Buried Autologous Breast Reconstruction: Outcomes and Technical Considerations

The purpose of this study is to compare outcomes in patients undergoing buried and non-buried free flaps for breast reconstruction, in addition to evaluating the safety and reliability of venous flow couplers. A retrospective review was performed of all patients undergoing free flap breast reconstruction between 2013 and 2023. The primary outcomes were free flap failure, complications and the number of procedures required to complete the reconstructive journey. A total of 322 flaps were performed in 254 consecutive patients, with 47.5% (n = 153) being buried and 52.0% (n = 169) being non-buried reconstructions. The most common flap of choice being deep inferior epigastric artery perforator flaps (81.9%) followed by profunda artery perforator flaps (14.3%). There was no significant difference between the two groups in complications, including flap failure (buried 2.0% vs. non-buried 1.8% p = 0.902). There was a significant reduction in the number of procedures required to complete the reconstructive journey, with 52.2% (n = 59) of patients undergoing single-stage breast reconstruction in the buried group compared with only 25.5% (n = 36) in the non-buried group (p < 0.001). Two (0.6%) patients experienced a false negative in which the signal of the flow coupler was lost but the flap was perfused during re-exploration. No flap losses occurred without being identified in advance by a loss of audible venous flow signal. Buried free flap breast reconstruction is safe and requires fewer operations to complete patients’ reconstructive journey. Flow couplers are a safe and effective method of monitoring buried free flaps in breast reconstruction.


Introduction
Autologous breast reconstruction is the gold standard following mastectomy for breast cancer [1].In a delayed setting, a skin paddle is required to address the deficiency of skin.By contrast, in an immediate setting, skin sparing mastectomy classically involves a skin paddle at the site of the excised nipple areolar complex (NAC).With an increasing move towards nipple sparing mastectomies (NSM), the requirement for a skin paddle is often solely for the clinical monitoring of flap perfusion [2][3][4].Adopting alternative methods of flap monitoring enables buried flap reconstruction, with de-epithelisation of the entire flap and preservation of the native breast envelope [5].
Combining NAC preservation with buried flaps can significantly reduce the stigmata of surgery on the reconstructed breast.This has been shown to improve sexual and psychological wellbeing, reducing the number of symmetrising and adjustment procedures required and thus streamlining the patient journey and avoiding "reconstructive burnout" [6][7][8][9].However, this is yet to become standard practice in most specialist centres.
While an early series of buried flaps raised concerns about the reliability of monitoring and a high revision rate [10], more recently published data has demonstrated their safety [11].Our recently published series demonstrated buried flaps to be safe and reliable, with a comparable flap failure rate and fewer revisions over time than a matched cohort of flaps with a skin paddle [6].A total of 50% patients with buried flaps had single-stage reconstruction compared to 29% in the skin paddle group.This was due to the preservation of the native NAC negating the requirement for nipple reconstruction, in combination with fewer secondary adjustments of the breast mound with lipofilling or liposuction or the need to excise the monitoring skin paddle.
Despite evidence of the safety of buried flaps, one limiting factor to consider is a lack of familiarity with venous flow couplers used to monitor the flaps.Most of the literature surrounding their use is within the field of head and neck reconstruction [12].Whilst some small studies exist, there remains a lack of evidence regarding their positive predictive value of identifying a compromised flaps in breast reconstruction [13].Others have questioned the potential morbidity associated with their removal, with a perceived higher rate of haematoma and flap loss [14].
This study aims to compare the outcomes of patients undergoing autologous breast reconstruction using buried and non-buried flaps.The primary outcomes were flap loss, the number of procedures required to complete the reconstructive journey and complications.In addition, we will also explore the reliability and accuracy of flow couplers in breast flap monitoring and present a learning curve associated with their use.To the author's knowledge, this will constitute the largest published series of buried flaps for breast reconstruction.

Subjects
All patients undergoing autologous breast reconstruction by the senior author (VR) between 2013 and August 2023 were included for review.This included patients undergoing reconstruction at three units in the public and private sectors in London, UK.Demographics, indications, pre-operative, intra-operative and post-operative details; complications; and further surgeries to improve breast appearance were collected.All data were collected from a prospectively maintained database or from the patients' electronic record.Flap failure was defined as an entire flap that was unsalvageable following re-exploration.Partial flap failure was a flap that underwent subsequent sub-total debridement secondary to poor perfusion.Fat necrosis was defined clinically as palpable induration with or without further intervention.

Pre-Operative
Pre-operatively, all patients were offered implant-based and autologous-based breast reconstruction.The requirement for adjuvant radiotherapy was not a contraindication for immediate autologous reconstruction.Patients were shown representative photographs of flap reconstructions from deep inferior epigastric perforator (DIEP), profunda artery perforator (PAP) and superior gluteal artery perforator (SGAP) flaps, and if all were feasible, they were offered a choice of reconstruction.All patients who were deemed oncologically safe by the multidisciplinary team were offered NSM. Patients were offered simultaneous symmetrisation using mastopexy, reduction mastopexy or fat grafting where it was deemed that this was likely to be necessary at any point in the future.

Intra-Operative Skin Envelope
For patients satisfied with their pre-operative shape, an infra mammary fold (IMF) incision for the mastectomy and a buried flap were preferred, as this gives the least surgical stigmata in patients undergoing NSM (Figure 1).In patients requiring management of the skin envelope due to ptosis or a reduction in volume, the preferred mastectomy approach was a Wise pattern, with a buried flap, where the nipple was preserved on an inferior dermal pedicle or replaced as a free nipple graft (Figure 2).For patients in which the nipple could not be preserved for oncological reasons, but the skin envelope was adequate, a periareolar approach was taken and directly closed post-operatively.In those in which the nipple was sacrificed but the skin envelope required management, the Wise pattern was closed entirely to bury the flap (Figure 3).In cases of delayed reconstruction or where a significant volume increase occurred, the additional skin was provided by the flap and the flap was not buried (Figure 4).The algorithm for the approach to mastectomy and flap inset is summarised in Figure 5.
J. Clin.Med.2024, 13, x FOR PEER REVIEW 3 of 13 adequate, a periareolar approach was taken and directly closed post-operatively.In those in which the nipple was sacrificed but the skin envelope required management, the Wise pattern was closed entirely to bury the flap (Figure 3).In cases of delayed reconstruction or where a significant volume increase occurred, the additional skin was provided by the flap and the flap was not buried (Figure 4).The algorithm for the approach to mastectomy and flap inset is summarised in Figure 5.     adequate, a periareolar approach was taken and directly closed post-operatively.In those in which the nipple was sacrificed but the skin envelope required management, the Wise pattern was closed entirely to bury the flap (Figure 3).In cases of delayed reconstruction or where a significant volume increase occurred, the additional skin was provided by the flap and the flap was not buried (Figure 4).The algorithm for the approach to mastectomy and flap inset is summarised in Figure 5.      adequate, a periareolar approach was taken and directly closed post-operatively.In those in which the nipple was sacrificed but the skin envelope required management, the Wise pattern was closed entirely to bury the flap (Figure 3).In cases of delayed reconstruction or where a significant volume increase occurred, the additional skin was provided by the flap and the flap was not buried (Figure 4).The algorithm for the approach to mastectomy and flap inset is summarised in Figure 5.      Symmetrisation was usually undertaken as a Wise pattern mastopexy or reduction.Where the flap was larger than the initial breast, immediate fat grafting to the contralateral breast was performed.
