Next Article in Journal
Restoring Waning Production of Volatile Organic Compounds in the Endophytic Fungus Hypoxylon sp. (BS15)
Next Article in Special Issue
Special Issue: Candida and Candidiasis
Previous Article in Journal
Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins
Previous Article in Special Issue
PS, It’s Complicated: The Roles of Phosphatidylserine and Phosphatidylethanolamine in the Pathogenesis of Candida albicans and Other Microbial Pathogens
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
J. Fungi 2018, 4(2), 68; https://doi.org/10.3390/jof4020068

Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis

Department of Plant Pathology and Microbiology, National Taiwan University, 10617 Taipei, Taiwan
*
Author to whom correspondence should be addressed.
Received: 27 April 2018 / Revised: 28 May 2018 / Accepted: 7 June 2018 / Published: 8 June 2018
(This article belongs to the Special Issue Candida and Candidiasis)
Full-Text   |   PDF [575 KB, uploaded 8 June 2018]   |  

Abstract

Fungal species undergo many morphological transitions to adapt to changing environments, an important quality especially in fungal pathogens. For decades, Candida albicans has been one of the most prevalent human fungal pathogens, and recently, the prevalence of Candida tropicalis as a causative agent of candidiasis has increased. In C. albicans, the ability to switch between yeast and hyphal forms is thought to be a key virulence factor and is regulated by multiple signaling cascades—including the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), calcineurin, high-osmolarity glycerol (HOG), and mitogen-activated protein kinases (MAPK) signaling pathways—upon receiving environmental cues. The cAMP/PKA signaling pathway also triggers white-opaque switching in C. albicans. However, studies on C. tropicalis morphogenesis are limited. In this minireview, we discuss the regulation of the yeast-hypha transition, virulence, and white-opaque switching through the cAMP/PKA pathway in the closely related species C. albicans and C. tropicalis. View Full-Text
Keywords: protein kinase A; cAMP; Candida albicans; C. tropicalis; hyphal growth; white-opaque switching protein kinase A; cAMP; Candida albicans; C. tropicalis; hyphal growth; white-opaque switching
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lin, C.-J.; Chen, Y.-L. Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis. J. Fungi 2018, 4, 68.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top