Next Article in Journal
The Missing “lnc” between Genetics and Cardiac Disease
Previous Article in Journal
Identification of Genomic Loci Responsible for the Formation of Nuclear Domains Using Lampbrush Chromosomes
Open AccessFeature PaperCase Report

MicroRNAs as Appropriate Discriminators in Non-Specific Alpha-Fetoprotein (AFP) Elevation in Testicular Germ Cell Tumor Patients

1
Division of Oncology, Medical University of Graz, 8036 Graz, Austria
2
Department of Urology, Medical University of Graz, 8036 Graz, Austria
3
Division of Oncology and Research Unit for Non-Coding RNA and Genome Editing, Medical University of Graz, 8036 Graz, Austria
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2020, 6(1), 2; https://doi.org/10.3390/ncrna6010002
Received: 23 October 2019 / Revised: 9 December 2019 / Accepted: 28 December 2019 / Published: 1 January 2020
Testicular germ cell tumors (TGCTs) are the most commonly diagnosed malignancies in younger men. The monitoring of disease course and recurrence is supported by traditional tumor markers, including α-fetoprotein (AFP). AFP is physiologically synthesized in the liver and can be detected at increased levels in testicular cancer patients as well as under other benign liver diseases, which have been reported as a misleading cause of interpretation of TGCTs clinical course. A cluster of stem cell-associated microRNAs has been reported to outperform traditional tumor markers in newly diagnosed TGCTs, but the value of these microRNAs to differentiate between specific and unspecific AFP elevations, has never been reported. We report here a patient with chronic hepatitis B and normal liver related blood values presenting with a surgically removed primary TGCT and elevated AFP levels. Clinical staging revealed a suspect retroperitoneal metastatic lymph node together with other risk factors and first line treatment with PEB chemotherapy was administered. During curative treatment significantly rising AFP levels led to the assumption of chemo-resistant disease, mandating the initiation of salvage chemotherapy and surgical removal of the putative lymph node metastases. The AFP levels continuously decreased with the interruption of chemotherapeutic agents, indicating a chemotherapy-induced liver toxicity on the basis of pre-existing liver disease. MiR-371a-3p serum levels were not detectable in serum samples with elevated AFP levels. In conclusion, miR-371a-3p may be a reliable biomarker to differentiate between non-specific AFP elevations in TGCTs patients. View Full-Text
Keywords: testicular germ cell tumor; AFP; microRNA testicular germ cell tumor; AFP; microRNA
Show Figures

Figure 1

MDPI and ACS Style

Lembeck, A.L.; Puchas, P.; Hutterer, G.; Barth, D.A.; Terbuch, A.; Bauernhofer, T.; Pichler, M. MicroRNAs as Appropriate Discriminators in Non-Specific Alpha-Fetoprotein (AFP) Elevation in Testicular Germ Cell Tumor Patients. Non-Coding RNA 2020, 6, 2.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop