MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method
by
Andrew M. Borman *, Mark Fraser, Michael D. Palmer, Adrien Szekely, Marian Houldsworth, Zoe Patterson and Elizabeth M. Johnson
Andrew M. Borman *, Mark Fraser, Michael D. Palmer, Adrien Szekely, Marian Houldsworth, Zoe Patterson and Elizabeth M. Johnson
Public Health England United Kingdom, Mycology Reference Laboratory, Myrtle Road, Bristol BS2 8EL, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Ana Alastruey-Izquierdo and Stéphane Ranque
J. Fungi 2017, 3(2), 27; https://doi.org/10.3390/jof3020027
Received: 2 May 2017 / Revised: 23 May 2017 / Accepted: 24 May 2017 / Published: 31 May 2017
(This article belongs to the Special Issue Antifungal Susceptibility Testing)
For filamentous fungi (moulds), species-specific interpretive breakpoints and epidemiological cut-off values (ECVs) have only been proposed for a limited number of fungal species–antifungal agent combinations, with the result that clinical breakpoints are lacking for most emerging mould pathogens. In the current study, we have compiled minimum inhibitory concentration (MIC) data for 4869 clinical mould isolates and present full MIC distributions for amphotericin B, itraconazole, voriconazole, posaconazole, and caspofungin with these isolates which comprise 20 species/genera. In addition, we present the results of an assessment of the fungicidal activity of these same five antifungal agents against a panel of 123 mould isolates comprising 16 of the same species.
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Keywords:
filamentous fungi; susceptibility testing; ECVs; amphotericin B; itraconazole; posaconazole; voriconazole; caspofungin; fungicidal; wild-type distributions
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MDPI and ACS Style
Borman, A.M.; Fraser, M.; Palmer, M.D.; Szekely, A.; Houldsworth, M.; Patterson, Z.; Johnson, E.M. MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method. J. Fungi 2017, 3, 27.
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