Epidemiologic, Imaging, and Clinical Issues in Bezold’s Abscess: A Systematic Review

Bezold’s abscess is a deep neck abscess related to otomastoiditis. Due to the insidious clinical presentation, diagnosis can be extremely challenging, leading to delays in treatment and possible life-threatening complications. The literature currently provides a fragmented picture, presenting only single or small number of cases. The present study aims at examining our experience and the literature findings (based on PRISMA criteria) of 97 patients with Bezold’s abscess, summarizing their epidemiology, pathogenesis, clinical presentation, imaging findings, and treatments. Bezold’s abscess is found at any age, with overt male prevalence among adults. The clinical presentation, as well as the causative pathogens, are strikingly heterogeneous. Otomastoiditis and cholesteatoma are major risk factors. A clinical history of otitis is commonly reported (43%). CT and MRI are the main diagnostic tools, proving the erosion of the mastoid tip in 53% of patients and the presence of a concomitant cholesteatoma in 40%. Intracranial vascular (24%) or infectious (9%) complications have also been reported. Diagnosis might be easily achieved when imaging (CT) is properly applied. MRI has a limited diagnostic role, but it might be crucial whenever intracranial complications or the coexistence of cholesteatoma are suspected, helping to develop proper treatment (prompt antibiotic therapy and surgery).


Introduction
Bezold's abscess is a potentially life-threatening laterocervical/deep neck abscess complicating the course of an otomastoiditis [1,2]. First described in 1885 by Friedrich von Bezold [3], Bezold's abscess is the spread of an aggressive middle ear and mastoid infectious process, through an erosion at the digastric ridge, deep in the neck between the digastric and sternocleidomastoid muscles ( Figure 1).
Despite the high incidence of acute otitis media, Bezold's abscesses are rare, especially in the pediatric population [4]. In a recent study considering around 5 million visits for acute otitis media, no patient presented such a complication [5]. However, Bezold's abscesses are often underreported: over the last 20 years, at least four cases have been observed in the Neuroradiology Unit of Padova University Hospital. In addition, because of the high risk for life-threatening intracranial, neck, or even mediastinal complications [6], Bezold's abscess requires early diagnosis, treatment, and surgery [7]. As the existing knowledge is based on single cases or small series of cases, providing a fragmented and heterogeneous picture of Bezold's abscess, we have reviewed the existing literature In the same images with annotations (c,d), the digastric muscle (white arrowhead) and the sternocleidomastoid muscle (white arrow) delimitate the posterior cervical space (red). The carotid artery can be identified nearby (black arrow).
Despite the high incidence of acute otitis media, Bezold's abscesses are rare, especially in the pediatric population [4]. In a recent study considering around 5 million visits for acute otitis media, no patient presented such a complication [5]. However, Bezold's abscesses are often underreported: over the last 20 years, at least four cases have been observed in the Neuroradiology Unit of Padova University Hospital. In addition, because of the high risk for life-threatening intracranial, neck, or even mediastinal complications [6], Bezold's abscess requires early diagnosis, treatment, and surgery [7]. As the existing knowledge is based on single cases or small series of cases, providing a fragmented and heterogeneous picture of Bezold's abscess, we have reviewed the existing literature focusing on epidemiology, pathogenesis, clinical presentation, imaging tools and features, differential diagnosis, and treatments.

Materials and Methods
The PubMed database and Google Scholar were screened up to August 2021, using the following Keywords and Meshes: "Bezold's abscess"; "Bezold" AND "abscess"; "Bezold's mastoiditis". The literature search was performed by two authors independently (SV and MM), according to PRISMA criteria ( Figure 2). In the same images with annotations (c,d), the digastric muscle (white arrowhead) and the sternocleidomastoid muscle (white arrow) delimitate the posterior cervical space (red). The carotid artery can be identified nearby (black arrow).

Materials and Methods
The PubMed database and Google Scholar were screened up to August 2021, using the following Keywords and Meshes: "Bezold's abscess"; "Bezold" AND "abscess"; "Bezold's mastoiditis". The literature search was performed by two authors independently (SV and MM), according to PRISMA criteria ( Figure 2).
All the retrieved publications were evaluated to identify the most relevant articles. Duplications or aggregations of pre-existing data were excluded; only articles in English and Spanish were included. The reference lists of selected articles were also analyzed to identify additional studies.
Every misalignment the authors had with regards to article eligibility was solved through discussion.
Eighty-eight articles were identified: four were excluded due to unavailability of their full text both online and in main Italian medical libraries. Eighty-four studies were therefore considered; publication year ranged between 1898 and 2021.Our direct experience of four cases (three of them already published) were also considered for discussion and for imaging illustration. The chi-square test and Student's t-test were used when appropriate; a p < 0.05 was considered significant. All the retrieved publications were evaluated to identify the most relevant articles. Duplications or aggregations of pre-existing data were excluded; only articles in English and Spanish were included. The reference lists of selected articles were also analyzed to identify additional studies.
Every misalignment the authors had with regards to article eligibility was solved through discussion.
Eighty-eight articles were identified: four were excluded due to unavailability of their full text both online and in main Italian medical libraries. Eighty-four studies were therefore considered; publication year ranged between 1898 and 2021.Our direct experience of four cases (three of them already published) were also considered for discussion and for imaging illustration.
The chi-square test and Student's t-test were used when appropriate; a p < 0.05 was considered significant.
There was no significant difference in age between males and females (p = 0.4), whereas sex distribution differed significantly between pediatric and adult patients (p = 0.01). Bezold's abscess occurred similarly in males and females who were up to 5 years old (four male vs. three female patients; male-to-female ratio = 1.33) and under 18 years old (13 male vs. 10 female patients; male-to-female ratio = 1.30). In contrast, among adult and elderly patients, males were strikingly more frequently affected (61 male vs. 13 female patients: male-to-female ratio = 4.69).
There was no significant difference in age between males and females (p = 0.4), whereas sex distribution differed significantly between pediatric and adult patients (p = 0.01). Bezold's abscess occurred similarly in males and females who were up to 5 years old (four male vs. three female patients; male-to-female ratio = 1.33) and under 18 years old (13 male vs. 10 female patients; male-to-female ratio = 1.30). In contrast, among adult and elderly patients, males were strikingly more frequently affected (61 male vs. 13 female patients: male-to-female ratio = 4.69).

Epidemiology
Bezold's abscess is rare but can be found at any age. Its occurrence in the first five years of life has been considered anecdotal, due to the lack of pneumatization of the mastoid cells and the consequently thicker mastoid walls [8] that hamper the spread of the infection through this path. However, children under five represent nearly 7% of reported patients; this could be explained by a mere publication bias due to the well-known rarity and atypical presentation in the first years of life or by higher frequency of mastoiditis in children.
Furthermore, sex differences in mastoid development and pneumatization [9,10] might likely favor the spread of suppurative processes in adult males, among whom the frequency of Bezold's abscess is higher.

Pathogenesis
Bezold's abscess typically complicates the course of chronic/recurrent otomastoiditis, even though few exceptions have been reported (acute otomastoiditis, external otitis, os tympanicum cholesteatoma). This specific type of abscess accounts for 6% of otogenic abscesses [11]. Indeed, otitis media commonly spreads to the mastoid. Subsequent inflammatory hypertrophy of the mucosa of aditus ad antrum might block the suppurative process into the mastoid cells, giving origin to coalescent mastoiditis [12].
According to the currently leading hypothesis, the retained purulent collection can lead to erosion of the cortical bone in a locus minoris resistentiae, the digastric groove, forcing the drainage of the pus into the neck (Bezold's abscess) [3]. This hypothesis is supported by the common detection of cholesteatomas in Bezold's abscess (40%).
Cholesteatomas are slowly growing masses usually appearing in the middle ear, occupying the Prussak space, expanding upwards and displacing the ossicles [13]. When a middle ear infection occurs, its growth pattern might block the path towards the external acoustic meatus [14] facilitating Bezold's abscess formation. Notably, cholesteatoma may worsen the ventilation of the ear cavities promoting recurrent superinfections. In addition, bone erosion might be facilitated and is more conspicuous in the presence of cholesteatoma.
Among the 39 patients with cholesteatoma, only one showed an intact mastoid, as the lesion stemmed from the os tympanicum [15]. In some cases, the cholesteatoma might drop into the neck through Bezold's abscess pathway [16,17]. Furthermore, around 28% (11/39) of patients with Bezold's and cholesteatoma had a previous history of oto-mastoid surgery. In these patients, the risk of Bezold's abscess might be further increased by the presence of post-surgery bone alterations, ref. [8] thus justifying the use of follow-up MRI to promptly detect cholesteatomatous residuals or recurrences (see Section 4.7).
Microbiological cultures' results were strikingly heterogeneous in the reviewed cases, possibly also because early empirical antibiotics therapy might hamper pathogen identification. The large spectrum of pathogens emerging from the analysis of existing literature has obvious implications for diagnosis and treatment.

Clinical Presentation
Bezold's abscess might be difficult to recognize, as its clinical presentation is highly heterogeneous, ranging from signs of neck tissue inflammation or fever to otorrhea or facial paralysis. Neck symptoms are the most reported (Table 2), even though publication bias cannot be excluded.
The evaluation through palpation is limited, as the purulent collection lies deep in the neck [7,8], where muscular and fascial planes constitute an anatomic barrier to the spread of the pus towards the surface.
Laboratory parameters are usually altered, with elevated leukocytes and C-reactive protein or erythrocyte sedimentation rate, consistently with a bacterial infection. In rare cases (four patients in literature) laboratory tests may be unremarkable or slightly above normality. In these cases, tuberculous otitis media [25,40], poorly controlled HIV [41], and cholesteatoma [42] were the underlying diseases and fever was absent [41,42] or not reported [25,40].

Differential Diagnosis
Differential diagnosis mainly includes lymphadenopathies, infected branchial cysts, temporal bone subperiosteal empyema, and other neck abscesses. The differential diagnoses are derived from available case reports investigating the main reasons for Bezold's abscess diagnostic delay.
Bezold's abscess might mimic a lymphadenopathy accompanying otitis [43]. Neck ultrasonography might help with recognizing reactive lymph nodes or identifying hypo/ anechoic collections [44]. Infected branchial cysts might have a clinical and radiological presentation similar to Bezold's abscess, but the mastoid is not involved, and bone erosion is never observed.
When dealing with suppurative processes originating from the mastoid bone, the diffusion pathway through the neck should be considered as this might be pivotal for subsequent evolution and for treatment planning. Suppurative processes from the mastoid might spread through bone erosion along three different paths: medial, lateral, or posteromedial [45]. Due to the complex anatomy of the several neck muscles and fasciae connected to the mastoid, the site of bone erosion will determine the subsequent diffusion path of the suppurative process that is eventually classified with different eponyms (Figure 3). A bone erosion medial to the mastoid allows the pus to spread to the posterior cervical and perivertebral spaces, deep into the sternocleidomastoid muscle (Bezold's abscess); a posteromedial bone erosion can result in pus spreading posteriorly to the insertion of the digastric muscle and in the occipital region (Citelli's abscess); a bone erosion lateral to the mastoid can give origin to a subperiosteal empyema that usually reaches the surface in the peri-mastoid subcutaneous spaces. However, this strict classification might not be appropriate in case of neck anatomy variants, erroneous identification of suppurative diffusion processes or coexistence of multiple paths. In fact, literature reports cases of Bezold's abscess concomitant to subperiosteal empyema [22,30,38,[46][47][48][49], occurring after mastoid surgery (i.e., consistent with a postoperative complication [24]) or spreading into the occipital region [50,51]. A spread to retro-parapharyngeal spaces has also been described in literature [8,32,34,42,52].

Imaging Features
Ultrasonography can represent a valuable first-line diagnostic tool, especially with children, to exclude reactive lymph nodes and detect neck abscesses that appear as ane- A bone erosion medial to the mastoid allows the pus to spread to the posterior cervical and perivertebral spaces, deep into the sternocleidomastoid muscle (Bezold's abscess); a posteromedial bone erosion can result in pus spreading posteriorly to the insertion of the digastric muscle and in the occipital region (Citelli's abscess); a bone erosion lateral to the mastoid can give origin to a subperiosteal empyema that usually reaches the surface in the peri-mastoid subcutaneous spaces. However, this strict classification might not be appropriate in case of neck anatomy variants, erroneous identification of suppurative diffusion processes or coexistence of multiple paths. In fact, literature reports cases of Bezold's abscess concomitant to subperiosteal empyema [22,30,38,[46][47][48][49], occurring after mastoid surgery (i.e., consistent with a postoperative complication [24]) or spreading into the occipital region [50,51]. A spread to retro-parapharyngeal spaces has also been described in literature [8,32,34,42,52].

Imaging Features
Ultrasonography can represent a valuable first-line diagnostic tool, especially with children, to exclude reactive lymph nodes and detect neck abscesses that appear as anechoic or hypoechoic inhomogeneous collections [44].
However, CT and MRI are the best tools in identifying abscesses and concomitant mastoiditis features and providing useful information for the surgical approach as simple neck abscess drainage might be insufficient for eradicating the infection and ultrasonography shows only the "tip of the iceberg" and not the source of infection [8]. In addition, a precise differentiation between Bezold's abscess and other neck abscesses of otogenic origin might help the surgeon with localizing the bone defect while evaluating the mastoid [45].

CT
In the clinical suspicion of a Bezold's abscess, temporal bone CT and contrast enhanced neck CT are the gold standard [7] for defining two main diagnostic aspects: (1) the site of mastoid bone erosion in the context of a mastoiditis and (2) the anatomical boundaries of the neck suppurative collection. Temporal bone CT typically shows signs of mastoiditis, such as opacification of the mastoid cells and erosion of the mastoid bone trabeculae. High resolution (slice thickness < 1 mm), coronal plane reconstructions, high frequency bone kernel and bone window are suggested to enable the detection of small bone interruptions at the mastoid tip, generally at the digastric groove ( Figure 4).

CT
In the clinical suspicion of a Bezold's abscess, temporal bone CT and contrast enhanced neck CT are the gold standard [7] for defining two main diagnostic aspects: (1) the site of mastoid bone erosion in the context of a mastoiditis and (2) the anatomical boundaries of the neck suppurative collection. Temporal bone CT typically shows signs of mastoiditis, such as opacification of the mastoid cells and erosion of the mastoid bone trabeculae. High resolution (slice thickness < 1 mm), coronal plane reconstructions, high frequency bone kernel and bone window are suggested to enable the detection of small bone interruptions at the mastoid tip, generally at the digastric groove (Figure 4).  However, despite its crucial pathogenic role for the suppurative path, bone defects in the mastoid tip have been precisely outlined only in around half of all literature reports (51/97 patients, 53%;). Indeed, in 7/97 patients (7%) the mastoid tip was considered intact, revealing that the diagnosis of Bezold's abscess can be achieved even without overt bone erosion, especially in younger children (3/7 patients were younger than 5 years old). The However, despite its crucial pathogenic role for the suppurative path, bone defects in the mastoid tip have been precisely outlined only in around half of all literature reports (51/97 patients, 53%). Indeed, in 7/97 patients (7%) the mastoid tip was considered intact, revealing that the diagnosis of Bezold's abscess can be achieved even without overt bone erosion, especially in younger children (3/7 patients were younger than 5 years old). The incomplete pneumatization of mastoid cells before the age of five is well known and is supposed to hinder the diffusion of the suppurative process across the thickened mastoid bone wall. Before the age of five, more destructive infectious processes or emissary vein bone canals likely allow Bezold's abscess occurrence [8]. A recent case of a woman affected by Goldenhar syndrome with an unremarkable mastoid bone ( Figure 5) highlighted those atypical origins of Bezold's abscess that should be accurately investigated in syndromic patients [15]. Temporal bone CT also allows for detection of intracranial bone erosions possibly leading to further life-threatening complications [8]: sinus thrombosis, posterior cranial fossa abscess/empyema, or meningitis/meningoencephalitis have been reported in 25/97 patients.
Contrast-enhanced neck CT aims at demonstrating and precisely defining the anatomical limits of the neck abscess that appears as a low-attenuation collection with typical rim enhancement ( Figure 4) and surrounding soft tissue oedema. Neck CT should be reconstructed with 2-3 mm thick slices and a soft tissue kernel and window. The suppurative collection is usually located under the sternocleidomastoid muscle, in the posteriorcervical or perivertebral spaces, but extensions into the retropharyngeal space [30,51], parapharyngeal space [30,42,45,53], or even into the thorax [24,26,46,54] have been described, coherently with neck fascial anatomy and least resistance pathways.
In some patients the abscess might trespass the deep cervical fascia and reach the Temporal bone CT also allows for detection of intracranial bone erosions possibly leading to further life-threatening complications [8]: sinus thrombosis, posterior cranial fossa abscess/empyema, or meningitis/meningoencephalitis have been reported in 25/97 patients.
Contrast-enhanced neck CT aims at demonstrating and precisely defining the anatomical limits of the neck abscess that appears as a low-attenuation collection with typical rim enhancement ( Figure 4) and surrounding soft tissue oedema. Neck CT should be reconstructed with 2-3 mm thick slices and a soft tissue kernel and window. The suppurative collection is usually located under the sternocleidomastoid muscle, in the posterior-cervical or perivertebral spaces, but extensions into the retropharyngeal space [30,51], parapharyngeal space [30,42,45,53], or even into the thorax [24,26,46,54] have been described, coherently with neck fascial anatomy and least resistance pathways.
In some patients the abscess might trespass the deep cervical fascia and reach the surface (see Section 4.3) subverting neck anatomy and escaping the classic path of Bezold's abscess diffusion. For this reason, even the precise characterization of mastoid tip bone destruction might not accurately predict the path of infection. Contrast-enhanced CT might be extended to the brain if neurological conditions are rapidly deteriorating; CT angiography can be applied to rapidly diagnose dural sinus thrombosis. However, MRI should be preferred whenever intracranial complications are suspected [8].

MRI
The role of MRI in the diagnosis of Bezold's abscess is generally limited, being a "problem solving modality" used when intracranial complications or osseous disease are expected. In literature, MRI findings are reported for only 21/97 patients. Indeed, the first MRI report dates to 2001. The low rate of MRI reports likely depends on two concomitant factors: MRI was not available at diagnosis and CT was considered sufficient for proper surgical planning and patient management. However, MRI might be better in specific clinical circumstances (for example, when intracranial complications are present, a cholesteatoma is suspected, the purulent content of intracranial or neck collections should be proven) as diffusion-weighted imaging (DWI) best differentiates non-infectious fluid collections from bacterial abscesses.
Bezold's abscess entails a moderate risk of intracranial vascular (23/97) or further infectious (9/97) complications. MRI protocols should therefore include DWI and vascular imaging. DWI best recognizes suppurative collections (abscess, empyema, or even intraventricular debris) showing hyperintense signal on DWI with usually decreased apparent diffusion coefficient values (i.e., restriction of water molecule diffusion). DWI also detects cytotoxic oedema and intravascular thrombi helping in recognizing recent ischemic strokes or sinus venous thrombosis. Artery and venous intracranial MR-angiography can detect vessel occlusion consistent with thrombosis, thus confirming CT-angiography findings and allowing a less invasive follow-up. These sole sequences cover most intracranial complications of mastoiditis associated with Bezold's abscess and are therefore of utmost importance for subsequent patient management.
In the literature, cholesteatoma ipsilateral to Bezold's abscess was reported in around 40% of patients. Cholesteatoma likely favors repeated mastoid bacterial superinfections and facilitates, by bone erosion, the spread of suppurative process into the neck (see Section 4.2). In several patients, cholesteatoma was diagnosed at surgery (11/97) and in a few cases it was partially an unexpected finding. However, MRI might easily recognize cholesteatoma preoperatively as these cysts appear as strikingly hyperintense DWI ovoid masses [42]. Differently from purulent collections, apparent diffusion coefficient (ADC) values might be slightly increased in cholesteatomas, suggesting a T2 shine-through effect more than a true water diffusion restriction [55]. From a technical point of view, whereas investigating the mastoid and the upper neck, non-echo-planar (non-EPI) DWI sequences should be preferred to minimize mastoid air/bone susceptibility artifacts that could mask the cholesteatoma [56]. DWI represents a very powerful tool also in postoperative and follow-up examinations, allowing for the detection of small cholesteatomatous residuals or recurrences (Figure 6), especially those with a diameter larger than 2-4 mm [57].
As far as neck evaluation, MRI usually shows a well-defined area of low T1 and high T2 signal with DWI restriction, a peripherally enhancing rim, and surrounding soft tissue oedema that raise up the mass effect. MRI is better than CT due to its better soft tissues contrast [58]: involved anatomical regions and planes of the neck might be easier to recognize. In coronal planes, communication between mastoid and neck collections through the mastoid tip can be seen [59], thus helping the diagnosis of Bezold's abscess. Notably, MRI does not use ionizing radiation and might be safer, especially when dealing with young/pediatric patients. MRI gadolinium-based contrast agents are also safer than CT iodine-based contrast agents in patients with impaired renal function (c) and in diabetic patients [60] and present less adverse effects. In the literature, MRI was performed in severe renal impairment (1/21) [61] or in patients of a young age (7/21 were pediatrics and additional 7/21 were younger than 35 years).
ogenesis" sub-section). In several patients, cholesteatoma was diagnosed at su (11/97) and in a few cases it was partially an unexpected finding. However, MRI easily recognize cholesteatoma preoperatively as these cysts appear as strikingly h intense DWI ovoid masses [42]. Differently from purulent collections, apparent diff coefficient (ADC) values might be slightly increased in cholesteatomas, suggesting shine-through effect more than a true water diffusion restriction [55]. From a tec point of view, whereas investigating the mastoid and the upper neck, non-echo-p (non-EPI) DWI sequences should be preferred to minimize mastoid air/bone suscept artifacts that could mask the cholesteatoma [56]. DWI represents a very powerful too in postoperative and follow-up examinations, allowing for the detection of small cho atomatous residuals or recurrences (Figure 6), especially those with a diameter large 2-4 mm [57]. As far as neck evaluation, MRI usually shows a well-defined area of low T1 and T2 signal with DWI restriction, a peripherally enhancing rim, and surrounding soft oedema that raise up the mass effect. MRI is better than CT due to its better soft t contrast [58]: involved anatomical regions and planes of the neck might be easier t ognize. In coronal planes, communication between mastoid and neck collections th the mastoid tip can be seen [59], thus helping the diagnosis of Bezold's abscess. No MRI does not use ionizing radiation and might be safer, especially when dealing young/pediatric patients. MRI gadolinium-based contrast agents are also safer th iodine-based contrast agents in patients with impaired renal function (c) and in di patients [60] and present less adverse effects. In the literature, MRI was performed vere renal impairment (1/21) [61] or in patients of a young age (7/21 were pediatric additional 7/21 were younger than 35 years).

