Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices
1
Center for Biomedical Engineering and Rehabilitation Science, Ruston, LA 71270, USA
2
School of Biological Sciences, Louisiana Tech University, Ruston, LA 71272, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Bioengineering 2017, 4(4), 96; https://doi.org/10.3390/bioengineering4040096
Received: 4 October 2017
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Revised: 11 December 2017
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Accepted: 12 December 2017
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Published: 15 December 2017
(This article belongs to the Special Issue Advances in 3D Printing of Biomaterials)
Previous studies have established halloysite nanotubes (HNTs) as viable nanocontainers capable of sustained release of a variety of antibiotics, corrosion agents, chemotherapeutics and growth factors either from their lumen or in outer surface coatings. Accordingly, halloysite nanotubes (HNTs) hold great promise as drug delivery carriers in the fields of pharmaceutical science and regenerative medicine. This study explored the potential of 3D printing drug doped HNT constructs. We used a model drug, gentamicin (GS) and polylactic acid (PLA) to fabricate GS releasing disks, beads, and pellets. Gentamicin was released from 3D printed constructs in a sustained manner and had a superior anti-bacterial growth inhibition effect that was dependent on GS doping concentration. While this study focused on a model drug, gentamicin, combination therapy is possible through the fabrication of medical devices containing HNTs doped with a suite of antibiotics or antifungals. Furthermore, tailored dosage levels, suites of antimicrobials, delivered locally would reduce the toxicity of individual agents, prevent the emergence of resistant strains, and enable the treatment of mixed infections.
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Keywords:
3D printing; drug delivery; halloysite nanotubes; nanotechnology
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MDPI and ACS Style
Weisman, J.A.; Jammalamadaka, U.; Tappa, K.; Mills, D.K. Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices. Bioengineering 2017, 4, 96. https://doi.org/10.3390/bioengineering4040096
AMA Style
Weisman JA, Jammalamadaka U, Tappa K, Mills DK. Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices. Bioengineering. 2017; 4(4):96. https://doi.org/10.3390/bioengineering4040096
Chicago/Turabian StyleWeisman, Jeffery A., Udayabhanu Jammalamadaka, Karthik Tappa, and David K. Mills. 2017. "Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices" Bioengineering 4, no. 4: 96. https://doi.org/10.3390/bioengineering4040096
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