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Article

Evaluation of Clinical Performance of TiNi-Based Implants Used in Chest Wall Repair after Resection for Malignant Tumors

1
Laboratory of Medical Materials, Tomsk State University, 634045 Tomsk, Russia
2
Department of Surgery, Siberian State Medical University, 634050 Tomsk, Russia
3
R&D Center, TiNiKo Co., Ochang 28119, Korea
4
Boramae Medical Center, Seoul National University Hospital, Seoul 07061, Korea
5
Department of Physical Metallurgy and Materials Technology, Brandenburg University of Technology, 03-046 Cottbus, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Cristian Scheau, Andreea Didilescu and Constantin Caruntu
J. Funct. Biomater. 2021, 12(4), 60; https://doi.org/10.3390/jfb12040060
Received: 8 October 2021 / Revised: 6 November 2021 / Accepted: 8 November 2021 / Published: 11 November 2021
(This article belongs to the Special Issue Medical Application of Functional Biomaterials)
In this study, we assessed the outcomes after surgical treatment of thoracic post-excision defects in 15 patients, using TiNi knitted surgical meshes and customized artificial TiNi-based ribs. Methods: Eight patients were diagnosed with advanced non-small cell lung cancer (NSCLC) invading the chest wall, of which five patients were T3N0M0, two were T3N1M0, and one was T3N2M0. Squamous cell carcinoma was identified in three of these patients and adenocarcinoma in five. In two cases, chest wall resection and repair were performed for metastases of kidney cancer after radical nephrectomy. Three-dimensional CT reconstruction and X-ray scans were used to plan the surgery and customize the reinforcing TiNi-based implants. All patients received TiNi-based devices and were prospectively followed for a few years. Results: So far, there have been no lethal outcomes, and all implanted devices were consistent in follow-up examinations. Immediate complications were noted in three cases (ejection of air through the pleural drains, paroxysm of atrial fibrillation, and pleuritis), which were conservatively managed. In the long term, no complications, aftereffects, or instability of the thoracic cage were observed. Conclusion: TiNi-based devices used for extensive thoracic lesion repair in this context are promising and reliable biomaterials that demonstrate good functional, clinical, and cosmetic outcomes. View Full-Text
Keywords: non-small cell lung cancer (NSCLC); thoracic lesion; chest wall reconstruction; TiNi artificial rib; TiNi mesh implant non-small cell lung cancer (NSCLC); thoracic lesion; chest wall reconstruction; TiNi artificial rib; TiNi mesh implant
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MDPI and ACS Style

Topolnitskiy, E.; Chekalkin, T.; Marchenko, E.; Yasenchuk, Y.; Kang, S.-B.; Kang, J.-H.; Obrosov, A. Evaluation of Clinical Performance of TiNi-Based Implants Used in Chest Wall Repair after Resection for Malignant Tumors. J. Funct. Biomater. 2021, 12, 60. https://doi.org/10.3390/jfb12040060

AMA Style

Topolnitskiy E, Chekalkin T, Marchenko E, Yasenchuk Y, Kang S-B, Kang J-H, Obrosov A. Evaluation of Clinical Performance of TiNi-Based Implants Used in Chest Wall Repair after Resection for Malignant Tumors. Journal of Functional Biomaterials. 2021; 12(4):60. https://doi.org/10.3390/jfb12040060

Chicago/Turabian Style

Topolnitskiy, Evgeniy, Timofey Chekalkin, Ekaterina Marchenko, Yuri Yasenchuk, Seung-Baik Kang, Ji-Hoon Kang, and Aleksei Obrosov. 2021. "Evaluation of Clinical Performance of TiNi-Based Implants Used in Chest Wall Repair after Resection for Malignant Tumors" Journal of Functional Biomaterials 12, no. 4: 60. https://doi.org/10.3390/jfb12040060

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