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Non-Coding RNA, Volume 11, Issue 5
October 2025 - 10 articles
Cover Story: Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that do not encode proteins. Initially considered transcriptional noise, they are now recognized as key regulatory molecules in all forms of life, including fungi, where they can be very abundant. LncRNAs can originate from various genomic locations, either in intergenic regions or overlapping with protein-coding genes, often as antisense transcripts. They regulate gene expression through a wide variety of cis or trans mechanisms, including interference with the transcription of nearby genes, induction of epigenetic modifications, and interaction with target proteins. This article reviews the identification of lncRNAs in fungal transcriptomes and highlights the cases that have been most extensively studied. View this paper
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