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Importance of Beta Cell Function for the Treatment of Type 2 Diabetes

Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
J. Clin. Med. 2014, 3(3), 923-943;
Received: 30 April 2014 / Revised: 2 June 2014 / Accepted: 24 June 2014 / Published: 14 August 2014
(This article belongs to the Special Issue Obesity, Diabetes and Metabolic Syndrome)
Type 2 diabetes (T2DM) is characterized by insulin resistance and beta cell dysfunction. Recent evidence has emerged that beta cell dysfunction is a common pathogenetic feature of both type 1 and type 2 diabetes, and T2DM never develops without beta cell dysfunction. Therefore, treatment of T2DM should aim to restore beta cell function. Although the treatment of T2DM has greatly improved over the past few decades, remaining issues in the current treatment of T2DM include (1) hypoglycemia; (2) body weight gain; (3) peripheral hyperinsulinemia and (4) postprandial hyperglycemia, which are all associated with inappropriate insulin supplementation, again underpinning the important role of endogenous and physiological insulin secretion in the management of T2DM. This review summarizes the current knowledge on beta cell function in T2DM and discusses the treatment strategy for T2DM in relation to beta cell dysfunction. View Full-Text
Keywords: type 2 diabetes; beta cell; insulin secretion; therapy type 2 diabetes; beta cell; insulin secretion; therapy
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MDPI and ACS Style

Saisho, Y. Importance of Beta Cell Function for the Treatment of Type 2 Diabetes. J. Clin. Med. 2014, 3, 923-943.

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