A New Generalized Definition of Fractional Derivative with Non-Singular Kernel

This paper proposes a new definition of fractional derivative with non-singular kernel in the sense of Caputo which generalizes various forms existing in the literature. Furthermore, the version in the sense of Riemann–Liouville is defined. Moreover, fundamental properties of the new generalized fractional derivatives in the sense of Caputo and Riemann–Liouville are rigorously studied. Finally, an application in epidemiology as well as in virology is presented.


Introduction
Fractional derivative is the generalization of the classical derivative of integer order. It has been recently used to study the impact of memory on the dynamics of various systems from different fields such as epidemiology [1,2], virology [3][4][5], ecology [6][7][8] and economics [9]. On the other hand, it has been shown that the membranes of cells of biological systems have a fractional-order electrical conductance [10]. Furthermore, the fractance is an electrical circuit with non-integer order impedance [11]. Additionally, fractional differential equations are currently used to model and solve a variety of biological and engineering problems [12][13][14][15][16][17].
In recent years, the definition of fractional derivative has drawn attention several researchers. In 2015, Caputo and Fabrizio [18] presented a new fractional derivative with non-singular kernel. In 2016, Atangana and Baleanu [19] remarked that the fractional derivative proposed in [18] cannot produce the original function when the order of derivative is equal to zero. To solve this problem, they proposed a new definition of fractional derivative based on Mittag-Lefler function. In 2020, Al-Refai [20] defined the weighted Atangana-Baleanu fractional derivative in a Caputo sense and he used the Laplace transform to solve an associated linear fractional differential equation.
The main purpose of this study is to propose a new definition of fractional derivative that generalizes the above mentioned fractional derivatives with non-singular kernel for both Caputo and Riemann-Liouville types. To do this, Section 2 is devoted to the definition for both types and some fundamental properties. The Laplace transform and fractional integral corresponding to new generalized derivative are given in Sections 3 and 4. Finally, an application is presented in the last section.

The New Fractional Derivative
In this section, we define our new fractional derivative and establish their properties.
Let H 1 (a, b) be the Sobolev space of order one defined as follows: The new generalized fractional derivative of order α of Caputo sense of the function f (t) with respect to the weight function w(t) is defined as follows: where w ∈ C 1 (a, b), w, w > 0 on [a,b], N(α) is a normalization function obeying N(0) = N(1) = 1, is the Mittag-Leffler function of parameter β.
It is very important to note that the above definition includes many special cases existing in the literature. For example,

3.
When β = γ = α, we obtain the weighted Atangana-Baleanu fractional derivative that recently defined in [20], and it is given by On the other hand, it is not hard to show that the new generalized fractional derivative of Caputo sense has the following properties: a,t,w g(t) holds for all scalars c 1 , c 2 and functions f , g ∈ H 1 (a, b). This implies that the new generalized fractional derivative is a linear operator.
From the last property, we observe that when the derivative order is equal to zero, we do not recover the original function, unless f (a) is null. To avoid this problem, we present the following new definition.
The new generalized fractional derivative of order α of Riemann-Liouville sense of the function f (t) with respect to the weight function w(t) is given by Equation (2) shows that the new generalized fractional derivative of Riemann-Liouville sense of zero order recovers the original function. Indeed, Furthermore, the new generalized fractional derivative in the sense of Riemann-Liouville is a linear operator. In fact, for all scalars c 1 , c 2 and functions f , Theorem 1. Let w f be an analytic function. Then Proof. Since w f is an analytic function, we have This completes the proof.

Laplace Transform of the New Derivative
In this section, we determine the Laplace transform of the generalized fractional derivative of both types, Caputo and Riemann-Liouville.
In particular, when γ = β, we have Proof. We have According to Lemma 1, we can easily get the following result.
Theorem 2. The Laplace transform of C D α,β,γ a,t,w is given by In particular, we have Further, the Laplace transform of R D α,β,γ a,t,w is given by In particular, we have Obviously, we have the following remark.

Fractional Integral Associated to the New Derivative
This section focuses on the definition of fractional integral corresponding to the new generalized derivative. Theorem 3. The following fractional differential equation: R D α,β,β 0,t,w y(t) = f (t) (10) has a unique solution given by Proof. We have w(t) R D α,β,β 0,t,w y(t) = w(t) f (t). By passage to Laplace transform and applying Theorem 2, we find The passage to the inverse Laplace leads to Definition 3. When γ = β, we define the generalized fractional integral corresponding to new fractional derivative as follows This generalized fractional integral coincides with the Atangana-Baleanu fractional integral when w(t) = 1 and γ = β = α, and with the weighted Atangana-Baleanu fractional integral defined by Al-Refai [20] when γ = β = α. Additionally, we recover the original function when α = 0 and also the ordinary integral when α = 1.
On the other hand, we have where which denotes the weighted Riemann-Liouville fractional integral of order α. Consequently, the generalized derivative in the sense of Riemann-Liouville can be represented by an infinite series whose general term contains the weighted Riemann-Liouville integral.

Application
Mathematical modeling in epidemiology has become an effective tool for understanding and describing the dynamics of infectious diseases. It currently used to predict the evolution of coronavirus disease 2019 (COVID-19) in many countries. The first epidemiological model was introduced by Ross [21,22] to study transmission of Malaria in early 1900. Based on Ross' ideas, Kermack and Mckendrick [23] presented a susceptible-infected-recovered (SIR) compartmental model in order to explain the evolution of the plague in island of Bombay over the period 17 December 1905 to 21 July 1906. This classical SIR model was extended by many researchers to describe other infectious diseases (see for example [24,25]). In this section, we consider the following model: where S(t), I(t) and R(t) are the number of susceptible, infected, and removed individuals at time t, respectively. The parameters A, µ, κ and r represent the recruitment rate, the natural death rate, the infection rate and the removal rate, respectively.
Let T(t) be the total population. Then T(t) = S(t) + I(t) + R(t) and Clearly, the solution of (16) is given by For simplicity, we denote C D In the following, we are interested to solve this last fractional differential equation which plays a significant role in epidemiology as well as in virology. In particular for human immunodeficiency virus (HIV) infection, T(t) can represent the concentration of healthy CD4 + T cells that are produced at rate A and die at rate µ.
Applying Laplace transform to (18), we obtain From Theorem 2, we have The passage to the inverse Laplace leads to By using integration by parts, we have Therefore, Remark 2.
Now, we study numerically the impact of the order of new fractional derivative on the dynamics behavior of the solution given by (20). For the case of HIV infection, we choose A = 10 cells µL −1 day −1 , µ = 0.0139 day −1 and T(0) = 600 cells µL −1 . For simplicity, we take N(α) = 1. Figure 1 shows that when α = β = 1 the graph of (20) coincides with that of the ordinary differential equation given by (17). In addition, when the order of fractional derivative increases the solution given by (20) converges rapidly to the steady state A µ .

Conclusions
In this work, we have proposed a new fractional derivative with non-singular kernel which includes the Caputo-Fabrizio fractional derivative, the Atangana-Baleanu fractional derivative and the recent weighted Atangana-Baleanu fractional derivative presented [20]. We have derived some fundamental properties of this new generalized derivative and applied it to a model in epidemiology as well as in virology. In addition, we have studied numerically the impact of the order on the dynamical behavior of the biological model.
Modeling other biological systems with memory or having hereditary properties using the new fractional derivative, and also the determination of other important properties of this new derivative, will be the subject of our future works.
Funding: This research received no external funding.