Enhanced Fuzzy Elephant Herding Optimization-Based OTSU Segmentation and Deep Learning for Alzheimer’s Disease Diagnosis

: Several neurological illnesses and diseased sites have been studied, along with the anatomical framework of the brain, using structural MRI (sMRI). It is critical to diagnose Alzheimer’s disease (AD) patients in a timely manner to implement preventative treatments. The segmentation of brain anatomy and categorization of AD have received increased attention since they can deliver good ﬁndings spanning a vast range of information. The ﬁrst research gap considered in this work is the real-time efﬁciency of OTSU segmentation, which is not high, despite its simplicity and good accuracy. A second issue is that feature extraction could be automated by implementing deep learning techniques. To improve picture segmentation’s real-timeliness, enhanced fuzzy elephant herding optimization (EFEHO) was used for OTSU segmentation, and named EFEHO-OTSU. The main contribution of this work is twofold. One is utilizing EFEHO in the recommended technique to seek the optimal segmentation threshold for the OTSU method. Second, dual attention multi-instance deep learning network (DA-MIDL) is recommended for the timely diagnosis of AD and its prodromal phase, mild cognitive impairment (MCI). Tests show that this technique converges faster and takes less time than the classic OTSU approach without reducing segmentation performance. This study develops a valuable tool for quick picture segmentation with good real-time efﬁciency. Compared to numerous conventional techniques, the suggested study attains improved categorization performance regarding accuracy and


Introduction
The most prominent type of dementia is Alzheimer's disease (AD), accompanied by a gradual decline in cognitive capabilities. Its symptoms range from forgetfulness in the early phases to speech loss and immobility in the late phases. Alzheimer's, on the other hand, differs from other geriatric diseases in that its initial symptoms are frequently confounded with those of old age, and its commencement is commonly missed. According to the Alzheimer's and Related Disorders Society of India (ARDSI)'s Dementia India Report

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Initially, the two AD database such as ADNI and AIBL are taken as the input. • Then, the pre-processing steps such as geometry correction, linear registration and skull-stripping are done. • Third, EFEHO to OTSU is suggested for segmentation. • Finally, the findings show that our DA-MIDL technique beats numerous existing techniques regarding reliability and generality.
The remaining article is structured as: Section 2 discusses conventional approaches, Section 3 briefs the suggested segmentation technique and DA-MIDL technique, Section 4 depicts the experimental findings and outcomes for various AD diagnosis tasks, and Section 5 concludes with future directions.

Related Work
Numerous studies in the literature were committed to building automatic strategies to monitor AD-related functional and structural brain abnormalities.

Meta-Heuristic Algorithms
Mirjalili et al. [11] proposed Grey Wolf Optimizer inspired by grey wolves, and the findings on the unimodal functions demonstrate the way in which GWO is used efficiently. The exploration capability of GWO is corroborated by the results on multimodal functions. The results achieved with semi-real and actual issues show the practical performance of GWO.
Zamani et al. [12] presented an innovative bio-inspired algorithm based on starlings' behaviors during their exciting murmuration referred to as starling murmuration optimizer (SMO), which helps in solving complicated and engineering optimization issues to be the best appropriate application for metaheuristic algorithms.
Nadimi-Shahraki et al. [13] proposed a migration-based moth-flame optimization (M-MFO) algorithm. M-MFO is chiefly focused on enhancing the location of unfortunate moths by migrating them at random during the initial iterations utilizing a random migration (RM) operator, maintaining the solution's versatility by saving new qualified solutions individually in a guiding repository, and, finally, working around the positions stored in the guiding repository, applying a guided migration (GM) operator.
Therefore, various kinds of metaheuristic algorithms are required for the approximation of the best solutions for various optimization problems, and this represents the basic inspiration for scholars to enhance the present metaheuristic algorithms or propose innovative techniques specifically for segmentation.

Machine Learning and Deep Learning Algorithms
Fan et al. [14] and Magnin et al. [15] used an SVM approach to categorize and forecast distinct AD operations using structural brain magnetic resonance imaging (MRI) information. The SVM technique and extracted MRI information are integrated into this paper to improve categorization diagnosis outcomes.
Liu et al. [16] explicitly modelled structural information in multi-template information, as is recommended for automatic detection of AD and its premonitory phase, MCI. Finally, an ensemble categorization is utilized to integrate the outputs of all SVM classifiers. Li et al. [17] developed a powerful deep learning procedure to recognize AD progression phases using MRI and PET information. The dropout strategy improved deep classical learning by eliminating weight coadaptation, a common cause of overfitting. The deep learning framework includes stability picking, adaptive learning, and multitask learning. Using brain network connectivity pattern analysis, Wang et al. [18] provided a robust technique for AD, MCI, and standard control subject categorization in size constrained fMRI information samples. The suggested regularized LDA is then used to project the feature vectors onto a one-dimensional axis. Lastly, to complete the categorization task, an AdaBoost classifier is used.
LeNet, as with most DNN techniques, employs a MaxPooling layer to reduce dimensionality by removing information from minimum valued elements. To maintain the network's minimal valued elements, we constructed an individual layer that performs the Min-Pooling function by Hazarika et al. [19]. Zhu et al. [20] presented a DA-MIDL for the timely detection of AD and MCI in its premonitory phase.
Song et al. [21] suggested an AMGNN technique for AD diagnosis. First, a metricbased meta-learning technique for independent testing is introduced. To improve performance under minor sample size conditions, tiny graphs are used in the meta-tasks. However, it is not easy to apply CNNs for AD diagnosis due to the scarcity of imaging information. We devise a revolutionary deep learning framework by Feng et al. [22]. As a comparison approach, the HFCN paradigm was used by Liu et al. [23]. Lian et al. [24] built a DMIL framework utilizing patch-wise input information. In addition to diagnosis, AD segmentation gives structural information about aberrant and normal tissues. It is regarded as a texture categorization issue.

Hybrid Model
Abuhmed et al. [25] designed and assessed two new hybrid deep learning models for AD progression detection. These models depend on the combination of several deep bidirectional long short-term memory (BiLSTM) frameworks.
Basheera et al. [26] studied a new multiclass classification of Alzheimer's disease that employs convolution neural network. A total of 18,017 magnetic resonance imaging fragments are gathered from 1820 T2-MRI volumes. Hybrid enhanced independent component analysis was utilized to carry out the segmentation. Segmented gravy matter was considered for the classification process. The proposed technique performs better both in the form of a binary classifier and multiclass classifier.
Although the above-discussed techniques attained good results in the detection of AD. The SVM has a limitation in that the feature extraction step needs a human expert, and this thus reduces the accuracy as wel1. Although the above-discussed DL methods are good in automatic feature extraction, all are good in a small dataset. So, this work focused on solving these two main issues through the proposed DA-MIDL method.

Proposed Methodology for AD Detection
Usually, medical images have inhomogeneity, strange noise, and a complex structure. Thus, medical image segmentation is a difficult task for denoising and deblurring. Applying EFEHO to the OTSU strategy is employed for image segmentation. Figure 1 depicts the proposed AD detection's basic outline. Then, we present the DA-MIDL AD detection technique.
Mathematics 2022, 10, x FOR PEER REVIEW 4 of 14 considered for the classification process. The proposed technique performs better both in the form of a binary classifier and multiclass classifier. Although the above-discussed techniques attained good results in the detection of AD. The SVM has a limitation in that the feature extraction step needs a human expert, and this thus reduces the accuracy as wel1. Although the above-discussed DL methods are good in automatic feature extraction, all are good in a small dataset. So, this work focused on solving these two main issues through the proposed DA-MIDL method.

Proposed Methodology for AD Detection
Usually, medical images have inhomogeneity, strange noise, and a complex structure. Thus, medical image segmentation is a difficult task for denoising and deblurring. Applying EFEHO to the OTSU strategy is employed for image segmentation. Figure 1 depicts the proposed AD detection's basic outline. Then, we present the DA-MIDL AD detection technique.

Input Database and Image Pre-Processing
The Alzheimer's Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu (accessed on 3 January 2022) was utilized to compile the data for this article (adni.loni.usc.edu). The principal investigator Michael W. Weiner, MD, founded the ADNI in 2003 as a public-private cooperation. The major purpose of ADNI was to see whether serial MRI, PET, other biological markers, and clinical and neuropsychological assessments could be used to track the evolution of mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Visit www.adni-info.org for the most up-todate information. The Australian Imaging, Biomarker and Lifestyle Flagship Work of Ageing (AIBL) database (https://aibl.csiro.au (accessed on 3 January 2022)) was used in this study. The data were collected by the AIBL study group. The AIBL study's methodology has been reported previously [27].

Input Database and Image Pre-Processing
The Alzheimer's Disease Neuroimaging Initiative (ADNI) database (http://adni.loni. usc.edu (accessed on 3 January 2022)) was utilized to compile the data for this article (adni.loni.usc.edu). The principal investigator Michael W. Weiner, MD, founded the ADNI in 2003 as a public-private cooperation. The major purpose of ADNI was to see whether serial MRI, PET, other biological markers, and clinical and neuropsychological assessments could be used to track the evolution of mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Visit www.adni-info.org (accessed on 3 January 2022) for the most up-to-date information. The Australian Imaging, Biomarker and Lifestyle Flagship Work of Ageing (AIBL) database (https://aibl.csiro.au (accessed on 3 January 2022)) was used in this study. The data were collected by the AIBL study group. The AIBL study's methodology has been reported previously [27].

Segmentation Using EFEHO to OTSU Technique
Owing to its simplicity and precision, OTSU segmentation is inefficient in real-time. This study introduces EFEHO to OTSU segmentation, establishing an EFEHO-OTSU segmentation procedure. The suggested procedure searches for the appropriate OTSU threshold for segmentation, effectively segmenting the image's background and target, resulting in the best effect and lowest calculation cost. Each metaheuristic algorithm discussed in related work has specific advantages and weaknesses. If one algorithm uses minimum memory, less running time, and has improved final function value then that algorithm is considered as the best algorithm for the given dataset. By means of the comparison process [28], the best optimization algorithm EHO is chosen for segmentation.
OTSU image segmentation technique: The OTSU technique uses a single threshold to divide an image into the foreground and background. If the total amount of pixels in the image is T, the probability P of all pixel points for a given greyscale value is In which i is the grey value, and T i is the amount of pixels. Considering the image to be segmented as per the threshold th, the probability P i of the number of pixels k occurring in the foreground Ω 0 and background areas Ω 1 is Additionally, the interclass variance Y of the two areas segmented by the threshold th is where µ is the mean value of the image, and µ 0 and µ 1 are the mean value of the target area and the background area, respectively. Assuming that the image grey level is S and that the threshold group th 1 , th 2 , . . . , th n (0 ≤ th 1 ≤ th 2 ≤ th n ≤ S − 1) divides the image into t + 1 individual intervals, the total variance between classes is where Ω i and Ω j are the probability of two areas. µ i and µ j are the means of two portions.
Elephant herding optimization: The EHO technique was suggested by [29] and is a SI technique. It is inspired by elephant herding behavior in nature. This behavior is summarized as follows. Elephants are divided into subgroups called clans, each with several elephants. A matriarch leads each clan, while adult male elephants leave their clans and live alone. In EHO, these actions are led by two operators: clan update and clan separation Clan update shifts elephants and matriarchs around in each clan, while separation increases population variety later in the search phase.
Separating operator and clan updating operator are EHO behavior categorizations. EHO beats existing procedures for pattern matching. EHO procedure is defined as follows. An elephant El group is led by a matriarch, usually the eldest cow. Each member 'j' of clan 'i' shifts according to the matriarch where the matriarch is the elephant cl i with the best fitness value in a generation: In clan i, Elnew ,cl i,j depicts an elephant j in its present location and El cl i,j is its previous location. The best solution of clan cl i is the Elbest cl i , where α ∈ [0, 1] is a scale factor of the procedure that recognizes the matriarch position of the best elephant in clan El bert,cl i : 1] is the second parameter of the procedure that controls the influence of the Elcenter cl i defined as the clan-updating process: is the dimension of the dth term and denotes the dimension total space, and n cl i recognizes an unlimited number of elephants in clan i. In each clan i elephants, which is shifted to the fresh positions as per the below equation (separating process): where El min and El max are the minimum and maximum bound of the search space, and rand [0, 1] is a stochastic distribution between 0 and 1. EFEHO: To distinguish EHO from other population-based evolutionary procedures, each candidate solution is linked to a matriarch. Here, "member" and "clan" are possible solutions through the search space. A population of elephants is formed to build the EHO procedure. The matriarch position of each elephant is then altered based on the elephant's and the clan's experiences. The elephants should move towards better solutions. Every elephant's fitness can be assessed using an optimization problem's objective function. The authors employed a fuzzy system called Fuzzy PSO (FPSO) to propose stabilized fitness of the recent best position of ith elephant (SFRBP (El i )). This input is: where Fitness Elbest k i is the fitness of the best previous position of ith elephant in kth iteration, Fitness KN is the known real optimal solution value, and Fitness Elbest 1 i is the fitness of the of ith in 1st iteration. The second fuzzy input is the current value of the scale factor for ith elephant El i . The fuzzy output is a variation of factor cl i . Each fuzzy variable has three membership functions, namely small (Sm), medium (Me) and large (La), as below: where µ denotes the membership function, and cl 1 and cl 2 are the crisp inputs of clan of elephants. The improved fuzzy rules are shown in Table 1. To analyse the effectiveness of the above techniques, we detect an inconstant nonlinear system where the real parameters are assumed to be θ = [θ 1 , θ 2 , θ 3 , θ 4 ] = [0.5, 0.3, 1.8, 0.9]. The known optimal value Fitness KN is set to zero for the EFEHO. The optimization is repeated 20 times. To optimise the parameters θ 1 , θ 2 , θ 3 and θ 4 , the EFEHO procedure is used. The EFHEO achieves great precision and fast convergence without premature convergence. The goal is to apply the EFHEO technique to recognize system parameters (optimal elephants) used for OTSU segmentation. The EFHEO-OTSU image segmentation procedure steps are discussed below and illustrated in Figure 2: (1) The image must be retrieved and pre-processed.

AD Detection Using DA-MIDL
Our technique is based on multi-instance learning. Bags are used to represent training information in MIL. The bag-level label of each sample/bag is stored in the bag-level label of each bag. X_i = {I_(i,j) }_(j = 1)^(N_i), where I (i,j) is the j-th instance and N i is the number of occurrences in X_i. Y_i = 0 only when ∑_(j = 0)^(N_i) ▒ y_(i,j) = 0, otherwise Y_i = 1. Localized brain atrophy occurs early in AD. We consider a patient's MR patch bag to be a positive bag to this aim. The hyper parameter is given in Table 2. y_(i,j) = 0, otherwise Y_i = 1. Localized brain atrophy occurs early in AD. We consider a patient's MR patch bag to be a positive bag to this aim. The hyper parameter is given in Table 2.
Similarly, we put standard control patches in a harmful bag. Thus, many patch bags with bag-level labels replace huge photos as training information for AD diagnosis. In the recommended DA-MIDL technique (Figure 3), four phases are involved: selecting instances for a bag X, transforming instance-level features (Patch-Net), combining altered illustrations (Attention MIL Pooling), and classifying the combined bag-level features (G) (i.e., Attention-Aware Global Classifier).

AD Detection Using DA-MIDL
Our technique is based on multi-instance learning. Bags are used to repre ing information in MIL. The bag-level label of each sample/bag is stored in th label of each bag. X_i = {I_(i,j) }_(j = 1)^(N_i), where I (i,j) is the j-th instance an number of occurrences in X_i. Y_i = 0 only when ∑_(j = 0)^(N_i)▒y_(i,j) = 0, oth = 1. Localized brain atrophy occurs early in AD. We consider a patient's MR p  loss hyper-parameters (weight is λ and temperature parameter is τ) 0.5 and 1.0, respectively Similarly, we put standard control patches in a harmful bag. Thus, many patch bags with bag-level labels replace huge photos as training information for AD diagnosis. In the recommended DA-MIDL technique (Figure 3), four phases are involved: selecting instances for a bag X, transforming instance-level features (Patch-Net), combining altered illustrations (Attention MIL Pooling), and classifying the combined bag-level features (G) (i.e., Attention-Aware Global Classifier).  [20]. Reprinted with permission from ref. [20]. Copyright 2021 IEEE.

Experimental Outcomes and Discussions
The outcomes of our DA-MIDL with a segmentation approach and the competing techniques on the test set from the ADNI AIBL dataset for AD categorization and MCI conversion diagnosis are shown below. The recommended DA-MIDL technique with optimal OTSU surpasses the other competing techniques (DA-MIDL [20], HFCN [23], and proposed DA-MIDL with segmentation). The DA-MIDL technique with segmentation has been validated on a variety of AD-related diagnosis tasks, including AD categorization (AD vs. NC), MCI conversion diagnosis (pMCI vs. sMCI), and MCI categorization (pMCI vs. NC and sMCI vs. NC). In this case, three measures are used to evaluate categorization effectiveness: accuracy, sensitivity, and specificity. The measurements are described as follows:   [20]. Reprinted with permission from ref. [20]. Copyright 2021 IEEE.

Experimental Outcomes and Discussions
The outcomes of our DA-MIDL with a segmentation approach and the competing techniques on the test set from the ADNI AIBL dataset for AD categorization and MCI conversion diagnosis are shown below. The recommended DA-MIDL technique with optimal OTSU surpasses the other competing techniques (DA-MIDL [20], HFCN [23], and proposed DA-MIDL with segmentation). The DA-MIDL technique with segmentation has been validated on a variety of AD-related diagnosis tasks, including AD categorization (AD vs. NC), MCI conversion diagnosis (pMCI vs. sMCI), and MCI categorization (pMCI vs. NC and sMCI vs. NC). In this case, three measures are used to evaluate categorization effectiveness: accuracy, sensitivity, and specificity. The measurements are described as follows:

Accuracy Comparison Outcomes
The recommended technique has superior qualities regarding consistent convergence characteristics and good computational exactness. As demonstrated in Figure 4, the suggested DA-MIDL technique with segmentation usually beats the other DMIL and HFCN in both AD-related diagnosis tasks. For illustration, the DA-MIDL with segmentation achieves the best accuracy of 0.942 on the ADNI dataset, greater than DA-MIDL and HFCN. For the AIBL categorization challenge, the DA-MIDL with segmentation technique also produces a higher outcome of 0.865, which is higher than those of the previous techniques. This finding suggests that DA-MIDL with the segmentation technique can deliver robust performance across multiple databases.
Mathematics 2022, 10, x FOR PEER REVIEW

Accuracy Comparison Outcomes
The recommended technique has superior qualities regarding consist gence characteristics and good computational exactness. As demonstrated in F suggested DA-MIDL technique with segmentation usually beats the other HFCN in both AD-related diagnosis tasks. For illustration, the DA-MIDL with tion achieves the best accuracy of 0.942 on the ADNI dataset, greater than DA HFCN. For the AIBL categorization challenge, the DA-MIDL with segmen nique also produces a higher outcome of 0.865, which is higher than those of t techniques. This finding suggests that DA-MIDL with the segmentation techni liver robust performance across multiple databases.

Sensitivity Comparison Outcomes
As shown in Figure 5, the recommended DA-MIDL technique with segme sically beats the other DA-MIDL and HFCN in both AD-related diagnosis ta ample, the DA-MIDL with segmentation attains better sensitivity (0.923) on th taset, which is better than DA-MIDL, and HFCN. For the AIBL categorizatio DA-MIDL with the segmentation technique also obtains better outcomes of 0.9 to the existing process. These outcomes suggest that the DA-MIDL segmen nique can improve robust performance across different datasets.

Sensitivity Comparison Outcomes
As shown in Figure 5, the recommended DA-MIDL technique with segmentation basically beats the other DA-MIDL and HFCN in both AD-related diagnosis tasks. For example, the DA-MIDL with segmentation attains better sensitivity (0.923) on the ADNI dataset, which is better than DA-MIDL, and HFCN. For the AIBL categorization task, the DA-MIDL with the segmentation technique also obtains better outcomes of 0.93, superior to the existing process. These outcomes suggest that the DA-MIDL segmentation technique can improve robust performance across different datasets.

Specificity Comparison Outcomes
As shown in Figure 6, the recommended DA-MIDL technique with segmentation basically outperforms the other DA-MIDL and HFCN in both AD-related diagnosis tasks. For example, the DA-MIDL with segmentation achieves the best sensitivity 0.92 on the ADNI dataset, which is better than DA-MIDL and HFCN. For the AIBL categorization task, the DA-MIDL with the segmentation technique also obtains a better outcome of 0.93, superior to the existing process. From the overall performance of specificity outcomes, the recommended DA-MIDL with segmentation attained high specificity mainly because integrating fuzzy and EHO procedures helped to reach a global optimum without getting stuck at a local optimum. The segmented AD area is initially sent to the feature extraction module, where the features are extracted. The categorization module uses the DA-MIDL classifier to detect the AD.

Accuracy Comparison Outcomes
The recommended technique has superior qualities regarding consiste gence characteristics and good computational exactness. As demonstrated in F suggested DA-MIDL technique with segmentation usually beats the other HFCN in both AD-related diagnosis tasks. For illustration, the DA-MIDL with tion achieves the best accuracy of 0.942 on the ADNI dataset, greater than DA HFCN. For the AIBL categorization challenge, the DA-MIDL with segment nique also produces a higher outcome of 0.865, which is higher than those of th techniques. This finding suggests that DA-MIDL with the segmentation techniq liver robust performance across multiple databases.

Sensitivity Comparison Outcomes
As shown in Figure 5, the recommended DA-MIDL technique with segme sically beats the other DA-MIDL and HFCN in both AD-related diagnosis tas ample, the DA-MIDL with segmentation attains better sensitivity (0.923) on the taset, which is better than DA-MIDL, and HFCN. For the AIBL categorizatio DA-MIDL with the segmentation technique also obtains better outcomes of 0.9 to the existing process. These outcomes suggest that the DA-MIDL segment nique can improve robust performance across different datasets.  Mathematics 2022, 10, x FOR PEER REVIEW

Specificity Comparison Outcomes
As shown in Figure 6, the recommended DA-MIDL technique with seg sically outperforms the other DA-MIDL and HFCN in both AD-related di For example, the DA-MIDL with segmentation achieves the best sensitivi ADNI dataset, which is better than DA-MIDL and HFCN. For the AIBL c task, the DA-MIDL with the segmentation technique also obtains a better ou superior to the existing process. From the overall performance of specificity recommended DA-MIDL with segmentation attained high specificity main tegrating fuzzy and EHO procedures helped to reach a global optimum w stuck at a local optimum. The segmented AD area is initially sent to the feat module, where the features are extracted. The categorization module uses classifier to detect the AD.

AUC Comparison Outcomes
The findings show that the recommended technique attains high AUC mized OTSU multi-threshold segmentation based on EFEHO does not easi optimal local solution, and its stability is better. As shown in Figure 7, the r DA-MIDL technique with segmentation basically outperforms the other DM in both AD-related diagnosis tasks. For example, the DA-MIDL with achieves the best sensitivity 0.923 on the ADNI dataset, which is better th

AUC Comparison Outcomes
The findings show that the recommended technique attains high AUC because optimized OTSU multi-threshold segmentation based on EFEHO does not easily fall into the optimal local solution, and its stability is better. As shown in Figure 7, the recommended DA-MIDL technique with segmentation basically outperforms the other DMIL and HFCN in both AD-related diagnosis tasks. For example, the DA-MIDL with segmentation achieves the best sensitivity 0.923 on the ADNI dataset, which is better than DA-MIDL and HFCN. For the AIBL categorization task, the DA-MIDL with the segmentation technique also acquires a good outcome of 0.93, superior to the existing process.

AUC Comparison Outcomes
The findings show that the recommended technique attains high AUC because opti mized OTSU multi-threshold segmentation based on EFEHO does not easily fall into th optimal local solution, and its stability is better. As shown in Figure 7, the recommended DA-MIDL technique with segmentation basically outperforms the other DMIL and HFCN in both AD-related diagnosis tasks. For example, the DA-MIDL with segmentatio achieves the best sensitivity 0.923 on the ADNI dataset, which is better than DA-MIDL and HFCN. For the AIBL categorization task, the DA-MIDL with the segmentation tech nique also acquires a good outcome of 0.93, superior to the existing process.

Execution Time Comparison Outcome
The validation phase execution time is provided in Figure 8 in accordance with current studies in the process of evaluating the performance of the proposed model. Over the course of 20 epochs, the suggested model took around 100 s to train. The time it took to compute DA-MIDL and HFCN did not decrease significantly. Other performance evolution indicators such as sensitivity, specificity, and accuracy showed that DA-MIDL with segmentation had a superior prediction accuracy.

Execution Time Comparison Outcome
The validation phase execution time is provided in Figure 8 in accordance with cur rent studies in the process of evaluating the performance of the proposed model. Over th course of 20 epochs, the suggested model took around 100 s to train. The time it took to compute DA-MIDL and HFCN did not decrease significantly. Other performance evolu tion indicators such as sensitivity, specificity, and accuracy showed that DA-MIDL with segmentation had a superior prediction accuracy.

Conclusions and Future Work
The timely screening of AD and MCI is critical for patient care and research. It i commonly acknowledged that preventive actions are critical in delaying or reducing th

Conclusions and Future Work
The timely screening of AD and MCI is critical for patient care and research. It is commonly acknowledged that preventive actions are critical in delaying or reducing the onset of AD. The primary problems for the categorization task of distinct phases of AD progression are the smaller number of training samples and the greater number of feature representations. This work uses computer image processing techniques to address this issue. It combines an optimized OTSU multi-threshold segmentation based on EFEHO with a DA-MIDL for computer-aided AD diagnosis. Our recommended DA-MIDL technique was tested on 1689 patients from two separate datasets in several AD-related diagnosis tests. The impact of picture segmentation means that the identification retains its original accuracy, considerably enhancing image segmentation speed and matching real-time processing needs. The test outcomes show that our technique can detect discriminative abnormal areas in sMRI scans and outperform various conventional approaches.
Research is being done to increase accuracy by developing classifiers, potentially using an ensemble technique and feature selection. In addition, we will investigate the implementation of automatic hyperparameter tweaking, utilizing the deep learning technique and various optimization techniques, in future work.