DIEP, PAP and SGAP flaps were raised in a standard fashion and anastomosed to the internal mammary artery (IMA) and internal mammary vein (IMV) at the level of the 3rd or 4th intercostal.Where flaps were stacked, they were anastomosed most commonly with an antegrade/retrograde approach onto the IMA/IMV or onto a large side branch for an intra-flap anastomosis.When performed, the intra-flap anastomosis was most commonly performed using a flow coupler for arterial and venous anastomosis.Symmetrisation was usually undertaken as a Wise pattern mastopexy or reduction.Where the flap was larger than the initial breast, immediate fat grafting to the contralateral breast was performed.DIEP, PAP and SGAP flaps were raised in a standard fashion and anastomosed to the internal mammary artery (IMA) and internal mammary vein (IMV) at the level of the 3rd or 4th intercostal.Where flaps were stacked, they were anastomosed most commonly with an antegrade/retrograde approach onto the IMA/IMV or onto a large side branch for an intra-flap anastomosis.When performed, the intra-flap anastomosis was most commonly performed using a flow coupler for arterial and venous anastomosis.
Flow couplers (Synovis™, Birmingham, AL, USA) were used to monitor flow at all venous anastomotic sites.When placing the coupler, the wire is removed from the dock before a standard venous coupler anastomosis is performed.A 16G cannula is then passed  Symmetrisation was usually undertaken as a Wise pattern mastopexy or reduction Where the flap was larger than the initial breast, immediate fat grafting to the contralatera breast was performed.DIEP, PAP and SGAP flaps were raised in a standard fashion and anastomosed t the internal mammary artery (IMA) and internal mammary vein (IMV) at the level of th 3rd or 4th intercostal.Where flaps were stacked, they were anastomosed most commonl with an antegrade/retrograde approach onto the IMA/IMV or onto a large side branch fo an intra-flap anastomosis.When performed, the intra-flap anastomosis was most com monly performed using a flow coupler for arterial and venous anastomosis.
Flow couplers (Synovis™, Birmingham, AL, USA) were used to monitor flow at a venous anastomotic sites.When placing the coupler, the wire is removed from the doc before a standard venous coupler anastomosis is performed.A 16G cannula is then passe "in to out" such that the wire can be passed "out to in" prior to reinserting the wire int the dock (Figure 6).The external wire is secured to the skin with Dermabond™ Prineo™ (Ethicon, Somerville, NJ, USA) to reduce the risk of accidental displacement.Care shoul be taken to disconnect wires when removing drapes, fitting the bra and transferring th Flow couplers (Synovis™, Birmingham, AL, USA) were used to monitor flow at all venous anastomotic sites.When placing the coupler, the wire is removed from the dock before a standard venous coupler anastomosis is performed.A 16G cannula is then passed "in to out" such that the wire can be passed "out to in" prior to reinserting the wire into the dock (Figure 6).The external wire is secured to the skin with Dermabond™ Prineo™ (Ethicon, Somerville, NJ, USA) to reduce the risk of accidental displacement.Care should be taken to disconnect wires when removing drapes, fitting the bra and transferring the patient from the operating table.All wounds were closed with STRATAFIX TM (Ethicon, Somerville, NJ, USA) and Dermabond™ Prineo™ skin closure system (Figure 7).patient from the operating table.All wounds were closed with STRATAFIX TM (Ethicon Somerville, NJ, USA) and Dermabond™ Prineo™ skin closure system (Figure 7).

Post-Operative
Post-operatively, patients with buried flaps were monitored using flow couplers, and they were monitored for excessive swelling, firmness and high drain output.For patient with visible skin paddles, standard monitoring for capillary refill, colour, temperature and Doppler was undertaken.Flow coupler wires were removed with gentle traction prior t discharge on post-operative day 2 or 3. Patients underwent a standard enhanced recovery program, with the avoidance of excess intra-operative fluids and minimal post-operativ opiate analgesia [15].

Statistical Tests
Descriptive statistics were used to compare demographics, operative times, compli cations and the number of revisions between patients undergoing buried and non-buried flaps.A t-test was used for continuous variables, and a z-test of proportions was used t compare incidences between groups.A value of p < 0.05 was considered statistically sig nificant.Where missing data were present, variables were averaged with the availabl data points.
Results are reported as per the Strengthening the Reporting of Observational studie in Epidemiology (STROBE) guidelines for case-control studies [16].patient from the operating table.All wounds were closed with STRATAFIX TM ( Somerville, NJ, USA) and Dermabond™ Prineo™ skin closure system (Figure 7).

Post-Operative
Post-operatively, patients with buried flaps were monitored using flow coup they were monitored for excessive swelling, firmness and high drain output.For with visible skin paddles, standard monitoring for capillary refill, colour, tempera Doppler was undertaken.Flow coupler wires were removed with gentle traction discharge on post-operative day 2 or 3. Patients underwent a standard enhanced r program, with the avoidance of excess intra-operative fluids and minimal post-o opiate analgesia [15].

Statistical Tests
Descriptive statistics were used to compare demographics, operative times, cations and the number of revisions between patients undergoing buried and non flaps.A t-test was used for continuous variables, and a z-test of proportions was compare incidences between groups.A value of p < 0.05 was considered statistic nificant.Where missing data were present, variables were averaged with the a data points.
Results are reported as per the Strengthening the Reporting of Observationa in Epidemiology (STROBE) guidelines for case-control studies [16].

Post-Operative
Post-operatively, patients with buried flaps were monitored using flow couplers, and they were monitored for excessive swelling, firmness and high drain output.For patients with visible skin paddles, standard monitoring for capillary refill, colour, temperature and Doppler was undertaken.Flow coupler wires were removed with gentle traction prior to discharge on post-operative day 2 or 3. Patients underwent a standard enhanced recovery program, with the avoidance of excess intra-operative fluids and minimal post-operative opiate analgesia [15].

Statistical Tests
Descriptive statistics were used to compare demographics, operative times, complications and the number of revisions between patients undergoing buried and non-buried flaps.A t-test was used for continuous variables, and a z-test of proportions was used to compare incidences between groups.A value of p < 0.05 was considered statistically significant.Where missing data were present, variables were averaged with the available data points.
Results are reported as per the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines for case-control studies [16].

Demographics and Flap Details
A total of 322 flaps were performed in 254 consecutive patients by the senior author (VR) between 2013 and 2023 for autologous breast reconstruction.The proportion of buried flaps was 47.5%, whilst 52.0% were not buried with a cutaneous paddle.The demographics, flap types and indications are presented in Table 1.The mean follow-up was 30.2 months (Standard Deviation (SD) ± 27.8).There were no significant differences in patient demographics or flap type selection between the groups.The most common flap choice being the DIEP flap (81.9%) followed by PAP flaps (14.3%).There were significantly more immediate reconstructions in the buried flap group and similarly a greater proportion of nipple sparing and skin-reducing procedures within this cohort.Of the patients undergoing buried flaps, 24.7% (n = 28) underwent immediate symmetrisation with a contralateral reduction or mastopexy.This compared to 18.4% (n = 26) in the non-buried group.Over time, there was a trend towards an increasing proportion of buried free flaps, with 74.3% of breast reconstructions being buried in 2023 (Figure 8).BMI-body mass index, DIEP-deep inferior epigastric perforator, PAP-profunda artery perforator, SGAP-superior gluteal artery perforator, SIEA-superficial inferior epigastric artery, ALTanterolateral thigh.
Over time, there was a trend towards an increasing proportion of buried free flaps, with 74.3% of breast reconstructions being buried in 2023 (Figure 8).

Complications
There was a significantly longer follow-up period in the non-buried flap group (41.4 months (SD ± 29.2)) compared to patients undergoing buried free flap reconstruction (12.8 months (SD ± 11.4).
There were six flap losses (1.7%) and one partial flap loss (0.3%), of which two occurred in two individual patients undergoing a buried four-flap procedure.In the buried flap group, there were three (2.0%) returns to theatre in which a clinical concern with the flap was not found (a negative takeback).Two of these were due to the loss of coupler signal, and one was due to swelling.There was one negative takeback in the non-buried

Complications
There was a significantly longer follow-up period in the non-buried flap group (41.4 months (SD ± 29.2)) compared to patients undergoing buried free flap reconstruction (12.8 months (SD ± 11.4).
There were six flap losses (1.7%) and one partial flap loss (0.3%), of which two occurred in two individual patients undergoing a buried four-flap procedure.In the buried flap group, there were three (2.0%) returns to theatre in which a clinical concern with the flap was not found (a negative takeback).Two of these were due to the loss of coupler signal, and one was due to swelling.There was one negative takeback in the non-buried group due to swelling.There were no significant differences in the incidence of any complications between the groups, as seen in Table 3. RTT-return to theatre, SIEV-superficial inferior epigastric vein, NAC-nipple areolar complex.

Additional Procedures
There was a significant difference between the two groups in the proportion of women who required additional procedures to improve the appearance of their breasts.The majority (52.2%, n = 59) of women in the buried group did not require further surgery to improve their breast appearance compared to 25.5% (n = 36) of those in the non-buried group (p < 0.001).The most significant difference was in the need for nipple reconstruction, which was only 18.6% (n = 21) in the buried group compared to 51.1% (n = 72) in the non-buried group due to the greater proportion of women who underwent NSM (p ≤ 0.001).Additional data regarding further reconstructive operations to improve breast cosmesis are presented in Table 4.

Discussion
This study demonstrates no difference in the rates of flap failure (buried 2.0% vs. non-buried 1.8% p = 0.902) or post-operative complications between buried or non-buried free flaps for breast reconstruction.A greater proportion of patients undergoing buried free flap reconstruction completed their breast reconstruction journey in a single stage and had a lower average number of reconstructive procedures (52.2% no further reconstructions in the buried group vs. 25.5% non-buried, p < 0.001).Venous flow couplers were utilised to monitor a total of 322 flap, including 153 buried flaps, with no flap losses occurring without being identified in advance via a loss of audible venous flow signal.There was a 2.0% negative takeback rate relating to loss of venous coupler signal but a perfused flap on return to theatre.There was no reported morbidity with coupler wire removal at the bedside.
There were no significant differences in baseline demographic data between the buried and non-buried groups, other than a greater proportion of NSM (buried 57.5% vs. non-buried 7.7%, p ≤ 0.001) and immediate reconstructions in the buried group (buried 82.4% vs. non-buried 60.9% p ≤ 0.001).Patients who had a mastectomy and subsequent delayed autologous reconstruction will have a deficiency of skin, and therefore have greater representation in the non-buried group due to their skin paddle.This study showed an increased intra-operative time for buried flaps (buried 416.4 min (SD ± 117.9) vs. nonburied 383.7 min (SD ± 287.8) p = 0.031).This is likely to reflect the higher proportion of patients undergoing immediate reconstruction in the buried group, as well as the higher proportion of unilateral patients that underwent concurrent symmetrisation (buried 31.9% vs. non-buried 21.3% p = 0.085).We recognise the importance of experienced co-surgeons to facilitate simultaneous operating, reducing the operative time and thus optimising patient safety [17].A recent meta-analysis by Escandón et al. demonstrated the value of co-surgeon operators on operative time for autologous breast reconstruction, although they found surgical complications comparative compared to a single-surgeon approach [18].
The average ischaemia time in the buried flap group was 62.7 min (SD ± 24.7) compared to 69.0 min (SD ± 25.0) in the non-buried group (p = 0.036).However, the clinical significance of this statistical difference is unlikely to be of relevance.There was a significantly longer follow-up period in the non-buried flap group (41.4 months (SD ± 29.2)) compared to patients undergoing buried free flap reconstruction (12.8 months (SD ± 11.4).This is likely to reflect the increasing proportion of buried flaps over the course of the series.
The flap failure rate in both the buried and non-buried cohort was comparable to the most recent published report from the UK National Flap Registry, reporting a return to theatre rate of 7% for free flap reconstructions with a flap failure rate of 2.5% nationwide [19,20].The results of this study are also in line with a large multi-centre international published series citing a 2% rate of total flap loss in 4577 DIEP flaps [21].This demonstrates that buried free flaps can be reliably performed and monitored.The perceived increased haematoma and flap failure rate described in smaller unmatched series was not observed in our study [14].As previously described, we have refined our technique for placing and securing the coupler wire, reducing dislodgement and facilitating safe removal.
Buried free flaps, combined with nipple-sparing approaches and concurrent symmetrisation, significantly reduce the requirement for additional procedures following free flap breast surgery.The UK national average for secondary adjustments following free flap breast surgery is 1.3, which is significantly higher than the average for the buried flap group of 0.62 in this study [19].Another series from high-volume microsurgical units describes an average rate of 3.3 subsequent surgical episodes after their primary reconstructions [22].In a series by Frey at al., the assumption that buried flaps lead to fewer revisional surgeries was challenged.A total of 221 free flaps were included in their series, although only 50 of those were buried.They described a greater average of revisional procedures in the buried group than that with a skin paddle (buried 0.82 vs. non-buried 0.44).Revisional procedures included lipofilling and contralateral symmetrising surgery, with some patients in the non-buried cohort choosing not to have their skin paddle excised [5].
The most common secondary procedures in our series across both groups was lipofilling, which was performed significantly more in the non-buried setting (buried 30.1% vs. non-buried 48.2% p = 0.003).Nipple reconstruction with local flaps was only performed in 18.6% (n = 21) in the buried group compared to 51.1% (n = 72) in the non-buried group due to the greater proportion of women who underwent NSM (p ≤ 0.001).
Halani et al. introduced the concept of reconstructive burnout following mastectomy to describe women who did not complete their reconstruction due to the emotional and physical toll of repeated operative procedures [7].Reducing the number of additional surgeries through the adoption of single-stage breast reconstruction and the use of buried flaps can reduce the emotional toll of a protracted reconstructive journey.Additionally, some providers are restricting funding for secondary procedures following reconstruction.These economic considerations are additional motivators for minimising the need for secondary surgery following autologous breast reconstruction [19].Due to the prioritisation of treating primary cancers, there is often a protracted wait for revisional surgery, which is further extenuated by the ongoing COVID-19 backlog of elective surgical care [23].
In our series, all buried flaps were monitored with venous flow couplers only, without monitoring arterial patency with implantable Dopplers.Venous insufficiency is the most common aetiology for flap re-exploration and subsequent free flap failure, and venous flow couplers can identify a lack of flow almost immediately [21,24].The loss of arterial flow is less sensitive, as there is a well-recognised issue with falsely transmitted Cook-Schwartz signal in the absence of flow [25,26].Some studies questioned the reliability of flow couplers, with early small studies suggesting increased rates of thrombosis and higher rates of negative explorations [27].However, this has not been our experience, along with other larger published studies, which have shown an equivocal rate of microsurgical complications as compared to standard couplers [6,13].It is of note that a 2.0% rate of negative re-exploration was noted in this study, leading to unnecessary morbidity with return to theatre in two patients.Significantly, there were no flaps losses that were not identified in advance by a loss in the venous coupler signal.
There are several technical considerations when introducing buried flaps into a service.Firstly, a close working relationship with breast surgeons is required in order to ensure that, where appropriate, patients are considered for NSM and that the mastectomy is performed in a way to optimise the breast skin envelope.Our preferred approach was either an IMF incision, Wise pattern or Wise pattern with dermal nipple pedicle, depending on the degree of ptosis (Figure 2).In their series of 163 patients, Salibian et al. observed IMF and inverted-T incisions to have a significantly higher risk of mastectomy flap necrosis [28].Whilst stratification of mastectomy flap complications was not performed as part of our analysis, there was no significant difference between mastectomy flap or nipple necrosis across the buried and non-buried groups.The IMF approach can sometimes restrict access to the 3rd costal cartilage, requiring the 4th costal cartilage to be prepared, which may result in smaller calibre recipient vessels.
Secondly, the introduction of buried flaps and the associated venous flow coupler monitoring has an increased upfront cost.Initially, it requires an investment in monitoring equipment and training of staff.Additionally, flow couplers have a higher unit cost compared to standard venous couplers, calculated as GBP 680 vs. GBP 170, respectively, by Chadwick et al. [13].However, these incrementally increased costs need to be offset by the reduced need for secondary surgery demonstrated with buried flaps [6,29].
Familiarity with monitoring using flow couplers has additional benefits, even for patients with cutaneous skin paddles.The authors have routinely used flow couplers in addition to skin paddles and cutaneous Doppler monitoring due to the earlier detection of flap compromise.Nursing staff have reported preferring the binary outcome of whether flow is present or not compared to the subjective assessment of skin paddles [11].A subjective assessment of skin paddles can be challenging in non-Caucasian skin and, as such, is associated with a higher incidence of flap loss due to delayed flap salvage [30].

