Next Article in Journal
D-Dimers Level as a Possible Marker of Extravascular Fibrinolysis in COVID-19 Patients
Previous Article in Journal
Exercise Induced Worsening of Mechanical Heterogeneity and Diastolic Impairment in Long QT Syndrome
Due to scheduled maintenance work on our core network, there may be short service disruptions on this website between 16:00 and 16:30 CEST on September 25th.
Article

Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study

1
Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 705-717, Korea
2
Medical Research Center, College of Medicine, Yeungnam University Medical Center, Daegu 705-717, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(1), 38; https://doi.org/10.3390/jcm10010038
Received: 27 October 2020 / Revised: 15 December 2020 / Accepted: 22 December 2020 / Published: 24 December 2020
(This article belongs to the Section Infectious Diseases)
Background: This study aimed to evaluate the association between sex and clinical outcomes in patients with coronavirus disease (COVID-19) using a population-based dataset. Methods: In this retrospective study, insurance claims data from the Korea database were used. Patients who tested positive for COVID-19 were included in the study. All diseases were defined according to the International Classification of Diseases 10th revision. During follow-up, the clinical outcomes, except mortality, were assessed using the electrical codes from the dataset. The clinical outcomes noted were: hospitalization, the use of inotropics, high flow nasal cannula, conventional oxygen therapy, mechanical ventilation, extracorporeal membrane oxygenation, development of acute kidney injury, cardiac arrest, myocardial infarction, acute heart failure, pulmonary embolism, and disseminated intravascular coagulation after the diagnosis of COVID-19. Results: A total of 7327 patients were included; of these, 2964 patients (40.5%) were men and 4363 patients (59.5%) were women. There were no significant differences in the Charlson comorbidity index score between men and women in the same age group. The incidence of mortality and clinical outcomes was higher among men than among women. The mortality rate was the highest for the populations aged 50–64 or ≥65 years. The subgroup analyses for age, diabetes mellitus, or hypertension showed favorable results for patient survival or clinical outcomes for women compared to men. Conclusion: Our population-based study showed that female patients with COVID-19 were associated with favorable outcomes. Furthermore, the impact of sex was more evident in patients aged 50–64 or ≥65 years. View Full-Text
Keywords: coronavirus disease; mortality; sex; clinical outcome coronavirus disease; mortality; sex; clinical outcome
Show Figures

Figure 1

MDPI and ACS Style

Cho, K.H.; Kim, S.W.; Park, J.W.; Do, J.Y.; Kang, S.H. Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study. J. Clin. Med. 2021, 10, 38. https://doi.org/10.3390/jcm10010038

AMA Style

Cho KH, Kim SW, Park JW, Do JY, Kang SH. Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study. Journal of Clinical Medicine. 2021; 10(1):38. https://doi.org/10.3390/jcm10010038

Chicago/Turabian Style

Cho, Kyu H., Sang W. Kim, Jong W. Park, Jun Y. Do, and Seok H. Kang 2021. "Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study" Journal of Clinical Medicine 10, no. 1: 38. https://doi.org/10.3390/jcm10010038

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop