Ultrasonographic Findings in Common Thyroid and Parathyroid Disorders—Advantages of Real Time Observation by the Endocrinologist with their Own Ultrasound Machine

: In this review we discuss the signiﬁcance of the main ultrasonographic features of common thyroid and parathyroid conditions, with a focus on the advantages of real time observation. The thyroid specialist, deﬁned as an endocrinologist with a major interest in thyroid disorders and access to a portable ultrasound machine, can correlate what they see with the thyroid blood test results and clinical ﬁndings in a way that is not available to the general endocrinologist who relies on the interpretation by the consultant radiologist of ultrasound images prepared by a technician. We also discuss the signiﬁcance of the small, very bright, intra nodular microcalciﬁcations found in benign colloid nodules, which we call “colloid spots” and the difference between these and the 3–4 mm soft microcalciﬁcations that are 90% speciﬁc for papillary thyroid cancer and provide a new system for staging the inﬂammatory changes in Hashimoto thyroiditis, as observed on ultrasonography.


Introduction
Thyroid ultrasonography has become a routine tool for the endocrinologist in the diagnosis and management of thyroid and parathyroid disorders [1,2]. However, it is now clear that the thyroid specialist ("thyroidologist") with a portable ultrasound machine is in the best position to correlate the features of thyroid nodules and other thyroid disorders with the clinical findings and blood test results. In addition, the thyroid specialist can provide "one stop shopping" for their patients as they also perform their own fine needle aspiration biopsies (FNAB) of suspicious nodules.
In this review we describe the ultrasound features of the common types of thyroid disorders, how to correctly interpret what is seen, when to repeat the imaging and when to carry out FNAB of suspicious nodules. We will describe some newly recognised features of thyroid sonograms and briefly discuss the sonographic appearances of parathyroid adenomas, the usual cause of primary hyperparathyroidism. The purpose of the review is to provide an understanding of the utility of real time thyroid, parathyroid and neck ultrasound for the aspiring thyroid specialist, its scope in the office and how can it help in the patient's management. All figures are derived from one of the authors' (JW) own patients and were obtained using his M-Tubo Sonosite portable ultrasound machine and a 5 MHZ small parts transducer.

Figure 1.
Right lobe of the thyroid gland of a 34-year-old female with no personal or family history of thyroid disease. The gland is of "normal size" and the texture throughout is described as "isoechoic".

Nodules
Thyroid nodules are very common, increasing to a prevalence of about 60% in adult women aged 60 or more. Most benign nodules are "colloid" according to the dominant presence of fluid and few cells (low cell:fluid ratio), i.e., the nodule comprises scattered normal thyroid follicular cells within a background of thick, viscous fluid [4]. Although the prevalence of cancer is about 8% in patients with one or more nodules, the risk of cancer is greater in patients with a single nodule since multi nodular, or colloid, goitre is a benign disease and all of the nodules are expected to be the same, differing only in size. A micro cancer incidentally found in a multi nodular can be considered to be an incidentaloma that would not have harmed the patient if left alone. An example of a benign colloid nodule with a sharp edge, halo (a black ring thought to represent compressed blood vessels) and isogenic texture, which is <3 cm and wider than tall, is shown in Figure 2. Right lobe of the thyroid gland of a 34-year-old female with no personal or family history of thyroid disease. The gland is of "normal size" and the texture throughout is described as "isoechoic".
The texture of the normal thyroid texture, or echogenicity, as determined using the ultrasound grey scale, is described as isogenous or isoechoic. Features of an abnormal gland, such as cysts or nodules, that are less white than normal, ranging from grey through to black, are described as being variably hypoechoic. Some nodules and areas of inflammation that are whiter than normal are described as being hyperechoic. Thyroid cysts, which are fluid-containing sacs, and the "black holes" of end stage Hashimoto thyroiditis, are uniformly black. Benign colloid nodules are usually isoechoic or slightly hypoechoic, whilst more cellular follicular nodules may be slightly hyperechoic. The ability to recognize variations in the echogenicity of the thyroid gland itself and nodules, cysts or infiltrations within the gland can only be obtained by extensive, long term experience, even surpassing that of the general radiologist.
Another feature of the thyroid gland to be assessed is its vascularity. The normal vascularity of the thyroid reflects the distribution of the thyroid arteries and veins, which will vary from subject to subject and include several anatomical variations, all of which are "normal", and the overall blood flow into and out of the gland.
In Graves' hyperthyroidism, the overall blood supply is greatly increased due to the diffuse and intense inflammatory reaction, whereas in Hashimoto thyroiditis, the blood supply to the thyroid is initially increased when the inflammatory reaction is active, then decreases as the gland is progressively destroyed over time and replaced by fibrosis and scarring. Abnormalities of the blood supply in the various thyroid disorders will be discussed in more detail below.

Nodules
Thyroid nodules are very common, increasing to a prevalence of about 60% in adult women aged 60 or more. Most benign nodules are "colloid" according to the dominant presence of fluid and few cells (low cell:fluid ratio), i.e., the nodule comprises scattered normal thyroid follicular cells within a background of thick, viscous fluid [4]. Although the prevalence of cancer is about 8% in patients with one or more nodules, the risk of cancer is greater in patients with a single nodule since multi nodular, or colloid, goitre is a benign disease and all of the nodules are expected to be the same, differing only in size. A micro cancer incidentally found in a multi nodular can be considered to be an incidentaloma that would not have harmed the patient if left alone. An example of a benign colloid nodule with a sharp edge, halo (a black ring thought to represent compressed blood vessels) and isogenic texture, which is <3 cm and wider than tall, is shown in Figure 2. Right lobe of the thyroid gland of a 34-year-old female with no personal or family history of thyroid disease. The gland is of "normal size" and the texture throughout is described as "isoechoic".

Nodules
Thyroid nodules are very common, increasing to a prevalence of about 60% in adult women aged 60 or more. Most benign nodules are "colloid" according to the dominant presence of fluid and few cells (low cell:fluid ratio), i.e., the nodule comprises scattered normal thyroid follicular cells within a background of thick, viscous fluid [4]. Although the prevalence of cancer is about 8% in patients with one or more nodules, the risk of cancer is greater in patients with a single nodule since multi nodular, or colloid, goitre is a benign disease and all of the nodules are expected to be the same, differing only in size. A micro cancer incidentally found in a multi nodular can be considered to be an incidentaloma that would not have harmed the patient if left alone. An example of a benign colloid nodule with a sharp edge, halo (a black ring thought to represent compressed blood vessels) and isogenic texture, which is <3 cm and wider than tall, is shown in Figure 2. Thyroid ultrasound from a patient with a nodule that was shown to be benign on biopsy. The nodule is isogenic, wider than tall, with a sharp edge and halo. Figure 2. Thyroid ultrasound from a patient with a nodule that was shown to be benign on biopsy. The nodule is isogenic, wider than tall, with a sharp edge and halo. Some intra nodular "microcalcifications" are actually colloid, which may be lined up like a comet tail or dispersed around the inner edge of the nodule ( Figure 3). Others, brighter and sharper, are probably colloid crystals. In many nodules there is a single bright spot, often at one side of the nodule, like a nucleus of a cell, that might be the source of the colloid fluid, that could be called a "colloidoma". Although radiologists describe these as "microcalcifications"-implying suspicion for papillary thyroid cancer-this is probably not correct as, in the authors' experience, they are quite different from the microcalcifications of papillary thyroid cancer. Finally, some of these colloid bright spots may represent what has been called "the ring down resonance artifact". Overall, our experience suggests that colloid bright spots are mislabelled as microcalcifications in approximately 30% of cases. these as "microcalcifications"-implying suspicion for papillary thyroid cancer-t probably not correct as, in the authors' experience, they are quite different from microcalcifications of papillary thyroid cancer. Finally, some of these colloid bright may represent what has been called "the ring down resonance artifact". Overall experience suggests that colloid bright spots are mislabelled as microcalcificatio approximately 30% of cases. Figure 3. A benign nodule with a series of bright intramodular microcalcifications (arrow). Th spots need to be differentiated from the larger softer (less bright) microcalcifications which ar often found in papillary thyroid cancer.

Follicular Nodules
Follicular nodules are much less common than colloid nodules with a diff appearance on ultrasound; they are more cellular, giving a solid appearance, w whitish colour, i.e., less hypoechoic. They too have a sharp edge and halo and grow sl over time [5]. The problem with these lesions is that FNAB is unable to differen between a benign follicular adenoma and follicular cancer, and if the latter is suspe thyroid surgery is the final arbitrator. About 10% of benign thyroid nodules are follic and most of them end up being removed. Two examples of follicular nodules that finally proven to be benign are shown in Figure 4. On follow-up ultrasound (US), months later, repeat biopsy might be indicated if a nodule has grown by 20% or mo two or more dimensions; benign nodules also grow, but less quickly.

Follicular Nodules
Follicular nodules are much less common than colloid nodules with a different appearance on ultrasound; they are more cellular, giving a solid appearance, with a whitish colour, i.e., less hypoechoic. They too have a sharp edge and halo and grow slowly over time [5]. The problem with these lesions is that FNAB is unable to differentiate between a benign follicular adenoma and follicular cancer, and if the latter is suspected, thyroid surgery is the final arbitrator. About 10% of benign thyroid nodules are follicular, and most of them end up being removed. Two examples of follicular nodules that were finally proven to be benign are shown in Figure 4. On follow-up ultrasound (US), 6-12 months later, repeat biopsy might be indicated if a nodule has grown by 20% or more in two or more dimensions; benign nodules also grow, but less quickly.

Hot Nodules
Nodules shown to be "hot" or "toxic" on technetium scan are "never" cancerous as they are at least partially differentiated, in other words, producing thyroid hormones. It is however sometimes appropriate to carry out FNAB in order to reassure the patient and confirm the benign nature of the nodule. On occasion, hot nodules may contain fluid on biopsy, but on needling the nodule, a cellular specimen is obtained, as in the case of the example shown in Figure 5. The appearance of toxic nodules varies, but they are usually . Two examples of follicular nodules that were shown at surgery to be benign. The nodules are roughly oval shaped, slightly hyper echoic and have sharp edges and, particularly, the bigger of the two, thick halos.

Hot Nodules
Nodules shown to be "hot" or "toxic" on technetium scan are "never" cancerous as they are at least partially differentiated, in other words, producing thyroid hormones. It is however sometimes appropriate to carry out FNAB in order to reassure the patient and confirm the benign nature of the nodule. On occasion, hot nodules may contain fluid on biopsy, but on needling the nodule, a cellular specimen is obtained, as in the case of the example shown in Figure 5. The appearance of toxic nodules varies, but they are usually similar to the colloid nodules. Occasionally they are markedly hypoechoic, or cystic, as in this case. . Two examples of follicular nodules that were shown at surgery to be benign. The nodules are roughly oval shaped, slightly hyper echoic and have sharp edges and, particularly, the bigger of the two, thick halos.

Hot Nodules
Nodules shown to be "hot" or "toxic" on technetium scan are "never" cancerous as they are at least partially differentiated, in other words, producing thyroid hormones. It is however sometimes appropriate to carry out FNAB in order to reassure the patient and confirm the benign nature of the nodule. On occasion, hot nodules may contain fluid on biopsy, but on needling the nodule, a cellular specimen is obtained, as in the case of the example shown in Figure 5. The appearance of toxic nodules varies, but they are usually similar to the colloid nodules. Occasionally they are markedly hypoechoic, or cystic, as in this case. Figure 5. Thyroid nodule in a patient with hyperthyroidism shown, from technetium uptake and scan, to be "hot" or "toxic".

Thyroid Cysts
Thyroid cysts are important because it may be possible to relieve the patient's neck symptoms by removing the fluid. However, a cyst tends to refill, which can be a sign that it has a solid component which, in about 10% of cases, is cancerous [6]. Sometimes it is difficult to differentiate a cyst from a hyperechoic colloid or "toxic" nodule, even after biopsy, since fluid may be drawn off from both lesions. Both may look hypoechoic (black) but a cyst is usually larger and more round, somewhat blacker and has a thin, sharp edge, as shown in Figure 6. The cyst has a specific feel on palpation (whereas a colloid nodule, where palpable, feels firm, even hard) and, if tested for, is translucent. Cysts may have a Figure 5. Thyroid nodule in a patient with hyperthyroidism shown, from technetium uptake and scan, to be "hot" or "toxic".

Thyroid Cysts
Thyroid cysts are important because it may be possible to relieve the patient's neck symptoms by removing the fluid. However, a cyst tends to refill, which can be a sign that it has a solid component which, in about 10% of cases, is cancerous [6]. Sometimes it is difficult to differentiate a cyst from a hyperechoic colloid or "toxic" nodule, even after biopsy, since fluid may be drawn off from both lesions. Both may look hypoechoic (black) but a cyst is usually larger and more round, somewhat blacker and has a thin, sharp edge, as shown in Figure 6. The cyst has a specific feel on palpation (whereas a colloid nodule, where palpable, feels firm, even hard) and, if tested for, is translucent. Cysts may have a solid component whose echogenicity may be hypo or hyper echoic, sometimes only seen after removal of the fluid.

Oncocytic Nodules
About 10% of thyroid nodules contain a predominance of oncocytes, or Hürthle cells, which are characterised from their eosinophilic granular cytoplasm, vesicular nucleus and large nucleolus. A Hürthle cell is larger than a follicular cell, and its cellular material stains

Oncocytic Nodules
About 10% of thyroid nodules contain a predominance of oncocytes, or Hürthle cells, which are characterised from their eosinophilic granular cytoplasm, vesicular nucleus and large nucleolus. A Hürthle cell is larger than a follicular cell, and its cellular material stains pink with ethanol fixed haematoxylin-eosin stain. These cells can also be identified and enumerated in Papanicolaou-stained smears or with air-dried Romanowsky stain. Hürthle cells are also seen in Hashimoto thyroiditis and in association with benign nodules. An oncocytic tumour comprises 70% or more oncocytes and is shown at surgery to be benign in 90% of cases and malignant in 10% of cases. An example of a benign oncocytic adenoma is seen in Figure 7.

Oncocytic Nodules
About 10% of thyroid nodules contain a predominance of oncocytes, or Hürthle cell which are characterised from their eosinophilic granular cytoplasm, vesicular nucleus an large nucleolus. A Hürthle cell is larger than a follicular cell, and its cellular material stain pink with ethanol fixed haematoxylin-eosin stain. These cells can also be identified an enumerated in Papanicolaou-stained smears or with air-dried Romanowsky stain Hürthle cells are also seen in Hashimoto thyroiditis and in association with benig nodules. An oncocytic tumour comprises 70% or more oncocytes and is shown at surger to be benign in 90% of cases and malignant in 10% of cases. An example of a benig oncocytic adenoma is seen in Figure 7. . This 20 mm hypoechoic nodule has a slightly irregular edge and is hypoechoic and thus considered suspicious for papillary cancer. However, biopsy showed that it was an oncocytic tumour and, following hemi-thyroidectomy and pathological examination, benign.

Calcification
The normal gland does not contain any calcification. The presence of calcification i association with nodules generally indicates that the nodules are long standing an therefore likely to be benign. However, breaks in the wall of a calcified nodule sugges that the nodule is a cancer which has invaded into the surrounding thyroid tissue and Figure 7. This 20 mm hypoechoic nodule has a slightly irregular edge and is hypoechoic and thus considered suspicious for papillary cancer. However, biopsy showed that it was an oncocytic tumour and, following hemi-thyroidectomy and pathological examination, benign.

Calcification
The normal gland does not contain any calcification. The presence of calcification in association with nodules generally indicates that the nodules are long standing and therefore likely to be benign. However, breaks in the wall of a calcified nodule suggest that the nodule is a cancer which has invaded into the surrounding thyroid tissue and is considered a suspicious feature of a nodule [7]. Calcification is sometimes seen as spots or sheets scattered throughout the thyroid. Calcification surrounding a thyroid nodule, giving it the appearance of a "bone ball", can be felt as a hard, mobile lump on neck palpation that is crunchy on biopsy. Chronic linear or egg shell calcification is associated with shadowing because the ultrasound waves are unable to pass through calcified tissue ( Figure 8A,B). Calcification is also seen in the thyroid of patients with chronic Hashimoto thyroiditis and Graves' disease.
sheets scattered throughout the thyroid. Calcification surrounding a thyroid nodule, giving it the appearance of a "bone ball", can be felt as a hard, mobile lump on neck palpation that is crunchy on biopsy. Chronic linear or egg shell calcification is associated with shadowing because the ultrasound waves are unable to pass through calcified tissue ( Figure 8A,B). Calcification is also seen in the thyroid of patients with chronic Hashimoto thyroiditis and Graves' disease.
(A) (B) Figure 8. In (A) linear calcification in the anterior aspect of a benign 15 mm nodule is seen as a curved bright hypoechoic shelf (arrow) that blocks the transmission of the ultrasound waves, so the nodule behind appears to be very hypoechoic, as in a cyst. In (B) is seen a small hypoechoic calcified nodule (upper arrow) and below it, a larger nodule with linear calcification in its anterior surface (lower arrow).

Vascularity
The blood supply to thyroid nodules is an important feature to be documented in the course of real time ultrasonography. There are three types of vascularity to be discussed. Firstly, the so-called hypoechoic halo surrounding a benign nodule is caused by compressed blood vessels which can be seen when the "colour" button is engaged. An example of this is seen in Figure 9A. Secondly, the degree of vascularity around the outside of a nodule is reflective of its activity and prominent blood supply around a nodule maybe a sign of thyroid cancer ( Figure 9B) [8] but can also be present around nodules shown by biopsy to be benign. It has recently been shown that blood vessels within a nodule, especially if it has other suspicious features ( Figure 9B), may be a reliable sign of cancer [9].
(A) (B) Figure 8. In (A) linear calcification in the anterior aspect of a benign 15 mm nodule is seen as a curved bright hypoechoic shelf (arrow) that blocks the transmission of the ultrasound waves, so the nodule behind appears to be very hypoechoic, as in a cyst. In (B) is seen a small hypoechoic calcified nodule (upper arrow) and below it, a larger nodule with linear calcification in its anterior surface (lower arrow).

Vascularity
The blood supply to thyroid nodules is an important feature to be documented in the course of real time ultrasonography. There are three types of vascularity to be discussed. Firstly, the so-called hypoechoic halo surrounding a benign nodule is caused by compressed blood vessels which can be seen when the "colour" button is engaged. An example of this is seen in Figure 9A. Secondly, the degree of vascularity around the outside of a nodule is reflective of its activity and prominent blood supply around a nodule maybe a sign of thyroid cancer ( Figure 9B) [8] but can also be present around nodules shown by biopsy to be benign. It has recently been shown that blood vessels within a nodule, especially if it has other suspicious features ( Figure 9B), may be a reliable sign of cancer [9]. palpation that is crunchy on biopsy. Chronic linear or egg shell calcification is associated with shadowing because the ultrasound waves are unable to pass through calcified tissue ( Figure 8A,B). Calcification is also seen in the thyroid of patients with chronic Hashimoto thyroiditis and Graves' disease.
(A) (B) Figure 8. In (A) linear calcification in the anterior aspect of a benign 15 mm nodule is seen as a curved bright hypoechoic shelf (arrow) that blocks the transmission of the ultrasound waves, so the nodule behind appears to be very hypoechoic, as in a cyst. In (B) is seen a small hypoechoic calcified nodule (upper arrow) and below it, a larger nodule with linear calcification in its anterior surface (lower arrow).

Vascularity
The blood supply to thyroid nodules is an important feature to be documented in the course of real time ultrasonography. There are three types of vascularity to be discussed. Firstly, the so-called hypoechoic halo surrounding a benign nodule is caused by compressed blood vessels which can be seen when the "colour" button is engaged. An example of this is seen in Figure 9A. Secondly, the degree of vascularity around the outside of a nodule is reflective of its activity and prominent blood supply around a nodule maybe a sign of thyroid cancer ( Figure 9B) [8] but can also be present around nodules shown by biopsy to be benign. It has recently been shown that blood vessels within a nodule, especially if it has other suspicious features ( Figure 9B), may be a reliable sign of cancer [9]. In Figure 10 is shown matching images of a benign nodule without (A) and with (B) blood flow in the halo around the nodule.

Thyroid Cancer
The thyroid specialist using their own portable US machine will, with experience, learn to recognize those characteristics of nodules which are suspicious for malignancy. These include taller than wide, indicating that the tumour is growing through, rather than along, the tissue planes; absence of a peripheral halo (compressed blood vessels in a benign nodule), the 3-4 mm "fluffy" intra nodular microcalcifications (actually psamoma bodies rather than true calcification), which are 90% specific for papillary cancer [1,2,10]; intra nodular hypervascularity, which is presumed to be feeding the cancer; and size > 3 cm.
Three examples of papillary thyroid cancer are shown here. Firstly, a large typical papillary cancer with the characteristic microcalcifications is seen in Figure 11.

Thyroid Cancer
The thyroid specialist using their own portable US machine will, with experience, learn to recognize those characteristics of nodules which are suspicious for malignancy. These include taller than wide, indicating that the tumour is growing through, rather than along, the tissue planes; absence of a peripheral halo (compressed blood vessels in a benign nodule), the 3-4 mm "fluffy" intra nodular microcalcifications (actually psamoma bodies rather than true calcification), which are 90% specific for papillary cancer [1,2,10]; intra nodular hypervascularity, which is presumed to be feeding the cancer; and size > 3 cm.
Three examples of papillary thyroid cancer are shown here. Firstly, a large typical papillary cancer with the characteristic microcalcifications is seen in Figure 11.
In Figure 10 is shown matching images of a benign nodule without (A) and with (B blood flow in the halo around the nodule.

Thyroid Cancer
The thyroid specialist using their own portable US machine will, with experience learn to recognize those characteristics of nodules which are suspicious for malignancy These include taller than wide, indicating that the tumour is growing through, rather than along, the tissue planes; absence of a peripheral halo (compressed blood vessels in a benign nodule), the 3-4 mm "fluffy" intra nodular microcalcifications (actually psamoma bodies rather than true calcification), which are 90% specific for papillary cancer [1,2,10] intra nodular hypervascularity, which is presumed to be feeding the cancer; and size > 3 cm.
Three examples of papillary thyroid cancer are shown here. Firstly, a large typica papillary cancer with the characteristic microcalcifications is seen in Figure 11.  . Thyroid ultrasound from a patient with confirmed papillary thyroid cancer. The nodule is large (3 cm) and hypoechoic with an indistinct irregular edge and central microcalcifications. The calcifications are softer (less white) than seen above in some benign nodules and larger, around 2-3 mm (arrow). There is no halo. Not seen here, the blood supply was increased in the lesion and there was a feeding vessel on one side of the lesion. Another example of macrocalcifications in papillary thyroid cancer. Secondly, a smaller but more hypoechoic lesion with obvious and larger soft microcalcifications and an irregular edge is shown in Figure 12. These two nodules are typical for papillary cancer and are reported from FNAB as "suspicious for papillary thyroid cancer". In both cases this was confirmed at thyroidectomy The calcifications are softer (less white) than seen above in some benign nodule around 2-3 mm (arrow). There is no halo. Not seen here, the blood supply was lesion and there was a feeding vessel on one side of the lesion. Another exampl macrocalcifications in papillary thyroid cancer.
Secondly, a smaller but more hypoechoic lesion with obvious microcalcifications and an irregular edge is shown in Figure 12. These typical for papillary cancer and are reported from FNAB as "suspic thyroid cancer". In both cases this was confirmed at thyroidectomy Thirdly, an example of a much smaller lesion that turned out to b is shown in Figure 13. The nodule is only 10-12 mm in size, hypoe unusual and irregular edge. Three years earlier the same lesion was se and its size then was 8 × 9 mm with no other suspicious features and no m nor feeding vessels or blood vessels, indicating that it had grown ve intervening 3 years. It was considered suspicious on ultrasound becaus edge. The lesion was shown to be suspicious for papillary cancer at FNA at hemi thyroidectomy. Thirdly, an example of a much smaller lesion that turned out to be papillary cancer is shown in Figure 13. The nodule is only 10-12 mm in size, hypoechoic and has an unusual and irregular edge. Three years earlier the same lesion was seen on ultrasound, and its size then was 8 × 9 mm with no other suspicious features and no microcalcifications nor feeding vessels or blood vessels, indicating that it had grown very little over the intervening 3 years. It was considered suspicious on ultrasound because of its shape and edge. The lesion was shown to be suspicious for papillary cancer at FNAB and confirmed at hemi thyroidectomy. The calcifications are softer (less white) than seen above in some benign nodules and larger, around 2-3 mm (arrow). There is no halo. Not seen here, the blood supply was increased in the lesion and there was a feeding vessel on one side of the lesion. Another example of macrocalcifications in papillary thyroid cancer.
Secondly, a smaller but more hypoechoic lesion with obvious and larger soft microcalcifications and an irregular edge is shown in Figure 12. These two nodules are typical for papillary cancer and are reported from FNAB as "suspicious for papillary thyroid cancer". In both cases this was confirmed at thyroidectomy Thirdly, an example of a much smaller lesion that turned out to be papillary cancer is shown in Figure 13. The nodule is only 10-12 mm in size, hypoechoic and has an unusual and irregular edge. Three years earlier the same lesion was seen on ultrasound, and its size then was 8 × 9 mm with no other suspicious features and no microcalcifications nor feeding vessels or blood vessels, indicating that it had grown very little over the intervening 3 years. It was considered suspicious on ultrasound because of its shape and edge. The lesion was shown to be suspicious for papillary cancer at FNAB and confirmed at hemi thyroidectomy. Figure 13. Small 10 mm nodule with an overall blurry irregular edge (arrow) that is taller than wide and hypoechoic, shown from FNAB to be papillary cancer. Figure 13. Small 10 mm nodule with an overall blurry irregular edge (arrow) that is taller than wide and hypoechoic, shown from FNAB to be papillary cancer.
It is not possible to differentiate the more common papillary cancer from the very much less common follicular neoplasms by ultrasound, although follicular lesions are more cellular and less hypoechoic and do not usually contain microcalcifications, the diagnosis being made at open biopsy.
On follow up after treatment, usually total thyroidectomy followed by radioiodine, one looks for abnormal lymph nodes in the neck, indicating local relapse. In the case of papillary carcinoma, involved nodes are round, hypo echoic and may contain microcalcifications ( Figure 14). They may have a cystic structure with posterior enhancement. It is recommended that the cervical lymph nodes be examined in all patients who undergo ultrasonography for whatever reason.
Reports 2021, 4, 8 10 It is not possible to differentiate the more common papillary cancer from the much less common follicular neoplasms by ultrasound, although follicular lesion more cellular and less hypoechoic and do not usually contain microcalcification diagnosis being made at open biopsy.
On follow up after treatment, usually total thyroidectomy followed by radioio one looks for abnormal lymph nodes in the neck, indicating local relapse. In the ca papillary carcinoma, involved nodes are round, hypo echoic and may co microcalcifications ( Figure 14). They may have a cystic structure with pos enhancement. It is recommended that the cervical lymph nodes be examined patients who undergo ultrasonography for whatever reason.

Graves' Hyperthyroidism
In Graves' hyperthyroidism, the gland is typically diffusely enlarged to a degre reflects the severity of the hyperthyroidism. Its vascularity is increased, dramatically, and is generalised. As the disease becomes chronic, e.g., after one or relapses post ant thyroid medication, the gland shrinks and becomes scarred and nod so called "nodular Graves' disease". However, it is not uncommon for patients Graves' disease to have incidental nodules, in which case the differential diagnosis follows: 1) Graves' disease which has become thickened and nodular due to its chron 2) Graves' disease with distinct nodules; and 3) Graves' disease with one or mor (toxic) nodules, i.e., two different diseases.
The blood supply in typical Graves' disease is diffusely increased (and assoc with a murmur), sometime up to 100 times normal, and the gland texture on ultras is usually heterogeneous (patchy) with a fine cystic appearance throughout, which re the diffuse nature of the inflammatory process ( Figure 15). Following radio io treatment, the normal gland architecture is disrupted because the follicles are destr and scar tissue predominates.

Graves' Hyperthyroidism
In Graves' hyperthyroidism, the gland is typically diffusely enlarged to a degree that reflects the severity of the hyperthyroidism. Its vascularity is increased, often dramatically, and is generalised. As the disease becomes chronic, e.g., after one or more relapses post ant thyroid medication, the gland shrinks and becomes scarred and nodular, so called "nodular Graves' disease". However, it is not uncommon for patients with Graves' disease to have incidental nodules, in which case the differential diagnosis is as follows: (1) Graves' disease which has become thickened and nodular due to its chronicity; (2) Graves' disease with distinct nodules; and (3) Graves' disease with one or more hot (toxic) nodules, i.e., two different diseases.
The blood supply in typical Graves' disease is diffusely increased (and associated with a murmur), sometime up to 100 times normal, and the gland texture on ultrasound is usually heterogeneous (patchy) with a fine cystic appearance throughout, which reflects the diffuse nature of the inflammatory process ( Figure 15). Following radio iodine treatment, the normal gland architecture is disrupted because the follicles are destroyed, and scar tissue predominates. (C) Figure 15. Thyroid ultrasound from two patients with Graves' hyperthyroidism. In (A) is shown an example of early Graves' hyperthyroidism manifest as multiple small inflammatory and lymphoid lesions, often described by the consultant radiologist as "nodules" blue arrow. In (B) is shown an enlarged thyroid, with a thick isthmus and a generalized patchy hypo echoicity due to the lymphocytic inflammation and thyroid cell proliferation. In (C) is shown the increased vascularity in the thyroid of the patient shown in (B).

Hashimoto Thyroiditis
Hashimoto thyroiditis is common, especially when diagnosed cytologically from biopsy of thyroid nodules, as an incidental finding, being demonstrated in 13.4% of a group of 811 patients [11]. The disease is approximately 10 times more common in females than males. Ultrasonography should be performed in all patients with Hashimoto thyroiditis to identify any nodules. Although not clearly established, it seems likely that there is an increased prevalence of cancer in patients with this chronic inflammatory condition compared to patients without nodules Ultrasonography is also useful in following individual patients with Hashimoto thyroiditis as an aid to management with thyroxine replacement [12] and to recognize the uncommon, but not rare, situation where Graves' hyperthyroidism changes ("flips") to Hashimoto thyroiditis [13].
As a result of the senior author's (JW) extensive experience of the ultrasound appearances of Hashimoto thyroiditis, he and his colleagues have developed a 5-stage classification of the inflammatory changes from early (stages 1, 2) through later (stages 3, 4, 5), as follows: Stage 1 is characterised by mild inflammatory changes manifest as small cystic lesions representing the lymphoid nodules and inflammatory infiltrations in a normal or slightly enlarged thyroid. In stage 2, the gland is enlarged and the cystic areas are better defined, more frequent and larger; the blood supply to the gland is increased in stages 1 and 2. In stage 3, the thyroid is generally bigger and the signs of inflammation increased with larger inflammatory nodules, and the blood supply is now patchy. In stage 4 the gland is becoming avascular, and the nodules are replaced by hypoechoic (black) spaces with scar tissue (fibrosis), and there are increased sheets of fibrosis, giving the appearance of pseudo nodules. In the final stage the gland is shrunken and scarred with absent blood supply and devoid of thyroid tissue [14]. Further uses of this classification system, such as the correlation between inflammation stage and the need for thyroxin replacement, are currently being addressed by the authors.
In Hashimoto thyroiditis the blood supply to the gland increases during the early inflammatory stages, but later, when the inflammation has burnt out and the gland is Figure 15. Thyroid ultrasound from two patients with Graves' hyperthyroidism. In (A) is shown an example of early Graves' hyperthyroidism manifest as multiple small inflammatory and lymphoid lesions, often described by the consultant radiologist as "nodules" blue arrow. In (B) is shown an enlarged thyroid, with a thick isthmus and a generalized patchy hypo echoicity due to the lymphocytic inflammation and thyroid cell proliferation. In (C) is shown the increased vascularity in the thyroid of the patient shown in (B).

Hashimoto Thyroiditis
Hashimoto thyroiditis is common, especially when diagnosed cytologically from biopsy of thyroid nodules, as an incidental finding, being demonstrated in 13.4% of a group of 811 patients [11]. The disease is approximately 10 times more common in females than males. Ultrasonography should be performed in all patients with Hashimoto thyroiditis to identify any nodules. Although not clearly established, it seems likely that there is an increased prevalence of cancer in patients with this chronic inflammatory condition compared to patients without nodules Ultrasonography is also useful in following individual patients with Hashimoto thyroiditis as an aid to management with thyroxine replacement [12] and to recognize the uncommon, but not rare, situation where Graves' hyperthyroidism changes ("flips") to Hashimoto thyroiditis [13].
As a result of the senior author's (JW) extensive experience of the ultrasound appearances of Hashimoto thyroiditis, he and his colleagues have developed a 5-stage classification of the inflammatory changes from early (stages 1, 2) through later (stages 3, 4, 5), as follows: Stage 1 is characterised by mild inflammatory changes manifest as small cystic lesions representing the lymphoid nodules and inflammatory infiltrations in a normal or slightly enlarged thyroid. In stage 2, the gland is enlarged and the cystic areas are better defined, more frequent and larger; the blood supply to the gland is increased in stages 1 and 2. In stage 3, the thyroid is generally bigger and the signs of inflammation increased with larger inflammatory nodules, and the blood supply is now patchy. In stage 4 the gland is becoming avascular, and the nodules are replaced by hypoechoic (black) spaces with scar tissue (fibrosis), and there are increased sheets of fibrosis, giving the appearance of pseudo nodules. In the final stage the gland is shrunken and scarred with absent blood supply and devoid of thyroid tissue [14]. Further uses of this classification system, such as the correlation between inflammation stage and the need for thyroxin replacement, are currently being addressed by the authors.
In Hashimoto thyroiditis the blood supply to the gland increases during the early inflammatory stages, but later, when the inflammation has burnt out and the gland is scarred and empty, the overall blood supply is markedly reduced. Examples of the two types of end stage disease are seen in Figure 16. scarred and empty, the overall blood supply is markedly reduced. Examples of the two types of end stage disease are seen in Figure 16.
(A) (B) Figure 16. Thyroid ultrasound findings in 2 patients with different features of late-stage Hashimoto thyroiditis. In (A) the dominant feature is diffuse hypo echoicity, seen as black "holes" indicating the absence of thyroid tissue, some scarring, decreased vascularity and architectural damage in an overall enlarged gland. In (B), the thyroid gland is now shrunken, scarred and shrivelled with pseudo nodules and scattered fibrous bands in a small gland; this is the final stage and the patient has no thyroid function.

Transient Thyroiditis
The sonographic appearance of the various forms of transient thyroiditis, namely subacute thyroiditis, silent thyroiditis and post-partum thyroiditis, is worthy of mention as this has not been described in detail by others. Taking subacute thyroiditis as a model for the changes that occur during inflammation and on recovery, we see that the gland appears very abnormal when the patient is hyperthyroid with hypoechoic "streaks" infiltrating the gland, as seen in Figure 17. On recovery, the gland returns to normal as the thyroid follicular cells recover. Even though the tissue damage in subacute thyroiditis reflects virus infection, or a post viral reaction, and that in the latter two disorders, an immunological process, the ultrasound changes seen in all three disorders are similar. Figure 17. Thyroid ultrasound from a patient with sub-acute thyroiditis. The impressive looking black streaks seen in the acute phase rapidly disappear as the gland recovers and the texture returns to normal.

Parathyroid Disease
Because the senior author (JW) routinely measures serum calcium, parathyroid hormone (PTH) and vitamin D in his patients, hyperparathyroidism due to a benign Figure 16. Thyroid ultrasound findings in 2 patients with different features of late-stage Hashimoto thyroiditis. In (A) the dominant feature is diffuse hypo echoicity, seen as black "holes" indicating the absence of thyroid tissue, some scarring, decreased vascularity and architectural damage in an overall enlarged gland. In (B), the thyroid gland is now shrunken, scarred and shrivelled with pseudo nodules and scattered fibrous bands in a small gland; this is the final stage and the patient has no thyroid function.

Transient Thyroiditis
The sonographic appearance of the various forms of transient thyroiditis, namely subacute thyroiditis, silent thyroiditis and post-partum thyroiditis, is worthy of mention as this has not been described in detail by others. Taking subacute thyroiditis as a model for the changes that occur during inflammation and on recovery, we see that the gland appears very abnormal when the patient is hyperthyroid with hypoechoic "streaks" infiltrating the gland, as seen in Figure 17. On recovery, the gland returns to normal as the thyroid follicular cells recover. Even though the tissue damage in subacute thyroiditis reflects virus infection, or a post viral reaction, and that in the latter two disorders, an immunological process, the ultrasound changes seen in all three disorders are similar. scarred and empty, the overall blood supply is markedly reduced. Examples of the two types of end stage disease are seen in Figure 16.
(A) (B) Figure 16. Thyroid ultrasound findings in 2 patients with different features of late-stage Hashimoto thyroiditis. In (A) the dominant feature is diffuse hypo echoicity, seen as black "holes" indicating the absence of thyroid tissue, some scarring, decreased vascularity and architectural damage in an overall enlarged gland. In (B), the thyroid gland is now shrunken, scarred and shrivelled with pseudo nodules and scattered fibrous bands in a small gland; this is the final stage and the patient has no thyroid function.

Transient Thyroiditis
The sonographic appearance of the various forms of transient thyroiditis, namely subacute thyroiditis, silent thyroiditis and post-partum thyroiditis, is worthy of mention as this has not been described in detail by others. Taking subacute thyroiditis as a model for the changes that occur during inflammation and on recovery, we see that the gland appears very abnormal when the patient is hyperthyroid with hypoechoic "streaks" infiltrating the gland, as seen in Figure 17. On recovery, the gland returns to normal as the thyroid follicular cells recover. Even though the tissue damage in subacute thyroiditis reflects virus infection, or a post viral reaction, and that in the latter two disorders, an immunological process, the ultrasound changes seen in all three disorders are similar. Figure 17. Thyroid ultrasound from a patient with sub-acute thyroiditis. The impressive looking black streaks seen in the acute phase rapidly disappear as the gland recovers and the texture returns to normal.

Parathyroid Disease
Because the senior author (JW) routinely measures serum calcium, parathyroid hormone (PTH) and vitamin D in his patients, hyperparathyroidism due to a benign Figure 17. Thyroid ultrasound from a patient with sub-acute thyroiditis. The impressive looking black streaks seen in the acute phase rapidly disappear as the gland recovers and the texture returns to normal.

Parathyroid Disease
Because the senior author (JW) routinely measures serum calcium, parathyroid hormone (PTH) and vitamin D in his patients, hyperparathyroidism due to a benign adenoma of one of the parathyroid glands appears to be much more common than previously thought. The parathyroid glands are hidden behind the thyroid and so may be obscured by thyroid nodules, although they can often be seen in the longitudinal view below the lobes, as a hypoechoic lesion of around 1 cm in diameter (Figure 18). adenoma of one of the parathyroid glands appears to be much more common than previously thought. The parathyroid glands are hidden behind the thyroid and so may be obscured by thyroid nodules, although they can often be seen in the longitudinal view below the lobes, as a hypoechoic lesion of around 1 cm in diameter ( Figure 18). The parathyroid adenoma is typically hypoechoic by comparison to the nearby thyroid tissue, which is consistent with the author's experience. However, only about 50% of subsequently proven parathyroid adenomas are seen on ultrasound and even the Sestamibi nuclear scan fails to pick them up in about 30% of cases. Figure 18. Thyroid ultrasound from a patient with hyperparathyroidism showing a hypoechoic lesion below the right thyroid lobe that was confirmed to be a parathyroid adenoma at surgery.

Does the Thyroid Specialist have Advantages over the Consultant Radiologist?
The consultant radiologist does not always report on those features of thyroid lesions that are essential to interpreting the clinical and other findings. For example, in the senior author's (JW) experience, the diffuse familial fibrotic variant of papillary thyroid cancer has been described as "localised Hashimoto thyroiditis", which does not exist, and the inflammatory lesions of Hashimoto thyroiditis and Graves' hyperthyroidism are often referred to as "nodules" and are counted and measured. Recommending biopsy of a thyroid nodule based on its size only-rather than the presence or not of suspicious features-is problematic, since it wrongly assumes that small nodules are never cancerous.
More recently, the emphasis has shifted to classifying nodules according to their degree of suspicion for cancer, regardless of their size. In the context of this changing approach to assessing thyroid nodules, a new scoring system, known as TI-RADS [15,16], has been developed to allow everyone who carries out thyroid ultrasonography, whether technician, radiologist or endocrinologist, to be consistent in how they characterise and report features of thyroid nodules. As a result of the now almost universal use of TI-RADS, the tendency is to carry out more ultrasounds and fewer biopsies. This seems logical because we should remember that only about 5% of patients with one or more thyroid nodules turn out to have thyroid cancer. Finally, in respect to who is best qualified to carry out thyroid ultrasonography, we recommend that the role of clinician practiced ultrasound in either confirming of changing ultrasound/radiology findings of patients presenting with imaging performed before referral be addressed in a prospective study. Figure 18. Thyroid ultrasound from a patient with hyperparathyroidism showing a hypoechoic lesion below the right thyroid lobe that was confirmed to be a parathyroid adenoma at surgery.
The parathyroid adenoma is typically hypoechoic by comparison to the nearby thyroid tissue, which is consistent with the author's experience. However, only about 50% of subsequently proven parathyroid adenomas are seen on ultrasound and even the Sestamibi nuclear scan fails to pick them up in about 30% of cases.

Does the Thyroid Specialist have Advantages over the Consultant Radiologist?
The consultant radiologist does not always report on those features of thyroid lesions that are essential to interpreting the clinical and other findings. For example, in the senior author's (JW) experience, the diffuse familial fibrotic variant of papillary thyroid cancer has been described as "localised Hashimoto thyroiditis", which does not exist, and the inflammatory lesions of Hashimoto thyroiditis and Graves' hyperthyroidism are often referred to as "nodules" and are counted and measured. Recommending biopsy of a thyroid nodule based on its size only-rather than the presence or not of suspicious features-is problematic, since it wrongly assumes that small nodules are never cancerous.
More recently, the emphasis has shifted to classifying nodules according to their degree of suspicion for cancer, regardless of their size. In the context of this changing approach to assessing thyroid nodules, a new scoring system, known as TI-RADS [15,16], has been developed to allow everyone who carries out thyroid ultrasonography, whether technician, radiologist or endocrinologist, to be consistent in how they characterise and report features of thyroid nodules. As a result of the now almost universal use of TI-RADS, the tendency is to carry out more ultrasounds and fewer biopsies. This seems logical because we should remember that only about 5% of patients with one or more thyroid nodules turn out to have thyroid cancer. Finally, in respect to who is best qualified to carry out thyroid ultrasonography, we recommend that the role of clinician practiced ultrasound in either confirming of changing ultrasound/radiology findings of patients presenting with imaging performed before referral be addressed in a prospective study.

Vocal Cord Assessment
Recently, the thyroid specialist has found a new use for their portable ultrasound machine. Although thyroid surgeons generally send their patients to an ENT specialist for direct laryngoscopic assessment of the vocal cords to identify any problem that was present before surgery, the thyroid specialist can learn to recognize and quantify normal abduction and adduction of the true vocal cord, especially in female patients. They do this by placing the small parts probe in a transverse plane across the anterior wall of the larynx just below the thyroid notch, with the patient speaking or humming (preferably in tune).

The Future
New approaches to the use of ultrasound to assess thyroid nodules including shear wave elastography, which measures tissue stiffness, are being developed in order to help identify those nodules that need to be biopsied. Thyroid specialists in Europe often treat thyroid cysts by injecting 90% alcohol to replace the fluid removed, and some solid nodules are treated by laser ablation. These procedures are rarely used in North America and Australia, countries where the senior author (JW) has worked, and it is unlikely that this approach will ever become mainstream outside of Europe. Institutional Review Board Statement: This review includes deidentified anonymous ultrasound images from Dr Wall's private practice. Ethics review is not needed for this review. No new data are included in the review which is therefore not a "study" (but a review) We refer to the ultrasound staging system and include the reference for this published paper.

Informed Consent Statement: Not applicable.
Data Availability Statement: Not applicable.