Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Łuczak, J.; Bagłaj, M. Ovarian teratoma in children: A plea for collaborative clinical study. J. Ovarian Res. 2018, 11, 75. [Google Scholar] [CrossRef] [PubMed]
- Lindfors, O. Primary ovarian neoplasms in infants and children. A study of 81 cases diagnosed in Finland and Sweden. Ann. Chir. Gynaecol. Fenn. Suppl. 1971, 177, 1–66. [Google Scholar] [PubMed]
- Martelli, H.; Patte, C. [Gonadal tumours in children]. Arch. Pediatr. 2003, 10, 246–250. [Google Scholar] [CrossRef]
- Anton-Păduraru, D.-T.; Miron, I.C.; Lupu, V.V.; Lupu, A.; Hanganu, E. Ovarian teratoma in a teenager causing ureterohydronephrosis: Case report and literature review. Medicine 2021, 100, e26472. [Google Scholar] [CrossRef] [PubMed]
- Heo, S.H.; Kim, J.W.; Shin, S.S.; Jeong, S.I.; Lim, H.S.; Choi, Y.D.; Lee, K.H.; Kang, W.D.; Jeong, Y.Y.; Kang, H.K. Review of ovarian tumors in children and adolescents: Radiologic-pathologic correlation. Radiogr. Rev. Publ. Radiol. Soc. N. Am. Inc 2014, 34, 2039–2055. [Google Scholar] [CrossRef]
- Harms, D.; Zahn, S.; Göbel, U.; Schneider, D.T. Pathology and molecular biology of teratomas in childhood and adolescence. Klin. Padiatr. 2006, 218, 296–302. [Google Scholar] [CrossRef]
- Outwater, E.K.; Siegelman, E.S.; Hunt, J.L. Ovarian teratomas: Tumor types and imaging characteristics. Radiogr. Rev. Publ. Radiol. Soc. N. Am. Inc 2001, 21, 475–490. [Google Scholar] [CrossRef]
- Oosterhuis, J.W.; Looijenga, L.H.; van Echten, J.; de Jong, B. Chromosomal constitution and developmental potential of human germ cell tumors and teratomas. Cancer Genet. Cytogenet. 1997, 95, 96–102. [Google Scholar] [CrossRef]
- Heifetz, S.A.; Cushing, B.; Giller, R.; Shuster, J.J.; Stolar, C.J.; Vinocur, C.D.; Hawkins, E.P. Immature teratomas in children: Pathologic considerations: A report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am. J. Surg. Pathol. 1998, 22, 1115–1124. [Google Scholar] [CrossRef]
- Saida, T.; Mori, K.; Masumoto, T.; Hoshiai, S.; Ishiguro, T.; Sakai, M.; Hara, T.; Ochi, H.; Satoh, T.; Minami, M. Ovarian and non-ovarian teratomas: A wide spectrum of features. Jpn. J. Radiol. 2021, 39, 143–158. [Google Scholar] [CrossRef]
- Al Jama, F.E.; Al Ghamdi, A.A.; Gasim, T.; Al Dakhiel, S.A.; Rahman, J.; Rahman, M.S. Ovarian tumors in children and adolescents--a clinical study of 52 patients in a university hospital. J. Pediatr. Adolesc. Gynecol. 2011, 24, 25–28. [Google Scholar] [CrossRef] [PubMed]
- Sarnacki, S.; Brisse, H. Surgery of ovarian tumors in children. Horm. Res. Paediatr. 2011, 75, 220–224. [Google Scholar] [CrossRef] [PubMed]
- Spinelli, C.; Pucci, V.; Strambi, S.; Piccolo, R.L.; Martin, A.; Messineo, A. Treatment of Ovarian Lesions in Children and Adolescents: A Retrospective Study of 130 Cases. Pediatr. Hematol. Oncol. 2015, 32, 199–206. [Google Scholar] [CrossRef]
- Elgendy, A.; Lakshminarayanan, B.; Elrouby, A.; Mostafa, M.; Salem, M.A.; Turner, K.; Khairi, A.; Squire, R.; Shehata, S.M.K.; Shehata, S.; et al. Management of pediatric benign ovarian tumors in England and Egypt: A comparative study. Afr. J. Paediatr. Surg. 2020, 17, 33–38. [Google Scholar] [CrossRef] [PubMed]
- Michelotti, B.; Segura, B.J.; Sau, I.; Perez-Bertolez, S.; Prince, J.M.; Kane, T.D. Surgical Management of Ovarian Disease in Infants, Children, and Adolescents: A 15-Year Review. J. Laparoendosc. Adv. Surg. Tech. 2010, 20, 261–264. [Google Scholar] [CrossRef]
- Özcan, R.; Kuruoğlu, S.; Dervişoğlu, S.; Eliçevik, M.; Emir, H.; Büyükünal, C. Ovary-sparing surgery for teratomas in children. Pediatr. Surg. Int. 2013, 29, 233–237. [Google Scholar] [CrossRef]
- Park, J.-Y.; Kim, D.-Y.; Suh, D.-S.; Kim, J.-H.; Kim, Y.-M.; Kim, Y.-T.; Nam, J.N. Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors. Gynecol. Oncol. 2015, 137, 418–422. [Google Scholar] [CrossRef] [PubMed]
- Braungart, S.; Craigie, R.J.; Farrelly, P.; Losty, P.D. Ovarian tumors in children: How common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study. J. Pediatr. Surg. 2020, 55, 2026–2029. [Google Scholar] [CrossRef]
- Terenziani, M.; D’Angelo, P.; Inserra, A.; Boldrini, R.; Bisogno, G.; Babbo, G.L.; Conte, M.; Indna, P.D.; De Pasquale, M.D.; Indolfit, P.; et al. Mature and immature teratoma: A report from the second Italian pediatric study. Pediatr. Blood Cancer 2015, 62, 1202–1208. [Google Scholar] [CrossRef]
- Zhang, M.; Jiang, W.; Li, G.; Xu, C. Ovarian Masses in Children and Adolescents—An Analysis of 521 Clinical Cases. J. Pediatr. Adolesc. Gynecol. 2014, 27, e73–e77. [Google Scholar] [CrossRef]
- Oue, T.; Uehara, S.; Sasaki, T.; Nose, S.; Saka, R.; Yamanaka, H.; Ueno, T.; Tazuke, Y.; Okuyama, H. Treatment and ovarian preservation in children with ovarian tumors. J. Pediatr. Surg. 2015, 50, 2116–2118. [Google Scholar] [CrossRef] [PubMed]
- Andrés, M.M.; Costa, E.; Cañete, A.; Moreno, L.; Castel, V. Solid ovarian tumours in childhood: A 35-year review in a single institution. Clin. Transl. Oncol. 2010, 12, 287–291. [Google Scholar] [CrossRef] [PubMed]
- Chabaud-Williamson, M.; Netchine, I.; Fasola, S.; Larroquet, M.; Lenoir, M.; Patte, C.; Bénifla, J.; Coulomb-L’Herminé, A.; Grapin, C.; Audry, G.; et al. Ovarian-sparing surgery for ovarian teratoma in children. Pediatr. Blood Cancer 2011, 57, 429–434. [Google Scholar] [CrossRef]
- Pashankar, F.; Hale, J.P.; Dang, H.; Krailo, M.; Brady, W.E.; Rodriguez-Galindo, C.; Nicholson, J.C.; Murray, M.J.; Bilmire, D.F.; Stoneham, S.; et al. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer 2016, 122, 230–237. [Google Scholar] [CrossRef] [PubMed]
- Takayasu, H.; Masumoto, K.; Tanaka, N.; Aiyoshi, T.; Sasaki, T.; Ono, K.; Chiba, F.; Urita, Y.; Shinkai, T. A clinical review of ovarian tumors in children and adolescents. Pediatr. Surg. Int. 2020, 36, 701–709. [Google Scholar] [CrossRef]
- Oltmann, S.C.; Garcia, N.; Barber, R.; Huang, R.; Hicks, B.; Fischer, A. Can we preoperatively risk stratify ovarian masses for malignancy? J. Pediatr. Surg. 2010, 45, 130–134. [Google Scholar] [CrossRef]
- Terzic, M.; Rapisarda, A.M.C.; Corte, D.L.; Manchanda, R.; Aimagambetova, G.; Norton, M.; Garzon, S.; Riemma, G.; King, C.R.; Chiofalo, B.; et al. Diagnostic work-up in paediatric and adolescent patients with adnexal masses: An evidence-based approach. J. Obstet. Gynaecol. 2021, 41, 503–515. [Google Scholar] [CrossRef]
- Ghosh, A.; Ghartimagar, D.; Thapa, S.; Sathian, B.; Narasimhan, R.; Talwar, O.P. Ovarian Tumors: Pattern of Histomorphological Types-A 10 Years Study in a Tertiary Referral Center and Review of Literature. Kathmandu Univ. Med. J. 2016, 14, 153–158. [Google Scholar]
- Renaud, E.J.; Sømme, S.; Islam, S.; Cameron, D.B.; Gates, R.L.; Williams, R.F.; Jancelewicz, T.; Oyetunji, T.A.; Grabowski, J.; Diefenbach, K.A.; et al. Ovarian masses in the child and adolescent: An American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee systematic review. J. Pediatr. Surg. 2019, 54, 369–377. [Google Scholar] [CrossRef]
- Spinelli, C.; Piscioneri, J.; Strambi, S. Adnexal torsion in adolescents: Update and review of the literature. Curr. Opin. Obstet. Gynecol. 2015, 27, 320–325. [Google Scholar] [CrossRef]
- Spinelli, C.; Strambi, S.; Masoni, B.; Ghionzoli, M.; Bertocchini, A.; Sanna, B.; Morganti, R.; Messina, M.; Molinaro, F.; Tursini, S.; et al. Surgical management of ovarian teratomas in childhood: A multicentric study on 110 cases and a literature review. Gynecol. Endocrinol. 2021, 37, 950–954. [Google Scholar] [CrossRef]
- Spinelli, C.; Pucci, V.; Buti, I.; Liserre, J.; Messineo, A.; Bianco, F.; Ugolini, C. The Role of Tumor Markers in the Surgical Approach of Ovarian Masses in Pediatric Age: A 10-Year Study and a Literature Review. Ann. Surg. Oncol. 2012, 19, 1766–1773. [Google Scholar] [CrossRef] [PubMed]
- Loh, A.H.P.; Gee, K.W.C.; Chua, J.H.Y. Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: Not as good as we thought? Pediatr. Surg. Int. 2013, 29, 709–713. [Google Scholar] [CrossRef] [PubMed]
- Kaijser, J.; Bourne, T.; Valentin, L.; Sayasneh, A.; Van Holsbeke, C.; Vergote, I.; Testa, A.C.; Franchi, D.; Van Calster, B.; Timmerman, D. Improving strategies for diagnosing ovarian cancer: A summary of the International Ovarian Tumor Analysis (IOTA) studies. Ultrasound Obstet. Gynecol. 2013, 41, 9–20. [Google Scholar] [CrossRef]
- Spinelli, C.; Strambi, S.; Liloia, C.; Bertocchini, A.; Messineo, A. Update on the surgical management of ovarian neoplasms in children and adolescents: Analysis on 32 cases. Gynecol. Endocrinol. 2016, 32, 787–791. [Google Scholar] [CrossRef]
- Braungart, S.; Craigie, R.J.; Losty, P.D. Controversies in the management of ovarian tumours in prepubertal children — A BAPS and UK CCLG Surgeons Cancer Group National Survey. J. Pediatr. Surg. 2018, 53, 2231–2234. [Google Scholar] [CrossRef]
- Hayes-Jordan, A. Surgical management of the incidentally identified ovarian mass. Semin. Pediatr. Surg. 2005, 14, 106–110. [Google Scholar] [CrossRef] [PubMed]
- Malkan, A.D.; Loh, A.H.; Sandoval, J.A. Minimally invasive surgery in the management of abdominal tumors in children. J. Pediatr. Surg. 2014, 49, 1171–1176. [Google Scholar] [CrossRef] [PubMed]
- Gonzalez, D.O.; Cooper, J.N.; Aldrink, J.H.; Hewitt, G.D.; Fallat, M.E.; Minneci, P.C.; Deans, K.J. Variability in surgical management of benign ovarian neoplasms in children. J. Pediatr. Surg. 2017, 52, 944–950. [Google Scholar] [CrossRef]
- Rousseau, V.; Massicot, R.; Darwish, A.A.; Sauvat, F.; Emond, S.; Thibaud, E.; Nihoul-Fékété, C. Emergency Management and Conservative Surgery of Ovarian Torsion in Children: A Report of 40 Cases. J. Pediatr. Adolesc. Gynecol. 2008, 21, 201–206. [Google Scholar] [CrossRef]
Item | Our Series (n = 40) | Literature (n = 1418) |
---|---|---|
Mean age at diagnosis | 11.8 | 10.4 |
Adnexal torsion | 12 | 481 |
Biochemical markers elevated | 8 | 57 |
Oophorectomy | 30 | 463 |
Ovary-sparing surgery | 10 | 131 |
Laparoscopic approach | 6 | 128 |
Laparotomic approach | 34 | 466 |
Acute abdominal pain | 12 | 506 |
Chronic abdominal pain | 27 | 192 |
Palpable mass | Not mentioned | 146 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Gkrozou, F.; Tsonis, O.; Vatopoulou, A.; Galaziou, G.; Paschopoulos, M. Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature. Children 2022, 9, 1571. https://doi.org/10.3390/children9101571
Gkrozou F, Tsonis O, Vatopoulou A, Galaziou G, Paschopoulos M. Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature. Children. 2022; 9(10):1571. https://doi.org/10.3390/children9101571
Chicago/Turabian StyleGkrozou, Fani, Orestis Tsonis, Anastasia Vatopoulou, Georgia Galaziou, and Minas Paschopoulos. 2022. "Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature" Children 9, no. 10: 1571. https://doi.org/10.3390/children9101571
APA StyleGkrozou, F., Tsonis, O., Vatopoulou, A., Galaziou, G., & Paschopoulos, M. (2022). Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature. Children, 9(10), 1571. https://doi.org/10.3390/children9101571