Introduction

  • 5 decision problems: t(12;21)/ETV6-RUNX1, t(v;11q23)/KMT2A, hyperdiploidy, no aberration (examples without any aberration), t(12;21)/ETV6-RUNX1 vs. hyperdiploidy

  • 17 attributes: CD34, CD45, CD66c, CD10, CD38, CD20, CyIgM, CD33, TdT, CD13, CD22, CD24, CD9, CD15+CD65, CD123, CD81, NG2

  • number of observations in the original data set: 818

  • number of observations after removing rows with 100% missing in X: 695

  • number of observations after removing rows with 100% missing in Y: 670

  • number of observations after removing rows with more than 50% missing values in X and 0/NA in Y: 606

Descriptive statistics

Counts

decision problem 0 1 NA
t(12;21)/ETV6-RUNX1 422 52 132
t(v;11q23)/KMT2A 588 17 1
hyperdiploidy 378 124 104
no aberration (examples without any aberration) 190 257 159
t(12;21)/ETV6-RUNX1 vs. hyperdiploidy 121 52 433

Missing data

X variables

Y variables

Predictive analysis

Utilize Recursive Partitioning and Regression Trees from rpart package and methods (especially Gradient Boosting Machine) from h2o package in 10 x 5CV mode.

In model selection we have used:

  • GLM - Generalized Linear Model,
  • DRF - Distributed Random Forest,
  • GBM - Gradient Boosting Machine,
  • AML - Auto Machine Learning - Stacked Ensemble models,

with different strategies of hyperparameters optimization:

  • default - default hyperparameters,
  • best-tuning - optimization on full dataset,
  • fold-tuning - optimization on each CV fold.

Model selection - train

Model selection was conducted based on AUC measure.

t(12;21)/ETV6-RUNX1

algorithm mean sd min max
GBM_default 0.9998850 0.0001175 0.9996946 1.0000000
GBM_fold_tuning 0.9806674 0.0257683 0.9251492 1.0000000
GBM_best_tuning 0.9153129 0.0095509 0.8976127 0.9274916
GLM_default 0.9090318 0.0121553 0.8942183 0.9370389
AML_default 0.8639371 0.1157939 0.6639242 1.0000000
DRF_default 0.7327323 0.0266094 0.6736740 0.7596203
DRF_best_tuning 0.6784206 0.0263560 0.6396281 0.7133570
DRF_fold_tuning NaN NA NaN NaN

t(v;11q23)/KMT2A

algorithm mean sd min max
GBM_default 1.0000000 0.0000000 1.0000000 1.0000000
GLM_default 0.9998276 0.0005452 0.9982759 1.0000000
GBM_best_tuning 0.9996222 0.0003067 0.9988623 1.0000000
GBM_fold_tuning 0.9982977 0.0026919 0.9924475 1.0000000
AML_default 0.9613082 0.0491434 0.8906047 1.0000000
DRF_default 0.8649069 0.0465267 0.7844407 0.9211604
DRF_best_tuning NaN NA NaN NaN
DRF_fold_tuning NaN NA NaN NaN

hyperdiploidy

algorithm mean sd min max
GBM_default 0.9975811 0.0009971 0.9958310 0.9991378
GBM_best_tuning 0.9909131 0.0017519 0.9874693 0.9935398
GBM_fold_tuning 0.9446475 0.0470378 0.8562849 0.9999882
AML_default 0.8907420 0.0851610 0.8005437 1.0000000
GLM_default 0.8228283 0.0153270 0.8060114 0.8507614
DRF_best_tuning 0.7910353 0.0136755 0.7691859 0.8063778
DRF_default 0.7699460 0.0122580 0.7481930 0.7845465
DRF_fold_tuning NaN NA NaN NaN

Model selection - test

Model selection was conducted based on AUC measure.

t(12;21)/ETV6-RUNX1

algorithm mean sd min max
GLM_default 0.8837449 0.1035621 0.6862745 1.0000000
GBM_fold_tuning 0.8785816 0.0843375 0.7260870 0.9826087
DRF_fold_tuning 0.8753623 0.0960450 0.6565217 0.9826087
GBM_best_tuning 0.7946099 0.1220147 0.5391304 0.9130435
GBM_default 0.7812797 0.1205425 0.6130435 0.9217391
DRF_best_tuning 0.7804780 0.1356822 0.5695652 0.9478261
DRF_default 0.7695436 0.1322566 0.5869565 0.9347826
AML_default 0.7164570 0.1473597 0.4652174 0.9130435

t(v;11q23)/KMT2A

algorithm mean sd min max
DRF_fold_tuning 0.9471970 0.1327415 0.5719697 1
GBM_fold_tuning 0.9243939 0.1176841 0.6439394 1
DRF_default 0.8877098 0.2312182 0.2462121 1
GBM_default 0.8393124 0.1905149 0.4621212 1
DRF_best_tuning 0.8103963 0.3004466 0.2424242 1
AML_default 0.8029254 0.1935169 0.4538462 1
GBM_best_tuning 0.7700466 0.3098041 0.0615385 1
GLM_default 0.3857143 0.4996597 0.0000000 1

hyperdiploidy

algorithm mean sd min max
GBM_fold_tuning 0.8458791 0.0731504 0.7179487 0.9194139
DRF_fold_tuning 0.8446276 0.0634158 0.7321429 0.9230769
DRF_best_tuning 0.7963217 0.0706159 0.6865079 0.8974359
GBM_best_tuning 0.7925061 0.0744698 0.6488095 0.8681319
GBM_default 0.7904304 0.0753719 0.6263736 0.8690476
DRF_default 0.7855998 0.0525794 0.7216117 0.8720238
GLM_default 0.7728035 0.1177852 0.5933333 0.9523810
AML_default 0.7630800 0.0980562 0.6011905 0.8901099

Prediction RPART

t(12;21)/ETV6-RUNX1

          Reference
Prediction     0     1
         0 405.9  45.8
         1  16.1   6.2
stat mean sd min max
Accuracy 0.8694 0.0058 0.8629 0.8797
Balanced Accuracy 0.5405 0.0201 0.5111 0.5700
F1 0.1653 0.0524 0.0857 0.2400
Neg Pred Value 0.8986 0.0042 0.8925 0.9047
Pos Pred Value 0.2733 0.0713 0.1667 0.3913
Precision 0.2733 0.0713 0.1667 0.3913
Sensitivity 0.1192 0.0413 0.0577 0.1731
Specificity 0.9618 0.0057 0.9526 0.9692

t(v;11q23)/KMT2A

          Reference
Prediction   0   1
         0 585   8
         1   3   9
stat mean sd min max
Accuracy 0.9818 0 0.9818 0.9818
Balanced Accuracy 0.7622 0 0.7622 0.7622
F1 0.6207 0 0.6207 0.6207
Neg Pred Value 0.9865 0 0.9865 0.9865
Pos Pred Value 0.7500 0 0.7500 0.7500
Precision 0.7500 0 0.7500 0.7500
Sensitivity 0.5294 0 0.5294 0.5294
Specificity 0.9949 0 0.9949 0.9949

hyperdiploidy

          Reference
Prediction     0     1
         0 334.1  76.2
         1  43.9  47.8
stat mean sd min max
Accuracy 0.7608 0.0126 0.7410 0.7869
Balanced Accuracy 0.6347 0.0177 0.6057 0.6715
F1 0.4427 0.0319 0.3883 0.5069
Neg Pred Value 0.8144 0.0086 0.8000 0.8313
Pos Pred Value 0.5223 0.0348 0.4694 0.5914
Precision 0.5223 0.0348 0.4694 0.5914
Sensitivity 0.3855 0.0374 0.3226 0.4435
Specificity 0.8839 0.0164 0.8598 0.9074

no aberration (examples without any aberration)

          Reference
Prediction     0     1
         0  95.2  75.5
         1  94.8 181.5
stat mean sd min max
Accuracy 0.6190 0.0146 0.5951 0.6376
Balanced Accuracy 0.6036 0.0142 0.5779 0.6196
F1 0.6805 0.0159 0.6526 0.7011
Neg Pred Value 0.5583 0.0208 0.5246 0.5864
Pos Pred Value 0.6570 0.0116 0.6357 0.6718
Precision 0.6570 0.0116 0.6357 0.6718
Sensitivity 0.7062 0.0291 0.6615 0.7549
Specificity 0.5011 0.0295 0.4474 0.5526

t(12;21)/ETV6-RUNX1 vs. hyperdiploidy

          Reference
Prediction     0     1
         0 106.3  26.0
         1  14.7  26.0
stat mean sd min max
Accuracy 0.7647 0.0244 0.7283 0.7919
Balanced Accuracy 0.6893 0.0330 0.6358 0.7333
F1 0.5593 0.0527 0.4719 0.6275
Neg Pred Value 0.8041 0.0212 0.7721 0.8374
Pos Pred Value 0.6432 0.0658 0.5641 0.7586
Precision 0.6432 0.0658 0.5641 0.7586
Sensitivity 0.5000 0.0708 0.4038 0.6154
Specificity 0.8785 0.0317 0.8430 0.9421

Prediction GBM

t(12;21)/ETV6-RUNX1

          Reference
Prediction     0     1
         0 373.2  16.6
         1  48.8  35.4
stat mean sd min max
Accuracy 0.8620 0.0229 0.8186 0.8924
Balanced Accuracy 0.7826 0.0176 0.7423 0.8038
F1 0.5219 0.0287 0.4819 0.5714
Neg Pred Value 0.9576 0.0062 0.9457 0.9667
Pos Pred Value 0.4278 0.0473 0.3509 0.5075
Precision 0.4278 0.0473 0.3509 0.5075
Sensitivity 0.6808 0.0575 0.5769 0.7692
Specificity 0.8844 0.0314 0.8246 0.9218

t(v;11q23)/KMT2A

          Reference
Prediction     0     1
         0 581.4   6.9
         1   6.6  10.1
stat mean sd min max
Accuracy 0.9777 0.0102 0.9504 0.9851
Balanced Accuracy 0.7914 0.0362 0.7336 0.8487
F1 0.6110 0.0845 0.4231 0.7059
Neg Pred Value 0.9883 0.0021 0.9849 0.9915
Pos Pred Value 0.6599 0.1544 0.3143 0.8333
Precision 0.6599 0.1544 0.3143 0.8333
Sensitivity 0.5941 0.0757 0.4706 0.7059
Specificity 0.9888 0.0111 0.9592 0.9966

hyperdiploidy

          Reference
Prediction     0     1
         0 307.5  26.7
         1  70.5  97.3
stat mean sd min max
Accuracy 0.8064 0.0097 0.7829 0.8167
Balanced Accuracy 0.7991 0.0123 0.7770 0.8135
F1 0.6668 0.0121 0.6431 0.6777
Neg Pred Value 0.9205 0.0123 0.9008 0.9353
Pos Pred Value 0.5810 0.0184 0.5389 0.6013
Precision 0.5810 0.0184 0.5389 0.6013
Sensitivity 0.7847 0.0410 0.7177 0.8387
Specificity 0.8135 0.0225 0.7646 0.8413

no aberration (examples without any aberration)

          Reference
Prediction     0     1
         0  78.7  19.1
         1 111.3 237.9
stat mean sd min max
Accuracy 0.7083 0.0118 0.6801 0.7248
Balanced Accuracy 0.6699 0.0164 0.6305 0.6914
F1 0.7850 0.0047 0.7755 0.7926
Neg Pred Value 0.8071 0.0215 0.7692 0.8507
Pos Pred Value 0.6817 0.0137 0.6500 0.6994
Precision 0.6817 0.0137 0.6500 0.6994
Sensitivity 0.9257 0.0171 0.8949 0.9611
Specificity 0.4142 0.0482 0.3000 0.4737

t(12;21)/ETV6-RUNX1 vs. hyperdiploidy

          Reference
Prediction     0     1
         0 110.8   9.7
         1  10.2  42.3
stat mean sd min max
Accuracy 0.8850 0.0160 0.8555 0.9017
Balanced Accuracy 0.8646 0.0092 0.8528 0.8789
F1 0.8102 0.0143 0.7788 0.8283
Neg Pred Value 0.9206 0.0187 0.8992 0.9619
Pos Pred Value 0.8147 0.0677 0.7059 0.9070
Precision 0.8147 0.0677 0.7059 0.9070
Sensitivity 0.8135 0.0529 0.7500 0.9231
Specificity 0.9157 0.0432 0.8347 0.9669

Variable importance

Average rank based on training folds in 5 cross validation (repeated 10 times) based on tree split

t(12;21)/ETV6-RUNX1

t(v;11q23)/KMT2A

hyperdiploidy

no aberration (examples without any aberration)

t(12;21)/ETV6-RUNX1 vs. hyperdiploidy

Descriptive analysis

RPART decision trees

t(12;21)/ETV6-RUNX1

Confusion Matrix and Statistics

          Reference
Prediction   0   1
         0 420  14
         1   2  38
                                          
               Accuracy : 0.9662          
                 95% CI : (0.9458, 0.9806)
    No Information Rate : 0.8903          
    P-Value [Acc > NIR] : 1.125e-09       
                                          
                  Kappa : 0.8077          
                                          
 Mcnemar's Test P-Value : 0.00596         
                                          
            Sensitivity : 0.73077         
            Specificity : 0.99526         
         Pos Pred Value : 0.95000         
         Neg Pred Value : 0.96774         
              Precision : 0.95000         
                 Recall : 0.73077         
                     F1 : 0.82609         
             Prevalence : 0.10970         
         Detection Rate : 0.08017         
   Detection Prevalence : 0.08439         
      Balanced Accuracy : 0.86301         
                                          
       'Positive' Class : 1
Variable importance
CD10 25.1423989
CD24 21.9549454
CD34 11.3961721
CD38 10.1428889
CD45 8.7825103
TdT 7.4577273
CyIgM 6.7315470
CD66c 6.6255950
CD13 5.2358929
CD33 4.7591406
CD81 3.8538350
CD22 3.4798346
CD123 1.7142857
CD20 0.1669621
CD9 0.1037234
probability: primary class x x_2 x_3 x_4 x_5 x_6 x_7 x_8 x_9 x_10 x_11 x_12 x_13 x_14 x_15 x_16 x_17 x_18 x_19 x_20 x_21 x_22 x_23 x_24 x_25 x_26 x_27 x_28 x_29 x_30 x_31 x_32 x_33 x_34 x_35 x_36 x_37 x_38 x_39 x_40 x_41 x_42 x_43 x_44 x_45 x_46 x_47 x_48 x_49 x_50 x_51 x_52 x_53 x_54 x_55 x_56 x_57 x_58 x_59 x_60 x_61 x_62 x_63 x_64 cover cover_cumulative rule_no
0.04 when CD66c >= 1 & CD10 is 25 to 98 & CD45 < 4 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD22 >= 2 30% 30% 1
0.00 when CD66c >= 1 & CD10 < 25 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD9 >= 2 27% 57% 2
0.00 when CD66c < 1 & CD45 >= 2 & CD22 >= 3 6% 63% 3
0.00 when CD66c < 1 & CD10 < 16 & CD45 >= 2 & CD22 < 3 & TdT < 5 5% 68% 4
0.00 when CD66c >= 1 & CD10 < 25 & CD45 >= 2 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD9 < 2 3% 71% 5
0.00 when CD66c < 1 & CD10 < 36 & CD45 < 2 & CD24 >= 38 3% 74% 6
0.33 when CD66c < 1 & CD10 < 54 & CD45 < 2 & CD24 < 38 & CD38 < 2 & CD34 >= 4 & CD33 >= 1 3% 77% 7
0.00 when CD66c < 1 & CD10 >= 17 & CD45 >= 2 & CD22 < 2 & CD123 < 1 2% 79% 8
0.00 when CD66c >= 1 & CD10 < 98 & CD24 >= 101 & CD13 < 24 & CD38 < 20 & CyIgM < 5 1% 80% 9
0.00 when CD66c >= 1 & CD10 >= 98 & CD38 >= 2 & CD33 < 1 1% 81% 10
0.00 when CD66c >= 1 & CD10 >= 98 & CD24 >= 32 & CD38 < 2 & CD33 < 1 1% 82% 11
0.00 when CD66c < 1 & CD10 < 16 & CD45 >= 2 & CD22 < 3 & TdT >= 5 & CD81 >= 3 1% 83% 12
0.00 when CD66c < 1 & CD10 is 50 to 71 & CD45 >= 2 & CD22 is 2 to 3 1% 84% 13
0.00 when CD66c < 1 & CD10 >= 36 & CD45 < 2 & CD24 >= 58 & CD13 < 4 1% 85% 14
0.00 when CD66c < 1 & CD10 >= 64 & CD45 < 2 & CD24 < 38 & CD34 >= 4 1% 86% 15
0.00 when CD66c < 1 & CD10 < 54 & CD45 < 2 & CD24 < 38 & CD34 >= 4 & CD33 < 1 1% 87% 16
0.00 when CD66c < 1 & CD45 < 2 & CD24 is 26 to 35 & CD34 < 4 & CyIgM < 3 1% 88% 17
0.17 when CD66c >= 4 & CD10 is 25 to 98 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD22 < 2 1% 89% 18
0.33 when CD66c >= 1 & CD10 < 25 & CD45 < 2 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD9 < 2 1% 90% 19
0.67 when CD66c < 1 & CD10 < 95 & CD45 < 2 & CD24 < 26 & CD13 >= 3 & CD34 < 4 1% 91% 20
1.00 when CD66c >= 1 & CD10 >= 98 & CD24 < 32 & CD38 < 2 & CD33 < 1 1% 92% 21
1.00 when CD66c < 1 & CD10 >= 36 & CD45 < 2 & CD24 is 38 to 58 & CD13 < 4 & CyIgM < 5 & TdT < 12 1% 93% 22
1.00 when CD66c < 1 & CD10 is 54 to 64 & CD45 < 2 & CD24 < 38 & CD34 >= 4 1% 94% 23
1.00 when CD66c < 1 & CD10 < 95 & CD45 < 2 & CD24 < 26 & CD13 < 3 & CD34 < 4 1% 95% 24
1.00 when CD66c < 1 & CD45 < 2 & CD24 is 35 to 38 & CD34 < 4 1% 96% 25
0.00 when CD66c < 1 & CD10 is 16 to 50 & CD45 >= 2 & CD22 is 2 to 3 & CD81 < 3 0% 96% 26
0.00 when CD66c < 1 & CD10 >= 36 & CD45 < 2 & CD24 >= 38 & CD13 >= 4 0% 96% 27
0.00 when CD66c < 1 & CD10 >= 36 & CD45 < 2 & CD24 is 38 to 58 & CD13 < 4 & CyIgM >= 5 0% 96% 28
0.00 when CD66c < 1 & CD10 >= 36 & CD45 < 2 & CD24 is 38 to 58 & CD13 < 4 & CyIgM < 5 & TdT >= 12 0% 96% 29
0.00 when CD66c < 1 & CD10 >= 95 & CD45 < 2 & CD24 < 26 & CD34 < 4 0% 96% 30
0.50 when CD66c >= 1 & CD10 is 25 to 98 & CD45 >= 4 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD22 >= 2 0% 96% 31
0.50 when CD66c >= 1 & CD10 < 98 & CD24 >= 101 & CD13 < 24 & CD38 < 20 & CD34 < 2 & CyIgM >= 5 0% 96% 32
0.50 when CD66c < 1 & CD45 < 2 & CD24 is 26 to 35 & CD34 < 4 & CyIgM >= 3 0% 96% 33
1.00 when CD66c is 1 to 4 & CD10 is 25 to 98 & CD24 < 101 & CD13 < 24 & CD38 < 20 & CD22 < 2 0% 96% 34
1.00 when CD66c >= 1 & CD10 < 98 & CD24 >= 101 & CD13 < 24 & CD38 < 20 & CD34 >= 2 & CyIgM >= 5 0% 96% 35
1.00 when CD66c >= 1 & CD10 < 98 & CD13 < 24 & CD38 >= 20 0% 96% 36
1.00 when CD66c >= 1 & CD10 < 98 & CD13 >= 24 0% 96% 37
1.00 when CD66c >= 1 & CD10 >= 98 & CD33 >= 1 0% 96% 38
1.00 when CD66c < 1 & CD10 < 16 & CD45 >= 2 & CD22 < 3 & TdT >= 5 & CD81 < 3 0% 96% 39
1.00 when CD66c < 1 & CD10 >= 17 & CD45 >= 2 & CD22 < 2 & CD123 >= 1 0% 96% 40
1.00 when CD66c < 1 & CD10 is 16 to 17 & CD45 >= 2 & CD22 < 2 0% 96% 41
1.00 when CD66c < 1 & CD10 is 16 to 50 & CD45 >= 2 & CD22 is 2 to 3 & CD81 >= 3 0% 96% 42
1.00 when CD66c < 1 & CD10 >= 71 & CD45 >= 2 & CD22 is 2 to 3 0% 96% 43
1.00 when CD66c < 1 & CD10 < 54 & CD45 < 2 & CD24 < 38 & CD38 >= 2 & CD34 >= 4 & CD33 >= 1 0% 96% 44

t(v;11q23)/KMT2A

Confusion Matrix and Statistics

          Reference
Prediction   0   1
         0 588   5
         1   0  12
                                          
               Accuracy : 0.9917          
                 95% CI : (0.9808, 0.9973)
    No Information Rate : 0.9719          
    P-Value [Acc > NIR] : 0.0005952       
                                          
