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Clinical and Translational Neuroscience is published by MDPI from Volume 5 Issue 2 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with SAGE.
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Article

Factors Associated with Abnormal Cerebral Blood Flow in Egyptian Children with Sickle Cell Disease

by
Foad Abd-Allah
1,*,
Mona Eltagui
2,
Alshaimaa Mahmoud Aboulfotooh
1,
Nirmeen Adel Kishk
1,
Mohammad Ahmed Farrag
1,
Sandra Ahmed Mohammed
1,
Reham Mohammed Shamloul
1,
Shaimaa El-Jaafary
1,
Fadwa Said
3,
Ahmed Ibrahim
4 and
Mona Elghamrawy
2
1
Neurovascular Unit, Department of Neurology, Cairo University, Giza 12613, Egypt
2
Pediatric Hematology and BMT Unit, Department of Pediatrics, Cairo University, Giza 12613, Egypt
3
Department of Clinical and Chemical Pathology, Cairo University, Giza 12613, Egypt
4
Department of Pediatrics, Jaber Al Ahmed Hospital, Hawally, Kuwait
*
Author to whom correspondence should be addressed.
Clin. Transl. Neurosci. 2020, 4(1), 6; https://doi.org/10.1177/2514183x20911351
Submission received: 27 September 2019 / Accepted: 8 February 2020 / Published: 16 March 2020
Versions Notes

Abstract

Background: Transcranial Doppler (TCD) is a well-established tool for cerebrovascular assessment. Estimating the flow velocity across the intracranial arteries helps to identify children with sickle cell anaemia who are at risk for stroke. Objective: Our aim is to correlate TCD findings with clinical condition in children with sickle cell disease (SCD) to determine the value of TCD assessment as a predictive tool for stroke in SCD and to identify any association of TCD findings with disease severity, transfusion therapy and treatment administered. Methods: Eighty-five paediatric SCD patients aged from 3 years to 18 years of both genders who were followed up at the Hematology Clinic of New Children’s Hospital at Cairo University were included in this cross-sectional observational study. All our participants underwent routine laboratory investigations and TCD assessments. Results: Oof the 85 patients, two patients (2.3%) died before completing the TCD study and eventually 83 patients were included in the analysis. Seventeen (20.5%) patients had abnormal TCD findings, seven (8.4%) patients showed high-risk findings and 10 (12.1%) patients had conditional flow pattern. Logistic linear regression analysis confirmed that annual frequency of blood transfusion and hydroxyurea (HU) dose were associated with a decreased risk of abnormal TCD findings. Conclusion: The current study demonstrates that our TCD data reproduce the findings of other studies and that it is very likely the results from large trials are applicable for Egyptian children. The annual frequency of blood transfusion and HU dose were associated with a decreased frequency of abnormal TCD findings.
Keywords: transcranial Doppler; abnormal blood flow; stroke; sickle cell disease transcranial Doppler; abnormal blood flow; stroke; sickle cell disease

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MDPI and ACS Style

Abd-Allah, F.; Eltagui, M.; Aboulfotooh, A.M.; Kishk, N.A.; Farrag, M.A.; Mohammed, S.A.; Shamloul, R.M.; El-Jaafary, S.; Said, F.; Ibrahim, A.; et al. Factors Associated with Abnormal Cerebral Blood Flow in Egyptian Children with Sickle Cell Disease. Clin. Transl. Neurosci. 2020, 4, 6. https://doi.org/10.1177/2514183x20911351

AMA Style

Abd-Allah F, Eltagui M, Aboulfotooh AM, Kishk NA, Farrag MA, Mohammed SA, Shamloul RM, El-Jaafary S, Said F, Ibrahim A, et al. Factors Associated with Abnormal Cerebral Blood Flow in Egyptian Children with Sickle Cell Disease. Clinical and Translational Neuroscience. 2020; 4(1):6. https://doi.org/10.1177/2514183x20911351

Chicago/Turabian Style

Abd-Allah, Foad, Mona Eltagui, Alshaimaa Mahmoud Aboulfotooh, Nirmeen Adel Kishk, Mohammad Ahmed Farrag, Sandra Ahmed Mohammed, Reham Mohammed Shamloul, Shaimaa El-Jaafary, Fadwa Said, Ahmed Ibrahim, and et al. 2020. "Factors Associated with Abnormal Cerebral Blood Flow in Egyptian Children with Sickle Cell Disease" Clinical and Translational Neuroscience 4, no. 1: 6. https://doi.org/10.1177/2514183x20911351

APA Style

Abd-Allah, F., Eltagui, M., Aboulfotooh, A. M., Kishk, N. A., Farrag, M. A., Mohammed, S. A., Shamloul, R. M., El-Jaafary, S., Said, F., Ibrahim, A., & Elghamrawy, M. (2020). Factors Associated with Abnormal Cerebral Blood Flow in Egyptian Children with Sickle Cell Disease. Clinical and Translational Neuroscience, 4(1), 6. https://doi.org/10.1177/2514183x20911351

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