Isolation of Pseudomonas aeruginosa in Stable Chronic Obstructive Pulmonary Disease Patients—Should We Treat It?

Chronic obstructive pulmonary disease (COPD) is one of the most frequent inflammatory diseases of the airways [...].

,000 patients (derived from cohort studies in the majority of cases) who were followed for 1 to 7 years concluded that the adjusted risk of death was almost double in those patients with COPD and isolation (single or repeated) of PA, compared to those in whom it had never been isolated (HR 1.95; 95% CI: 1.34 to 2.84) [18]. In this respect, another study further concluded that the risk of death was more than tripled (HR 3.06; 95%CI: 1.8 to 5.2) if PA could be isolated multiple times (CBI situation) [19]. In fact, PA is the only PPM that has been shown to be associated with an increase in mortality in COPD independently of other confounding variables [18]. As regards any increase in the number and severity of exacerbations, the results are more mixed, although most studies agree that PA is associated with such an increase [18]. Finally, there is hardly any literature available on PA's effect on lung function or its evolution, or on patients' quality of life [18]. Significantly, it is still not known whether PA is a marker of COPD severity (i.e., whether its isolation occurs as a consequence of the advanced stage of the disease) or whether PA itself causes the accelerated deterioration of COPD. It is very probable that both circumstances coexist, since PA is a pathogen that usually takes advantage of extensive disruption and damage to defence mechanisms in order to infect the airways, although more rapid deterioration of COPD has also been observed after a first isolation of PA (since this first isolation is usually performed with sputum samples; however, there is no guarantee that the PA has not already been infecting the airways of a COPD patient for some time) [20].
However, the main question that clinicians face is: what should I do when faced with PA isolation in a COPD patient? Although the current scientific evidence does not permit any definitive answer to this question, some steps do seem recommendable: first, the performance of high-resolution computed tomography (HRCT) to rule out the presence of bronchiectasis (which is considered a treatable trait in COPD); second, a clinical assessment of the patient (especially the characteristics of the sputum and the number and severity of exacerbations); and, finally, microbiological monitoring of the patient's sputum (to assess the persistence of PA over time), as already recommended by some international COPD guidelines [5,21]. These steps open up various therapeutic scenarios, in the opinion of the authors of this editorial. 1. A patient with symptomatic COPD and bronchiectasis (BCOS). In this case, there is considerable unanimity that it is necessary to follow the recommendations of the bronchiectasis guidelines regarding the necessary antibiotic and/or anti-inflammatory treatment after the first PA isolation [15][16][17]. 2. A patient with COPD and isolated PA (single or multiple) but without bronchiectasis. In this case, the recommendation would be the treatment of PA infection in the case of patients with multiple exacerbations or clinical deterioration secondary to this infection, with earlier and more forceful treatment more recommendable in the case of CBI [7,8]. 3. A patient with asymptomatic COPD and single or multiple isolations of PA. In this case, it is possible that close clinical and microbiological monitoring of the patient is the most suitable approach, with treatment applied in the event of clinical deterioration or an increase in the number of exacerbations, especially in situations of CBI [7,8].
However, it is important to emphasize that the steps proposed above are no more than recommendations by some experts, with a low degree of scientific evidence (except when bronchiectasis coexists, where the amount of evidence is greater). Similarly, there is no evidence as regards the optimal treatment. There have been no specific studies in patients with COPD and bronchial PA infection on the effect of inhaled antibiotics or macrolides (as immunomodulators), although it is true that macrolides have been shown to significantly reduce the number of exacerbations in patients with both bronchiectasis [22] and COPD (without differentiating whether or not CBI infection existed) [23]. Treatment with inhaled antipseudomonic antibiotics would be another option [24], although this remains more controversial due to the lack of studies in COPD to date. Finally, special mention should be made of treatment with inhaled corticosteroids (ICS) in these patients; although their strong anti-inflammatory effect is known, as is their immunosuppressive effect, which could produce a deleterious impact on patients with PA infection. Once again, the scientific evidence is scarce, so some authors have recommended offering ICS to patients with COPD with multiple exacerbations and peripheral eosinophilia only at the lowest possible effective dose, precisely to avoid these potential deleterious effects [25].
In short, although the isolation of PA (and other PPM) is often found in patients with COPD and has given rise to controversy, the existing evidence in this regard is very scarce, and so this editorial only seeks to reflect the personal opinion of its authors (shared by other experts) on the management of this situation. Further studies are needed, however, especially on the technical development, analysis and clinical applicability of the changes in the lung microbiome profile (dysbiosis) instead of the classical microbiological techniques of pathogenic microorganisms isolations from respiratory samples [26,27], as well as clinical trials that would definitively demonstrate the effect of existing treatments and other promising ones, such as neutrophil elastase inhibitors [28,29], or the use of big data analysis [30,31] to better assess the impact of single or repeated isolations of PA in COPD patients.

Conflicts of Interest:
The authors declare no conflict of interest.