Next Article in Journal
Early Life Stress and Pediatric Posttraumatic Stress Disorder
Next Article in Special Issue
Epileptiform Neuronal Discharges Impair Astrocyte Syncytial Isopotentiality in Acute Hippocampal Slices
Previous Article in Journal
Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease
Previous Article in Special Issue
Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes
Open AccessReview

No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience

1
Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, 3000 Leuven, Belgium
2
Laboratory of Neuronal Wiring, VIB-KU Leuven Center for Brain and Disease Research, 3000 Leuven, Belgium
3
Life & Medical Sciences (LIMES) Institute, Faculty of Mathematics and Natural Sciences, University of Bonn, 53115 Bonn, Germany
4
The Bioinformatics CRO, Niceville, FL 32578, USA
5
Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Brain Sci. 2020, 10(3), 168; https://doi.org/10.3390/brainsci10030168
Received: 13 November 2019 / Revised: 2 March 2020 / Accepted: 5 March 2020 / Published: 13 March 2020
(This article belongs to the Special Issue Understanding the Molecular Diversity of Astrocytes)
Astrocytes are ubiquitous in the central nervous system (CNS). These cells possess thousands of individual processes, which extend out into the neuropil, interacting with neurons, other glia and blood vessels. Paralleling the wide diversity of their interactions, astrocytes have been reported to play key roles in supporting CNS structure, metabolism, blood-brain-barrier formation and control of vascular blood flow, axon guidance, synapse formation and modulation of synaptic transmission. Traditionally, astrocytes have been studied as a homogenous group of cells. However, recent studies have uncovered a surprising degree of heterogeneity in their development and function, in both the healthy and diseased brain. A better understanding of astrocyte heterogeneity is urgently needed to understand normal brain function, as well as the role of astrocytes in response to injury and disease. View Full-Text
Keywords: astrocyte; heterogeneity; morphology; development; molecular profiling; physiology; function; injury and disease; injury and disease astrocyte; heterogeneity; morphology; development; molecular profiling; physiology; function; injury and disease; injury and disease
Show Figures

Figure 1

MDPI and ACS Style

Pestana, F.; Edwards-Faret, G.; Belgard, T.G.; Martirosyan, A.; Holt, M.G. No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience. Brain Sci. 2020, 10, 168.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop