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A Human-Relevant 3D In Vitro Platform for an Effective and Rapid Simulation of Workplace Exposure to Nanoparticles: Silica Nanoparticles as Case Study

1
Istituto Italiano di Tecnologia, Nanoregulatory Platform, Drug Discovery and Development Department, 16163 Genova, Italy
2
Italian Workers’ Compensation Authority (INAIL), Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monte Porzio Catone, 00078 Rome, Italy
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(9), 1761; https://doi.org/10.3390/nano10091761
Received: 5 August 2020 / Revised: 2 September 2020 / Accepted: 4 September 2020 / Published: 6 September 2020
In this contribution, we show the suitability of a 3D airway model, when coupled with a nebulizer system, for simulating workplace exposure to nanoparticles. As a proof of concept, workplace exposure to silica nanoparticles was experimentally measured in an occupational facility where nanoparticles are produced weekly, and compared with the official limit value for bulk silica materials. These values of potential exposure were simulated in a 3D airway model by nebulizing low doses (from 0.90 to 55 µg/cm2) of silica nanoparticles over a prolonged period (12 weeks of repeated exposure, 5 days per week). Overall, the results suggest the efficiency of the defense mechanisms of the respiratory system and the clearance of the breathed silica nanoparticles by the mucociliary apparatus in accordance with the recent in vivo data. This in vitro platform shows that the doses tested may correlate with the occupational exposure limit values. Such relationship could provide regulatory-oriented data useful for risk classification of nanomaterials. View Full-Text
Keywords: nanomaterial risk assessment; occupational exposure assessment; inhalation toxicity; aerosol system; silica nanoparticles nanomaterial risk assessment; occupational exposure assessment; inhalation toxicity; aerosol system; silica nanoparticles
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MDPI and ACS Style

Di Cristo, L.; Boccuni, F.; Iavicoli, S.; Sabella, S. A Human-Relevant 3D In Vitro Platform for an Effective and Rapid Simulation of Workplace Exposure to Nanoparticles: Silica Nanoparticles as Case Study. Nanomaterials 2020, 10, 1761. https://doi.org/10.3390/nano10091761

AMA Style

Di Cristo L, Boccuni F, Iavicoli S, Sabella S. A Human-Relevant 3D In Vitro Platform for an Effective and Rapid Simulation of Workplace Exposure to Nanoparticles: Silica Nanoparticles as Case Study. Nanomaterials. 2020; 10(9):1761. https://doi.org/10.3390/nano10091761

Chicago/Turabian Style

Di Cristo, Luisana; Boccuni, Fabio; Iavicoli, Sergio; Sabella, Stefania. 2020. "A Human-Relevant 3D In Vitro Platform for an Effective and Rapid Simulation of Workplace Exposure to Nanoparticles: Silica Nanoparticles as Case Study" Nanomaterials 10, no. 9: 1761. https://doi.org/10.3390/nano10091761

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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