Label-Free Bound-States-in-the-Continuum Biosensors
Abstract
:1. Introduction
2. Mechanism of BICs and Quasi-BICs
3. Performance Characteristics of Label-Free BICs Optical Biosensors
3.1. Bulk RI Sensitivity
3.2. Surface RI Sensitivity
3.3. Figure of Merit
3.4. Detection Limit
4. Label-Free BICs Optical Biosensors Based on Different Materials and Structures
4.1. All-Dielectric BICs
4.2. Metallic BICs
4.3. Hybrid Metal-Dielectric BICs
5. Summary and Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
- Spackova, B.; Wrobel, P.; Bockova, M.; Homola, J. Optical Biosensors Based on Plasmonic Nanostructures: A Review. Proc. IEEE 2016, 104, 2380–2408. [Google Scholar] [CrossRef]
- Inan, H.; Poyraz, M.; Inci, F.; Lifson, M.A.; Baday, M.; Cunningham, B.T.; Demirci, U. Photonic crystals: Emerging biosensors and their promise for point-of-care applications. Chem. Soc. Rev. 2017, 46, 366–388. [Google Scholar] [CrossRef] [Green Version]
- Altug, H.; Oh, S.H.; Maier, S.A.; Homola, J. Advances and applications of nanophotonic biosensors. Nat. Nanotechnol. 2022, 17, 5–16. [Google Scholar] [CrossRef] [PubMed]
- Yang, Y.; Peng, C.; Liang, Y.; Li, Z.B.; Noda, S. Analytical Perspective for Bound States in the Continuum in Photonic Crystal Slabs. Phys. Rev. Lett. 2014, 113, 037401. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zhuo, Y.; Hu, H.; Chen, W.L.; Lu, M.; Tian, L.M.; Yu, H.J.; Long, K.D.; Chow, E.; King, W.P.; Singamaneni, S.; et al. Single nanoparticle detection using photonic crystal enhanced microscopy. Analyst 2014, 139, 1007–1015. [Google Scholar] [CrossRef] [PubMed]
- Luan, E.X.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. Sensors 2018, 18, 3519. [Google Scholar] [CrossRef] [Green Version]
- Karmakar, S.; Kumar, D.; Varshney, R.K.; Chowdhury, D.R. Strong terahertz matter interaction induced ultrasensitive sensing in Fano cavity based stacked metamaterials. J. Phys. D Appl. Phys. 2020, 53, 415101. [Google Scholar] [CrossRef]
- Xu, Y.; Bai, P.; Zhou, X.D.; Akimov, Y.; Png, C.E.; Ang, L.K.; Knoll, W.; Wu, L. Optical Refractive Index Sensors with Plasmonic and Photonic Structures: Promising and Inconvenient Truth. Adv. Opt. Mater. 2019, 7, 1801433. [Google Scholar] [CrossRef]
- Kazanskiy, N.L.; Khonina, S.N.; Butt, M.A. Plasmonic sensors based on Metal-insulator-metal waveguides for refractive index sensing applications: A brief review. Physica E 2020, 117, 113798. [Google Scholar] [CrossRef]
- Liu, J.J.; Jalali, M.; Mahshid, S.; Wachsmann-Hogiu, S. Are plasmonic optical biosensors ready for use in point-of-need applications? Analyst 2020, 145, 364–384. [Google Scholar] [CrossRef]
- Pitruzzello, G.; Krauss, T.F. Photonic crystal resonances for sensing and imaging. J. Opt. 2018, 20, 073004. [Google Scholar] [CrossRef]
- Conteduca, D.; Barth, I.; Pitruzzello, G.; Reardon, C.P.; Martins, E.R.; Krauss, T.F. Dielectric nanohole array metasurface for high-resolution near-field sensing and imaging. Nat. Commun. 2021, 12, 3293. [Google Scholar] [CrossRef]
- Triggs, G.J.; Wang, Y.; Reardon, C.P.; Fischer, M.; Evans, G.J.O.; Krauss, T.F. Chirped guided-mode resonance biosensor. Optica 2017, 4, 229–234. [Google Scholar] [CrossRef]
- Kenaan, A.; Li, K.Z.; Barth, I.; Johnson, S.; Song, J.; Krauss, T.F. Guided mode resonance sensor for the parallel detection of multiple protein biomarkers in human urine with high sensitivity. Biosens. Bioelectron. 2020, 153, 112047. [Google Scholar] [CrossRef]
- Cetin, A.E.; Altug, H. Fano Resonant Ring/Disk Plasmonic Nanocavities on Conducting Substrates for Advanced Biosensing. ACS Nano 2012, 6, 9989–9995. [Google Scholar] [CrossRef]
- Zhang, Q.; Wen, X.L.; Li, G.Y.; Ruan, Q.F.; Wang, J.F.; Xiong, Q.H. Multiple Magnetic Mode-Based Fano Resonance in Split-Ring Resonator/Disk Nanocavities. ACS Nano 2013, 7, 11071–11078. [Google Scholar] [CrossRef]
- Cetin, A.E.; Etezadi, D.; Galarreta, B.C.; Busson, M.P.; Eksioglu, Y.; Altug, H. Plasmonic Nanohole Arrays on a Robust Hybrid Substrate for Highly Sensitive Label-Free Biosensing. ACS Photonics 2015, 2, 1167–1174. [Google Scholar] [CrossRef]
- Arora, P.; Talker, E.; Mazurski, N.; Levy, U. Dispersion engineering with plasmonic nano structures for enhanced surface plasmon resonance sensing. Sci. Rep. 2018, 8, 9060. [Google Scholar] [CrossRef] [Green Version]
- Kabashin, A.V.; Evans, P.; Pastkovsky, S.; Hendren, W.; Wurtz, G.A.; Atkinson, R.; Pollard, R.; Podolskiy, V.A.; Zayats, A.V. Plasmonic nanorod metamaterials for biosensing. Nat. Mater. 2009, 8, 867–871. [Google Scholar] [CrossRef]
- Ge, C.; Lu, M.; George, S.; Flood, T.A.; Wagner, C.; Zheng, J.; Pokhriyal, A.; Eden, J.G.; Hergenrother, P.J.; Cunningham, B.T. External cavity laser biosensor. Lab Chip 2013, 13, 1247–1256. [Google Scholar] [CrossRef]
- Zhou, Y.; Wang, B.W.; Guo, Z.H.; Wu, X. Guided Mode Resonance Sensors with Optimized Figure of Merit. Nanomaterials 2019, 9, 837. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ciminelli, C.; Campanella, C.M.; Dell’Olio, F.; Campanella, C.E.; Armenise, M.N. Label-free optical resonant sensors for biochemical applications. Prog. Quantum Electron. 2013, 37, 51–107. [Google Scholar] [CrossRef]
- Zhou, X.Y.; Zhang, L.; Armani, A.M.; Zhang, D.H.; Duan, X.X.; Liu, J.; Zhang, H.; Pang, W. On-Chip Biological and Chemical Sensing With Reversed Fano Lineshape Enabled by Embedded Microring Resonators. IEEE J. Sel. Top. Quantum 2014, 20, 5200110. [Google Scholar]
- Liao, J.; Wu, X.; Liu, L.Y.; Xu, L. Fano resonance and improved sensing performance in a spectral-simplified optofluidic micro-bubble resonator by introducing selective modal losses. Opt. Express 2016, 24, 8574–8580. [Google Scholar] [CrossRef] [PubMed]
- Yu, Z.J.; Xi, X.; Ma, J.W.; Tsang, H.K.; Zou, C.L.; Sun, X.K. Photonic integrated circuits with bound states in the continuum. Optica 2019, 6, 1342–1348. [Google Scholar] [CrossRef]
- Qin, H.Y.; Shi, X.D.; Ou, H.Y. Exceptional points at bound states in the continuum in photonic integrated circuits. Nanophotonics 2022. [Google Scholar] [CrossRef]
- Hsu, C.W.; Zhen, B.; Stone, A.D.; Joannopoulos, J.D.; Soljacic, M. Bound states in the continuum. Nat. Rev. Mater. 2016, 1, 16048. [Google Scholar] [CrossRef] [Green Version]
- Koshelev, K.; Bogdanov, A.; Kivshar, Y. Meta-optics and bound states in the continuum. Sci. Bull. 2019, 64, 836–842. [Google Scholar] [CrossRef] [Green Version]
- Koshelev, K.; Bogdanov, A.; Kivshar, Y. Engineering with Bound States in the Continuum. Opt. Photonics News 2020, 31, 38–45. [Google Scholar] [CrossRef]
- Azzam, S.I.; Kildishev, A.V. Photonic Bound States in the Continuum: From Basics to Applications. Adv. Opt. Mater. 2021, 9, 2001469. [Google Scholar] [CrossRef]
- Joseph, S.; Pandey, S.; Sarkar, S.; Joseph, J. Bound states in the continuum in resonant nanostructures: An overview of engineered materials for tailored applications. Nanophotonics 2021, 10, 4175–4207. [Google Scholar] [CrossRef]
- Chai, R.H.; Liu, W.W.; Cheng, H.; Tian, J.G.; Chen, S.Q. Bound States of Continuumin Optical Artificial Micro-Nanostructures: Fundamentals Developments and Applications. Acta Opt. Sin. 2021, 41, 0123001. [Google Scholar] [CrossRef]
- von Neumann, J.; Wigner, E. Concerning the behaviour of eigenvalues in adiabatic processes. Physica Z 1929, 30, 467–470. [Google Scholar]
- Marinica, D.C.; Borisov, A.G.; Shabanov, S.V. Bound states in the continuum in photonics. Phys. Rev. Lett. 2008, 100, 183902. [Google Scholar] [CrossRef]
- Plotnik, Y.; Peleg, O.; Dreisow, F.; Heinrich, M.; Nolte, S.; Szameit, A.; Segev, M. Experimental Observation of Optical Bound States in the Continuum. Phys. Rev. Lett. 2011, 107, 183902. [Google Scholar] [CrossRef] [Green Version]
- Yoon, J.W.; Song, S.H.; Magnusson, R. Critical field enhancement of asymptotic optical bound states in the continuum. Sci. Rep. 2015, 5, 18301. [Google Scholar] [CrossRef] [Green Version]
- Cong, L.Q.; Singh, R. Symmetry-Protected Dual Bound States in the Continuum in Metamaterials. Adv. Opt. Mater. 2019, 7, 1900383. [Google Scholar] [CrossRef]
- Friedrich, H.; Wintgen, D. Interfering Resonances and Bound-States in the Continuum. Phys. Rev. A 1985, 32, 3231–3242. [Google Scholar] [CrossRef]
- Hsu, C.W.; Zhen, B.; Lee, J.; Chua, S.L.; Johnson, S.G.; Joannopoulos, J.D.; Soljacic, M. Observation of trapped light within the radiation continuum. Nature 2013, 499, 188–191. [Google Scholar] [CrossRef] [Green Version]
- Azzam, S.I.; Shalaev, V.M.; Boltasseva, A.; Kildishev, A.V. Formation of Bound States in the Continuum in Hybrid Plasmonic-Photonic Systems. Phys. Rev. Lett. 2018, 121, 253901. [Google Scholar] [CrossRef] [Green Version]
- Longhi, S. Bound states in the continuum in a single-level Fano-Anderson model. Eur. Phys. J. B 2007, 57, 45–51. [Google Scholar] [CrossRef]
- Weimann, S.; Xu, Y.; Keil, R.; Miroshnichenko, A.E.; Tunnermann, A.; Nolte, S.; Sukhorukov, A.A.; Szameit, A.; Kivshar, Y.S. Compact Surface Fano States Embedded in the Continuum of Waveguide Arrays. Phys. Rev. Lett. 2013, 111, 240403. [Google Scholar] [CrossRef] [PubMed]
- Rybin, M.V.; Koshelev, K.L.; Sadrieva, Z.F.; Samusev, K.B.; Bogdanov, A.A.; Limonov, M.F.; Kivshar, Y.S. High-Q Supercavity Modes in Subwavelength Dielectric Resonators. Phys. Rev. Lett. 2017, 119, 243901. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Koshelev, K.; Lepeshov, S.; Liu, M.K.; Bogdanov, A.; Kivshar, Y. Asymmetric Metasurfaces with High-Q Resonances Governed by Bound States in the Continuum. Phys. Rev. Lett. 2018, 121, 193903. [Google Scholar] [CrossRef] [Green Version]
- Bogdanov, A.A.; Koshelev, K.L.; Kapitanova, P.V.; Rybin, M.V.; Gladyshev, S.A.; Sadrieva, Z.F.; Samusev, K.B.; Kivshar, Y.S.; Limonov, M.F. Bound states in the continuum and Fano resonances in the strong mode coupling regime. Adv. Photonics 2019, 1, 016001. [Google Scholar] [CrossRef] [Green Version]
- Chen, W.J.; Chen, Y.T.; Liu, W. Multipolar Conversion Induced Subwavelength High-Q Kerker Supermodes with Unidirectional Radiations. Laser Photonics Rev. 2019, 13, 1900067. [Google Scholar] [CrossRef]
- Lu, X.Y.; Zhang, T.Y.; Wan, R.G.; Xu, Y.T.; Zhao, C.H.; Guo, S. Numerical investigation of narrowband infrared absorber and sensor based on dielectric-metal metasurface. Opt. Express 2018, 26, 10179–10187. [Google Scholar] [CrossRef]
- Zhang, C.R.; Zhou, Y.; Mi, L.; Ma, J.; Wu, X.; Fei, Y.Y. High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating. Biosensors 2021, 11, 221. [Google Scholar] [CrossRef]
- Lu, H.; Huang, M.; Kang, X.B.; Liu, W.X.; Dong, C.; Zhang, J.; Xia, S.Q.; Zhang, X.Z. Improving the sensitivity of compound waveguide grating biosensor via modulated wavevector. Appl. Phys. Express 2018, 11, 082202. [Google Scholar] [CrossRef]
- White, I.M.; Fan, X.D. On the performance quantification of resonant refractive index sensors. Opt. Express 2008, 16, 1020–1028. [Google Scholar] [CrossRef] [Green Version]
- Zhang, Y.N.; Zhao, Y.; Lv, R.Q. A review for optical sensors based on photonic crystal cavities. Sens. Actuat A Phys. 2015, 233, 374–389. [Google Scholar] [CrossRef] [Green Version]
- Nicolaou, C.; Lau, W.T.; Gad, R.; Akhavan, H.; Schilling, R.; Levi, O. Enhanced detection limit by dark mode perturbation in 2D photonic crystal slab refractive index sensors. Opt. Express 2013, 21, 31698–31712. [Google Scholar] [CrossRef]
- Yang, Y.M.; Kravchenko, I.I.; Briggs, D.P.; Valentine, J. All-dielectric metasurface analogue of electromagnetically induced transparency. Nat. Commun. 2014, 5, 5753. [Google Scholar] [CrossRef] [Green Version]
- He, F.Y.; Liu, J.J.; Pan, G.M.; Shu, F.Z.; Jing, X.F.; Hong, Z. Analogue of Electromagnetically Induced Transparency in an All-Dielectric Double-Layer Metasurface Based on Bound States in the Continuum. Nanomaterials 2021, 11, 2343. [Google Scholar] [CrossRef]
- Algorri, J.F.; Dell’Olio, F.; Roldan-Varona, P.; Rodriguez-Cobo, L.; Lopez-Higuera, J.M.; Sanchez-Pena, J.M.; Dmitriev, V.; Zografopoulos, D.C. Analogue of electromagnetically induced transparency in square slotted silicon metasurfaces supporting bound states in the continuum. Opt. Express 2022, 30, 4615–4630. [Google Scholar] [CrossRef]
- Liu, Y.H.; Wang, S.L.; Zhao, D.Y.; Zhou, W.D.; Sun, Y.Z. High quality factor photonic crystal filter at k approximate to 0 and its application for refractive index sensing. Opt. Express 2017, 25, 10536–10545. [Google Scholar] [CrossRef] [Green Version]
- Liu, C.B.; Bai, Y.; Zhou, J.; Chen, J.H.; Qiao, L.J. Refractive index sensing by asymmetric dielectric gratings with both bound states in the continuum and guided mode resonances. Opt. Express 2021, 29, 42978–42988. [Google Scholar] [CrossRef]
- Shi, C.Y.; Liu, X.H.; Hu, J.H.; Han, H.Y.; Zhao, J.J. High performance optical sensor based on double compound symmetric gratings. Chin. Opt. Lett. 2022, 20, 021201. [Google Scholar] [CrossRef]
- Wang, Q.; Jiang, J.X.; Wang, L.; Yin, X.Y.; Yan, X.; Zhu, A.S.; Qiu, F.M.; Zhang, K.K. An asymmetric grating refractive index sensor generating quasi-bound states in the continuum with high figure of merit and temperature self-compensation. J. Phys. D Appl. Phys. 2022, 55, 155103. [Google Scholar] [CrossRef]
- Maksimov, D.N.; Gerasimov, V.S.; Romano, S.; Polyutov, S.P. Refractive index sensing with optical bound states in the continuum. Opt. Express 2020, 28, 38907–38916. [Google Scholar] [CrossRef]
- Maksimov, D.N.; Gerasimov, V.S.; Bogdanov, A.A.; Polyutov, S.P. Enhanced sensitivity of an all-dielectric refractive index sensor with an optical bound state in the continuum. Phys. Rev. A 2022, 105, 033518. [Google Scholar] [CrossRef]
- Mesli, S.; Yala, H.; Hamidi, M.; BelKhir, A.; Baida, F.I. High performance for refractive index sensors via symmetry-protected guided mode resonance. Opt. Express 2021, 29, 21199–21211. [Google Scholar] [CrossRef] [PubMed]
- Zhao, J.; Wang, J.X.; Lai, L.P.; Su, Q.Q.; Qiu, W.B.; Zhuo, L.Q. High-Q Dual-Band Terahertz Sensor Based on All-Dielectric Metasurface. Laser Optoelectron. Prog. 2022, 59, 5. [Google Scholar]
- Yesilkoy, F.; Arvelo, E.R.; Jahani, Y.; Liu, M.K.; Tittl, A.; Cevher, V.; Kivshar, Y.; Altug, H. Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces. Nat. Photonics 2019, 13, 390. [Google Scholar] [CrossRef] [Green Version]
- Jahani, Y.; Arvelo, E.R.; Yesilkoy, F.; Koshelev, K.; Cianciaruso, C.; De Palma, M.; Kivshar, Y.; Altug, H. Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles. Nat. Commun. 2021, 12, 3246. [Google Scholar] [CrossRef]
- Kuhner, L.; Sortino, L.; Berte, R.; Wang, J.; Ren, H.; Maier, S.A.; Kivshar, Y.; Tittl, A. Radial bound states in the continuum for polarization-invariant nanophotonics. Nat. Commun. 2022, 13, 4992. [Google Scholar] [CrossRef]
- Wang, J.; Kuhne, J.; Karamanos, T.; Rockstuhl, C.; Maier, S.A.; Tittl, A. All-Dielectric Crescent Metasurface Sensor Driven by Bound States in the Continuum. Adv. Funct. Mater. 2021, 31, 2104652. [Google Scholar] [CrossRef]
- Ndao, A.; Hsu, L.Y.; Cai, W.; Ha, J.H.; Park, J.; Contractor, R.; Lo, Y.W.; Kant, B. Differentiating and quantifying exosome secretion from a single cell using quasi-bound states in the continuum. Nanophotonics 2020, 9, 1081–1086. [Google Scholar] [CrossRef] [Green Version]
- Wang, Y.; Ali, M.A.; Chow, E.K.C.; Dong, L.; Lu, M. An optofluidic metasurface for lateral flow-through detection of breast cancer biomarker. Biosens. Bioelectron. 2018, 107, 224–229. [Google Scholar] [CrossRef]
- Li, B.; Yao, J.; Zhu, H.; Cai, G.X.; Liu, Q.H. Asymmetric excitations of toroidal dipole resonance and the magnetic dipole quasi-bound state in the continuum in an all-dielectric metasurface. Opt. Mater. Express 2021, 11, 2359–2368. [Google Scholar] [CrossRef]
- Yang, L.; Yu, S.L.; Li, H.; Zhao, T.G. Multiple Fano resonances excitation on all-dielectric nanohole arrays metasurfaces. Opt. Express 2021, 29, 14905–14916. [Google Scholar] [CrossRef]
- Huo, Y.Y.; Zhang, X.; Yan, M.; Sun, K.; Jiang, S.Z.; Ning, T.Y.; Zhao, L.N. Highly-sensitive sensor based on toroidal dipole governed by bound state in the continuum in dielectric non-coaxial core-shell cylinder. Opt. Express 2022, 30, 19030–19041. [Google Scholar] [CrossRef]
- Li, Z.F.; Xiang, Y.J.; Xu, S.X.; Dai, X.Y. Ultrasensitive terahertz sensing in all-dielectric asymmetric metasurfaces based on quasi-BIC. J. Opt. Soc. Am. B 2022, 39, 286–291. [Google Scholar] [CrossRef]
- Samadi, M.; Abshari, F.; Algorri, J.F.; Roldan-Varona, P.; Rodriguez-Cobo, L.; Lopez-Higuera, J.M.; Sanchez-Pena, J.M.; Zografopoulos, D.C.; Dell’Olio, F. All-Dielectric Metasurface Based on Complementary Split-Ring Resonators for Refractive Index Sensing. Photonics 2022, 9, 130. [Google Scholar] [CrossRef]
- Wang, Y.S.; Yu, S.L.; Gao, Z.A.; Song, S.Z.; Li, H.Y.; Zhao, T.G.; Hu, Z.H. Excitations of Multiple Fano Resonances Based on Permittivity-Asymmetric Dielectric Meta-Surfaces for Nano-Sensors. IEEE Photonics J. 2022, 14, 4613107. [Google Scholar] [CrossRef]
- Yu, S.L.; Li, H.; Wang, Y.S.; Gao, Z.; Zhao, T.G.; Yu, J.G. Multiple Fano resonance excitation of all-dielectric nanoholes cuboid arrays in near infrared region. Results Phys. 2021, 28, 104569. [Google Scholar] [CrossRef]
- Hsiao, H.H.; Hsu, Y.C.; Liu, A.Y.; Hsieh, J.C.; Lin, Y.H. Ultrasensitive Refractive Index Sensing Based on the Quasi-Bound States in the Continuum of All-Dielectric Metasurfaces. Adv. Opt. Mater. 2022, 10, 2200812. [Google Scholar] [CrossRef]
- Gu, Z.D.; Chen, J.X.; Gao, B.F.; Wu, W.; Zhao, Z.Y.; Cai, W.; Zhang, X.Z.; Ren, M.X.; Xu, J.J. Metasurfaces with high-Q resonances governed by topological edge state. Opt. Lett. 2022, 47, 1822–1825. [Google Scholar] [CrossRef]
- Chao, M.H.; Liu, Q.S.; Zhang, W.J.; Zhuang, L.Y.; Song, G.F. Mutual coupling of corner-localized quasi-BICs in high-order topological PhCs and sensing applications. Opt. Express 2022, 30, 29258–29270. [Google Scholar] [CrossRef]
- Romano, S.; Lamberti, A.; Masullo, M.; Penzo, E.; Cabrini, S.; Rendina, I.; Mocella, V. Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum. Materials 2018, 11, 526. [Google Scholar] [CrossRef] [Green Version]
- Romano, S.; Zito, G.; Torino, S.; Calafiore, G.; Penzo, E.; Coppola, G.; Cabrini, S.; Rendina, I.; Mocella, V. Label-free sensing of ultralow-weight molecules with all-dielectric metasurfaces supporting bound states in the continuum. Photonics Res. 2018, 6, 726–733. [Google Scholar] [CrossRef]
- Romano, S.; Zito, G.; Yepez, S.N.L.; Cabrini, S.; Penzo, E.; Coppola, G.; Rendina, I.; Mocella, V. Tuning the exponential sensitivity of a bound-state-in-continuum optical sensor. Opt. Express 2019, 27, 18776–18786. [Google Scholar] [CrossRef] [PubMed]
- Zito, G.; Sanita, G.; Alulema, B.G.; Yepez, S.N.L.; Lanzio, V.; Riminucci, F.; Cabrini, S.; Moccia, M.; Avitabile, C.; Lamberti, A.; et al. Label-free DNA biosensing by topological light confinement. Nanophotonics 2021, 10, 4279–4287. [Google Scholar] [CrossRef]
- Liu, Y.H.; Zhou, W.D.; Sun, Y.Z. Optical Refractive Index Sensing Based on High-Q Bound States in the Continuum in Free-Space Coupled Photonic Crystal Slabs. Sensors 2017, 17, 1861. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lv, J.X.; Chen, Z.H.; Yin, X.F.; Zhang, Z.X.; Hu, W.W.; Peng, C. High-Sensitive Refractive Index Sensing Enabled by Topological Charge Evolution. IEEE Photonics J. 2020, 12, 4501610. [Google Scholar] [CrossRef]
- Wang, Z.; Xue, Q.; Zhao, S.L.; Zhang, X.R.; Liu, H.M.; Sun, X.H. Study on the characteristics of a photonic crystal sensor with rectangular lattice based on bound states in the continuum. J. Phys. D Appl. Phys. 2022, 55, 175106. [Google Scholar] [CrossRef]
- Hemmati, H.; Magnusson, R. Resonant Dual-Grating Metamembranes Supporting Spectrally Narrow Bound States in the Continuum. Adv. Opt. Mater. 2019, 7, 1900754. [Google Scholar] [CrossRef]
- Qin, J.; Jiang, S.B.; Wang, Z.S.; Cheng, X.B.; Li, B.J.; Shi, Y.Z.; Tsai, D.P.; Liu, A.Q.; Huang, W.; Zhu, W.M. Metasurface Micro/Nano-Optical Sensors: Principles and Applications. ACS Nano 2022, 16, 11598–11618. [Google Scholar] [CrossRef]
- Zhang, S.Y.; Wong, C.L.; Zeng, S.W.; Bi, R.Z.; Tai, K.; Dholakia, K.; Olivo, M. Metasurfaces for biomedical applications: Imaging and sensing from a nanophotonics perspective. Nanophotonics 2021, 10, 259–293. [Google Scholar] [CrossRef]
- Shi, Q.; Zhao, J.L.; Liang, L.J. Two dimensional photonic crystal slab biosensors using label free refractometric sensing schemes: A review. Prog. Quantum Electron. 2021, 77, 100298. [Google Scholar] [CrossRef]
- Romano, S.; Mangini, M.; Penzo, E.; Cabrini, S.; De Luca, A.C.; Rendina, I.; Mocella, V.; Zito, G.L.G. Ultrasensitive Surface Refractive Index Imaging Based on Quasi-Bound States in the Continuum. ACS Nano 2020, 14, 15417–15427. [Google Scholar] [CrossRef]
- Wang, Z.B.; Chen, J.J.; Khan, S.A.; Li, F.J.; Shen, J.Q.; Duan, Q.L.; Liu, X.Y.; Zhu, J.F. Plasmonic Metasurfaces for Medical Diagnosis Applications: A Review. Sensors 2022, 22, 133. [Google Scholar] [CrossRef]
- Srivastava, Y.K.; Ako, R.T.; Gupta, M.; Bhaskaran, M.; Sriram, S.; Singh, R. Terahertz sensing of 7 nm dielectric film with bound states in the continuum metasurfaces. Appl. Phys. Lett. 2019, 115, 151105. [Google Scholar] [CrossRef]
- Tan, T.C.; Srivastava, Y.K.; Ako, R.T.; Wang, W.H.; Bhaskaran, M.; Sriram, S.; Al–Naib, I.; Plum, E.; Singh, R. Active Control of Nanodielectric-Induced THz Quasi-BIC in Flexible Metasurfaces: A Platform for Modulation and Sensing. Adv. Mater. 2021, 33, 2100836. [Google Scholar] [CrossRef]
- Wang, R.; Xu, L.; Wang, J.Y.; Sun, L.; Jiao, Y.N.; Meng, Y.; Chen, S.; Chang, C.; Fan, C.H. Electric Fano resonance-based terahertz metasensors. Nanoscale 2021, 13, 18467–18472. [Google Scholar] [CrossRef]
- Chen, X.; Fan, W.H.; Jiang, X.Q.; Yan, H. High-Q Toroidal Dipole Metasurfaces Driven By Bound States in the Continuum for Ultrasensitive Terahertz Sensing. J. Lightwave Technol. 2022, 40, 2181–2190. [Google Scholar] [CrossRef]
- Hu, Y.L.; Xie, S.X.; Bai, C.J.; Shen, W.W.; Yang, J.C. Quasi-Bound States in the Continuum Enabled Strong Terahertz Chiroptical Response in Bilayer Metallic Metasurfaces. Crystals 2022, 12, 1052. [Google Scholar] [CrossRef]
- Cen, W.Y.; Lang, T.T.; Hong, Z.; Liu, J.J.; Xiao, M.Y.; Zhang, J.H.; Yu, Z.Y. Ultrasensitive Flexible Terahertz Plasmonic Metasurface Sensor Based on Bound States in the Continuum. IEEE Sens. J. 2022, 22, 12838–12845. [Google Scholar] [CrossRef]
- Zhou, Y.; Guo, Z.H.; Zhao, X.Y.; Wang, F.L.; Yu, Z.Y.; Chen, Y.Z.; Liu, Z.R.; Zhang, S.Y.; Sun, S.L.; Wu, X. Dual-Quasi Bound States in the Continuum Enabled Plasmonic Metasurfaces. Adv. Opt. Mater. 2022, 10, 2200965. [Google Scholar] [CrossRef]
- Sarkar, S.; Gupta, V.; Kumar, M.; Schubert, J.; Probst, P.T.; Joseph, J.; Konig, T.A.F. Hybridized Guided-Mode Resonances via Colloidal Plasmonic Self-Assembled Grating. ACS Appl. Mater. Interfaces 2019, 11, 13752–13760. [Google Scholar] [CrossRef] [Green Version]
- Meudt, M.; Bogiadzi, C.; Wrobel, K.; Gorrn, P. Hybrid Photonic-Plasmonic Bound States in Continuum for Enhanced Light Manipulation. Adv. Opt. Mater. 2020, 8, 2000898. [Google Scholar] [CrossRef]
- Chen, H.R.; Wang, H.F.; Wong, K.Y.; Lei, D.Y. High-Q localized surface plasmon resonance based on bound states in the continuum for enhanced refractive index sensing. Opt. Lett. 2022, 47, 609–612. [Google Scholar] [CrossRef] [PubMed]
- Tang, S.L.; Chang, C.; Zhou, P.J.; Zou, Y. Numerical Study on a Bound State in the Continuum Assisted Plasmonic Refractive Index Sensor. Photonics 2022, 9, 224. [Google Scholar] [CrossRef]
- Wang, J.; Yang, J.Z.; Zhao, H.W.; Chen, M. Quasi-BIC-governed light absorption of monolayer transition-metal dichalcogenide-based absorber and its sensing performance. J. Phys. D Appl. Phys. 2021, 54, 485106. [Google Scholar] [CrossRef]
- Liu, X.Y.; Li, F.Y.; Li, Y.X.; Tang, T.T.; Liao, Y.L.; Lu, Y.C.; Wen, Q.Y. Terahertz metasurfaces based on bound states in the continuum (BIC) for high-sensitivity refractive index sensing. Optik 2022, 261, 169248. [Google Scholar] [CrossRef]
- Liu, W.Y.; Li, W.; Liu, C.X.; Xing, E.B.; Zhou, Y.R.; Liu, L.; Shi, Y.B.; Tang, J. All-Optical Tuning of Fano Resonance for Quasi-BIC and Terahertz Sensing Applications. Appl. Sci. 2022, 12, 4207. [Google Scholar] [CrossRef]
- Joseph, S.; Sarkar, S.; Joseph, J. Grating-Coupled Surface Plasmon-Polariton Sensing at a Flat Metal-Analyte Interface in a Hybrid-Configuration. ACS Appl. Mater. Interfaces 2020, 12, 46519–46529. [Google Scholar] [CrossRef]
- Joseph, S.; Sarkar, S.; Khan, S.; Joseph, J. Exploring the Optical Bound State in the Continuum in a Dielectric Grating Coupled Plasmonic Hybrid System. Adv. Opt. Mater. 2021, 9, 2001895. [Google Scholar] [CrossRef]
Structure | Analyte | Q Factor | Bulk Sensitivity (nm/RIU) | FOM (RIU−1) | DL/LOD | Ref. |
---|---|---|---|---|---|---|
All-Dielectric Gratings | 345 | 2622 | [49] | |||
441 | 1506 | ~5000 | [57] | |||
472 | 31,467 | [58] | ||||
369.43 | 3212.43 | 1.56 × 10−5 RIU | [59] | |||
3 × 106 | 656 | 1.64 × 106 | [62] | |||
12,620 | 31,394 | 1000 | [63] | |||
All-Dielectric Metasurfaces | Oil | 483 | 379 | 103 | [53] | |
M-IgG | 144 | 263 | <3 molecules/µm2 | [64] | ||
Nanoparticles; EVs | 178.6 | 305 | 68 | 0.41 molecules/µm2; 133 femtomolar | [65] | |
Biotin-streptavidin | 120 | 326 | 0.167 nM | [67] | ||
Exosomes | 750 | 440 | 677 | [68] | ||
Biotin-streptavidin | 500 | 20 | [66] | |||
ErbB2 | 900 | 720 | 0.7 ng/L | [69] | ||
17,684 | 630 | [70] | ||||
3.15 × 104 | 295 | 738 | [71] | |||
342 | 1295 | [72] | ||||
20,561 | 170.58 (GHz/RIU) | [73] | ||||
155 | 387,500 | [74] | ||||
14,437 | 394 | 4925 | [75] | |||
2617 | 300 | 440 | [76] | |||
SOG, PMMA-A4, ZEP520A | ~102 | 608 | 46 | [77] | ||
1045 | 100 | 145 | [78] | |||
All-Dielectric PhCSs | Cargille RI liquids | 10,643 | 832 | ~10−8 RIU | [52] | |
Ethanol/DI | 3.2 × 104 | 94.5 | 3 × 10−5 RIU | [56] | ||
104~105 | 312.8 | ~103 | [79] | |||
p53-MDM2 | 760 | 66 nM | [80] | |||
All-Dielectric PhCSs | BPT/ethanol solution | 2000 | 178 | 445 | 186 Da | [81] |
Cargille RI liquids | 226 | 258 | 4 × 10−7 RIU | [82] | ||
PNA-DNA | ~102 | 0.05 nM | [83] | |||
Ethanol/DI | 1.2 × 104 | 94 | 6 × 10−5 RIU | [84] | ||
Cargille RI liquids | >7 × 104 | 36 | 5990 | ~10−5 RIU | [85] | |
25,643 | 148 | 821 | [86] | |||
PC3 cell | 905 | 102.6 | ~10−5 RIU | [91] | ||
Plasmonic Metasurfaces | D/A-IgG | 648 | 72 | [15] | ||
Glycerol/water | 282 | 4 | [16] | |||
Ge film | 0.28 (/RIU) | [93] | ||||
Ge film | 1.7 × 104 | [94] | ||||
IL-6 | 16 | 165 (GHz/RIU) | ~1 nM | [95] | ||
1016 | 775.7 (GHz/RIU) | 284 | [96] | |||
200 (GHz/RIU) | [97] | |||||
64 | 265.06 (GHz/RIU) | 9.1 | [98] | |||
DMSO/DI | 145 | 657 | 109 | [99] | ||
Hybrid Gratings | Air | 1300 | 334 | 1.43 × 105 | [101] | |
111 | ~500 | 100 | [102] | |||
Glucose solution | ~5000 | 1264 | 7022 | [103] | ||
Hybrid Metasurfaces | 157 | 15,570 | [104] | |||
≥250 | 11.1 (GHz/RIU) | [105] | ||||
1130 | 9.41 (GHz/RIU) | [106] |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Luo, M.; Zhou, Y.; Zhao, X.; Li, Y.; Guo, Z.; Yang, X.; Zhang, M.; Wang, Y.; Wu, X. Label-Free Bound-States-in-the-Continuum Biosensors. Biosensors 2022, 12, 1120. https://doi.org/10.3390/bios12121120
Luo M, Zhou Y, Zhao X, Li Y, Guo Z, Yang X, Zhang M, Wang Y, Wu X. Label-Free Bound-States-in-the-Continuum Biosensors. Biosensors. 2022; 12(12):1120. https://doi.org/10.3390/bios12121120
Chicago/Turabian StyleLuo, Man, Yi Zhou, Xuyang Zhao, Yuxiang Li, Zhihe Guo, Xi Yang, Meng Zhang, You Wang, and Xiang Wu. 2022. "Label-Free Bound-States-in-the-Continuum Biosensors" Biosensors 12, no. 12: 1120. https://doi.org/10.3390/bios12121120