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Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis

Department of Plant Pathology and Microbiology, National Taiwan University, 10617 Taipei, Taiwan
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J. Fungi 2018, 4(2), 68; https://doi.org/10.3390/jof4020068
Received: 27 April 2018 / Revised: 28 May 2018 / Accepted: 7 June 2018 / Published: 8 June 2018
(This article belongs to the Special Issue Candida and Candidiasis)
Fungal species undergo many morphological transitions to adapt to changing environments, an important quality especially in fungal pathogens. For decades, Candida albicans has been one of the most prevalent human fungal pathogens, and recently, the prevalence of Candida tropicalis as a causative agent of candidiasis has increased. In C. albicans, the ability to switch between yeast and hyphal forms is thought to be a key virulence factor and is regulated by multiple signaling cascades—including the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), calcineurin, high-osmolarity glycerol (HOG), and mitogen-activated protein kinases (MAPK) signaling pathways—upon receiving environmental cues. The cAMP/PKA signaling pathway also triggers white-opaque switching in C. albicans. However, studies on C. tropicalis morphogenesis are limited. In this minireview, we discuss the regulation of the yeast-hypha transition, virulence, and white-opaque switching through the cAMP/PKA pathway in the closely related species C. albicans and C. tropicalis. View Full-Text
Keywords: protein kinase A; cAMP; Candida albicans; C. tropicalis; hyphal growth; white-opaque switching protein kinase A; cAMP; Candida albicans; C. tropicalis; hyphal growth; white-opaque switching
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Lin, C.-J.; Chen, Y.-L. Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis. J. Fungi 2018, 4, 68.

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