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Open AccessFeature PaperReview

Effect of Oxaliplatin on Voltage-Gated Sodium Channels in Peripheral Neuropathic Pain

Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea
Processes 2020, 8(6), 680; https://doi.org/10.3390/pr8060680
Received: 6 May 2020 / Revised: 29 May 2020 / Accepted: 6 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue Cancer Systems Biology and Natural Products)
Oxaliplatin is a chemotherapeutic drug widely used to treat various types of tumors. However, it can induce a serious peripheral neuropathy characterized by cold and mechanical allodynia that can even disrupt the treatment schedule. Since the approval of the agent, many laboratories, including ours, have focused their research on finding a drug or method to decrease this side effect. However, to date no drug that can effectively reduce the pain without causing any adverse events has been developed, and the mechanism of the action of oxaliplatin is not clearly understood. On the dorsal root ganglia (DRG) sensory neurons, oxaliplatin is reported to modify their functions, such as the propagation of the action potential and induction of neuropathic pain. Voltage-gated sodium channels in the DRG neurons are important, as they play a major role in the excitability of the cell by initiating the action potential. Thus, in this small review, eight studies that investigated the effect of oxaliplatin on sodium channels of peripheral neurons have been included. Its effects on the duration of the action potential, peak of the sodium current, voltage–response relationship, inactivation current, and sensitivity to tetrodotoxin (TTX) are discussed. View Full-Text
Keywords: allodynia; oxaliplatin; peripheral neuropathic pain; voltage-gated sodium channel allodynia; oxaliplatin; peripheral neuropathic pain; voltage-gated sodium channel
MDPI and ACS Style

Kim, W. Effect of Oxaliplatin on Voltage-Gated Sodium Channels in Peripheral Neuropathic Pain. Processes 2020, 8, 680.

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