Next Article in Journal
Self-Medication with Antibiotics, Attitude and Knowledge of Antibiotic Resistance among Community Residents and Undergraduate Students in Northwest Nigeria
Next Article in Special Issue
Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases
Previous Article in Journal
Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report)
Previous Article in Special Issue
Update Treatment for HBV Infection and Persistent Risk for Hepatocellular Carcinoma: Prospect for an HBV Cure
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessFeature PaperCommunication
Diseases 2018, 6(2), 31; https://doi.org/10.3390/diseases6020031

Hepatitis C in Pregnancy

1
Department of Gastroenterology, Women & Infants Hospital/Warren Alpert School of Medicine, Brown University, Providence, RI 02905, USA
2
Department of Medicine, Roger Williams Medical Center, Providence, RI 02908, USA
3
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94304, USA
4
Department of Hematology/Oncology, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA
*
Author to whom correspondence should be addressed.
Received: 27 March 2018 / Revised: 20 April 2018 / Accepted: 23 April 2018 / Published: 27 April 2018
(This article belongs to the Special Issue Hepatitis and Treatment)
Full-Text   |   PDF [297 KB, uploaded 3 May 2018]

Abstract

The prevalence of hepatitis C in pregnancy is as high as 3.6% in large cohorts. The prevalence of hepatitis C acquired by vertical transmission is 0.2% to 0.4% in the United States and Europe. Although screening is not recommended in the absence of certain risk factors, the importance of understanding hepatitis C in pregnancy lies in its association with adverse maternal and neonatal outcomes. There is potential for those infants infected by vertical transmission to develop chronic hepatitis C, cirrhosis or hepatocellular carcinoma. The risk of vertical transmission is increased when mothers are co-infected with Human Immunodeficiency Virus (HIV) or possess a high viral load. There is no clear data supporting that mode of delivery increases or reduces risk. Breastfeeding is not associated with increased risk of transmission. Premature rupture of membranes, invasive procedures (such as amniocentesis), intrapartum events, or fetal scalp monitoring may increase risk of transmission. In pregnant patients, hepatitis C is diagnosed with a positive ELISA-3 and detectable Hepatitis C Virus (HCV) RNA viral load. Infants born to HCV-infected mothers should be tested for either HCV RNA on at least two separate occasions. Although prevention is not possible, there may be a role for newer direct acting anti-viral medications in the future. View Full-Text
Keywords: hepatitis C virus infection; pregnancy hepatitis C virus infection; pregnancy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Dibba, P.; Cholankeril, R.; Li, A.A.; Patel, M.; Fayek, M.; Dibble, C.; Okpara, N.; Hines, A.; Ahmed, A. Hepatitis C in Pregnancy. Diseases 2018, 6, 31.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diseases EISSN 2079-9721 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top