Next Article in Journal
Fingerprint Blurring on a Hierarchical Nanoporous Layer Glass
Previous Article in Journal
Morphology, Structure, and Properties of Conductive Polylactide Fibers Prepared Using Polyvinyl Acetate and Multiwalled Carbon Nanotubes
Previous Article in Special Issue
Custom-Made Chemically Modified Graphene Oxide to Improve the Anti-Scratch Resistance of Urethane-Acrylate Transparent Coatings
Open AccessFeature PaperArticle

Graphene–Gold Nanostructures Hybrid Composites Screen-Printed Electrode for the Sensitive Electrochemical Detection of Vancomycin

Department of Analytical Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 4 Pasteur Street, 400349 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Coatings 2019, 9(10), 652; https://doi.org/10.3390/coatings9100652
Received: 29 August 2019 / Revised: 26 September 2019 / Accepted: 8 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Graphene-Based Composite Films)
The most important and well-known glycopeptide antibiotic, vancomycin (VAN), is used for the treatment of severe bacterial infections like methicillin-resistant staphylococcal infections and endocarditis caused by enterococci and sepsis. Taking into account the problem of the development of antibiotic resistance as well as its toxicity, both correlated with the VAN concentration (CVAN) in biological samples, there is need for better and more accessible quantification methods for this antibiotic. Considering all of the above, herein, we present a simple electrochemical method for VAN sensing based on a hybrid graphene-gold nanostructure nanocomposite electrode, which allows double detection directly in the oxidation domain and also indirectly, in reduction, using the electro-active gold nanostructures as a probe to monitor the current changing due to the interaction between gold and VAN. The developed method was able to successfully detect VAN in the linear range of 1–100 µM with a limit of detection (LOD) of 0.29 µM for the direct approach and 0.5 µM for the indirect one. The selectivity of the method was tested in the presence of other antibiotics and drugs. This method was successfully applied for the detection of VAN from human serum samples. View Full-Text
Keywords: vancomycin; graphene; screen printed electrodes; antibiotic detection; gold nanostructures vancomycin; graphene; screen printed electrodes; antibiotic detection; gold nanostructures
Show Figures

Graphical abstract

MDPI and ACS Style

Blidar, A.; Feier, B.; Pusta, A.; Drăgan, A.-M.; Cristea, C. Graphene–Gold Nanostructures Hybrid Composites Screen-Printed Electrode for the Sensitive Electrochemical Detection of Vancomycin. Coatings 2019, 9, 652.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop