Effect of Gas-Liquid Contact Intensiﬁcation on Heat and Mass Transfer in Deﬂector and Rod Bank Desulfurization Spray Tower

: The deﬂector and the rod bank are commonly used to optimize ﬂue gas distribution in the original spray tower (OST) of a wet ﬂue gas desulfurization system (WFGD). In this paper, the internal optimization mechanism of the deﬂector desulfurization spray tower (DST) and the rod bank desulfurization spray tower (RBST) are studied. Based on the Euler–Lagrange method, the standard k- ε turbulence model, an SO 2 absorption model and a porous media model, the numerical simulation of the desulfurization spray tower is carried out with the veriﬁcation of the model rationality. The results show that there are gas-liquid contact intensiﬁcation effects in DST and RBST. Compared with OST, gas-liquid contact intensiﬁcation enhances the heat and mass transfer effects of DST and RBST. The temperature difference between inlet and outlet of ﬂue gas increased by 3.3 K and the desulfurization efﬁciency of DST increased by 1.8%; the pressure drop decreased by 37 Pa. In RBST, the temperature difference between the ﬂue gas inlet and outlet increased by 5.3 K and the desulfurization efﬁciency increased by 3.6%; the pressure drop increased by 33 Pa.


Introduction
Wet flue gas desulfurization (WFGD) is used to treat most of the flue gas produced by the power and heat production and supply industries in China [1]. Through the countercurrent contact between acidic flue gas and alkaline slurry, the acidic gas is absorbed by the slurry, thus achieving the purpose of removing sulfur dioxide [2,3]. The operating cost of WFGD is mainly composed of electricity consumption, alkali consumption, water consumption, labor cost and equipment maintenance. The desulfurization efficiency can be effectively improved by increasing the amount of slurry circulation, but the amount of power required by the slurry circulation pump is greatly increased, thus increasing the electricity consumption. The increase in the operating resistance of the desulfurization spray tower will cause the induced draft fan to use more power, so the electricity consumption will also increase. Since the desulfurization spray tower is the main equipment of WFGD [4], the operating parameters, structure design and hydrodynamic performance analysis of the desulfurization spray tower are particularly important.
In the desulfurization spray tower, the non-uniformity of the flue gas flow field is common, due to the radial flow direction of the flue gas [5]. It is a common method to optimize the uniformity of the flue gas flow field by adjusting the operating parameters in the tower. Deng [6] optimized the flow field through the flow rate of the flue gas inlet and continued through the uniformity index to evaluate the uniformity of the flow field. Wang [7] proposed a detailed design scheme by studying the flow field uniformity of the desulfurization spray tower with different spray layers. Wang [8] simulated the gas-liquid flow field of the desulfurization spray tower in full size by ANSYS CFX software and concluded that the combined flow field of 2nd and 3rd spray level is the most uniform. In addition to adjusting operating parameters, changing the tower structure is also an optimization method. Xiao [9] simulated PCF (a wet flue gas desulfurization absorber) with different inlet structure forms, and chose the best PCF inlet structure to reduce design time and economic cost.
However, the adjustment of operating parameters may increase the operating costs. In addition, changing the structure of the tower is not viable in the existing equipment. With the improvement of environmental protection requirements and the harsh requirements of engineering reconstruction, installing special structures has become an important and feasible flow field optimization method. Chou [10] added perforated sieve trays into the desulfurization spray tower with the consideration of chemical effects and concluded that the perforated sieve trays can increase the desulfurization efficiency. Zhen [11] optimized the flow field by adding a FPC (flow pattern controlling) device to the desulfurization spray tower. Compared with the common spray tower without a perforated plate, the desulfurization performance of the FPC device is significantly improved. Both the deflector [12] and the rod bank [13] are important structures for the development of the flow field of the desulfurization spray tower, which are used to optimize the flow field uniformity and strengthen the mass transfer. Research on the flow field distribution of these two structures has mainly focused on the distribution of flue gas, while the liquid distribution has not been analyzed in detail. Although Wang [14] proposed the droplet self-adjustment to explain the gas-liquid interaction, it is not clear how the two structures regulate the gas-liquid contact.
The disadvantage of high energy consumption of WFGD in traditional coal-fired power plants is increasingly prominent [15]. Therefore, the recovery of flue gas residual heat has become the focus of energy-saving transformation. In WFGD, most of the residual heat of flue gas is transferred to the slurry. The study of two kinds of heat transfer is beneficial to provide ideas for the subsequent recovery of flue gas residual heat. However, the analysis of special structures in previous studies is not comprehensive, especially the analysis of the gas-liquid two-phaseheat transfer law in a desulfurization spray tower.
Computational fluid dynamics (CFD) is an ideal method for the optimal design of the desulfurization spray tower and for the prediction of flow field distribution. Gasliquid two-phase flow can be simulated by Euler-Euler [16][17][18] and Euler-Lagrange [19,20] methods. It is believed that in some studies liquid exists in the form of liquid film, formed on the surface of the structures with its local volume concentration much higher than 10%, which contributes to the application of the Euler-Euler method [10,14]. However, according to experimental studies, the liquid volume fraction in a large area of the spray tower is less than 5-8% [21]. Comparing with the Euler-Euler method, particles and injection types are modeled strictly and accurately by the Euler-Lagrange method [22]. The Euler-Lagrange method is adopted in this paper to model the two-phase flow in WFGD due to the requirements of accurate analysis of the liquid phase and the gas-liquid phase interaction.
In this paper, a CFD numerical simulation method is used to study the original desulfurization spray tower (OST) of a 330 MW coal-fired unit WFGD system, the deflector desulfurization spray tower (original desulfurization spray tower + deflector) (DST) and the rod bank desulfurization spray tower (original desulfurization spray tower + rod bank), respectively. The flow field under three working conditions is analyzed, the gas-liquid contact intensification in DST and RBST is revealed, and the influence of gas-liquid contact strengthening on heat and mass transfer is discussed. Finally, the operating resistance in each desulfurization spray tower is analyzed.

Governing Equations
In the desulfurization spray tower, there is a complex multiphase flow of gas, liquid and solid, including the mass and heat transfer between the three phases. Flue gas and slurry, which are two main phases in the desulfurization spray tower, are the emphasis of the research. Therefore, the flow in the tower is simplified as the gas-liquid two-phase flow, and the heat and mass transfer between the two phases are considered. Because the volume fraction of the slurry in the desulfurization spray tower is less than 10%, the Euler-Lagrange method is used for the two-phase numerical simulation in this paper. In the Euler-Lagrange method, the flue gas with a higher volume fraction is treated as a continuous phase by the Euler method. The liquid phase is treated as a discrete phase model (DPM) by the Lagrange method. The Lagrange method can accurately track the trajectory of particles and fully consider the interaction between the two phases. In the actual desulfurization spray tower, the slurry exists in the form of droplets through the atomization of the nozzles. In the process of moving, droplets will collide with each other, and the coalescence and rupture of droplets will occur at the same time. In the large-scale calculation domain, the collision, coalescence and rupture processes of droplets can be ignored. Therefore, the model of water droplets established by the Lagrange method can be applied to simulate the liquid phase in the tower, and has been verified [12]. The empirical equation standard k-ε turbulence model is used to simulate the turbulence.

Continuous Phase
The flue gas is regarded as incompressible Newtonian fluid. The governing equations of continuous phase motion are the mass conservation equation and the momentum conservation equation. Since heat and mass transfer processes are taken into simulation, the energy equation and species transport equation are also involved. The solution of a species transport equation for a species predicts the local mass fraction of the species. The equations are listed as follows [23]: where, ρ is fluid density, t is time, v is the velocity, p is static pressure, = τ is the stress tensor, ρ → g is the volume force of gravity, k eff is effective coefficient. S mass is the mass source term, → F is the momentum source term, S h other volumetric heat source, Y i mass fraction of specie i, S i is the rate source term. → J i is the diffusion flux of specie i, which arises due to gradients of concentration and temperature. Fick's law is applied to model mass diffusion due to concentration gradients: where, Sc t = µ t /ρD t , is the turbulent Schmidt number, µ t is the turbulent viscosity, D t is the turbulent diffusivity. D i,m is the mass diffusion coefficient for species i in the mixture, D T,i is the thermal diffusion coefficient.

Discrete Phase Model
The slurry is regarded as a discrete phase. Liquid droplets are regarded as rigid spheres. A force equilibrium integral is applied in ANSYS FLUENT to predict the trajectory of slurry droplets. The force equilibrium is that the inertia of slurry droplets is equal to the force acting on slurry droplets, which can be written as: where, u is the velocity of the fluid phase, u p is the velocity of the particles, µ is the molecular viscosity of the fluid, ρ p is the density of the particles, is the drag force and where, d p is the diameter of the particles, Re is the relative Reynolds number, and C D [24] is a function related to Re: where a 1 , a 2 , and a 3 are constants that apply over several ranges of Re [24].

Mass Exchange
In the calculation process, the absorption process of SO 2 is considered. The absorption of SO 2 is added as the source term by the user-defined functions (UDF). The mass source term can be expressed as: The SO 2 absorption model is established according to the two-film theory, and the mass transfer rate of SO 2 is expressed as [12]: where, p g,SO 2 is the partial pressure of SO 2 in flue gas, C l,SO 2 is the concentration of SO 2 in the droplet, H SO 2 is Henry's constant [25]: where, T p is the temperature of the droplet. K total is the total mass transfer coefficient, which is jointly affected by the mass transfer rates of SO 2 on the gas side and liquid side, respectively. Its expression is written as follows [12]: where, E SO 2 is the enhancement factor. K SO 2 ,g is the mass transfer coefficient if the gas can be obtained by the following correlation [21]: where, Sh is the Nusselt number. D g is the diffusion coefficient of SO 2 in the gas phase. S C is schmidt number of gas. K SO 2 ,l is the mass transfer coefficient if liquid side [26]: where, σ is the solution surface tension, D l is the diffusion coefficient of SO 2 in the liquid phase, m p is the quality of the droplet, T l is the temperature of the solution.

Momentum Exchange
The momentum exchange from the continuous phase to the discrete phase is obtained by checking the momentum change of a particle through each control volume in the model, and the source phase of the momentum exchange is expressed as: where, . m p is mass flow rate of the particle.

Heat Exchange
The interphase heat transfer is considered as a simple heat balance. Particle temperature is associated with convective heat transfer. After the two-phase contact and heat transfer, the gas temperature dropped significantly, which is the same as the slurry temperature. At the same time, the evaporation water in the column accounted for 0.61% of the total spray slurry. Therefore, the evaporation process of the droplet can be ignored [27]. There is no supersaturated environment for water vapor in the tower, so the condensation process can also be ignored. In the whole wet flue gas desulfurization process, the flue gas temperature is low, and the flue gas inlet temperature is up to 140 • C, therefore, thermal radiation can be ignored since strong thermal radiation will not occur. The interphase heat transfer equation is: where, c p is droplet heat capacity, h is convective heat transfer coefficient, T ∞ is temperature of continuous phase.

Porous Media Model
The structure of the mist eliminator is complex, and thus can be simplified by using a porous media model. The model defines a cell region in which the porous media model is applied and the pressure loss in the flow is determined by the input described in the momentum equation of the porous media. Porous media are modeled by adding the momentum source term to the standard fluid flow equation. The source term is composed of two parts: the viscous loss term (Darcy equation) and the inertia loss term. The equation can be expressed as: where, S i is a momentum equation of x (y, or z) of the source, |v| is the size of the velocity, C, D is stipulated by the matrix. For homogeneous porous media: In this time, D is the 1/α, C is the C 2 . α is the permeability, α = 320,000, C 2 is the inertial resistance coefficient, C 2 = 71.

Computational Domain and Boundary Condition
In Figure 1, the flue gas enters the domain through the inlet, and then goes through the rectifying effect of the deflectors or the rod bank. The flue gas contacts the spray slurry countercurrent and flows out of the outlet through a defined porous medium zone. In Figure 2, a 3D model (1:1 scale) is established for OST flow field area, DST and RBST, of which the design ideas are derived from literatures [12,14]. There are two deflectors. Its shape is two incomplete elliptical arcs. The bottom of the first deflector is installed at the middle height of the flue gas inlet, and the bottom of the second deflector is installed at the intersection of the center of the tower and the bottom of the inlet. The rod bank has two layers, which are staggered. The distance between the two layers of the rod bank is 800 mm, and the distance between the lower layer of the rod groups and the upper part of the inlet is 1200 mm. Horizontal spacing of adjacent rods is 750 mm. The diameter of the rod is 250 mm. The flue gas flow field adopts velocity inlet and pressure outlet, the solid boundary is set as a non-slip wall: where, u inlet is flue gas velocity at the inlet, Q is flue gas flow, A is cross-sectional area of inlet, p outlet is pressure at the outlet of flow field, u wall is velocity at the wall. The temperature of flue gas is equivalent to that of slurry after cooling, at about 50 • C. Therefore, the physical properties of flue gas at this time are taken as calculation parameters. Flue gas parameters and slurry parameters are shown in Table 1. The droplet size in simulation is the median particle size of spray atomized droplets, which value equals to 3 mm. The slurry is injected from the spray surface, and the collision of droplets with the tower wall, the deflector and the rod bank is simulated by the wallparticle reflection model. The tangential and normal reflection coefficients are set as 0.2. The boundary conditions of the collision between the droplets and the slurry plane are set as trap, and the boundary conditions of the droplets at the inlet and outlet of the flue gas are set as escape. The SIMPLE algorithm is used to solve the problem.

Grid Generation and Independence Verification
Owing to the complex structures of the deflector and the rod bank, a tetrahedral unstructured grid is used as a whole. The boundary layer grids are used to encrypt the tower wall, the deflector and the rod bank, which are shown in Figure 3. For the OST, 0.5 million, 1.5 million, and 2.5 million grids are generated. For the DST, 0.9 million, 1.9 million, and 2.9 million grids are generated. For the RBST, 1.2 million, 3.2 million, and 4.2 million grids are generated. The simulation results are shown in Table 2. When the grid number of the OST is 1.5 million, the grid number of the DST is 1.9 million, and the RBST is 3.2 million, the temperature difference, pressure drop and desulfurization efficiency of the calculation result are all stable.

Experimental Method
The actual process flow of a WFGD system of a 330 MW coal-fired unit is shown in Figure 4. The process is mainly composed of a flue gas circulation system and a slurry circulation system. In the flue gas circulation system, the draught fan provides power for the flue gas to enter the crude desulfurization section from the inlet. Then the flue gas and spray slurry are in countercurrent contact to remove SO 2 . In addition, the entrainment small droplets in the flue gas are removed through the mist eliminator. Finally, it flows out of the crude desulfurization section outlet. The flue gas continues to move upward, and the rest of SO 2 is removed through the fine desulfurization section to meet the discharge standard. After being heated by the steam heater, the flue gas flows out of the tower outlet. In the slurry circulation system, the slurry is injected into the tower from the spray layer by the circulation pump and then collected into the slurry pool. The slurry is replenished regularly, and the role of the slurry agitator is to prevent precipitation. The spray tower is 13 m in diameter, and the spray layer is two layers (horizontal height of 5.2 m and 7 m from the entrance center). There are 240 nozzles in each spray layer, as shown in Figure 5b,c. The operation parameters of the tower are summarized in Table 3.   Measuring probes are set at the flue gas inlet and the crude desulfurization outlet to obtain pressure, temperature and SO 2 concentration data, respectively. A comparison between numerical results and experimental data is shown in Table 4. The results show that the errors of temperature difference, pressure difference and desulfurization efficiency are all less than 10%, proving the feasibility and effectiveness of the simulation.  Figure 6 shows the velocity and streamline distributions for the three operating conditions on the X = 0 plane. Figure 7 shows the liquid mass concentration distribution on the X = 0 plane. In the OST, the flue gas enters the tower and flows to the left (the negative direction of the Y axis) and upward (the positive direction of the Z axis) at a relatively high velocity near the inlet. The flue gas stream can be divided into two types according to its flow path, one is the stream S OST,A with a short path in the liquid distribution area, and the other is the flow S OST,B with a long path. Obviously, stream S OST,B has better contact with the liquid. However, the running resistance of S OST,B is larger, making the flue gas flow of stream S OST,A stronger than S OST,B . After the flue gas flows into the liquid distribution area, the flue gas with a high velocity is subject to greater resistance, while that of the flue gas with a low velocity is just the opposite. This is a rectifier phenomenon between gas and liquid phases. Even if there is rectification phenomenon, the flue gas velocity distribution tends to be obviously uniform when the flue gas reaches a height of more than 5 m. In DST, the flue gas passes through the diversion of the first deflector to form two streams, one stream (S DST,A ) flow upward, and the other forms two streams (S DST,B and S DST,C ) by the second deflector. Streams S DST, B and S DST, C have better contact with the liquid and are stronger than S DST,A . In RBST, the flue gas flow is similar to OST, and the component of the flow velocity on the Y axis is larger, which makes the flue gas flow in the negative direction (left) of the Y axis toward the tower. Thus, the flue gas flow of stream S RBST,B is stronger than stream S OST,B .

Contact Condition of Gas-Liquid
In the three working conditions, the spray liquid near the flue gas inlet is affected by the movement of the flue gas and moves to the left, causing the liquid aggregation and high concentration liquid interface formation. And at the same time, an area with zero liquid concentration is formed near the inlet, namely the "Liquid Void Area", causing uneven distribution of liquid. The deflectors cause the liquid to be blocked and concentrated above the deflectors. As a result, two "Liquid Void Areas" are formed below deflectors. In the OST, the gas velocity is high and the liquid concentration is low in the inlet area. The liquid is concentrated in the left side of the tower and almost no gas flows through, resulting in poor gas-liquid contact conditions. However, for streams S DST,B and S DST,C in DST as well as stream S RBST,B in RBST, the velocity component of flue gas in the Y axis direction is relatively high, so the flue gas can flow smoothly to the left side of the tower, thus improving the contact conditions between the two phases, which is the gas-liquid contact intensification effect.  Figure 8 shows the distribution of flue gas velocity and liquid mass concentration on the curve of height Z = 3 m on the plane X = 0. In OST, the liquid mass concentration is evenly distributed at about 4 kg/m 3 . However, within the range of Y = 4-6 m, the velocity of flue gas is higher than 6 m/s and the maximum reaches 8.8 m/s, forming a wide range of "flue gas channel", resulting in a short gas-liquid contact time, and insufficient heat and mass transfer. In DST, the existence of the diversion of the deflectors makes the occurrence of two peaks in the flue gas velocity curve, and the maximum velocity is up to 6.3 m/s. At the position of the left peak, the liquid mass concentration distribution is also at the peak, and the gas-liquid contact has been intensified. At the same time, at the position of the right peak, the flue gas velocity is far less than that of OST, and the liquid mass concentration is also around 4 kg/m 3 . Therefore, the gas-liquid contact is also strengthened. In RBST, the maximum peak velocity of flue gas is 8.4 m/s, which is lower than OST. Flue gas velocity and liquid mass concentration fluctuate, obviously. High-speed flue gas and high mass concentration liquid do not continuously gather, which avoids the formation of a wide range of "flue gas channel", which also strengthens the gas-liquid contact. Figure 9 displays the average temperature distribution curve of flue gas at different height Z of the desulfurization spray tower. Figure 10 displays the distribution of flue gas temperature at different planes. In OST and RBST, the average temperature of flue gas reaches its maximum at Z = 0 (inlet center level height). The maximum average temperature of RBST is greater than OST for the reason that the flue gas of RBST is more widely distributed on the plane Z = 0. Then, as the heat transfer process continues, the flue gas temperature gradually decreases. When the flue gas moves upward to Z = 2 m, the average temperature of flue gas in RBST is already less than OST, and the temperature difference between them becomes larger with the increase in height. Due to the gas-liquid contact intensification caused by the rod bank, the heat transfer efficiency between the two phases in RBST is increased. In DST, due to the action of the first deflector, part of the flue gas flows downward for a certain distance, so the maximum average temperature is at the height Z = −2 m. When the flue gas moves towards Z = 1 m, the gas-liquid contact strengthening effect of DST makes the average temperature of DST flue gas lower than OST. Finally, when the flue gas moves to a position above Z = 7 m, the two phases are out of contact; the average temperature of flue reaches a stable state.    Figure 11 is the distribution of flue gas temperature at Z = 8 m plane. In OST, twophase heat transfer is insufficient while there is higher temperature in part of the flue gas. In DST and RBST, the two-phase heat transfer effect is better, which further verifies the promoting effect of gas-liquid contact intensification on heat transfer.  Table 5 shows the temperature difference between inlet and outlet of the three working conditions. The temperature difference between inlet and outlet of DST is 3.3 K, which is higher than that of OST. In RBST, the gas-liquid heat transfer effect is the best, and the temperature difference between inlet and outlet flue gas is 5.3 K higher than that of OST. 4.3. The Mass Transfer of Gas-Liquid Figure 12 displays the concentration distribution of sulfur dioxide. When the flue gas enters the tower, SO 2 reacts quickly with the slurry and its concentration decreases gradually. In OST, Stream S OST,A is still diffused for high concentration of SO 2 due to its poor contact condition with liquid and incomplete reaction. In DST, the distribution of high concentration of SO 2 in the Y axis is more extensive, which is more conducive to the reaction. In RBST, the high concentration of SO 2 is more widely distributed in the Y-axis direction, while the SO 2 concentration drops sharply and the reaction is violent when the flue gas moves to the position of the rod bank. In DST and RBST, although SO 2 is not completely absorbed due to contact intensification, the concentration of escaped SO 2 was significantly lower than that of OST. In Table 6, the desulfurization efficiency under three working conditions is listed. The desulfurization efficiency of DST and RBST increase by 1.8% and 3.6%, respectively, when compared with OST.

Pressure Drop of Tower
The pressure drop in the desulfurization spray towerhas a significant impact on operating costs. Installing deflectors and rod bank in the desulfurization spray tower will cause an obvious effect on flue gas operation. Therefore, the running resistance of the tower must be optimized.
In Figure 13, the pressure changes mainly occurred in two areas. First, the pressure decreases under the spray layer area. Second, pressure mutations occur in the porous media zone. In Figure 14, the pressure distribution curve along the central axis of the tower is shown. The difference of pressure variation in the three working conditions is mainly in the area below the spray levels. Here, the reason for the pressure drop is the change of tower structure, rectifying components (deflectors and rod bank) and resistance from liquid phase. In DST, the flue gas flows from both sides of the deflectors, which causes less resistance. Meanwhile, the deflectors cause the "liquid void areas", which indirectly reduces the resistance from liquid phase. Therefore, overall, the pressure required by the DST inlet is reduced relative to the OST. In RBST, the rod bank has a direct obstruction effect on the flow of flue gas. Meanwhile, its liquid phase distribution is similar to OST, and the resistance from liquid phase does not decrease. Therefore, the pressure required by RBST inlet is increased relative to OST.   Table 7 lists inlet and outlet pressure drop data under three working conditions. The pressure drop of DST is 37 Pa lower than that of OST. In RBST, the rods are distributed across the entire cross section of the tower, which impedes the flow of the flue gas. As a result, the pressure drop is 33 Pa higher than the OST.

Conclusions
In this paper, the Euler-Lagrange method, the standard k-ε turbulence model, the SO 2 absorption model and porous media model based on the two-film theory are applied to simulate the gas-liquid two-phase flow with the consideration of heat and mass transfer between phases for DST, RBST and OST. Comparisons are summarized and the conclusions are as follows: 1.
The experimental data are measured in a wet flue gas desulfurization tower of a 330 MW coal-fired unit; Compared with the simulation data in OST, the temperature difference, pressure drop and desulfurization efficiency is basically the same, which indicates that the numerical method is feasible and effective. 2.
The gas-liquid contact intensification is mainly reflected in two aspects. First, the deflectors and the rod bank force the flue gas to the place where the liquid concentration is high, enhancing the liquid utilization efficiency. Second, the deflectors and the rod bank reduce the peak velocity of the flue gas and ensure the residence time of the flue gas in the liquid distribution area.

3.
In DST, "Liquid Void Areas" are formed below the deflectors, which apparently has a weaken effect on gas-liquid contact. However, the flue gas flow passing under the deflectors will flow to the high concentration distribution area of the liquid, so that the DST as a whole still plays the role of gas-liquid contact strengthening. At the same time, "Liquid Void Areas" will reduce the resistance of flue gas flow. 4.
The gas-liquid contact intensification can enhance the heat and mass transfer effect in the DST and RBST. In RBST, there is no factor to weaken the gas-liquid contact, so the heat and mass transfer effect is obviously better than DST. 5.
In RBST, the resistance of flue gas flow increases, so it is necessary to pay attention to the increase in operation cost when using the rod bank to optimize the flow field.  Informed Consent Statement: Not applicable.
Data Availability Statement: All relevant data presented in the article are stored according to institutional requirements and, as such, are not available online. However, all data used in this manuscript can be made available upon request to the authors.

Conflicts of Interest:
The authors declare no conflict of interest.