Next Article in Journal
Prescriber and Patient Responsibilities in Treatment of Acute Respiratory Tract Infections — Essential for Conservation of Antibiotics
Previous Article in Journal
Assessment of the Presence of Pharmaceutical Compounds in Seawater Samples from Coastal Area of Gran Canaria Island (Spain)
Previous Article in Special Issue
Phenotypic Resistance to Antibiotics
Open AccessReview

Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance

1
Institut Pasteur, Unité Plasticité du Génome Bactérien, Paris 75015, France
2
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3525, Paris 75015, France
*
Author to whom correspondence should be addressed.
Antibiotics 2013, 2(2), 288-315; https://doi.org/10.3390/antibiotics2020288
Received: 7 March 2013 / Revised: 21 May 2013 / Accepted: 23 May 2013 / Published: 30 May 2013
(This article belongs to the Special Issue Antibiotic Resistance)
The emergence of multi-resistant bacterial strains is a major source of concern and has been correlated with the widespread use of antibiotics. The origins of resistance are intensively studied and many mechanisms involved in resistance have been identified, such as exogenous gene acquisition by horizontal gene transfer (HGT), mutations in the targeted functions, and more recently, antibiotic tolerance through persistence. In this review, we focus on factors leading to integron rearrangements and gene capture facilitating antibiotic resistance acquisition, maintenance and spread. The role of stress responses, such as the SOS response, is discussed. View Full-Text
Keywords: integron; SOS; sub-MIC; reactive oxygen species; horizontal gene transfer; RpoS; CRP integron; SOS; sub-MIC; reactive oxygen species; horizontal gene transfer; RpoS; CRP
Show Figures

Figure 1

MDPI and ACS Style

Baharoglu, Z.; Garriss, G.; Mazel, D. Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance. Antibiotics 2013, 2, 288-315. https://doi.org/10.3390/antibiotics2020288

AMA Style

Baharoglu Z, Garriss G, Mazel D. Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance. Antibiotics. 2013; 2(2):288-315. https://doi.org/10.3390/antibiotics2020288

Chicago/Turabian Style

Baharoglu, Zeynep; Garriss, Geneviève; Mazel, Didier. 2013. "Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance" Antibiotics 2, no. 2: 288-315. https://doi.org/10.3390/antibiotics2020288

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop