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In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains

1
Centro Universitário Metodista–IPA, Rua Coronel Joaquim Pedro Salgado, 80, Porto Alegre 90420-060, RS, Brazil
2
Univates, Programa de Pós-Graduação em Biotecnologia, Rua Avelino Tallini, 171, Lajeado 95900-000, RS, Brazil
*
Author to whom correspondence should be addressed.
Beverages 2018, 4(4), 99; https://doi.org/10.3390/beverages4040099
Received: 15 November 2018 / Revised: 28 November 2018 / Accepted: 30 November 2018 / Published: 4 December 2018
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Abstract

Considering that grape juice has high levels of phenolic compounds that produce beneficial physiological effects, important for the maintenance of redox balance, the aim of this study was to evaluate the in vitro neuroprotective effect of purple grape juice on the oxidative damage caused by temozolomide (TMZ) in the cerebral cortex, hippocampus, and cerebellum of Wistar rats. In pre-incubation, TMZ increased thiobarbituric acid reactive substances (TBARS) in the cerebral cortex and cerebellum, enhanced protein oxidation in all tissues studied, increased superoxide dismutase (SOD) activity in the hippocampus, decreased SOD activity in the cerebellum, and enhanced catalase (CAT) activity in the cerebral cortex and cerebellum. In co-incubation, there was enhanced protein oxidation in the cerebral cortex and cerebellum, decreased SOD activity in the cerebellum, inhibition of CAT activity in the hippocampus, and increased CAT activity in the cerebellum. Purple grape juice improved these oxidative alterations. Therefore, the intake of grape juice might have a protective effect against diseases that affect the oxidative status of the central nervous system. View Full-Text
Keywords: grapes; temozolomide; brain; oxidative stress; antioxidant grapes; temozolomide; brain; oxidative stress; antioxidant
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Gabardo, T.; Frusciante, M.R.; Pereira Marinho, J.; Dos Santos, M.; Abujamra, A.L.; Dani, C.; Funchal, C. In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains. Beverages 2018, 4, 99.

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