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Open AccessArticle

Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers

1
Department of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja S/N, 18071 Granada, Spain
2
Nutrition and Food Science Doctorate Program (RD 99/2011), University of Granada, 18012 Granada, Spain
3
Functional Food and Metabolic Prevention Lab, Faculty of BioSciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
4
Andalusian School of Public Health, Instituto de Investigación Biosanitaria ibs.GRANADA, Univeristy Hospital of Granada/University of Granada, 18011 Granada, Spain
5
CIBER Epidemiología y Salud Pública, CIBERESP (Centro de Investigación Biomédica), 28029 Madrid, Spain
6
Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, 20014 Donostia-San Sebastian, Spain
7
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, and CIBER Oncology, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contribute equally to this work.
Antioxidants 2020, 9(4), 301; https://doi.org/10.3390/antiox9040301
Received: 21 March 2020 / Revised: 31 March 2020 / Accepted: 3 April 2020 / Published: 5 April 2020
(This article belongs to the Special Issue Total Antioxidant Capacity in Health and Disease)
(1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these associations in 210 participants from two Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) centers. (2) Methods: D-NEAC was estimated using published NEAC values in food. P-NEAC and total polyphenols (TP) were quantified by FRAP (ferric-reducing antioxidant power), TRAP (total radical-trapping antioxidant parameter), TEAC-ABTS (trolox equivalent antioxidant capacity-Azino Bis Thiazoline Sulfonic), ORAC (oxygen radical absorbance capacity) and Folin–Ciocalteu assays. Nutrient antioxidants (carotenes, α-tocopherol, ascorbic acid, retinol, uric acid, Q9 and Q10 coenzymes) and inflammation markers (IL-6, IL-8, CRP, TNF-α, PAI-I, resistin and adiponectin) were also analyzed. Spearman correlation and linear regression analyses were performed in association analyses. Analyses were stratified by covariates and groups were defined using cluster analysis. (3) Results: P-FRAP was correlated with D-NEAC, and significantly associated with P-NEAC in multivariate adjusted models. P-FRAP levels were also significantly associated with plasma antioxidants (log2 scale: TP β = 0.26; ascorbic acid β = 0.03; retinol β = 0.08; α-tocopherol β = 0.05; carotenes β = 0.02; Q10 β = 0.06; uric acid β = 0.25), though not with inflammation-related biomarkers. Different profiles of individuals with varying levels of P-NEAC and biomarkers were found. (4) Conclusions: P-NEAC levels were to some extent associated with D-NEAC and plasma antioxidants, yet not associated with inflammation response. View Full-Text
Keywords: total antioxidant capacity; dietary antioxidants; antioxidant status; oxidative stress; inflammatory markers total antioxidant capacity; dietary antioxidants; antioxidant status; oxidative stress; inflammatory markers
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Carrión-García, C.J.; Guerra-Hernández, E.J.; García-Villanova, B.; Serafini, M.; Sánchez, M.-J.; Amiano, P.; Molina-Montes, E. Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers. Antioxidants 2020, 9, 301.

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