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Non-Coding RNA 2016, 2(2), 5;

Circulating microRNAs as Prognostic and Predictive Biomarkers in Patients with Colorectal Cancer

Department of Oncology, Herlev & Gentofte Hospital, DK-2730 Herlev, Denmark
Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Nørregade 10, DK-1165 Copenhagen, Denmark
Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), Via Vela 6, CH-6500 Bellinzona, Switzerland
Author to whom correspondence should be addressed.
Academic Editor: George Calin
Received: 14 October 2015 / Revised: 23 March 2016 / Accepted: 20 May 2016 / Published: 1 June 2016
Full-Text   |   PDF [194 KB, uploaded 1 June 2016]


MiRNAs are suggested as promising cancer biomarkers. They are stable and extractable from a variety of clinical tissue specimens (fresh frozen or formalin fixed paraffin embedded tissue) and a variety of body fluids (e.g., blood, urine, saliva). However, there are several challenges that need to be solved, considering their potential as biomarkers in cancer, such as lack of consistency between biomarker panels in independent studies due to lack of standardized sample handling and processing, use of inconsistent normalization approaches, and differences in patients populations. Focusing on colorectal cancer (CRC), divergent results regarding circulating miRNAs as prognostic or predictive biomarkers are reported in the literature. In the present review, we summarize the current data on circulating miRNAs as prognostic/predictive biomarkers in patients with localized and metastatic CRC (mCRC). View Full-Text
Keywords: circulating microRNA; colorectal cancer; prognostic; predictive; review circulating microRNA; colorectal cancer; prognostic; predictive; review
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Schou, J.V.; Johansen, J.S.; Nielsen, D.; Rossi, S. Circulating microRNAs as Prognostic and Predictive Biomarkers in Patients with Colorectal Cancer. Non-Coding RNA 2016, 2, 5.

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