Limitations
The limitations of this study include that this series is composed of a single surgeon's experience and, therefore, may limit its reproducibility.Due to the inclusion of patients in (a) Pre-operative (b) Post-operative at 8 months

Figure 2 .
Figure 2. Bilateral NSM with Wise pattern skin excision; nipple preserved on inferior dermal pedicle; immediate buried DIEP.

Figure 3 .
Figure 3. Bilateral skin reducing mastectomy with Wise pattern excision; immediate buried DIEP flap.

Figure 2 .
Figure 2. Bilateral NSM with Wise pattern skin excision; nipple preserved on inferior dermal pedicle; immediate buried DIEP.

Figure 3 .
Figure 3. Bilateral skin reducing mastectomy with Wise pattern excision; immediate buried DIEP flap.

Figure 2 .
Figure 2. Bilateral NSM with Wise pattern skin excision; nipple preserved on inferior dermal pedicle; immediate buried DIEP.

Figure 2 .
Figure 2. Bilateral NSM with Wise pattern skin excision; nipple preserved on inferior dermal pedicle; immediate buried DIEP.

Figure 3 .
Figure 3. Bilateral skin reducing mastectomy with Wise pattern excision; immediate buried DIEP flap.

Figure 3 .
Figure 3. Bilateral skin reducing mastectomy with Wise pattern excision; immediate buried DIEP flap.

Figure 4 .
Figure 4. Delayed reconstruction of right breast, removal of implant and exchange for stacked PAPs with skin paddle due to inadequate skin envelope; subsequent lipofilling and nipple reconstruction with local flap.

Figure 5 .
Figure 5.Our algorithm for the approach to mastectomy and flap inset.

Figure 4 .
Figure 4. Delayed reconstruction of right breast, removal of implant and exchange for stacked PAPs with skin paddle due to inadequate skin envelope; subsequent lipofilling and nipple reconstruction with local flap.

Figure 4 .
Figure 4. Delayed reconstruction of right breast, removal of implant and exchange for stacked PAP with skin paddle due to inadequate skin envelope; subsequent lipofilling and nipple reconstructio with local flap.

Figure 5 .
Figure 5.Our algorithm for the approach to mastectomy and flap inset.

Figure 5 .
Figure 5.Our algorithm for the approach to mastectomy and flap inset.

Figure 6 .
Figure 6.Reinsertion of flow coupler wire into the dock post-anastomosis.

Figure 6 .
Figure 6.Reinsertion of flow coupler wire into the dock post-anastomosis.

Figure 6 .
Figure 6.Reinsertion of flow coupler wire into the dock post-anastomosis.

Figure 8 .
Figure 8. Proportion of buried vs. non-buried flaps over time.

Figure 8 .
Figure 8. Proportion of buried vs. non-buried flaps over time.

Table 1 .
Patient demographics and operative description.

Table 3 .
Incidence of complications in buried and non-buried flaps.

Table 4 .
Additional procedures to improve breast or donor site cosmesis.