Treatment
If Bezold's abscess is present or suspected, broad spectrum antibiotic therapy good cerebrospinal fluid penetration should be started, and appropriate imagin formed to evaluate location and size of the abscess collection. The routinely institute pirical broad-spectrum antibiotic therapy should cover most of the Gram-positiv Gram-negative aerobic and anaerobic pathogens, given the incidence of polymicrob fections (19/67 cases among patients with referred microbiological cultures). Early su is often mandatory to establish drainage of the middle ear (also through a myringo and mastoid cells. It is necessary to carry out a sampling of the purulent materia results of pathogen tests allow to replace as soon as possible the initially adminis broad-spectrum antibiotic with one to which the pathogen has (or the pathogens h known susceptibility [62,63]. If a deep neck fluid collection exists concurrently with alescent mastoiditis, a post-auricular incision is made, and a complete mastoide

Treatment
If Bezold's abscess is present or suspected, broad spectrum antibiotic therapy with good cerebrospinal fluid penetration should be started, and appropriate imaging performed to evaluate location and size of the abscess collection. The routinely instituted empirical broad-spectrum antibiotic therapy should cover most of the Gram-positive and Gramnegative aerobic and anaerobic pathogens, given the incidence of polymicrobial infections (19/67 cases among patients with referred microbiological cultures). Early surgery is often mandatory to establish drainage of the middle ear (also through a myringotomy) and mastoid cells. It is necessary to carry out a sampling of the purulent material. The results of pathogen tests allow to replace as soon as possible the initially administered, broadspectrum antibiotic with one to which the pathogen has (or the pathogens have) a known susceptibility [62,63]. If a deep neck fluid collection exists concurrently with a coalescent mastoiditis, a post-auricular incision is made, and a complete mastoidectomy should be performed in addition to the drainage of the deep neck abscess via a trans-cervical approach. After surgical drainage of the deep neck abscess collection, contrast-enhanced imaging control is recommended at 48-72 h, prior to removal of the suction drains.
These observations seem to be in line with a recent study that focused its attention on the management of Bezold's abscesses in a subgroup of cases of the last 20 years [64].

Conclusions
Bezold's abscess entails a high risk for life-threatening intracranial, neck, and chest complications. The knowledge of some clinical, anatomical, diagnostic, and treatment aspects derived from literature and this comprehensive case analysis can support clinicians in the most appropriate management, especially considering the imaging features that can save time for a prompt diagnosis and treatment.