                  Kappa : 0.8235          
                                          
 Mcnemar's Test P-Value : 0.0736383       
                                          
            Sensitivity : 0.70588         
            Specificity : 1.00000         
         Pos Pred Value : 1.00000         
         Neg Pred Value : 0.99157         
              Precision : 1.00000         
                 Recall : 0.70588         
                     F1 : 0.82759         
             Prevalence : 0.02810         
         Detection Rate : 0.01983         
   Detection Prevalence : 0.01983         
      Balanced Accuracy : 0.85294         
                                          
       'Positive' Class : 1
Variable importance
NG2 12.7604797
CD24 3.0000000
CyIgM 2.7025134
CD34 2.2500000
CD123 1.9693179
CD10 1.6666667
CD45 1.5000000
CD38 0.7500000
CD20 0.2962410
CD15_CD65 0.2598018
probability: primary class x x_2 x_3 x_4 x_5 x_6 x_7 x_8 x_9 x_10 x_11 x_12 x_13 x_14 x_15 x_16 x_17 x_18 x_19 x_20 x_21 x_22 x_23 x_24 x_25 x_26 x_27 x_28 x_29 x_30 x_31 x_32 cover cover_cumulative rule_no
0.01 when NG2 is 0 & CD123 < 9 & CyIgM < 18 & CD20 < 9 & CD15_CD65 < 1 96% 96% 1
0.00 when NG2 is 0 & CD123 < 9 & CyIgM < 18 & CD20 >= 9 & CD10 >= 26 1% 97% 2
0.14 when NG2 is 0 & CD123 < 9 & CyIgM < 18 & CD20 < 9 & CD15_CD65 >= 1 1% 98% 3
1.00 when NG2 is 1 & CD24 < 5 1% 99% 4
0.00 when NG2 is 1 & CD24 >= 5 & CD34 < 16 0% 99% 5
1.00 when NG2 is 0 & CD123 < 9 & CyIgM < 18 & CD20 >= 9 & CD10 < 26 0% 99% 6
1.00 when NG2 is 0 & CD123 < 9 & CyIgM >= 18 0% 99% 7
1.00 when NG2 is 0 & CD123 >= 9 0% 99% 8
1.00 when NG2 is 1 & CD24 >= 5 & CD34 >= 16 0% 99% 9

hyperdiploidy

Confusion Matrix and Statistics

          Reference
Prediction   0   1
         0 361  17
         1  17 107
                                          
               Accuracy : 0.9323          
                 95% CI : (0.9066, 0.9526)
    No Information Rate : 0.753           
    P-Value [Acc > NIR] : <2e-16          
                                          
                  Kappa : 0.8179          
                                          
 Mcnemar's Test P-Value : 1               
                                          
            Sensitivity : 0.8629          
            Specificity : 0.9550          
         Pos Pred Value : 0.8629          
         Neg Pred Value : 0.9550          
              Precision : 0.8629          
                 Recall : 0.8629          
                     F1 : 0.8629          
             Prevalence : 0.2470          
         Detection Rate : 0.2131          
   Detection Prevalence : 0.2470          
      Balanced Accuracy : 0.9090          
                                          
