Malignant Transformation in Diabetic Foot Ulcers—Case Reports and Review of the Literature
Abstract
:1. Introduction
1.1. Pathophysiology in Chronic Wounds
1.2. History of Marjolin’s Ulcer
1.3. Attributes of Marjolin’s Ulcer
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- nodule or verrucous formation;
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- induration;
- -
- everted margins;
- -
- excessive granulation tissue;
- -
- increase in extent during time;
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- contact bleeding;
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- absent tendency of healing within 3 months or more.
1.4. Squamous Cell Carcinoma in Chronic Ulcers
1.5. Diagnostic in MU
1.6. Treatment Options in MU
2. Patient’s Characteristics
2.1. Case 1
2.2. Case 2
3. Clinical Findings and Treatment
3.1. Case 1
3.2. Case 2
4. Outcome and Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
CHD | coronary heart disease |
DFU | diabetic foot ulcer |
EGF | epithelial growth factor |
FGF | fibroblast growth factor |
HGF | hepatocyte growth factor |
IL | interleukin |
MMP | matrix metalloproteinase |
MR-imagine/MRI | Magnet-resonance imaging, MRT |
MU | Marjolin’s ulcer |
PAD | peripheral arterial disease |
PDGF | platelet derived growth factor |
SCC | squamous cell cancer |
TGF | transforming growth factor |
TIMP | inhibitors of MMP |
TNF | tumor necrosis factor |
BCC | basal cell carcinoma |
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Criteria | Meaning |
---|---|
T1 | Tumor extent ≤2 cm |
T2 | Tumor extent >2 cm and <5 cm |
T3 | Tumor extent ≥5 cm |
T4 | Tumor affects deeper structures such as bone, cartilage or muscle |
N0 | Not any lymph node metastases. |
N1 | Local lymph node metastases |
M0 | Not any metastases |
M1 | Distant metastases |
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Dörr, S.; Lucke-Paulig, L.; Vollmer, C.; Lobmann, R. Malignant Transformation in Diabetic Foot Ulcers—Case Reports and Review of the Literature. Geriatrics 2019, 4, 62. https://doi.org/10.3390/geriatrics4040062
Dörr S, Lucke-Paulig L, Vollmer C, Lobmann R. Malignant Transformation in Diabetic Foot Ulcers—Case Reports and Review of the Literature. Geriatrics. 2019; 4(4):62. https://doi.org/10.3390/geriatrics4040062
Chicago/Turabian StyleDörr, Stefan, Lara Lucke-Paulig, Christian Vollmer, and Ralf Lobmann. 2019. "Malignant Transformation in Diabetic Foot Ulcers—Case Reports and Review of the Literature" Geriatrics 4, no. 4: 62. https://doi.org/10.3390/geriatrics4040062