Next Article in Journal
A Study of the Protective Properties of Iraqi Olive Leaves against Oxidation and Pathogenic Bacteria in Food Applications
Next Article in Special Issue
Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson’s Disease
Previous Article in Journal
The Importance of NADPH Oxidases and Redox Signaling in Angiogenesis
Previous Article in Special Issue
Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Antioxidants 2017, 6(2), 33;

The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics

Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA
Author to whom correspondence should be addressed.
Academic Editor: Yisang Yoon
Received: 4 March 2017 / Revised: 10 May 2017 / Accepted: 12 May 2017 / Published: 17 May 2017
(This article belongs to the Special Issue Mitochondrial Shape Change in Physio-Pathology)
Full-Text   |   PDF [924 KB, uploaded 17 May 2017]   |  


Mitochondria are dynamic organelles that alter their organization in response to a variety of cellular cues. Mitochondria are central in many biologic processes, such as cellular bioenergetics and apoptosis, and mitochondrial network morphology can contribute to those physiologic processes. Some of the biologic processes that are in part governed by mitochondria are also commonly deregulated in cancers. Furthermore, patient tumor samples from a variety of cancers have revealed that mitochondrial dynamics machinery may be deregulated in tumors. In this review, we will discuss how commonly mutated oncogenes and their downstream effector pathways regulate the mitochondrial dynamics machinery to promote changes in mitochondrial morphology as well as the physiologic consequences of altered mitochondrial morphology for tumorigenic growth. View Full-Text
Keywords: mitochondrial dynamics; oncogenic signaling; cancer mitochondrial dynamics; oncogenic signaling; cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Nagdas, S.; Kashatus, D.F. The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics. Antioxidants 2017, 6, 33.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top