Organisational and Structural Drivers of Childhood Immunisation in the European Region: A Systematic Review

Despite the implementation of widespread vaccination programs, the European Health Systems continue to experience care challenges attributable to organizational and structural issues. This study aimed to review the available data on aspects within the organizational and structural domains that might impact vaccination coverage. We searched a comprehensive range of databases from 1 January 2007 to 6 July 2021 for studies that reported quantitative or qualitative research on interventions to raise childhood vaccine coverage. Outcome assessments comprised organizational and structural factors that contribute to vaccine concern among pediatric parents, as well as data reported influencing the willingness to vaccinate. To analyze the risk of bias, the Ottawa, JBI’s (Joanna Briggs Institute) critical appraisal tool, and Amstar quality assessment were used accordingly. The inclusion criteria were met by 205 studies across 21 articles. The majority of the studies were conducted in the United Kingdom (6), the European Union (3), and Italy (3). A range of interventions studied in primary healthcare settings has been revealed to improve vaccination coverage rates including parental engagement and personalization, mandatory vaccination policies, program redesign, supply chain design, administering multiple/combination vaccines, improved vaccination timing and intervals, parental education and reminders, surveillance tools and Supplemental Immunisation Activity (SIA), and information model.


Introduction
The development and mass distribution of childhood vaccines has been one of the greatest public health achievements in history, underpinning marked progress in child survival and health outcomes worldwide [1]. Over the past four decades, global coverage of both longstanding and more newly available vaccines improved, and the number of zero-dose children have declined by nearly 75% since 1980 [2]. The 2011-2020 Global Vaccine Action Plan (GVAP) set forth various targets for childhood vaccination, such as reaching 90% coverage across all vaccines in National Immunisation Programmes (NIP) by 2020 [3]. However, 22.7 million children worldwide (17% of the target population) were not vaccinated with Diptheria-Tetanus-Pertussis3 (DTP3) in 2020, although this figure improved as compared to the previous year (14%) [4]. In 2016, vaccination coverage was below 95% (i.e., herd immunity-target threshold at least for most vaccines) in 22 out of immunisation clinics, missing vaccine program communication, or curtailment of vaccine services due to conflict, a natural disaster, or other disruption [25].
According to the SAGE collaboration, "recent outbreaks should be warning signs against complacency". For instance, the United Kingdom (UK) has seen a successful campaign to add pneumococcal vaccination to the primary schedule with a catch-up campaign for older children. This has resulted in a substantial reversal of previously increasing trends with falls in hospital admissions for bacterial pneumonia (20%) and empyema (22%) in 2 years after implementation, linked with uptake rates of 80% and 98% after the first and second years of the campaign, respectively [26]. To avert the worst occurrence, using appropriate surveillance tools, computerized immunisation registries collect data on individual vaccines into a nationwide database, allowing coverage monitoring and planning to maintain and enhance coverage [27].
Given the growing global concern and long lines of challenges over childhood vaccine strategies and hesitation, the current study focuses on the organizational, structural areas and encounters that must be addressed in order to maintain targeted vaccination coverage in the WHO European Region [28]. Specifically, this systematic review study aims to: (i) identify and synthesize the Organizational and Structural Institutionalized procedures, policies, and health care practices that impede or influence the success of European Nation Immunisation Programs for children aged 0-6 years. (ii) Thoroughly assess and justify the reasons for vaccine apprehension among parents and guardians of pediatric patients in private and public healthcare institutions.

Criteria for Inclusion and Exclusion
There were three basic requirements for inclusion: (1) studies published in English that reported original research, such as cohort studies, cross-sectional studies, qualitative investigations, literature reviews, ecological studies, and systematic reviews and metaanalyses; (2) children under the age of six who lived in the WHO European Area were our target group; (3) studies that reported on our primary outcome measure: the proportion of the target population who had received all of the recommended universal childhood immunisations. The results could be for single immunisations or a combination of vaccines that are due. We did not include research where the whole paper was not available or studies that did not contain any original data, such as conferences, editorials, or letters.

Search Strategy
We systematically searched electronic databases (Cochrane CENTRAL, MedLine, EM-BASE, PsycInfo, Psychology and Behavioral Sciences and CINAHL) for articles published from 1 January 2007 to 6 July 2021. We included only relevant studies published in the last 15 years. Keywords and Boolean operators were used for search strategy and tailored to each database, as reported in detail (see Table 1). keywords for identifying preventive health care using MeSH and key terms including "primary care", "primary health care", or "primary healthcare"; keyword for identifying organisational domain "organisational structure"; keywords for identifying pre-school vaccination were "child*", "childhood immunity*", 'vaccine*"; keywords for identifying the setting were "developed countries", "developing countries", "European Union", "EU", and "Europe" to identify studies reporting interventions to improve childhood immunisation coverage and to evaluate their effectiveness in children in the European region. To locate more papers, we hand-searched the reference lists from the collected studies and reviews and contacted experts in the field. However, we excluded grey literature including conference papers, dissertations, and government directives, concentrating instead on authenticated peer-reviewed literature. Table 1. Search-related keywords and Boolean operators.

Search
Search Terms 1 "vaccine hesitancy" AND ("European Union" or EU or Europe) AND (child or pediatric or paediatric or kids) 2 ("primary care" or "primary health care" or "primary healthcare") AND ("childhood immunization" or vaccine) AND ("developed countries" and "developing countries") 3 ("vaccine hesitancy" or "vaccine refusal") AND ("European Union" or EU or Europe) OR organizational structure in healthcare AND (child or kids or pediatric) 4 "vaccination coverage" AND ("European Union" or EU or Europe) AND (child or pediatric or paediatric) AND (immune and vaccine) Search terms: vaccination coverage, vaccine hesitancy, European Union, Europe, child, pediatric, kids, primary health care, childhood immunization and vaccination, developed and developing countries, organisational structure in healthcare.
The PRISMA diagram ( Figure 1) shows the selection process and the grounds for exclusion. Initially, the titles and abstracts of all publications found through a search were screened by a single investigator. All studies that did not pertain to organizational and structural domains impacting children's immunization coverage were omitted based on their titles and abstracts. Full-text articles that qualified were acquired. The relevance of these full-text articles to the relationship between organizational and structural constructs and vaccine coverage was verified after appraisal.

2
("primary care" or "primary health care" o healthcare") AND ("childhood immuni?ation AND ("developed countries" and "developin 3 ("vaccine hesitancy" or "vaccine refusal") A pean Union" or EU or Europe) OR organizati in healthcare AND (child or kids or ped 4 "vaccination coverage" AND ("European Un Europe) AND (child or pediatric or paediatri mune and vaccine) Search terms: vaccination coverage, vaccine hesitancy, European Union, Europe, c kids, primary health care, childhood immunization and vaccination, developed a countries, organisational structure in healthcare.
The PRISMA diagram ( Figure 1) shows the selection process and the exclusion. Initially, the titles and abstracts of all publications found through screened by a single investigator. All studies that did not pertain to organ structural domains impacting children's immunization coverage were omi their titles and abstracts. Full-text articles that qualified were acquired. Th these full-text articles to the relationship between organizational and structu and vaccine coverage was verified after appraisal.   This systematic review was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [29]. The electronic searches yielded a total of 3661 studies, of which 1635 and 1821 studies were eliminated after analyzing their titles and abstracts, respectively. For a full-text review, the remaining 205 publications were retrieved. There were a total of 21 papers that matched the requirements for inclusion ( Figure 1). Geographic location, age group, or outcomes of interest, as well as inadequate study design, were the most common grounds for exclusion.

Data Extraction and Quality Assessment
A single reviewer independently checked all citation titles and abstracts for eligibility, using Rayyan Artificial Intelligence [30] to find those that met the inclusion requirements. All duplicates were removed, and if the abstract did not provide enough information to determine eligibility, the entire paper was retrieved for further assessment. Skepticism about the articles was resolved by discussion with the involvement of another reviewer.
Additionally, a lone reviewer independently extracted data from included studies on study setting, participant characteristics, healthcare setting, interventions, and outcomes measured. Included studies were scored for methodological quality using Ottawa [31], JBI's critical appraisal tool [32], and Amstar [33], appropriately depending on the study design.
Responses from the focus groups (and some providers) indicated that the participants' perceptions of the celebration cards were more of a reminder than a 'call to action'.  Assessing the potential consequences of changes on mandated vaccination coverage extension of recommended vaccines thru data collection:

Study Characteristics of Mandatory Immunisation Policy
(1) Child health certificates mandatorily filled at 24 months (2) Virtually, 100% of reimbursements of vaccines delivered in a given month are available two months later in the database

•
The increase in MMR first dose and MenC second dose vaccination coverage between 2017 and 2018 was 3.0% and 5.7%, respectively. This compared with a 0.3% and 3.6% increase between 2016 and 2017 respectively.  (1) Describing and obtaining each set of VPDs a quantified relationship between the effective coverage against that disease and the residual burden of disease. (2) Defining the usage of these relationships to quantify the residual burden of disease associated with 4 distinct vaccine schedules relevant to the UK routine childhood vaccination programme.
(1) Four Immunisational schedules were explored differ by at most 19% in terms of the residual burden of disease expressed in QALYs loss. (2) The differences between the estimates of residual burden of disease associated with schedules A and B (9%) illustrate the potential benefits of scheduling vaccination to be completed at younger ages, with benefits driven by two effects within the model-younger vaccination being associated with slightly higher uptake and younger vaccination giving higher time-averaged protection among the study cohort.
Calculating effective vaccine coverage using an area under the curve approach.
(1) Taking into account the timing and timeliness of measles immunisation, children in our cohort spent on average 266 days (95% CI: 265.1-266.8) unvaccinated and susceptible to measles until their second birthday.
Of the susceptible days, 66.5% were spent susceptible due to the policy of recommending MCV1 for 12-month-olds and despite early uptake of MCV1 between 9 and 12 months by ∼20% in our cohort.
The results hold when hesitancy scores were calculated using MRP (DTP3: 95% CI -6.714, -0.074; MCV1: 95% CI -9.528, -1.169; MCV2: 95% CI -10.832, -0.282). (1) All regional coordinators for infectious diseases and vaccinations were contacted and asked to fill in a standarised online questionnaire. (2) It included 20 questions about thenumber of computerised LHU (Local Health Unit)s, use of different or the same software in the LHUs that were computerised, the name and basic characteristics of the software used. (3) Regional coordinators who reported having a single computerised regional register were asked by email or telephone about the characteristics of thesoftware used in the register, confidentiality issues, perspectives for future development and any aspects to be improved.
(1) 15 of the regions and 130 (83%) of LHUs are fully computerised, five regions are partially computerized and one does not use a computerised register.
Among the 15 fully computerised regions, eight use the same software in all LHUs, while the remaining seven use different software. In the five regions not fully computerised, the proportion of LHUs that are computerised ranges from 25% to 92% of the LHUs.
Eight of the 21 regions receive data every six months from the LHUs, four receive data in real time, three receive them quarterly and five yearly.
The capacity of the different systems to manage vaccination coverage data at regional level is very heterogeneous: of the 15 regions that are fully computerised, only six are able to calculate vaccine coverage automatically. (1) The steps needed to promote immunisation holistic, child-centric, preventive child health services, in an efficient and sensitive manner using e-health support appropriately and innovatively.
The issues identified from the situation review need cross-sectoral and cross-stakeholder consideration so as to promote informed and effective approaches to strengthening child.

Parents' Engagement and Personalisation Intervention
Only one paper on parents' engagement (celebration card-based intervention) and one study on personalization involvement (population-level interventions) that examined parental reminders and motivation were included. Using the JBI Qualitative Study Quality Scoring, the first study received a quality score of 9 out of a possible 10. Celebration card is a program aimed at informing parents about impending vaccines and encouraging parents of children who are late. Furthermore, the Celebrate and Protect program is a collaborative effort that engages parents and caregivers to build relationships with service providers and, as a result, increase immunisation uptake. Researchers should continue to experiment with strategies that focus on engaging parents with thoughtfully presented, evidence-based information, as parents' engagement and intervention strongly suggest personalisation. The second study found that when standardized population-level interventions were compared to individualized health or welfare interventions, frontline workers should be equipped with the skills and resources necessary to increase parents' compliance during direct-delivery contacts that scored a perfect ten on the JBI scale. Successful interventions will be those that foster trust, alleviate parents' concerns about unfounded vaccine risks, and assist parents in understanding that vaccinating on schedule is in the best interests of everyone, including their own children [55].

Mandatory Immunisation Policy
In the systematic review, using appropriate quality assessment tools, we looked at five studies about Mandatory Immunisation Policy (MIP)-three of them were high-quality studies, one was middle-quality, and one was low-quality. Higher vaccination coverage was linked to mandatory vaccination and the severity of the penalty. Furthermore, mandatory vaccination without nonmedical exemptions was linked to a reduced incidence of vaccine-preventable diseases in countries with mandatory immunisation. According to a study among high-income countries, current vaccination policies are not sufficient to achieve and maintain measles elimination in most countries. Strategies targeting unvaccinated children before they enter primary school can remarkably enhance the fulfillment of WHO targets [56]. In July 2017, France announced significant revisions to its vaccination policies, with children being required to be vaccinated beginning in 2018 [38]. Only three immunisations are mandated at this time: diphtheria, tetanus, and polio. All 11 childhood immunisations presently recommended by health authorities will be made mandatory under new legislation [57]. This legislation follows Italy's announcement in May 2017 that all children aged 4-16 years would be obliged to get 12 recommended immunisations, including for the hepatitis B virus, in order to attend school, with substantial fines for non-compliance [58].

Vaccination Program Remodeling
The two Vaccination Program Remodeling studies included in the systematic review attained an Ottawa Quality Assessment for Study score of 8 out of 10, resulting in an expansion of the present vaccination schedule to include Hepatitis B and/or Men B, maximizing a general practitioner (GP) appointment with the amount of desired injectable vaccinations; reducing a future immunisation-dose-visit and limiting any foreseeable missed vaccinations [41]. Another included UK-related study, demonstrating the feasibility and utility of the Vaccination Remodeling approach, found that the four investigated schedules differed by at most 19% in terms of residual disease burden expressed in quality-adjusted life year (QALY) loss; it was realized that the largest residual of disease is related with measles and pneumococcal infection, according to each schedule [44].

Vaccination Procurement and Distribution
The three included studies on procurement and distribution received an 8 out of 10, with one included study of increased use and procurement of serotype vaccine demonstrating a significant reduction in Invasive Pneumococcal Disease (IPD) in the Czech Republic [43], through the Ottawa Quality Appraisal scale for a cohort study. In addition, having the same quality scoring, an included study in England and Wales found a lower immunisation probability among larger families with eligible children [42]. Additionally, according to a study conducted in the United Kingdom, if immunisation can begin without significant delays, strategies based on responsive vaccine purchase offer a greater advantage than plans based on the procurement and maintenance of a stockpile [44]. IPD incidence in children is being reduced further through universal administration and distribution using broader serotype coverage rather than non-vaccine serotypes, as well as increased vaccination rates [59].

Combination/Multiple Vaccine Administration
One study included in the review discussing administering multiple/combination vaccines received an 8 out of 10 using Ottawa quality scaling. The recommended minimum interval between DTaP-IPV-Hib-2 and DTaP-IPV-Hib-3 was generally followed by vaccination providers [45]. However, another finding indicates that the reluctance to administer more than three injections in a single GP visit during infancy could be a problem [53]. Evidently, providing DTaP-IPV-Hib-3 and MMR-1 at the same time resulted in low Danish Nationwide Register compliance [45].

Improved Immunisation Timing and Intervals
Two included studies scored high on immunisation timing and intervals from the Vaccination Programs in the systematic review. One study quality score was 9 out of a possible 10 using the Ottawa Scale for Cohort Study. This outcome implies that the said effectiveness evolved in both countries (Armenia and Kyrgyzstan), resulting in a significant increase in immunisation coverage over the last few decades [47]. In reality, the proportion of children in Armenia with a correctly timed three-dose vaccination of DPT increased from 75% (1997) to 87% (2012) and the proportion of children in Armenia with a correctly timed first dose of DPT-increased from 46% (2000) to 66% (2010) [47]. On the contrary, in a group of children aged 6 months to 2 years who were reflecting the age distribution in the cohort study, effective vaccine coverage of measles was lower [46].

Parental Education and Reminder
Two of the evaluations looked at the efficacy of basic parental education programs in terms of vaccination. One study examined immunisation coverage and discovered that a child's age was a significant predictor of vaccination completion, while another examined new immunisation information and verbal explanations and discovered that they received a 9 out of 10 quality rating and an 8 out of 10 quality rating, respectively. Both of these studies exhibited a significant influence on vaccination rates and coverage, underlining the need for creating an efficient vaccine reminder system, particularly for newly released vaccinations [48,49]. This review looked at educational programs that may be given legally in the setting of primary care. However, giving information or education to allow parents or guardians, as well as communities, to make educated health decisions is a crucial component of all health systems [60].

