated on subjects of varying biometric and anatomical structures, the results of which are discussed in the subsequent sections.
IoT 2024, 5, FOR PEER REVIEW 4 developed using JavaScript, reads data for the patients and the medical practitioner, which can be viewed in separate portals [34,35].The code for the device and data transmission to Google Firebase can be found wri en in the Arduino IDE (see Supplementary Material Section S1).The program for the wearable is an effective program that consumes only 62,100 bytes, constituting only 23% of the total flash memory of the microcontroller with 32 kilobytes (KB) of static RAM (SRAM) [34].The device is powered using a small 3.7 V ba ery with a 1300 mAh capacity.The device consumes 72.35 mA and, therefore, can run on the ba ery for approximately 18 h.The device was evaluated on subjects of varying biometric and anatomical structures, the results of which are discussed in the subsequent sections.

Skin Patch
Along with the body-mounted sensor, we also developed a skin patch by transforming the body-mounted sensor using a flexible PCB, as shown in Figure 2. The skin patch sensor is also an IoT device with the same circuitry but on a flexible PCB which makes it much lighter and more flexible than the body-mounted sensor.Additionally, the skin patch sensor does not have electrode leads wires like the body-mounted sensor and instead connects electrode pads for the thoracic impedance sensor using snap connectors.

Skin Patch
Along with the body-mounted sensor, we also developed a skin patch by transforming the body-mounted sensor using a flexible PCB, as shown in Figure 2. The skin patch sensor is also an IoT device with the same circuitry but on a flexible PCB which makes it much lighter and more flexible than the body-mounted sensor.Additionally, the skin patch sensor does not have electrode leads wires like the body-mounted sensor and instead connects electrode pads for the thoracic impedance sensor using snap connectors.This provides much more compliance when using the sensor and removes any noncompliance due to the electrode lead wires.
IoT 2024, 5, FOR PEER REVIEW 5 This provides much more compliance when using the sensor and removes any noncompliance due to the electrode lead wires.

Experimentation
This section will discuss the calibration of the transthoracic impedance sensor, as well as the results of the evaluation of the device on different subjects.The protocol of the experiment is explained in Table 1.The aforementioned vitals of 10 different subjects (6 females and 4 males) were recorded using the device in three different conditions-si ing, standing, and walking-each for 20 min.This was done to evaluate the performance of the device in real-time conditions and for longer periods.All experiments were conducted with the approval of the Institutional Review Board (IRB) from Florida Atlantic University (FAU).For each subject, an account was created in the mobile application with their biometric information, including age, height, and weight.This information is summarized in Table 2.After registration, subjects were asked to sit for 20 min, during which their vitals were recorded and viewed in the mobile application.Similarly, subjects were asked to stand and walk for the next 20 min each.

Experimentation
This section will discuss the calibration of the transthoracic impedance sensor, as well as the results of the evaluation of the device on different subjects.The protocol of the experiment is explained in Table 1.The aforementioned vitals of 10 different subjects (6 females and 4 males) were recorded using the device in three different conditions-sitting, standing, and walking-each for 20 min.This was done to evaluate the performance of the device in real-time conditions and for longer periods.All experiments were conducted with the approval of the Institutional Review Board (IRB) from Florida Atlantic University (FAU).For each subject, an account was created in the mobile application with their biometric information, including age, height, and weight.This information is summarized in Table 2.After registration, subjects were asked to sit for 20 min, during which their vitals were recorded and viewed in the mobile application.Similarly, subjects were asked to stand and walk for the next 20 min each.Sitting 20

Thoracic Impedance Activity Status HR SPO2
Standing 20

Thoracic Impedance Activity Status HR SPO2
Walking 20

Thoracic Impedance Sensor Calibration
The thoracic impedance sensor measures the unknown impedance with reference to the calibration using a known impedance [33,36].The calibration provides a gain factor that is used to measure the unknown impedance.The known impedance is chosen based on its relevance with the unknown impedance.For this purpose, we chose an RC circuit, as shown in Figure 3a, as it resembles the thorax region [37].As the thoracic region responds to frequencies between 1 and 100 K, therefore, we programmed the thoracic impedance sensor at 50 KHz (a commonly used frequency for monofrequency thoracic impedance systems) with V out set to be 2V pk-pk.The values from the sensor were co-related with the standard LCR meter (E4980AL Precision LCR Meter by Keysight Technologies, US) [38].An equation based on this relationship, as shown in Figure 3b, is used as a gain factor for the unknown impedances.We evaluated the performance of the thoracic impedance sensor by performing respiratory experiments.During inhalation, the air fills the thorax region, and because air is more resistive, it increases the amplitude of the thoracic impedance.This can be seen in Figure 3c.This signal is further processed with normalization and smoothening techniques to obtain a clean signal, as shown in Figure 3d.Moreover, the high-frequency components are removed using empirical mode decomposition [39].The final signal with respiration peaks is shown in Figure 3e.The frequency spectrum of the cleaned signal is shown in Figure 3f, which shows frequencies of less than 0.5 Hz.It can be seen in the inset plot that the major peak was at 0.16 Hz, which is the frequency of the respiration signal [40].

Results
The required parameters were recorded for one hour using the protocol mentioned in Table 1.The biometric information of the subjects is shown in Table 2.All subjects were in the age range of 24-31 years.As the experiments were performed on healthy subjects, therefore, we averaged the healthy ranges of these parameters and ignored outliers to avoid any noise in the parameters.For this purpose, the impedance values outside the thoracic impedance range of 70-1120 were filtered to avoid outliers due to skin resistance or loose contact of the electrode pads.Similarly, HR and SPO2 were preprocessed within 60-120 and >95%, respectively.The values outside this range are because of the uneven contact of the optical sensor with the skin.

Results
The required parameters were recorded for one hour using the protocol mentioned in Table 1.The biometric information of the subjects is shown in Table 2.All subjects were in the age range of 24-31 years.As the experiments were performed on healthy subjects, therefore, we averaged the healthy ranges of these parameters and ignored outliers to avoid any noise in the parameters.For this purpose, the impedance values outside the thoracic impedance range of 70-1120 were filtered to avoid outliers due to skin resistance or loose contact of the electrode pads.Similarly, HR and SPO2 were preprocessed within 60-120 and >95%, respectively.The values outside this range are because of the uneven contact of the optical sensor with the skin.
Figure 4 shows the vitals of a subject in different real-time conditions of si ing, standing, and walking.The change in binary state for activity status in Figure 4b, from resting (si ing and standing) to walking, represents the change in the status of activity of the subject.The average values of all subjects' vitals under the three different conditions are also shown in Table 3, whereas the raw data for all subjects are given in the Supplementary Information Section S2. Figure 5 shows the average values of the vitals for different subjects under the three different conditions.It can be seen in Figure 5b that, on average, males had a higher thoracic impedance than females, where blue, orange and grey boxplots represent three different conditions si ing, standing and walking.This is because of the difference in the body-to-weight index, defined as shown in Equation ( 1) [41].The male volunteers had higher BMIs compared to the female volunteers, as is also evident from their biometric information in Table 2.An increased BMI increases the resistivity of the subject and, hence, the thoracic impedance of the thoracic region, according to Figure 4 shows the vitals of a subject in different real-time conditions of sitting, standing, and walking.The change in binary state for activity status in Figure 4b, from resting (sitting and standing) to walking, represents the change in the status of activity of the subject.The average values of all subjects' vitals under the three different conditions are also shown in Table 3, whereas the raw data for all subjects are given in the Supplementary Information Section S2. Figure 5 shows the average values of the vitals for different subjects under the three different conditions.It can be seen in Figure 5b that, on average, males had a higher thoracic impedance than females, where blue, orange and grey boxplots represent three different conditions sitting, standing and walking.This is because of the difference in the body-to-weight index, defined as shown in Equation ( 1) [41].The male volunteers had higher BMIs compared to the female volunteers, as is also evident from their biometric information in Table 2.An increased BMI increases the resistivity of the subject and, hence, the thoracic impedance of the thoracic region, according to Equation (2) [42,43].Similarly, Figure 5c,d show the average SPO2 and HR for the subjects.As expected, on average, the HRs in the resting conditions (i.e., sitting and standing) were lower than the condition in which the subject was walking, as shown in Figure 5e.
where p is the resistivity region, L is the length, and A is the cross-sectional area of the region.The same experimentation was performed with a healthy subject (S1), the results of which are shown in Figure 6, using the skin patch to measure vital parameters.Figure 6 shows the parameter results of the subject using the skin patch.It can be seen that similar results were obtained for the subject, using the skin patch, from the body-mounted sensor, except that the magnitude of the thoracic impedance of the subject was lower than the magnitude of the thoracic impedance of the subject using the body-mounted sensor.This is because of the decrease in the distance between the electrode pads in the skin patch due to the snap connectors, which essentially represent the length of the area for which the impedance is measured.As the length of the region under consideration has decreased therefore according to Equation (2) its magnitude will also decrease, keeping other factors constant.Moreover, similar results for the rest of the parameters were obtained in which the activity status transitions accordingly from not active to an active state in resting to walking conditions, and the HR along with SPO2 were in the expected ranges of 60-100 bpms and >95%, respectively, as well.The same experimentation was performed with a healthy subject (S1), the results of which are shown in Figure 6, using the skin patch to measure vital parameters.Figure 6 shows the parameter results of the subject using the skin patch.It can be seen that similar results were obtained for the subject, using the skin patch, from the body-mounted sensor, except that the magnitude of the thoracic impedance of the subject was lower than the magnitude of the thoracic impedance of the subject using the body-mounted sensor.This is because of the decrease in the distance between the electrode pads in the skin patch due to the snap connectors, which essentially represent the length of the area for which the impedance is measured.As the length of the region under consideration has decreased therefore according to Equation (2) its magnitude will also decrease, keeping other factors constant.Moreover, similar results for the rest of the parameters were obtained in which the activity status transitions accordingly from not active to an active state in resting to walking conditions, and the HR along with SPO2 were in the expected ranges of 60-100 bpms and >95%, respectively, as well.The same experimentation was performed with a healthy subject (S1), the results which are shown in Figure 6, using the skin patch to measure vital parameters.Figure shows the parameter results of the subject using the skin patch.It can be seen that simil results were obtained for the subject, using the skin patch, from the body-mounted senso except that the magnitude of the thoracic impedance of the subject was lower than t magnitude of the thoracic impedance of the subject using the body-mounted sensor.Th is because of the decrease in the distance between the electrode pads in the skin patch d to the snap connectors, which essentially represent the length of the area for which t impedance is measured.As the length of the region under consideration has decreas therefore according to Equation ( 2) its magnitude will also decrease, keeping other facto constant.Moreover, similar results for the rest of the parameters were obtained in whi the activity status transitions accordingly from not active to an active state in resting walking conditions, and the HR along with SPO2 were in the expected ranges of 60-1 bpms and >95%, respectively, as well.

Discussion
A novel body-mounted wearable sensor has been developed to monitor vital parameters related to HF management.The device is an IoT device that monitors parameters related to HF and communicates them over Wi-Fi, whereby the parameters can be visualized in a mobile application.The device was evaluated in real-life conditions, where it was found to successfully measure these vitals in real time and continuously.The device consists of different sensors, including a thoracic impedance sensor, an optical sensor for HR and SPO2, and an accelerometer for activity status.The thoracic impedance sensor was built using the AD5933 impedance analyzer, and thoracic impedance was measured using an AFE.The thoracic impedance sensor's performance was validated using a standard respiration test, whereby the thoracic impedance increased in the presence of inspiration.Furthermore, the device was then evaluated on 10 different subjects, whereby their vitals were recorded for 1 h under different real-life conditions, namely, sitting, standing, and walking.
It was observed that, on average, males have higher thoracic impedance than females, and the resting HRs of the subjects were lower than their HR during walking.Similarly, the device successfully kept track of the activity status of the subjects.The device is a small 70 × 45 mm 2 compact sensor that can be mounted on the chest with two electrodes across the thorax.The device has the potential to be made into an electronic skin (e-skin), and we showed one possibility of this by making it over a flexible PCB.This will further reduce the size and height of the device.
The device can be used as a telehealth monitor when connected with a cloud database and a Wi-Fi-based mobile application.The mobile application has different portals for medical practitioners and patients, protected with their username and password, as shown in Figure 7 [44].With the increasing economic burden of cardiovascular diseases, especially HF, telehealth monitoring may help to reduce hospital visits and increase the accessibility of patients' vital parameters.This noninvasive sensor is a novel device that can help patients and providers manage HF with real-time monitoring.Multiparametric analysis allows for better specificity and sensitivity toward disease diagnostics [45].Thoracic impedance alone has been found to have a sensitivity of 62% and a prognostic ability to detect heart failure, on average, 18 days before it occurs [45,46].This proposed multiparametric device measures thoracic impedance along with other vital parameters that can improve management of HF using a telemedicine system.Recent efforts have been made to monitor HF using wearable devices.For example, a wearable vest has been developed to monitor transthoracic impedance along with ECG [23,47].However, unlike the device proposed in this paper, it can only be used with the patient at rest.Similarly, a body-mounted sensor has also been developed to monitor HF using time synchronized vibrations, but it is not recommended to use while performing daily tasks [24,48].Therefore, the device proposed in this article has the ability to measure parameters important in monitoring HF, continuously and in real-time conditions to better understand HF progression.

Conclusions
In this paper, we discussed the development and evaluation of a noninvasive IoT wearable device that measures vitals related to HF, namely, thoracic impedance, HR, SPO2, and activity status.The device conveniently a aches to the chest using a medicalgrade double-sided adhesive (DSA) and measures vitals continuously in real time.These

Conclusions
In this paper, we discussed the development and evaluation of a noninvasive IoT wearable device that measures vitals related to HF, namely, thoracic impedance, HR, SPO2, and activity status.The device conveniently attaches to the chest using a medical-grade double-sided adhesive (DSA) and measures vitals continuously in real time.These vitals are stored in a cloud database and visualized using a Wi-Fi-based mobile application.The device was validated by recording vitals for 1 h in 10 different subjects in sitting, standing, and walking conditions.The device was able to successfully record process the monitored data in the expected ranges.We also report an extended version of the body-mounted sensor, a flexible skin patch, which is more lightweight and patient compliant than the body-mounted sensor, with a comparable performance as that of the body-mounted sensor.

Figure 1 .
Figure 1.(a) Body-mounted sensor; (b) body-mounted sensor with transthoracic impedance electrodes (E1 and E2); (c) placement of the wearable device and electrodes on the thorax region; (d) schematic of the transthoracic impedance sensor; (e) printed circuit board for the transthoracic impedance sensor.

Figure 1 .
Figure 1.(a) Body-mounted sensor; (b) body-mounted sensor with transthoracic impedance electrodes (E1 and E2); (c) placement of the wearable device and electrodes on the thorax region; (d) schematic of the transthoracic impedance sensor; (e) printed circuit board for the transthoracic impedance sensor.

Figure 3 .
Figure 3. (a) Circuit diagram for the calibration of the transthoracic impedance sensor; (b) fit line equation for calibrating the transthoracic impedance sensor; (c) raw signal of the transthoracic impedance during inspiration; (d) normalized and smoothed signal; (e) clean signal along with the original and smoothed signal highlighting a change in the transthoracic impedance during inspiration; (f) frequency response of the transthoracic impedance signal.

Figure 3 .
Figure 3. (a) Circuit diagram for the calibration of the transthoracic impedance sensor; (b) fit line equation for calibrating the transthoracic impedance sensor; (c) raw signal of the transthoracic impedance during inspiration; (d) normalized and smoothed signal; (e) clean signal along with the original and smoothed signal highlighting a change in the transthoracic impedance during inspiration; (f) frequency response of the transthoracic impedance signal.

Figure 4 .
Figure 4. (a) Average transthoracic impedance of a subject in the different conditions; (b) activity status of a subject in the different conditions; (c) average heart rate of a subject in the different conditions; (d) average SPO2 of a subject in the different conditions.

Figure 4 .
Figure 4. (a) Average transthoracic impedance of a subject in the different conditions; (b) activity status of a subject in the different conditions; (c) average heart rate of a subject in the different conditions; (d) average SPO2 of a subject in the different conditions.

Figure 5 .
Figure 5. (a) Average transthoracic impedance while si ing, standing, and walking; (b) average transthoracic impedance vs. gender; (c) average SPO2 while si ing, standing, and walking; (d) average heart rate for subjects while si ing, standing, and walking; (e) average heart rate in three different conditions.

Figure 5 .
Figure 5. (a) Average transthoracic impedance while sitting, standing, and walking; (b) average transthoracic impedance vs. gender; (c) average SPO2 while sitting, standing, and walking; (d) average heart rate for subjects while sitting, standing, and walking; (e) average heart rate in three different conditions.

Figure 5 .
Figure 5. (a) Average transthoracic impedance while si ing, standing, and walking; (b) avera transthoracic impedance vs. gender; (c) average SPO2 while si ing, standing, and walking; (d) a erage heart rate for subjects while si ing, standing, and walking; (e) average heart rate in three d ferent conditions.

Figure 6 .
Figure 6.(a) Average transthoracic impedance of a subject while sitting; (b) activity status of a subject while sitting; (c) average heart rate of a subject while sitting; (d) average SPO2 of a subject while sitting.

IoT 2024, 5 , 11 Figure 7 .
Figure 7. (a) Mobile application sign-in page; (b) mobile application registration page; (c) heart rate of a subject; (d) activity status of a subject; (e) SPO2 of a subject; (f) transthoracic impedance of a subject while walking.

Figure 7 .
Figure 7. (a) Mobile application sign-in page; (b) mobile application registration page; (c) heart rate of a subject; (d) activity status of a subject; (e) SPO2 of a subject; (f) transthoracic impedance of a subject while walking.

Table 1 .
Experimental protocol for recording vitals.

Table 1 .
Experimental protocol for recording vitals.

Table 2 .
Biometric information of subjects.

Table 3 .
Average values of the vitals for subjects in different conditions.