       'Positive' Class : 1
Variable importance
CD123 35.622886
CD24 32.714526
CD10 25.145816
CD34 16.439912
CD9 14.285679
TdT 12.901010
CD45 10.271138
CD13 8.445808
CD22 6.269507
CyIgM 5.945709
CD38 5.340533
CD66c 5.172637
CD81 4.062801
CD20 3.455975
CD33 2.669710
probability: primary class x x_2 x_3 x_4 x_5 x_6 x_7 x_8 x_9 x_10 x_11 x_12 x_13 x_14 x_15 x_16 x_17 x_18 x_19 x_20 x_21 x_22 x_23 x_24 x_25 x_26 x_27 x_28 x_29 x_30 x_31 x_32 x_33 x_34 x_35 x_36 x_37 x_38 x_39 x_40 x_41 x_42 x_43 x_44 x_45 x_46 x_47 x_48 x_49 x_50 x_51 x_52 x_53 x_54 x_55 x_56 x_57 x_58 x_59 x_60 x_61 x_62 x_63 x_64 x_65 x_66 x_67 x_68 x_69 x_70 x_71 x_72 x_73 x_74 cover cover_cumulative rule_no
0.03 when CD123 < 1 & CD24 < 124 & CD9 < 22 & CD10 is 3 to 76 & CD13 < 16 & TdT < 14 & CD81 < 13 & CD66c >= 1 & CD45 < 4 14% 14% 1
0.15 when CD123 < 1 & CD24 < 39 & CD10 is 6 to 46 & CD13 < 16 & TdT < 9 & CD81 < 13 & CD66c < 1 12% 26% 2
0.00 when CD123 < 1 & CD24 >= 40 & CD13 < 16 & TdT < 9 & CD81 < 13 & CD66c < 1 9% 35% 3
0.00 when CD123 < 1 & CD24 < 39 & CD10 >= 47 & CD13 < 16 & TdT < 9 & CD81 < 13 & CD66c < 1 8% 43% 4
0.00 when CD123 < 1 & CD24 < 39 & CD10 < 6 & CD13 < 16 & TdT < 9 & CD81 < 13 & CD66c < 1 7% 50% 5
0.81 when CD123 >= 1 & CD24 is 15 to 61 & CD9 >= 3 & CD10 < 32 & CD38 < 6 & CD34 < 12 & CD33 < 1 & CD20 < 2 7% 57% 6
0.00 when CD123 is 1 to 2 & CD9 < 3 5% 62% 7
1.00 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 >= 8 & CD34 >= 12 & CD33 < 1 & CD20 < 2 4% 66% 8
0.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & TdT < 7 & CD38 < 5 & CD22 >= 2 & CD45 >= 2 3% 69% 9
0.08 when CD123 >= 1 & CD24 is 8 to 14 & CD9 is 3 to 13 & TdT < 7 & CD38 < 5 & CD34 >= 2 & CD22 >= 2 & CD45 < 2 3% 72% 10
0.62 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 >= 32 & CD38 < 6 & CD34 < 12 & CD33 < 1 & CD20 < 2 & CyIgM < 3 3% 75% 11
0.00 when CD123 < 1 & CD24 < 124 & CD9 < 22 & CD10 < 3 & CD13 < 16 & CD81 is 3 to 13 & CD66c >= 1 & CD22 >= 2 2% 77% 12
0.00 when CD123 >= 1 & CD24 is 61 to 126 & CD9 >= 5 2% 79% 13
0.00 when CD123 < 1 & CD24 >= 15 & CD10 >= 2 & CD13 < 16 & TdT >= 9 & CD81 < 13 & CD66c < 1 & CD22 >= 2 1% 80% 14
0.00 when CD123 < 1 & CD10 >= 80 & CD13 < 16 & CD81 < 13 & CD66c >= 1 & CD34 < 2 1% 81% 15
0.00 when CD123 < 1 & CD13 < 16 & TdT < 7 & CD81 >= 13 1% 82% 16
0.00 when CD123 >= 2 & CD9 < 3 & CD45 >= 3 1% 83% 17
0.00 when CD123 >= 2 & CD24 < 8 & CD9 >= 3 & TdT is 4 to 7 & CD38 < 5 & CD22 >= 2 & CD45 < 2 1% 84% 18
0.00 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 < 71 & CD33 >= 1 1% 85% 19
0.20 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 >= 32 & CD38 < 6 & CD34 < 12 & CD33 < 1 & CD20 < 2 & CyIgM >= 3 1% 86% 20
0.25 when CD123 < 1 & CD24 >= 15 & CD10 >= 2 & CD13 < 16 & TdT >= 9 & CD81 < 13 & CD66c < 1 & CD22 < 2 1% 87% 21
0.25 when CD123 < 1 & CD24 < 124 & CD9 < 22 & CD10 is 3 to 76 & CD13 < 16 & TdT < 14 & CD81 < 13 & CD66c >= 1 & CD45 >= 4 1% 88% 22
0.67 when CD123 < 1 & CD24 < 124 & CD9 < 22 & CD10 < 3 & CD13 < 16 & CD81 < 3 & CD66c >= 1 1% 89% 23
0.67 when CD123 < 1 & CD24 >= 124 & CD10 < 76 & CD13 < 16 & CD81 < 13 & CD66c >= 1 1% 90% 24
0.67 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 is 3 to 8 & CD34 >= 12 & CD33 < 1 & CD20 < 2 1% 91% 25
0.75 when CD123 < 1 & CD24 is 39 to 40 & CD13 < 16 & TdT < 9 & CD81 < 13 & CD66c < 1 1% 92% 26
1.00 when CD123 < 1 & CD10 >= 76 & CD13 < 16 & CD81 < 13 & CD66c >= 1 & CD34 >= 2 1% 93% 27
1.00 when CD123 < 1 & CD10 >= 14 & CD13 >= 16 1% 94% 28
1.00 when CD123 >= 2 & CD9 < 3 & CD13 < 3 & CD45 < 3 1% 95% 29
1.00 when CD123 is 1 to 2 & CD24 < 8 & CD9 >= 3 & TdT < 7 & CD38 < 5 & CD22 >= 2 & CD45 < 2 1% 96% 30
1.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & TdT >= 7 & CD38 < 5 & CD34 < 21 & CD22 is 2 to 5 & CD45 < 3 1% 97% 31
0.00 when CD123 < 1 & CD10 < 14 & CD13 >= 16 0% 97% 32
0.00 when CD123 >= 2 & CD9 < 3 & CD13 >= 3 & CD45 < 3 0% 97% 33
0.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & TdT >= 7 & CD38 < 5 & CD22 >= 5 0% 97% 34
0.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & TdT >= 7 & CD38 < 5 & CD34 >= 21 & CD22 is 2 to 5 0% 97% 35
0.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & TdT >= 7 & CD38 < 5 & CD34 < 21 & CD22 is 2 to 5 & CD45 >= 3 0% 97% 36
0.00 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD33 < 1 & CD20 >= 2 0% 97% 37
0.00 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD38 >= 6 & CD34 < 12 & CD33 < 1 & CD20 < 2 0% 97% 38
0.00 when CD123 >= 1 & CD24 is 14 to 15 & CD9 >= 3 & CD10 < 32 & CD38 < 6 & CD34 < 12 & CD33 < 1 & CD20 < 2 0% 97% 39
0.00 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 < 3 & CD34 >= 12 & CD33 < 1 & CD20 < 2 0% 97% 40
0.50 when CD123 < 1 & CD24 < 124 & CD9 < 22 & CD10 is 3 to 76 & CD13 < 16 & TdT >= 14 & CD81 < 13 & CD66c >= 1 0% 97% 41
0.50 when CD123 >= 1 & CD24 is 8 to 14 & CD9 is 3 to 13 & TdT < 7 & CD38 < 5 & CD34 < 2 & CD22 >= 2 & CD45 < 2 0% 97% 42
1.00 when CD123 < 1 & CD24 < 39 & CD10 is 46 to 47 & CD13 < 16 & TdT < 9 & CD81 < 13 & CD66c < 1 0% 97% 43
1.00 when CD123 < 1 & CD24 >= 15 & CD10 < 2 & CD13 < 16 & TdT >= 9 & CD81 < 13 & CD66c < 1 0% 97% 44
1.00 when CD123 < 1 & CD24 < 15 & CD13 < 16 & TdT >= 9 & CD81 < 13 & CD66c < 1 0% 97% 45
1.00 when CD123 < 1 & CD24 < 124 & CD9 < 22 & CD10 < 3 & CD13 < 16 & CD81 is 3 to 13 & CD66c >= 1 & CD22 < 2 0% 97% 46
1.00 when CD123 < 1 & CD24 < 124 & CD9 >= 22 & CD10 < 76 & CD13 < 16 & CD81 < 13 & CD66c >= 1 0% 97% 47
1.00 when CD123 < 1 & CD10 is 76 to 80 & CD13 < 16 & CD81 < 13 & CD66c >= 1 & CD34 < 2 0% 97% 48
1.00 when CD123 < 1 & CD13 < 16 & TdT >= 7 & CD81 >= 13 0% 97% 49
1.00 when CD123 >= 1 & CD24 is 8 to 14 & CD9 >= 13 & TdT < 7 & CD38 < 5 & CD22 >= 2 & CD45 < 2 0% 97% 50
1.00 when CD123 >= 2 & CD24 < 8 & CD9 >= 3 & TdT < 4 & CD38 < 5 & CD22 >= 2 & CD45 < 2 0% 97% 51
1.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & CD38 < 5 & CD22 < 2 0% 97% 52
1.00 when CD123 >= 1 & CD24 < 14 & CD9 >= 3 & CD38 >= 5 0% 97% 53
1.00 when CD123 >= 1 & CD24 >= 126 & CD9 >= 5 0% 97% 54
1.00 when CD123 >= 1 & CD24 >= 61 & CD9 is 3 to 5 0% 97% 55
1.00 when CD123 >= 1 & CD24 is 14 to 61 & CD9 >= 3 & CD10 >= 71 & CD33 >= 1 0% 97% 56

no aberration (examples without any aberration)

Confusion Matrix and Statistics

          Reference
Prediction   0   1
         0 169  22
         1  21 235
                                          
               Accuracy : 0.9038          
                 95% CI : (0.8726, 0.9295)
    No Information Rate : 0.5749          
    P-Value [Acc > NIR] : <2e-16          
                                          
                  Kappa : 0.8033          
                                          
 Mcnemar's Test P-Value : 1               
                                          
            Sensitivity : 0.9144          
            Specificity : 0.8895          
         Pos Pred Value : 0.9180          
         Neg Pred Value : 0.8848          
              Precision : 0.9180          
                 Recall : 0.9144          
                     F1 : 0.9162          
             Prevalence : 0.5749          
         Detection Rate : 0.5257          
   Detection Prevalence : 0.5727          
      Balanced Accuracy : 0.9019          
                                          
       'Positive' Class : 1
Variable importance
CD10 42.672515
CD24 31.537127
CD34 27.035310
TdT 24.513295
CD123 22.748730
CD66c 14.527856
CD45 12.209144
CD22 11.395381
CD81 9.367473
CD9 6.341925
CD38 6.141793
CD13 5.609190
NG2 4.523077
CD20 3.539795
CyIgM 3.491281
CD33 1.888889
probability: primary class x x_2 x_3 x_4 x_5 x_6 x_7 x_8 x_9 x_10 x_11 x_12 x_13 x_14 x_15 x_16 x_17 x_18 x_19 x_20 x_21 x_22 x_23 x_24 x_25 x_26 x_27 x_28 x_29 x_30 x_31 x_32 x_33 x_34 x_35 x_36 x_37 x_38 x_39 x_40 x_41 x_42 x_43 x_44 x_45 x_46 x_47 x_48 x_49 x_50 x_51 x_52 x_53 x_54 x_55 x_56 x_57 x_58 x_59 x_60 x_61 x_62 x_63 x_64 x_65 x_66 x_67 x_68 x_69 x_70 x_71 x_72 x_73 x_74 x_75 x_76 x_77 x_78 cover cover_cumulative rule_no
1.00 when CD123 < 1 & CD45 >= 2 & CD24 < 121 & CD10 < 121 & NG2 is 0 & CD22 >= 3 & CD81 < 12 8% 8% 1
0.00 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 32 & TdT < 14 & CD10 is 8 to 33 & CD9 is 3 to 25 & CD38 < 7 6% 14% 2
1.00 when CD123 < 1 & CD45 >= 2 & CD24 < 106 & CD66c < 20 & TdT is 4 to 8 & NG2 is 0 & CD22 < 3 & CD34 < 3 5% 19% 3
0.59 when CD123 < 1 & CD45 < 2 & CD24 >= 26 & CD66c < 1 & TdT < 6 & CD10 is 23 to 73 & NG2 is 0 & CD81 < 4 4% 23% 4
0.82 when CD123 < 1 & CD45 >= 2 & CD24 < 106 & CD66c < 20 & TdT is 4 to 9 & CD10 < 70 & NG2 is 0 & CD22 < 3 & CD34 is 3 to 11 4% 27% 5
0.36 when CD123 < 1 & CD45 < 2 & CD24 < 26 & CD66c < 1 & TdT < 6 & CD10 is 23 to 73 & NG2 is 0 & CD81 < 4 3% 30% 6
0.67 when CD123 < 1 & CD45 >= 2 & CD24 >= 38 & CD66c < 20 & TdT < 4 & NG2 is 0 & CD22 is 1 to 3 & CD34 < 11 & CD13 >= 2 3% 33% 7
1.00 when CD123 >= 1 & CD45 < 4 & CD24 < 15 & CD66c >= 2 & CD9 >= 4 & CD22 >= 3 & CD34 is 2 to 10 3% 36% 8
1.00 when CD123 is 1 to 2 & CD45 < 4 & CD24 >= 5 & CD9 < 3 & CD22 >= 2 & CD33 < 2 3% 39% 9
1.00 when CD123 < 1 & CD45 < 2 & CD24 >= 4 & TdT >= 6 & NG2 is 0 & CD22 >= 3 & CD81 < 7 3% 42% 10
1.00 when CD123 < 1 & CD45 < 2 & CD10 < 63 & NG2 is 0 & CD81 >= 7 3% 45% 11
0.00 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c >= 32 & CD10 >= 2 & CD9 >= 3 2% 47% 12
0.00 when CD123 is 1 to 2 & CD45 < 4 & CD24 is 15 to 29 & CD66c < 32 & CD10 >= 33 & CD9 >= 3 & CD13 < 3 2% 49% 13
0.00 when CD123 < 1 & CD24 < 6 & NG2 is 1 2% 51% 14
0.00 when CD123 < 1 & CD45 < 2 & TdT < 6 & CD10 >= 73 & NG2 is 0 & CD81 < 7 2% 53% 15
1.00 when CD123 >= 1 & CD45 >= 4 & TdT >= 3 2% 55% 16
1.00 when CD123 < 1 & CD45 >= 2 & CD24 < 22 & CD66c < 20 & TdT < 4 & NG2 is 0 & CD22 is 1 to 3 & CD34 < 11 & CD13 >= 2 2% 57% 17
1.00 when CD123 < 1 & CD45 >= 2 & CD66c < 20 & NG2 is 0 & CD22 < 3 & CD34 >= 12 2% 59% 18
0.00 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 32 & CD10 >= 33 & CD9 >= 3 & CD13 >= 3 1% 60% 19
0.00 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 22 & CD66c < 32 & CD10 < 8 & CD9 >= 3 1% 61% 20
0.00 when CD123 is 1 to 3 & CD45 < 4 & CD24 < 15 & CD66c < 33 & TdT >= 2 & CD9 >= 3 & CD34 >= 10 1% 62% 21
0.00 when CD123 is 1 to 3 & CD45 < 4 & CD24 < 15 & CD66c >= 33 & TdT >= 2 & CD9 >= 3 & CD22 >= 3 & CD34 >= 10 1% 63% 22
0.00 when CD123 >= 2 & CD45 < 4 & CD10 >= 8 & CD9 < 3 & CD13 < 3 1% 64% 23
0.00 when CD123 < 1 & CD45 < 2 & TdT < 6 & CD10 < 3 & NG2 is 0 & CD81 < 7 1% 65% 24
0.00 when CD123 < 1 & CD45 < 2 & TdT < 6 & CD10 is 18 to 23 & NG2 is 0 & CD81 < 7 1% 66% 25
0.00 when CD123 < 1 & CD45 < 2 & CD66c < 1 & TdT < 6 & CD10 is 23 to 73 & NG2 is 0 & CD81 is 4 to 7 1% 67% 26
0.00 when CD123 < 1 & CD45 < 2 & CD24 >= 4 & TdT >= 6 & CD10 is 19 to 43 & NG2 is 0 & CD22 < 3 & CD34 < 5 & CD81 < 7 1% 68% 27
0.00 when CD123 < 1 & CD45 >= 2 & CD66c >= 20 & NG2 is 0 & CD22 < 3 1% 69% 28
0.00 when CD123 < 1 & CD45 >= 2 & CD66c < 20 & TdT < 4 & NG2 is 0 & CD22 < 3 & CD34 < 2 & CD13 < 2 1% 70% 29
0.20 when CD123 >= 1 & CD45 < 4 & CD24 < 15 & CD9 >= 3 & CD34 < 2 1% 71% 30
0.20 when CD123 < 1 & CD45 >= 2 & CD24 is 22 to 38 & CD66c < 20 & TdT < 4 & NG2 is 0 & CD22 is 1 to 3 & CD34 < 11 & CD13 >= 2 1% 72% 31
0.25 when CD123 is 1 to 2 & CD45 < 4 & CD24 is 29 to 84 & CD66c < 32 & TdT < 9 & CD10 >= 33 & CD9 >= 3 & CD13 < 3 1% 73% 32
0.25 when CD123 >= 2 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 17 & CD10 >= 33 & CD9 >= 3 & CD34 >= 6 & CD13 < 3 1% 74% 33
0.33 when CD123 >= 1 & CD45 < 4 & CD24 < 15 & CD66c >= 2 & CD9 >= 3 & CD22 < 3 & CD34 is 2 to 10 1% 75% 34
0.33 when CD123 < 1 & CD45 < 2 & TdT < 6 & CD10 is 3 to 18 & NG2 is 0 & CD34 is 5 to 12 & CD81 < 7 1% 76% 35
0.33 when CD123 < 1 & CD45 < 2 & CD10 >= 63 & NG2 is 0 & CD81 >= 7 1% 77% 36
0.33 when CD123 < 1 & CD45 >= 2 & CD24 < 106 & CD66c < 20 & TdT >= 9 & NG2 is 0 & CD22 < 3 & CD34 < 11 1% 78% 37
0.33 when CD123 < 1 & CD45 >= 2 & CD24 < 106 & CD66c < 20 & TdT is 4 to 9 & CD10 >= 70 & NG2 is 0 & CD22 < 3 & CD34 is 3 to 11 1% 79% 38
0.33 when CD123 < 1 & CD45 >= 2 & NG2 is 0 & CD22 >= 3 & CD81 >= 12 1% 80% 39
0.67 when CD123 >= 2 & CD45 < 4 & CD24 is 15 to 84 & CD66c is 17 to 32 & CD10 >= 33 & CD9 >= 3 & CD34 >= 6 & CD13 < 3 1% 81% 40
0.67 when CD123 >= 3 & CD45 < 4 & CD24 is 22 to 84 & CD66c < 32 & CD10 < 8 & CD9 >= 3 1% 82% 41
0.67 when CD123 is 1 to 2 & CD45 < 4 & CD24 < 5 & CD9 < 3 & CD22 >= 2 & CD33 < 2 1% 83% 42
0.75 when CD123 < 1 & CD45 < 2 & CD24 >= 4 & TdT >= 6 & CD10 is 19 to 43 & NG2 is 0 & CD22 < 3 & CD34 >= 5 & CD81 < 7 1% 84% 43
0.75 when CD123 < 1 & CD45 >= 2 & CD66c < 20 & TdT < 4 & NG2 is 0 & CD22 < 3 & CD34 is 2 to 11 & CD13 < 2 1% 85% 44
0.75 when CD123 < 1 & CD45 >= 2 & CD24 >= 121 & CD10 < 121 & NG2 is 0 & CD22 >= 3 & CD81 < 12 1% 86% 45
0.80 when CD123 >= 1 & CD45 < 4 & CD24 >= 84 & CD9 >= 3 1% 87% 46
1.00 when CD123 >= 2 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 32 & CD10 >= 33 & CD9 >= 3 & CD34 < 6 & CD13 < 3 1% 88% 47
1.00 when CD123 is 1 to 3 & CD45 < 4 & CD24 is 22 to 84 & CD66c < 32 & CD10 < 8 & CD9 >= 3 1% 89% 48
1.00 when CD123 >= 2 & CD45 < 4 & CD10 < 8 & CD9 < 3 1% 90% 49
1.00 when CD123 < 1 & CD45 < 2 & CD66c >= 1 & TdT < 6 & CD10 is 23 to 73 & NG2 is 0 & CD81 < 7 & CD20 < 6 1% 91% 50
1.00 when CD123 < 1 & CD45 < 2 & TdT < 6 & CD10 is 3 to 18 & NG2 is 0 & CD34 < 5 & CD81 < 7 1% 92% 51
1.00 when CD123 < 1 & CD45 < 2 & TdT < 6 & CD10 is 3 to 18 & NG2 is 0 & CD34 >= 12 & CD81 < 7 1% 93% 52
1.00 when CD123 < 1 & CD45 < 2 & CD24 >= 4 & TdT >= 6 & CD10 < 19 & NG2 is 0 & CD22 < 3 & CD81 < 7 1% 94% 53
1.00 when CD123 < 1 & CD45 < 2 & CD24 >= 4 & TdT is 6 to 12 & CD10 >= 43 & NG2 is 0 & CD22 < 3 & CD81 < 7 1% 95% 54
0.00 when CD123 >= 1 & CD45 < 4 & CD24 < 15 & CD66c < 2 & CD9 >= 3 & CD34 is 2 to 10 0% 95% 55
0.00 when CD123 is 1 to 2 & CD45 < 4 & CD9 < 3 & CD22 < 2 0% 95% 56
0.00 when CD123 is 1 to 2 & CD45 < 4 & CD9 < 3 & CD22 >= 2 & CD33 >= 2 0% 95% 57
0.00 when CD123 >= 1 & CD45 >= 4 & TdT < 3 0% 95% 58
0.00 when CD123 < 1 & CD45 < 2 & CD24 < 4 & TdT >= 6 & NG2 is 0 & CD81 < 7 0% 95% 59
0.00 when CD123 < 1 & CD45 >= 2 & CD66c < 20 & NG2 is 0 & CD22 < 3 & CD34 is 11 to 12 0% 95% 60
0.00 when CD123 < 1 & CD45 >= 2 & CD66c < 20 & TdT < 4 & NG2 is 0 & CD22 < 1 & CD34 < 11 & CD13 >= 2 0% 95% 61
0.00 when CD123 < 1 & CD45 >= 2 & CD24 >= 106 & CD66c < 20 & TdT >= 4 & NG2 is 0 & CD22 < 3 & CD34 < 11 0% 95% 62
0.00 when CD123 < 1 & CD45 >= 2 & CD10 >= 121 & NG2 is 0 & CD22 >= 3 & CD81 < 12 0% 95% 63
0.50 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 32 & TdT < 14 & CD10 is 8 to 33 & CD9 >= 25 & CD38 < 7 0% 95% 64
0.50 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 32 & TdT < 14 & CD10 is 8 to 33 & CD9 >= 3 & CD38 >= 7 0% 95% 65
0.50 when CD123 >= 3 & CD45 < 4 & CD24 < 15 & TdT >= 2 & CD9 >= 3 & CD34 >= 10 0% 95% 66
0.50 when CD123 >= 1 & CD45 < 4 & CD24 < 15 & CD66c >= 2 & CD9 is 3 to 4 & CD22 >= 3 & CD34 is 2 to 10 0% 95% 67
0.50 when CD123 < 1 & CD45 < 2 & CD66c >= 1 & TdT < 6 & CD10 is 23 to 73 & NG2 is 0 & CD81 < 7 & CD20 >= 6 0% 95% 68
0.50 when CD123 < 1 & CD45 < 2 & CD24 >= 4 & TdT >= 12 & CD10 >= 43 & NG2 is 0 & CD22 < 3 & CD81 < 7 0% 95% 69
0.50 when CD123 < 1 & CD45 >= 2 & CD24 < 106 & CD66c < 20 & TdT is 8 to 9 & NG2 is 0 & CD22 < 3 & CD34 < 3 0% 95% 70
1.00 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c >= 32 & CD10 < 2 & CD9 >= 3 0% 95% 71
1.00 when CD123 >= 1 & CD45 < 4 & CD24 is 15 to 84 & CD66c < 32 & TdT >= 14 & CD10 is 8 to 33 & CD9 >= 3 0% 95% 72
1.00 when CD123 is 1 to 2 & CD45 < 4 & CD24 is 29 to 84 & CD66c < 32 & TdT >= 9 & CD10 >= 33 & CD9 >= 3 & CD13 < 3 0% 95% 73
1.00 when CD123 is 1 to 3 & CD45 < 4 & CD24 < 15 & CD66c >= 33 & TdT >= 2 & CD9 >= 3 & CD22 < 3 & CD34 >= 10 0% 95% 74
1.00 when CD123 >= 1 & CD45 < 4 & CD24 < 15 & TdT < 2 & CD9 >= 3 & CD34 >= 10 0% 95% 75
1.00 when CD123 >= 2 & CD45 < 4 & CD10 >= 8 & CD9 < 3 & CD13 >= 3 0% 95% 76
1.00 when CD123 < 1 & CD24 >= 6 & NG2 is 1 0% 95% 77

t(12;21)/ETV6-RUNX1 vs. hyperdiploidy

Confusion Matrix and Statistics

          Reference
Prediction   0   1
         0 119  10
         1   2  42
                                         
               Accuracy : 0.9306         
                 95% CI : (0.882, 0.9636)
    No Information Rate : 0.6994         
    P-Value [Acc > NIR] : 6.696e-14      
                                         
                  Kappa : 0.8275         
                                         
 Mcnemar's Test P-Value : 0.04331        
                                         
            Sensitivity : 0.8077         
            Specificity : 0.9835         
         Pos Pred Value : 0.9545         
         Neg Pred Value : 0.9225         
              Precision : 0.9545         
                 Recall : 0.8077         
                     F1 : 0.8750         
             Prevalence : 0.3006         
         Detection Rate : 0.2428         
   Detection Prevalence : 0.2543         
      Balanced Accuracy : 0.8956         
                                         
       'Positive' Class : 1
Variable importance
CD66c 20.357166
CD10 19.495063
CD24 9.285274
TdT 8.652694
CD123 7.567173
CD34 6.610682
CD45 5.955695
CD38 4.563971
CD81 4.367285
CD33 4.130608
CD13 3.222222
CD22 3.204678
CyIgM 2.951897
probability: primary class x x_2 x_3 x_4 x_5 x_6 x_7 x_8 x_9 x_10 x_11 x_12 x_13 x_14 x_15 x_16 x_17 x_18 x_19 x_20 x_21 x_22 x_23 x_24 x_25 x_26 x_27 x_28 x_29 x_30 x_31 x_32 x_33 x_34 x_35 x_36 x_37 x_38 x_39 x_40 x_41 x_42 x_43 x_44 x_45 x_46 cover cover_cumulative rule_no
0.03 when CD66c >= 1 & CD10 < 98 & CD24 < 36 & CD123 >= 1 & CD45 < 4 43% 43% 1
1.00 when CD66c < 1 & CD10 >= 31 & CD13 < 14 & CD38 >= 1 10% 53% 2
0.12 when CD66c >= 1 & CD10 < 98 & CD24 >= 36 & CD123 >= 1 & CD22 >= 3 9% 62% 3
0.09 when CD66c >= 1 & CD24 < 53 & CD123 < 1 & CD34 >= 2 & CD13 < 2 6% 68% 4
0.00 when CD66c < 1 & CD10 is 9 to 31 & CD24 >= 12 & CD34 >= 6 5% 73% 5
0.50 when CD66c >= 1 & CD10 < 98 & CD24 >= 36 & CD123 >= 1 & CD22 < 3 5% 78% 6
1.00 when CD66c >= 1 & CD123 < 1 & CD34 < 2 & CD81 < 5 4% 82% 7
0.25 when CD66c < 1 & CD10 < 31 & CD24 >= 12 & CD34 < 6 & TdT < 4 2% 84% 8
0.67 when CD66c >= 1 & CD24 >= 53 & CD123 < 1 & CD34 >= 2 & CD13 < 2 2% 86% 9
0.67 when CD66c < 1 & CD10 >= 31 & CD13 < 14 & CD38 < 1 2% 88% 10
1.00 when CD66c < 1 & CD10 < 31 & CD24 >= 12 & CD34 < 6 & TdT >= 4 2% 90% 11
1.00 when CD66c < 1 & CD10 < 31 & CD24 < 12 & TdT < 6 2% 92% 12
0.00 when CD66c >= 1 & CD123 < 1 & CD34 >= 2 & CD13 >= 2 & CD45 >= 2 1% 93% 13
0.00 when CD66c >= 1 & CD123 < 1 & CD34 < 2 & CD81 >= 5 1% 94% 14
0.00 when CD66c < 1 & CD10 < 31 & CD24 < 12 & TdT >= 6 1% 95% 15
0.00 when CD66c < 1 & CD10 >= 31 & CD13 >= 14 1% 96% 16
1.00 when CD66c >= 1 & CD10 < 98 & CD24 < 36 & CD123 >= 1 & CD45 >= 4 1% 97% 17
1.00 when CD66c >= 1 & CD10 >= 98 & CD123 >= 1 1% 98% 18
1.00 when CD66c >= 1 & CD123 < 1 & CD34 >= 2 & CD13 >= 2 & CD45 < 2 1% 99% 19
1.00 when CD66c < 1 & CD10 < 9 & CD24 >= 12 & CD34 >= 6 1% 100% 20