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Open AccessArticle

Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions

1
Food Technology, Faculty of Engineering LTH, Lund University, PO Box 124, S-221 00 Lund, Sweden
2
School of Chemistry, Faculty of Pure and Natural Sciences, Universidad Mayor de San Andrés, PO Box 303, La Paz, Bolivia
3
Biotechnology, Faculty of Engineering LTH, Lund University, PO Box 117, S-221 00 Lund, Sweden
*
Author to whom correspondence should be addressed.
The paper is a part of Atma-Sol Bustos PhD thesis.
Foods 2020, 9(6), 777; https://doi.org/10.3390/foods9060777
Received: 28 April 2020 / Revised: 7 June 2020 / Accepted: 9 June 2020 / Published: 11 June 2020
Myricetin, a flavonoid found in the plant kingdom, has previously been identified as a food molecule with beneficial effects against obesity. This property has been related with its potential to inhibit lipase, the enzyme responsible for fat digestion. In this study, we investigate the interaction between myricetin and lipase under simplified intestinal conditions from a colloidal point of view. The results show that myricetin form aggregates in aqueous medium and under simplified intestinal condition, where it was found that lipase is in its monomeric form. Although lipase inhibition by myricetin at a molecular level has been reported previously, the results of this study suggest that myricetin aggregates inhibit lipase by a sequestering mechanism as well. The size of these aggregates was determined to be in the range of a few nm to >200 nm. View Full-Text
Keywords: myricetin aggregates; lipase inhibition; intestinal conditions; sequestering mechanism myricetin aggregates; lipase inhibition; intestinal conditions; sequestering mechanism
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MDPI and ACS Style

Bustos, A.-S.; Håkansson, A.; Linares-Pastén, J.A.; Nilsson, L. Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions. Foods 2020, 9, 777.

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