Surveillance Tools and Supplementary Immunisation Activity (SIA)
Two included studies were about surveillance tools and SIA, one of which was conducted in the UK and Northern Ireland and received an 8 out of 10 on the Ottawa Appraisal tool for Cohort study. Our assessment found that two primary care data sets about surveillance tools were insufficient for reliably assessing vaccination coverage and revealed that the triangulation routine data revealed little additional immunisation activity. For instance, when a 25% coverage underestimation adjustment factor was used in the sensitivity analysis rather than 50%, susceptibility estimations indicated that no birth cohort between 1989-1990 and 2006-2007 attained a sufficiently high degree of immunity to prevent measles transmission [51]. Moreover, using a public health monitoring instrument, an included ecological study scored 10 out of 16 on the AMSTAR Quality Appraisal-averages for vaccine uptake indicated substantial heterogeneity between European area nations. For example, DPT3 uptake varies significantly by nation, ranging from 86.26 percent in Romania to 99.87 percent in Hungary [50].

Information Technology
The two studies looking at the progress in the child health information model received high marks in our quality evaluation. Limitations in technological availability and advances in service delivery and record-keeping were recognized and agreed upon in these investigations. In fact, only six of Italy's 15 completely computerized regions can determine vaccination coverage automatically [52]. Additionally, new research is increasingly demonstrating the potential benefits of novel approaches such as text messages to transform how reminder/recall is implemented [61].

Discussion and Implications
Policymakers and healthcare managers in the European Region must use sound judgment in determining the most efficient use of resources available to preserve and enhance healthcare quality in order to maintain and/or increase targeted vaccination coverage. When making such decisions, they must look at the potential areas for improvement initiatives in primary health care (PHC) activities from both structural and organizational perspectives, the plausible economic impacts of introducing new quality improvement interventions, and the expected potential benefits of any changes in healthcare worker behavior. Our systematic review study found that including parental engagement and personalization, mandatory vaccination policy, vaccine program redesign, vaccine procurement and distribution, administering multiple/combination vaccines, improved vaccination timing and intervals, parental education and reminders, and administering concurrent vaccinations could be effective in improving Expanded Program on Immunisation (EPI) performance specifically in the WHO European Region. When determining which combination of interventions to use for which community or at what time period, policymakers and decision-makers would need to determine intervention strategies that might help raise childhood vaccination rates.
Parents' engagement and personalisation interventions to promote primary vaccination uptake in children have been described in a number of studies. Parental participation through the use of celebration cards is an effective strategy. Participants' perceptions of celebration cards were more of a reminder than a "call for action", which may be perceived as a secondary reminder, according to responses from the focus group and some providers. In one intervention study, according to a comparative examination of street-level negotiation, nurses in all three nations (England, Israel, and Sweden) responded to compliance by participating in negotiations with parents, which is affected by institutional alternatives accessible to health care providers in their compliance efforts [34]. In Greece, total immunisation rates for new vaccinations (Men C, PCV7, varicella, Hepatitis A) were lower, ranging from 61% to 92%, indicating that parental reminders are needed [49]. This outcome could be due to a lack of awareness, new vaccine efforts, or a combination of factors. Interestingly, a relevant study reiterated that involving communities and relevant leaders in immunisation programs can be very effective [34] However, the lines of responsibility and the authority to determine and execute different measures need to be clarified to ensure that such measures are linked with national health policy and do not deter underserved families from vaccinating their children [62].
MIP comparative analysis on two periods (2006-2010 and 2015-2017) has shown that, for non-vaccination in children, there was an increase from a mean of 3.4% to 5.5%, after the national immunisation policy arms had been lifted in the later period [37,63]. In a study collecting data from 31 European countries, the totality of participants was in favour of vaccinations in childhood, eleven nations of which introduced mandatory vaccination (35.4%), while the others strongly recommended vaccination [37]. This likely represents a strong intention among European national leaders to promote the healthy and free mobility of their citizens in the direction of enormous globalization throughout the European region. In fact, following the infant mandatory immunisation in 2018, the proportion of mothers in favour of vaccination increased significantly-Hepatitis B (Hep B) and Meningococcal C (Men C) vaccination coverage rates significantly progressed between 2017 and 2018 [38]. Similarly, vaccination coverage for the first dose of MenC has increased by 36.4 percent among infants in France during the same period, resulting in an almost threefold drop in MenC cases compared to the preceding five years. On the contrary, notable recommendations from a study include unanimous support for mandatory childhood vaccination in Ontario, the need for broad educational communication about mandatory and optional vaccination (vaccines that are not included in the immunisation program due to concerns about side effects, high costs, and a lack of information) [64], and the development of a no-fault compensation scheme for Adverse Events Following Immunisations (AEFIs) [65]. This upheaval around multi-stakeholders may arise from debatable issues and pointing fingers about taking AEFIs responsibility. Remarkably, between the 2000 and 2012 surveys in Armenia, the most significant rise in correctly timed vaccines was recorded for MCV, which increased by 59 percent from 39 percent to 62 percent. In Kyrgystan, after three years of evaluation, a similar pattern was noticed, with a 12 percent increase [47]. However, due to policy changes in Switzerland, 66.5 percent of children aged 9 to 12 months were found to be susceptible, despite a cohort study showing a 20 percent early uptake of MCV1 between 9 and 12 months [46]. These data can be used to help shape legislation aimed at raising immunisation rates.
Using Information Technology (IT), the European Commission, member states, and child health stakeholders agreed to make progress in developing child health information models and digital health standards, as well as identifying areas that require further standardization and desirable steps toward innovation in service delivery and recordkeeping [66]. Only eight of Italy's 21 regions receive data in real-time; three receive it quarterly, and five receive it annually [52]. The ability of various systems to manage vaccination coverage data at the regional level varies greatly; only six of the 15 completely computerized regions can calculate vaccine coverage automatically [67]. Only three of these six can calculate coverage using individual data from the Local Health Units (LHUs) in real-time. Relative to an increasing information technology need, research implied that commercial viability will depend on healthcare policy/public acceptability of microneedle technology [52]. An effort must be made to identify the barriers to acceptance and overcome them by increasing awareness and education in stakeholder groups pertaining to the paediatric population [68].
Increasing education among more than half of the parental group lead to an expressed desire to learn more about immunisations for their children [48]. Parents who were unsure if they were following the recommended immunisation schedule and if it was a good idea for their children, as well as parents of first-born children, were more likely to require additional information. This discovery may necessitate increased maternal education and reminders, particularly among prime mothers, as well as tailored intervention. Findings from a systematic review and meta-analysis suggested that several robust interventions, particularly postal reminders, combined recall and reminder strategies, and discussionbased education, can increase childhood immunisation coverage [69]. Indeed, research highlights the challenges parents encounter when choosing whether or not to vaccinate their children [48].
In administering multiple/combination vaccines, contributing variables according to the Danish study included in this systematic review could be vaccination providers' aversion to giving numerous injections and a preference for sticking to the immunisation sequence in the vaccination program; more work is needed to increase vaccine timeliness and coverage [45]. Backing up the results of the present study showed that Adverse Event Following Immunisation (AEFI) was very rare; the vast majority of them were non-serious and, despite the claims of anti-vaccination movements, the simultaneous administration of vaccines was safe and did not influence the risk of reporting a serious AEFI, particularly in children [70]. Additionally, according to the study findings, fully using all possibilities for simultaneous delivery of all age-eligible vaccine doses during the same immunisation visit is crucial for meeting the 95 percent MCV2 coverage objective. Future treatments concentrating on the group with risk factors identified could significantly reduce missed opportunities (MO) for simultaneous MCV2 injection, to enhance MCV vaccination coverage, and ultimately meet the objective of eliminating measles [71]. Interventions with parents of partly vaccinated children should prioritize reducing obstacles to reaching community health professionals in order to achieve a schedule completion on a directed basis [72]. Indeed, vaccination data on long-term immune response durability, immunological memory, and vaccine efficiency are highly anticipated in a timely manner, as is recombination [73].
Regarding vaccine procurement and delivery, if immunisation can begin without significant delays, plans based on a responsive vaccine purchase have a greater benefit than plans based on the purchase and maintenance of a stockpile [44]. Ironically, this is not predicated on a responsively bought vaccination being more effective than a stockpiled vaccine, but rather on avoiding the expense of maintaining and refilling a reserve. Meanwhile, according to a study conducted in England and Wales, children living in areas of higher disadvantage and in larger families are less likely to obtain the influenza vaccine [42]. Finding out whether techniques like providing vaccines in diverse locations may increase vaccination uptake among children, particularly in underprivileged populations, is critical. Furthermore, research done in the Czech Republic found that a higher vaccination rate and a single, more comprehensive vaccine for regular childhood immunisation may reduce IPD in children [43]. While the structure and operations of immunisation programs differ between countries, relevant authorities should do more research to identify areas that may need redesigning to make the vaccine supply chain system more efficient and effective to achieve the strategic priority goals of the immunisation agenda 2030 [74]. For instance, to enhance vaccination administration, appropriate regulations, vaccine sourcing, purchasing, logistics, and techniques should be adopted for distinct areas and regions [75].
A UK study illustrates the potential value of analyzing the program-wide effect of vaccination schedule changes, and a newer framework is a vital step toward building a technique for doing so consistently [53]. In another piece of UK research, vaccination program remodeling is potentially beneficial in evaluating the program-wide impact of adjustments to an immunisation schedule has been established and our framework is a significant step toward developing a method for doing so, systematically [41]. A structured method was proposed to derive intervention scenarios from the conceptual Immunisation System (IMS) diagram. Probably, a newly designed framework can be applied as a problem structuring tool, and as part of the system design process [76].
Using a surveillance tool and supplemental vaccination activity in areas with a higher prevalence of vaccine reluctance, a study conducted in the European Union found statistically significantly lower regional vaccination immunisation rates [50]. Eventually, for instance, researchers were able to get new insights into population immunity and identify susceptible populations by merging routine data on measles vaccination coverage with disease monitoring, which aided in prioritizing public health actions aimed at closing immunity gaps. A collaborative study also emphasized the need to integrate the requirement for district-level coverage estimates with the operational and cost consequences of surveying district-level representatives [77]. According to the WHO, it is important to develop a monitoring and evaluation (M and E) plan at the same time as the intervention is being designed, and implementation is being planned [78]. Survey tools are critical for evaluating SIA coverage, which is especially prone to inaccuracy due to the lack of time available to verify the age or residency of those arriving for vaccination or to appropriately record and report immunisations. For routine vaccination coverage, the multiple indicators cluster survey (MICS) and demographic and health survey (DHS) will usually be sufficient to monitor trends at national and often also provincial levels [79].

Strengths and Limitations
Our search strategies turned up more studies than any previous review of its kind. We combined studies from a variety of clinical settings and socioeconomic demographics in industrialized countries, allowing us to generalize the findings in this context. Many developed countries have ample practitioners who provide universal access to primary care services. To guarantee the broadest possible range of studies and to avoid publication bias, the scoping review that includes different databases published in peer-reviewed journals were searched. Hence, we excluded studies outside the WHO European Region because health systems organization might differ profoundly, translating into different barriers, including financial barriers and at a population-to-health workers level that is generally irrelevant to parents and general practitioners in many developed countries that provide universal access to primary care services. The settings, service delivery, intervention delivery, and quality of the included studies were all different, making meta-analysis challenging. Additionally, we did not include studies written in languages other than English, which is the study's fundamental flaw. Finally, since a single individual was responsible for data search, data extraction, and risk of bias assessment, human mistake or experimenter bias cannot be ruled out.

Policy Implications and Future Research
The impact of general practitioner financial incentives and healthcare workers commensurate on vaccine uptake was not investigated. These disparities are assumed to be due to inclusion criteria leaning towards our systematic review study. Vaccination interventions have a stronger impact on individuals who are most at risk of being under-vaccinated. As a result, it is critical that vaccine coverage statistics be gathered in a way that shows disparities in uptake rates within socioeconomic groups, as well as between the general public and healthcare providers. In creating a bigger picture, these studies indicate the potential benefits of evaluating the program-wide impact of immunisation schedule modifications, and framework modifications can undoubtedly help improve vaccination programs and coverage over time. There is a need for further research to investigate alternatives to traditional policy reform. We may need to redesign and rebuild from the ground up [80].

Conclusions
Maintaining high vaccine uptake rates is critical to the success of any vaccination program and the improvement of children's health. Parents and the general public must be actively engaged by health planners and specialists, and process mechanisms must be implemented to guarantee that children receive primary prevention. A number of measures have been identified in our systematic review study that can help boost childhood immunisation rates in the WHO European region. These include Parents' Engagement and Personalisation Intervention, Mandatory Immunisation Policy, Vaccination Program Remodeling, Vaccination Procurement and Distribution, Administering Multiple/Combination Vaccines, Improved Immunisation Timing and Intervals, Parental Education and Reminder, Administering Multiple/Combination Vaccines, Vaccination Procurement and Distribution, Vaccination Program Remodeling, and Surveillance Tool and SIA. Hence, more research is needed to determine the effectiveness of these interventions and their effects on low vaccination rates for vaccine-preventable diseases in children.