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A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals

1
Preclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK
2
Department of Materials, Quantum Information Processing Interdisciplinary Research Collaboration, University of Oxford, Parks Road, Oxford OX1 3PH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Brian D. Ross
Tomography 2021, 7(1), 39-54; https://doi.org/10.3390/tomography7010004
Received: 29 January 2021 / Accepted: 1 February 2021 / Published: 7 February 2021
Standardisation of animal handling procedures for a wide range of preclinical imaging scanners will improve imaging performance and reproducibility of scientific data. Whilst there has been significant effort in defining how well scanners should operate and how in vivo experimentation should be practised, there is little detail on how to achieve optimal scanner performance with best practices in animal welfare. Here, we describe a system-agnostic, adaptable and extensible animal support cradle system for cardio-respiratory-synchronised, and other, multi-modal imaging of small animals. The animal support cradle can be adapted on a per application basis and features integrated tubing for anaesthetic and tracer delivery, an electrically driven rectal temperature maintenance system and respiratory and cardiac monitoring. Through a combination of careful material and device selection, we have described an approach that allows animals to be transferred whilst under general anaesthesia between any of the tomographic scanners we currently or have previously operated. The set-up is minimally invasive, cheap and easy to implement and for multi-modal, multi-vendor imaging of small animals. View Full-Text
Keywords: imaging-compatible; multi-modal imaging; multi-vendor; handling apparatus; optimisation imaging-compatible; multi-modal imaging; multi-vendor; handling apparatus; optimisation
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MDPI and ACS Style

Kersemans, V.; Gilchrist, S.; Allen, P.D.; Wallington, S.; Kinchesh, P.; Prentice, J.; Tweedie, M.; Warner, J.H.; Smart, S.C. A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals. Tomography 2021, 7, 39-54. https://doi.org/10.3390/tomography7010004

AMA Style

Kersemans V, Gilchrist S, Allen PD, Wallington S, Kinchesh P, Prentice J, Tweedie M, Warner JH, Smart SC. A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals. Tomography. 2021; 7(1):39-54. https://doi.org/10.3390/tomography7010004

Chicago/Turabian Style

Kersemans, Veerle; Gilchrist, Stuart; Allen, Philip D.; Wallington, Sheena; Kinchesh, Paul; Prentice, John; Tweedie, Martin; Warner, Jamie H.; Smart, Sean C. 2021. "A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals" Tomography 7, no. 1: 39-54. https://doi.org/10.3390/tomography7010004

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