Non-Cardiac Cause of Death in Selected Group Children with Cardiac Pathology: A Retrospective Single Institute Study

Background: Pediatricians and pediatric surgeons often face children with cardiomegaly and dilatative or hypertrophic cardiomyopathies presenting with or without symptoms. Some of these patients have already been diagnosed and received medication, and some present with completely unrelated pathologies. Methods: We performed a 4-year retrospective study on the causes and mechanisms of death of children with cardiac pathology who died outside the cardiology clinic of our hospital by studying the hospital charts and necropsy reports. All children who were in this situation in our hospital were included. Results: Most children in our study group were infants (81.82%), most were boys (81.82%), and in most cases, the cause or mechanism of death was unrelated to their heart condition, whether it had already been diagnosed or not (one case probably died as a result of a malignant ventricular arrhythmia). Additionally, 27.27% of children died as a consequence of bronchopneumonia, the same percentage died as a consequence of an acquired non-pulmonary disease or after surgery, and 18.18% died as a consequence of congenital malformations. Conclusions: Cardiac disease needs to be thoroughly investigated using multiple tools for all children presenting with heart failure symptoms, those with heart murmurs, and children scheduled for surgery of any type. The intensive care specialist and surgeon need to be aware of any heart pathology before non-cardiac surgical interventions.


Introduction
Of all children born worldwide, 0.8-1.2% suffer from congenital cyanotic or noncyanotic heart malformations [1]. Furthermore, acquired heart diseases, such as dilated cardiomyopathy secondary to myocarditis; iron overload; arrhythmia; electrolyte imbalances; autoimmune or endocrinological diseases; nutritional deficiencies, drug exposure, or hypertrophic cardiomyopathy secondary to storage diseases; fatty acid oxidation abnormalities; primary hyperinsulinism or acromegaly; and valvulopathies, are also possible, making heart disease an important source of mortality and morbidity in all pediatric age categories. When other severe conditions, either medical or surgical, overlap, the prognosis is grim, but the cause or mechanism of death is not always related to the heart disease itself.
Our study aimed to identify the noncardiac causes of death of children suffering from cardiomyopathies or cardiomegaly in order to improve the management of these cases. This topic is seldom addressed in the literature; a search for the keywords "noncardiac causes of death dilated cardiomyopathy cardiomegaly" performed on PubMed yielded no significant results, and articles on dilated cardiomyopathy or cardiomegaly focus on cardiac disease evolution and prognosis [2,3].

Materials and Methods
We performed a retrospective study on all children diagnosed with any type of cardiomyopathy or cardiomegaly due to heart malformations who died outside the cardiology clinic (in other clinics) of Saint Mary Emergency Children's Hospital in Iasi, Romania, over a 4-year period (2018)(2019)(2020)(2021). This study has no selection bias, as we included all patients suffering from various conditions who died outside the cardiology clinic in the given timeframe. We examined the files and necropsy reports of these children. Clinical files included reasons for admission; information about the clinical examination of the patient upon admission and daily evolution; hematological and biochemical parameters; imaging results (X-ray, echocardiogram, etc.); and medical, intensive care, and surgical treatment.
The necropsy files included data about the general inspection of the corpse, macroscopic analysis of the internal organs (including assessments of the heart size and type of heart malformation), and, in most cases, microscopic organ analysis (including that of the myocardium).
Informed consent was obtained from all parents or caregivers at the time of admission, and the Saint Mary Children's Emergency Hospital Ethics Committee's approval was obtained for publishing this study (19077/2 July 2021).
We identified 11 children suffering from heart conditions during a 4-year period who died in non-cardiology clinics of our hospital. Some children died on the same day they were admitted to our hospital, some had been suffering from cardiomyopathies or heart malformations leading to cardiomegaly for some time, and some were first diagnosed during the admission in which they passed away; for others, the cardiomegaly or cardiomyopathy diagnose has been established after death.
Of the 11 cases analyzed, 2 were female and 9 were male (see Table 1).

Results
Patient number 1 was transferred from a local maternity ward with the suspicion of duodenal stenosis. The child was prematurely born at home at the gestational age of 32 weeks and had a birth weight of 1500 g. He was admitted into a newborn intensive Children 2022, 9, 335 3 of 14 care facility 2 h after birth. Upon admission, signs of respiratory failure were present, and there was a III/VI systolic murmur audible over the precordial area. Echocardiography initially showed the presence of a large interatrial septal defect, a ventricular septal defect, and a patent ductus arteriosus. The presence of a moderate form of coarctation of the aorta was later diagnosed. Two months after birth, the cardiologist diagnosed global cardiac hypertrophy (concentric left ventricle hypertrophy, right atrial and right ventricular hypertrophy), and one month later, pulmonary hypertension was also present. The corpus callosum agenesis was diagnosed on the second day of life. A cardiac surgery center was contacted, but surgery was not performed because the case did not represent a cardiac surgery emergency.
The evolution of the case was unfavorable. The patient received oxygen beginning on the first day of life and was intubated at the age of 2 months. Diuretic therapy for heart failure was started on day 34. A few days later, several episodes of vomiting appeared; as they became more and more frequent, a barium meal raised the suspicion of duodenal stenosis, and the patient was admitted to the general surgery ward of our hospital. He needed to be resuscitated as soon as he arrived, and the clinical status did not improve enough during the hospitalization to allow surgery to be performed.
Patient number 2 was born in the 37th week of gestation and had a birth weight of 2550 g and an APGAR score of 4 at 1 min. The mother had previously given birth to another boy suffering from spinal amyotrophy who died 3 months after birth. The child needed to be intubated from birth because of inefficient spontaneous respiration. The evolution was unfavorable, with bronchoplegia, generalized hypotonia, ascension of the right hemidiaphragms, absence of osteotendinous, and archaic reflexes. Echocardiography showed a large patent foramen ovale; septal hypertrophic cardiomyopathy; and dilatation of the right atrium, right ventricle, and pulmonary artery. The child did not undergo surgery, but a center specializing in treating spinal amyotrophy was contacted for transfer.
Patient number 3 was known to suffer from obstructive hypertrophic cardiomyopathy, moderate aortic stenosis, ventricular septal defect, Wolff-Parkinson-White preexcitation syndrome, partial corpus callosum agenesis bilateral hip dysplasia, and posterior palatoschisis. He was admitted to the general surgery ward of our hospital for surgical treatment of umbilical and inguinal hernias. The procedure was performed with no incidents, but the patient died 2 h after surgery.
Patient number 4 was suffering from tetralogy of Fallot with severe pulmonary stenosis, severe tricuspid regurgitation, patent ductus arteriosus, and class III NYHA heart failure and was receiving cardiological medication. At the time of the cardiorespiratory arrest, he was admitted to an external ward of our hospital. Resuscitation was initiated and later continued by the ambulance personnel, but the outcome was unfavorable. The necropsy established the diagnosis of transposition of the great arteries, a ventricular septal defect, patent ductus arteriosus, and minimal aortic stenosis.
Patient number 5 had two cases of malignant hematological diseases in his family. At the age of 6 weeks, the parents presented to the hospital because the child was agitated and refused feedings. The hemoleucogram showed pancytopenia, and the child was transferred to our hospital, where the diagnosis of hemophagocytic lymphohistiocytosis was established on the basis of the presence of hepatosplenomegaly, severely increased ferritin, hepatic dysfunction, severe hypofibrinogenemia, hypertriglyceridemia, hypoproteinemia, hyponatremia, jaundice, edema, skin rash, and exclusion of other hematological malignancies by marrow immunophenotyping. Echocardiography showed a small patent foramen ovale, and the necropsy also diagnosed hypertrophic cardiomyopathy.
Patient number 6 was admitted by transfer from a smaller hospital, where he had been hospitalized for one day for signs of respiratory distress, ineffective cough, agitation, and vomiting. This was a child also suffering from cow milk protein intolerance and gastroesophageal reflux. Upon admission to our hospital, a second-degree systolic murmur was noticed, and the cardiology consult established the diagnosis of dilated cardiomyopathy and class IV Ross heart failure. In this case, the dilated cardiomyopathy was probably secondary to a viral myocarditis episode, as the mother noticed progressive effort dyspnea following a diarrhea episode. The chest X-ray was suggestive of bronchopneumonia. The child died despite antibiotic, supportive, and positive inotropic treatment. Patient number 7 was suffering from chronic infantile encephalopathy, spastic tetraparesis, hydrocephaly, and atrial septal defect. He developed signs and symptoms of an inferior respiratory infection whose evolution was unfavorable. The anatomopathological exam also discovered the presence of dilated cardiomyopathy.
Patient number 8 was diagnosed 10 months earlier with third-degree posterior fossa ependymoma involving the cerebral trunk, cerebellum, and fourth ventricle and was a ventriculoperitoneal and tracheostomy carrier with no neurosurgical indication. During hospitalization, he became febrile; purulent secretion was drained from the tracheostomy; the oxygen saturation dropped despite oxygen, antibiotic, and supportive treatment; fixed miosis appeared; and irreversible cardiorespiratory arrest occurred. The necropsy described the presence of cardiomegaly.
Patient number 9 was suffering from Prader-Willy syndrome, epilepsy, severe obesity, severe neuromotor retardation, had a seeing and hearing impairment, and had been hospitalized for 6 days before admission to a smaller hospital, where he received treatment for bronchopneumonia. He was oxygen-dependent during the entire hospitalization at our hospital, despite intensive antibiotic, pathogenic, and supportive treatment. The necropsy discovered cardiomegaly, aortic and pulmonary artery enlargement, and a vascular abnormality-common origin of the brachiocephalic trunk and primitive left carotid artery.
Patient number 10 was born in the 36th week of gestation and was diagnosed postpartum with giant omphalocele accompanied by intestinal malrotation and occlusion. She was admitted to our hospital for surgical management. The first part of the surgery proceeded smoothly; the liver, spleen, and part of the intestine were integrated into the peritoneal cavity, and 10 days later, the rest of the intestine was integrated, and the abdominal wall was sutured. Soon after surgery, the patient developed edema, thrombocytopenia, and cardiocirculatory arrest. Necropsy findings included cardiomegaly.
The last patient was born during the 30th week of gestation and diagnosed after birth with spina bifida. She received neurosurgical treatment for this condition, but the postoperative evolution was unfavorable. Because of the urgency of the neurosurgical intervention, this child was not examined by a cardiologist before intervention. The necropsy showed that she was suffering from truncus arteriosus and a membranous ventricular septal defect causing predominant right-sided heart enlargement.
The average hospitalization duration was 12.09 days and ranged from 1 day to 31 days. In two cases, the cardiac diagnosis was established via echocardiography and did not coincide with necropsy findings.
All but two children were newborns or infants at the time of death. Two out of eleven children were diagnosed with a heart condition before their last hospitalization, and they were receiving cardiac medication. In three cases, the heart condition was first diagnosed during necropsy. Three children underwent surgery for non-cardiac conditions (umbilical and inguinal hernia, giant omphalocele, intestinal malrotation, and occlusion and spina bifida with myelomeningocele). The deaths of these patients occurred in the postoperative period, and the mechanism of death was probably related to periprocedural events or anesthetic procedures.
Four out of eleven children died as a consequence of their main disease: corpus callosum agenesia, hemophagocytic lymphohistiocytosis, spinal amyotrophy, or brain tumor. Additionally, 27.27% of children died as a consequence of bronchopneumonia, the same percentage died as a consequence of an acquired non-pulmonary disease or after surgery, and 18.18% died as a consequence of congenital malformations. One child died as a result of a probable malignant ventricular arrhythmia (sudden death).
The echocardiographic examination was performed using a General Electric machine. The images below were obtained from a dilated cardiomyopathy patient.
Marked ventricular remodeling caused the sphericity index to become abnormal ( Figure 1). Low cardiac output was suggested by decreased amplitude and duration of mitral and aortic valve opening. Mitral ( Figure 2) and tricuspid ( Figure 3) regurgitations ranging from mild to severe may have existed.
Four out of eleven children died as a consequence of their main disease: corpus callosum agenesia, hemophagocytic lymphohistiocytosis, spinal amyotrophy, or brain tumor. Additionally, 27.27% of children died as a consequence of bronchopneumonia, the same percentage died as a consequence of an acquired non-pulmonary disease or after surgery, and 18.18% died as a consequence of congenital malformations. One child died as a result of a probable malignant ventricular arrhythmia (sudden death).
The echocardiographic examination was performed using a General Electric machine. The images below were obtained from a dilated cardiomyopathy patient.
Marked ventricular remodeling caused the sphericity index to become abnormal ( Figure 1). Low cardiac output was suggested by decreased amplitude and duration of mitral and aortic valve opening. Mitral ( Figure 2) and tricuspid ( Figure 3) regurgitations ranging from mild to severe may have existed.   The pediatric cardiologist should remember to check for the presence of atrial, appendage or ventricular thrombi, or spontaneous contrast. The likelihood of discovering such masses is proportional to the severity of the systolic dysfunction. In addition, the existence of pulmonary hypertension should be checked upon the first presentation and later during the evolution of the disease.
Necropsy included macroscopic and microscopic examination of the heart (Figure 4). Myocarditis was found in several cases was associated with bronchopneumonia.  The pediatric cardiologist should remember to check for the presence of atrial, appendage or ventricular thrombi, or spontaneous contrast. The likelihood of discovering such masses is proportional to the severity of the systolic dysfunction. In addition, the existence of pulmonary hypertension should be checked upon the first presentation and later during the evolution of the disease.
Necropsy included macroscopic and microscopic examination of the heart (Figure 4). Myocarditis was found in several cases was associated with bronchopneumonia. such masses is proportional to the severity of the systolic dysfunction. In addition, the existence of pulmonary hypertension should be checked upon the first presentation and later during the evolution of the disease.
Necropsy included macroscopic and microscopic examination of the heart (Figure 4). Myocarditis was found in several cases was associated with bronchopneumonia. The pediatric cardiologist should remember to check for the presence of atrial, appendage or ventricular thrombi, or spontaneous contrast. The likelihood of discovering such masses is proportional to the severity of the systolic dysfunction. In addition, the existence of pulmonary hypertension should be checked upon the first presentation and later during the evolution of the disease.
Necropsy included macroscopic and microscopic examination of the heart (Figure 4) Myocarditis was found in several cases was associated with bronchopneumonia.

Discussion
A total of 74,053 children were treated in the hospital during the 4 years we studied (2018-2021). There were 358 deaths reported during this period in our hospital (0.48%) ( Table 2). The patients in our study group suffered either from congenital heart malformations leading to cardiomegaly or cardiac hypertrophy or from primary cardiomyopathiesdilated or hypertrophic. However, their deaths were not caused by their heart conditions alone in all but one case, who probably developed a malignant ventricular arrhythmia, which manifested as sudden death, in a patient with transposition of the great arteries and a patent ductus arteriosus.
Severe inferior respiratory disease, such as bronchopneumonia, seems to have a worse prognosis for infants suffering from cardiac malformations with pulmonary overcirculation [4], despite maximal intensive care treatment directed at the heart failure and respiratory disease itself. The patients diagnosed with bronchopneumonia in our group, however, did not have left-right shunt malformations. Two developed cardiac chamber dilatations as a consequence of dilatative cardiomyopathy, and one suffered from hypertrophic cardiomyopathy.
None of the children were cyanotic during hospitalization. Children directly admitted to a surgical ward did not always have a cardiology consult before their operation, and neither did one child who was admitted to a general pediatrics clinic. All children admitted to the intensive care unit, however, did undergo a cardiology consultation. A systolic murmur was only described upon admission for three children, but not for the one suffering from one of the most severe malformations-truncus arteriosus.
Our study group was mainly composed of infants and male children. This is consistent with other group findings, as both hypertrophic [5] and dilated [6] cardiomyopathies were found to have a higher prevalence in males.

Definitions
Dilated cardiomyopathy is defined by the presence of left ventricular or biventricular dilatation and systolic dysfunction (accompanied by diastolic dysfunction or not) in the absence of other causes of systolic impairment, such as sepsis, abnormal loading (valvular diseases or hypertension), and coronary artery disease. In children, ventricular dilatation should be diagnosed in the presence of an end-diastolic volume or diameter larger than +2 standard deviations corrected for body surface area, age, and gender [7,8]. A Z score above 2 applied to left ventricular end-diastolic or end-systolic volumes or diameters is relevant for the diagnosis [9].
Hypertrophic cardiomyopathy is defined as an increase in the heart wall thickness above the normal values for age, height, and weight that cannot be explained only by abnormal ventricular load. In children, this condition has an important genetic predisposition [10] involving the actin, myosin, tropomyosin, and titin genes [11].

Incidence
Dilated cardiomyopathy incidence in the United States of America seems to be 1.13 cases in 100,000 children [12], similar to what one study [13] found in Australia-1.24 in 100.000-and the findings of another study [14] in Finland-0.34 cases per 100,000 children per year. One study conducted in New England and the Central Southwest reported an annual incidence of 1.13 per 100,000 infants and children [12]. Another study conducted in Egypt and Kuwait reported an overall rate of dilated cardiomyopathy in childhood of 0.07 cases/100,000/year [15].
The peak incidence of the disease is in the first two years of life [16], and this pathology represents the most frequent indication for heart transplantation in children.
One study found that 42% of all childhood cardiomyopathies are of the hypertrophic type, and the incidence of the disease is 0.47 in 100.00 children [12].
Anthracyclines (daunorubicin or doxorubicin) are well-known to induce dose-dependent cardiac toxicity, manifesting as congestive heart failure during or immediately after treatment is completed. Children receiving more than 300 g/m 2 of anthracyclines were found to have increased left ventricular afterload, sometimes accompanied by contractility impairment [19]. Cardiotoxicity was more severe in females, in children receiving high doses of daunorubicin or doxorubicin, and in those also receiving cyclophosphamide or spinal or mediastinal irradiation for acute leukemia or lymphoma [20].
Not only infectious causes are incriminated in the development of dilated cardiomyopathy in children. Most children affected by muscular dystrophy eventually develop low cardiac output symptoms as a sign of heart dilatation and systolic impairment, ultimately causing death. Duchene and Becker muscular dystrophies, both caused by mutations in the dystrophin gene, are characterized by abnormal cardiomyocyte function in terms of ion channel stretch response. Stretch causes increased cardiomyocyte calcium influx, which activates proteases that degrade troponin I [39]. Chronic calcium overload causes cardiomyocyte apoptosis [40]. Although initially, children with Friedreich's ataxia have echocardiography findings of hypertrophic cardiomyopathy, toward the end of their lives, they also present with features of dilated cardiomyopathy. In this stage, they develop life-threatening arrhythmia and abrupt heart function decline [41]. Types I, II, and VI mucopolysaccharidoses are sometimes associated with dilated cardiomyopathy, although valve disease and not chamber dilatation is a more specific association [42]. More typical dilated cardiomyopathy echocardiography findings are found in glycogen storage disease children (Danon disease, phosphorylase kinase deficiency, Brancher enzyme deficiency, and Glycogenin-1 deficiency) [43].
Dilated cardiomyopathy can be caused by several endocrine diseases, such as pheochromocytoma [44], hypothyroidism [45], hyperthyroidism [46], and hypoparathyroidism [47]. More specific etiologies for dilated cardiomyopathy in newborns, infants, and children refer to lysosomal diseases, glycogen storage disorders, mitochondrial disorders, fatty acid oxidation disorders, and organic acidurias. Fatty acid oxidation disorders should be suspected in children with cardiomyopathy who develop recurrent episodes of nonketotic hypoglycemia. A hypotonic child with dilated cardiomyopathy should be suspected to have Pompe disease, while all storage diseases should be investigated in a child with dilated cardiomyopathy and hepatomegaly [48].
Ischemic dilated cardiomyopathy in children is rare and is due to ALCAPA syndrome (Anomalous Left Coronary Artery Origin from the Pulmonary Artery) [49]. Between 80 and 85% of patients fail to develop adequate myocardial collateral supply and present with signs and symptoms consistent with heart failure.
The etiology of hypertrophic cardiomyopathy includes maternal diabetes; child primary hyperinsulinism or acromegaly; Pompe, Danon, or Cori-Forbes diseases; Noonan and Costello syndromes; mucopolysaccharidosis; and several fatty acid oxidation disorders [55].

Clinical Picture
Ventricular dilatation and systolic dysfunction are often unapparent in the preclinical phase of dilated cardiomyopathy [56], or the patient may experience palpitations, explained by arrhythmias or conduction defects [4].
The symptoms that older children experience in the initial phases are nonspecific and include fatigability, effort-related dyspnea, cough, palpitations, thoracic pain, presyncope, and syncope [57]. Infants and toddlers may be brought for examination because Children 2022, 9, 335 9 of 14 of symptoms such as irritability, poor feeding, excessive sweating during alimentation, and failure to thrive, or symptoms of heart failure-related peripheral organ dysfunction, such as oliguria. Other possible symptoms include hemoptysis, abdominal pain, and wheezing [58]. Wheezing is explained by terminal bronchiolar extrinsic compression by excess interstitial fluid in the decompensated heart failure phase.
Clinical examination reveals signs of left and right ventricular systolic dysfunction. Diminished anterograde left ventricular flow leads to cool extremities, weak peripheral pulses, and hypotension. Right ventricular failure manifests as peripheral edema, hepatomegaly, stasis crepitations, increased jugular pressure, or hepato-jugular reflux. Gallop rhythm, defined by the presence of the third or fourth heart sound, may also be present, as may murmurs of tricuspid or mitral regurgitations. These murmurs are explained not by valvular disease but by heart chamber dilatation, which eventually involves all four cavities, leading to annular dilatation. Murmurs may go unnoticed if the patient is in shock or acute heart failure because severe contractility impairment causes less blood to flow back to the atria.
Tachycardia is not only another important clinical sign but also a central compensatory mechanism. In most of these patients, the other classical central compensatory mechanism, the increase of the ventricular contraction force, is unavailable.
When ALPACA syndrome causes myocardial dysfunction, children may present with typical angina or a continuous murmur on the left parasternal border caused by blood flow through collateral vessels [49].
In hypertrophic cardiomyopathy, children may present with symptoms of congestive heart failure, angina, diminished anterograde outflow symptoms such as dizziness, presyncope or syncope, and sudden death caused by ventricular fibrillation. Orthopnea and paroxysmal nocturnal dyspnea are caused by diastolic dysfunction and pulmonary venous congestion. Whenever the clinician notices a systolic ejection murmur that has a crescendo-decrescendo character, an echocardiogram is indicated. The murmur described above may be accompanied by another one-one of mitral regurgitation, best heard at the apex or in the axilla, or one of aortic regurgitation, which is diastolic.

Echocardiography
Echocardiography is a reliable diagnostic tool for both dilated and hypertrophic cardiomyopathy, as well as most heart malformations.
Basic measurements in suspected cases of dilated cardiomyopathy include wall thickness and chamber dimensions (including the end-systolic and end-diastolic diameters of the left ventricle) and chamber volumes (including the end-systolic and end-diastolic volumes of the left ventricle). Systolic function is estimated through the ejection fraction and shortening fraction. The ejection fraction can be visually estimated-a method that is no longer recommended because of interobserver variability-or estimated using the Teicholz, one-plane, modified one-plane, and biplane Simpson methods. Mitral and tricuspid annular plane systolic excursions also provide information about longitudinal shortening. The pressure increase rate inside the left ventricle can be estimated on the basis of a mitral regurgitation envelope-if it exists-using the dp/dt ratio. Global ventricular function, both systolic and diastolic, can be evaluated using the Tei index. It is not dependent on age, heart rate, or left ventricle geometry, but it is dependent on afterload [59].
Regional systolic kinetics is evaluated using the Wall Motion Score Index or newer methods, such as harmonic imaging, acoustic quantification, color kinesis, contrast echography, tissue Doppler imaging, and myocardial strain/strain rate [60].
Diastolic dysfunction in dilated cardiomyopathy is also possible. Ways to estimate the severity of the dysfunction include the diastolic trans-mitral flow (E/A >2, E wave deceleration time <150 ms, isovolumetric relaxation time <60 ms), Doppler flow in the pulmonary veins (the S wave diminishes and the AR wave becomes larger), and tissue Doppler imaging [60].
In hypertrophic cardiomyopathy, the echocardiogram must focus on correct wall thickness measurement and left ventricular outflow tract velocity measurement. This last measurement, along with the systolic anterior motion of the anterior mitral valve leaflet, differentiates between the obstructive and nonobstructive forms of the disease. Furthermore, left ventricular diastolic patterns must be carefully interrogated in order to diagnose diastolic dysfunction.

Histological Findings
In children, it is rarely indicated to obtain a biopsy specimen via endomyocardial biopsy (unless the clinician suspects cardiac involvement in a systemic disease). Biopsy on necropsy findings of dilated cardiomyopathy patients includes myocyte atrophy [61], myocyte vacuolar degeneration [62], myositis [62], nuclear pleomorphism [63], focal fat or inflammatory infiltration, and fibrosis [64].
Aspects encountered in hypertrophic cardiomyopathy include disorganization of the myofibrillar architecture, visible fibrosis, and abnormal intramural coronary arteries, explaining chest pain in children.

Treatment
Children with dilated cardiomyopathy should be encouraged to remain active whenever possible, as physical activity improves muscle and mental tonus and life quality. Diet should take into consideration the hypercatabolic state associated with this condition, as well as the fact that some children may be too sick for oral feeding. In this group, nasogastric tube or intravenous feeding is necessary.
Whenever the cause of the disease is known, etiological treatment should be attempted whenever possible. Symptomatic treatment addresses the heart failure manifestation and consists of angiotensin-converting enzyme inhibitors (which have been shown to reduce mortality in adults), diuretics and beta-blockers (under close supervision, so that they do not worsen symptoms), or even ivabradine [64]. Intracardiac thrombi or spontaneous contrast dictate the need for chronic anticoagulation [65]. Digoxin, the classical oral positive inotropic agent, is currently seen as second-line therapy [65]. Intractable cardiac failure requires left ventricular or biventricular assist devices as a bridge to heart transplantation.
Hypertrophic cardiomyopathy patients should receive medication in order to reduce the left ventricle outflow gradient, such as beta-blockers. Calcium channel blockers, amiodarone, and disopyramide are effectively used in adults to treat and prevent ventricular arrhythmias [11]. Inotropic drugs, nitrates, and sympathomimetic amines should be avoided whenever possible. Some children, those who have suffered from ventricular fibrillation, ventricular tachycardia, or cardiac arrest, should be considered for implantable cardioverter defibrillators.
Heart malformations must be operated on before they cause chamber dilatation or pulmonary hypertension. In the meantime, children may receive heart failure treatment.

Outcomes
The prognosis of dilated cardiomyopathy seems to be worse in children than adults. The disease seems to progress faster in children, despite the fact that heart failure symptoms had been observed for a shorter period of time before diagnosis. Furthermore, children develop life-threatening ventricular arrhythmias more often than their adult peers [66] and require heart transplantation more often [12]. The prognosis is worse in those presenting with heart failure symptoms after the age of 1 year old, in those with severe dilatation and poor systolic function [67], and in those with idiopathic dilated cardiomyopathy [68]. Prognosis is better in patients with myocarditis-related dilated cardiomyopathy [69]. In some countries, heart transplantation has become more accessible over the past years. Multidisciplinary care improved patient prognosis recently [68]. One study [67,70] reported 81% of free-from-death or transplantation children at 5 years if the cause of the dilated cardiomyopathy was myocarditis, while the same parameter dropped to 62% in idiopathic or familial disease. Family history of cardiac disease and the need for inotropic support during hospitalization and other associated abnormalities were also identified as poor prognostic factors by others [71][72][73].
Heart transplantation is recommended for children with hypertrophic cardiomyopathy with restrictive physiology who do not respond to other interventions. Survival is etiologyand age-specific in these patients [74].

Conclusions
Cardiac disease needs to be thoroughly investigated using multiple tools in all children presenting with heart failure symptoms, in those with heart murmurs, and in children scheduled for surgery of any type. Cyanosis does not need to be present, since multiple potentially life-threatening heart conditions, such as dilatative or hypertrophic cardiomyopathy, are not accompanied by this symptom. A complicated medical history or the presence of abnormal findings on clinical examination should point the treating physician toward recommending a pediatric cardiologist consultation. In these instances, cardiological diagnosis is a must. Additionally, every newborn should benefit from a cardiac ultrasound and electrocardiography to rule out cardiac pathology, especially if a surgical intervention is planned for them in the future. The intensive care specialist and surgeon need to be aware of any heart pathology before non-cardiac surgical interventions; therefore, a preoperative cardiological consult may prove beneficial even if there are no obvious signs of cardiac disease.