- 3.4Impact Factor
- 9.9CiteScore
- 20 daysTime to First Decision
Vaccines, Volume 12, Issue 1
January 2024 - 108 articles
Cover Story: The DNA (deoxyribonucleic acid) vaccine, a gene vaccine, works by harnessing host cell machinery to produce a peptide antigen capable of generating an immune response leading to the development of durable immunity. The development requires the sequencing of a target antigen gene. The gene is synthesized and loaded into a vector, commonly either a bacterial plasmid or a viral vector. The vector system can be further engineered by adding specific molecules to enhance cellular uptake and nuclear translocation. The site and route of delivery are chosen according to targeted cell populations and immunostimulatory features. The host cell’s native machinery transcribes and translates the delivered DNA and generates an antigen product, which is then presented to immune cells. The result is a robust innate and subsequent adaptive immune response leading to the formation of immunological memory. View this paper
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Vaccines - ISSN 2076-393X