Next Article in Journal / Special Issue
Nuclear Transport of Yeast Proteasomes
Previous Article in Journal / Special Issue
Cullin E3 Ligases and Their Rewiring by Viral Factors
Article Menu

Export Article

Open AccessArticle
Biomolecules 2014, 4(4), 931-939;

Inhibitory Effect of b-AP15 on the 20S Proteasome

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Author to whom correspondence should be addressed.
Received: 5 June 2014 / Revised: 5 August 2014 / Accepted: 23 September 2014 / Published: 14 October 2014
(This article belongs to the Special Issue Proteasomes and Its Regulators)
Full-Text   |   PDF [4262 KB, uploaded 14 October 2014]   |  


The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles. View Full-Text
Keywords: proteasome inhibitor; b-AP15; 19S regulatory particles proteasome inhibitor; b-AP15; 19S regulatory particles

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Huang, L.; Jung, K.; Chen, C.H. Inhibitory Effect of b-AP15 on the 20S Proteasome. Biomolecules 2014, 4, 931-939.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top