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Wharton’s Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499
Systematic Review

The Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review

1
Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
2
The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
3
Master Program in Clinical Genomics and Proteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
4
Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, China
5
Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
6
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
*
Author to whom correspondence should be addressed.
Academic Editor: Andrea Farini
Biomedicines 2021, 9(9), 1097; https://doi.org/10.3390/biomedicines9091097
Received: 22 July 2021 / Revised: 19 August 2021 / Accepted: 23 August 2021 / Published: 27 August 2021
As one of the most common genetic conditions, Duchenne muscular dystrophy (DMD) is a fatal disease caused by a recessive mutation resulting in muscle weakness in both voluntary and involuntary muscles and, eventually, in death because of cardiovascular failure. Currently, there is no pharmacologically curative treatment of DMD, but there is evidence supporting that mesenchymal stem cells (MSCs) are a novel solution for treating DMD. This systematic review focused on elucidating the therapeutic efficacy of MSCs on the DMD in vivo model. A key issue of previous studies was the material-choice, naïve MSCs or modified MSCs; modified MSCs are activated by culture methods or genetic modification. In summary, MSCs seem to improve pulmonary and cardiac functions and thereby improve survival regardless of them being naïve or modified. The improved function of distal skeletal muscles was observed only with primed MSCs treatment but not naïve MSCs. While MSCs can provide significant benefits to DMD mouse models, there is little to no data on the results in human patients. Due to the limited number of human studies, the differences in study design, and the insufficient understanding of mechanisms of action, more rigorous comparative trials are needed to elucidate which types of MSCs and modifications have optimal therapeutic potential. View Full-Text
Keywords: mesenchymal stem cells Duchenne muscular dystrophy; muscle function; fibrosis; regenerative cell therapy; contraction-induced injury mesenchymal stem cells Duchenne muscular dystrophy; muscle function; fibrosis; regenerative cell therapy; contraction-induced injury
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MDPI and ACS Style

Shen, O.Y.-J.; Chen, Y.-F.; Xu, H.-T.; Lee, C.-W. The Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review. Biomedicines 2021, 9, 1097. https://doi.org/10.3390/biomedicines9091097

AMA Style

Shen OY-J, Chen Y-F, Xu H-T, Lee C-W. The Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review. Biomedicines. 2021; 9(9):1097. https://doi.org/10.3390/biomedicines9091097

Chicago/Turabian Style

Shen, Oscar Y.-J., Yi-Fan Chen, Hong-Tao Xu, and Chien-Wei Lee. 2021. "The Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review" Biomedicines 9, no. 9: 1097. https://doi.org/10.3390/biomedicines9091097

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