Synthesis and Characterization of the Germathioacid Chloride Coordinated by an N-Heterocyclic Carbene §

Carboxylic acid chlorides are useful substrates in organic chemistry. Many germanium analogues of carboxylic acid chloride have been synthesized so far. Nevertheless, all of the reported germathioacid chlorides use bidentate nitrogen ligands and contain germanium-nitrogen bonds. Our group synthesized germathioacid chloride, Ge(S)Cl{C6H3-2,6-Tip2}(Im-i-Pr2Me2), using N-heterocyclic carbene (Im-i-Pr2Me2). As a result of density functional theory (DFT) calculation, it was found that electrons are localized on sulfur, and the germanium-sulfur bond is a single bond with a slight double bond property.


Introduction
Heavier analogues of multiple bonded organic species have attracted the interest of many chemists in terms of comparisons for structures, physical properties, and reactivities [1][2][3].For a long time, multiple bonds of higher row main group elements have been thought to be unstable due to the small overlap of π-orbitals.However, a breakthrough occurred in 1981 with the achievement of the synthesis of Si=C [4], S=Si [5], and P=P [6] bonds by taking advantage of the protection by bulky substituents.They have also opened a breach in the elemental bond theory.In recent years, increasing interest in the chemistry of double-bonded species between group 14 and 16 elements has emerged, since carbonyl compounds represent one of the most important functionalities in chemistry [3,7,8].Among them, focusing on the double bond of germanium and sulfur, that is, germanetione, there is a history of research as shown below (Figure 1).In 1989, Veith and co-workers synthesized germanethione (I) (germanium urea), which was stabilized by nitrogen ligand, and determined its structure by X-ray analysis [9].After that, Okazaki, Tokitoh and co-workers isolated the first diarylgermanethione (II) using a very bulky protecting group and determined its structure [10,11].Meanwhile, in organic chemistry, carboxylic acid chloride is an important compound group that serves as a substrate for the Friedel-Crafts reaction or Rosenmund reduction.The development of heavy analogues of carboxylic acid chloride was achieved by Roesky's group in 2002.They succeeded in the synthesis and isolation of the target substance (III) by thermodynamic stabilization using a π-diketiminate ligand [12].Following their work, several results of germathioacid chloride syntheses using a bidentate nitrogen ligand have been reported (IV-VII) [13][14][15][16].Nevertheless, due to the limitation of the use of a bidentate nitrogen ligand, all germathioacid chloride syntheses reported so far are only those in which nitrogen atoms and germanium are bonded; thus, all are heavy analogues of carbamoyl chloride.
In this paper, we report the synthesis and structure of germathioacid chloride stabilized with an NHC ligand.Among germathioacid chlorides, this is the first example containing a germanium carbon bond.We have clarified the bonding state of the germathioacid chloride by density functional theory (DFT) calculation.

As
shown in Scheme 1, 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (Im-i-Pr2Me2)-substituted chlorogermylene (2) was prepared by the reaction of the Ge(Cl){C6H3-2,6-Tip2} (1) with an equivalent amount of Im-i-Pr2Me2 in dry toluene.This synthesis method was based on Filippou's method [17].Compound 2 was treated with sulfur element in dry benzene-d6 at ambient temperature for 3 days, and after work up, the germathioacid chloride coordinated by Im-i-Pr2Me2 (3), Ge(S)Cl{C6H3-2,6-Tip2}(Im-i-Pr2Me2) was obtained in 31% yield.The germathioacid chloride (3) was characterized by NMR spectroscopy together with elemental analysis, and the structure of 3 was finally determined by single-crystal X-ray analysis (Figure 2).In 1989, Veith and co-workers synthesized germanethione (I) (germanium urea), which was stabilized by nitrogen ligand, and determined its structure by X-ray analysis [9].After that, Okazaki, Tokitoh and co-workers isolated the first diarylgermanethione (II) using a very bulky protecting group and determined its structure [10,11].Meanwhile, in organic chemistry, carboxylic acid chloride is an important compound group that serves as a substrate for the Friedel-Crafts reaction or Rosenmund reduction.The development of heavy analogues of carboxylic acid chloride was achieved by Roesky's group in 2002.They succeeded in the synthesis and isolation of the target substance (III) by thermodynamic stabilization using a π-diketiminate ligand [12].Following their work, several results of germathioacid chloride syntheses using a bidentate nitrogen ligand have been reported (IV-VII) [13][14][15][16].Nevertheless, due to the limitation of the use of a bidentate nitrogen ligand, all germathioacid chloride syntheses reported so far are only those in which nitrogen atoms and germanium are bonded; thus, all are heavy analogues of carbamoyl chloride.
In this paper, we report the synthesis and structure of germathioacid chloride stabilized with an NHC ligand.Among germathioacid chlorides, this is the first example containing a germanium carbon bond.We have clarified the bonding state of the germathioacid chloride by density functional theory (DFT) calculation.

Synthesis and Structure of Germathioacid Chloride 3
As shown in Scheme 1, 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (Im-i-Pr 2 Me 2 )-substituted chlorogermylene (2) was prepared by the reaction of the Ge(Cl){C 6 H 3 -2,6-Tip 2 } (1) with an equivalent amount of Im-i-Pr 2 Me 2 in dry toluene.This synthesis method was based on Filippou's method [17].Compound 2 was treated with sulfur element in dry benzene-d 6 at ambient temperature for 3 days, and after work up, the germathioacid chloride coordinated by Im-i-Pr 2 Me 2 (3), Ge(S)Cl{C 6 H 3 -2,6-Tip 2 }(Im-i-Pr 2 Me 2 ) was obtained in 31% yield.The germathioacid chloride (3) was characterized by NMR spectroscopy together with elemental analysis, and the structure of 3 was finally determined by single-crystal X-ray analysis (Figure 2).Crystals suitable for X-ray crystallographic analysis of 3 were obtained from benzene-d6.Compound (3) crystallized in the monoclinic crystal system with P21/n space group.Compound (3) is the first example of germathioacid chloride in which the Ge atom is not coordinated to an N atom.The germanium center is bonded to the terphenyl ligand, chlorine, and sulfur atoms, and the other site is occupied by the NHC (Im-i-Pr2Me2), resulting in a tetrahedral geometry at the germanium center.The Ge-S bond of 3 (2.0846(8)Å) is slightly longer than the Ge=S bonds stabilized by N ligands (ranging from 2.048(2) Å to 2.066(1) Å [12][13][14][15][16]), but shorter than the Ge-S single bond (2.239(1) Å [18]) (Figure 1).This result suggests that the Ge-S bond has a partial double bond character.Crystals suitable for X-ray crystallographic analysis of 3 were obtained from benzene-d6.Compound (3) crystallized in the monoclinic crystal system with P21/n space group.Compound (3) is the first example of germathioacid chloride in which the Ge atom is not coordinated to an N atom.The germanium center is bonded to the terphenyl ligand, chlorine, and sulfur atoms, and the other site is occupied by the NHC (Im-i-Pr2Me2), resulting in a tetrahedral geometry at the germanium center.The Ge-S bond of 3 (2.0846(8)Å) is slightly longer than the Ge=S bonds stabilized by N ligands (ranging from 2.048(2) Å to 2.066(1) Å [12][13][14][15][16]), but shorter than the Ge-S single bond (2.239(1) Å [18]) (Figure 1).This result suggests that the Ge-S bond has a partial double bond character.Crystals suitable for X-ray crystallographic analysis of 3 were obtained from benzene-d 6 .Compound (3) crystallized in the monoclinic crystal system with P2 1 /n space group.Compound (3) is the first example of germathioacid chloride in which the Ge atom is not coordinated to an N atom.The germanium center is bonded to the terphenyl ligand, chlorine, and sulfur atoms, and the other site is occupied by the NHC (Im-i-Pr 2 Me 2 ), resulting in a tetrahedral geometry at the germanium center.The Ge-S bond of 3 (2.0846(8)Å) is slightly longer than the Ge=S bonds stabilized by N ligands (ranging from 2.048(2) Å to 2.066(1) Å [12][13][14][15][16]), but shorter than the Ge-S single bond (2.239(1) Å [18]) (Figure 1).This result suggests that the Ge-S bond has a partial double bond character.

Density Functional Theory Studies on the Germathioacid Chloride 3
In order to better understand the characteristics of germathioacid chloride 3, a density functional theory (DFT) calculation (B3LYP/6-31G(d,p)) was carried out [19].The optimized structure of the germathioacid chloride 3 well-reproduced the structure experimentally observed in single-crystal X-ray analysis (Figure 2 and Figure S3).The natural population analysis (NPA) showed that a large positive charge was located on Ge (+1.240), and the S atom and Cl atom had negative charges of −0.762 and −0.456, respectively.The calculated IR stretching frequency of G=S bond was 469.64 cm −1 .
As shown in Figure 3, the highest occupied molecular orbital (HOMO) and HOMO − 1 were predominantly localized on the S atom, which should correspond to non-bonding pair electrons (Figure 3a,b), and an π-bond between the Ge atom and the S atom was not observed.The molecular orbitals (MOs), which should correspond to the σ-bonds of the Ge-S/Ge-C(NHC), and the σ * -bonds of the Ge-S/Ge-Cl were also observed in HOMO − 1/HOMO − 29 (Figure 3c,d) and LUMO + 8, respectively (Figure 3e).These results suggest that the Ge-S bond would have a single bond character.On the other hand, the value of the Wiberg Bond Index (WBI) of Ge-S is 1.367, implying that the Ge-S bond has a partial double bond character.Although the value of WBI seemingly contradicted the analysis of the MOs, the second-order perturbation theory analysis rationalized the Ge-S bond feature; both non-bonding pair electrons localized on the S atom donated stabilization energy to the σ * -orbitals of the Ge-Cl (23.39 kcal/mol), Ge-C(Ar Tip ) (11.23 kcal/mol), and Ge-C(NHC) (16.51 kcal/mol), respectively, and the secondary orbital interaction should be attributed to the partial π-bonding nature between the Ge-S bond in the WBI analysis.These results indicate that the Ge-S bond is a single bond with a partial double bond character, which is in good agreement with observation that the bond length (2.0846(8) Å) in the germathioacid chloride 3 (Figure 2) is shorter than that of the single bond of Ge-S (2.239(1)Å) [18], and longer than that of the Ge-S double bond (2.048(2) Å to 2.066(1) Å) [12][13][14][15][16].

Density Functional Theory Studies on the Germathioacid Chloride 3
In order to better understand the characteristics of germathioacid chloride 3, a density functional theory (DFT) calculation (B3LYP/6-31G(d,p)) was carried out [19].The optimized structure of the germathioacid chloride 3 well-reproduced the structure experimentally observed in single-crystal X-ray analysis (Figures 2 and S3).The natural population analysis (NPA) showed that a large positive charge was located on Ge (+1.240), and the S atom and Cl atom had negative charges of −0.762 and −0.456, respectively.The calculated IR stretching frequency of G=S bond was 469.64 cm -1 .
As shown in Figure 3, the highest occupied molecular orbital (HOMO) and HOMO − 1 were predominantly localized on the S atom, which should correspond to non-bonding pair electrons (Figure 3a,b), and an π-bond between the Ge atom and the S atom was not observed.The molecular orbitals (MOs), which should correspond to the σ-bonds of the Ge-S/Ge-C(NHC), and the σ * -bonds of the Ge-S/Ge-Cl were also observed in HOMO − 1/HOMO − 29 (Figure 3c,d) and LUMO + 8, respectively (Figure 3e).These results suggest that the Ge-S bond would have a single bond character.On the other hand, the value of the Wiberg Bond Index (WBI) of Ge-S is 1.367, implying that the Ge-S bond has a partial double bond character.Although the value of WBI seemingly contradicted the analysis of the MOs, the second-order perturbation theory analysis rationalized the Ge-S bond feature; both non-bonding pair electrons localized on the S atom donated stabilization energy to the σ * -orbitals of the Ge-Cl (23.39 kcal/mol), Ge-C(ArTip) (11.23 kcal/mol), and Ge-C(NHC) (16.51 kcal/mol), respectively, and the secondary orbital interaction should be attributed to the partial π-bonding nature between the Ge-S bond in the WBI analysis.These results indicate that the Ge-S bond is a single bond with a partial double bond character, which is in good agreement with observation that the bond length (2.0846(8) Å) in the germathioacid chloride 3 (Figure 2) is shorter than that of the single bond of Ge-S (2.239(1)Å) [18], and longer than that of the Ge-S double bond (2.048(2) Å to 2.066(1) Å) [12][13][14][15][16]. Based on experiments and calculation results, compound 3 could be an intermediate property between 3′ and 3″ (Figure 4).Further investigation will be carried out in the future.Based on experiments and calculation results, compound 3 could be an intermediate property between 3 and 3" (Figure 4).Further investigation will be carried out in the future.

Density Functional Theory Studies on the Germathioacid Chloride 3
In order to better understand the characteristics of germathioacid chloride 3, a density functional theory (DFT) calculation (B3LYP/6-31G(d,p)) was carried out [19].The optimized structure of the germathioacid chloride 3 well-reproduced the structure experimentally observed in single-crystal X-ray analysis (Figures 2 and S3).The natural population analysis (NPA) showed that a large positive charge was located on Ge (+1.240), and the S atom and Cl atom had negative charges of −0.762 and −0.456, respectively.The calculated IR stretching frequency of G=S bond was 469.64 cm -1 .
As shown in Figure 3, the highest occupied molecular orbital (HOMO) and HOMO − 1 were predominantly localized on the S atom, which should correspond to non-bonding pair electrons (Figure 3a,b), and an π-bond between the Ge atom and the S atom was not observed.The molecular orbitals (MOs), which should correspond to the σ-bonds of the Ge-S/Ge-C(NHC), and the σ * -bonds of the Ge-S/Ge-Cl were also observed in HOMO − 1/HOMO − 29 (Figure 3c,d) and LUMO + 8, respectively (Figure 3e).These results suggest that the Ge-S bond would have a single bond character.On the other hand, the value of the Wiberg Bond Index (WBI) of Ge-S is 1.367, implying that the Ge-S bond has a partial double bond character.Although the value of WBI seemingly contradicted the analysis of the MOs, the second-order perturbation theory analysis rationalized the Ge-S bond feature; both non-bonding pair electrons localized on the S atom donated stabilization energy to the σ * -orbitals of the Ge-Cl (23.39 kcal/mol), Ge-C(ArTip) (11.23 kcal/mol), and Ge-C(NHC) (16.51 kcal/mol), respectively, and the secondary orbital interaction should be attributed to the partial π-bonding nature between the Ge-S bond in the WBI analysis.These results indicate that the Ge-S bond is a single bond with a partial double bond character, which is in good agreement with observation that the bond length (2.0846(8) Å) in the germathioacid chloride 3 (Figure 2) is shorter than that of the single bond of Ge-S (2.239(1)Å) [18], and longer than that of the Ge-S double bond (2.048(2) Å to 2.066(1) Å) [12][13][14][15][16]. Based on experiments and calculation results, compound 3 could be an intermediate property between 3′ and 3″ (Figure 4).Further investigation will be carried out in the future.
The Fourier transformation nuclear magnetic resonance (NMR) spectra were obtained using JEOL JNM-ECS 300 ( 1 H at 300 MHz, 13 C at 75 MHz) and JEOL JNM-ECA 600 ( 1 H at 600 MHz, 13 C at 151 MHz) NMR instruments (JEOL, Tokyo, Japan).For 1 H-NMR, chemical shifts are reported as δ units (ppm) relative to SiMe 4 and the residual solvents peaks were used as standards.Analysis by electron impact mass spectrometry (EI-MS) was performed on a SHIMADZU GCMS-QP2010SE/DI2010 (SHIMADZU, Kyoto, Japan).Elemental analyses were performed by the Center for Material Research by Instrumental Analysis (CIA), Gunma University, Japan.

Figure 1 .
Figure 1.Ge=S-containing compounds and Ge=S bond length.