Next Article in Journal
Point of Care Diagnostics in Resource-Limited Settings: A Review of the Present and Future of PoC in Its Most Needed Environment
Previous Article in Journal
One-Pot, In-Situ Synthesis of 8-Armed Poly(Ethylene Glycol)-Coated Ag Nanoclusters as a Fluorescent Sensor for Selective Detection of Cu2+
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Biosensors
Volume 10
Issue 10
10.3390/bios10100132
biosensors-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Communication

Tuning the Surface Charge of Self-Assembled Polydiacetylene Vesicles to Control Aggregation and Cell Binding

by
Anthony David Nelson
,
Priyanka Shiveshwarkar
,
Butaek Lim
,
Gumaro Rojas
,
Izele Abure
,
Anura Shrestha
and
Justyn Jaworski
*
Department of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA
*
Author to whom correspondence should be addressed.
Biosensors 2020, 10(10), 132; https://doi.org/10.3390/bios10100132
Received: 24 August 2020 / Revised: 18 September 2020 / Accepted: 21 September 2020 / Published: 24 September 2020
(This article belongs to the Section Biosensor Materials)
View Full-Text Download PDF
Browse Figures

Abstract

Polydiacetylene vesicles of various compositions were assembled using a two-part mixture of 10,12-pentacosadiynoic acid (PCDA) and ethylenedioxy-bis-ethylamine (EDEA)-labeled PCDA in order to control surface charge and stability within a desired pH range. Investigation of the interaction of the vesicles with mammalian cells as a function of surface charge was carried out and identified a clear correlation in cell–vesicle association and corresponding cell death for vesicles with positive surface charge. The binding behavior of the vesicles was found to be tunable by regulating the proportion of anionic PCDA relative to cationic PCDA–EDEA content within vesicles as to control the surface charge as a function of pH. Association of vesicles with cells thus depended on the corresponding charge of the vesicles and cell surface. The prospect of this work may serve as a step toward future vesicle designs to allow triggered uptake of vesicles locally within low pH tumor microenvironments. View Full-Text
Keywords: polydiacetylene; vesicles; surface charge; pH polydiacetylene; vesicles; surface charge; pH
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

David Nelson, A.; Shiveshwarkar, P.; Lim, B.; Rojas, G.; Abure, I.; Shrestha, A.; Jaworski, J. Tuning the Surface Charge of Self-Assembled Polydiacetylene Vesicles to Control Aggregation and Cell Binding. Biosensors 2020, 10, 132. https://doi.org/10.3390/bios10100132

AMA Style

David Nelson A, Shiveshwarkar P, Lim B, Rojas G, Abure I, Shrestha A, Jaworski J. Tuning the Surface Charge of Self-Assembled Polydiacetylene Vesicles to Control Aggregation and Cell Binding. Biosensors. 2020; 10(10):132. https://doi.org/10.3390/bios10100132

Chicago/Turabian Style

David Nelson, Anthony, Priyanka Shiveshwarkar, Butaek Lim, Gumaro Rojas, Izele Abure, Anura Shrestha, and Justyn Jaworski. 2020. "Tuning the Surface Charge of Self-Assembled Polydiacetylene Vesicles to Control Aggregation and Cell Binding" Biosensors 10, no. 10: 132. https://doi.org/10.3390/bios10100132

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop