Next Article in Journal
Influenza Vaccination Strategies in Healthcare Workers: A Cohort Study (2018–2021) in an Italian University Hospital
Previous Article in Journal
A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates
Review

Is the Immunization of Pregnant Women against COVID-19 Justified?

1
Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, Italy
2
Pediatric Clinic, Pietro Barilla Children’s Hospital, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Amine A. Kamen
Vaccines 2021, 9(9), 970; https://doi.org/10.3390/vaccines9090970
Received: 16 July 2021 / Revised: 24 August 2021 / Accepted: 25 August 2021 / Published: 30 August 2021
(This article belongs to the Section COVID-19 Vaccines and Vaccination)
Maternal immunization against some infectious diseases can offer significant advantages for women, preventing maternal morbidity and mortality, or for offspring, preventing fetal disease and conferring passive immunity to neonates. Recently, clinical trials specifically to evaluate the immunogenicity, safety, and tolerability of some of the available coronavirus disease 2019 (COVID-19) vaccines in pregnant and lactating women have been planned, initiated and, in some cases, completed. This paper discusses whether the immunization of pregnant women against COVID-19 is justified and presents knowledge about the immunogenicity and safety of mRNA COVID-19 vaccines for these subjects. The results of recent studies indicate that pregnant women are at increased risk of developing severe disease compared with nonpregnant women of the same age. Studies carried out with mRNA vaccines indicate that the immunogenicity, safety and tolerability of these preventive measures in pregnant women are not different from those in nonpregnant women of the same age. Moreover, antibodies are efficiently transferred through the placenta and can be detected in breastmilk, suggesting a potential prevention of infection in the child. All these findings authorize the use of mRNA vaccines in pregnant women to protect both the mother and the child. However, further studies with larger sample size and with follow-up of the pregnant women vaccinated during different periods of pregnancy and their children are needed to better characterize the immune response of pregnant women, to define when these vaccines should be administered to obtain the best protection, and to measure vaccine efficacy against virus variants in both mothers and infants. COVID-19 vaccines based on different technological platforms cannot presently be used, and their role in pregnant women should be clarified. View Full-Text
Keywords: COVID-19; COVID-19 vaccine; maternal immunization; mother-to-child transmission; pregnancy COVID-19; COVID-19 vaccine; maternal immunization; mother-to-child transmission; pregnancy
MDPI and ACS Style

Principi, N.; Esposito, S. Is the Immunization of Pregnant Women against COVID-19 Justified? Vaccines 2021, 9, 970. https://doi.org/10.3390/vaccines9090970

AMA Style

Principi N, Esposito S. Is the Immunization of Pregnant Women against COVID-19 Justified? Vaccines. 2021; 9(9):970. https://doi.org/10.3390/vaccines9090970

Chicago/Turabian Style

Principi, Nicola, and Susanna Esposito. 2021. "Is the Immunization of Pregnant Women against COVID-19 Justified?" Vaccines 9, no. 9: 970. https://doi.org/10.3390/vaccines9090970

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop