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Article

Metabolic Syndrome and Its Associations with Components of Sarcopenia in Overweight and Obese Older Adults

1
Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC 3168, Australia
2
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3168, Australia
3
Australian Institute for Musculoskeletal Science (AIMSS), Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St Albans, VIC 3021, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(2), 145; https://doi.org/10.3390/jcm8020145
Received: 23 December 2018 / Revised: 20 January 2019 / Accepted: 24 January 2019 / Published: 27 January 2019
(This article belongs to the Special Issue Sarcopenia in Older Adults)
Ageing, obesity and the metabolic syndrome (MetS) may all contribute to poor muscle health (sarcopenia). This study aimed to determine the cross-sectional associations between MetS (International Diabetes Federation classification) and sarcopenia (revised European Working Group on Sarcopenia in Older People definition) in 84 overweight and obese older adults. Components of sarcopenia included muscle strength (hand grip and leg extension), physical performance (stair climb test and short physical performance battery (SPPB), including gait speed and repeated chair stands time), muscle mass (appendicular lean mass (ALM), dual-energy X-ray absorptiometry), muscle size (peripheral quantitative computed tomography-determined calf and forearm cross-sectional area (CSA)) and muscle quality (muscle density and strength normalised to lean mass). Waist circumference was associated with greater muscle size, but poorer leg extension strength, chair stands and stair climb time, gait speed, SPPB scores and muscle quality measures (all p < 0.05). MetS was positively associated with ALM and forearm muscle CSA, and negatively associated with muscle quality measures and chair stands time (all p < 0.05). MetS is associated with larger muscle size, yet poorer muscle quality in overweight and obese older adults. Assessments of muscle function and quality should be considered for obese older adults and those with MetS. View Full-Text
Keywords: metabolic syndrome; sarcopenia; obesity; older adults metabolic syndrome; sarcopenia; obesity; older adults
MDPI and ACS Style

Mesinovic, J.; McMillan, L.B.; Shore-Lorenti, C.; De Courten, B.; Ebeling, P.R.; Scott, D. Metabolic Syndrome and Its Associations with Components of Sarcopenia in Overweight and Obese Older Adults. J. Clin. Med. 2019, 8, 145. https://doi.org/10.3390/jcm8020145

AMA Style

Mesinovic J, McMillan LB, Shore-Lorenti C, De Courten B, Ebeling PR, Scott D. Metabolic Syndrome and Its Associations with Components of Sarcopenia in Overweight and Obese Older Adults. Journal of Clinical Medicine. 2019; 8(2):145. https://doi.org/10.3390/jcm8020145

Chicago/Turabian Style

Mesinovic, Jakub, Lachlan B. McMillan, Catherine Shore-Lorenti, Barbora De Courten, Peter R. Ebeling, and David Scott. 2019. "Metabolic Syndrome and Its Associations with Components of Sarcopenia in Overweight and Obese Older Adults" Journal of Clinical Medicine 8, no. 2: 145. https://doi.org/10.3390/jcm8020145

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