Rehabilitation for Musculoskeletal Disorders: The Emergence of Serious Games and the Promise of Personalized Versions Using Artificial Intelligence

According to the World Health Organization (WHO), musculoskeletal conditions are among the most common health problems, affecting approximately 1 [...].

covering virtual reality (VR), augmented reality (AR), and mixed reality (MR). All these types of extended realities have been used in musculoskeletal rehabilitation, particularly to provide more advanced instructions and feedback to the patients and place them in immersive and interactive environments. XR plays an important role in the communication with the patients, particularly for complex exercises and movements that should be executed precisely. A variety of devices can be used to deliver XR. Nevertheless, a display in the form of a screen, tablet, or headset is often considered because of its intuitive nature [9]. In this case, avatars or graphics are frequently used to guide patient movements. For example, to train head mobility in patients with chronic neck pain, Sarig Bahat et al. [12] used a headset to place the patients in a VR sky where they controlled an airplane by moving their head. Comprehensive and intuitive visual feedback has been shown to be beneficial for motor learning and promote engagement [9]. Similarly, sounds can be used, on their own or coupled with a display, to deliver auditory cues, instructions, or feedback [13,14]. Multi-sensory experiences, notably including haptics, are also possible [15,16]. Moreover, performance metrics, which provide quantitative data on parameters such as speed, accuracy, and the number of repetitions, are often included to help the patients track their progress.
Gamification is the third fundamental technological component of serious games. It consists of adding game aspects into the rehabilitation process, therefore improving motivation and involvement, which are critical for treatment success [2,17,18]. Gamification can be seen as a rehabilitation strategy where exercises and activities are transformed into interactive games designed to improve participation and enjoyment while keeping the focus on the therapeutic goals. To create a more immersive and goal-oriented experience, serious games incorporate aspects such as challenges, prizes, progress tracking, and competition. For example, in the case of total knee arthroplasty rehabilitation, Qiu et al. [19] proposed a fishing serious game where, in addition to controlling the catching of the fishes with the knee flexion angle, elements demanding decision making, such as selecting the baits and solving puzzles, as well as rewards based on the caught fish attributes, have been included.
Serious games have been booming lately, with highly promising results for a variety of musculoskeletal conditions. For instance, they have been shown to be effective in joint arthroplasty rehabilitation [20][21][22][23], as well as in the treatment of chronic neck pain and shoulder impingement syndrome [24]. Furthermore, pain reductions have been reported in patients with acute burns [25,26], and in patients with chronic musculoskeletal disorders [27,28]. Encouraging results were also obtained regarding sport injury prevention [29]. In addition, reduced anxiety and stress, as well as increased enjoyment during physical rehabilitation and physiotherapy were observed with serious games [26]. Of course, the efficacy generally reported for serious games so far should be considered critically. Serious games is an emerging field and further assessment of more completed solutions on larger populations will be needed to be more specific on the advantages and drawbacks. For example, multiple studies reported no significant differences in clinical outcomes between serious games and traditional exercises, but nonetheless considered the instrumentation to be beneficial [21,24,25,28]. In these cases, the conclusions were mostly driven by the increase in the sense of engagement [3] and the possibility to deliver high-quality care at lower costs, contributing to more accessible and efficient healthcare [4]. While this editorial focuses on musculoskeletal rehabilitation, it is important to mention that serious games for other medical conditions have been proposed with comparable positive results and appreciations, notably for stroke [30], Parkinson's disease [31], and spinal cord injury [32].
Following the engaging state-ot-the-art advancements presented above, a limitation, or rather a perspective, should be highlighted. While current serious games for musculoskeletal conditions can be adapted by clinicians to the individual needs of the patients, there is a lack of support in doing so. In fact, currently, the adaptations are mostly based on the clinicians' expertise. Similarly to the trend observed in other medical applications [33][34][35], adding a data science component to serious games could fully unlock their potential by allowing personalized treatment plans based on the therapeutic trajectories observed with prior patients. To address this challenge, it will be necessary to build large datasets with patient characteristics and progression, and to develop mathematical models that are able to suggest personalized rehabilitation programs. This look into the future might not be that distant, as serious games can already store relevant data about the patients and their rehabilitation journey, and artificial intelligence (AI) algorithms are capable of processing large amounts of data to identify patterns and hopefully soon recommend adaptations to the serious games based on the individual situation of each patient.
In conclusion, serious games are extremely promising for the rehabilitation of musculoskeletal conditions and their value should significantly increase in the future with the incorporation of AI to suggest personalized therapeutic objectives and individualize the games. In view of the importance of musculoskeletal rehabilitation worldwide, serious games could play a major role in improving global health and lower the societal and economic burden of musculoskeletal disorders. Finally, it is worth mentioning that serious games can be deployed at home [4] and that newer technologies for movement measurement and XR [36,37] will facilitate such implementation in the future. As time progresses, we will be more exposed to these newer technologies in our daily life, which should also contribute to better acceptance and clinical outcomes of rehabilitation using serious games.

Conflicts of Interest:
The authors declare no conflict of interest.