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Antioxidants
Volume 9
Issue 9
10.3390/antiox9090823
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Article

Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

by
Chien-Chang Ho
1,2,
Po-Sheng Chang
3,4,
Hung-Wun Chen
3,
Po-Fu Lee
1,5,
Yun-Chi Chang
1,6,
Ching-Yu Tseng
1,2 and
Ping-Ting Lin
3,7,*
1
Department of Physical Education, Fu Jen Catholic University, New Taipei City 242304, Taiwan
2
Research and Development Center for Physical Education, Health, and Information Technology, College of Education, Fu Jen Catholic University, New Taipei City 242304, Taiwan
3
Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan
4
Graduate Program in Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan
5
Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei City 111396, Taiwan
6
Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei City 112304, Taiwan
7
Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402367, Taiwan
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(9), 823; https://doi.org/10.3390/antiox9090823
Received: 4 August 2020 / Revised: 1 September 2020 / Accepted: 1 September 2020 / Published: 3 September 2020
(This article belongs to the Special Issue Health Effects of Coenzyme Q10)
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Abstract

The aim of this study is to investigate the glycemic profile, oxidative stress, and antioxidant capacity in athletes after 12 weeks of ubiquinone supplementation. It was a double-blinded, randomized, parallel, placebo-controlled study. Thirty-one well-trained college athletes were randomly assigned to ubiquinone (300 mg/d, n = 17) or placebo group (n = 14). The glycemic profile [fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)], plasma and erythrocyte malondialdehyde (MDA), total antioxidant capacity (TAC), and ubiquinone status were measured. After supplementation, the plasma ubiquinone concentration was significantly increased (p < 0.05) and the level of erythrocyte MDA was significantly lower in the ubiquinone group than in the placebo group (p < 0.01). There was a significant correlation between white blood cell (WBC) ubiquinone and glycemic parameters [HbA1c, r = −0.46, p < 0.05; HOMA-IR, r = −0.67, p < 0.01; QUICKI, r = 0.67, p < 0.01]. In addition, athletes with higher WBC ubiquinone level (≥0.5 nmol/g) showed higher erythrocyte TAC and QUICKI and lower HOMA-IR. In conclusion, we demonstrated that athletes may show a better antioxidant capacity with higher ubiquinone status after 12 weeks of supplementation, which may further improve glycemic control. View Full-Text
Keywords: ubiquinone supplementation; athletes; glycaemia; antioxidant; sport nutrition ubiquinone supplementation; athletes; glycaemia; antioxidant; sport nutrition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Ho, C.-C.; Chang, P.-S.; Chen, H.-W.; Lee, P.-F.; Chang, Y.-C.; Tseng, C.-Y.; Lin, P.-T. Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial. Antioxidants 2020, 9, 823. https://doi.org/10.3390/antiox9090823

AMA Style

Ho C-C, Chang P-S, Chen H-W, Lee P-F, Chang Y-C, Tseng C-Y, Lin P-T. Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial. Antioxidants. 2020; 9(9):823. https://doi.org/10.3390/antiox9090823

Chicago/Turabian Style

Ho, Chien-Chang, Po-Sheng Chang, Hung-Wun Chen, Po-Fu Lee, Yun-Chi Chang, Ching-Yu Tseng, and Ping-Ting Lin. 2020. "Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial" Antioxidants 9, no. 9: 823. https://doi.org/10.3390/antiox9090823

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